TAK

SEC source: 0001395064-26-000340 · wk-form4_1789521164.xml · nonDerivative · entry 1

Duprey Lauren Rusckowski · CIK 0001977746 · Chief Transformation Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 191,522

SEC source: 0001395064-26-000335 · wk-form4_1788486556.xml · nonDerivative · entry 1

Plump Andrew Stewart · CIK 0001977689 · Director · President, R&D

10b5-1 filing: Plan reported

Ownership: Indirect · By Trust

Disclosed balance after: 145,465

F1 · kind: The sales reported herein were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on May 15, 2026.

SEC source: 0001493152-26-039693 · ownership.xml · nonDerivative · entry 1

Plump Andrew Stewart · CIK 0001977689 · Director · President, R&D

10b5-1 filing: Plan reported

Ownership: Indirect · By Trust

Disclosed balance after: 261,656

F1 · kind: The sales reported herein were effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on May 15, 2026.

SEC source: 0001493152-26-039214 · ownership.xml · nonDerivative · entry 1

Greenway Nicola Deidre Petal · CIK 0002123546 · Chief Human Resources Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,049

SEC source: 0001493152-26-037352 · ownership.xml · nonDerivative · entry 1

Shannon Elaine Mary · CIK 0002009368 · Pres., Global Supply & Quality

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,311

SEC source: 0001493152-26-037499 · ownership.xml · nonDerivative · entry 1

Shannon Elaine Mary · CIK 0002009368 · Pres., Global Supply & Quality

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 63,333

F1 · kind: Represents a mandatory sale to cover taxes associated with the vesting of equity awards held by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

F3 · balance_after: The total in Column 5 represents the amount of American Depositary Shares held by the Reporting Person as of the date of this filing.

SEC source: 0001493152-26-037515 · ownership.xml · nonDerivative · entry 1

Farajallah Awny Samaan Botros · CIK 0002121389 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 116,177

F1 · kind: Represents a mandatory sale to cover taxes associated with the vesting of equity awards held by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001493152-26-037514 · ownership.xml · nonDerivative · entry 1

Ibrahim Ramy Riad Ahmed · CIK 0002121395 · President, PDT BU

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 102,588

F1 · kind: Represents a mandatory sale to cover taxes associated with the vesting of equity awards held by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001493152-26-037513 · ownership.xml · nonDerivative · entry 1

Pacheco Rhonda Janice · CIK 0002111489 · President, U.S. Business Unit

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 182,507

F1 · kind: Represents a mandatory sale to cover taxes associated with the vesting of equity awards held by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001493152-26-037509 · ownership.xml · nonDerivative · entry 1

Duprey Lauren Rusckowski · CIK 0001977746 · Chief Transformation Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 226,057

F1 · kind: Represents a mandatory sale to cover taxes associated with the vesting of equity awards held by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001493152-26-037507 · ownership.xml · nonDerivative · entry 1

Plump Andrew Stewart · CIK 0001977689 · Director · President, R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 766,569

F1 · kind: Represents a mandatory sale to cover taxes associated with the vesting of equity awards held by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001493152-26-037505 · ownership.xml · nonDerivative · entry 1

Pignagnoli Agosti Marcello · CIK 0001977817 · Head, Strat. & Port. Dev

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 176,977

F1 · kind: Represents a mandatory sale to cover taxes associated with the vesting of equity awards held by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001493152-26-037502 · ownership.xml · nonDerivative · entry 1

Bitetti Teresa Marie · CIK 0001977608 · President, OBU

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 252,010

F1 · kind: Represents a mandatory sale to cover taxes associated with the vesting of equity awards held by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001493152-26-037494 · ownership.xml · nonDerivative · entry 1

Ricci Gabriele · CIK 0001977815 · Chief Data & Tech. Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 171,654

F1 · kind: Represents a mandatory sale to cover taxes associated with the vesting of equity awards held by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001493152-26-037486 · ownership.xml · nonDerivative · entry 1

Greenway Nicola Deidre Petal · CIK 0002123546 · Chief Human Resources Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,029

F1 · kind: Represents a mandatory sale to cover taxes associated with the vesting of equity awards held by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

F3 · balance_after: The total in Column 5 represents the amount of American Depositary Shares held by the Reporting Person as of the date of this filing.

SEC source: 0001493152-26-037484 · ownership.xml · nonDerivative · entry 1

Kim Julie So-Young · CIK 0001977732 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 391,489

F1 · kind: Represents a mandatory sale to cover taxes associated with the vesting of equity awards held by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001493152-26-037482 · ownership.xml · nonDerivative · entry 1

Platford Giles Richard · CIK 0001977620 · President, IBU

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 315,838

F1 · kind: Represents a mandatory sale to cover taxes associated with the vesting of equity awards held by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001493152-26-037480 · ownership.xml · nonDerivative · entry 1

Furney Natalie Anne Marie · CIK 0002111535 · Global General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 204,298

F1 · kind: Represents a mandatory sale to cover taxes associated with the vesting of equity awards held by the Reporting Person.

F2 · price: The price reported in Column 4 is a weighted average price. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001493152-26-037351 · ownership.xml · nonDerivative · entry 2

Greenway Nicola Deidre Petal · CIK 0002123546 · Chief Human Resources Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 59,803

SEC source: 0001493152-26-037351 · ownership.xml · nonDerivative · entry 1

Greenway Nicola Deidre Petal · CIK 0002123546 · Chief Human Resources Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 93,431

SEC source: 0001395064-26-000275 · wk-form4_1783376919.xml · derivative · entry 3

MARAGANORE JOHN · CIK 0001180432 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 1,152 shares

Expires 2026-06-01

F3 · derivative.exercise_price: Each Tax Obligation Award was the economic equivalent of one Ordinary Share that, upon vest, was converted into to a cash payment primarily to cover tax obligations. Any remaining proceeds from the disposition of the associated Ordinary Shares will be delivered to the reporting person on July 10.

F3 · date: Each Tax Obligation Award was the economic equivalent of one Ordinary Share that, upon vest, was converted into to a cash payment primarily to cover tax obligations. Any remaining proceeds from the disposition of the associated Ordinary Shares will be delivered to the reporting person on July 10.

F4 · price: The price reported in Column 8 is a weighted average price denominated in Yen. These shares were sold in transactions at prices ranging from JPY 4,883 to JPY 5,045, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001395064-26-000276 · wk-form4_1783376940.xml · derivative · entry 3

GILLIS STEVEN · CIK 0001229592 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 1,152 shares

Expires 2026-06-01

F3 · derivative.exercise_price: Each Tax Obligation Award was the economic equivalent of one Ordinary Share that, upon vest, was converted into to a cash payment primarily to cover tax obligations. Any remaining proceeds from the disposition of the associated Ordinary Shares will be delivered to the reporting person on July 10.

F3 · date: Each Tax Obligation Award was the economic equivalent of one Ordinary Share that, upon vest, was converted into to a cash payment primarily to cover tax obligations. Any remaining proceeds from the disposition of the associated Ordinary Shares will be delivered to the reporting person on July 10.

F4 · price: The price reported in Column 8 is a weighted average price denominated in Yen. These shares were sold in transactions at prices ranging from JPY 4,883 to JPY 5,045, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001395064-26-000274 · wk-form4_1783376900.xml · derivative · entry 3

Reed Kimberly A. · CIK 0001873931 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 1,152 shares

Expires 2026-06-01

F3 · derivative.exercise_price: Each Tax Obligation Award was the economic equivalent of one Ordinary Share that, upon vest, was converted into to a cash payment primarily to cover tax obligations. Any remaining proceeds from the disposition of the associated Ordinary Shares will be delivered to the reporting person on July 10.

F3 · date: Each Tax Obligation Award was the economic equivalent of one Ordinary Share that, upon vest, was converted into to a cash payment primarily to cover tax obligations. Any remaining proceeds from the disposition of the associated Ordinary Shares will be delivered to the reporting person on July 10.

F4 · price: The price reported in Column 8 is a weighted average price denominated in Yen. These shares were sold in transactions at prices ranging from JPY 4,883 to JPY 5,045, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001395064-26-000270 · wk-form4_1783376039.xml · derivative · entry 2

Iijima Masami · CIK 0002114485 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 2,152 shares

Expires 2026-06-01

F2 · derivative.exercise_price: Each Tax Obligation Award was the economic equivalent of one Ordinary Share that, upon vest, was converted into to a cash payment primarily to cover tax obligations. Any remaining proceeds from the disposition of the associated Ordinary Shares will be delivered to the reporting person on July 10.

F2 · date: Each Tax Obligation Award was the economic equivalent of one Ordinary Share that, upon vest, was converted into to a cash payment primarily to cover tax obligations. Any remaining proceeds from the disposition of the associated Ordinary Shares will be delivered to the reporting person on July 10.

F3 · price: The price reported in Column 8 is a weighted average price denominated in Yen. These shares were sold in transactions at prices ranging from JPY 4,883 to JPY 5,045, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001395064-26-000263 · wk-form4_1783375803.xml · derivative · entry 2

Tsusaka Miki · CIK 0002113695 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 2,152 shares

Expires 2026-06-01

F2 · derivative.exercise_price: Each Tax Obligation Award was the economic equivalent of one Ordinary Share that, upon vest, was converted into to a cash payment primarily to cover tax obligations. Any remaining proceeds from the disposition of the associated Ordinary Shares will be delivered to the reporting person on July 10.

F2 · date: Each Tax Obligation Award was the economic equivalent of one Ordinary Share that, upon vest, was converted into to a cash payment primarily to cover tax obligations. Any remaining proceeds from the disposition of the associated Ordinary Shares will be delivered to the reporting person on July 10.

F3 · price: The price reported in Column 8 is a weighted average price denominated in Yen. These shares were sold in transactions at prices ranging from JPY 4,883 to JPY 5,045, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001395064-26-000261 · wk-form4_1783375765.xml · derivative · entry 2

Miyabashira Asuka · CIK 0002111457 · President, Japan Pharma B.U.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 1,022 shares

Expires 2026-06-01

F2 · derivative.exercise_price: Each Tax Obligation Award was the economic equivalent of one Ordinary Share that, upon vest, was converted into to a cash payment primarily to cover tax obligations. Any remaining proceeds from the disposition of the associated Ordinary Shares will be delivered to the reporting person on July 10.

F2 · date: Each Tax Obligation Award was the economic equivalent of one Ordinary Share that, upon vest, was converted into to a cash payment primarily to cover tax obligations. Any remaining proceeds from the disposition of the associated Ordinary Shares will be delivered to the reporting person on July 10.

F3 · price: The price reported in Column 8 is a weighted average price denominated in Yen. These shares were sold in transactions at prices ranging from JPY 4,882 to JPY 5,050, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001395064-26-000260 · wk-form4_1783375740.xml · derivative · entry 2

Furuta Milano · CIK 0002111400 · Director · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 16,619 shares

Expires 2026-06-01

F2 · derivative.exercise_price: Each Tax Obligation Award was the economic equivalent of one Ordinary Share that, upon vest, was converted into to a cash payment primarily to cover tax obligations. Any remaining proceeds from the disposition of the associated Ordinary Shares will be delivered to the reporting person on July 10.

F2 · date: Each Tax Obligation Award was the economic equivalent of one Ordinary Share that, upon vest, was converted into to a cash payment primarily to cover tax obligations. Any remaining proceeds from the disposition of the associated Ordinary Shares will be delivered to the reporting person on July 10.

F3 · price: The price reported in Column 8 is a weighted average price denominated in Yen. These shares were sold in transactions at prices ranging from JPY 4,882 to JPY 5,050, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001395064-26-000249 · wk-form4_1783375422.xml · nonDerivative · entry 1

Shannon Elaine Mary · CIK 0002009368 · Pres., Global Supply & Quality

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 87,674

F1 · kind: Represents an award of restricted stock units (RSUs). Each RSU represents a contingent right to receive one American Depositary Share. The RSUs vest in three equal annual installments beginning on July 1, 2027.

SEC source: 0001395064-26-000275 · wk-form4_1783376919.xml · derivative · entry 4

MARAGANORE JOHN · CIK 0001180432 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,319

Underlying: Ordinary Shares · 1,319 shares

Expires 2029-06-01

F5 · derivative.exercise_price: Each Tax Obligation Award is the economic equivalent of one Ordinary Share that, upon vest, will be converted to a cash payment primarily to cover tax obligations at the then-current market price of the Ordinary Shares.

SEC source: 0001395064-26-000275 · wk-form4_1783376919.xml · nonDerivative · entry 1

MARAGANORE JOHN · CIK 0001180432 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,400

F1 · kind: Represents an award of restricted stock units (RSU). Each RSU represents a contingent right to receive one Ordinary Share, which will be converted into an equivalent number of American Depositary Shares following vest. The RSUs vest on June 1, 2029.

F2 · balance_after: Reflects the conversion of 3,100 Ordinary Shares into 6,200 American Depositary Shares upon vesting of RSUs.

SEC source: 0001395064-26-000276 · wk-form4_1783376940.xml · derivative · entry 4

GILLIS STEVEN · CIK 0001229592 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,319

Underlying: Ordinary Shares · 1,319 shares

Expires 2029-06-01

F5 · derivative.exercise_price: Each Tax Obligation Award is the economic equivalent of one Ordinary Share that, upon vest, will be converted to a cash payment primarily to cover tax obligations at the then-current market price of the Ordinary Shares.

SEC source: 0001395064-26-000276 · wk-form4_1783376940.xml · nonDerivative · entry 1

GILLIS STEVEN · CIK 0001229592 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,400

F1 · kind: Represents an award of restricted stock units (RSU). Each RSU represents a contingent right to receive one Ordinary Share, which will be converted into an equivalent number of American Depositary Shares following vest. The RSUs vest on June 1, 2029.

F2 · balance_after: Reflects the conversion of 3,100 Ordinary Shares into 6,200 American Depositary Shares upon vesting of RSUs.

SEC source: 0001395064-26-000268 · wk-form4_1783375918.xml · derivative · entry 2

BROUSSARD BRUCE D · CIK 0001185643 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,319

Underlying: Ordinary Shares · 1,319 shares

Expires 2029-06-01

F2 · derivative.exercise_price: Each Tax Obligation Award is the economic equivalent of one Ordinary Share that, upon vest, will be converted to a cash payment primarily to cover tax obligations at the then-current market price of the Ordinary Shares.

SEC source: 0001395064-26-000268 · wk-form4_1783375918.xml · nonDerivative · entry 1

BROUSSARD BRUCE D · CIK 0001185643 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,595

F1 · kind: Represents an award of restricted stock units (RSU). Each RSU represents a contingent right to receive one Ordinary Share, which will be converted into an equivalent number of American Depositary Shares following vest. The RSUs vest on June 1, 2029.

SEC source: 0001395064-26-000274 · wk-form4_1783376900.xml · derivative · entry 4

Reed Kimberly A. · CIK 0001873931 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,319

Underlying: Ordinary Shares · 1,319 shares

Expires 2029-06-01

F5 · derivative.exercise_price: Each Tax Obligation Award is the economic equivalent of one Ordinary Share that, upon vest, will be converted to a cash payment primarily to cover tax obligations at the then-current market price of the Ordinary Shares.

SEC source: 0001395064-26-000274 · wk-form4_1783376900.xml · nonDerivative · entry 1

Reed Kimberly A. · CIK 0001873931 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,400

F1 · kind: Represents an award of restricted stock units (RSU). Each RSU represents a contingent right to receive one Ordinary Share, which will be converted into an equivalent number of American Depositary Shares following vest. The RSUs vest on June 1, 2029.

F2 · balance_after: Reflects the conversion of 3,100 Ordinary Shares into 6,200 American Depositary Shares upon vesting of RSUs.

SEC source: 0001395064-26-000270 · wk-form4_1783376039.xml · derivative · entry 3

Iijima Masami · CIK 0002114485 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,937

Underlying: Ordinary Shares · 1,937 shares

Expires 2029-06-01

F4 · derivative.exercise_price: Each Tax Obligation Award is the economic equivalent of one Ordinary Share that, upon vest, will be converted to a cash payment primarily to cover tax obligations at the then-current market price of the Ordinary Shares.

SEC source: 0001395064-26-000270 · wk-form4_1783376039.xml · nonDerivative · entry 1

Iijima Masami · CIK 0002114485 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,601

F1 · kind: Represents an award of restricted stock units (RSUs). Each RSU represents a contingent right to receive one share of Common Stock. The RSUs vest on June 1, 2029.

SEC source: 0001395064-26-000266 · wk-form4_1783375873.xml · derivative · entry 2

Stoffels Paulus · CIK 0001559387 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,307

Underlying: Ordinary Shares · 1,307 shares

Expires 2029-06-01

F2 · derivative.exercise_price: Each Tax Obligation Award is the economic equivalent of one Ordinary Share that, upon vest, will be converted to a cash payment primarily to cover tax obligations at the then-current market price of the Ordinary Shares.

SEC source: 0001395064-26-000266 · wk-form4_1783375873.xml · nonDerivative · entry 1

Stoffels Paulus · CIK 0001559387 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,800

F1 · kind: Represents an award of restricted stock units (RSU). Each RSU represents a contingent right to receive one Ordinary Share, which will be converted into an equivalent number of American Depositary Shares following vest. The RSUs vest on June 1, 2029.

SEC source: 0001395064-26-000264 · wk-form4_1783375832.xml · derivative · entry 2

Kimura Koichiro · CIK 0002137620 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,937

Underlying: Ordinary Shares · 1,937 shares

Expires 2029-06-01

F2 · derivative.exercise_price: Each Tax Obligation Award is the economic equivalent of one Ordinary Share that, upon vest, will be converted to a cash payment primarily to cover tax obligations at the then-current market price of the Ordinary Shares.

SEC source: 0001395064-26-000264 · wk-form4_1783375832.xml · nonDerivative · entry 1

Kimura Koichiro · CIK 0002137620 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,800

F1 · kind: Represents an award of restricted stock units (RSUs). Each RSU represents a contingent right to receive one share of Common Stock. The RSUs vest on June 1, 2029.

SEC source: 0001395064-26-000263 · wk-form4_1783375803.xml · derivative · entry 3

Tsusaka Miki · CIK 0002113695 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,937

Underlying: Ordinary Shares · 1,937 shares

Expires 2029-06-01

F4 · derivative.exercise_price: Each Tax Obligation Award is the economic equivalent of one Ordinary Share that, upon vest, will be converted to a cash payment primarily to cover tax obligations at the then-current market price of the Ordinary Shares.

SEC source: 0001395064-26-000263 · wk-form4_1783375803.xml · nonDerivative · entry 1

Tsusaka Miki · CIK 0002113695 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,200

F1 · kind: Represents an award of restricted stock units (RSUs). Each RSU represents a contingent right to receive one share of Common Stock. The RSUs vest on June 1, 2029.

SEC source: 0001395064-26-000261 · wk-form4_1783375765.xml · derivative · entry 5

Miyabashira Asuka · CIK 0002111457 · President, Japan Pharma B.U.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 666

Underlying: Ordinary Shares · 666 shares

Expires 2029-06-01

F4 · derivative.exercise_price: Each Tax Obligation Award is the economic equivalent of one Ordinary Share that, upon vest, will be converted to a cash payment primarily to cover tax obligations at the then-current market price of the Ordinary Shares.

SEC source: 0001395064-26-000261 · wk-form4_1783375765.xml · derivative · entry 4

Miyabashira Asuka · CIK 0002111457 · President, Japan Pharma B.U.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,174

Underlying: Ordinary Shares · 664 shares

Expires 2028-06-01

F4 · derivative.exercise_price: Each Tax Obligation Award is the economic equivalent of one Ordinary Share that, upon vest, will be converted to a cash payment primarily to cover tax obligations at the then-current market price of the Ordinary Shares.

SEC source: 0001395064-26-000261 · wk-form4_1783375765.xml · derivative · entry 3

Miyabashira Asuka · CIK 0002111457 · President, Japan Pharma B.U.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,392

Underlying: Ordinary Shares · 664 shares

Expires 2027-06-01

F4 · derivative.exercise_price: Each Tax Obligation Award is the economic equivalent of one Ordinary Share that, upon vest, will be converted to a cash payment primarily to cover tax obligations at the then-current market price of the Ordinary Shares.

SEC source: 0001395064-26-000261 · wk-form4_1783375765.xml · nonDerivative · entry 1

Miyabashira Asuka · CIK 0002111457 · President, Japan Pharma B.U.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,500

F1 · kind: Represents an award of restricted stock units (RSUs). Each RSU represents a contingent right to receive one share of Common Stock. The RSUs vest in three equal annual installments beginning on June 1, 2027.

SEC source: 0001395064-26-000260 · wk-form4_1783375740.xml · derivative · entry 5

Furuta Milano · CIK 0002111400 · Director · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,288

Underlying: Ordinary Shares · 4,288 shares

Expires 2029-06-01

F4 · derivative.exercise_price: Each Tax Obligation Award is the economic equivalent of one Ordinary Share that, upon vest, will be converted to a cash payment primarily to cover tax obligations at the then-current market price of the Ordinary Shares.

SEC source: 0001395064-26-000260 · wk-form4_1783375740.xml · derivative · entry 4

Furuta Milano · CIK 0002111400 · Director · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,482

Underlying: Ordinary Shares · 4,288 shares

Expires 2028-06-01

F4 · derivative.exercise_price: Each Tax Obligation Award is the economic equivalent of one Ordinary Share that, upon vest, will be converted to a cash payment primarily to cover tax obligations at the then-current market price of the Ordinary Shares.