SDGR

SEC source: 0001797707-26-000001 · wk-form4_1772573657.xml · nonDerivative · entry 4

Farid Ramy · CIK 0001797707 · Director · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 334,485

F4 · kind: This sale was effected pursuant to a durable automatic sale instruction under Rule 10b5-1 adopted by the reporting person on March 8, 2023, and represents a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of PRSUs. The sale does not represent a discretionary trade by the reporting person.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $11.69 to $12.14, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote (5) of this Form 4.

F6 · balance_after: Includes an aggregate of 142,009 unvested RSUs.

SEC source: 0001797707-26-000001 · wk-form4_1772573657.xml · nonDerivative · entry 3

Farid Ramy · CIK 0001797707 · Director · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 340,045

F3 · kind: Represents PRSUs previously granted to the reporting person on March 4, 2024, for which the compensation committee of the Issuer's board of directors certified on March 2, 2026 the level of achievement of the performance metrics for the PRSUs. The PRSUs will vest upon the filing of the Issuer's Annual Report on Form 10-K for the year ended December 31, 2026, subject to the reporting person's continued service with the company.

SEC source: 0001797707-26-000001 · wk-form4_1772573657.xml · nonDerivative · entry 2

Farid Ramy · CIK 0001797707 · Director · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 291,786

F2 · kind: Represents the portion of the performance-based restricted stock units ("PRSUs") that were previously granted to the reporting person on February 9, 2023 in connection with the Issuer's annual grant of equity in 2023, that vested on March 2, 2026 following certification by the compensation committee of the Issuer's board of directors of the level of achievement of certain performance metrics for the PRSUs.

SEC source: 0001797707-26-000001 · wk-form4_1772573657.xml · nonDerivative · entry 1

Farid Ramy · CIK 0001797707 · Director · President & CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 278,182

F1 · security: Grant of restricted stock units ("RSUs") under the Issuer's 2022 Equity Incentive Plan, as amended. Each RSU represents a contingent right to receive one share of common stock of the Issuer. The RSUs were granted on March 2, 2026 and will vest in equal installments on each of March 9, 2027, 2028, 2029 and 2030, subject to the reporting person's continued service with the company.

SEC source: 0001797777-26-000003 · wk-form4_1772573594.xml · derivative · entry 3

Tran Yvonne · CIK 0001797777 · EVP, CLO & CPO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,250

Underlying: Common Stock · 34,250 shares

Expires 2036-03-02

F4 · derivative.exercise_date: The option was granted on March 2, 2026. The shares underlying the option are scheduled to vest with respect to 25% of the shares on March 2, 2027 and the remainder are scheduled to vest in equal monthly installments through March 2, 2030, subject to the reporting person's continued service with the company.

SEC source: 0001797777-26-000003 · wk-form4_1772573594.xml · nonDerivative · entry 2

Tran Yvonne · CIK 0001797777 · EVP, CLO & CPO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,777

F2 · kind: Represents portion of the performance-based restricted stock units ("PRSUs") previously granted to the reporting person on March 4, 2024, for which the compensation committee of the Issuer's board of directors certified on March 2, 2026 the level of achievement of the performance metrics for the PRSUs. The PRSUs will vest upon the filing of the Issuer's Annual Report on Form 10-K for the year ended December 31, 2026, subject to the reporting person's continued service with the company.

F3 · balance_after: Includes an aggregate of 45,316 unvested RSUs.

SEC source: 0001797777-26-000003 · wk-form4_1772573594.xml · nonDerivative · entry 1

Tran Yvonne · CIK 0001797777 · EVP, CLO & CPO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,989

F1 · security: Grant of restricted stock units ("RSUs") under the Issuer's 2022 Equity Incentive Plan, as amended. Each RSU represents a contingent right to receive one share of common stock of the Issuer. The RSUs were granted on March 2, 2026 and will vest in equal installments on each of March 9, 2027, 2028, 2029 and 2030, subject to the reporting person's continued service with the company.

SEC source: 0001797785-26-000003 · wk-form4_1772573545.xml · derivative · entry 2

Herman Jenny · CIK 0001797785 · CAO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,220

Underlying: Common Stock · 8,220 shares

Expires 2036-03-02

F3 · derivative.exercise_date: The option was granted on March 2, 2026. The shares underlying the option are scheduled to vest with respect to 25% of the shares on March 2, 2027 and the remainder are scheduled to vest in equal monthly installments through March 2, 2030, subject to the reporting person's continued service with the company.

SEC source: 0001797785-26-000003 · wk-form4_1772573545.xml · nonDerivative · entry 1

Herman Jenny · CIK 0001797785 · CAO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,187

F1 · security: Grant of restricted stock units ("RSUs") under the Issuer's 2022 Equity Incentive Plan, as amended. Each RSU represents a contingent right to receive one share of common stock of the Issuer. The RSUs were granted on March 2, 2026 and will vest in equal installments on each of March 9, 2027, 2028, 2029 and 2030, subject to the reporting person's continued service with the company.

F2 · balance_after: Includes an aggregate of 26,875 unvested RSUs.

SEC source: 0001797672-26-000001 · wk-form4_1772573497.xml · derivative · entry 5

Akinsanya Karen · CIK 0001797672 · See Remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 48,500

Underlying: Common Stock · 48,500 shares

Expires 2036-03-02

F7 · derivative.exercise_date: The option was granted on March 2, 2026. The shares underlying the option are scheduled to vest with respect to 25% of the shares on March 2, 2027 and the remainder are scheduled to vest in equal monthly installments through March 2, 2030, subject to the reporting person's continued service with the company.

SEC source: 0001797672-26-000001 · wk-form4_1772573497.xml · nonDerivative · entry 4

Akinsanya Karen · CIK 0001797672 · See Remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 71,322

F4 · kind: This sale was effected pursuant to a durable automatic sale instruction under Rule 10b5-1 adopted by the reporting person on March 8, 2023, and represents a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of PRSUs. The sale does not represent a discretionary trade by the reporting person.

F5 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $11.70 to $12.28, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote (5) of this Form 4.

F6 · balance_after: Includes an aggregate of 67,451 unvested RSUs.

SEC source: 0001797672-26-000001 · wk-form4_1772573497.xml · nonDerivative · entry 3

Akinsanya Karen · CIK 0001797672 · See Remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 73,528

F3 · kind: Represents PRSUs previously granted to the reporting person on March 4, 2024, for which the compensation committee of the Issuer's board of directors certified on March 2, 2026 the level of achievement of the performance metrics for the PRSUs. The PRSUs will vest upon the filing of the Issuer's Annual Report on Form 10-K for the year ended December 31, 2026, subject to the reporting person's continued service with the company.

SEC source: 0001797672-26-000001 · wk-form4_1772573497.xml · nonDerivative · entry 2

Akinsanya Karen · CIK 0001797672 · See Remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 45,952

F2 · kind: Represents the portion of the performance-based restricted stock units ("PRSUs") that were previously granted to the reporting person on February 9, 2023 in connection with the Issuer's annual grant of equity in 2023, that vested on March 2, 2026 following certification by the compensation committee of the Issuer's board of directors of the level of achievement of certain performance metrics for the PRSUs.

SEC source: 0001797672-26-000001 · wk-form4_1772573497.xml · nonDerivative · entry 1

Akinsanya Karen · CIK 0001797672 · See Remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 39,875

F1 · security: Grant of restricted stock units ("RSUs") under the Issuer's 2022 Equity Incentive Plan, as amended. Each RSU represents a contingent right to receive one share of common stock of the Issuer. The RSUs were granted on March 2, 2026 and will vest in equal installments on each of March 9, 2027, 2028, 2029 and 2030, subject to the reporting person's continued service with the company.

SEC source: 0002066297-26-000001 · wk-form4_1772573468.xml · derivative · entry 2

Aklian Mannix Vartan · CIK 0002066297 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,250

Underlying: Common Stock · 34,250 shares

Expires 2036-03-02

F3 · derivative.exercise_date: The option was granted on March 2, 2026. The shares underlying the option are scheduled to vest with respect to 25% of the shares on March 2, 2027 and the remainder are scheduled to vest in equal monthly installments through March 2, 2030, subject to the reporting person's continued service with the company.

SEC source: 0002066297-26-000001 · wk-form4_1772573468.xml · nonDerivative · entry 1

Aklian Mannix Vartan · CIK 0002066297 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,193

F1 · security: Grant of restricted stock units ("RSUs") under the Issuer's 2022 Equity Incentive Plan, as amended. Each RSU represents a contingent right to receive one share of common stock of the Issuer. The RSUs were granted on March 2, 2026 and will vest in equal installments on each of March 9, 2027, 2028, 2029 and 2030, subject to the reporting person's continued service with the company.

F2 · balance_after: Includes 31,193 unvested RSUs.

SEC source: 0001798179-26-000004 · wk-form4_1772573439.xml · derivative · entry 3

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 34,250

Underlying: Common Stock · 34,250 shares

Expires 2036-03-02

F4 · derivative.exercise_date: The option was granted on March 2, 2026. The shares underlying the option are scheduled to vest with respect to 25% of the shares on March 2, 2027 and the remainder are scheduled to vest in equal monthly installments through March 2, 2030, subject to the reporting person's continued service with the company.

SEC source: 0001798179-26-000004 · wk-form4_1772573439.xml · nonDerivative · entry 2

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 57,197

F2 · kind: Represents portion of the performance-based restricted stock units ("PRSUs") previously granted to the reporting person on March 4, 2024 and March 21, 2024, for which the compensation committee of the Issuer's board of directors certified on March 2, 2026 the level of achievement of the performance metrics for the PRSUs. The PRSUs will vest upon the filing of the Issuer's Annual Report on Form 10-K for the year ended December 31, 2026, subject to the reporting person's continued service with the company.

F3 · balance_after: Includes an aggregate of 52,949 unvested RSUs.

SEC source: 0001798179-26-000004 · wk-form4_1772573439.xml · nonDerivative · entry 1

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,515

F1 · security: Grant of restricted stock units ("RSUs") under the Issuer's 2022 Equity Incentive Plan, as amended. Each RSU represents a contingent right to receive one share of common stock of the Issuer. The RSUs were granted on March 2, 2026 and will vest in equal installments on each of March 9, 2027, 2028, 2029 and 2030, subject to the reporting person's continued service with the company.

SEC source: 0001797730-26-000002 · wk-form4_1770931354.xml · nonDerivative · entry 1

Lorton Kenneth Patrick · CIK 0001797730 · EVP, CTO & COO, Software

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 52,651

F1 · kind: This sale was effected pursuant to a durable automatic sale instruction under Rule 10b5-1 adopted by the reporting person on March 9, 2023, and represents a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of restricted stock units ("RSUs"). The sale does not represent a discretionary trade by the reporting person.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $13.625 to $13.8575, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote (2) of this Form 4.

F3 · balance_after: Includes 14,543 unvested RSUs.

SEC source: 0001797777-26-000002 · wk-form4_1770931395.xml · nonDerivative · entry 1

Tran Yvonne · CIK 0001797777 · EVP, CLO & CPO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 22,859

F1 · kind: This sale was effected pursuant to a durable automatic sale instruction under Rule 10b5-1 adopted by the reporting person on March 8, 2023, and represents a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of restricted stock units ("RSUs"). The sale does not represent a discretionary trade by the reporting person.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $13.555 to $13.90, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote (2) of this Form 4.

F3 · balance_after: Includes 14,398 unvested RSUs.

SEC source: 0001797785-26-000002 · wk-form4_1770931311.xml · nonDerivative · entry 1

Herman Jenny · CIK 0001797785 · CAO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 26,597

F1 · kind: This sale was effected pursuant to a durable automatic sale instruction under Rule 10b5-1 adopted by the reporting person on March 11, 2023, and represents a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of restricted stock units ("RSUs"). The sale does not represent a discretionary trade by the reporting person.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $13.71 to $13.85, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote (2) of this Form 4.

F3 · balance_after: Includes 17,285 unvested RSUs.

SEC source: 0001798179-26-000002 · wk-form4_1770850833.xml · nonDerivative · entry 1

Abel Robert Lorne · CIK 0001798179 · See Remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 19,385

F1 · kind: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 13, 2023, and represents a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of restricted stock units ("RSUs"). The sale does not represent a discretionary trade by the reporting person.

F2 · balance_after: Includes 15,137 unvested RSUs.

SEC source: 0001628280-25-045361 · wk-form4_1760732891.xml · nonDerivative · entry 1

Dugan Margaret · CIK 0001909734 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 24,574

F1 · kind: This sale was effected pursuant to a durable automatic sale instruction under Rule 10b5-1 adopted by the reporting person on November 13, 2023, and represents a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of restricted stock units ("RSUs"). The sale does not represent a discretionary trade by the reporting person.

F2 · balance_after: Includes 20,000 unvested RSUs.

SEC source: 0001490978-25-000092 · wk-form4_1750451851.xml · derivative · entry 2

Chodakewitz Jeffrey · CIK 0001610876 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,341

Underlying: Common Stock · 9,341 shares

Expires 2035-06-18

F3 · derivative.exercise_date: The option was granted on June 18, 2025 under the Issuer's 2022 Equity Incentive Plan, as amended. The award shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service.

SEC source: 0001490978-25-000092 · wk-form4_1750451851.xml · nonDerivative · entry 1

Chodakewitz Jeffrey · CIK 0001610876 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,247

F1 · security: Grant of restricted stock units ("RSUs") under the Issuer's 2022 Equity Incentive Plan, as amended. Each RSU represents a contingent right to receive one share of common stock of the Issuer. The RSUs were granted on June 18, 2025 and shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service. The settlement of such RSUs will be deferred until the earlier of (i) the 30th day following the reporting person's separation from service from the Issuer or (ii) certain change in control events.

F2 · balance_after: Includes 5,997 unvested RSUs.

SEC source: 0001490978-25-000091 · wk-form4_1750451757.xml · derivative · entry 2

Sender Gary · CIK 0001659085 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,341

Underlying: Common Stock · 9,341 shares

Expires 2035-06-18

F3 · derivative.exercise_date: The option was granted on June 18, 2025 under the Issuer's 2022 Equity Incentive Plan, as amended. The award shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service.

SEC source: 0001490978-25-000091 · wk-form4_1750451757.xml · nonDerivative · entry 1

Sender Gary · CIK 0001659085 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,247

F1 · security: Grant of restricted stock units ("RSUs") under the Issuer's 2022 Equity Incentive Plan, as amended. Each RSU represents a contingent right to receive one share of common stock of the Issuer. The RSUs were granted on June 18, 2025 and shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service.

F2 · balance_after: Includes 5,997 unvested RSUs.

SEC source: 0001490978-25-000090 · wk-form4_1750451697.xml · derivative · entry 2

Lynton Michael · CIK 0001606115 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,341

Underlying: Common Stock · 9,341 shares

Expires 2035-06-18

F3 · derivative.exercise_date: The option was granted on June 18, 2025 under the Issuer's 2022 Equity Incentive Plan, as amended. The award shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service.

SEC source: 0001490978-25-000090 · wk-form4_1750451697.xml · nonDerivative · entry 1

Lynton Michael · CIK 0001606115 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,247

F1 · security: Grant of restricted stock units ("RSUs") under the Issuer's 2022 Equity Incentive Plan, as amended. Each RSU represents a contingent right to receive one share of common stock of the Issuer. The RSUs were granted on June 18, 2025 and shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service. The settlement of such RSUs will be deferred until the earlier of (i) the 30th day following the reporting person's separation from service from the Issuer or (ii) certain change in control events.

F2 · balance_after: Includes 5,997 unvested RSUs.

SEC source: 0001490978-25-000089 · wk-form4_1750451637.xml · derivative · entry 2

van Kralingen Bridget A · CIK 0001538977 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,335

Underlying: Common Stock · 2,335 shares

Expires 2035-06-18

F3 · derivative.exercise_date: The option was granted on June 18, 2025 under the Issuer's 2022 Equity Incentive Plan, as amended. The award shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service.

SEC source: 0001490978-25-000089 · wk-form4_1750451637.xml · nonDerivative · entry 1

van Kralingen Bridget A · CIK 0001538977 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,499

F1 · security: Grant of restricted stock units ("RSUs") under the Issuer's 2022 Equity Incentive Plan, as amended. Each RSU represents a contingent right to receive one share of common stock of the Issuer. The RSUs were granted on June 18, 2025 and shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service. The settlement of such RSUs will be deferred until the earlier of (i) the 30th day following the reporting person's separation from service from the Issuer or (ii) certain change in control events.

F2 · balance_after: Includes 11,499 unvested RSUs.

SEC source: 0001490978-25-000088 · wk-form4_1750451543.xml · derivative · entry 2

Thornberry Nancy · CIK 0001797826 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,341

Underlying: Common Stock · 9,341 shares

Expires 2035-06-18

F3 · derivative.exercise_date: The option was granted on June 18, 2025 under the Issuer's 2022 Equity Incentive Plan, as amended. The award shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service.

SEC source: 0001490978-25-000088 · wk-form4_1750451543.xml · nonDerivative · entry 1

Thornberry Nancy · CIK 0001797826 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,247

F1 · security: Grant of restricted stock units ("RSUs") under the Issuer's 2022 Equity Incentive Plan, as amended. Each RSU represents a contingent right to receive one share of common stock of the Issuer. The RSUs were granted on June 18, 2025 and shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service. The settlement of such RSUs will be deferred until the earlier of (i) the 30th day following the reporting person's separation from service from the Issuer or (ii) certain change in control events.

F2 · balance_after: Includes 5,997 unvested RSUs.

SEC source: 0001490978-25-000086 · wk-form4_1750451370.xml · derivative · entry 2

GINSBERG GARY L · CIK 0001236136 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,341

Underlying: Common Stock · 9,341 shares

Expires 2035-06-18

F3 · derivative.exercise_date: The option was granted on June 18, 2025 under the Issuer's 2022 Equity Incentive Plan, as amended. The award shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service.

SEC source: 0001490978-25-000086 · wk-form4_1750451370.xml · nonDerivative · entry 1

GINSBERG GARY L · CIK 0001236136 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,247

F1 · security: Grant of restricted stock units ("RSUs") under the Issuer's 2022 Equity Incentive Plan, as amended. Each RSU represents a contingent right to receive one share of common stock of the Issuer. The RSUs were granted on June 18, 2025 and shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service. The settlement of such RSUs will be deferred until the earlier of (i) the 30th day following the reporting person's separation from service from the Issuer or (ii) certain change in control events.

F2 · balance_after: Includes 5,997 unvested RSUs.

SEC source: 0001490978-25-000087 · wk-form4_1750451447.xml · derivative · entry 2

Kapeller-Libermann Rosana · CIK 0001797835 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,341

Underlying: Common Stock · 9,341 shares

Expires 2035-06-18

F3 · derivative.exercise_date: The option was granted on June 18, 2025 under the Issuer's 2022 Equity Incentive Plan, as amended. The award shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service.

SEC source: 0001490978-25-000087 · wk-form4_1750451447.xml · nonDerivative · entry 1

Kapeller-Libermann Rosana · CIK 0001797835 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,247

F1 · security: Grant of restricted stock units ("RSUs") under the Issuer's 2022 Equity Incentive Plan, as amended. Each RSU represents a contingent right to receive one share of common stock of the Issuer. The RSUs were granted on June 18, 2025 and shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service. The settlement of such RSUs will be deferred until the earlier of (i) the 30th day following the reporting person's separation from service from the Issuer or (ii) certain change in control events.

F2 · balance_after: Includes 5,997 unvested RSUs.

SEC source: 0001490978-25-000085 · wk-form4_1750451301.xml · derivative · entry 2

OBEROI ARUN · CIK 0001275887 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,341

Underlying: Common Stock · 9,341 shares

Expires 2035-06-18

F3 · derivative.exercise_date: The option was granted on June 18, 2025 under the Issuer's 2022 Equity Incentive Plan, as amended. The award shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service.

SEC source: 0001490978-25-000085 · wk-form4_1750451301.xml · nonDerivative · entry 1

OBEROI ARUN · CIK 0001275887 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,247

F1 · security: Grant of restricted stock units ("RSUs") under the Issuer's 2022 Equity Incentive Plan, as amended. Each RSU represents a contingent right to receive one share of common stock of the Issuer. The RSUs were granted on June 18, 2025 and shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service.

F2 · balance_after: Includes 5,997 unvested RSUs.

SEC source: 0001490978-25-000084 · wk-form4_1750451124.xml · derivative · entry 4

Friesner Richard · CIK 0001798426 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,341

Underlying: Common Stock · 9,341 shares

Expires 2035-06-18

F4 · derivative.exercise_date: The option was granted on June 18, 2025 under the Issuer's 2022 Equity Incentive Plan, as amended. The award shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service.

SEC source: 0001490978-25-000084 · wk-form4_1750451124.xml · nonDerivative · entry 1

Friesner Richard · CIK 0001798426 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 521,697

F1 · security: Grant of restricted stock units ("RSUs") under the Issuer's 2022 Equity Incentive Plan, as amended. Each RSU represents a contingent right to receive one share of common stock of the Issuer. The RSUs were granted on June 18, 2025 and shall vest on the twelve-month anniversary of the date of grant of the award (or, if earlier, the date of the next annual meeting of stockholders following the date of grant of the award), subject to continued service. The settlement of such RSUs will be deferred until the earlier of (i) the 30th day following the reporting person's separation from service from the Issuer or (ii) certain change in control events.

F2 · balance_after: Includes 5,997 unvested RSUs.

SEC source: 0001490978-25-000070 · wk-form4_1748553909.xml · derivative · entry 2

Aklian Mannix Vartan · CIK 0002066297 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 84,375

Underlying: Common Stock · 84,375 shares

Expires 2035-05-29

F3 · derivative.exercise_date: The option was granted on May 29, 2025 under the Issuer's 2021 Inducement Equity Incentive Plan. The shares underlying the option are scheduled to vest with respect to 25% of the shares on May 28, 2026 and the remainder are scheduled to vest in equal monthly installments through May 28, 2029, subject to the Reporting Person's continued service with the company.

SEC source: 0001490978-25-000070 · wk-form4_1748553909.xml · nonDerivative · entry 1

Aklian Mannix Vartan · CIK 0002066297 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,063

F1 · security: Grant of restricted stock units ("RSUs") under the Issuer's 2021 Inducement Equity Incentive Plan. Each RSU represents a contingent right to receive one share of common stock of the Issuer. The RSUs were granted on May 29, 2025 and will vest in equal installments on each of July 15, 2026, 2027, 2028 and 2029, subject to the Reporting Person's continued service with the company.

F2 · balance_after: Includes 14,063 unvested RSUs

SEC source: 0001490978-25-000066 · wk-form4_1747945393.xml · derivative · entry 2

Jain Rachit · CIK 0002068195 · EVP & CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,750

Underlying: Common Stock · 18,750 shares

Expires 2035-05-21

F3 · derivative.exercise_date: The option was granted on May 21, 2025. The shares underlying the option are scheduled to vest with respect to 25% of the shares on May 16, 2025 and the remainder are scheduled to vest in equal monthly installments through May 16, 2029, subject to the Reporting Person's continued service with the company.

SEC source: 0001490978-25-000066 · wk-form4_1747945393.xml · nonDerivative · entry 1

Jain Rachit · CIK 0002068195 · EVP & CFO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 37,097

F1 · security: Grant of restricted stock units ("RSUs") under the Issuer's 2022 Equity Incentive Plan, as amended. Each RSU represents a contingent right to receive one share of common stock of the Issuer. The RSUs were granted on May 21, 2025 and will vest in equal installments on each of July 15, 2026, 2027, 2028 and 2029, subject to the Reporting Person's continued service with the company.

F2 · balance_after: Includes 35,530 unvested RSUs.

SEC source: 0001490978-25-000036 · wk-form4_1744749073.xml · derivative · entry 7

Akinsanya Karen · CIK 0001797672 · President of R&D, Therapeutics

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,345 shares

Expires 2027-10-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 17, 2024.

F6 · derivative.exercise_date: The option was granted on October 10, 2017 and is fully vested.

SEC source: 0001490978-25-000036 · wk-form4_1744749073.xml · derivative · entry 6

Akinsanya Karen · CIK 0001797672 · President of R&D, Therapeutics

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 13,378 shares

Expires 2028-08-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 17, 2024.

F5 · derivative.exercise_date: The option was granted on August 3, 2018 and is fully vested.

SEC source: 0001490978-25-000036 · wk-form4_1744749073.xml · nonDerivative · entry 5

Akinsanya Karen · CIK 0001797672 · President of R&D, Therapeutics

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,625

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 17, 2024.

F2 · balance_after: Includes 15,625 unvested RSUs.

SEC source: 0001490978-25-000036 · wk-form4_1744749073.xml · nonDerivative · entry 4

Akinsanya Karen · CIK 0001797672 · President of R&D, Therapeutics

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 18,970

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 17, 2024.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $25.00 to $25.24, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (3) through (4) of this form 4.

F2 · balance_after: Includes 15,625 unvested RSUs.