SRRK

SEC source: 0000899243-22-023965 · doc4.xml · nonDerivative · entry 2

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 206,897

F1 · price: The securities were purchased at a combined public offering price of $4.90 per share of common stock, and such combined offering price included accompanying Common Warrants.

F4 · ownership.nature: The securities are owned directly by Polaris Venture Partners Founders' Fund VI, L.P. ("PVPFF VI"). PVM VI is the general partner of PVPFF VI. PVM VI may be deemed to have sole voting and dispositive power with respect to the shares held by PVPFF VI and each of the Reporting Person and the other Managing Members may be deemed to have shared voting and dispositive power with respect to the shares held by PVPFF VI. Each of the Reporting Person, PVM VI and the other Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person, PVM VI or any of the other Managing Members is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-22-023965 · doc4.xml · nonDerivative · entry 1

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 3,540,530

F1 · price: The securities were purchased at a combined public offering price of $4.90 per share of common stock, and such combined offering price included accompanying Common Warrants.

F2 · ownership.nature: The securities are owned directly by Polaris Venture Partners VI, L.P. ("PVP VI"). Polaris Venture Management Co. VI, L.L.C. ("PVM VI") is the general partner of PVP VI and PVM VI is managed by its managing members, one of whom is the Reporting Person and a member of the Issuer's Board of Directors (collectively, the "Managing Members"). PVM VI may be deemed to have sole voting and dispositive power with respect to the shares held by PVP VI and each of the Reporting Person and the other Managing Members may be deemed to have shared voting and dispositive power with respect to the shares held by PVP VI.

F3 · ownership.nature: (Continued from Footnote 2) Each of the Reporting Person, PVM VI and the other Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person, PVM VI or any of the other Managing Members is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0001104659-22-073037 · tm2218901-7_4seq1.xml · derivative · entry 2

Parlavecchio Caryn · CIK 0001922346 · CHRO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,750

Underlying: Common Stock · 35,750 shares

Expires 2032-06-16

F3 · derivative.exercise_date: Options shall vest and become exercisable in twelve quarterly installments over three years, with the first quarterly installment to vest on September 16, 2022 and each additional installment to vest quarterly thereafter, provided the individual continues to have a service relationship with the Company on such vesting date.

SEC source: 0001104659-22-073037 · tm2218901-7_4seq1.xml · nonDerivative · entry 1

Parlavecchio Caryn · CIK 0001922346 · CHRO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,050

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in three annual installments over three years, with the first annual installment to vest on June 15, 2023 and each additional installment to vest annually thereafter; provided the individual continues to have a service relationship with the Company on such vesting date.

F2 · balance_after: Consists of 80,050 RSUs.

SEC source: 0001104659-22-073024 · tm2218901-1_4seq1.xml · derivative · entry 2

Carven Gregory John · CIK 0001815432 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,500

Underlying: Common Stock · 45,500 shares

Expires 2032-06-16

F3 · derivative.exercise_date: Options shall vest and become exercisable in twelve quarterly installments over three years, with the first quarterly installment to vest on September 16, 2022 and each additional installment to vest quarterly thereafter, provided the individual continues to have a service relationship with the Company on such vesting date.

SEC source: 0001104659-22-073024 · tm2218901-1_4seq1.xml · nonDerivative · entry 1

Carven Gregory John · CIK 0001815432 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 128,208

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in three annual installments over three years, with the first annual installment to vest on June 15, 2023 and each additional installment to vest annually thereafter; provided the individual continues to have a service relationship with the Company on such vesting date.

F2 · balance_after: Consists of 38,258 shares of common stock and 89,950 RSUs.

SEC source: 0001104659-22-073038 · tm2218901-8_4seq1.xml · derivative · entry 1

Vaishnaw Akshay · CIK 0001458494 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,000

Underlying: Common Stock · 14,000 shares

Expires 2032-06-16

F1 · derivative.exercise_date: This option shall vest and become fully exercisable on the first anniversary following the date of grant subject to continued service to the Issuer through such date.

SEC source: 0001104659-22-073036 · tm2218901-6_4seq1.xml · derivative · entry 2

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 74,750

Underlying: Common Stock · 74,750 shares

Expires 2032-06-16

F3 · derivative.exercise_date: Options shall vest and become exercisable in twelve quarterly installments over three years, with the first quarterly installment to vest on September 16, 2022 and each additional installment to vest quarterly thereafter, provided the individual continues to have a service relationship with the Company on such vesting date.

SEC source: 0001104659-22-073036 · tm2218901-6_4seq1.xml · nonDerivative · entry 1

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 154,222

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in three annual installments over three years, with the first annual installment to vest on June 15, 2023 and each additional installment to vest annually thereafter; provided the individual continues to have a service relationship with the Company on such vesting date.

F2 · balance_after: Consists of 3,859 shares of common stock and 150,363 RSUs.

SEC source: 0001104659-22-073034 · tm2218901-5_4seq1.xml · derivative · entry 2

Mahanthappa Nagesh K. · CIK 0001740430 · Interim CEO and President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2032-06-16

F3 · derivative.exercise_date: Options shall vest and become exercisable in four quarterly installments over one year, with the first quarterly installment to vest on September 16, 2022 and each additional installment to vest quarterly thereafter, provided the individual continues to have a service relationship with the Company on such vesting date.

SEC source: 0001104659-22-073034 · tm2218901-5_4seq1.xml · nonDerivative · entry 1

Mahanthappa Nagesh K. · CIK 0001740430 · Interim CEO and President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 480,491

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in their entirety on June 15, 2023; provided the reporting person continues to have a service relationship with the Company on such vesting date.

F2 · balance_after: Consists of 100,000 RSUs and 380,491 shares owned directly by Mahanthappa - Talland Revocable Trust, for which the reporting person's spouse, Valentine Talland, and reporting person are co-trustees.

SEC source: 0001104659-22-073026 · tm2218901-2_4seq1.xml · derivative · entry 1

Gilman Michael · CIK 0001291144 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,000

Underlying: Common Stock · 14,000 shares

Expires 2032-06-16

F1 · derivative.exercise_date: This option shall vest and become fully exercisable on the first anniversary following the date of grant subject to continued service to the Issuer through such date.

SEC source: 0001104659-22-073032 · tm2218901-4_4seq1.xml · derivative · entry 2

Ho Junlin · CIK 0001868114 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,500

Underlying: Common Stock · 45,500 shares

Expires 2032-06-16

F3 · derivative.exercise_date: Options shall vest and become exercisable in twelve quarterly installments over three years, with the first quarterly installment to vest on September 16, 2022 and each additional installment to vest quarterly thereafter, provided the individual continues to have a service relationship with the Company on such vesting date.

SEC source: 0001104659-22-073032 · tm2218901-4_4seq1.xml · nonDerivative · entry 1

Ho Junlin · CIK 0001868114 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 120,591

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in three annual installments over three years, with the first annual installment to vest on June 15, 2023 and each additional installment to vest annually thereafter; provided the individual continues to have a service relationship with the Company on such vesting date.

F2 · balance_after: Consists of 28,928 shares of common stock and 91,663 RSUs.

SEC source: 0001104659-22-073027 · tm2218901-3_4seq1.xml · derivative · entry 1

Hallal David · CIK 0001457477 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,000

Underlying: Common Stock · 14,000 shares

Expires 2032-06-16

F1 · derivative.exercise_date: This option shall vest and become fully exercisable on the first anniversary following the date of grant subject to continued service to the Issuer through such date.

SEC source: 0001104659-22-065955 · tm2216969-7_4seq1.xml · derivative · entry 1

Reed Joshua · CIK 0001746541 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,000

Underlying: Common Stock · 28,000 shares

Expires 2032-05-26

F1 · derivative.exercise_date: This option shall vest and become fully exercisable on the earlier of the first anniversary following the date of grant or the next scheduled Annual Meeting subject to continued service to the Issuer through such date.

SEC source: 0001104659-22-065958 · tm2216969-8_4seq1.xml · derivative · entry 1

Vaishnaw Akshay · CIK 0001458494 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,000

Underlying: Common Stock · 28,000 shares

Expires 2032-05-26

F1 · derivative.exercise_date: This option shall vest and become fully exercisable on the earlier of the first anniversary following the date of grant or the next scheduled Annual Meeting subject to continued service to the Issuer through such date.

SEC source: 0001104659-22-065954 · tm2216969-6_4seq1.xml · derivative · entry 1

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,000

Underlying: Common Stock · 28,000 shares

Expires 2032-05-26

F1 · derivative.exercise_date: This option shall vest and become fully exercisable on the earlier of the first anniversary following the date of grant or the next scheduled Annual Meeting subject to continued service to the Issuer through such date.

SEC source: 0001104659-22-065953 · tm2216969-5_4seq1.xml · derivative · entry 1

Hallal David · CIK 0001457477 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,000

Underlying: Common Stock · 28,000 shares

Expires 2032-05-26

F1 · derivative.exercise_date: This option shall vest and become fully exercisable on the earlier of the first anniversary following the date of grant or the next scheduled Annual Meeting subject to continued service to the Issuer through such date.

SEC source: 0001104659-22-065951 · tm2216969-4_4seq1.xml · derivative · entry 1

Gilman Michael · CIK 0001291144 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,000

Underlying: Common Stock · 28,000 shares

Expires 2032-05-26

F1 · derivative.exercise_date: This option shall vest and become fully exercisable on the earlier of the first anniversary following the date of grant or the next scheduled Annual Meeting subject to continued service to the Issuer through such date.

SEC source: 0001104659-22-065950 · tm2216969-3_4seq1.xml · derivative · entry 1

Burow Kristina · CIK 0001569248 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,000

Underlying: Common Stock · 28,000 shares

Expires 2032-05-26

F1 · derivative.exercise_date: This option shall vest and become fully exercisable on the earlier of the first anniversary following the date of grant or the next scheduled Annual Meeting subject to continued service to the Issuer through such date.

SEC source: 0001104659-22-065948 · tm2216969-2_4seq1.xml · derivative · entry 1

FLIER JEFFREY S. · CIK 0001740266 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,000

Underlying: Common Stock · 28,000 shares

Expires 2032-05-26

F1 · derivative.exercise_date: This option shall vest and become fully exercisable on the earlier of the first anniversary following the date of grant or the next scheduled Annual Meeting.

SEC source: 0001104659-22-023864 · tm226853-3_4seq1.xml · derivative · entry 2

Carven Gregory John · CIK 0001815432 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,000

Underlying: Common Stock · 35,000 shares

Expires 2032-02-14

F3 · derivative.exercise_date: Options vest and become exercisable in sixteen quarterly installments over four years. Vesting commenced on January 1, 2022 and the first vesting event shall occur three months thereafter; provided the reporting person continues to have a service relationship with the Company on such vesting date.

SEC source: 0001104659-22-023864 · tm226853-3_4seq1.xml · nonDerivative · entry 1

Carven Gregory John · CIK 0001815432 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 82,708

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on January 15, 2023 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Company on such vesting date.

F2 · balance_after: Consists of 38,258 shares of common stock and 44,450 RSUs.

SEC source: 0001104659-22-023866 · tm226853-5_4seq1.xml · derivative · entry 2

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 57,500

Underlying: Common Stock · 57,500 shares

Expires 2032-02-14

F3 · derivative.exercise_date: Options vest and become exercisable in sixteen quarterly installments over four years. Vesting commenced on January 1, 2022 and the first vesting event shall occur three months thereafter; provided the reporting person continues to have a service relationship with the Company on such vesting date.

SEC source: 0001104659-22-023866 · tm226853-5_4seq1.xml · nonDerivative · entry 1

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 79,472

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on January 15, 2023 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Company on such vesting date.

F2 · balance_after: Consists of 3,859 shares of common stock and 75,613 RSUs.

SEC source: 0001104659-22-023865 · tm226853-4_4seq1.xml · derivative · entry 2

Ho Junlin · CIK 0001868114 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,500

Underlying: Common Stock · 37,500 shares

Expires 2032-02-14

F3 · derivative.exercise_date: Options vest and become exercisable in sixteen quarterly installments over four years. Vesting commenced on January 1, 2022 and the first vesting event shall occur three months thereafter; provided the reporting person continues to have a service relationship with the Company on such vesting date.

SEC source: 0001104659-22-023865 · tm226853-4_4seq1.xml · nonDerivative · entry 1

Ho Junlin · CIK 0001868114 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,091

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on January 15, 2023 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Company on such vesting date.

F2 · balance_after: Consists of 28,928 shares of common stock and 46,163 RSUs.

SEC source: 0001104659-22-023863 · tm226853-2_4seq1.xml · derivative · entry 2

Mahanthappa Nagesh K. · CIK 0001740430 · Interim CEO and President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2032-02-14

F3 · derivative.exercise_date: Options shall vest in four quarterly installments over one year, with the first quarterly installment to vest on April 1, 2022 and each additional installment shall vest quarterly thereafter; provided the reporting person continues to have a service relationship with the Company on such vesting date.

SEC source: 0001104659-22-023863 · tm226853-2_4seq1.xml · nonDerivative · entry 1

Mahanthappa Nagesh K. · CIK 0001740430 · Interim CEO and President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,000

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in their entirety on January 15, 2023; provided the reporting person continues to have a service relationship with the Company on such vesting date.

F2 · balance_after: Consists of 50,000 RSUs.

SEC source: 0001104659-22-023861 · tm226853-1_4seq1.xml · derivative · entry 2

CHYUNG YUNG H. · CIK 0001740377 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,500

Underlying: Common Stock · 37,500 shares

Expires 2032-02-14

F3 · derivative.exercise_date: Options vest and become exercisable in sixteen quarterly installments over four years. Vesting commenced on January 1, 2022 and the first vesting event shall occur three months thereafter; provided the reporting person continues to have a service relationship with the Company on such vesting date.

SEC source: 0001104659-22-023861 · tm226853-1_4seq1.xml · nonDerivative · entry 1

CHYUNG YUNG H. · CIK 0001740377 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 258,496

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on January 15, 2023 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Company on such vesting date.

F2 · balance_after: Consists of 209,183 shares of common stock and 49,313 RSUs.

SEC source: 0001104659-22-005565 · tm223899-1_4seq1.xml · nonDerivative · entry 1

Carven Gregory John · CIK 0001815432 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,708

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on January 15, 2022. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to an award that was granted on February 1, 2021. Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU award vest annually over four years, subject to a continued service relationship with the Issuer on such vesting date.

F2 · price: The price reported above represents the weighted average selling price, as the transaction was executed in multiple trades. The reporting person hereby undertakes to provide full information regarding the number of shares and prices at which the transactions were effected to the SEC staff upon request.

F3 · balance_after: Consists of 38,258 shares of common stock and 9,450 RSUs.

SEC source: 0001104659-22-005567 · tm223899-3_4seq1.xml · nonDerivative · entry 1

Myles Edward H · CIK 0001358219 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,972

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on January 15, 2022. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to an award that was granted on February 1, 2021. Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU award vest annually over four years, subject to a continued service relationship with the Issuer on such vesting date.

F2 · price: This price reported above represents the weighted average selling price, as the transaction was executed in multiple trades . The reporting person hereby undertakes to provide full information regarding the number of shares and prices at which the transactions were effected to the SEC staff upon request.

F3 · balance_after: Consists of 3,859 shares of common stock and 18,113 RSUs.

SEC source: 0001104659-22-005568 · tm223899-4_4seq1.xml · nonDerivative · entry 1

Ho Junlin · CIK 0001868114 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,591

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on January 15, 2022. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to an award that was granted on February 1, 2021. Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU award vest annually over four years, subject to a continued service relationship with the Issuer on such vesting date.

F2 · price: The price reported above represents the weighted average selling price, as the transaction was executed in multiple trades. The reporting person hereby undertakes to provide full information regarding the number of shares and prices at which the transactions were effected to the SEC staff upon request.

F3 · balance_after: Consists of 28,928 shares of common stock and 8,663 RSUs.

SEC source: 0001104659-22-005566 · tm223899-2_4seq1.xml · nonDerivative · entry 1

CHYUNG YUNG H. · CIK 0001740377 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 220,996

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on January 15, 2022. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to an award that was granted on February 1, 2021. Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU award vest annually over four years, subject to a continued service relationship with the Issuer on such vesting date.

F2 · price: The price reported above represents the weighted average selling price, as the transaction was executed in multiple trades. The reporting person hereby undertakes to provide full information regarding the number of shares and prices at which the transactions were effected to the SEC staff upon request.

F3 · balance_after: Consists of 209,183 shares of common stock and 11,813 RSUs.

SEC source: 0000899243-21-045401 · doc4.xml · nonDerivative · entry 9

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,441

F6 · kind: Represents a change in the form of ownership of the Reporting Person by virtue of the receipt of shares as a result of the in-kind distribution of common stock of the Issuer for no consideration by PVM VI.

SEC source: 0000899243-21-045401 · doc4.xml · nonDerivative · entry 8

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 0

F5 · kind: Represents a distribution, and not a purchase or sale, without additional consideration by PVM VI to its members.

F4 · ownership.nature: The reportable securities are owned directly by PVM VI. PVM VI is the general partner of PVP VI and PVM VI is managed by the Managing Members. The Managing Members, one of whom is the Reporting Person who is a member of the Issuer's Board of Directors, may be deemed to have sole voting and dispositive power with respect to the shares held by PVM VI. Each of the Reporting Person and the other Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person or any of the other Managing Members is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-21-045401 · doc4.xml · nonDerivative · entry 7

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 160

F11 · kind: Represents a change in the form of ownership of PVM VI by virtue of the receipt of shares as a result of the in-kind distribution of common stock of the Issuer for no consideration by PVPFF VI.

F4 · ownership.nature: The reportable securities are owned directly by PVM VI. PVM VI is the general partner of PVP VI and PVM VI is managed by the Managing Members. The Managing Members, one of whom is the Reporting Person who is a member of the Issuer's Board of Directors, may be deemed to have sole voting and dispositive power with respect to the shares held by PVM VI. Each of the Reporting Person and the other Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person or any of the other Managing Members is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-21-045401 · doc4.xml · nonDerivative · entry 6

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 182

F9 · kind: Represents a change in the form of ownership of the Reporting Person by virtue of the receipt of shares as a result of the in-kind distribution of common stock of the Issuer for no consideration by PVPFF VI.

F10 · ownership.nature: The reportable securities are owned by North Star Profit Sharing Trust for the benefit of the Reporting Person.

SEC source: 0000899243-21-045401 · doc4.xml · nonDerivative · entry 5

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 140,755

F7 · kind: Represents a distribution, and not a purchase or sale, without additional consideration by Polaris Venture Partners Founders' Fund VI, L.P. ("PVPFF VI") to its partners.

F8 · ownership.nature: The reportable securities are owned directly by PVPFF VI. PVM VI is the general partner of PVPFF VI. PVM VI may be deemed to have sole voting and dispositive power with respect to the shares held by PVPFF VI and each of the Reporting Person and the other Managing Members may be deemed to have shared voting and dispositive power with respect to the shares held by PVPFF VI. Each of the Reporting Person, PVM VI and the other Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person, PVM VI or any of the other Managing Members is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-21-045401 · doc4.xml · nonDerivative · entry 4

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,420

F6 · kind: Represents a change in the form of ownership of the Reporting Person by virtue of the receipt of shares as a result of the in-kind distribution of common stock of the Issuer for no consideration by PVM VI.

SEC source: 0000899243-21-045401 · doc4.xml · nonDerivative · entry 3

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 0

F5 · kind: Represents a distribution, and not a purchase or sale, without additional consideration by PVM VI to its members.

F4 · ownership.nature: The reportable securities are owned directly by PVM VI. PVM VI is the general partner of PVP VI and PVM VI is managed by the Managing Members. The Managing Members, one of whom is the Reporting Person who is a member of the Issuer's Board of Directors, may be deemed to have sole voting and dispositive power with respect to the shares held by PVM VI. Each of the Reporting Person and the other Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person or any of the other Managing Members is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-21-045401 · doc4.xml · nonDerivative · entry 2

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 55,667

F3 · kind: Represents a change in the form of ownership of PVM VI by virtue of the receipt of shares in the in-kind distribution of common stock of the Issuer for no consideration by PVP VI.

F4 · ownership.nature: The reportable securities are owned directly by PVM VI. PVM VI is the general partner of PVP VI and PVM VI is managed by the Managing Members. The Managing Members, one of whom is the Reporting Person who is a member of the Issuer's Board of Directors, may be deemed to have sole voting and dispositive power with respect to the shares held by PVM VI. Each of the Reporting Person and the other Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person or any of the other Managing Members is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-21-045401 · doc4.xml · nonDerivative · entry 1

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 2,408,680

F1 · kind: Represents a distribution, and not a purchase or sale, without additional consideration by Polaris Venture Partners VI, L.P. ("PVP VI") to its partners.

F2 · ownership.nature: The reportable securities are owned directly by PVP VI. Polaris Venture Management Co. VI, L.L.C. ("PVM VI") is the general partner of PVP VI and PVM VI is managed by its managing members, one of whom is the Reporting Person and a member of the Issuer's Board of Directors (collectively, the "Managing Members"). PVM VI may be deemed to have sole voting and dispositive power with respect to the shares held by PVP VI and each of the Reporting Person and the other Managing Members may be deemed to have shared voting and dispositive power with respect to the shares held by PVP VI. Each of the Reporting Person, PVM VI and the other Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person, PVM VI or any of the other Managing Members is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0001104659-21-139527 · tm2133015-1_4seq1.xml · derivative · entry 12

Myles Edward H · CIK 0001358219 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 187,500

Underlying: Common Stock · 4,879 shares

Expires 2030-07-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · derivative.exercise_date: Shares vest over four years, with 25% vesting on July 16, 2021, and the remainder of shares vesting in twelve (12) quarterly installments thereafter, subject to such individual's continued service relationship with the Issuer through each such date.

SEC source: 0001104659-21-139527 · tm2133015-1_4seq1.xml · nonDerivative · entry 6

Myles Edward H · CIK 0001358219 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,150

F1 · shares: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F11 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $35.00 to $35.16. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F3 · balance_after: Consists of 24,150 RSUs.

SEC source: 0001104659-21-139527 · tm2133015-1_4seq1.xml · nonDerivative · entry 5

Myles Edward H · CIK 0001358219 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,029

F1 · shares: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F9 · price: The shares of common stock were acquired at a price per share of $13.83 as reported in Table II.

F10 · balance_after: Consists of 4,879 shares of common stock and 24,150 RSUs. Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU award will vest annually over four years, subject to a continued service relationship with the Issuer on such vesting date.

SEC source: 0001104659-21-139527 · tm2133015-1_4seq1.xml · derivative · entry 11

Myles Edward H · CIK 0001358219 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 192,379

Underlying: Common Stock · 2,351 shares

Expires 2030-07-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · derivative.exercise_date: Shares vest over four years, with 25% vesting on July 16, 2021, and the remainder of shares vesting in twelve (12) quarterly installments thereafter, subject to such individual's continued service relationship with the Issuer through each such date.

SEC source: 0001104659-21-139527 · tm2133015-1_4seq1.xml · derivative · entry 10

Myles Edward H · CIK 0001358219 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 194,730

Underlying: Common Stock · 47,497 shares

Expires 2030-07-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · derivative.exercise_date: Shares vest over four years, with 25% vesting on July 16, 2021, and the remainder of shares vesting in twelve (12) quarterly installments thereafter, subject to such individual's continued service relationship with the Issuer through each such date.