SRRK

SEC source: 0001104659-26-110976 · tm2626188-1_4seq1.xml · nonDerivative · entry 1

Woods Keith · CIK 0001996804 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 572,021

F1 · shares: On September 24, 2026, the reporting person transferred 48,034 shares of the Issuer's Common Stock to the RKW Irrevocable Trust for no consideration. The reporting person's spouse serves as trustee of the RKW Irrevocable Trust. The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose.

F2 · balance_after: Consists of 0 shares of common stock, 122,021 RSUs subject to time-based vesting conditions and 450,000 RSUs subject to performance- and time-based vesting conditions.

SEC source: 0001104659-26-110006 · tm2626025-1_4seq1.xml · nonDerivative · entry 1

Hallal David · CIK 0001457477 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,602,382

F1 · shares: On September 21, 2026, the reporting person transferred 36,652 shares of the Issuer's Common Stock to The Hallal Family Irrevocable Trust-2021 (the "Hallal 2021 Trust") for no consideration. The reporting person and his spouse serve as trustees of the Hallal 2021 Trust. The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose.

F2 · balance_after: Consists of 161,878 shares of common stock, 315,504 RSUs subject to time-based vesting conditions and 1,125,000 RSUs subject to performance- and time-based vesting conditions.

SEC source: 0001193125-26-296245 · ownership.xml · nonDerivative · entry 3

Peng Katie · CIK 0001983850 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 34,301

F1 · shares: This sale was effected pursuant to a Rule 10b-5-1 trading plan adopted on March 20, 2026 to cover tax obligations upon the vesting and settlement of restricted stock units (RSUs).

F6 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $54.860 to $55.016, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F7 · balance_after: Consists of 21,500 shares of common stock and 12,801 RSUs.

SEC source: 0001193125-26-296245 · ownership.xml · nonDerivative · entry 2

Peng Katie · CIK 0001983850 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 34,322

F1 · shares: This sale was effected pursuant to a Rule 10b-5-1 trading plan adopted on March 20, 2026 to cover tax obligations upon the vesting and settlement of restricted stock units (RSUs).

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $53.967 to $54.815, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F5 · balance_after: Consists of 21,521 shares of common stock and 12,801 RSUs.

SEC source: 0001193125-26-296245 · ownership.xml · nonDerivative · entry 1

Peng Katie · CIK 0001983850 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 36,759

F1 · shares: This sale was effected pursuant to a Rule 10b-5-1 trading plan adopted on March 20, 2026 to cover tax obligations upon the vesting and settlement of restricted stock units (RSUs).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $52.970 to $53.965, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F3 · balance_after: Consists of 23,958 shares of common stock and 12,801 RSUs.

SEC source: 0001193125-26-296247 · ownership.xml · nonDerivative · entry 2

Reed Joshua · CIK 0001746541 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 19,518

F1 · shares: This sale was effected pursuant to a Rule 10b-5-1 trading plan adopted on March 21, 2026 to cover tax obligations upon the vesting and settlement of restricted stock units (RSUs).

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $54.040 to $54.795, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F5 · balance_after: Consists of 12,679 shares of common stock and 6,839 RSUs.

SEC source: 0001193125-26-296247 · ownership.xml · nonDerivative · entry 1

Reed Joshua · CIK 0001746541 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,466

F1 · shares: This sale was effected pursuant to a Rule 10b-5-1 trading plan adopted on March 21, 2026 to cover tax obligations upon the vesting and settlement of restricted stock units (RSUs).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $53.050 to $54.030, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F3 · balance_after: Consists of 13,627 shares of common stock and 6,839 RSUs.

SEC source: 0001193125-26-296252 · ownership.xml · nonDerivative · entry 3

FLIER JEFFREY S. · CIK 0001740266 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 27,856

F1 · shares: This sale was effected pursuant to a Rule 10b-5-1 trading plan adopted on March 31, 2026 to cover tax obligations upon the vesting and settlement of restricted stock units (RSUs).

F6 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $54.805 to $55.010, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F7 · balance_after: Consists of 21,017 shares of common stock and 6,839 RSUs.

SEC source: 0001193125-26-296252 · ownership.xml · nonDerivative · entry 2

FLIER JEFFREY S. · CIK 0001740266 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 27,871

F1 · shares: This sale was effected pursuant to a Rule 10b-5-1 trading plan adopted on March 31, 2026 to cover tax obligations upon the vesting and settlement of restricted stock units (RSUs).

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $53.950 to $54.800, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F5 · balance_after: Consists of 21,032 shares of common stock and 6,839 RSUs.

SEC source: 0001193125-26-296252 · ownership.xml · nonDerivative · entry 1

FLIER JEFFREY S. · CIK 0001740266 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 29,341

F1 · shares: This sale was effected pursuant to a Rule 10b-5-1 trading plan adopted on March 31, 2026 to cover tax obligations upon the vesting and settlement of restricted stock units (RSUs).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $52.960 to $53.944, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F3 · balance_after: Consists of 22,502 shares of common stock and 6,839 RSUs.

SEC source: 0001193125-26-296251 · ownership.xml · nonDerivative · entry 3

Gilman Michael · CIK 0001291144 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 59,511

F1 · shares: This sale was effected pursuant to a Rule 10b-5-1 trading plan adopted on March 31, 2026 to cover tax obligations upon the vesting and settlement of restricted stock units (RSUs).

F6 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $54.790 to $55.010, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F7 · balance_after: Consists of 52,672 shares of common stock and 6,839 RSUs.

SEC source: 0001193125-26-296251 · ownership.xml · nonDerivative · entry 2

Gilman Michael · CIK 0001291144 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 59,554

F1 · shares: This sale was effected pursuant to a Rule 10b-5-1 trading plan adopted on March 31, 2026 to cover tax obligations upon the vesting and settlement of restricted stock units (RSUs).

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $53.960 to $54.750, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F5 · balance_after: Consists of 52,715 shares of common stock and 6,839 RSUs.

SEC source: 0001193125-26-296251 · ownership.xml · nonDerivative · entry 1

Gilman Michael · CIK 0001291144 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 60,709

F1 · shares: This sale was effected pursuant to a Rule 10b-5-1 trading plan adopted on March 31, 2026 to cover tax obligations upon the vesting and settlement of restricted stock units (RSUs).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $52.970 to $53.955, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F3 · balance_after: Consists of 53,870 shares of common stock and 6,839 RSUs.

SEC source: 0001193125-26-296248 · ownership.xml · nonDerivative · entry 2

Burow Kristina · CIK 0001569248 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 114,657

F1 · shares: This sale was effected pursuant to a Rule 10b-5-1 trading plan adopted on March 31, 2026 to cover tax obligations upon the vesting and settlement of restricted stock units (RSUs).

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $54.040 to $54.795, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F5 · balance_after: Consists of 107,818 shares of common stock and 6,839 RSUs.

SEC source: 0001193125-26-296248 · ownership.xml · nonDerivative · entry 1

Burow Kristina · CIK 0001569248 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 115,605

F1 · shares: This sale was effected pursuant to a Rule 10b-5-1 trading plan adopted on March 31, 2026 to cover tax obligations upon the vesting and settlement of restricted stock units (RSUs).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $53.050 to $54.030, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F3 · balance_after: Consists of 108,766 shares of common stock and 6,839 RSUs.

SEC source: 0001104659-26-071425 · tm2617049-2_4seq1.xml · derivative · entry 2

Peng Katie · CIK 0001983850 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,310

Underlying: Common Stock · 4,310 shares

Expires 2036-06-04

F3 · derivative.exercise_date: Options to vest and become fully exercisable on the earlier of the first anniversary following the date of grant or on the date of the Issuer's next Annual Meeting, subject to continued service to the Issuer through such date.

SEC source: 0001104659-26-071425 · tm2617049-2_4seq1.xml · nonDerivative · entry 1

Peng Katie · CIK 0001983850 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,747

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest on the earlier of June 15, 2027 or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

F2 · balance_after: Consists of 26,201 shares of common stock and 13,546 RSUs.

SEC source: 0001104659-26-071430 · tm2617049-6_4seq1.xml · derivative · entry 2

Reed Joshua · CIK 0001746541 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,310

Underlying: Common Stock · 4,310 shares

Expires 2036-06-04

F3 · derivative.exercise_date: Options to vest and become fully exercisable on the earlier of the first anniversary following the date of grant or on the date of the Issuer's next Annual Meeting, subject to continued service to the Issuer through such date.

SEC source: 0001104659-26-071430 · tm2617049-6_4seq1.xml · nonDerivative · entry 1

Reed Joshua · CIK 0001746541 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,571

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest on the earlier of June 15, 2027 or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

F2 · balance_after: Consists of 15,732 shares of common stock and 6,839 RSUs.

SEC source: 0001104659-26-071432 · tm2617049-7_4seq1.xml · derivative · entry 2

FLIER JEFFREY S. · CIK 0001740266 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,310

Underlying: Common Stock · 4,310 shares

Expires 2036-06-04

F3 · derivative.exercise_date: Options to vest and become fully exercisable on the earlier of the first anniversary following the date of grant or on the date of the Issuer's next Annual Meeting, subject to continued service to the Issuer through such date.

SEC source: 0001104659-26-071432 · tm2617049-7_4seq1.xml · nonDerivative · entry 1

FLIER JEFFREY S. · CIK 0001740266 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,909

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest on the earlier of June 15, 2027 or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

F2 · balance_after: Consists of 24,070 shares of common stock and 6,839 RSUs.

SEC source: 0001104659-26-071429 · tm2617049-5_4seq1.xml · derivative · entry 2

Brudnick Richard · CIK 0001692359 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,310

Underlying: Common Stock · 4,310 shares

Expires 2036-06-04

F3 · derivative.exercise_date: Options to vest and become fully exercisable on the earlier of the first anniversary following the date of grant or on the date of the Issuer's next Annual Meeting, subject to continued service to the Issuer through such date.

SEC source: 0001104659-26-071429 · tm2617049-5_4seq1.xml · nonDerivative · entry 1

Brudnick Richard · CIK 0001692359 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,896

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest on the earlier of June 15, 2027 or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

F2 · balance_after: Consists of 15,057 shares of common stock and 6,839 RSUs.

SEC source: 0001104659-26-071428 · tm2617049-4_4seq1.xml · derivative · entry 3

Burow Kristina · CIK 0001569248 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,310

Underlying: Common Stock · 4,310 shares

Expires 2036-06-04

F5 · derivative.exercise_date: Options to vest and become fully exercisable on the earlier of the first anniversary following the date of grant or on the date of the Issuer's next Annual Meeting, subject to continued service to the Issuer through such date.

SEC source: 0001104659-26-071428 · tm2617049-4_4seq1.xml · nonDerivative · entry 1

Burow Kristina · CIK 0001569248 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 117,710

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest on the earlier of June 15, 2027 or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

F2 · balance_after: Consists of 110,871 shares of common stock and 6,839 RSUs.

SEC source: 0001104659-26-071427 · tm2617049-3_4seq1.xml · derivative · entry 2

Gilman Michael · CIK 0001291144 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,310

Underlying: Common Stock · 4,310 shares

Expires 2036-06-04

F3 · derivative.exercise_date: Options to vest and become fully exercisable on the earlier of the first anniversary following the date of grant or on the date of the Issuer's next Annual Meeting, subject to continued service to the Issuer through such date.

SEC source: 0001104659-26-071427 · tm2617049-3_4seq1.xml · nonDerivative · entry 1

Gilman Michael · CIK 0001291144 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 62,055

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest on the earlier of June 15, 2027 or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

F2 · balance_after: Consists of 55,216 shares of common stock and 6,839 RSUs.

SEC source: 0001104659-26-071422 · tm2617049-1_4seq1.xml · derivative · entry 4

AKKARAJU SRINIVAS · CIK 0001253170 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,310

Underlying: Common Stock · 4,310 shares

Expires 2036-06-04

F5 · derivative.exercise_date: Options to vest and become fully exercisable on the earlier of the first anniversary following the date of grant or on the date of the Issuer's next Annual Meeting, subject to continued service to the Issuer through such date.

SEC source: 0001104659-26-071422 · tm2617049-1_4seq1.xml · nonDerivative · entry 1

AKKARAJU SRINIVAS · CIK 0001253170 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,971

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest on the earlier of June 15, 2027 or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

F2 · balance_after: Consists of 21,132 shares of common stock and 6,839 RSUs.

SEC source: 0001104659-26-048551 · tm2612694-1_4seq1.xml · derivative · entry 9

Burow Kristina · CIK 0001569248 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 18,000 shares

Expires 2034-06-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F10 · derivative.exercise_date: This stock option vested on May 22, 2025. No shares remain unvested under this stock option.

SEC source: 0001104659-26-048551 · tm2612694-1_4seq1.xml · derivative · entry 8

Burow Kristina · CIK 0001569248 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 36,000 shares

Expires 2033-06-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F9 · derivative.exercise_date: This stock option vested on June 21, 2024. No shares remain unvested under this stock option.

SEC source: 0001104659-26-048551 · tm2612694-1_4seq1.xml · derivative · entry 7

Burow Kristina · CIK 0001569248 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 28,000 shares

Expires 2032-05-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · derivative.exercise_date: This stock option vested on May 26, 2023. No shares remain unvested under this stock option.

SEC source: 0001104659-26-048551 · tm2612694-1_4seq1.xml · derivative · entry 6

Burow Kristina · CIK 0001569248 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 7,800 shares

Expires 2031-05-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · derivative.exercise_date: This stock option vested on May 26, 2022. No shares remain unvested under this stock option.

SEC source: 0001104659-26-048551 · tm2612694-1_4seq1.xml · nonDerivative · entry 4

Burow Kristina · CIK 0001569248 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 110,871

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · balance_after: Consists of 103,239 shares of common stock and 7,632 RSUs.

SEC source: 0001104659-26-048551 · tm2612694-1_4seq1.xml · nonDerivative · entry 3

Burow Kristina · CIK 0001569248 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 92,871

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · balance_after: Consists of 85,239 shares of common stock and 7,632 RSUs.

SEC source: 0001104659-26-048551 · tm2612694-1_4seq1.xml · nonDerivative · entry 2

Burow Kristina · CIK 0001569248 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 56,871

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · balance_after: Consists of 49,239 shares of common stock and 7,632 RSUs..

SEC source: 0001104659-26-048551 · tm2612694-1_4seq1.xml · nonDerivative · entry 1

Burow Kristina · CIK 0001569248 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,871

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Consists of 21,239 shares of common stock and 7,632 RSUs.

SEC source: 0001104659-26-045584 · tm2612274-4_4seq1.xml · nonDerivative · entry 1

Woods Keith · CIK 0001996804 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 620,055

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSUs") on April 15, 2026. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to awards that were granted on April 27, 2025. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards vest annually over four years, subject to a continued service relationship with the Issuer on the applicable vesting date.

F2 · balance_after: Consists of 48,034 shares of common stock, 122,021 RSUs subject to time-based vesting conditions and 450,000 RSUs subject to performance- and time-based vesting conditions.

SEC source: 0001104659-26-045583 · tm2612274-3_4seq1.xml · nonDerivative · entry 1

Vaishnaw Akshay · CIK 0001458494 · Director · President of R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 630,542

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSUs") on April 15, 2026. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to awards that were granted on April 27, 2025. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards vest annually over four years, subject to a continued service relationship with the Issuer on the applicable vesting date.

F2 · balance_after: Consists of 58,521 shares of common stock, 122,021 RSUs subject to time-based vesting conditions and 450,000 RSUs subject to performance- and time-based vesting conditions.

SEC source: 0001104659-26-045581 · tm2612274-1_4seq1.xml · nonDerivative · entry 1

Hallal David · CIK 0001457477 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,639,034

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSUs") on April 15, 2026. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to awards that were granted on April 27, 2025. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards vest annually over four years, subject to a continued service relationship with the Issuer on the applicable vesting date.

F2 · balance_after: Consists of 198,530 shares of common stock, 315,504 RSUs subject to time-based vesting conditions and 1,125,000 RSUs subject to performance- and time-based vesting conditions.

SEC source: 0001104659-26-045582 · tm2612274-2_4seq1.xml · nonDerivative · entry 1

Sinha Vikas · CIK 0001337845 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 619,856

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSUs") on April 15, 2026. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to awards that were granted on April 27, 2025. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards vest annually over four years, subject to a continued service relationship with the Issuer on the applicable vesting date.

F2 · balance_after: Consists of 47,835 shares of common stock, 122,021 RSUs subject to time-based vesting conditions and 450,000 RSUs subject to performance- and time-based vesting conditions.

SEC source: 0001104659-26-019789 · tm267344-1_4seq1.xml · nonDerivative · entry 3

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 98,445

F1 · shares: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F6 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $48.30 to $48.66, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F7 · balance_after: Consists of 98,445 RSUs.

SEC source: 0001104659-26-019789 · tm267344-1_4seq1.xml · nonDerivative · entry 2

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 98,645

F1 · shares: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $47.55 to $48.19, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F5 · balance_after: Consists of 200 shares of common stock and 98,445 RSUs.

SEC source: 0001104659-26-019789 · tm267344-1_4seq1.xml · nonDerivative · entry 1

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 99,502

F1 · shares: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $46.52 to $47.48, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F3 · balance_after: Consists of 1,057 shares of common stock and 98,445 RSUs.

SEC source: 0001922346-26-000004 · form4-02192026_040204.xml · nonDerivative · entry 1

Parlavecchio Caryn · CIK 0001922346 · CHRO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 169,087

F1 · shares: Represents the number of shares required to be sold by the Reporting Person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on February 15, 2026. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the Reporting Person. The shares vested pursuant to awards that were granted on February 13, 2023 and March 10, 2025. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards vest annually over four years, subject to a continued service relationship with the Issuer on the applicable vesting date.

F2 · balance_after: (2) Consists of 86,859 shares of common stock and 82,228 RSUs.

SEC source: 0001834528-26-000005 · form4-02192026_040209.xml · nonDerivative · entry 1

Marantz Jing L. · CIK 0001834528 · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 126,012

F1 · shares: Represents the number of shares required to be sold by the Reporting Person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on February 15, 2026. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the Reporting Person. The shares vested pursuant to awards that were granted on February 13, 2023 and March 10, 2025. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards vest annually over four years, subject to a continued service relationship with the Issuer on the applicable vesting date.

F2 · balance_after: Consists of 29,388 shares of common stock and 96,624 RSUs.

SEC source: 0001868114-26-000004 · form4-02192026_040206.xml · nonDerivative · entry 1

Ho Junlin · CIK 0001868114 · GENERAL COUNSEL

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 241,545

F1 · shares: Represents the number of shares required to be sold by the Reporting Person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on February 15, 2026. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the Reporting Person. The shares vested pursuant to awards that were granted on February 13, 2023 and March 10, 2025. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards vest annually over four years, subject to a continued service relationship with the Issuer on the applicable vesting date.

F2 · balance_after: Consists of 131,646 shares of common stock and 109,899 RSUs.

SEC source: 0001980298-26-000009 · form4-02192026_040201.xml · nonDerivative · entry 1

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 106,929

F1 · shares: Represents the number of shares required to be sold by the Reporting Person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on February 15, 2026. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the Reporting Person. The shares vested pursuant to awards that were granted on February 13, 2023 and March 10, 2025. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards vest annually over four years, subject to a continued service relationship with the Issuer on the applicable vesting date.

F2 · balance_after: Consists of 8,484 shares of common stock and 98,445 RSUs.

SEC source: 0001104659-26-013584 · tm266077-5_4seq1.xml · nonDerivative · entry 1

Parlavecchio Caryn · CIK 0001922346 · Chief Human Resources Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 178,122

F1 · shares: Represents restricted stock units ("RSUs") subject to time-based vesting conditions. Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on January 15, 2027 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on each such vesting date.

F2 · balance_after: Consists of 78,283 shares of common stock and 99,839 RSUs.

SEC source: 0001104659-26-013586 · tm266077-7_4seq1.xml · nonDerivative · entry 1

Sinha Vikas · CIK 0001337845 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 630,266

F1 · shares: Represents restricted stock units ("RSUs") subject to time-based vesting conditions. Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on January 15, 2027 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on each such vesting date.

F2 · balance_after: Consists of 33,245 shares of common stock, 147,021 RSUs subject to time-based vesting conditions and 450,000 RSUs subject to performance- and time-based vesting conditions.