SRRK

SEC source: 0001253170-25-000025 · form4-12172025_021252.xml · nonDerivative · entry 2

AKKARAJU SRINIVAS · CIK 0001253170 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Samsara Opportunity Fund, L.P.

Disclosed balance after: 525,635

F3 · price: The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions at prices ranging from $39.8512 to $40.85 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities purchased at each separate price within the range set forth in this footnote.

F2 · ownership.nature: Securities are directly held by Samsara Opportunity Fund, L.P. ("Samsara Opportunity Fund"). Samsara Opportunity Fund GP, LLC ("Samsara Opportunity GP") is the general partner of Samsara Opportunity Fund and may be deemed to beneficially own the securities held by Samsara Opportunity Fund. The Reporting Person has voting and investment power over the securities held by Samsara Opportunity Fund and, accordingly, may be deemed to beneficially own the securities held by Samsara Opportunity Fund. The Reporting Person disclaims beneficial ownership in these securities except to the extent of his pecuniary interest therein.

SEC source: 0001253170-25-000025 · form4-12172025_021252.xml · nonDerivative · entry 1

AKKARAJU SRINIVAS · CIK 0001253170 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Samsara Opportunity Fund, L.P.

Disclosed balance after: 513,235

F1 · price: The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions at prices ranging from $38.85 to $39.849 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities purchased at each separate price within the range set forth in this footnote.

F2 · ownership.nature: Securities are directly held by Samsara Opportunity Fund, L.P. ("Samsara Opportunity Fund"). Samsara Opportunity Fund GP, LLC ("Samsara Opportunity GP") is the general partner of Samsara Opportunity Fund and may be deemed to beneficially own the securities held by Samsara Opportunity Fund. The Reporting Person has voting and investment power over the securities held by Samsara Opportunity Fund and, accordingly, may be deemed to beneficially own the securities held by Samsara Opportunity Fund. The Reporting Person disclaims beneficial ownership in these securities except to the extent of his pecuniary interest therein.

SEC source: 0001253170-25-000006 · form4-10082025_121015.xml · nonDerivative · entry 6

AKKARAJU SRINIVAS · CIK 0001253170 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Samsara Opportunity Fund, L.P.

Disclosed balance after: 500,439

F7 · price: The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions at prices ranging from $39.23 to $39.84 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities purchased at each separate price within the range set forth in this footnote.

F2 · ownership.nature: Securities are directly held by Samsara Opportunity Fund, L.P. ("Samsara Opportunity Fund"). Samsara Opportunity Fund GP, LLC ("Samsara Opportunity GP") is the general partner of Samsara Opportunity Fund and may be deemed to beneficially own the securities held by Samsara Opportunity Fund. The Reporting Person has voting and investment power over the shares held by Samsara Opportunity Fund and, accordingly, may be deemed to beneficially own the shares held by Samsara Opportunity Fund. The Reporting Person disclaims beneficial ownership in these securities except to the extent of his pecuniary interest therein.

SEC source: 0001253170-25-000006 · form4-10082025_121015.xml · nonDerivative · entry 5

AKKARAJU SRINIVAS · CIK 0001253170 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Samsara Opportunity Fund, L.P.

Disclosed balance after: 486,691

F6 · price: The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions at prices ranging from $38.23 to $39.2298 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities purchased at each separate price within the range set forth in this footnote.

F2 · ownership.nature: Securities are directly held by Samsara Opportunity Fund, L.P. ("Samsara Opportunity Fund"). Samsara Opportunity Fund GP, LLC ("Samsara Opportunity GP") is the general partner of Samsara Opportunity Fund and may be deemed to beneficially own the securities held by Samsara Opportunity Fund. The Reporting Person has voting and investment power over the shares held by Samsara Opportunity Fund and, accordingly, may be deemed to beneficially own the shares held by Samsara Opportunity Fund. The Reporting Person disclaims beneficial ownership in these securities except to the extent of his pecuniary interest therein.

SEC source: 0001253170-25-000006 · form4-10082025_121015.xml · nonDerivative · entry 4

AKKARAJU SRINIVAS · CIK 0001253170 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Samsara Opportunity Fund, L.P.

Disclosed balance after: 405,828

F5 · price: The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions at prices ranging from $37.23 to $38.2276 inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities purchased at each separate price within the range set forth in this footnote.

SEC source: 0001253170-25-000006 · form4-10082025_121015.xml · nonDerivative · entry 3

AKKARAJU SRINIVAS · CIK 0001253170 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Samsara Opportunity Fund, L.P.

Disclosed balance after: 387,414

F4 · price: The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions at prices ranging from $37.14 to $37.6227 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities purchased at each separate price within the range set forth in this footnote.

F2 · ownership.nature: Securities are directly held by Samsara Opportunity Fund, L.P. ("Samsara Opportunity Fund"). Samsara Opportunity Fund GP, LLC ("Samsara Opportunity GP") is the general partner of Samsara Opportunity Fund and may be deemed to beneficially own the securities held by Samsara Opportunity Fund. The Reporting Person has voting and investment power over the shares held by Samsara Opportunity Fund and, accordingly, may be deemed to beneficially own the shares held by Samsara Opportunity Fund. The Reporting Person disclaims beneficial ownership in these securities except to the extent of his pecuniary interest therein.

SEC source: 0001253170-25-000006 · form4-10082025_121015.xml · nonDerivative · entry 2

AKKARAJU SRINIVAS · CIK 0001253170 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Samsara Opportunity Fund, L.P.

Disclosed balance after: 67,714

F3 · price: The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions at prices ranging from $36.14 to $37.1391 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities purchased at each separate price within the range set forth in this footnote.

F2 · ownership.nature: Securities are directly held by Samsara Opportunity Fund, L.P. ("Samsara Opportunity Fund"). Samsara Opportunity Fund GP, LLC ("Samsara Opportunity GP") is the general partner of Samsara Opportunity Fund and may be deemed to beneficially own the securities held by Samsara Opportunity Fund. The Reporting Person has voting and investment power over the shares held by Samsara Opportunity Fund and, accordingly, may be deemed to beneficially own the shares held by Samsara Opportunity Fund. The Reporting Person disclaims beneficial ownership in these securities except to the extent of his pecuniary interest therein.

SEC source: 0001253170-25-000006 · form4-10082025_121015.xml · nonDerivative · entry 1

AKKARAJU SRINIVAS · CIK 0001253170 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Samsara Opportunity Fund, L.P.

Disclosed balance after: 11,011

F1 · price: The price reported in Column 4 is a weighted average price. These securities were purchased in multiple transactions at prices ranging from $35.14 to $36.13 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities purchased at each separate price within the range set forth in this footnote.

F2 · ownership.nature: Securities are directly held by Samsara Opportunity Fund, L.P. ("Samsara Opportunity Fund"). Samsara Opportunity Fund GP, LLC ("Samsara Opportunity GP") is the general partner of Samsara Opportunity Fund and may be deemed to beneficially own the securities held by Samsara Opportunity Fund. The Reporting Person has voting and investment power over the shares held by Samsara Opportunity Fund and, accordingly, may be deemed to beneficially own the shares held by Samsara Opportunity Fund. The Reporting Person disclaims beneficial ownership in these securities except to the extent of his pecuniary interest therein.

SEC source: 0001980298-25-000005 · form4-09242025_040903.xml · nonDerivative · entry 1

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 108,964

F1 · shares: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $30.33 to $30.85, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F3 · balance_after: Consists of 108,964 RSUs.

SEC source: 0001983850-25-000003 · form4-09172025_040903.xml · nonDerivative · entry 2

Peng Katie · CIK 0001983850 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 33,914

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted on November 20, 2024 to cover tax obligations upon the vesting and settlement of restricted stock units ("RSUs").

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $32.85 to $33.73, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F5 · balance_after: Consists of 13,614 shares of common stock and 20,300 RSUs.

SEC source: 0001983850-25-000003 · form4-09172025_040903.xml · nonDerivative · entry 1

Peng Katie · CIK 0001983850 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 33,990

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted on November 20, 2024 to cover tax obligations upon the vesting and settlement of restricted stock units ("RSUs").

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $31.85 to $32.83, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F3 · balance_after: Consists of 13,690 shares of common stock and 20,300 RSUs.

SEC source: 0001980298-25-000003 · form4-09172025_040901.xml · nonDerivative · entry 1

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 112,317

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on September 15, 2025. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to awards that were granted on October 26, 2021 and October 10, 2022. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards vest annually over four years, subject to a continued service relationship with the Issuer on the applicable vesting date.

F2 · balance_after: Consists of 3,353 shares of common stock and 108,964 RSUs.

SEC source: 0001415889-25-022310 · form4-08192025_040803.xml · nonDerivative · entry 1

Parlavecchio Caryn · CIK 0001922346 · CHRO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 155,464

F1 · shares: Represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSU") on August 15, 2025. This sale is mandated by the Issuer's election under its equity incentive plans to require the reporting person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the reporting person. The shares vested pursuant to awards that were granted on October 26, 2021. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards are fully vested.

F2 · balance_after: Consists of 66,222 shares of common stock and 89,242 RSUs.

SEC source: 0001415889-25-020011 · form4-07182025_040701.xml · nonDerivative · entry 1

FLIER JEFFREY S. · CIK 0001740266 · Director

10b5-1 filing: Plan reported

Ownership: Indirect · Trust

Disclosed balance after: 0

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2025.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $40.00 to $40.075, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F3 · ownership.nature: Represents shares owned directly by The Jeffrey S. Flier Family Trust - 2014, for which the Reporting Person's spouse, Eleftheria Maratos-Flier, and Samuel C. Sichko are trustees. The Reporting Person disclaims Section 16 beneficial ownership of these securities, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for Section 16 or any other purpose.

SEC source: 0001104659-25-067088 · tm2520599-1_4seq1.xml · nonDerivative · entry 1

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 115,495

F1 · shares: This transaction was effected by the Reporting Person pursuant to a Rule 10b5-1 trading plan adopted on March 31, 2025.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $32.45 to $44.32, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F3 · balance_after: Consists of 0 shares of common stock and 115,495 RSUs.

SEC source: 0001415889-25-018187 · form4-06252025_040601.xml · derivative · entry 5

FLIER JEFFREY S. · CIK 0001740266 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 20,316 shares

Expires 2028-06-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2025.

F9 · derivative.exercise_date: No shares remain unvested under this stock option.

SEC source: 0001415889-25-018187 · form4-06252025_040601.xml · nonDerivative · entry 4

FLIER JEFFREY S. · CIK 0001740266 · Director

10b5-1 filing: Plan reported

Ownership: Indirect · By trust

Disclosed balance after: 11,136

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2025.

F7 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $32.830 to $33.790, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F8 · ownership.nature: Represents shares owned directly by The Jeffrey S. Flier Family Trust - 2014, for which the Reporting Person's spouse, Eleftheria Maratos-Flier, and Samuel C. Sichko are trustees. The Reporting Person disclaims Section 16 beneficial ownership of these securities, and this report shall not be deemed an admission that the Reporting Person is the beneficial owner of such securities for Section 16 or any other purpose.

SEC source: 0001415889-25-018187 · form4-06252025_040601.xml · nonDerivative · entry 3

FLIER JEFFREY S. · CIK 0001740266 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,070

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2025.

F5 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $32.640 to $32.830, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F6 · balance_after: Consists of 16,438 shares of common stock and 7,632 RSUs.

SEC source: 0001415889-25-018187 · form4-06252025_040601.xml · nonDerivative · entry 2

FLIER JEFFREY S. · CIK 0001740266 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,836

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2025.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $31.645 to $32.609, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F4 · balance_after: Consists of 19,204 shares of common stock and 7,632 RSUs.

SEC source: 0001415889-25-018187 · form4-06252025_040601.xml · nonDerivative · entry 1

FLIER JEFFREY S. · CIK 0001740266 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 44,386

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2025.

F2 · balance_after: Consists of 36,754 shares of common stock and 7,632 restricted stock units (RSUs).

SEC source: 0001415889-25-017540 · form4-06172025_040613.xml · nonDerivative · entry 2

Peng Katie · CIK 0001983850 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 34,920

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted on November 20, 2024 to cover tax obligations upon the vesting and settlement of restricted stock units ("RSUs").

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $32.43 to $32.78, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F5 · balance_after: Consists of 12,385 shares of common stock and 22,535 RSUs.

SEC source: 0001415889-25-017540 · form4-06172025_040613.xml · nonDerivative · entry 1

Peng Katie · CIK 0001983850 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 34,974

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted on November 20, 2024 to cover tax obligations upon the vesting and settlement of restricted stock units ("RSUs").

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $31.44 to $32.41, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F3 · balance_after: Consists of 12,439 shares of common stock and 22,535 RSUs.

SEC source: 0001415889-25-017538 · form4-06172025_040608.xml · nonDerivative · entry 1

Parlavecchio Caryn · CIK 0001922346 · CHRO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 157,642

F1 · shares: Represents the number of shares required to be sold by the Reporting Person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSUs") on June 15, 2025. This sale is mandated by the Issuer's election under its equity incentive plans to require the Reporting Person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the Reporting Person. The shares vested pursuant to awards that were granted on June 16, 2022. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards are fully vested.

F2 · balance_after: Consists of 64,200 shares of common stock and 93,442 RSUs.

SEC source: 0001415889-25-017539 · form4-06172025_040610.xml · nonDerivative · entry 1

Qatanani Mo · CIK 0001980298 · CHIEF SCIENTIFIC OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 139,561

F1 · shares: Represents the number of shares required to be sold by the Reporting Person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSUs") on June 15, 2025. This sale is mandated by the Issuer's election under its equity incentive plans to require the Reporting Person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the Reporting Person. The shares vested pursuant to awards that were granted on June 16, 2022. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards are fully vested.

F2 · balance_after: Consists of 24,066 shares of common stock and 115,495 RSUs.

SEC source: 0001415889-25-017537 · form4-06172025_040606.xml · nonDerivative · entry 1

Ho Junlin · CIK 0001868114 · GENERAL COUNSEL

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 222,569

F1 · shares: Represents the number of shares required to be sold by the Reporting Person to cover the tax withholding obligation in connection with the vesting of restricted stock units ("RSUs") on June 15, 2025. This sale is mandated by the Issuer's election under its equity incentive plans to require the Reporting Person to fund this tax withholding obligation by completing a "sell to cover" transaction with a brokerage firm designated by the Issuer. This sale does not represent a discretionary trade by the Reporting Person. The shares vested pursuant to awards that were granted on June 16, 2022. Each RSU represents the contingent right to receive upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to these RSU awards are fully vested.

F2 · balance_after: Consists of 105,648 shares of common stock and 116,921 RSUs.

SEC source: 0001415889-25-016671 · form4-06112025_040601.xml · derivative · entry 2

Ho Junlin · CIK 0001868114 · GENERAL COUNSEL

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,429

Underlying: Common Stock · 11,429 shares

Expires 2035-06-09

F3 · derivative.exercise_date: Options to vest in sixteen quarterly installments over four years, with the first quarterly installment to vest on August 12, 2025 and each additional installment to vest quarterly thereafter; provided the individual continues to have a service relationship with the Issuer on such vesting date.

SEC source: 0001415889-25-016671 · form4-06112025_040601.xml · nonDerivative · entry 1

Ho Junlin · CIK 0001868114 · GENERAL COUNSEL

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 230,011

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to the RSU vest in four annual installments over four years, with the first annual installment to vest on May 15, 2026 and each additional installment to vest annually thereafter, provided the reporting person continues to have a service relationship with the Issuer on such vesting date.

F2 · balance_after: Consists of 97,923 shares of common stock and 132,088 RSUs.

SEC source: 0001415889-25-015002 · form4-05302025_040506.xml · nonDerivative · entry 2

Reed Joshua · CIK 0001746541 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,732

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2025 to cover tax withholding obligations upon the vesting and settlement of RSUs.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $29.990 to $30.098, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F5 · balance_after: Consists of 8,100 shares of common stock and 7,632 RSUs.

SEC source: 0001415889-25-015002 · form4-05302025_040506.xml · nonDerivative · entry 1

Reed Joshua · CIK 0001746541 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 16,232

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2025 to cover tax withholding obligations upon the vesting and settlement of RSUs.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $28.995 to $29.970, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F3 · balance_after: Consists of 8,600 shares of common stock and 7,632 RSUs.

SEC source: 0001415889-25-015006 · form4-05302025_040514.xml · nonDerivative · entry 2

FLIER JEFFREY S. · CIK 0001740266 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,070

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2025 to cover tax withholding obligations upon the vesting and settlement of RSUs.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $29.59 to $30.12, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F5 · balance_after: Consists of 16,438 shares of common stock and 7,632 RSUs.

SEC source: 0001415889-25-015006 · form4-05302025_040514.xml · nonDerivative · entry 1

FLIER JEFFREY S. · CIK 0001740266 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 29,045

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2025 to cover tax withholding obligations upon the vesting and settlement of RSUs.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $28.55 to $29.49, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F3 · balance_after: Consists of 21,413 shares of common stock and 7,632 RSUs.

SEC source: 0001415889-25-015005 · form4-05302025_040512.xml · nonDerivative · entry 2

Burow Kristina · CIK 0001569248 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 21,071

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2025 to cover tax withholding obligations upon the vesting and settlement of RSUs.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $29.59 to $30.18, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F5 · balance_after: Consists of 13,439 shares of common stock and 7,632 RSUs.

SEC source: 0001415889-25-015005 · form4-05302025_040512.xml · nonDerivative · entry 1

Burow Kristina · CIK 0001569248 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,471

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2025 to cover tax withholding obligations upon the vesting and settlement of RSUs.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $28.57 to $29.49, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F3 · balance_after: Consists of 17,839 shares of common stock and 7,632 RSUs.

SEC source: 0001415889-25-015004 · form4-05302025_040510.xml · nonDerivative · entry 2

Gilman Michael · CIK 0001291144 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 55,216

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2025 to cover tax withholding obligations upon the vesting and settlement of RSUs.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $29.55 to $30.210, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F5 · balance_after: Consists of 47,584 shares of common stock and 7,632 RSUs.

SEC source: 0001415889-25-015004 · form4-05302025_040510.xml · nonDerivative · entry 1

Gilman Michael · CIK 0001291144 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 57,961

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2025 to cover tax withholding obligations upon the vesting and settlement of RSUs.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $28.55 to $29.54, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F3 · balance_after: Consists of 50,329 shares of common stock and 7,632 RSUs.

SEC source: 0001415889-25-015003 · form4-05302025_040508.xml · nonDerivative · entry 2

Brudnick Richard · CIK 0001692359 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,057

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2025 to cover tax withholding obligations upon the vesting and settlement of RSUs.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $29.91 to $30.10, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F5 · balance_after: Consists of 7,425 shares of common stock and 7,632 RSUs.

SEC source: 0001415889-25-015003 · form4-05302025_040508.xml · nonDerivative · entry 1

Brudnick Richard · CIK 0001692359 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 16,457

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2025 to cover tax withholding obligations upon the vesting and settlement of RSUs.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $28.90 to $29.89, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F3 · balance_after: Consists of 8,825 shares of common stock and 7,632 RSUs.

SEC source: 0001415889-25-015001 · form4-05302025_040504.xml · nonDerivative · entry 2

Vaishnaw Akshay · CIK 0001458494 · Director · President of R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 616,205

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2025 to cover tax withholding obligations upon the vesting and settlement of RSUs..

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $29.92 to $30.19, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F5 · balance_after: Consists of 16,205 shares of common stock and 100,000 RSUs and 500,000 PSUs. The amount of PSUs reported herein represents the maximum number of shares of the Issuer's common stock that may be issued.

SEC source: 0001415889-25-015001 · form4-05302025_040504.xml · nonDerivative · entry 1

Vaishnaw Akshay · CIK 0001458494 · Director · President of R&D

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 617,825

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted on February 27, 2025 to cover tax withholding obligations upon the vesting and settlement of RSUs..

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $28.92 to $29.81, inclusive. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F3 · balance_after: Consists of 17,825 shares of common stock and 100,000 RSUs and 500,000 Performance Stock Units (PSUs). The amount of PSUs reported herein represents the maximum number of shares of the Issuer's common stock that may be issued.

SEC source: 0001104659-25-052472 · tm2516084-3_4seq1.xml · derivative · entry 2

Peng Katie · CIK 0001983850 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,206

Underlying: Common Stock · 9,206 shares

Expires 2035-05-22

F3 · derivative.exercise_date: Options to vest and become fully exercisable on the earlier of the first anniversary following the date of grant or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

SEC source: 0001104659-25-052472 · tm2516084-3_4seq1.xml · nonDerivative · entry 1

Peng Katie · CIK 0001983850 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,951

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest on the earlier of June 15, 2026 or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

F2 · balance_after: Consists of 14,671 shares of Common Stock and 23,280 RSUs.

SEC source: 0001104659-25-052482 · tm2516084-6_4seq1.xml · derivative · entry 2

Reed Joshua · CIK 0001746541 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,206

Underlying: Common Stock · 9,206 shares

Expires 2035-05-22

F3 · derivative.exercise_date: Options to vest and become fully exercisable on the earlier of the first anniversary following the date of grant or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

SEC source: 0001104659-25-052482 · tm2516084-6_4seq1.xml · nonDerivative · entry 1

Reed Joshua · CIK 0001746541 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,132

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest on the earlier of June 15, 2026 or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

F2 · balance_after: Consists of 13,500 shares of Common Stock and 7,632 RSUs.

SEC source: 0001104659-25-052483 · tm2516084-7_4seq1.xml · derivative · entry 2

Brudnick Richard · CIK 0001692359 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,206

Underlying: Common Stock · 9,206 shares

Expires 2035-05-22

F3 · derivative.exercise_date: Options to vest and become fully exercisable on the earlier of the first anniversary following the date of grant or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

SEC source: 0001104659-25-052483 · tm2516084-7_4seq1.xml · nonDerivative · entry 1

Brudnick Richard · CIK 0001692359 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,132

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest on the earlier of June 15, 2026 or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

F2 · balance_after: Consists of 13,500 shares of Common Stock and 7,632 RSUs.

SEC source: 0001104659-25-052479 · tm2516084-5_4seq1.xml · derivative · entry 3

Burow Kristina · CIK 0001569248 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,206

Underlying: Common Stock · 9,206 shares

Expires 2035-05-22

F5 · derivative.exercise_date: Options to vest and become fully exercisable on the earlier of the first anniversary following the date of grant or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

SEC source: 0001104659-25-052479 · tm2516084-5_4seq1.xml · nonDerivative · entry 1

Burow Kristina · CIK 0001569248 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,471

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest on the earlier of June 15, 2026 or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

F2 · balance_after: Consists of 18,839 shares of Common Stock and 7,632 RSUs.

SEC source: 0001104659-25-052478 · tm2516084-4_4seq1.xml · derivative · entry 3

AKKARAJU SRINIVAS · CIK 0001253170 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,206

Underlying: Common Stock · 9,206 shares

Expires 2035-05-22

F4 · derivative.exercise_date: Options to vest and become fully exercisable on the earlier of the first anniversary following the date of grant or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

SEC source: 0001104659-25-052478 · tm2516084-4_4seq1.xml · nonDerivative · entry 1

AKKARAJU SRINIVAS · CIK 0001253170 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,132

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU vest on the earlier of June 15, 2026 or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.

F2 · balance_after: Consists of 13,500 shares of Common Stock and 7,632 RSUs.

SEC source: 0001104659-25-052471 · tm2516084-2_4seq1.xml · derivative · entry 2

Gilman Michael · CIK 0001291144 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,206

Underlying: Common Stock · 9,206 shares

Expires 2035-05-22

F3 · derivative.exercise_date: Options to vest and become fully exercisable on the earlier of the first anniversary following the date of grant or on the date of the Issuer's next Annual Meeting subject to continued service to the Issuer through such date.