SRRK

SEC source: 0000950170-23-065889 · ownership.xml · nonDerivative · entry 6

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 504

F9 · kind: Represents a change in the form of ownership of the Reporting Person by virtue of the receipt of shares as a result of the in-kind distribution of common stock of the Issuer for no consideration by PVPFF VI.

F10 · ownership.nature: The reportable securities are owned by North Star Profit Sharing Trust for the benefit of the Reporting Person.

SEC source: 0000950170-23-065889 · ownership.xml · nonDerivative · entry 5

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 179,291

F7 · kind: Represents a distribution, and not a purchase or sale, without additional consideration by Polaris Venture Partners Founders' Fund VI, L.P. ("PVPFF VI") to its partners.

F8 · ownership.nature: The reportable securities are owned directly by PVPFF VI. PVM VI is the general partner of PVPFF VI. PVM VI may be deemed to have sole voting and dispositive power with respect to the shares held by PVPFF VI and each of the Reporting Person and the other Managing Members may be deemed to have shared voting and dispositive power with respect to the shares held by PVPFF VI. Each of the Reporting Person, PVM VI and the other Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person, PVM VI or any of the other Managing Members is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000950170-23-065889 · ownership.xml · nonDerivative · entry 4

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,537

F6 · kind: Represents a change in the form of ownership of the Reporting Person by virtue of the receipt of shares as a result of the in-kind distribution of common stock of the Issuer for no consideration by PVM VI.

SEC source: 0000950170-23-065889 · ownership.xml · nonDerivative · entry 3

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 0

F5 · kind: Represents a distribution, and not a purchase or sale, without additional consideration by PVM VI to its members.

F4 · ownership.nature: The reportable securities are owned directly by PVM VI. PVM VI is the general partner of PVP VI and PVM VI is managed by the Managing Members. The Managing Members, one of whom is the Reporting Person who is a member of the Issuer's Board of Directors, may be deemed to have sole voting and dispositive power with respect to the shares held by PVM VI. Each of the Reporting Person and the other Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person or any of the other Managing Members is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000950170-23-065889 · ownership.xml · nonDerivative · entry 2

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 98,261

F3 · kind: Represents a change in the form of ownership of PVM VI by virtue of the receipt of shares in the in-kind distribution of common stock of the Issuer for no consideration by PVP VI.

F4 · ownership.nature: The reportable securities are owned directly by PVM VI. PVM VI is the general partner of PVP VI and PVM VI is managed by the Managing Members. The Managing Members, one of whom is the Reporting Person who is a member of the Issuer's Board of Directors, may be deemed to have sole voting and dispositive power with respect to the shares held by PVM VI. Each of the Reporting Person and the other Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person or any of the other Managing Members is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000950170-23-065889 · ownership.xml · nonDerivative · entry 1

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 3,068,136

F1 · kind: Represents a distribution, and not a purchase or sale, without additional consideration by Polaris Venture Partners VI, L.P. ("PVP VI") to its partners.

F2 · ownership.nature: The reportable securities are owned directly by PVP VI. Polaris Venture Management Co. VI, L.L.C. ("PVM VI") is the general partner of PVP VI and PVM VI is managed by its managing members, one of whom is the Reporting Person and a member of the Issuer's Board of Directors (collectively, the "Managing Members"). PVM VI may be deemed to have sole voting and dispositive power with respect to the shares held by PVP VI and each of the Reporting Person and the other Managing Members may be deemed to have shared voting and dispositive power with respect to the shares held by PVP VI. Each of the Reporting Person, PVM VI and the other Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person, PVM VI or any of the other Managing Members is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0001415889-23-014787 · form4-11032023_101154.xml · nonDerivative · entry 1

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 168,784

F1 · kind: These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2023.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $12.50 to $12.58, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range.

F3 · balance_after: Consists of 168,784 restricted stock units.

SEC source: 0001209191-23-053113 · doc4.xml · nonDerivative · entry 1

AKKARAJU SRINIVAS · CIK 0001253170 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Samsara BioCapital, L.P.

Disclosed balance after: 6,788,609

F1 · ownership.nature: Shares held by Samsara BioCapital LP ("Samsara LP"). The Reporting Person is a managing member of Samsara BioCapital GP, LLC, the general partner of Samsara LP. The Reporting Person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein.

SEC source: 0001209191-23-053111 · doc4.xml · nonDerivative · entry 1

Samsara BioCapital GP, LLC · CIK 0001888829 · 10% owner

Samsara BioCapital, L.P. · CIK 0001699737 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · By Samsara BioCapital, L.P.

Disclosed balance after: 6,788,609

F1 · ownership.nature: Shares are held by Samsara BioCapital LP ("Samsara LP"). Samsara BioCapital GP, LLC ("Samsara LLC") is the general partner of Samsara LP and may be deemed to beneficially own the shares held by Samsara LP. Dr. Srinivas Akkaraju, MD, Ph.D. has voting and investment power over the shares held by Samsara LP and, accordingly, may be deemed to beneficially own the shares held by Samsara LP. Samsara LLC disclaims beneficial ownership in these shares except to the extent of its respective pecuniary interest therein. Dr. Akkaraju is a director of Issuer and files separate Section 16 reports.

SEC source: 0000950170-23-053600 · ownership.xml · nonDerivative · entry 2

Invus Public Equities, L.P. · CIK 0001340097 · 10% owner

Artal International S.C.A. · CIK 0001218180 · 10% owner

Artal International Management S.A. · CIK 0001522131 · 10% owner

Artal Group S.A. · CIK 0001053906 · 10% owner

Westend S.A. · CIK 0001283968 · 10% owner

Stichting Administratiekantoor Westend · CIK 0001460840 · 10% owner

Wittouck Amaury · CIK 0001841311 · 10% owner

Invus Public Equities Advisors, LLC · CIK 0001340096 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,259,438

F3 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $8.20 to $8.75 per share, inclusive. The Reporting Persons undertake to provide to Scholar Rock Holding Corp, any security holder of Scholar Rock Holding Corp, or the staff of the SEC, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

F1 · ownership.direct: The Common Stock is held directly by Invus Public Equities, L.P. The general partner of Invus Public Equities, L.P. is Invus Public Equities Advisors, LLC. The Geneva branch of Artal International S.C.A. is the managing member of Invus Public Equities Advisors, LLC. The managing partner of Artal International S.C.A. is Artal International Management S.A., which is a wholly owned subsidiary of Artal Group S.A. Westend S.A. is the parent company of Artal Group, S.A., and the majority stockholder of Westend S.A. is Stichting Administratiekantoor Westend ("Stichting").

F2 · ownership.direct: (Continued from Footnote 1) Mr. Amaury Wittouck is the sole member of the board of Stichting. Each of the Reporting Persons, other than Invus Public Equities L.P., disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such reporting person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Exchange Act, each of the reporting persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.

SEC source: 0000950170-23-053600 · ownership.xml · nonDerivative · entry 1

Invus Public Equities, L.P. · CIK 0001340097 · 10% owner

Artal International S.C.A. · CIK 0001218180 · 10% owner

Artal International Management S.A. · CIK 0001522131 · 10% owner

Artal Group S.A. · CIK 0001053906 · 10% owner

Westend S.A. · CIK 0001283968 · 10% owner

Stichting Administratiekantoor Westend · CIK 0001460840 · 10% owner

Wittouck Amaury · CIK 0001841311 · 10% owner

Invus Public Equities Advisors, LLC · CIK 0001340096 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,249,288

F1 · ownership.direct: The Common Stock is held directly by Invus Public Equities, L.P. The general partner of Invus Public Equities, L.P. is Invus Public Equities Advisors, LLC. The Geneva branch of Artal International S.C.A. is the managing member of Invus Public Equities Advisors, LLC. The managing partner of Artal International S.C.A. is Artal International Management S.A., which is a wholly owned subsidiary of Artal Group S.A. Westend S.A. is the parent company of Artal Group, S.A., and the majority stockholder of Westend S.A. is Stichting Administratiekantoor Westend ("Stichting").

F2 · ownership.direct: (Continued from Footnote 1) Mr. Amaury Wittouck is the sole member of the board of Stichting. Each of the Reporting Persons, other than Invus Public Equities L.P., disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such reporting person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Exchange Act, each of the reporting persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.

SEC source: 0001415889-23-013467 · form4-09202023_110922.xml · nonDerivative · entry 1

Qatanani Mo · CIK 0001980298 · SVP AND HEAD OF RESEARCH

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 97,043

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on September 15, 2023. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to awards that were granted on October 26, 2021 and October 10, 2022. Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards vest annually over four years, subject to a continued service relationship with the Issuer on the applicable vesting date.

F2 · balance_after: Consists of 17,124 shares of common stock and 79,919 RSUs.

F3 · balance_after: The Form 3 filed by the reporting person on June 22, 2023 inadvertently overstated the number of securities beneficially owned by 5,812 shares in Table I, Column 2.

SEC source: 0001104659-23-093476 · tm2324047-1_4seq1.xml · nonDerivative · entry 1

Parlavecchio Caryn · CIK 0001922346 · CHRO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 117,199

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on August 15, 2023. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to an award that was granted on October 26, 2021. Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU award vest annually over four years, subject to a continued service relationship with the Issuer on such vesting date.

F2 · balance_after: Consists of 17,465 shares of common stock and 99,734 RSUs.

SEC source: 0001415889-23-010188 · form4-06222023_100610.xml · nonDerivative · entry 1

Parlavecchio Caryn · CIK 0001922346 · CHRO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 118,552

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on June 15, 2023. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to awards that were granted on June 16, 2022. Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards vest annually over three years, subject to a continued service relationship with the Issuer on the applicable vesting date.

F2 · balance_after: Consists of 14,618 shares of common stock and 103,934 RSUs.

SEC source: 0001415889-23-010205 · form4-06222023_110607.xml · derivative · entry 1

Reed Joshua · CIK 0001746541 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,000

Underlying: Common Stock · 36,000 shares

Expires 2033-06-21

F1 · derivative.exercise_date: This option shall vest and become fully exercisable on the earlier of the first anniversary following the date of grant or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

SEC source: 0001415889-23-010210 · form4-06222023_110642.xml · derivative · entry 1

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,000

Underlying: Common Stock · 36,000 shares

Expires 2033-06-21

F1 · derivative.exercise_date: This option shall vest and become fully exercisable on the earlier of the first anniversary following the date of grant or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

SEC source: 0001415889-23-010207 · form4-06222023_110609.xml · derivative · entry 1

Vaishnaw Akshay · CIK 0001458494 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,000

Underlying: Common Stock · 36,000 shares

Expires 2033-06-21

F1 · derivative.exercise_date: This option shall vest and become fully exercisable on the earlier of the first anniversary following the date of grant or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

SEC source: 0001415889-23-010203 · form4-06222023_110605.xml · derivative · entry 1

Gilman Michael · CIK 0001291144 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,000

Underlying: Common Stock · 36,000 shares

Expires 2033-06-21

F1 · derivative.exercise_date: This option shall vest and become fully exercisable on the earlier of the first anniversary following the date of grant or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

SEC source: 0001415889-23-010200 · form4-06222023_100615.xml · derivative · entry 1

FLIER JEFFREY S. · CIK 0001740266 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,000

Underlying: Common Stock · 36,000 shares

Expires 2033-06-21

F1 · derivative.exercise_date: This option shall vest and become fully exercisable on the earlier of the first anniversary following the date of grant or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

SEC source: 0001415889-23-010196 · form4-06222023_100654.xml · derivative · entry 1

AKKARAJU SRINIVAS · CIK 0001253170 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,000

Underlying: Common Stock · 36,000 shares

Expires 2033-06-21

F1 · derivative.exercise_date: This option shall vest and become fully exercisable on the earlier of the first anniversary following the date of grant or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

SEC source: 0001415889-23-010194 · form4-06222023_100606.xml · derivative · entry 1

Hallal David · CIK 0001457477 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,000

Underlying: Common Stock · 36,000 shares

Expires 2033-06-21

F1 · derivative.exercise_date: This option shall vest and become fully exercisable on the earlier of the first anniversary following the date of grant or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

SEC source: 0001415889-23-010186 · form4-06222023_100609.xml · nonDerivative · entry 1

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 203,791

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on June 15, 2023. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to awards that were granted on June 16, 2022. Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards vest annually over three years, subject to a continued service relationship with the Issuer on the applicable vesting date.

F2 · balance_after: Consists of 35,007 shares of common stock and 168,784 RSUs.

SEC source: 0001415889-23-010184 · form4-06222023_100631.xml · nonDerivative · entry 1

Ho Junlin · CIK 0001868114 · GENERAL COUNSEL

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 158,591

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on June 15, 2023. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to awards that were granted on June 16, 2022. Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards vest annually over three years, subject to a continued service relationship with the Issuer on the applicable vesting date.

F2 · balance_after: Consists of 47,482 shares of common stock and 111,109 RSUs.

SEC source: 0001415889-23-010215 · form4-06232023_110628.xml · derivative · entry 1

Burow Kristina · CIK 0001569248 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,000

Underlying: Common Stock · 36,000 shares

Expires 2033-06-21

F1 · derivative.exercise_date: This option shall vest and become fully exercisable on the earlier of the first anniversary following the date of grant or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

SEC source: 0000899243-23-012043 · doc4.xml · nonDerivative · entry 1

Invus Public Equities, L.P. · CIK 0001340097 · 10% owner

Artal International S.C.A. · CIK 0001218180 · 10% owner

Artal International Management S.A. · CIK 0001522131 · 10% owner

Artal Group S.A. · CIK 0001053906 · 10% owner

Westend S.A. · CIK 0001283968 · 10% owner

Wittouck Amaury · CIK 0001841311 · 10% owner

Stichting Administratiekantoor Westend · CIK 0001460840 · 10% owner

Invus Public Equities Advisors, LLC · CIK 0001340096 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,059,507

F3 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $6.40 to $6.52 per share, inclusive. The Reporting Persons undertake to provide to Scholar Rock Holding Corp, any security holder of Scholar Rock Holding Corp, or the staff of the SEC, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

F1 · ownership.direct: The Common Stock is held directly by Invus Public Equities, L.P. The general partner of Invus Public Equities, L.P. is Invus Public Equities Advisors, LLC. The Geneva branch of Artal International S.C.A. is the managing member of Invus Public Equities Advisors, LLC. The managing partner of Artal International S.C.A. is Artal International Management S.A., which is a wholly owned subsidiary of Artal Group S.A. Westend S.A. is the parent company of Artal Group, S.A., and the majority stockholder of Westend S.A. is Stichting Administratiekantoor Westend ("Stichting").

F2 · ownership.direct: (Continued from Footnote 1) Mr. Amaury Wittouck is the sole member of the board of Stichting. Each of the Reporting Persons, other than Invus Public Equities L.P., disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such reporting person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Exchange Act, each of the reporting persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.

SEC source: 0001415889-23-006405 · form4-04102023_080426.xml · derivative · entry 1

Brudnick Richard · CIK 0001692359 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 56,000

Underlying: Common Stock · 56,000 shares

Expires 2033-04-06

F1 · derivative.exercise_date: Such options shall vest in equal monthly installments during the three year period following the Transaction Date; so long as such individual continues to serve as a member of the Corporation's Board of Directors on such date.

SEC source: 0001415889-23-002612 · form4-02152023_090255.xml · derivative · entry 2

Parlavecchio Caryn · CIK 0001922346 · CHRO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 62,500

Underlying: Common Stock · 62,500 shares

Expires 2033-02-13

F3 · derivative.exercise_date: Options to vest in sixteen quarterly installments over four years, with the first quarterly installment to vest on April 1, 2023 and each additional installment to vest quarterly thereafter; provided the individual continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001415889-23-002612 · form4-02152023_090255.xml · nonDerivative · entry 1

Parlavecchio Caryn · CIK 0001922346 · CHRO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 122,590

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on February 15, 2024 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

F2 · balance_after: Consists of 6,740 shares of common stock and 115,850 RSUs.

SEC source: 0001415889-23-002611 · form4-02152023_090222.xml · derivative · entry 2

Backstrom Jay T. · CIK 0001796398 · CHIEF EXECUTIVE OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 200,000

Underlying: Common Stock · 200,000 shares

Expires 2033-02-13

F2 · derivative.exercise_date: Options to vest in sixteen quarterly installments over four years, with the first quarterly installment to vest on April 1, 2023 and each additional installment to vest quarterly thereafter; provided the individual continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001415889-23-002611 · form4-02152023_090222.xml · nonDerivative · entry 1

Backstrom Jay T. · CIK 0001796398 · CHIEF EXECUTIVE OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 150,000

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on February 15, 2024 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001415889-23-002614 · form4-02152023_090218.xml · derivative · entry 2

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 85,000

Underlying: Common Stock · 85,000 shares

Expires 2033-02-13

F3 · derivative.exercise_date: Options to vest in sixteen quarterly installments over four years, with the first quarterly installment to vest on April 1, 2023 and each additional installment to vest quarterly thereafter; provided the individual continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001415889-23-002614 · form4-02152023_090218.xml · nonDerivative · entry 1

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 210,929

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on February 15, 2024 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

F2 · balance_after: Consists of 17,229 shares of common stock and 193,700 RSUs.

SEC source: 0001415889-23-002609 · form4-02152023_090241.xml · derivative · entry 2

Ho Junlin · CIK 0001868114 · GENERAL COUNSEL

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 62,500

Underlying: Common Stock · 62,500 shares

Expires 2033-02-13

F3 · derivative.exercise_date: Options to vest in sixteen quarterly installments over four years, with the first quarterly installment to vest on April 1, 2023 and each additional installment to vest quarterly thereafter; provided the individual continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001415889-23-002609 · form4-02152023_090241.xml · nonDerivative · entry 1

Ho Junlin · CIK 0001868114 · GENERAL COUNSEL

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 162,937

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on February 15, 2024 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

F2 · balance_after: Consists of 36,662 shares of common stock and126,275 RSUs.

SEC source: 0001415889-23-001216 · form4-01192023_110138.xml · nonDerivative · entry 1

Parlavecchio Caryn · CIK 0001922346 · CHRO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,715

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on January 15, 2023. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to an award that was granted on February 14, 2022. Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU award vest annually over four years, subject to a continued service relationship with the Issuer on such applicable vesting date.

F2 · price: This price reported above represents the weighted average selling price, as the transaction was executed in multiple trades. The reporting person hereby undertakes to provide full information regarding the number of shares and prices at which the transactions were effected to the SEC staff upon request.

F3 · balance_after: Consists of 6,740 shares of common stock and 68,975 RSUs.

SEC source: 0001415889-23-001217 · form4-01192023_110141.xml · nonDerivative · entry 1

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 147,179

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on January 15, 2023. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to awards that were granted on February 1, 2021 and February 14, 2022. Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards vest annually over four years, subject to a continued service relationship with the Issuer on the applicable vesting date.

F2 · price: This price reported above represents the weighted average selling price, as the transaction was executed in multiple trades. The reporting person hereby undertakes to provide full information regarding the number of shares and prices at which the transactions were effected to the SEC staff upon request.

F3 · balance_after: Consists of 17,229 shares of common stock and 129,950 RSUs.

SEC source: 0001415889-23-001215 · form4-01192023_110140.xml · nonDerivative · entry 1

Ho Junlin · CIK 0001868114 · GENERAL COUNSEL

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 116,062

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on January 15, 2023. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to awards that were granted on February 1, 2021 and February 14, 2022. Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards vest annually over four years, subject to a continued service relationship with the Issuer on the applicable vesting date.

F2 · price: This price reported above represents the weighted average selling price, as the transaction was executed in multiple trades. The reporting person hereby undertakes to provide full information regarding the number of shares and prices at which the transactions were effected to the SEC staff upon request.

F3 · balance_after: Consists of 36,662 shares of common stock and 79,400 RSUs.

SEC source: 0000899243-23-001634 · doc4.xml · nonDerivative · entry 1

Invus Public Equities, L.P. · CIK 0001340097 · 10% owner

Artal International S.C.A. · CIK 0001218180 · 10% owner

Artal International Management S.A. · CIK 0001522131 · 10% owner

Artal Group S.A. · CIK 0001053906 · 10% owner

Westend S.A. · CIK 0001283968 · 10% owner

Stichting Administratiekantoor Westend · CIK 0001460840 · 10% owner

Wittouck Amaury · CIK 0001841311 · 10% owner

Invus Public Equities Advisors, LLC · CIK 0001340096 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,027,950

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $9.45 to $9.485 per share, inclusive. The Reporting Persons undertake to provide to Scholar Rock Holding Corp, any security holder of Scholar Rock Holding Corp, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F1 · ownership.direct: The Common Stock is held directly by Invus Public Equities, L.P. The general partner of Invus Public Equities, L.P. is Invus Public Equities Advisors, LLC. The Geneva branch of Artal International S.C.A. is the managing member of Invus Public Equities Advisors, LLC. The managing partner of Artal International S.C.A. is Artal International Management S.A., which is a wholly owned subsidiary of Artal Group S.A. Westend S.A. is the parent company of Artal Group, S.A., and the majority stockholder of Westend S.A. is Stichting Administratiekantoor Westend ("Stichting").

F2 · ownership.direct: (Continued from Footnote 1) Mr. Amaury Wittouck is the sole member of the board of Stichting. Each of the Reporting Persons, other than Invus Public Equities L.P., disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such reporting person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Exchange Act, each of the reporting persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.

SEC source: 0000899243-23-001307 · doc4.xml · nonDerivative · entry 1

Invus Public Equities, L.P. · CIK 0001340097 · 10% owner

Artal International S.C.A. · CIK 0001218180 · 10% owner

Artal International Management S.A. · CIK 0001522131 · 10% owner

Artal Group S.A. · CIK 0001053906 · 10% owner

Westend S.A. · CIK 0001283968 · 10% owner

Stichting Administratiekantoor Westend · CIK 0001460840 · 10% owner

Wittouck Amaury · CIK 0001841311 · 10% owner

Invus Public Equities Advisors, LLC · CIK 0001340096 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,029,044

F3 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $9.12 to $9.40 per share, inclusive. The Reporting Persons undertake to provide to Scholar Rock Holding Corp, any security holder of Scholar Rock Holding Corp, or the staff of the SEC, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

F1 · ownership.direct: The Common Stock is held directly by Invus Public Equities, L.P. The general partner of Invus Public Equities, L.P. is Invus Public Equities Advisors, LLC. The Geneva branch of Artal International S.C.A. is the managing member of Invus Public Equities Advisors, LLC. The managing partner of Artal International S.C.A. is Artal International Management S.A., which is a wholly owned subsidiary of Artal Group S.A. Westend S.A. is the parent company of Artal Group, S.A., and the majority stockholder of Westend S.A. is Stichting Administratiekantoor Westend ("Stichting").

F2 · ownership.direct: (Continued from Footnote 1) Mr. Amaury Wittouck is the sole member of the board of Stichting. Each of the Reporting Persons, other than Invus Public Equities L.P., disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such reporting person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Exchange Act, each of the reporting persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.

SEC source: 0001104659-22-119209 · tm2230637-2_4seq1.xml · derivative · entry 1

Marantz Jing L. · CIK 0001834528 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 250,000

Underlying: Common Stock · 250,000 shares

Expires 2032-11-14

F1 · derivative.exercise_date: Options vest over four years with 25% vesting on November 9, 2023 and the remainder vesting in 12 quarterly installments thereafter, provided the reporting person continues to have a service relationship with the Issuer as of the applicable vesting date.

SEC source: 0000899243-22-034318 · doc4.xml · nonDerivative · entry 1

Invus Public Equities, L.P. · CIK 0001340097 · 10% owner

Artal International S.C.A. · CIK 0001218180 · 10% owner

Artal International Management S.A. · CIK 0001522131 · 10% owner

Artal Group S.A. · CIK 0001053906 · 10% owner

Westend S.A. · CIK 0001283968 · 10% owner

Stichting Administratiekantoor Westend · CIK 0001460840 · 10% owner

Wittouck Amaury · CIK 0001841311 · 10% owner

Invus Public Equities Advisors, LLC · CIK 0001340096 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,980,270

F3 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $7.865 to $8.055 per share, inclusive. The Reporting Persons undertake to provide to Scholar Rock Holding Corp, any security holder of Scholar Rock Holding Corp, or the staff of the SEC, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

F1 · ownership.direct: The Common Stock is held directly by Invus Public Equities, L.P. The general partner of Invus Public Equities, L.P. is Invus Public Equities Advisors, LLC. The Geneva branch of Artal International S.C.A. is the managing member of Invus Public Equities Advisors, LLC. The managing partner of Artal International S.C.A. is Artal International Management S.A., which is a wholly owned subsidiary of Artal Group S.A. Westend S.A. is the parent company of Artal Group, S.A., and the majority stockholder of Westend S.A. is Stichting Administratiekantoor Westend ("Stichting").

F2 · ownership.direct: (Continued from Footnote 1) Mr. Amaury Wittouck is the sole member of the board of Stichting. Each of the Reporting Persons, other than Invus Public Equities L.P., disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such reporting person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Exchange Act, each of the reporting persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.

SEC source: 0000899243-22-033263 · doc4.xml · nonDerivative · entry 2

Invus Public Equities, L.P. · CIK 0001340097 · 10% owner

Artal International S.C.A. · CIK 0001218180 · 10% owner

Artal International Management S.A. · CIK 0001522131 · 10% owner

Artal Group S.A. · CIK 0001053906 · 10% owner

Westend S.A. · CIK 0001283968 · 10% owner

Stichting Administratiekantoor Westend · CIK 0001460840 · 10% owner

Wittouck Amaury · CIK 0001841311 · 10% owner

Invus Public Equities Advisors, LLC · CIK 0001340096 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,850,005

F4 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $7.06 to $8.11 per share, inclusive. The Reporting Persons undertake to provide to Scholar Rock Holding Corp, any security holder of Scholar Rock Holding Corp, or the staff of the SEC, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

F1 · ownership.direct: The Common Stock is held directly by Invus Public Equities, L.P. The general partner of Invus Public Equities, L.P. is Invus Public Equities Advisors, LLC. The Geneva branch of Artal International S.C.A. is the managing member of Invus Public Equities Advisors, LLC. The managing partner of Artal International S.C.A. is Artal International Management S.A., which is a wholly owned subsidiary of Artal Group S.A. Westend S.A. is the parent company of Artal Group, S.A., and the majority stockholder of Westend S.A. is Stichting Administratiekantoor Westend ("Stichting").

F2 · ownership.direct: (Continued from Footnote 1) Mr. Amaury Wittouck is the sole member of the board of Stichting. Each of the Reporting Persons, other than Invus Public Equities L.P., disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such reporting person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Exchange Act, each of the reporting persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.

SEC source: 0000899243-22-033263 · doc4.xml · nonDerivative · entry 1

Invus Public Equities, L.P. · CIK 0001340097 · 10% owner

Artal International S.C.A. · CIK 0001218180 · 10% owner

Artal International Management S.A. · CIK 0001522131 · 10% owner

Artal Group S.A. · CIK 0001053906 · 10% owner

Westend S.A. · CIK 0001283968 · 10% owner

Stichting Administratiekantoor Westend · CIK 0001460840 · 10% owner

Wittouck Amaury · CIK 0001841311 · 10% owner

Invus Public Equities Advisors, LLC · CIK 0001340096 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,784,005

F3 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $6.77 to $7.24 per share, inclusive. The Reporting Persons undertake to provide to Scholar Rock Holding Corp, any security holder of Scholar Rock Holding Corp, or the staff of the SEC, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

F1 · ownership.direct: The Common Stock is held directly by Invus Public Equities, L.P. The general partner of Invus Public Equities, L.P. is Invus Public Equities Advisors, LLC. The Geneva branch of Artal International S.C.A. is the managing member of Invus Public Equities Advisors, LLC. The managing partner of Artal International S.C.A. is Artal International Management S.A., which is a wholly owned subsidiary of Artal Group S.A. Westend S.A. is the parent company of Artal Group, S.A., and the majority stockholder of Westend S.A. is Stichting Administratiekantoor Westend ("Stichting").

F2 · ownership.direct: (Continued from Footnote 1) Mr. Amaury Wittouck is the sole member of the board of Stichting. Each of the Reporting Persons, other than Invus Public Equities L.P., disclaims beneficial ownership of the securities held by the other Reporting Persons, except to the extent of such reporting person's pecuniary interest therein, and, pursuant to Rule 16a-1(a)(4) under the Exchange Act, each of the reporting persons (other than to the extent it directly holds securities reported herein) states that the inclusion of these securities in this report shall not be deemed an admission of beneficial ownership of all of the reported securities for purposes of Section 16 of the Exchange Act or for any other purpose.

SEC source: 0001104659-22-102341 · tm2226370-2_4seq1.xml · derivative · entry 1

Backstrom Jay T. · CIK 0001796398 · CEO-Elect

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,000,000

Underlying: Common Stock · 1,000,000 shares

Expires 2032-09-20

F1 · derivative.exercise_date: Options vest over four years with 25% vesting on September 20, 2023 and the remainder vesting in 12 quarterly installments thereafter, provided the reporting person continues to have a service relationship with the Issuer on such applicable vesting date.

SEC source: 0001104659-22-101568 · tm2226156-2_4seq1.xml · derivative · entry 1

AKKARAJU SRINIVAS · CIK 0001253170 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,000

Underlying: Common Stock · 56,000 shares

Expires 2032-09-16

F1 · derivative.exercise_date: This option vests monthly over three (3) years following the date of appointment, with the first monthly amount having vested on August 26, 2022; provided that Mr. Akkaraju continues to serve on the Board of Directors of Issuer on the applicable monthly vesting date.

SEC source: 0001104659-22-092230 · tm2223683-1_4seq1.xml · nonDerivative · entry 1

Parlavecchio Caryn · CIK 0001922346 · CHRO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 78,649

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on August 15, 2022. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to an award that was granted on October 26, 2021. Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU award will vest annually over four years, with the first annual installment to vest on August 15, 2022 and each additional installment to vest annually thereafter, subject to a continued service relationship with the Issuer on such vesting date.

F2 · balance_after: Consists of 2,799 shares of common stock and 75,850 RSUs.

SEC source: 0001104659-22-079223 · tm2220827-1_4seq1.xml · nonDerivative · entry 2

Gilman Michael · CIK 0001291144 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Trust

Disclosed balance after: 37,459

F1 · price: This transaction represents the transfer of common stock by bona fide gift from the reporting person to the Michael Gilman Irrevocable Trust of 2016, a trust held for the benefit of the reporting person's spouse and children. The reporting person's spouse is a trustee of the trust.

SEC source: 0001104659-22-079223 · tm2220827-1_4seq1.xml · nonDerivative · entry 1

Gilman Michael · CIK 0001291144 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · price: This transaction represents the transfer of common stock by bona fide gift from the reporting person to the Michael Gilman Irrevocable Trust of 2016, a trust held for the benefit of the reporting person's spouse and children. The reporting person's spouse is a trustee of the trust.

SEC source: 0000899243-22-023965 · doc4.xml · derivative · entry 5

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 16,536

Underlying: Common Stock · 16,536 shares

Expires 2025-12-31

F1 · price: The securities were purchased at a combined public offering price of $4.90 per share of common stock, and such combined offering price included accompanying Common Warrants.

F4 · ownership.nature: The securities are owned directly by Polaris Venture Partners Founders' Fund VI, L.P. ("PVPFF VI"). PVM VI is the general partner of PVPFF VI. PVM VI may be deemed to have sole voting and dispositive power with respect to the shares held by PVPFF VI and each of the Reporting Person and the other Managing Members may be deemed to have shared voting and dispositive power with respect to the shares held by PVPFF VI. Each of the Reporting Person, PVM VI and the other Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person, PVM VI or any of the other Managing Members is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-22-023965 · doc4.xml · derivative · entry 4

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 282,962

Underlying: Common Stock · 282,962 shares

Expires 2025-12-31

F1 · price: The securities were purchased at a combined public offering price of $4.90 per share of common stock, and such combined offering price included accompanying Common Warrants.

F2 · ownership.nature: The securities are owned directly by Polaris Venture Partners VI, L.P. ("PVP VI"). Polaris Venture Management Co. VI, L.L.C. ("PVM VI") is the general partner of PVP VI and PVM VI is managed by its managing members, one of whom is the Reporting Person and a member of the Issuer's Board of Directors (collectively, the "Managing Members"). PVM VI may be deemed to have sole voting and dispositive power with respect to the shares held by PVP VI and each of the Reporting Person and the other Managing Members may be deemed to have shared voting and dispositive power with respect to the shares held by PVP VI.

F3 · ownership.nature: (Continued from Footnote 2) Each of the Reporting Person, PVM VI and the other Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that the Reporting Person, PVM VI or any of the other Managing Members is a beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.