SOPH

SEC source: 0001840706-26-000263 · wk-form4_1784750500.xml · nonDerivative · entry 2

Camblong Jurgi · CIK 0002007050 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,517,403

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

SEC source: 0001840706-26-000263 · wk-form4_1784750500.xml · nonDerivative · entry 1

Camblong Jurgi · CIK 0002007050 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,512,822

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $6.30 to $6.37, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000261 · wk-form4_1784059371.xml · nonDerivative · entry 1

Menu Philippe · CIK 0002014308 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 228,387

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $5.55 to $5.79, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000260 · wk-form4_1784059366.xml · nonDerivative · entry 1

Xu Zhenyu · CIK 0002006362 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 610,887

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $5.54 to $5.79, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000259 · wk-form4_1784059360.xml · nonDerivative · entry 1

Camblong Jurgi · CIK 0002007050 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,532,622

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $5.53 to $5.77, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000255 · wk-form4_1783540881.xml · nonDerivative · entry 1

Camblong Jurgi · CIK 0002007050 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,541,122

F1 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on July 3, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

SEC source: 0001840706-26-000247 · wk-form4_1783454604.xml · nonDerivative · entry 1

Menu Philippe · CIK 0002014308 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 233,387

F1 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on July 2 and July 3, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $4.97 to $5.44, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000252 · wk-form4_1783454635.xml · nonDerivative · entry 1

Valente Manuela · CIK 0002009280 · Chief People Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 210,450

F1 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on July 2, 2026 and July 3, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $4.95 to $5.34, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000250 · wk-form4_1783454623.xml · nonDerivative · entry 1

Xu Zhenyu · CIK 0002006362 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 614,887

F1 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on July 2 and July 3, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $4.97 to $5.43, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000246 · wk-form4_1783454594.xml · nonDerivative · entry 1

Camblong Jurgi · CIK 0002007050 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,558,807

F1 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on July 2 and July 3, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $4.97 to $5.43, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000249 · wk-form4_1783454617.xml · nonDerivative · entry 1

Muken Ross · CIK 0002005463 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 670,651

F1 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on July 2 and July 3, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $4.97 to $5.43, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000253 · wk-form4_1783454641.xml · nonDerivative · entry 1

CARDOZA GEORGE · CIK 0001518734 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 309,092

F1 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on July 2, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $4.97 to $5.43, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000248 · wk-form4_1783454610.xml · nonDerivative · entry 3

Puylaert Kevin · CIK 0002119354 · Chief Sales Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 147,948

F2 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax obligations in connection with the vesting of restricted stock units on July 3, 2026. The sales were effected as a "sell to cover" transaction and do not represent discretionary trades.

SEC source: 0001840706-26-000248 · wk-form4_1783454610.xml · nonDerivative · entry 2

Puylaert Kevin · CIK 0002119354 · Chief Sales Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 147,979

F1 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax obligations in connection with the vesting of restricted stock units on July 2, 2026. The sales were effected as a "sell to cover" transaction and do not represent discretionary trades.

SEC source: 0001840706-26-000248 · wk-form4_1783454610.xml · nonDerivative · entry 1

Puylaert Kevin · CIK 0002119354 · Chief Sales Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 148,026

F1 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax obligations in connection with the vesting of restricted stock units on July 2, 2026. The sales were effected as a "sell to cover" transaction and do not represent discretionary trades.

SEC source: 0001840706-26-000251 · wk-form4_1783454629.xml · nonDerivative · entry 1

Verma Abhimanyu · CIK 0002114540 · Chief Technology Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 192,171

F1 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on July 2 and July 3, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $4.97 to $5.41, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000237 · wk-form4_1782936197.xml · derivative · entry 9

Camblong Jurgi · CIK 0002007050 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,581

Underlying: Ordinary Shares · 45,419 shares

Expires 2028-11-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F4 · derivative.exercise_date: The share options are fully vested and exercisable.

F6 · balance_after: Following the transaction reported on this line, the Reporting Person holds an aggregate total of 4,646,057 derivative stock options across all remaining grant tranches with varying exercise prices.

SEC source: 0001840706-26-000237 · wk-form4_1782936197.xml · nonDerivative · entry 7

Camblong Jurgi · CIK 0002007050 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,581,293

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

SEC source: 0001840706-26-000237 · wk-form4_1782936197.xml · nonDerivative · entry 6

Camblong Jurgi · CIK 0002007050 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,581,493

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $6.00 to $6.03, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000237 · wk-form4_1782936197.xml · nonDerivative · entry 5

Camblong Jurgi · CIK 0002007050 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,601,143

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $6.10 to $6.30, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000237 · wk-form4_1782936197.xml · nonDerivative · entry 4

Camblong Jurgi · CIK 0002007050 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,646,562

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

SEC source: 0001840706-26-000237 · wk-form4_1782936197.xml · derivative · entry 8

Camblong Jurgi · CIK 0002007050 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Ordinary Shares · 18,060 shares

Expires 2028-11-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F4 · derivative.exercise_date: The share options are fully vested and exercisable.

F5 · balance_after: Following the transaction reported on this line, the Reporting Person holds an aggregate total of 4,691,476 derivative stock options across all remaining grant tranches with varying exercise prices.

SEC source: 0001840706-26-000237 · wk-form4_1782936197.xml · nonDerivative · entry 3

Camblong Jurgi · CIK 0002007050 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,601,143

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

SEC source: 0001840706-26-000237 · wk-form4_1782936197.xml · nonDerivative · entry 2

Camblong Jurgi · CIK 0002007050 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,601,493

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

SEC source: 0001840706-26-000237 · wk-form4_1782936197.xml · nonDerivative · entry 1

Camblong Jurgi · CIK 0002007050 · Director · Executive Chairman

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,619,553

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

SEC source: 0001840706-26-000235 · wk-form4_1782763676.xml · derivative · entry 5

Camblong Jurgi · CIK 0002007050 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 68,060

Underlying: Ordinary Shares · 31,940 shares

Expires 2028-11-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The share options are fully vested and exercisable.

F5 · balance_after: Following the transaction reported on this line, the Reporting Person holds an aggregate total of 4,709,536 derivative stock options across all remaining grant tranches with varying exercise prices.

SEC source: 0001840706-26-000235 · wk-form4_1782763676.xml · nonDerivative · entry 4

Camblong Jurgi · CIK 0002007050 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,601,493

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F3 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $5.80 to $5.94, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000235 · wk-form4_1782763676.xml · nonDerivative · entry 3

Camblong Jurgi · CIK 0002007050 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,633,433

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

SEC source: 0001840706-26-000235 · wk-form4_1782763676.xml · nonDerivative · entry 2

Camblong Jurgi · CIK 0002007050 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,601,493

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $5.70 to $5.78, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000231 · wk-form4_1782504183.xml · nonDerivative · entry 1

Menu Philippe · CIK 0002014308 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 240,780

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $5.30 to $5.69, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000232 · wk-form4_1782504189.xml · nonDerivative · entry 1

Verma Abhimanyu · CIK 0002114540 · Chief Technology Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 197,456

F1 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $5.31 to $5.69, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000235 · wk-form4_1782763676.xml · nonDerivative · entry 1

Camblong Jurgi · CIK 0002007050 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,619,622

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

SEC source: 0001840706-26-000227 · wk-form4_1782244868.xml · nonDerivative · entry 1

Muken Ross · CIK 0002005463 · President

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 680,489

F1 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on June 18, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $5.33 to $5.48, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000228 · wk-form4_1782244876.xml · nonDerivative · entry 1

CARDOZA GEORGE · CIK 0001518734 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 310,684

F1 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on June 18, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $5.33 to $5.46, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000223 · wk-form4_1782158500.xml · derivative · entry 2

HIBBS KATHY L · CIK 0001267487 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 218,569

Underlying: Ordinary Shares · 28,818 shares

Expires 2036-06-18

F2 · derivative.exercise_date: The share options were granted on June 18, 2026 and vest 100% as of the date of the Issuer's next scheduled annual meeting of shareholders, subject to the Reporting Person's continued service to the Issuer through the relevant vesting date.

SEC source: 0001840706-26-000223 · wk-form4_1782158500.xml · nonDerivative · entry 1

HIBBS KATHY L · CIK 0001267487 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 109,492

F1 · shares: Represents a restricted stock unit ("RSU") grant. Each RSU represents a contingent right to receive one ordinary share of the Issuer, subject to Reporting Person's continued service with the Issuer. The RSUs were granted on June 18, 2026 and vest 100% as of the date of the Issuer's next scheduled annual meeting of shareholders.

SEC source: 0001840706-26-000220 · wk-form4_1782158478.xml · derivative · entry 2

HIRSCH DIDIER · CIK 0001226464 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 218,569

Underlying: Ordinary Shares · 28,818 shares

Expires 2036-06-18

F2 · derivative.exercise_date: The share options were granted on June 18, 2026 and vest 100% as of the date of the Issuer's next scheduled annual meeting of shareholders, subject to the Reporting Person's continued service to the Issuer through the relevant vesting date.

SEC source: 0001840706-26-000220 · wk-form4_1782158478.xml · nonDerivative · entry 1

HIRSCH DIDIER · CIK 0001226464 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 240,220

F1 · shares: Represents a restricted stock unit ("RSU") grant. Each RSU represents a contingent right to receive one ordinary share of the Issuer, subject to Reporting Person's continued service with the Issuer. The RSUs were granted on June 18, 2026 and vest 100% as of the date of the Issuer's next scheduled annual meeting of shareholders.

SEC source: 0001840706-26-000224 · wk-form4_1782158508.xml · derivative · entry 2

Cox Troy · CIK 0001696923 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 252,809

Underlying: Ordinary Shares · 28,818 shares

Expires 2036-06-18

F2 · derivative.exercise_date: The share options were granted on June 18, 2026 and vest 100% as of the date of the Issuer's next scheduled annual meeting of shareholders, subject to the Reporting Person's continued service to the Issuer through the relevant vesting date.

SEC source: 0001840706-26-000224 · wk-form4_1782158508.xml · nonDerivative · entry 1

Cox Troy · CIK 0001696923 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 328,743

F1 · shares: Represents a restricted stock unit ("RSU") grant. Each RSU represents a contingent right to receive one ordinary share of the Issuer, subject to Reporting Person's continued service with the Issuer. The RSUs were granted on June 18, 2026 and vest 100% as of the date of the Issuer's next scheduled annual meeting of shareholders.

SEC source: 0001840706-26-000222 · wk-form4_1782158492.xml · derivative · entry 2

Ossipow Vincent · CIK 0001773679 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 138,569

Underlying: Ordinary Shares · 28,818 shares

Expires 2036-06-18

F2 · derivative.exercise_date: The share options were granted on June 18, 2026 and vest 100% as of the date of the Issuer's next scheduled annual meeting of shareholders, subject to the Reporting Person's continued service to the Issuer through the relevant vesting date.

SEC source: 0001840706-26-000222 · wk-form4_1782158492.xml · nonDerivative · entry 1

Ossipow Vincent · CIK 0001773679 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 522,860

F1 · shares: Represents a restricted stock unit ("RSU") grant. Each RSU represents a contingent right to receive one ordinary share of the Issuer, subject to Reporting Person's continued service with the Issuer. The RSUs were granted on June 18, 2026 and vest 100% as of the date of the Issuer's next scheduled annual meeting of shareholders.

SEC source: 0001840706-26-000221 · wk-form4_1782158486.xml · derivative · entry 2

Cossery Jean-Michel · CIK 0002006455 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 138,449

Underlying: Ordinary Shares · 28,818 shares

Expires 2036-06-18

F2 · derivative.exercise_date: The share options were granted on June 18, 2026 and vest 100% as of the date of the Issuer's next scheduled annual meeting of shareholders, subject to the Reporting Person's continued service to the Issuer through the relevant vesting date.

SEC source: 0001840706-26-000221 · wk-form4_1782158486.xml · nonDerivative · entry 1

Cossery Jean-Michel · CIK 0002006455 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 206,212

F1 · shares: Represents a restricted stock unit ("RSU") grant. Each RSU represents a contingent right to receive one ordinary share of the Issuer, subject to Reporting Person's continued service with the Issuer. The RSUs were granted on June 18, 2026 and vest 100% as of the date of the Issuer's next scheduled annual meeting of shareholders.

SEC source: 0001840706-26-000211 · wk-form4_1781726561.xml · nonDerivative · entry 1

Xu Zhenyu · CIK 0002006362 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 622,280

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $4.90 to $5.13, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000209 · wk-form4_1781554395.xml · nonDerivative · entry 1

Menu Philippe · CIK 0002014308 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 245,780

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $4.81 to $5.15, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000207 · wk-form4_1781208356.xml · nonDerivative · entry 1

Camblong Jurgi · CIK 0002007050 · Director · Chief Executive Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,620,995

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $5.13 to $5.42, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000205 · wk-form4_1780689734.xml · nonDerivative · entry 1

CARDOZA GEORGE · CIK 0001518734 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 311,458

F1 · shares: This purchase was made during an open trading window in accordance with the company's insider trading policy.

SEC source: 0001840706-26-000203 · wk-form4_1780313930.xml · nonDerivative · entry 1

Menu Philippe · CIK 0002014308 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 250,780

F1 · shares: Transaction made pursuant to duly adopted trading plan under Rule 10b5-1(c).

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $4.78 to $5.01, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001840706-26-000198 · wk-form4_1779307360.xml · nonDerivative · entry 1

Menu Philippe · CIK 0002014308 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 255,780

F1 · shares: Represents shares sold by the Reporting Person in the open market to satisfy tax withholding obligations arising in connection with the vesting of restricted stock units on May 18, 2026. These sales were effected pursuant to a pre-established Rule 10b5-1(c) trading plan adopted by the Reporting Person and do not represent discretionary trades.

F2 · price: The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $4.54 to $4.66, inclusive. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.