SRRK

SEC source: 0001104659-25-052471 · tm2516084-2_4seq1.xml · nonDerivative · entry 1

Gilman Michael · CIK 0001291144 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 58,591

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest on the earlier of June 15, 2026 or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

F2 · balance_after: Consists of 50,959 shares of Common Stock and 7,632 RSUs.

SEC source: 0001104659-25-052470 · tm2516084-1_4seq1.xml · derivative · entry 3

FLIER JEFFREY S. · CIK 0001740266 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,206

Underlying: Common Stock · 9,206 shares

Expires 2035-05-22

F4 · derivative.exercise_date: Options to vest and become fully exercisable on the earlier of the first anniversary following the date of grant or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

SEC source: 0001104659-25-052470 · tm2516084-1_4seq1.xml · nonDerivative · entry 1

FLIER JEFFREY S. · CIK 0001740266 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,145

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest on the earlier of June 15, 2026 or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

F2 · balance_after: Consists of 22,513 shares of Common Stock and 7,632 RSUs.

SEC source: 0001104659-25-045117 · tm2513936-4_4seq1.xml · derivative · entry 1

Woods Keith · CIK 0001996804 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 110,067

Underlying: Common Stock · 110,067 shares

Expires 2035-05-02

F1 · derivative.exercise_date: 25% of the shares underlying this option shall vest on April 27, 2026, with the remainder vesting in twelve equal quarterly installments thereafter; provided the reporting person continues to have a service relationship with the Issuer on each such vesting date.

SEC source: 0001104659-25-045116 · tm2513936-3_4seq1.xml · derivative · entry 1

Vaishnaw Akshay · CIK 0001458494 · Director · President of R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 110,067

Underlying: Common Stock · 110,067 shares

Expires 2035-05-02

F1 · derivative.exercise_date: 25% of the shares underlying this option shall vest on April 27, 2026, with the remainder vesting in twelve equal quarterly installments thereafter; provided the reporting person continues to have a service relationship with the Issuer on each such vesting date.

SEC source: 0001104659-25-045114 · tm2513936-2_4seq1.xml · derivative · entry 1

Sinha Vikas · CIK 0001337845 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 110,067

Underlying: Common Stock · 110,067 shares

Expires 2035-05-02

F1 · derivative.exercise_date: 25% of the shares underlying this option shall vest on April 27, 2026, with the remainder vesting in twelve equal quarterly installments thereafter; provided the reporting person continues to have a service relationship with the Issuer on each such vesting date.

SEC source: 0001104659-25-045112 · tm2513936-1_4seq1.xml · derivative · entry 1

Hallal David · CIK 0001457477 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 275,167

Underlying: Common Stock · 275,167 shares

Expires 2035-05-02

F1 · derivative.exercise_date: 25% of the shares underlying this option shall vest on April 27, 2026, with the remainder vesting in twelve equal quarterly installments thereafter; provided the reporting person continues to have a service relationship with the Issuer on each such vesting date.

SEC source: 0001104659-25-041460 · tm2513505-6_4seq1.xml · nonDerivative · entry 2

Vaishnaw Akshay · CIK 0001458494 · Director · President of R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 622,955

F2 · shares: Represents performance based RSUs subject to performance- and time-based vesting conditions (the "PSUs"). The amount reported herein represents the maximum number of shares of the Issuer's common stock that may be issued under this award. The shares subject to this PSU vest in tranches of a combination of performance vesting tied to the Issuer's common stock achieving certain price targets and time-based vesting over four years, provided the reporting person continues to have a service relationship with the Issuer on each such vesting date. Any PSUs that have not vested on or prior to April 27, 2029 will be forfeited for no consideration.

SEC source: 0001104659-25-041460 · tm2513505-6_4seq1.xml · nonDerivative · entry 1

Vaishnaw Akshay · CIK 0001458494 · Director · President of R&D

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 122,955

F1 · shares: Represents restricted stock units ("RSUs") subject to time-based vesting conditions. Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on April 15, 2026 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on each such vesting date.

SEC source: 0001104659-25-041464 · tm2513505-7_4seq1.xml · nonDerivative · entry 2

Woods Keith · CIK 0001996804 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 600,000

F2 · shares: Represents performance based RSUs subject to performance- and time-based vesting conditions (the "PSUs"). The amount reported herein represents the maximum number of shares of the Issuer's common stock that may be issued under this award. The shares subject to this PSU vest in tranches of a combination of performance vesting tied to the Issuer's common stock achieving certain price targets and time-based vesting over four years, provided the reporting person continues to have a service relationship with the Issuer on each such vesting date. Any PSUs that have not vested on or prior to April 27, 2029 will be forfeited for no consideration.

SEC source: 0001104659-25-041464 · tm2513505-7_4seq1.xml · nonDerivative · entry 1

Woods Keith · CIK 0001996804 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

F1 · shares: Represents restricted stock units ("RSUs") subject to time-based vesting conditions. Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on April 15, 2026 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on each such vesting date.

SEC source: 0001104659-25-041457 · tm2513505-5_4seq1.xml · nonDerivative · entry 2

Hallal David · CIK 0001457477 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,804,095

F2 · shares: Represents performance based RSUs subject to performance- and time-based vesting conditions (the "PSUs"). The amount reported herein represents the maximum number of shares of the Issuer's common stock that may be issued under this award. The shares subject to this PSU vest in tranches of a combination of performance vesting tied to the Issuer's common stock achieving certain price targets and time-based vesting over four years, provided the reporting person continues to have a service relationship with the Issuer on each such vesting date. Any PSUs that have not vested on or prior to April 27, 2029 will be forfeited for no consideration.

SEC source: 0001104659-25-041457 · tm2513505-5_4seq1.xml · nonDerivative · entry 1

Hallal David · CIK 0001457477 · Director · CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 554,095

F1 · shares: Represents restricted stock units ("RSUs") subject to time-based vesting conditions. Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on April 15, 2026 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on each such vesting date.

SEC source: 0001104659-25-041454 · tm2513505-4_4seq1.xml · nonDerivative · entry 2

Sinha Vikas · CIK 0001337845 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 600,000

F2 · shares: Represents performance based RSUs subject to performance- and time-based vesting conditions (the "PSUs"). The amount reported herein represents the maximum number of shares of the Issuer's common stock that may be issued under this award. The shares subject to this PSU vest in tranches of a combination of performance vesting tied to the Issuer's common stock achieving certain price targets and time-based vesting over four years, provided the reporting person continues to have a service relationship with the Issuer on each such vesting date. Any PSUs that have not vested on or prior to April 27, 2029 will be forfeited for no consideration.

SEC source: 0001104659-25-041454 · tm2513505-4_4seq1.xml · nonDerivative · entry 1

Sinha Vikas · CIK 0001337845 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

F1 · shares: Represents restricted stock units ("RSUs") subject to time-based vesting conditions. Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on April 15, 2026 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on each such vesting date.

SEC source: 0001104659-25-041451 · tm2513505-1_4seq1.xml · derivative · entry 4

Sacco Tracey · CIK 0001980334 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 185,000

Underlying: Common Stock · 5,000 shares

Expires 2033-02-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 20, 2024.

F7 · derivative.exercise_date: 112,500 shares remain unvested under this stock option. The first vesting event occurred on February 6, 2024 and the remainder vests in twelve quarterly installments thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001104659-25-041451 · tm2513505-1_4seq1.xml · nonDerivative · entry 3

Sacco Tracey · CIK 0001980334 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 71,750

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 20, 2024.

F5 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $33.37 to $33.53, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F6 · balance_after: Consists of 6,931 shares of common stock and 64,819 RSUs.

SEC source: 0001104659-25-041451 · tm2513505-1_4seq1.xml · nonDerivative · entry 2

Sacco Tracey · CIK 0001980334 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 71,834

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 20, 2024.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $32.46 to $33.36, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F4 · balance_after: Consists of 7,015 shares of common stock and 64,819 RSUs.

SEC source: 0001104659-25-041451 · tm2513505-1_4seq1.xml · nonDerivative · entry 1

Sacco Tracey · CIK 0001980334 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 76,250

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 20, 2024.

F2 · balance_after: Consists of 11,931 shares of common stock and 64,819 RSUs.

SEC source: 0001415889-25-008976 · form4-03252025_110328.xml · derivative · entry 4

Sacco Tracey · CIK 0001980334 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 190,000

Underlying: Common Stock · 5,000 shares

Expires 2033-02-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 20, 2024.

F7 · derivative.exercise_date: 112,500 shares remain unvested under this stock option. The first vesting event occurred on February 6, 2024 and the remainder vests in twelve quarterly installments thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001415889-25-008976 · form4-03252025_110328.xml · nonDerivative · entry 3

Sacco Tracey · CIK 0001980334 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 71,750

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 20, 2024.

F5 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $32.52 to $33.44, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F6 · balance_after: Consists of 6,931 shares of common stock and 64,819 RSUs.

SEC source: 0001415889-25-008976 · form4-03252025_110328.xml · nonDerivative · entry 2

Sacco Tracey · CIK 0001980334 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 76,750

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 20, 2024.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $33.52 to $34.02, inclusive. Full information regarding the number of shares sold at each.

F4 · balance_after: Consists of 11,931 shares of common stock and 64,819 RSUs.

SEC source: 0001415889-25-008976 · form4-03252025_110328.xml · nonDerivative · entry 1

Sacco Tracey · CIK 0001980334 · Chief Commercial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 78,250

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 20, 2024.

F2 · balance_after: Consists of 13,431 shares of common stock and 64,819 RSUs.

SEC source: 0001415889-25-008972 · form4-03252025_110359.xml · derivative · entry 5

Moore Erin · CIK 0001790859 · Interim PFO and PAO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 40,724

Underlying: Common Stock · 8,564 shares

Expires 2030-02-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 18, 2024.

F6 · derivative.exercise_date: No shares remain unvested under this stock option.

SEC source: 0001415889-25-008972 · form4-03252025_110359.xml · derivative · entry 4

Moore Erin · CIK 0001790859 · Interim PFO and PAO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 11,764

Underlying: Common Stock · 5,000 shares

Expires 2028-10-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 18, 2024.

F6 · derivative.exercise_date: No shares remain unvested under this stock option.

SEC source: 0001415889-25-008972 · form4-03252025_110359.xml · nonDerivative · entry 3

Moore Erin · CIK 0001790859 · Interim PFO and PAO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 82,609

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 18, 2024.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $33.00 to $33.55, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F5 · balance_after: Consists of 15,380 shares of common stock and 67,229 RSUs.

SEC source: 0001415889-25-008972 · form4-03252025_110359.xml · nonDerivative · entry 2

Moore Erin · CIK 0001790859 · Interim PFO and PAO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 96,173

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 18, 2024.

F3 · balance_after: Consists of 28,944 shares of common stock and 67,229 RSUs.

SEC source: 0001415889-25-008972 · form4-03252025_110359.xml · nonDerivative · entry 1

Moore Erin · CIK 0001790859 · Interim PFO and PAO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 87,609

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on December 18, 2024.

F2 · balance_after: Consists of 20,380 shares of common stock and 67,229 RSUs.

SEC source: 0001415889-25-008593 · form4-03192025_050301.xml · nonDerivative · entry 1

Peng Katie · CIK 0001983850 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 30,319

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted on November 20, 2024 to cover tax obligations upon the vesting and settlement of restricted stock units.

F2 · balance_after: Consists of 8,680 shares of common stock and 21,639 RSUs.

SEC source: 0001415889-25-007841 · form4-03122025_050316.xml · derivative · entry 2

Parlavecchio Caryn · CIK 0001922346 · CHRO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,430

Underlying: Common Stock · 31,430 shares

Expires 2035-03-10

F3 · derivative.exercise_date: Options to vest in sixteen quarterly installments over four years, with the first quarterly installment to vest on April 1, 2025 and each additional installment to vest quarterly thereafter; provided the individual continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001415889-25-007841 · form4-03122025_050316.xml · nonDerivative · entry 1

Parlavecchio Caryn · CIK 0001922346 · CHRO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 163,828

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on February 15, 2026 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

F2 · balance_after: Consists of 58,469 shares of common stock and 105,359 RSUs

SEC source: 0001415889-25-007839 · form4-03122025_050311.xml · derivative · entry 2

Backstrom Jay T. · CIK 0001796398 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 151,430

Underlying: Common Stock · 151,430 shares

Expires 2035-03-10

F3 · derivative.exercise_date: Options to vest in sixteen quarterly installments over four years, with the first quarterly installment to vest on April 1, 2025 and each additional installment to vest quarterly thereafter; provided the individual continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001415889-25-007839 · form4-03122025_050311.xml · nonDerivative · entry 1

Backstrom Jay T. · CIK 0001796398 · Director · CHIEF EXECUTIVE OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 425,561

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on February 15, 2026 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

F2 · balance_after: Consists of 76,277 shares of common stock and 349,284 RSUs

SEC source: 0001104659-25-023059 · tm259035-1_4seq1.xml · derivative · entry 12

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 53,573

Underlying: Common Stock · 17,857 shares

Expires 2034-02-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 19, 2024.

F15 · derivative.exercise_date: Options to vest in sixteen quarterly installments over four years, with the first quarterly installment to vest on April 1, 2024 and each additional installment to vest quarterly thereafter; provided the individual continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001104659-25-023059 · tm259035-1_4seq1.xml · derivative · entry 11

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 42,500

Underlying: Common Stock · 5,313 shares

Expires 2033-02-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 19, 2024.

F14 · derivative.exercise_date: The shares underlying this option vest in sixteen quarterly installments over four years, with the first quarterly installment vested on April 1, 2023 and each additional installment to vest quarterly thereafter; provided the individual continues to have a service relationship with the Issuer on each such vesting date.

SEC source: 0001104659-25-023059 · tm259035-1_4seq1.xml · derivative · entry 10

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,462

Underlying: Common Stock · 24,915 shares

Expires 2032-06-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 19, 2024.

F13 · derivative.exercise_date: Options vest and become exercisable in twelve quarterly installments over three years, with the first quarterly installment to vest on September 16, 2022 and each additional installment to vest quarterly thereafter, provided the individual continues to have a service relationship with the Company on such vesting date.

SEC source: 0001104659-25-023059 · tm259035-1_4seq1.xml · derivative · entry 9

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 14,378

Underlying: Common Stock · 43,122 shares

Expires 2032-02-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 19, 2024.

F12 · derivative.exercise_date: Options vest and become exercisable in sixteen quarterly installments over four years. Vesting commenced on January 1, 2022 and the first vesting event shall occur three months thereafter; provided the reporting person continues to have a service relationship with the Company on such vesting date.

SEC source: 0001104659-25-023059 · tm259035-1_4seq1.xml · derivative · entry 8

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 21,690 shares

Expires 2030-07-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 19, 2024.

F11 · derivative.exercise_date: 100% of the shares underlying the option are fully vested.

SEC source: 0001104659-25-023059 · tm259035-1_4seq1.xml · nonDerivative · entry 7

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 111,345

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 19, 2024.

F9 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $34.53 to $35.025, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F10 · balance_after: Consists of 111,345 RSUs.

SEC source: 0001104659-25-023059 · tm259035-1_4seq1.xml · nonDerivative · entry 6

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 140,740

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 19, 2024.

F7 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $35.03 to $35.765, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F8 · balance_after: Consists of 29,395 shares of common stock and 111,345 RSUs.

SEC source: 0001104659-25-023059 · tm259035-1_4seq1.xml · nonDerivative · entry 5

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 253,637

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 19, 2024.

F6 · balance_after: Consists of 142,292 shares of common stock and 111,345 RSUs.

SEC source: 0001104659-25-023059 · tm259035-1_4seq1.xml · nonDerivative · entry 4

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 235,780

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 19, 2024.

F5 · balance_after: Consists of 124,435 shares of common stock and 111,345 RSUs.

SEC source: 0001104659-25-023059 · tm259035-1_4seq1.xml · nonDerivative · entry 3

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 230,467

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 19, 2024.

F4 · balance_after: Consists of 119,122 shares of common stock and 111,345 RSUs.

SEC source: 0001104659-25-023059 · tm259035-1_4seq1.xml · nonDerivative · entry 2

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 205,552

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 19, 2024.

F3 · balance_after: Consists of 94,207 shares of common stock and 111,345 RSUs.

SEC source: 0001104659-25-023059 · tm259035-1_4seq1.xml · nonDerivative · entry 1

Myles Edward H · CIK 0001358219 · COO & CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 162,430

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on November 19, 2024.

F2 · balance_after: Consists of 51,085 shares of common stock and 111,345 restricted stock units ("RSUs").

SEC source: 0001415889-25-007842 · form4-03122025_050318.xml · derivative · entry 2

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,855

Underlying: Common Stock · 42,855 shares

Expires 2035-03-10

F3 · derivative.exercise_date: Options to vest in sixteen quarterly installments over four years, with the first quarterly installment to vest on April 1, 2025 and each additional installment to vest quarterly thereafter; provided the individual continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001415889-25-007842 · form4-03122025_050318.xml · nonDerivative · entry 1

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 143,229

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on February 15, 2026 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

F2 · balance_after: Consists of 20,259 shares of common stock and 122,970 RSUs

SEC source: 0001415889-25-007840 · form4-03122025_050314.xml · derivative · entry 2

Marantz Jing L. · CIK 0001834528 · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,715

Underlying: Common Stock · 45,715 shares

Expires 2035-03-10

F3 · derivative.exercise_date: Options to vest in sixteen quarterly installments over four years, with the first quarterly installment to vest on April 1, 2025 and each additional installment to vest quarterly thereafter; provided the individual continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001415889-25-007840 · form4-03122025_050314.xml · nonDerivative · entry 1

Marantz Jing L. · CIK 0001834528 · CHIEF MEDICAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 101,485

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest in four annual installments over four years, with the first annual installment to vest on February 15, 2026 and each additional installment to vest annually thereafter; provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

F2 · balance_after: Consists of 12,558 shares of common stock and 88,927 RSUs

SEC source: 0001415889-25-007837 · form4-03122025_050307.xml · derivative · entry 2

Sacco Tracey · CIK 0001980334 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,145

Underlying: Common Stock · 37,145 shares

Expires 2035-03-10

F3 · derivative.exercise_date: Options to vest in sixteen quarterly installments over four years, with the first quarterly installment to vest on April 1, 2025 and each additional installment to vest quarterly thereafter; provided the individual continues to have a service relationship with the Issuer on such vesting date.