Chione Ltd

SEC source: 0001213900-23-052442 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Nikolaou Anastasis · CIK 0001954186 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,848,632

F1 · price: The price reported in Column 4 is a weighted average price. The shares referred to in Column 4 were sold at $12.925 and $12.93.

F2 · ownership.direct: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within each of the ranges set forth in footnote 1 above.

F3 · ownership.direct: Shares owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and Anastasis Nikolaou, and its sole shareholder, Wiaczeslaw Smolokowski, may be deemed to share beneficial ownership of the shares directly owned by Chione.

F4 · ownership.direct: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Each reporting person disclaims beneficial ownership of the securities covered by this statement, except to the extent of the pecuniary interest of such person in such securities.

F5 · ownership.direct: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-23-050160 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Nikolaou Anastasis · CIK 0001954186 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,848,648

F1 · price: The price reported in Column 4 is a weighted average price. The shares referred to in Column 4 were sold at prices ranging from $12.04 to $12.50, inclusive.

F2 · ownership.direct: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within each of the ranges set forth in footnote 1 above.

F3 · ownership.direct: Shares owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and Anastasis Nikolaou, and its sole shareholder, Wiaczeslaw Smolokowski, may be deemed to share beneficial ownership of the shares directly owned by Chione.

F4 · ownership.direct: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Each reporting person disclaims beneficial ownership of the securities covered by this statement, except to the extent of the pecuniary interest of such person in such securities.

F5 · ownership.direct: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-23-049014 · ownership.xml · nonDerivative · entry 3

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Nikolaou Anastasis · CIK 0001954186 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,850,704

F1 · price: The prices reported in Column 4 are weighted average prices. The 2,000 shares referred to in the first row of Column 4 were sold at prices ranging from $12.165 to $12.49, inclusive. The 3,000 shares referred to in the second row of Column 4 were sold at prices ranging from $12.03 to $12.55, inclusive. The 893 shares referred to in the third row of Column 4 were sold at prices ranging from $12.01 T0 $12.47, inclusive.

F2 · ownership.direct: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within each of the ranges set forth in footnote 1 above.

F3 · ownership.direct: Shares owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and Anastasis Nikolaou, and its sole shareholder, Wiaczeslaw Smolokowski, may be deemed to share beneficial ownership of the shares directly owned by Chione.

F4 · ownership.direct: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Each reporting person disclaims beneficial ownership of the securities covered by this statement, except to the extent of the pecuniary interest of such person in such securities.

F5 · ownership.direct: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-23-049014 · ownership.xml · nonDerivative · entry 2

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Nikolaou Anastasis · CIK 0001954186 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,851,597

F1 · price: The prices reported in Column 4 are weighted average prices. The 2,000 shares referred to in the first row of Column 4 were sold at prices ranging from $12.165 to $12.49, inclusive. The 3,000 shares referred to in the second row of Column 4 were sold at prices ranging from $12.03 to $12.55, inclusive. The 893 shares referred to in the third row of Column 4 were sold at prices ranging from $12.01 T0 $12.47, inclusive.

F2 · ownership.direct: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within each of the ranges set forth in footnote 1 above.

F3 · ownership.direct: Shares owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and Anastasis Nikolaou, and its sole shareholder, Wiaczeslaw Smolokowski, may be deemed to share beneficial ownership of the shares directly owned by Chione.

F4 · ownership.direct: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Each reporting person disclaims beneficial ownership of the securities covered by this statement, except to the extent of the pecuniary interest of such person in such securities.

F5 · ownership.direct: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-23-049014 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Nikolaou Anastasis · CIK 0001954186 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,854,597

F1 · price: The prices reported in Column 4 are weighted average prices. The 2,000 shares referred to in the first row of Column 4 were sold at prices ranging from $12.165 to $12.49, inclusive. The 3,000 shares referred to in the second row of Column 4 were sold at prices ranging from $12.03 to $12.55, inclusive. The 893 shares referred to in the third row of Column 4 were sold at prices ranging from $12.01 T0 $12.47, inclusive.

F2 · ownership.direct: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within each of the ranges set forth in footnote 1 above.

F3 · ownership.direct: Shares owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and Anastasis Nikolaou, and its sole shareholder, Wiaczeslaw Smolokowski, may be deemed to share beneficial ownership of the shares directly owned by Chione.

F4 · ownership.direct: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Each reporting person disclaims beneficial ownership of the securities covered by this statement, except to the extent of the pecuniary interest of such person in such securities.

F5 · ownership.direct: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-22-074313 · ownership.xml · derivative · entry 5

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Nikolaou Anastasis · CIK 0001954186 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 10,657 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Series A-1 Preferred Stock and Series B Preferred Stock (collectively, the "Preferred Stock") was automatically converted into Common Stock on a 2.466 to 1 share basis, without payment of further consideration, in connection with the closing of the issuer's initial public offering. The conversion prices per share of Common Stock for the Series A-1 Preferred Stock and Series B Preferred Stock were $5.6225 and $14.0745, respectively. The Preferred Stock had no expiration date.

F1 · derivative.exercise_date: Each share of Series A-1 Preferred Stock and Series B Preferred Stock (collectively, the "Preferred Stock") was automatically converted into Common Stock on a 2.466 to 1 share basis, without payment of further consideration, in connection with the closing of the issuer's initial public offering. The conversion prices per share of Common Stock for the Series A-1 Preferred Stock and Series B Preferred Stock were $5.6225 and $14.0745, respectively. The Preferred Stock had no expiration date.

F1 · derivative.expiration_date: Each share of Series A-1 Preferred Stock and Series B Preferred Stock (collectively, the "Preferred Stock") was automatically converted into Common Stock on a 2.466 to 1 share basis, without payment of further consideration, in connection with the closing of the issuer's initial public offering. The conversion prices per share of Common Stock for the Series A-1 Preferred Stock and Series B Preferred Stock were $5.6225 and $14.0745, respectively. The Preferred Stock had no expiration date.

F2 · ownership.direct: Shares owned directly by Chione Limited ("Chione").

F3 · ownership.direct: Chione's directors, Marcin Czernik, Andreas Hadjimichael and Anastasis Nikolaou, and its sole shareholder, Wiaczeslaw Smolokowski, may be deemed to share beneficial ownership of the shares directly owned by Chione.

F4 · ownership.direct: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Each reporting person disclaims beneficial ownership of the securities covered by this statement, except to the extent of the pecuniary interest of such person in such securities.

F5 · ownership.direct: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-22-074313 · ownership.xml · derivative · entry 4

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Nikolaou Anastasis · CIK 0001954186 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,445,940 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each share of Series A-1 Preferred Stock and Series B Preferred Stock (collectively, the "Preferred Stock") was automatically converted into Common Stock on a 2.466 to 1 share basis, without payment of further consideration, in connection with the closing of the issuer's initial public offering. The conversion prices per share of Common Stock for the Series A-1 Preferred Stock and Series B Preferred Stock were $5.6225 and $14.0745, respectively. The Preferred Stock had no expiration date.

F1 · derivative.exercise_date: Each share of Series A-1 Preferred Stock and Series B Preferred Stock (collectively, the "Preferred Stock") was automatically converted into Common Stock on a 2.466 to 1 share basis, without payment of further consideration, in connection with the closing of the issuer's initial public offering. The conversion prices per share of Common Stock for the Series A-1 Preferred Stock and Series B Preferred Stock were $5.6225 and $14.0745, respectively. The Preferred Stock had no expiration date.

F1 · derivative.expiration_date: Each share of Series A-1 Preferred Stock and Series B Preferred Stock (collectively, the "Preferred Stock") was automatically converted into Common Stock on a 2.466 to 1 share basis, without payment of further consideration, in connection with the closing of the issuer's initial public offering. The conversion prices per share of Common Stock for the Series A-1 Preferred Stock and Series B Preferred Stock were $5.6225 and $14.0745, respectively. The Preferred Stock had no expiration date.

F2 · ownership.direct: Shares owned directly by Chione Limited ("Chione").

F3 · ownership.direct: Chione's directors, Marcin Czernik, Andreas Hadjimichael and Anastasis Nikolaou, and its sole shareholder, Wiaczeslaw Smolokowski, may be deemed to share beneficial ownership of the shares directly owned by Chione.

F4 · ownership.direct: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Each reporting person disclaims beneficial ownership of the securities covered by this statement, except to the extent of the pecuniary interest of such person in such securities.

F5 · ownership.direct: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-22-074313 · ownership.xml · nonDerivative · entry 3

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Nikolaou Anastasis · CIK 0001954186 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,856,597

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of Series A-1 Preferred Stock and Series B Preferred Stock (collectively, the "Preferred Stock") was automatically converted into Common Stock on a 2.466 to 1 share basis, without payment of further consideration, in connection with the closing of the issuer's initial public offering. The conversion prices per share of Common Stock for the Series A-1 Preferred Stock and Series B Preferred Stock were $5.6225 and $14.0745, respectively. The Preferred Stock had no expiration date.

F2 · ownership.direct: Shares owned directly by Chione Limited ("Chione").

F3 · ownership.direct: Chione's directors, Marcin Czernik, Andreas Hadjimichael and Anastasis Nikolaou, and its sole shareholder, Wiaczeslaw Smolokowski, may be deemed to share beneficial ownership of the shares directly owned by Chione.

F4 · ownership.direct: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Each reporting person disclaims beneficial ownership of the securities covered by this statement, except to the extent of the pecuniary interest of such person in such securities.

F5 · ownership.direct: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-22-074313 · ownership.xml · nonDerivative · entry 2

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Nikolaou Anastasis · CIK 0001954186 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,856,597

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each share of Series A-1 Preferred Stock and Series B Preferred Stock (collectively, the "Preferred Stock") was automatically converted into Common Stock on a 2.466 to 1 share basis, without payment of further consideration, in connection with the closing of the issuer's initial public offering. The conversion prices per share of Common Stock for the Series A-1 Preferred Stock and Series B Preferred Stock were $5.6225 and $14.0745, respectively. The Preferred Stock had no expiration date.

F2 · ownership.direct: Shares owned directly by Chione Limited ("Chione").

F3 · ownership.direct: Chione's directors, Marcin Czernik, Andreas Hadjimichael and Anastasis Nikolaou, and its sole shareholder, Wiaczeslaw Smolokowski, may be deemed to share beneficial ownership of the shares directly owned by Chione.

F4 · ownership.direct: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Each reporting person disclaims beneficial ownership of the securities covered by this statement, except to the extent of the pecuniary interest of such person in such securities.

F5 · ownership.direct: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-22-074313 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Nikolaou Anastasis · CIK 0001954186 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,856,597

F2 · ownership.direct: Shares owned directly by Chione Limited ("Chione").

F3 · ownership.direct: Chione's directors, Marcin Czernik, Andreas Hadjimichael and Anastasis Nikolaou, and its sole shareholder, Wiaczeslaw Smolokowski, may be deemed to share beneficial ownership of the shares directly owned by Chione.

F4 · ownership.direct: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Each reporting person disclaims beneficial ownership of the securities covered by this statement, except to the extent of the pecuniary interest of such person in such securities.

F5 · ownership.direct: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-19-003551 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,000,000

F1 · price: The price reported in Column 4 is a weighted average price. The shares were sold at prices ranging from $4.04 to $4.25, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-19-003242 · ownership.xml · nonDerivative · entry 3

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,149,624

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 02/25/2019 at prices ranging from $4.80 to $5.31, inclusive, on 02/26/2019 at prices ranging from $5.00 to $5.08, inclusive, and on 02/27/2019 at prices ranging from $4.40 to $4.675, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within each of the ranges set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-19-003242 · ownership.xml · nonDerivative · entry 2

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,707,867

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 02/25/2019 at prices ranging from $4.80 to $5.31, inclusive, on 02/26/2019 at prices ranging from $5.00 to $5.08, inclusive, and on 02/27/2019 at prices ranging from $4.40 to $4.675, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within each of the ranges set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-19-003242 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,831,267

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 02/25/2019 at prices ranging from $4.80 to $5.31, inclusive, on 02/26/2019 at prices ranging from $5.00 to $5.08, inclusive, and on 02/27/2019 at prices ranging from $4.40 to $4.675, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within each of the ranges set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-18-012296 · ownership.xml · nonDerivative · entry 2

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,631,267

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 09/05/2018 at prices ranging from $21.00 to $21.50, inclusive, and on 09/06/2018 at prices ranging from $20.50 to $20.605, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-18-012296 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,636,067

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 09/05/2018 at prices ranging from $21.00 to $21.50, inclusive, and on 09/06/2018 at prices ranging from $20.50 to $20.605, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-18-012091 · ownership.xml · nonDerivative · entry 3

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,796,067

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 08/30/2018 at prices ranging from $20.31 to $21.61, inclusive, on 08/31/2018 at prices ranging from $21.00 to $21.22, inclusive, and on 09/04/2018 at prices ranging from $20.50 to $20.82, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-18-012091 · ownership.xml · nonDerivative · entry 2

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,836,067

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 08/30/2018 at prices ranging from $20.31 to $21.61, inclusive, on 08/31/2018 at prices ranging from $21.00 to $21.22, inclusive, and on 09/04/2018 at prices ranging from $20.50 to $20.82, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-18-012091 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,847,535

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 08/30/2018 at prices ranging from $20.31 to $21.61, inclusive, on 08/31/2018 at prices ranging from $21.00 to $21.22, inclusive, and on 09/04/2018 at prices ranging from $20.50 to $20.82, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-18-011892 · ownership.xml · nonDerivative · entry 2

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,047,535

F1 · shares: The prices reported in Column 4 are weighted average prices. The shares were sold on 08/27/2018 at prices ranging from $18.50 to $18.65, inclusive, and on 08/29/2018 at prices ranging from $19.00 to $20.01, inclusive.

F2 · shares: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-18-011892 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,247,535

F1 · shares: The prices reported in Column 4 are weighted average prices. The shares were sold on 08/27/2018 at prices ranging from $18.50 to $18.65, inclusive, and on 08/29/2018 at prices ranging from $19.00 to $20.01, inclusive.

F2 · shares: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-18-011094 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,261,561

F1 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F2 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F3 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-18-010635 · ownership.xml · nonDerivative · entry 3

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,262,263

F1 · price: The prices reported in Column 4 for the sales on 08/08/2018 and 08/09/2018 are weighted average prices. The shares were sold on 08/08/2018 at prices ranging from $18.6 to $18.625, inclusive, and on 08/09/2018 at prices ranging from $18.5 to $18.705, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-18-010635 · ownership.xml · nonDerivative · entry 2

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,329,737

F1 · price: The prices reported in Column 4 for the sales on 08/08/2018 and 08/09/2018 are weighted average prices. The shares were sold on 08/08/2018 at prices ranging from $18.6 to $18.625, inclusive, and on 08/09/2018 at prices ranging from $18.5 to $18.705, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-18-010635 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,332,537

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-18-009659 · ownership.xml · nonDerivative · entry 3

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,343,139

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 07/23/2018 at prices ranging from $18.47 to $18.91, inclusive, on 07/24/2018 at prices ranging from $18.6 to $18.72, inclusive, and on 07/25/2018 at prices ranging from $18.5 to $18.59, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-18-009659 · ownership.xml · nonDerivative · entry 2

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,344,034

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 07/23/2018 at prices ranging from $18.47 to $18.91, inclusive, on 07/24/2018 at prices ranging from $18.6 to $18.72, inclusive, and on 07/25/2018 at prices ranging from $18.5 to $18.59, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-18-009659 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,353,178

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 07/23/2018 at prices ranging from $18.47 to $18.91, inclusive, on 07/24/2018 at prices ranging from $18.6 to $18.72, inclusive, and on 07/25/2018 at prices ranging from $18.5 to $18.59, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-18-009536 · ownership.xml · nonDerivative · entry 2

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,373,178

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 07/19/2018 at prices ranging from $18.6 to $19.305, inclusive, and on 07/20/2018 at prices ranging from $19.2 to $19.28, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-18-009536 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,399,920

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 07/19/2018 at prices ranging from $18.6 to $19.305, inclusive, and on 07/20/2018 at prices ranging from $19.2 to $19.28, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-18-009395 · ownership.xml · nonDerivative · entry 3

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,499,920

F1 · price: The prices reported in Column 4 for the sales on 07/16/2018 and 07/18/2018 are weighted average prices. The shares were sold on 07/16/2018 at prices ranging from $18.5 to $18.57, inclusive, and on 07/18/2018 at prices ranging from $18.5 to $18.615, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-18-009395 · ownership.xml · nonDerivative · entry 2

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,529,920

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

SEC source: 0001213900-18-009395 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,547,266

F1 · price: The prices reported in Column 4 for the sales on 07/16/2018 and 07/18/2018 are weighted average prices. The shares were sold on 07/16/2018 at prices ranging from $18.5 to $18.57, inclusive, and on 07/18/2018 at prices ranging from $18.5 to $18.615, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.