SPRY

SEC source: 0001209191-23-044845 · doc4.xml · derivative · entry 6

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,997

Underlying: Common Stock · 18,897 shares

Expires 2030-04-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: Immediately exercisable.

SEC source: 0001209191-23-044845 · doc4.xml · nonDerivative · entry 4

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 210,346

F1 · kind: The sales reported on this Form 4 were sold pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 15, 2022.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $6.96 to $7.22, inclusive. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each price within the range set forth herein.

SEC source: 0001209191-23-044845 · doc4.xml · nonDerivative · entry 3

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 229,243

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-044845 · doc4.xml · derivative · entry 5

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 21,894

Underlying: Common Stock · 26,107 shares

Expires 2030-04-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: Immediately exercisable.

SEC source: 0001209191-23-044845 · doc4.xml · nonDerivative · entry 2

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 210,346

F1 · kind: The sales reported on this Form 4 were sold pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 15, 2022.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $6.90 to $7.10, inclusive. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each price within the range set forth herein.

SEC source: 0001209191-23-044845 · doc4.xml · nonDerivative · entry 1

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 236,453

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-044534 · doc4.xml · derivative · entry 6

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 48,001

Underlying: Common Stock · 36,281 shares

Expires 2030-04-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: Immediately exercisable.

SEC source: 0001209191-23-044534 · doc4.xml · nonDerivative · entry 4

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 210,346

F1 · kind: The sales reported on this Form 4 were sold pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 15, 2022.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $6.95 to $7.23, inclusive. The Reporting Person undertakes to provide the the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each price within the range set forth herein.

SEC source: 0001209191-23-044534 · doc4.xml · nonDerivative · entry 3

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 246,627

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-044534 · doc4.xml · derivative · entry 5

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 84,282

Underlying: Common Stock · 18,715 shares

Expires 2030-04-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: Immediately exercisable.

SEC source: 0001209191-23-044534 · doc4.xml · nonDerivative · entry 2

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 210,346

F1 · kind: The sales reported on this Form 4 were sold pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 15, 2022.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $7.11 to $7.33, inclusive. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each price within the range set forth herein.

SEC source: 0001209191-23-044534 · doc4.xml · nonDerivative · entry 1

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 229,061

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-041866 · doc4.xml · derivative · entry 3

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 102,997

Underlying: Common Stock · 8,858 shares

Expires 2030-04-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Immediately exercisable.

SEC source: 0001209191-23-041866 · doc4.xml · nonDerivative · entry 2

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 210,346

F1 · kind: The sales reported on this Form 4 were sold pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 15, 2022.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $6.21 to $6.56, inclusive. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each price within the range set forth herein.

SEC source: 0001209191-23-041866 · doc4.xml · nonDerivative · entry 1

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 219,204

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-041716 · doc4.xml · derivative · entry 9

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 111,855

Underlying: Common Stock · 33,510 shares

Expires 2030-04-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: Immediately exercisable.

SEC source: 0001209191-23-041716 · doc4.xml · nonDerivative · entry 6

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 210,346

F1 · kind: The sales reported on this Form 4 were sold pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 15, 2022.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $6.10 to $6.45, inclusive. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each price within the range set forth herein.

SEC source: 0001209191-23-041716 · doc4.xml · nonDerivative · entry 5

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 243,856

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-041716 · doc4.xml · derivative · entry 8

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 145,365

Underlying: Common Stock · 31,112 shares

Expires 2030-04-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: Immediately exercisable.

SEC source: 0001209191-23-041716 · doc4.xml · nonDerivative · entry 4

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 210,346

F1 · kind: The sales reported on this Form 4 were sold pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 15, 2022.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $6.21 to $6.75, inclusive. The Reporting Person undertakes to provide the the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each price within the range set forth herein.

SEC source: 0001209191-23-041716 · doc4.xml · nonDerivative · entry 3

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 241,458

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-041716 · doc4.xml · derivative · entry 7

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 176,477

Underlying: Common Stock · 26,520 shares

Expires 2030-04-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: Immediately exercisable.

SEC source: 0001209191-23-041716 · doc4.xml · nonDerivative · entry 2

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 210,346

F1 · kind: The sales reported on this Form 4 were sold pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 15, 2022.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $6.62 to $6.81, inclusive. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each price within the range set forth herein.

SEC source: 0001209191-23-041716 · doc4.xml · nonDerivative · entry 1

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 236,866

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-040115 · doc4.xml · derivative · entry 1

Dadoo Rajeev · CIK 0001951685 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2033-06-26

F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of June 27, 2024 or the date of the Issuer's 2024 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors.

SEC source: 0001104659-23-075962 · tm2320008-1_4seq1.xml · derivative · entry 1

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director

RA Capital Healthcare Fund LP · CIK 0001315082 · Director

RA Capital Nexus Fund II, L.P. · CIK 0001825376 · Director

Kolchinsky Peter · CIK 0001384859 · Director

Shah Rajeev M. · CIK 0001619841 · Director

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnotes

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2033-06-26

F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of June 27, 2024 or the date of the Issuer's 2024 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors.

F1 · ownership.nature: The shares subject to the option will vest in full on the earlier of June 27, 2024 or the date of the Issuer's 2024 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors.

F2 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund") and RA Capital Nexus Fund II, L.P. (the "Nexus Fund II"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. The Adviser, the Adviser GP, Dr. Kolchinsky, and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein.

F3 · ownership.nature: Under Dr. Kolchinsky's arrangement with the Adviser, Dr. Kolchinsky holds the option for the benefit of the Fund and the Nexus Fund II. Dr. Kolchinsky is obligated to turn over to the Adviser any net cash or stock received upon exercise of the option, which will offset advisory fees owed by the Fund and the Nexus Fund II to the Adviser. The Reporting Persons therefore disclaim beneficial ownership of the option and underlying common stock except to the extent of their pecuniary interest.

SEC source: 0001209191-23-040113 · doc4.xml · derivative · entry 1

Kelly Michael · CIK 0001952533 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2033-06-26

F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of June 27, 2024 or the date of the Issuer's 2024 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors.

SEC source: 0001209191-23-040112 · doc4.xml · derivative · entry 1

Shah Pratik · CIK 0001580787 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2033-06-26

F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of June 27, 2024 or the date of the Issuer's 2024 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors.

SEC source: 0001209191-23-040111 · doc4.xml · derivative · entry 1

Thompson Peter A. · CIK 0001357522 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2033-06-26

F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of June 27, 2024 or the date of the Issuer's 2024 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors.

SEC source: 0001209191-23-040110 · doc4.xml · derivative · entry 1

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2033-06-26

F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of June 27, 2024 or the date of the Issuer's 2024 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors.

SEC source: 0001209191-23-040109 · doc4.xml · derivative · entry 1

SAUNDERS BRENT L · CIK 0001268854 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2033-06-26

F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of June 27, 2024 or the date of the Issuer's 2024 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors.

SEC source: 0001209191-23-040108 · doc4.xml · derivative · entry 1

SCHNEIDER PHILLIP M · CIK 0001230051 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2033-06-26

F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of June 27, 2024 or the date of the Issuer's 2024 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors.

SEC source: 0001209191-23-040107 · doc4.xml · derivative · entry 1

Islam Saqib · CIK 0001575408 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2033-06-26

F1 · derivative.exercise_date: The shares subject to the option will vest in full on the earlier of June 27, 2024 or the date of the Issuer's 2024 annual meeting of stockholders, which date has not been set by the Issuer's Board of Directors.

SEC source: 0001209191-23-034090 · doc4.xml · derivative · entry 6

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 202,997

Underlying: Common Stock · 26,941 shares

Expires 2030-04-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: Immediately exercisable.

SEC source: 0001209191-23-034090 · doc4.xml · nonDerivative · entry 4

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 210,346

F1 · kind: The sales reported on this Form 4 were sold pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 15, 2022.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $6.73 to $7.22, inclusive. The Reporting Person undertakes to provide the the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each price within the range set forth herein.

SEC source: 0001209191-23-034090 · doc4.xml · nonDerivative · entry 3

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 237,287

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-23-034090 · doc4.xml · derivative · entry 5

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 229,938

Underlying: Common Stock · 73,059 shares

Expires 2030-04-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: Immediately exercisable.

SEC source: 0001209191-23-034090 · doc4.xml · nonDerivative · entry 2

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 210,346

F1 · kind: The sales reported on this Form 4 were sold pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 15, 2022.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions ranging from $6.60 to $7.07, inclusive. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each price within the range set forth herein.

SEC source: 0001209191-23-034090 · doc4.xml · nonDerivative · entry 1

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 283,405

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001209191-24-000825 · doc4.xml · nonDerivative · entry 4

Lowenthal Richard E · CIK 0001378550 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Lowenthal-Tanimoto Family Trust U/A DTD 4/3/2006

Disclosed balance after: 2,100,000

F1 · ownership.nature: These shares are held in a trust for the benefit of the Reporting Person and his spouse. The Reporting Person and his spouse are trustees of the trust.

SEC source: 0001209191-24-000825 · doc4.xml · nonDerivative · entry 3

Lowenthal Richard E · CIK 0001378550 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By spouse

Disclosed balance after: 3,276,854

SEC source: 0001209191-24-000825 · doc4.xml · nonDerivative · entry 2

Lowenthal Richard E · CIK 0001378550 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Lowenthal-Tanimoto Family Trust U/A DTD 4/3/2006

Disclosed balance after: 1,050,000

F1 · ownership.nature: These shares are held in a trust for the benefit of the Reporting Person and his spouse. The Reporting Person and his spouse are trustees of the trust.

SEC source: 0001209191-24-000825 · doc4.xml · nonDerivative · entry 1

Lowenthal Richard E · CIK 0001378550 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,126,822

SEC source: 0001209191-24-000815 · doc4.xml · nonDerivative · entry 4

Tanimoto Sarina · CIK 0001951291 · Chief Medical Officer · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Lowenthal-Tanimoto Family Trust U/A DTD 4/3/2006

Disclosed balance after: 2,100,000

F1 · ownership.nature: These shares are held in a trust for the benefit of the Reporting Person and her spouse. The Reporting Person and her spouse are trustees of the trust.

SEC source: 0001209191-24-000815 · doc4.xml · nonDerivative · entry 3

Tanimoto Sarina · CIK 0001951291 · Chief Medical Officer · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By spouse

Disclosed balance after: 4,126,822

F2 · balance_after: The Form 4 filed November 10, 2022 inadvertently omitted 849,968 shares indirectly owned by the Reporting Person. The omitted shares are directly owned by the Reporting Person's spouse and were properly reported on his Form 4 filed November 10, 2022. The amount listed in Column 5 has been adjusted to reflect the correct holdings after giving effect to the May 17, 2023 gift transaction.

SEC source: 0001209191-24-000815 · doc4.xml · nonDerivative · entry 2

Tanimoto Sarina · CIK 0001951291 · Chief Medical Officer · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Lowenthal-Tanimoto Family Trust U/A DTD 4/3/2006

Disclosed balance after: 1,050,000

F1 · ownership.nature: These shares are held in a trust for the benefit of the Reporting Person and her spouse. The Reporting Person and her spouse are trustees of the trust.

SEC source: 0001209191-24-000815 · doc4.xml · nonDerivative · entry 1

Tanimoto Sarina · CIK 0001951291 · Chief Medical Officer · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,276,854

SEC source: 0001209191-23-028507 · doc4.xml · derivative · entry 7

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 302,997

Underlying: Common Stock · 42,900 shares

Expires 2030-04-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: Immediately exercisable.

SEC source: 0001209191-23-028507 · doc4.xml · nonDerivative · entry 5

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 210,346

F3 · kind: The sales reported on this Form 4 were sold pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 15, 2022.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions ranging from $5.00 to $5.92, inclusive. The Reporting Person undertakes to provide the the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each price within the range set forth herein.

SEC source: 0001209191-23-028507 · doc4.xml · nonDerivative · entry 4

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 253,246

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.