TELA

SEC source: 0001062993-23-012779 · form4.xml · nonDerivative · entry 1

O'Brien Federica F. · CIK 0001140119 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,270

F1 · shares: These restricted stock units vest on the earlier of (a) June 1, 2024, (b) the next annual meeting of stockholders, or (c) the occurrence of a Change in Control (as defined in the Issuer's Amended and Restated 2019 Equity Incentive Plan), in each case subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0001062993-23-012778 · form4.xml · derivative · entry 2

COLLERAN LISA N · CIK 0001212312 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,360

Underlying: Common Stock · 5,360 shares

Expires 2033-06-01

F2 · derivative.exercise_date: The option vests on the earlier of (a) June 1, 2024, (b) the next annual meeting of stockholders, or (c) the occurrence of a Change in Control (as defined in the Issuer's Amended and Restated 2019 Equity Incentive Plan), in each case subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0001062993-23-012778 · form4.xml · nonDerivative · entry 1

COLLERAN LISA N · CIK 0001212312 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,270

F1 · shares: These restricted stock units vest on the earlier of (a) June 1, 2024, (b) the next annual meeting of stockholders, or (c) the occurrence of a Change in Control (as defined in the Issuer's Amended and Restated 2019 Equity Incentive Plan), in each case subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0001062993-23-012777 · form4.xml · derivative · entry 2

EVANS DOUGLAS G · CIK 0001225164 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,360

Underlying: Common Stock · 5,360 shares

Expires 2033-06-01

F2 · derivative.exercise_date: The option vests on the earlier of (a) June 1, 2024, (b) the next annual meeting of stockholders, or (c) the occurrence of a Change in Control (as defined in the Issuer's Amended and Restated 2019 Equity Incentive Plan), in each case subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0001062993-23-012777 · form4.xml · nonDerivative · entry 1

EVANS DOUGLAS G · CIK 0001225164 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,270

F1 · shares: These restricted stock units vest on the earlier of (a) June 1, 2024, (b) the next annual meeting of stockholders, or (c) the occurrence of a Change in Control (as defined in the Issuer's Amended and Restated 2019 Equity Incentive Plan), in each case subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0001062993-23-012774 · form4.xml · derivative · entry 2

Burgess Vincent J · CIK 0001365408 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,360

Underlying: Common Stock · 5,360 shares

Expires 2033-06-01

F2 · derivative.exercise_date: The option vests on the earlier of (a) June 1, 2024, (b) the next annual meeting of stockholders, or (c) the occurrence of a Change in Control (as defined in the Issuer's Amended and Restated 2019 Equity Incentive Plan), in each case subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0001062993-23-012774 · form4.xml · nonDerivative · entry 1

Burgess Vincent J · CIK 0001365408 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,130

F1 · shares: These restricted stock units vest on the earlier of (a) June 1, 2024, (b) the next annual meeting of stockholders, or (c) the occurrence of a Change in Control (as defined in the Issuer's Amended and Restated 2019 Equity Incentive Plan), in each case subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0001062993-23-012776 · form4.xml · derivative · entry 2

Azarbarzin Kurt · CIK 0001792303 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,360

Underlying: Common Stock · 5,360 shares

Expires 2033-06-01

F2 · derivative.exercise_date: The option vests on the earlier of (a) June 1, 2024, (b) the next annual meeting of stockholders, or (c) the occurrence of a Change in Control (as defined in the Issuer's Amended and Restated 2019 Equity Incentive Plan), in each case subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0001062993-23-012776 · form4.xml · nonDerivative · entry 1

Azarbarzin Kurt · CIK 0001792303 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,270

F1 · shares: These restricted stock units vest on the earlier of (a) June 1, 2024, (b) the next annual meeting of stockholders, or (c) the occurrence of a Change in Control (as defined in the Issuer's Amended and Restated 2019 Equity Incentive Plan), in each case subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0001062993-23-012775 · form4.xml · derivative · entry 2

Nosenzo John · CIK 0001835973 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,360

Underlying: Common Stock · 5,360 shares

Expires 2033-06-01

F2 · derivative.exercise_date: The option vests on the earlier of (a) June 1, 2024, (b) the next annual meeting of stockholders, or (c) the occurrence of a Change in Control (as defined in the Issuer's Amended and Restated 2019 Equity Incentive Plan), in each case subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0001062993-23-012775 · form4.xml · nonDerivative · entry 1

Nosenzo John · CIK 0001835973 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,270

F1 · shares: These restricted stock units vest on the earlier of (a) June 1, 2024, (b) the next annual meeting of stockholders, or (c) the occurrence of a Change in Control (as defined in the Issuer's Amended and Restated 2019 Equity Incentive Plan), in each case subject to the Reporting Person's continued service through the applicable vesting date.

SEC source: 0000947871-23-000484 · ownership.xml · nonDerivative · entry 3

ORBIMED ADVISORS LLC · CIK 0001055951 · 10% owner

OrbiMed Capital GP IV LLC · CIK 0001502240 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 2,835,542

F1 · ownership.nature: These securities are held of record by OrbiMed Private Investments IV, LP ("OPI IV"). OrbiMed Capital GP IV LLC ("GP IV") is the general partner of OPI IV and OrbiMed Advisors LLC ("OrbiMed Advisors") is the managing member of GP IV. By virtue of such relationships, OrbiMed Advisors and GP IV may be deemed to have voting power and investment power over the securities held by OPI IV and, as a result, may be deemed to have beneficial ownership over such securities. OrbiMed Advisors exercises voting and investment power through a management committee comprised of Carl L. Gordon, Sven H. Borho, and W. Carter Neild, each of whom disclaims beneficial ownership of the securities held by OPI IV.

F2 · ownership.nature: Each of OrbiMed Advisors and GP IV disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any such person or entity, including the Reporting Persons, is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose.

SEC source: 0000947871-23-000484 · ownership.xml · nonDerivative · entry 2

ORBIMED ADVISORS LLC · CIK 0001055951 · 10% owner

OrbiMed Capital GP IV LLC · CIK 0001502240 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 2,863,242

F1 · ownership.nature: These securities are held of record by OrbiMed Private Investments IV, LP ("OPI IV"). OrbiMed Capital GP IV LLC ("GP IV") is the general partner of OPI IV and OrbiMed Advisors LLC ("OrbiMed Advisors") is the managing member of GP IV. By virtue of such relationships, OrbiMed Advisors and GP IV may be deemed to have voting power and investment power over the securities held by OPI IV and, as a result, may be deemed to have beneficial ownership over such securities. OrbiMed Advisors exercises voting and investment power through a management committee comprised of Carl L. Gordon, Sven H. Borho, and W. Carter Neild, each of whom disclaims beneficial ownership of the securities held by OPI IV.

F2 · ownership.nature: Each of OrbiMed Advisors and GP IV disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any such person or entity, including the Reporting Persons, is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose.

SEC source: 0000947871-23-000484 · ownership.xml · nonDerivative · entry 1

ORBIMED ADVISORS LLC · CIK 0001055951 · 10% owner

OrbiMed Capital GP IV LLC · CIK 0001502240 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 2,891,542

F1 · ownership.nature: These securities are held of record by OrbiMed Private Investments IV, LP ("OPI IV"). OrbiMed Capital GP IV LLC ("GP IV") is the general partner of OPI IV and OrbiMed Advisors LLC ("OrbiMed Advisors") is the managing member of GP IV. By virtue of such relationships, OrbiMed Advisors and GP IV may be deemed to have voting power and investment power over the securities held by OPI IV and, as a result, may be deemed to have beneficial ownership over such securities. OrbiMed Advisors exercises voting and investment power through a management committee comprised of Carl L. Gordon, Sven H. Borho, and W. Carter Neild, each of whom disclaims beneficial ownership of the securities held by OPI IV.

F2 · ownership.nature: Each of OrbiMed Advisors and GP IV disclaims beneficial ownership of the securities reported herein for purposes of Rule 16a-1(a) under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), except to the extent of its pecuniary interest therein, if any. This report shall not be deemed an admission that any such person or entity, including the Reporting Persons, is a beneficial owner of such securities for the purpose of Section 16 of the Exchange Act, or for any other purpose.

SEC source: 0001062993-23-008665 · form4.xml · nonDerivative · entry 1

Talmo Paul · CIK 0001899089 · Chief Strategic Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,976

F1 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001062993-23-008666 · form4.xml · nonDerivative · entry 1

Murphy Peter C. · CIK 0001801542 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,987

F1 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001062993-23-008668 · form4.xml · nonDerivative · entry 1

KOBLISH ANTONY · CIK 0001195881 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 292,634

F1 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001062993-23-008667 · form4.xml · nonDerivative · entry 1

Smeykal Megan · CIK 0001899973 · Chief Accounting Officer · Controller

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,431

F1 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001062993-23-008208 · form4.xml · derivative · entry 2

Burgess Vincent J · CIK 0001365408 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 4,860 shares

Expires 2023-04-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001062993-23-008208 · form4.xml · nonDerivative · entry 1

Burgess Vincent J · CIK 0001365408 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,995

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001062993-23-005026 · form4.xml · nonDerivative · entry 3

Talmo Paul · CIK 0001899089 · Chief Strategic Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,163

F2 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of RSUs.

SEC source: 0001062993-23-005027 · form4.xml · nonDerivative · entry 3

Murphy Peter C. · CIK 0001801542 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 38,150

F2 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of RSUs.

SEC source: 0001062993-23-005025 · form4.xml · nonDerivative · entry 2

KOBLISH ANTONY · CIK 0001195881 · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 293,019

F2 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of RSUs.

SEC source: 0001062993-23-005024 · form4.xml · nonDerivative · entry 2

Smeykal Megan · CIK 0001899973 · Chief Accounting Officer · Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,527

F1 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001062993-23-005026 · form4.xml · derivative · entry 4

Talmo Paul · CIK 0001899089 · Chief Strategic Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,400

Underlying: Common Stock · 26,400 shares

Expires 2033-02-23

F3 · derivative.exercise_date: The option vests 25% on February 23, 2024, with the remaining 75% vesting in equal monthly installments on the last day of each of the 36 calendar months immediately following such date, subject to the Reporting Person's continued service through the applicable vesting dates.

SEC source: 0001062993-23-005026 · form4.xml · nonDerivative · entry 2

Talmo Paul · CIK 0001899089 · Chief Strategic Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 57,195

F2 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of RSUs.

SEC source: 0001062993-23-005026 · form4.xml · nonDerivative · entry 1

Talmo Paul · CIK 0001899089 · Chief Strategic Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 58,262

F1 · shares: These restricted stock units ("RSUs") will vest in four equal annual installments beginning on February 23, 2024, subject to the Reporting Person's continuous service through the applicable vesting dates.

SEC source: 0001062993-23-005027 · form4.xml · derivative · entry 4

Murphy Peter C. · CIK 0001801542 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,400

Underlying: Common Stock · 26,400 shares

Expires 2033-02-23

F3 · derivative.exercise_date: The option vests 25% on February 23, 2024, with the remaining 75% vesting in equal monthly installments on the last day of each of the 36 calendar months immediately following such date, subject to the Reporting Person's continued service through the applicable vesting dates.

SEC source: 0001062993-23-005027 · form4.xml · nonDerivative · entry 2

Murphy Peter C. · CIK 0001801542 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,090

F2 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of RSUs.

SEC source: 0001062993-23-005027 · form4.xml · nonDerivative · entry 1

Murphy Peter C. · CIK 0001801542 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,996

F1 · shares: These restricted stock units ("RSUs") will vest in four equal annual installments beginning on February 23, 2024, subject to the Reporting Person's continuous service through the applicable vesting dates.

SEC source: 0001062993-23-005025 · form4.xml · derivative · entry 3

KOBLISH ANTONY · CIK 0001195881 · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 96,100

Underlying: Common Stock · 96,100 shares

Expires 2033-02-23

F3 · derivative.exercise_date: The option vests 25% on February 23, 2024, with the remaining 75% vesting in equal monthly installments on the last day of each of the 36 calendar months immediately following such date, subject to the Reporting Person's continued service through the applicable vesting dates.

SEC source: 0001062993-23-005025 · form4.xml · nonDerivative · entry 1

KOBLISH ANTONY · CIK 0001195881 · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 299,053

F1 · shares: These restricted stock units ("RSUs") will vest in four equal annual installments beginning on February 23, 2024, subject to the Reporting Person's continuous service through the applicable vesting dates.

SEC source: 0001062993-23-005028 · form4.xml · derivative · entry 3

Cuca Roberto · CIK 0001591474 · COO and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,700

Underlying: Common Stock · 27,700 shares

Expires 2033-02-23

F3 · derivative.exercise_date: The option vests 25% on February 23, 2024, with the remaining 75% vesting in equal monthly installments on the last day of each of the 36 calendar months immediately following such date, subject to the Reporting Person's continued service through the applicable vesting dates.

SEC source: 0001062993-23-005028 · form4.xml · nonDerivative · entry 2

Cuca Roberto · CIK 0001591474 · COO and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 51,292

F2 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of RSUs.

SEC source: 0001062993-23-005028 · form4.xml · nonDerivative · entry 1

Cuca Roberto · CIK 0001591474 · COO and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,592

F1 · shares: These restricted stock units ("RSUs") will vest in four equal annual installments beginning on February 23, 2024, subject to the Reporting Person's continuous service through the applicable vesting dates.

SEC source: 0001062993-23-005024 · form4.xml · nonDerivative · entry 1

Smeykal Megan · CIK 0001899973 · Chief Accounting Officer · Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,066

F1 · shares: Shares withheld by the Issuer to satisfy applicable withholding taxes upon vesting of restricted stock units.

SEC source: 0001062993-23-004533 · form4.xml · nonDerivative · entry 1

Smeykal Megan · CIK 0001899973 · Chief Accounting Officer · Controller

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,489

F1 · shares: These restricted stock units will vest in four equal annual installments beginning on February 21, 2024, subject to the Reporting Person's continuous service through the applicable vesting dates.

SEC source: 0001493152-22-030666 · ownership.xml · nonDerivative · entry 2

Opaleye Management Inc. · CIK 0001595855 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Managed Account

Disclosed balance after: 124,813

F3 · price: This transaction was executed in multiple trades at prices ranging from $7.76 to $7.85; the price reported above reflects the weighted average purchase price. The reporting person undertakes to provide upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased.

F2 · ownership.nature: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account.

SEC source: 0001493152-22-030666 · ownership.xml · nonDerivative · entry 1

Opaleye Management Inc. · CIK 0001595855 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Opaleye, L.P.

Disclosed balance after: 1,948,000

F3 · price: This transaction was executed in multiple trades at prices ranging from $7.76 to $7.85; the price reported above reflects the weighted average purchase price. The reporting person undertakes to provide upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased.

F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund.

SEC source: 0001493152-22-028176 · ownership.xml · nonDerivative · entry 2

Opaleye Management Inc. · CIK 0001595855 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Managed Account

Disclosed balance after: 123,551

F2 · ownership.nature: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account.

SEC source: 0001493152-22-028176 · ownership.xml · nonDerivative · entry 1

Opaleye Management Inc. · CIK 0001595855 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Opaleye, L.P.

Disclosed balance after: 1,929,000

F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund.

SEC source: 0001493152-22-026798 · ownership.xml · nonDerivative · entry 2

Opaleye Management Inc. · CIK 0001595855 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Managed Account

Disclosed balance after: 122,551

F3 · price: This transaction was executed in multiple trades at prices ranging from $7.9804 to $8.00; the price reported above reflects the weighted average purchase price. The reporting person undertakes to provide upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased.

F2 · ownership.nature: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account.

SEC source: 0001493152-22-026798 · ownership.xml · nonDerivative · entry 1

Opaleye Management Inc. · CIK 0001595855 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Opaleye, L.P.

Disclosed balance after: 1,914,000

F3 · price: This transaction was executed in multiple trades at prices ranging from $7.9804 to $8.00; the price reported above reflects the weighted average purchase price. The reporting person undertakes to provide upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased.

F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund.

SEC source: 0001493152-22-026276 · ownership.xml · nonDerivative · entry 2

Opaleye Management Inc. · CIK 0001595855 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Managed Account

Disclosed balance after: 122,247

F3 · price: This transaction was executed in multiple trades at prices ranging from $8.0873 to $8.09; the price reported above reflects the weighted average purchase price. The reporting person undertakes to provide upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased.

F2 · ownership.nature: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account.

SEC source: 0001493152-22-026276 · ownership.xml · nonDerivative · entry 1

Opaleye Management Inc. · CIK 0001595855 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Opaleye, L.P.

Disclosed balance after: 1,907,500

F3 · price: This transaction was executed in multiple trades at prices ranging from $8.0873 to $8.09; the price reported above reflects the weighted average purchase price. The reporting person undertakes to provide upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased.

F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund.

SEC source: 0001493152-22-026144 · ownership.xml · nonDerivative · entry 4

Opaleye Management Inc. · CIK 0001595855 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Managed Account

Disclosed balance after: 121,247

F3 · price: This transaction was executed in multiple trades at prices ranging from $8.0786 to $8.085; the price reported above reflects the weighted average purchase price. The reporting person undertakes to provide upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased.

F2 · ownership.nature: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account.

SEC source: 0001493152-22-026144 · ownership.xml · nonDerivative · entry 3

Opaleye Management Inc. · CIK 0001595855 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Opaleye, L.P.

Disclosed balance after: 1,890,500

F3 · price: This transaction was executed in multiple trades at prices ranging from $8.0786 to $8.085; the price reported above reflects the weighted average purchase price. The reporting person undertakes to provide upon request by the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares purchased.

F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund.

SEC source: 0001493152-22-026144 · ownership.xml · nonDerivative · entry 2

Opaleye Management Inc. · CIK 0001595855 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Managed Account

Disclosed balance after: 120,875

F2 · ownership.nature: Securities owned by a separately managed account (the "Managed Account"). As the portfolio manager of the Managed Account, Opaleye may be deemed to beneficially own the securities owned directly by the Managed Account.

SEC source: 0001493152-22-026144 · ownership.xml · nonDerivative · entry 1

Opaleye Management Inc. · CIK 0001595855 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Opaleye, L.P.

Disclosed balance after: 1,888,500

F1 · ownership.nature: Represents securities owned directly by Opaleye, L.P. (the "Fund"). As the investment manager of the Fund, Opaleye Management Inc. may be deemed to beneficially own the securities owned directly by the Fund.

SEC source: 0000899243-22-029273 · doc4.xml · nonDerivative · entry 1

EW HEALTHCARE PARTNERS FUND 2, L.P. · CIK 0001746777 · See footnote 2

EW HEALTHCARE PARTNERS FUND 2-A, L.P. · CIK 0001746779 · 10% owner · See footnote 2

EW Healthcare Partners Fund 2 GP, L.P. · CIK 0001793943 · 10% owner

EW Healthcare Partners Fund 2-UGP, LLC · CIK 0001793948 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 4,105,709

F1 · ownership.nature: The share total shown above is the aggregate amount of shares purchased by EW Healthcare Partners Fund 2, L.P. ("Fund 2") and EW Healthcare Partners Fund 2-A, L.P. ("Fund 2-A") on the date set forth above. Fund 2 purchased 196,483 shares of the amount shown above and Fund 2-A purchased 303,517 shares of the amount shown above. Fund 2 now holds a total of 1,630,994 shares and Fund 2-A now holds a total of 2,474,715 shares of the Issuer.

F2 · ownership.nature: EW Healthcare Partners Fund 2 GP, L.P. (the "EW Funds GP"), is the general partner of each of EW Healthcare Partners Fund 2, L.P . ("Fund 2") and EW Healthcare Partners Fund 2-A, L.P. (''EW Fund 2-A" and together with EW Fund 2, the ''EW Funds"). EW Healthcare Partners Fund 2- UGP, LLC (the "General Partner") is the general partner of EW Funds GP. The General Partner holds sole voting and dispositive power over the shares held by each of the EW Funds (the "Shares''). The managers of the General Partner are Martin P. Sutter, Ron Eastman, Scott Barry and Petri Vainio (collectively, the ''Managers'') and may exercise voting and investment control over the Shares only by majority action of the Managers. Each individual Manager, the EW Funds GP and the General Partner disclaims ownership over the Shares except to the extent of his or its respective pecuniary interest therein.