RYTM

SEC source: 0001104659-25-078815 · tm2523328-3_4seq1.xml · nonDerivative · entry 4

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 116,915

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

SEC source: 0001104659-25-078815 · tm2523328-3_4seq1.xml · nonDerivative · entry 3

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 120,392

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-25-078814 · tm2523328-2_4seq1.xml · derivative · entry 5

German Christopher Paul · CIK 0001260835 · Corporate Controller & CAO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,050

Underlying: Common Stock · 500 shares

Expires 2034-02-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The stock options were granted on February 16, 2024. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

SEC source: 0001104659-25-078814 · tm2523328-2_4seq1.xml · derivative · entry 4

German Christopher Paul · CIK 0001260835 · Corporate Controller & CAO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,231

Underlying: Common Stock · 1,000 shares

Expires 2033-04-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The stock options were granted on April 4, 2023. The options vest and become exercisable as to 25% of the total shares on March 20, 2024 and, thereafter, as to the remaining 75% of the total shares in twelve equal quarterly installments of 6.25% beginning June 20, 2024 and ending March 20, 2027, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001104659-25-078814 · tm2523328-2_4seq1.xml · nonDerivative · entry 3

German Christopher Paul · CIK 0001260835 · Corporate Controller & CAO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 922

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 11, 2025.

SEC source: 0001104659-25-078814 · tm2523328-2_4seq1.xml · nonDerivative · entry 2

German Christopher Paul · CIK 0001260835 · Corporate Controller & CAO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,422

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-25-078814 · tm2523328-2_4seq1.xml · nonDerivative · entry 1

German Christopher Paul · CIK 0001260835 · Corporate Controller & CAO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,922

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-25-078815 · tm2523328-3_4seq1.xml · derivative · entry 5

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,477

Underlying: Common Stock · 24,611 shares

Expires 2027-08-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The stock option is fully vested.

SEC source: 0001104659-25-078815 · tm2523328-3_4seq1.xml · nonDerivative · entry 2

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 116,915

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

F2 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $96.00 to $96.63 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001104659-25-078815 · tm2523328-3_4seq1.xml · nonDerivative · entry 1

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 141,526

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-25-077706 · tm2523328-1_4seq1.xml · derivative · entry 3

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,969

Underlying: Common Stock · 3,984 shares

Expires 2032-02-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The stock options were granted on February 9, 2022. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

SEC source: 0001104659-25-077706 · tm2523328-1_4seq1.xml · nonDerivative · entry 2

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,509

F1 · kind: The sale reported in this Form 4 was effected pursuant to Rule 10b5-1 instruction adopted on August 8, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $90.00 to $90.27 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001104659-25-077706 · tm2523328-1_4seq1.xml · nonDerivative · entry 1

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,493

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-25-071849 · tm2522015-1_4seq1.xml · nonDerivative · entry 2

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,814

F2 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 instruction adopted prior to February 27, 2023 solely with the intent to cover withholding taxes in connection with the vesting of certain previously reported restricted stock units.

SEC source: 0001104659-25-071849 · tm2522015-1_4seq1.xml · derivative · entry 3

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,125 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F3 · derivative.exercise_date: The restricted stock units vest as to 25% of the total shares on each of July 26, 2022, July 26, 2023, July 26, 2024 and July 26, 2025. The restricted stock units have no expiration date.

F3 · derivative.expiration_date: The restricted stock units vest as to 25% of the total shares on each of July 26, 2022, July 26, 2023, July 26, 2024 and July 26, 2025. The restricted stock units have no expiration date.

SEC source: 0001104659-25-071849 · tm2522015-1_4seq1.xml · nonDerivative · entry 1

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 22,334

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

SEC source: 0001104659-25-067427 · tm2520691-1_4seq1.xml · derivative · entry 7

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,075

Underlying: Common Stock · 5,025 shares

Expires 2033-01-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The stock options were granted on February 1, 2023. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

SEC source: 0001104659-25-067427 · tm2520691-1_4seq1.xml · derivative · entry 6

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 17,581

Underlying: Common Stock · 10,547 shares

Expires 2032-02-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The stock options were granted on February 9, 2022. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

SEC source: 0001104659-25-067427 · tm2520691-1_4seq1.xml · nonDerivative · entry 5

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 19,209

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 16, 2024.

SEC source: 0001104659-25-067427 · tm2520691-1_4seq1.xml · nonDerivative · entry 4

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 22,725

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 16, 2024.

F3 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $76.17 to $76.75 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001104659-25-067427 · tm2520691-1_4seq1.xml · nonDerivative · entry 3

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 30,556

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 16, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $75.08 to $75.98 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001104659-25-067427 · tm2520691-1_4seq1.xml · nonDerivative · entry 2

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 34,781

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-25-067427 · tm2520691-1_4seq1.xml · nonDerivative · entry 1

Cramer Pamela J. · CIK 0001873517 · Chief Human Resources Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 29,756

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-25-067428 · tm2520691-2_4seq1.xml · derivative · entry 6

German Christopher Paul · CIK 0001260835 · Corporate Controller & CAO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,550

Underlying: Common Stock · 850 shares

Expires 2034-02-15

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The stock options were granted on February 16, 2024. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

SEC source: 0001104659-25-067428 · tm2520691-2_4seq1.xml · derivative · entry 5

German Christopher Paul · CIK 0001260835 · Corporate Controller & CAO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,231

Underlying: Common Stock · 2,000 shares

Expires 2033-04-03

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The stock options were granted on April 4, 2023. The options vest and become exercisable as to 25% of the total shares on March 20, 2024 and, thereafter, as to the remaining 75% of the total shares in twelve equal quarterly installments of 6.25% beginning June 20, 2024 and ending March 20, 2027, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0001104659-25-067428 · tm2520691-2_4seq1.xml · nonDerivative · entry 4

German Christopher Paul · CIK 0001260835 · Corporate Controller & CAO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 922

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 11, 2025.

SEC source: 0001104659-25-067428 · tm2520691-2_4seq1.xml · nonDerivative · entry 3

German Christopher Paul · CIK 0001260835 · Corporate Controller & CAO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,772

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 11, 2025.

SEC source: 0001104659-25-067428 · tm2520691-2_4seq1.xml · nonDerivative · entry 2

German Christopher Paul · CIK 0001260835 · Corporate Controller & CAO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,739

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-25-067428 · tm2520691-2_4seq1.xml · nonDerivative · entry 1

German Christopher Paul · CIK 0001260835 · Corporate Controller & CAO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,889

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-25-067431 · tm2520691-4_4seq1.xml · derivative · entry 5

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 28,088

Underlying: Common Stock · 42,120 shares

Expires 2027-08-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The stock option is fully vested.

SEC source: 0001104659-25-067431 · tm2520691-4_4seq1.xml · nonDerivative · entry 4

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 116,915

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

SEC source: 0001104659-25-067431 · tm2520691-4_4seq1.xml · nonDerivative · entry 3

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 140,315

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

F3 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $76.17 to $76.18 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001104659-25-067431 · tm2520691-4_4seq1.xml · nonDerivative · entry 2

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 141,922

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

F2 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $75.01 to $75.70 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001104659-25-067431 · tm2520691-4_4seq1.xml · nonDerivative · entry 1

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 159,035

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-25-067430 · tm2520691-3_4seq1.xml · derivative · entry 4

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 11,953

Underlying: Common Stock · 7,969 shares

Expires 2032-02-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The stock options were granted on February 9, 2022. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

SEC source: 0001104659-25-067430 · tm2520691-3_4seq1.xml · nonDerivative · entry 3

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,509

F1 · kind: The sale reported in this Form 4 was effected pursuant to Rule 10b5-1 instruction adopted on August 8, 2024.

SEC source: 0001104659-25-067430 · tm2520691-3_4seq1.xml · nonDerivative · entry 2

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,494

F1 · kind: The sale reported in this Form 4 was effected pursuant to Rule 10b5-1 instruction adopted on August 8, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $75.12 to $75.92 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001104659-25-067430 · tm2520691-3_4seq1.xml · nonDerivative · entry 1

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 16,478

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-25-066420 · tm2520047-1_4seq1.xml · derivative · entry 2

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 70,208

Underlying: Common Stock · 6,986 shares

Expires 2027-08-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The stock option is fully vested.

SEC source: 0001104659-25-066420 · tm2520047-1_4seq1.xml · nonDerivative · entry 1

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 116,915

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-25-065844 · tm2519881-1_4seq1.xml · nonDerivative · entry 3

Garfield Alastair · CIK 0002027261 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,126

F2 · kind: The sale reported in this Form 4 was effected pursuant to Rule 10b5-1 instruction adopted on June 25, 2024 solely with the intent to cover withholding taxes in connection with the vesting of certain previously reported restricted stock units.

SEC source: 0001104659-25-065844 · tm2519881-1_4seq1.xml · nonDerivative · entry 2

Garfield Alastair · CIK 0002027261 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,132

F2 · kind: The sale reported in this Form 4 was effected pursuant to Rule 10b5-1 instruction adopted on June 25, 2024 solely with the intent to cover withholding taxes in connection with the vesting of certain previously reported restricted stock units.

SEC source: 0001104659-25-065844 · tm2519881-1_4seq1.xml · derivative · entry 4

Garfield Alastair · CIK 0002027261 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 13,333

Underlying: Common Stock · 4,445 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F3 · derivative.exercise_date: The restricted stock units vest as to 25% of the total restricted stock units on each of the first four anniversaries of July 1, 2024, subject to the Reporting Person's continued service on each such vesting date. The restricted stock units have no expiration date.

F3 · derivative.expiration_date: The restricted stock units vest as to 25% of the total restricted stock units on each of the first four anniversaries of July 1, 2024, subject to the Reporting Person's continued service on each such vesting date. The restricted stock units have no expiration date.

SEC source: 0001104659-25-065844 · tm2519881-1_4seq1.xml · nonDerivative · entry 1

Garfield Alastair · CIK 0002027261 · Chief Scientific Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,445

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

SEC source: 0001104659-25-063076 · tm2519230-6_4seq1.xml · derivative · entry 2

GOOD JENNIFER L · CIK 0001229245 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,712

Underlying: Common Stock · 4,712 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F3 · derivative.exercise_date: The restricted stock units fully vest upon the earlier of (i) June 24, 2026 or (ii) the day immediately prior to the date of the Issuer's next annual meeting of the stockholders to be held in 2026, subject to the Reporting Person's continued service on such vesting date. The restricted stock units have no expiration date.

F3 · derivative.expiration_date: The restricted stock units fully vest upon the earlier of (i) June 24, 2026 or (ii) the day immediately prior to the date of the Issuer's next annual meeting of the stockholders to be held in 2026, subject to the Reporting Person's continued service on such vesting date. The restricted stock units have no expiration date.

SEC source: 0001104659-25-063076 · tm2519230-6_4seq1.xml · derivative · entry 1

GOOD JENNIFER L · CIK 0001229245 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,037

Underlying: Common Stock · 7,037 shares

Expires 2035-06-23

F1 · derivative.exercise_date: The options fully vest upon the earlier of (i) June 24, 2026 or (ii) the day immediately prior to the date of the Issuer's next annual meeting of the stockholders to be held in 2026, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001104659-25-063064 · tm2519230-1_4seq1.xml · derivative · entry 2

MCGIRR DAVID W J · CIK 0001219023 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,712

Underlying: Common Stock · 4,712 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F3 · derivative.exercise_date: The restricted stock units fully vest upon the earlier of (i) June 24, 2026 or (ii) the day immediately prior to the date of the Issuer's next annual meeting of the stockholders to be held in 2026, subject to the Reporting Person's continued service on such vesting date. The restricted stock units have no expiration date.

F3 · derivative.expiration_date: The restricted stock units fully vest upon the earlier of (i) June 24, 2026 or (ii) the day immediately prior to the date of the Issuer's next annual meeting of the stockholders to be held in 2026, subject to the Reporting Person's continued service on such vesting date. The restricted stock units have no expiration date.

SEC source: 0001104659-25-063064 · tm2519230-1_4seq1.xml · derivative · entry 1

MCGIRR DAVID W J · CIK 0001219023 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,037

Underlying: Common Stock · 7,037 shares

Expires 2035-06-23

F1 · derivative.exercise_date: The options fully vest upon the earlier of (i) June 24, 2026 or (ii) the day immediately prior to the date of the Issuer's next annual meeting of the stockholders to be held in 2026, subject to the Reporting Person's continued service on such vesting date.

SEC source: 0001104659-25-063080 · tm2519230-3_4seq1.xml · derivative · entry 2

Bedrosian Camille L · CIK 0001326969 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,712

Underlying: Common Stock · 4,712 shares

Expires not disclosed

F2 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F3 · derivative.exercise_date: The restricted stock units fully vest upon the earlier of (i) June 24, 2026 or (ii) the day immediately prior to the date of the Issuer's next annual meeting of the stockholders to be held in 2026, subject to the Reporting Person's continued service on such vesting date. The restricted stock units have no expiration date.

F3 · derivative.expiration_date: The restricted stock units fully vest upon the earlier of (i) June 24, 2026 or (ii) the day immediately prior to the date of the Issuer's next annual meeting of the stockholders to be held in 2026, subject to the Reporting Person's continued service on such vesting date. The restricted stock units have no expiration date.

SEC source: 0001104659-25-063080 · tm2519230-3_4seq1.xml · derivative · entry 1

Bedrosian Camille L · CIK 0001326969 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,037

Underlying: Common Stock · 7,037 shares

Expires 2035-06-23

F1 · derivative.exercise_date: The options fully vest upon the earlier of (i) June 24, 2026 or (ii) the day immediately prior to the date of the Issuer's next annual meeting of the stockholders to be held in 2026, subject to the Reporting Person's continued service on such vesting date.