SERA

SEC source: 0000950170-25-083332 · ownership.xml · derivative · entry 2

Barlow Jane F · CIK 0001736026 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Class A Common Stock · 25,000 shares

Expires 2035-06-05

F2 · derivative.exercise_date: Consists of stock options granted pursuant to Sera Prognostics, Inc.'s Non-Employee Director Compensation Policy and its 2021 Equity Incentive Plan. These stock options vest over one year as follows: 1/12 of the original grant amount vests in monthly installments for one year following the vesting commencement date, which is June 5, 2025.

SEC source: 0000950170-25-083332 · ownership.xml · nonDerivative · entry 1

Barlow Jane F · CIK 0001736026 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,713

F1 · shares: Each share is represented by a restricted stock unit ("RSU"). These RSUs vest over one year as follows: 1/12 of the original grant amount vests in monthly installments for one year following the vesting commencement date, which is June 5, 2025, subject to the Reporting Person continuing to provide services to the issuer.

SEC source: 0000950170-25-085688 · ownership.xml · nonDerivative · entry 1

Jackson Benjamin · CIK 0001779964 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 135,163

F1 · kind: These shares were purchased pursuant to the Sera Prognostics, Inc. 2021 Employee Stock Purchase Plan ("ESPP"), for the purchase period of December 2, 2024 to May 30, 2025, in a transaction that was exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0000950170-25-085687 · ownership.xml · nonDerivative · entry 1

Boniface John J. · CIK 0001870674 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 169,421

F1 · kind: These shares were purchased pursuant to the Sera Prognostics, Inc. 2021 Employee Stock Purchase Plan ("ESPP"), for the purchase period of December 2, 2024 to May 30, 2025, in a transaction that was exempt under both Rule 16b-3(d) and Rule 16b-3(c).

SEC source: 0000950170-25-068388 · ownership.xml · nonDerivative · entry 1

Harrison Robert Gardner · CIK 0001421563 · Chief Information Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 115,206

F1 · shares: Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by "sell to cover" transactions and does not represent a discretionary transaction by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $2.10 to $2.78, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

SEC source: 0000950170-25-068393 · ownership.xml · nonDerivative · entry 1

Lindgardt Zhenya · CIK 0001891299 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 867,251

F1 · shares: Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by "sell to cover" transactions and does not represent a discretionary transaction by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $2.10 to $2.78, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

SEC source: 0000950170-25-068394 · ownership.xml · nonDerivative · entry 1

Mirza Mansoor Raza · CIK 0001588389 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,672

F1 · shares: Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by "sell to cover" transactions and does not represent a discretionary transaction by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $2.10 to $2.78, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

SEC source: 0000950170-25-068390 · ownership.xml · nonDerivative · entry 1

Kearney Paul · CIK 0001888075 · Chief Data Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 196,711

F1 · shares: Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by "sell to cover" transactions and does not represent a discretionary transaction by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $2.10 to $2.78, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

SEC source: 0000950170-25-068389 · ownership.xml · nonDerivative · entry 1

Jackson Benjamin · CIK 0001779964 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 131,460

F1 · shares: Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by "sell to cover" transactions and does not represent a discretionary transaction by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $2.10 to $2.78, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

SEC source: 0000950170-25-068387 · ownership.xml · nonDerivative · entry 1

Boniface John J. · CIK 0001870674 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 165,718

F1 · shares: Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by "sell to cover" transactions and does not represent a discretionary transaction by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $2.10 to $2.78, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

SEC source: 0000950170-25-068386 · ownership.xml · nonDerivative · entry 1

Aerts Austin · CIK 0001979974 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 303,328

F1 · shares: Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by "sell to cover" transactions and does not represent a discretionary transaction by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $2.10 to $2.78, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

SEC source: 0000950170-25-052193 · ownership.xml · nonDerivative · entry 1

Mirza Mansoor Raza · CIK 0001588389 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,778

F1 · shares: Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by "sell to cover" transactions and does not represent a discretionary transaction by the Reporting Person.

SEC source: 0000950170-25-043347 · ownership.xml · derivative · entry 2

Elliott Jeffrey Thomas · CIK 0001689757 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,363

Underlying: Class A Common Stock · 47,363 shares

Expires 2035-03-20

F2 · derivative.exercise_date: These stock options vest over three years as follows: 1/36 of the original grant amount vests in monthly installments for three years following the vesting commencement date, which is March 20, 2025, subject to the Reporting Person continuing to provide services to the issuer.

SEC source: 0000950170-25-043347 · ownership.xml · nonDerivative · entry 1

Elliott Jeffrey Thomas · CIK 0001689757 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,534

F1 · shares: Each share is represented by a restricted stock unit ("RSU"). These RSUs vest over three years as follows: 1/36 of the original grant amount vests in monthly installments for three years following the vesting commencement date, which is March 20, 2025, subject to the Reporting Person continuing to provide services to the issuer.

SEC source: 0000950170-25-036529 · ownership.xml · nonDerivative · entry 1

Harrison Robert Gardner · CIK 0001421563 · Chief Information Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 121,757

F1 · kind: The transaction(s) reported on this Form 4 was/were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 14, 2024.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $4.02 to $4.33, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price.

SEC source: 0000950170-25-036528 · ownership.xml · nonDerivative · entry 2

Lindgardt Zhenya · CIK 0001891299 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 876,657

F2 · shares: Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by "sell to cover" transactions and does not represent a discretionary transaction by the Reporting Person.

F3 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $4.02 to $4.33, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

SEC source: 0000950170-25-036526 · ownership.xml · nonDerivative · entry 1

Aerts Austin · CIK 0001979974 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 309,702

F1 · shares: Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by "sell to cover" transactions and does not represent a discretionary transaction by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $4.02 to $4.33, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

SEC source: 0000950170-25-035801 · ownership.xml · nonDerivative · entry 2

Harrison Robert Gardner · CIK 0001421563 · Chief Information Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 125,631

F2 · shares: Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by "sell to cover" transactions and does not represent a discretionary transaction by the Reporting Person.

F3 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $4.07 to $4.24, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

SEC source: 0000950170-25-035804 · ownership.xml · nonDerivative · entry 1

Mirza Mansoor Raza · CIK 0001588389 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,885

F1 · shares: Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by "sell to cover" transactions and does not represent a discretionary transaction by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $4.07 to $4.24, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

SEC source: 0000950170-25-035803 · ownership.xml · nonDerivative · entry 2

Kearney Paul · CIK 0001888075 · Chief Data Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 203,800

F2 · shares: Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by "sell to cover" transactions and does not represent a discretionary transaction by the Reporting Person.

F3 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $4.07 to $4.24, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

SEC source: 0000950170-25-035802 · ownership.xml · nonDerivative · entry 2

Jackson Benjamin · CIK 0001779964 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 138,544

F2 · shares: Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by "sell to cover" transactions and does not represent a discretionary transaction by the Reporting Person.

F3 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $4.07 to $4.24, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

SEC source: 0000950170-25-035800 · ownership.xml · nonDerivative · entry 2

Boniface John J. · CIK 0001870674 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 170,850

F2 · shares: Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by "sell to cover" transactions and does not represent a discretionary transaction by the Reporting Person.

F3 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $4.07 to $4.24, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

SEC source: 0000950170-25-035799 · ownership.xml · nonDerivative · entry 2

Aerts Austin · CIK 0001979974 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 314,520

F2 · shares: Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by "sell to cover" transactions and does not represent a discretionary transaction by the Reporting Person.

F3 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $4.07 to $4.24, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

SEC source: 0000950170-25-036528 · ownership.xml · derivative · entry 3

Lindgardt Zhenya · CIK 0001891299 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 181,380

Underlying: Class A Common Stock · 181,380 shares

Expires 2035-03-06

F4 · derivative.exercise_date: These stock options vest over four years as follows: 1/48 of the original grant amount vests in monthly installments for four years following the vesting commencement date, which is March 10, 2025, subject to the Reporting Person continuing to provide services to the issuer.

SEC source: 0000950170-25-036528 · ownership.xml · nonDerivative · entry 1

Lindgardt Zhenya · CIK 0001891299 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 906,379

F1 · shares: Each share is represented by a restricted stock unit ("RSU"). These RSUs vest over four years as follows: 1/16 of the original grant amount vests in quarterly installments for four years following the vesting commencement date, which is March 10, 2025, subject to the Reporting Person continuing to provide services to the issuer.

SEC source: 0000950170-25-035801 · ownership.xml · derivative · entry 3

Harrison Robert Gardner · CIK 0001421563 · Chief Information Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,830

Underlying: Class A Common Stock · 36,830 shares

Expires 2035-03-05

F4 · derivative.exercise_date: These stock options vest over four years as follows: 1/48 of the original grant amount vests in monthly installments for four years following the vesting commencement date, which is March 10, 2025, subject to the Reporting Person continuing to provide services to the issuer.

SEC source: 0000950170-25-035801 · ownership.xml · nonDerivative · entry 1

Harrison Robert Gardner · CIK 0001421563 · Chief Information Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 128,882

F1 · shares: Each share is represented by a restricted stock unit ("RSU"). These RSUs vest over four years as follows: 1/16 of the original grant amount vests in quarterly installments for four years following the vesting commencement date, which is March 10, 2025, subject to the Reporting Person continuing to provide services to the issuer.

SEC source: 0000950170-25-035803 · ownership.xml · derivative · entry 3

Kearney Paul · CIK 0001888075 · Chief Data Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,810

Underlying: Class A Common Stock · 67,810 shares

Expires 2035-03-05

F4 · derivative.exercise_date: These stock options vest over four years as follows: 1/48 of the original grant amount vests in monthly installments for four years following the vesting commencement date, which is March 10, 2025, subject to the Reporting Person continuing to provide services to the issuer.

SEC source: 0000950170-25-035803 · ownership.xml · nonDerivative · entry 1

Kearney Paul · CIK 0001888075 · Chief Data Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 205,138

F1 · shares: Each share is represented by a restricted stock unit ("RSU"). These RSUs vest over four years as follows: 1/16 of the original grant amount vests in quarterly installments for four years following the vesting commencement date, which is March 10, 2025, subject to the Reporting Person continuing to provide services to the issuer.

SEC source: 0000950170-25-035802 · ownership.xml · derivative · entry 3

Jackson Benjamin · CIK 0001779964 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,420

Underlying: Class A Common Stock · 49,420 shares

Expires 2035-03-05

F4 · derivative.exercise_date: These stock options vest over four years as follows: 1/48 of the original grant amount vests in monthly installments for four years following the vesting commencement date, which is March 10, 2025, subject to the Reporting Person continuing to provide services to the issuer.

SEC source: 0000950170-25-035802 · ownership.xml · nonDerivative · entry 1

Jackson Benjamin · CIK 0001779964 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 140,829

F1 · shares: Each share is represented by a restricted stock unit ("RSU"). These RSUs vest over four years as follows: 1/16 of the original grant amount vests in quarterly installments for four years following the vesting commencement date, which is March 10, 2025, subject to the Reporting Person continuing to provide services to the issuer.

SEC source: 0000950170-25-035800 · ownership.xml · derivative · entry 3

Boniface John J. · CIK 0001870674 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 67,810

Underlying: Class A Common Stock · 67,810 shares

Expires 2035-03-05

F4 · derivative.exercise_date: These stock options vest over four years as follows: 1/48 of the original grant amount vests in monthly installments for four years following the vesting commencement date, which is March 10, 2025, subject to the Reporting Person continuing to provide services to the issuer.

SEC source: 0000950170-25-035800 · ownership.xml · nonDerivative · entry 1

Boniface John J. · CIK 0001870674 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 172,894

F1 · shares: Each share is represented by a restricted stock unit ("RSU"). These RSUs vest over four years as follows: 1/16 of the original grant amount vests in quarterly installments for four years following the vesting commencement date, which is March 10, 2025, subject to the Reporting Person continuing to provide services to the issuer.

SEC source: 0000950170-25-035799 · ownership.xml · derivative · entry 3

Aerts Austin · CIK 0001979974 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,810

Underlying: Class A Common Stock · 53,810 shares

Expires 2035-03-05

F4 · derivative.exercise_date: These stock options vest over four years as follows: 1/48 of the original grant amount vests in monthly installments for four years following the vesting commencement date, which is March 10, 2025, subject to the Reporting Person continuing to provide services to the issuer.

SEC source: 0000950170-25-035799 · ownership.xml · nonDerivative · entry 1

Aerts Austin · CIK 0001979974 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 315,060

F1 · shares: Each share is represented by a restricted stock unit ("RSU"). These RSUs vest over four years as follows: 1/16 of the original grant amount vests in quarterly installments for four years following the vesting commencement date, which is March 10, 2025, subject to the Reporting Person continuing to provide services to the issuer.

SEC source: 0000950170-25-021248 · ownership.xml · nonDerivative · entry 1

Harrison Robert Gardner · CIK 0001421563 · Chief Information Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 103,112

F1 · kind: The transaction(s) reported on this Form 4 was/were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 14, 2024.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $4.20 to $4.36, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price.

SEC source: 0000950170-25-021194 · ownership.xml · nonDerivative · entry 1

Jackson Benjamin · CIK 0001779964 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 106,239

F1 · shares: Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by "sell to cover" transactions and does not represent a discretionary transaction by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $4.14 to $5.09, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

SEC source: 0000950170-25-021187 · ownership.xml · nonDerivative · entry 1

Harrison Robert Gardner · CIK 0001421563 · Chief Information Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 106,722

F1 · shares: Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by "sell to cover" transactions and does not represent a discretionary transaction by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $4.14 to $5.09, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

SEC source: 0000950170-25-021199 · ownership.xml · nonDerivative · entry 1

Mirza Mansoor Raza · CIK 0001588389 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 43,984

F1 · shares: Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by "sell to cover" transactions and does not represent a discretionary transaction by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $4.14 to $5.09, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

SEC source: 0000950170-25-021198 · ownership.xml · nonDerivative · entry 1

Lindgardt Zhenya · CIK 0001891299 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 779,459

F1 · shares: Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by "sell to cover" transactions and does not represent a discretionary transaction by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $4.14 to $5.09, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

SEC source: 0000950170-25-021196 · ownership.xml · nonDerivative · entry 1

Kearney Paul · CIK 0001888075 · Chief Data Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 158,128

F1 · shares: Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by "sell to cover" transactions and does not represent a discretionary transaction by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $4.14 to $5.09, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

SEC source: 0000950170-25-021185 · ownership.xml · nonDerivative · entry 1

Boniface John J. · CIK 0001870674 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 125,884

F1 · shares: Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by "sell to cover" transactions and does not represent a discretionary transaction by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $4.14 to $5.09, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

F3 · balance_after: Includes 5,000 and 1,679 shares of Class A Common Stock purchased pursuant to the Sera Prognostics, Inc. 2021 Employee Stock Purchase Plan ("ESPP"), for the purchase periods of December 1, 2023 to May 31, 2024 and June 3, 2024 to November 30, 2024, respectively.

SEC source: 0000950170-25-021183 · ownership.xml · nonDerivative · entry 1

Aerts Austin · CIK 0001979974 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 277,410

F1 · shares: Represents the number of shares sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs"). The sale is mandated by the Issuer's election to require the satisfaction of tax withholding obligations to be funded by "sell to cover" transactions and does not represent a discretionary transaction by the Reporting Person.

F2 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $4.14 to $5.09, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

SEC source: 0000950170-25-020182 · ownership.xml · nonDerivative · entry 1

Harrison Robert Gardner · CIK 0001421563 · Chief Information Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 114,019

F1 · kind: The transaction(s) reported on this Form 4 was/were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 14, 2024.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.92 to $3.99, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price.

SEC source: 0000950170-25-009338 · ownership.xml · derivative · entry 2

Mirza Mansoor Raza · CIK 0001588389 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Class A Common Stock · 37,549 shares

Expires 2025-02-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The shares subject to this option are fully vested and exercisable.

SEC source: 0000950170-25-009338 · ownership.xml · nonDerivative · entry 1

Mirza Mansoor Raza · CIK 0001588389 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 44,085

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000950170-25-005590 · ownership.xml · nonDerivative · entry 16

Phillips Joshua · CIK 0001871555 · Director

10b5-1 filing: Plan reported

Ownership: Indirect · Held by Catalyst Health Ventures (PF), L.P.

Disclosed balance after: 0

F1 · kind: The transaction(s) reported on this Form 4 was/were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 10, 2024.

F5 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $6.03 to $6.57, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

F6 · ownership.nature: CHV GP LLC is the general partner of CHV LP and Catalyst Health Ventures (PF), L.P. ("CHV PF"). CHV I GP LLC (formerly known as "CHV III GP LLC") is the general partner of CHV Investments LLC ("CHV Investments") and Catalyst Health Ventures Follow-on Fund, L.P. ("CHV FO", together with CHV LP, CHV PF and CHV Investments, the "CHV Funds"). Joshua Phillips, a member of the Issuer's board of directors, is a managing member of CHV GP LLC and CHV I GP LLC, and a limited partner of CHV PF, CHV Investments, CHV GP LLC, and CHV I GP LLC. The securities held by the CHV Funds may be deemed to be beneficially owned by Joshua Phillips. Joshua Phillips disclaims beneficial ownership of these securities except to the extent of his pecuniary benefit therein.

SEC source: 0000950170-25-005590 · ownership.xml · nonDerivative · entry 12

Phillips Joshua · CIK 0001871555 · Director

10b5-1 filing: Plan reported

Ownership: Indirect · Held by Catalyst Health Ventures, L.P.

Disclosed balance after: 0

F1 · kind: The transaction(s) reported on this Form 4 was/were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 10, 2024.

F5 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $6.03 to $6.57, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

F6 · ownership.nature: CHV GP LLC is the general partner of CHV LP and Catalyst Health Ventures (PF), L.P. ("CHV PF"). CHV I GP LLC (formerly known as "CHV III GP LLC") is the general partner of CHV Investments LLC ("CHV Investments") and Catalyst Health Ventures Follow-on Fund, L.P. ("CHV FO", together with CHV LP, CHV PF and CHV Investments, the "CHV Funds"). Joshua Phillips, a member of the Issuer's board of directors, is a managing member of CHV GP LLC and CHV I GP LLC, and a limited partner of CHV PF, CHV Investments, CHV GP LLC, and CHV I GP LLC. The securities held by the CHV Funds may be deemed to be beneficially owned by Joshua Phillips. Joshua Phillips disclaims beneficial ownership of these securities except to the extent of his pecuniary benefit therein.

SEC source: 0000950170-25-005590 · ownership.xml · nonDerivative · entry 8

Phillips Joshua · CIK 0001871555 · Director

10b5-1 filing: Plan reported

Ownership: Indirect · Held by CHV Investments, LLC

Disclosed balance after: 0

F1 · kind: The transaction(s) reported on this Form 4 was/were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 10, 2024.

F5 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $6.03 to $6.57, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

F6 · ownership.nature: CHV GP LLC is the general partner of CHV LP and Catalyst Health Ventures (PF), L.P. ("CHV PF"). CHV I GP LLC (formerly known as "CHV III GP LLC") is the general partner of CHV Investments LLC ("CHV Investments") and Catalyst Health Ventures Follow-on Fund, L.P. ("CHV FO", together with CHV LP, CHV PF and CHV Investments, the "CHV Funds"). Joshua Phillips, a member of the Issuer's board of directors, is a managing member of CHV GP LLC and CHV I GP LLC, and a limited partner of CHV PF, CHV Investments, CHV GP LLC, and CHV I GP LLC. The securities held by the CHV Funds may be deemed to be beneficially owned by Joshua Phillips. Joshua Phillips disclaims beneficial ownership of these securities except to the extent of his pecuniary benefit therein.

SEC source: 0000950170-25-005590 · ownership.xml · nonDerivative · entry 4

Phillips Joshua · CIK 0001871555 · Director

10b5-1 filing: Plan reported

Ownership: Indirect · Held by Catalyst Health Ventures Follow-on Fund, L.P.

Disclosed balance after: 0

F1 · kind: The transaction(s) reported on this Form 4 was/were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 10, 2024.

F5 · price: The price reported is a weighted average price. These shares were sold as part of a block trade in multiple transactions at prices ranging from $6.03 to $6.57, inclusive. The Reporting Person will provide to the staff of the Securities and Exchange Commission, the issuer, or any security holder of the issuer, upon request, full information regarding the number of shares sold at each separate price with regard to the block trade.

F6 · ownership.nature: CHV GP LLC is the general partner of CHV LP and Catalyst Health Ventures (PF), L.P. ("CHV PF"). CHV I GP LLC (formerly known as "CHV III GP LLC") is the general partner of CHV Investments LLC ("CHV Investments") and Catalyst Health Ventures Follow-on Fund, L.P. ("CHV FO", together with CHV LP, CHV PF and CHV Investments, the "CHV Funds"). Joshua Phillips, a member of the Issuer's board of directors, is a managing member of CHV GP LLC and CHV I GP LLC, and a limited partner of CHV PF, CHV Investments, CHV GP LLC, and CHV I GP LLC. The securities held by the CHV Funds may be deemed to be beneficially owned by Joshua Phillips. Joshua Phillips disclaims beneficial ownership of these securities except to the extent of his pecuniary benefit therein.