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person · Reporting owner

Hadjimichael George

Disclosed activity across 1 company

Tapewire entity
159608
SEC CIK
0001674499

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Reported relationships

Latest disclosed role at each company.

No relationships currently tracked through insider filings.

Disclosed balances

About these balances

Latest available filing per company, not a reconstructed current portfolio. Matching sequences show the last reported balance with all source rows expandable; grouping alone does not establish account ownership. Do not add unresolved positions together. Filings may omit unchanged positions, and amendments may correct only part of an older disclosure. Jointly reported shares are not necessarily this owner's personal holdings.

No balances currently tracked through insider filings.

Past disclosures · reporting ended (1)

No longer tracked through insider filings. These historical balances do not imply present ownership or a zero position.

Karyopharm Therapeutics Inc.

Report date February 28, 2019 · Filed March 04, 2019

Jointly reported with Chione Ltd, Czernik Marcin, Hadjimichael Andreas, Smolokowski Wiaczeslaw

Section 16 reporting ended · disclosed 2019-03-04. Current position is not established by this disclosure.

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
COMMON STOCKSEC Table I · non-derivativeDirect6,000,000 Reported balance After 2019-02-28 transaction · row 1 Joint disclosure: continuity of the reported position is unresolved; see ownership footnotes.
1 source row

Row 1 · 2019-02-28 · Sale · Disposed 149,624 · Balance 6,000,000

F1: The price reported in Column 4 is a weighted average price. The shares were sold at prices ranging from $4.04 to $4.25, inclusive.

F2: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

Filing footnotes · ownership attribution and instrument terms

F1: The price reported in Column 4 is a weighted average price. The shares were sold at prices ranging from $4.04 to $4.25, inclusive.

F2: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

Transaction history

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateCompanyActivity / securityShares / unitsReported priceReported valueDetails
February 28, 2019 Filed Mar 4, 2019 20:28 UTC Karyopharm Therapeutics Inc. KPTI · Entity 781 SaleCOMMON STOCK 149,624 $4.14 $619,114.19
Disclosure

SEC source: 0001213900-19-003551 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,000,000

F1 · price: The price reported in Column 4 is a weighted average price. The shares were sold at prices ranging from $4.04 to $4.25, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

Read SEC document
February 27, 2019 Filed Feb 27, 2019 20:12 UTC Karyopharm Therapeutics Inc. KPTI · Entity 781 SaleCOMMON STOCK 558,243 $4.51 $2,515,833.73
Disclosure

SEC source: 0001213900-19-003242 · ownership.xml · nonDerivative · entry 3

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,149,624

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 02/25/2019 at prices ranging from $4.80 to $5.31, inclusive, on 02/26/2019 at prices ranging from $5.00 to $5.08, inclusive, and on 02/27/2019 at prices ranging from $4.40 to $4.675, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within each of the ranges set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

Read SEC document
February 26, 2019 Filed Feb 27, 2019 20:12 UTC Karyopharm Therapeutics Inc. KPTI · Entity 781 SaleCOMMON STOCK 123,400 $5.00 $617,209.78
Disclosure

SEC source: 0001213900-19-003242 · ownership.xml · nonDerivative · entry 2

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,707,867

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 02/25/2019 at prices ranging from $4.80 to $5.31, inclusive, on 02/26/2019 at prices ranging from $5.00 to $5.08, inclusive, and on 02/27/2019 at prices ranging from $4.40 to $4.675, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within each of the ranges set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

Read SEC document
February 25, 2019 Filed Feb 27, 2019 20:12 UTC Karyopharm Therapeutics Inc. KPTI · Entity 781 SaleCOMMON STOCK 800,000 $4.99 $3,994,880.00
Disclosure

SEC source: 0001213900-19-003242 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,831,267

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 02/25/2019 at prices ranging from $4.80 to $5.31, inclusive, on 02/26/2019 at prices ranging from $5.00 to $5.08, inclusive, and on 02/27/2019 at prices ranging from $4.40 to $4.675, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within each of the ranges set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

Read SEC document
September 06, 2018 Filed Sep 7, 2018 18:27 UTC Karyopharm Therapeutics Inc. KPTI · Entity 781 SaleCOMMON STOCK 4,800 $20.52 $98,473.92
Disclosure

SEC source: 0001213900-18-012296 · ownership.xml · nonDerivative · entry 2

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,631,267

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 09/05/2018 at prices ranging from $21.00 to $21.50, inclusive, and on 09/06/2018 at prices ranging from $20.50 to $20.605, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

Read SEC document
September 05, 2018 Filed Sep 7, 2018 18:27 UTC Karyopharm Therapeutics Inc. KPTI · Entity 781 SaleCOMMON STOCK 160,000 $21.06 $3,370,256.00
Disclosure

SEC source: 0001213900-18-012296 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,636,067

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 09/05/2018 at prices ranging from $21.00 to $21.50, inclusive, and on 09/06/2018 at prices ranging from $20.50 to $20.605, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

Read SEC document
September 04, 2018 Filed Sep 4, 2018 18:59 UTC Karyopharm Therapeutics Inc. KPTI · Entity 781 SaleCOMMON STOCK 40,000 $20.60 $824,072.00
Disclosure

SEC source: 0001213900-18-012091 · ownership.xml · nonDerivative · entry 3

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,796,067

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 08/30/2018 at prices ranging from $20.31 to $21.61, inclusive, on 08/31/2018 at prices ranging from $21.00 to $21.22, inclusive, and on 09/04/2018 at prices ranging from $20.50 to $20.82, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

Read SEC document
August 31, 2018 Filed Sep 4, 2018 18:59 UTC Karyopharm Therapeutics Inc. KPTI · Entity 781 SaleCOMMON STOCK 11,468 $21.05 $241,395.67
Disclosure

SEC source: 0001213900-18-012091 · ownership.xml · nonDerivative · entry 2

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,836,067

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 08/30/2018 at prices ranging from $20.31 to $21.61, inclusive, on 08/31/2018 at prices ranging from $21.00 to $21.22, inclusive, and on 09/04/2018 at prices ranging from $20.50 to $20.82, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

Read SEC document
August 30, 2018 Filed Sep 4, 2018 18:59 UTC Karyopharm Therapeutics Inc. KPTI · Entity 781 SaleCOMMON STOCK 200,000 $21.00 $4,199,900.00
Disclosure

SEC source: 0001213900-18-012091 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,847,535

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 08/30/2018 at prices ranging from $20.31 to $21.61, inclusive, on 08/31/2018 at prices ranging from $21.00 to $21.22, inclusive, and on 09/04/2018 at prices ranging from $20.50 to $20.82, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

Read SEC document
August 29, 2018 Filed Aug 29, 2018 20:12 UTC Karyopharm Therapeutics Inc. KPTI · Entity 781 SaleCOMMON STOCK 200,000 $19.59 $3,918,280.00
Disclosure

SEC source: 0001213900-18-011892 · ownership.xml · nonDerivative · entry 2

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,047,535

F1 · shares: The prices reported in Column 4 are weighted average prices. The shares were sold on 08/27/2018 at prices ranging from $18.50 to $18.65, inclusive, and on 08/29/2018 at prices ranging from $19.00 to $20.01, inclusive.

F2 · shares: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

Read SEC document
August 27, 2018 Filed Aug 29, 2018 20:12 UTC Karyopharm Therapeutics Inc. KPTI · Entity 781 SaleCOMMON STOCK 14,026 $18.52 $259,775.55
Disclosure

SEC source: 0001213900-18-011892 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,247,535

F1 · shares: The prices reported in Column 4 are weighted average prices. The shares were sold on 08/27/2018 at prices ranging from $18.50 to $18.65, inclusive, and on 08/29/2018 at prices ranging from $19.00 to $20.01, inclusive.

F2 · shares: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

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August 10, 2018 Filed Aug 14, 2018 19:08 UTC Karyopharm Therapeutics Inc. KPTI · Entity 781 SaleCOMMON STOCK 702 $18.50 $12,987.00
Disclosure

SEC source: 0001213900-18-011094 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,261,561

F1 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F2 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F3 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

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August 09, 2018 Filed Aug 9, 2018 20:24 UTC Karyopharm Therapeutics Inc. KPTI · Entity 781 SaleCOMMON STOCK 67,474 $18.51 $1,248,781.80
Disclosure

SEC source: 0001213900-18-010635 · ownership.xml · nonDerivative · entry 3

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,262,263

F1 · price: The prices reported in Column 4 for the sales on 08/08/2018 and 08/09/2018 are weighted average prices. The shares were sold on 08/08/2018 at prices ranging from $18.6 to $18.625, inclusive, and on 08/09/2018 at prices ranging from $18.5 to $18.705, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

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August 08, 2018 Filed Aug 9, 2018 20:24 UTC Karyopharm Therapeutics Inc. KPTI · Entity 781 SaleCOMMON STOCK 2,800 $18.61 $52,098.48
Disclosure

SEC source: 0001213900-18-010635 · ownership.xml · nonDerivative · entry 2

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,329,737

F1 · price: The prices reported in Column 4 for the sales on 08/08/2018 and 08/09/2018 are weighted average prices. The shares were sold on 08/08/2018 at prices ranging from $18.6 to $18.625, inclusive, and on 08/09/2018 at prices ranging from $18.5 to $18.705, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

Read SEC document
August 07, 2018 Filed Aug 9, 2018 20:24 UTC Karyopharm Therapeutics Inc. KPTI · Entity 781 SaleCOMMON STOCK 10,602 $18.60 $197,197.20
Disclosure

SEC source: 0001213900-18-010635 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,332,537

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

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July 25, 2018 Filed Jul 25, 2018 19:55 UTC Karyopharm Therapeutics Inc. KPTI · Entity 781 SaleCOMMON STOCK 895 $18.52 $16,571.01
Disclosure

SEC source: 0001213900-18-009659 · ownership.xml · nonDerivative · entry 3

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,343,139

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 07/23/2018 at prices ranging from $18.47 to $18.91, inclusive, on 07/24/2018 at prices ranging from $18.6 to $18.72, inclusive, and on 07/25/2018 at prices ranging from $18.5 to $18.59, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

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July 24, 2018 Filed Jul 25, 2018 19:55 UTC Karyopharm Therapeutics Inc. KPTI · Entity 781 SaleCOMMON STOCK 9,144 $18.63 $170,341.75
Disclosure

SEC source: 0001213900-18-009659 · ownership.xml · nonDerivative · entry 2

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,344,034

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 07/23/2018 at prices ranging from $18.47 to $18.91, inclusive, on 07/24/2018 at prices ranging from $18.6 to $18.72, inclusive, and on 07/25/2018 at prices ranging from $18.5 to $18.59, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

Read SEC document
July 23, 2018 Filed Jul 25, 2018 19:55 UTC Karyopharm Therapeutics Inc. KPTI · Entity 781 SaleCOMMON STOCK 20,000 $18.66 $373,222.00
Disclosure

SEC source: 0001213900-18-009659 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,353,178

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 07/23/2018 at prices ranging from $18.47 to $18.91, inclusive, on 07/24/2018 at prices ranging from $18.6 to $18.72, inclusive, and on 07/25/2018 at prices ranging from $18.5 to $18.59, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

Read SEC document
July 20, 2018 Filed Jul 23, 2018 17:00 UTC Karyopharm Therapeutics Inc. KPTI · Entity 781 SaleCOMMON STOCK 26,742 $19.21 $513,804.74
Disclosure

SEC source: 0001213900-18-009536 · ownership.xml · nonDerivative · entry 2

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,373,178

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 07/19/2018 at prices ranging from $18.6 to $19.305, inclusive, and on 07/20/2018 at prices ranging from $19.2 to $19.28, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

Read SEC document
July 19, 2018 Filed Jul 23, 2018 17:00 UTC Karyopharm Therapeutics Inc. KPTI · Entity 781 SaleCOMMON STOCK 100,000 $18.90 $1,889,940.00
Disclosure

SEC source: 0001213900-18-009536 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,399,920

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 07/19/2018 at prices ranging from $18.6 to $19.305, inclusive, and on 07/20/2018 at prices ranging from $19.2 to $19.28, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

Read SEC document
July 18, 2018 Filed Jul 18, 2018 19:34 UTC Karyopharm Therapeutics Inc. KPTI · Entity 781 SaleCOMMON STOCK 30,000 $18.53 $556,005.00
Disclosure

SEC source: 0001213900-18-009395 · ownership.xml · nonDerivative · entry 3

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,499,920

F1 · price: The prices reported in Column 4 for the sales on 07/16/2018 and 07/18/2018 are weighted average prices. The shares were sold on 07/16/2018 at prices ranging from $18.5 to $18.57, inclusive, and on 07/18/2018 at prices ranging from $18.5 to $18.615, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

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July 17, 2018 Filed Jul 18, 2018 19:34 UTC Karyopharm Therapeutics Inc. KPTI · Entity 781 SaleCOMMON STOCK 17,346 $18.50 $320,901.00
Disclosure

SEC source: 0001213900-18-009395 · ownership.xml · nonDerivative · entry 2

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,529,920

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

Read SEC document
July 16, 2018 Filed Jul 18, 2018 19:34 UTC Karyopharm Therapeutics Inc. KPTI · Entity 781 SaleCOMMON STOCK 2,654 $18.52 $49,160.84
Disclosure

SEC source: 0001213900-18-009395 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,547,266

F1 · price: The prices reported in Column 4 for the sales on 07/16/2018 and 07/18/2018 are weighted average prices. The shares were sold on 07/16/2018 at prices ranging from $18.5 to $18.57, inclusive, and on 07/18/2018 at prices ranging from $18.5 to $18.615, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.