SRRK

SEC source: 0001104659-21-139527 · tm2133015-1_4seq1.xml · nonDerivative · entry 4

Myles Edward H · CIK 0001358219 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,150

F1 · shares: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F7 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $35.00 to $35.62. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F3 · balance_after: Consists of 24,150 RSUs.

SEC source: 0001104659-21-139527 · tm2133015-1_4seq1.xml · nonDerivative · entry 3

Myles Edward H · CIK 0001358219 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 73,998

F1 · shares: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F5 · price: The shares of common stock were acquired at a price per share of $13.83, $20.52 and $21.21 as reported in Table II.

F6 · balance_after: Consists of 49,848 shares of common stock and 24,150 RSUs. Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU award will vest annually over four years, subject to a continued service relationship with the Issuer on such vesting date.

SEC source: 0001104659-21-139527 · tm2133015-1_4seq1.xml · derivative · entry 9

Myles Edward H · CIK 0001358219 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 242,227

Underlying: Common Stock · 7,773 shares

Expires 2030-07-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · derivative.exercise_date: Shares vest over four years, with 25% vesting on July 16, 2021, and the remainder of shares vesting in twelve (12) quarterly installments thereafter, subject to such individual's continued service relationship with the Issuer through each such date.

SEC source: 0001104659-21-139527 · tm2133015-1_4seq1.xml · derivative · entry 8

Myles Edward H · CIK 0001358219 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 5,079 shares

Expires 2029-05-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-21-139527 · tm2133015-1_4seq1.xml · derivative · entry 7

Myles Edward H · CIK 0001358219 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 10,722 shares

Expires 2028-11-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-21-139527 · tm2133015-1_4seq1.xml · nonDerivative · entry 2

Myles Edward H · CIK 0001358219 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,150

F1 · shares: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $35.00 to $35.71. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F3 · balance_after: Consists of 24,150 RSUs.

SEC source: 0001104659-21-139527 · tm2133015-1_4seq1.xml · nonDerivative · entry 1

Myles Edward H · CIK 0001358219 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,724

F1 · shares: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F5 · price: The shares of common stock were acquired at a price per share of $13.83, $20.52 and $21.21 as reported in Table II.

F2 · balance_after: Consists of 23,574 shares of common stock and 24,150 restricted stock units ("RSU"). Each RSU represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU award will vest annually over four years, subject to a continued service relationship with the Issuer on such vesting date.

SEC source: 0001104659-21-122816 · tm2129100-1_4seq1.xml · nonDerivative · entry 1

FLIER JEFFREY S. · CIK 0001740266 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By The Jeffrey S. Flier Family Trust - 2014

Disclosed balance after: 22,272

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $30.11 to $33.135. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F2 · ownership.nature: These shares are owned directly by The Jeffrey S. Flier Family Trust - 2014, for which the reporting person's spouse, Eleftheria Maratos-Flier, and Samuel C. Sichko are trustees. The reporting person disclaims Section 16 beneficial ownership of these securities, and this report shall not be deemed an admission that the reporting person is the beneficial owner of such securities for Section 16 or any other purpose.

SEC source: 0001104659-21-117923 · tm2128074-1_4seq1.xml · nonDerivative · entry 1

FLIER JEFFREY S. · CIK 0001740266 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,013

F1 · shares: The reporting person contributed shares to a Donor Advised Fund. The shares were valued at the closing price on September 20, 2021 of $34.09 per share.

F1 · price: The reporting person contributed shares to a Donor Advised Fund. The shares were valued at the closing price on September 20, 2021 of $34.09 per share.

SEC source: 0001179110-21-007697 · edgar.xml · nonDerivative · entry 2

FLIER JEFFREY S. · CIK 0001740266 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By The Jeffrey S. Flier Family Trust - 2014

Disclosed balance after: 28,272

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F4 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $31.26 to $31.65. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F2 · ownership.nature: These shares are owned directly by The Jeffrey S. Flier Family Trust - 2014, for which the reporting person's spouse, Eleftheria Maratos-Flier, and Samuel C. Sichko are trustees. The reporting person disclaims Section 16 beneficial ownership of these securities, and this report shall not be deemed an admission that the reporting person is the beneficial owner of such securities for Section 16 or any other purpose.

SEC source: 0001179110-21-007697 · edgar.xml · nonDerivative · entry 1

FLIER JEFFREY S. · CIK 0001740266 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By The Jeffrey S. Flier Family Trust - 2014

Disclosed balance after: 31,309

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $31.66 to $32.65. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F2 · ownership.nature: These shares are owned directly by The Jeffrey S. Flier Family Trust - 2014, for which the reporting person's spouse, Eleftheria Maratos-Flier, and Samuel C. Sichko are trustees. The reporting person disclaims Section 16 beneficial ownership of these securities, and this report shall not be deemed an admission that the reporting person is the beneficial owner of such securities for Section 16 or any other purpose.

SEC source: 0001179110-21-006158 · edgar.xml · derivative · entry 1

Burow Kristina · CIK 0001569248 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,800

Underlying: Common Stock · 7,800 shares

Expires 2031-05-27

F1 · derivative.exercise_date: This option shall vest and become fully exercisable on the earlier of the first anniversary following the date of grant of the next scheduled Annual Meeting.

SEC source: 0001179110-21-006147 · edgar.xml · derivative · entry 1

Hallal David · CIK 0001457477 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,800

Underlying: Common Stock · 7,800 shares

Expires 2031-05-27

F1 · derivative.exercise_date: This option shall vest and become fully exercisable on the earlier of the first anniversary following the date of grant or the next scheduled Annual Meeting.

SEC source: 0001179110-21-006144 · edgar.xml · derivative · entry 1

FLIER JEFFREY S. · CIK 0001740266 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,800

Underlying: Common Stock · 7,800 shares

Expires 2031-05-27

F1 · derivative.exercise_date: This option shall vest and become fully exercisable on the earlier of the first anniversary following the date of grant or the next scheduled Annual Meeting.

SEC source: 0001179110-21-006142 · edgar.xml · derivative · entry 1

Gilman Michael · CIK 0001291144 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,800

Underlying: Common Stock · 7,800 shares

Expires 2031-05-27

F1 · derivative.exercise_date: This option shall vest and become fully exercisable on the earlier of the first anniversary following the date of grant or the next scheduled Annual Meeting.

SEC source: 0001179110-21-006140 · edgar.xml · derivative · entry 1

Nashat Amir · CIK 0001575843 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,800

Underlying: Common Stock · 7,800 shares

Expires 2031-05-27

F1 · derivative.exercise_date: This option shall vest and become fully exercisable on the earlier of the first anniversary following the date of grant or the next scheduled Annual Meeting.

SEC source: 0001179110-21-006138 · edgar.xml · derivative · entry 1

Vaishnaw Akshay · CIK 0001458494 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,800

Underlying: Common Stock · 7,800 shares

Expires 2031-05-27

F1 · derivative.exercise_date: This option shall vest and become fully exercisable on the earlier of the first anniversary following the date of grant or the next scheduled Annual Meeting.

SEC source: 0001179110-21-003595 · edgar.xml · derivative · entry 1

Reed Joshua · CIK 0001746541 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,600

Underlying: Common Sotck · 15,600 shares

Expires 2031-03-16

F1 · derivative.exercise_date: This option vests monthly over three (3) years, with the first monthly amount vesting on April 18, 2021, provided Mr. Reed continues to serve on the Board on such vesting date.

SEC source: 0001179110-21-003552 · edgar.xml · nonDerivative · entry 1

Gilman Michael · CIK 0001291144 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,459

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $65.20 to $66.00. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0001179110-21-001568 · edgar.xml · nonDerivative · entry 1

Gilman Michael · CIK 0001291144 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,155

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $65.00 to $65.73. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0001179110-21-001255 · edgar.xml · derivative · entry 2

Carven Gregory John · CIK 0001815432 · Head of Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 177,631

Underlying: Common Stock · 42,000 shares

Expires 2031-02-01

F2 · derivative.exercise_date: Shares will vest and become exercisable quarterly over four years, subject to a continued service relationship with the Issuer on such vesting date.

SEC source: 0001179110-21-001255 · edgar.xml · nonDerivative · entry 1

Carven Gregory John · CIK 0001815432 · Head of Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,600

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU award will vest and become exercisable quarterly over four years, subject to a continued service relationship with the Issuer on such vesting date.

SEC source: 0001179110-21-001253 · edgar.xml · derivative · entry 2

CHYUNG YUNG H. · CIK 0001740377 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 225,534

Underlying: Common Stock · 52,500 shares

Expires 2031-02-01

F2 · derivative.exercise_date: Shares will vest and become exercisable quarterly over four years, subject to a continued service relationship with the Issuer on such vesting date.

SEC source: 0001179110-21-001253 · edgar.xml · nonDerivative · entry 1

CHYUNG YUNG H. · CIK 0001740377 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,750

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU award will vest and become exercisable quarterly over four years, subject to a continued service relationship with the Issuer on such vesting date.

SEC source: 0001179110-21-001251 · edgar.xml · derivative · entry 2

Myles Edward H · CIK 0001358219 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 346,301

Underlying: Common Stock · 80,500 shares

Expires 2031-02-01

F2 · derivative.exercise_date: Shares will vest and become exercisable quarterly over four years, subject to a continued service relationship with the Issuer on such vesting date.

SEC source: 0001179110-21-001251 · edgar.xml · nonDerivative · entry 1

Myles Edward H · CIK 0001358219 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,150

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU award will vest and become exercisable quarterly over four years, subject to a continued service relationship with the Issuer on such vesting date.

SEC source: 0001179110-21-001250 · edgar.xml · derivative · entry 2

Kingsley Stuart A · CIK 0001369067 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 590,000

Underlying: Common Stock · 140,000 shares

Expires 2031-02-01

F2 · derivative.exercise_date: Shares will vest and become exercisable quarterly over four years, subject to a continued service relationship with the Issuer on such vesting date.

SEC source: 0001179110-21-001250 · edgar.xml · nonDerivative · entry 1

Kingsley Stuart A · CIK 0001369067 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,000

F1 · shares: Each restricted stock unit ("RSU") represents the contingent right to receive, upon vesting of the RSU, one share of the Issuer's common stock. The shares subject to this RSU award will vest and become exercisable annually over four years, subject to a continued service relationship with the Issuer on such vesting date.

SEC source: 0001179110-21-000925 · edgar.xml · nonDerivative · entry 5

Carven Gregory John · CIK 0001815432 · Head of Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,734

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F8 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $57.39 to $58.28. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F4 · balance_after: The original Form 4, filed on January 28, 2021, is being amended by this Form 4 amendment solely to correct an administrative error, which misreported a sale that occurred on January 26, 2021, as a total of 8,417 shares sold when in fact 2,543 shares of the Issuer's common stock were sold. As a result of this administrative error, the number of shares beneficially owned by the reporting person following the corrected transaction reflects an increase in the number of shares reported as beneficially owned by the reporting person by 5,874 shares.

SEC source: 0001179110-21-000925 · edgar.xml · nonDerivative · entry 4

Carven Gregory John · CIK 0001815432 · Head of Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,295

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F7 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $56.31 to $57.17. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F4 · balance_after: The original Form 4, filed on January 28, 2021, is being amended by this Form 4 amendment solely to correct an administrative error, which misreported a sale that occurred on January 26, 2021, as a total of 8,417 shares sold when in fact 2,543 shares of the Issuer's common stock were sold. As a result of this administrative error, the number of shares beneficially owned by the reporting person following the corrected transaction reflects an increase in the number of shares reported as beneficially owned by the reporting person by 5,874 shares.

SEC source: 0001179110-21-000925 · edgar.xml · nonDerivative · entry 3

Carven Gregory John · CIK 0001815432 · Head of Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,434

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F6 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $61.35 to $61.89. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F4 · balance_after: The original Form 4, filed on January 28, 2021, is being amended by this Form 4 amendment solely to correct an administrative error, which misreported a sale that occurred on January 26, 2021, as a total of 8,417 shares sold when in fact 2,543 shares of the Issuer's common stock were sold. As a result of this administrative error, the number of shares beneficially owned by the reporting person following the corrected transaction reflects an increase in the number of shares reported as beneficially owned by the reporting person by 5,874 shares.

SEC source: 0001179110-21-000896 · edgar.xml · derivative · entry 16

Carven Gregory John · CIK 0001815432 · Head of Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,316

Underlying: Common Stock · 6,619 shares

Expires 2029-01-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F3 · derivative.exercise_date: This option vests quarterly over four (4) years on a quarterly basis through December 31, 2022.

SEC source: 0001179110-21-000896 · edgar.xml · nonDerivative · entry 12

Carven Gregory John · CIK 0001815432 · Head of Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,860

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F12 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $57.39 to $58.28. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0001179110-21-000896 · edgar.xml · nonDerivative · entry 11

Carven Gregory John · CIK 0001815432 · Head of Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,421

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F11 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $56.31 to $57.17. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0001179110-21-000896 · edgar.xml · nonDerivative · entry 10

Carven Gregory John · CIK 0001815432 · Head of Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,560

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F10 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $55.30 to $56.29. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0001179110-21-000896 · edgar.xml · nonDerivative · entry 4

Carven Gregory John · CIK 0001815432 · Head of Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 82,734

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

SEC source: 0001179110-21-000925 · edgar.xml · nonDerivative · entry 2

Carven Gregory John · CIK 0001815432 · Head of Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 51,834

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F5 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $61.35 to $61.89. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F4 · balance_after: The original Form 4, filed on January 28, 2021, is being amended by this Form 4 amendment solely to correct an administrative error, which misreported a sale that occurred on January 26, 2021, as a total of 8,417 shares sold when in fact 2,543 shares of the Issuer's common stock were sold. As a result of this administrative error, the number of shares beneficially owned by the reporting person following the corrected transaction reflects an increase in the number of shares reported as beneficially owned by the reporting person by 5,874 shares.

SEC source: 0001179110-21-000925 · edgar.xml · nonDerivative · entry 1

Carven Gregory John · CIK 0001815432 · Head of Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,898

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F3 · shares: The original Form 4, filed on January 28, 2021, is being amended by this Form 4 amendment solely to correct an administrative error, which misreported a sale that occurred on January 26, 2021, as a total of 8,417 shares sold when in fact 2,543 shares of the Issuer's common stock were sold. As a result of this administrative error, the number of shares sold by the reporting person following the corrected transaction reflects a decrease in the number of shares reported as sold by the reporting person by 5,874 shares.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $60.28 to $61.25. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

F4 · balance_after: The original Form 4, filed on January 28, 2021, is being amended by this Form 4 amendment solely to correct an administrative error, which misreported a sale that occurred on January 26, 2021, as a total of 8,417 shares sold when in fact 2,543 shares of the Issuer's common stock were sold. As a result of this administrative error, the number of shares beneficially owned by the reporting person following the corrected transaction reflects an increase in the number of shares reported as beneficially owned by the reporting person by 5,874 shares.

SEC source: 0001179110-21-000896 · edgar.xml · derivative · entry 15

Carven Gregory John · CIK 0001815432 · Head of Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,283

Underlying: Common Stock · 20,000 shares

Expires 2028-02-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F4 · derivative.exercise_date: This option vests quarterly over four (4) years through February 13, 2022.

SEC source: 0001179110-21-000896 · edgar.xml · derivative · entry 14

Carven Gregory John · CIK 0001815432 · Head of Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,935

Underlying: Common Stock · 5,245 shares

Expires 2029-01-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F3 · derivative.exercise_date: This option vests quarterly over four (4) years on a quarterly basis through December 31, 2022.

SEC source: 0001179110-21-000896 · edgar.xml · derivative · entry 13

Carven Gregory John · CIK 0001815432 · Head of Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,399

Underlying: Common Stock · 5,655 shares

Expires 2028-05-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F2 · derivative.exercise_date: This option vests quarterly over four (4) years on a quarterly basis through May 29, 2022.

SEC source: 0001179110-21-000896 · edgar.xml · nonDerivative · entry 9

Carven Gregory John · CIK 0001815432 · Head of Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,960

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F9 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $61.35 to $61.89. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0001179110-21-000896 · edgar.xml · nonDerivative · entry 8

Carven Gregory John · CIK 0001815432 · Head of Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,024

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F8 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $60.28 to $61.25. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0001179110-21-000896 · edgar.xml · nonDerivative · entry 7

Carven Gregory John · CIK 0001815432 · Head of Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 55,441

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F7 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $59.26 to $60.25. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0001179110-21-000896 · edgar.xml · nonDerivative · entry 6

Carven Gregory John · CIK 0001815432 · Head of Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 64,690

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F6 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $58.28 to $59.26. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0001179110-21-000896 · edgar.xml · nonDerivative · entry 5

Carven Gregory John · CIK 0001815432 · Head of Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 78,058

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

F5 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $57.28 to $58.26. Full information regarding the number of shares sold at each separate price can be furnished to the SEC staff upon request.

SEC source: 0001179110-21-000896 · edgar.xml · nonDerivative · entry 3

Carven Gregory John · CIK 0001815432 · Head of Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 76,115

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

SEC source: 0001179110-21-000896 · edgar.xml · nonDerivative · entry 2

Carven Gregory John · CIK 0001815432 · Head of Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,115

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

SEC source: 0001179110-21-000896 · edgar.xml · nonDerivative · entry 1

Carven Gregory John · CIK 0001815432 · Head of Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,870

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.

SEC source: 0001179110-21-000897 · edgar.xml · derivative · entry 7

Gilman Michael · CIK 0001291144 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,313 shares

Expires 2028-02-20

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a trading plan intended to comply with Rule 10b5-1 of the Securities Exchange Act of 1934.