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person · Reporting owner

Smith Hunter C

Disclosed activity across 3 companies

Tapewire entity
17845
SEC CIK
0001636385

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Reported relationships

Latest disclosed role at each company.

CompanyLast reported asReport datePublished
RHYTHM PHARMACEUTICALS, INC.RYTM · Entity 3693Chief Financial OfficerAugust 31, 2026September 01, 2026
Spyre Therapeutics, Inc.AGLE · Entity 2649DirectorJune 22, 2023June 30, 2023

Disclosed balances

About these balances

Latest available filing per company, not a reconstructed current portfolio. Matching sequences show the last reported balance with all source rows expandable; grouping alone does not establish account ownership. Do not add unresolved positions together. Filings may omit unchanged positions, and amendments may correct only part of an older disclosure. Jointly reported shares are not necessarily this owner's personal holdings.

RHYTHM PHARMACEUTICALS, INC.

Report date August 31, 2026 · Filed September 01, 2026

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Common StockSEC Table I · non-derivativeDirect114,024 Ending reported balance After 2026-08-31 transaction · row 4
4 source rows · reconciled sequence

Row 1 · 2026-08-31 · Exercise / conversion · Acquired 57,187 · Balance 176,798

F1: The exercise and sales reported in this form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 13, 2026.

Row 2 · 2026-08-31 · Sale · Disposed 23,072 · Balance 153,726

F1: The exercise and sales reported in this form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 13, 2026.

F2: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $104.04 to $105.03 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Row 3 · 2026-08-31 · Sale · Disposed 11,514 · Balance 142,212

F1: The exercise and sales reported in this form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 13, 2026.

F3: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $105.04 to $106.01 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Row 4 · 2026-08-31 · Sale · Disposed 28,188 · Balance 114,024

F1: The exercise and sales reported in this form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 13, 2026.

F4: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $106.05 to $106.88 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Employee Stock Option (Right to Buy)SEC Table II · derivative / convertible security · Conversion / exercise price $25.79 · Expires 2028-02-13Direct3,813 Reported balance After 2026-08-31 transaction · row 5 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 5 · 2026-08-31 · Exercise / conversion · Disposed 57,187 · Balance 3,813

F1: The exercise and sales reported in this form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 13, 2026.

F5: This option was granted on February 14, 2018 and the shares underlying this option vested in sixteen equal quarterly installments.

Filing footnotes · ownership attribution and instrument terms

F1: The exercise and sales reported in this form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 13, 2026.

F2: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $104.04 to $105.03 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F3: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $105.04 to $106.01 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F4: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $106.05 to $106.88 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F5: This option was granted on February 14, 2018 and the shares underlying this option vested in sixteen equal quarterly installments.

Spyre Therapeutics, Inc.

Report date June 22, 2023 · Filed June 30, 2023

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Stock Option (right to buy)SEC Table II · derivative / convertible security · Conversion / exercise price $0.30 · Expires 2033-06-22Direct1,950,000 Reported balance After 2023-06-22 transaction · row 1 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 1 · 2023-06-22 · Grant · Acquired 1,950,000 · Balance 1,950,000

F1: This option award is contingent upon receiving stockholder approval of the amendment and/or restatement of the 2016 Equity Incentive Plan to increase the number of shares available for issuance thereunder.

F2: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on July 22, 2023, or on the date of the next annual meeting of stockholders, if earlier, subject to the continuing service of the Reporting Person on each vesting date.

Filing footnotes · ownership attribution and instrument terms

F1: This option award is contingent upon receiving stockholder approval of the amendment and/or restatement of the 2016 Equity Incentive Plan to increase the number of shares available for issuance thereunder.

F2: The stock option vests and becomes exercisable in 12 equal monthly installments beginning on July 22, 2023, or on the date of the next annual meeting of stockholders, if earlier, subject to the continuing service of the Reporting Person on each vesting date.

Past disclosures · reporting ended (1)

No longer tracked through insider filings. These historical balances do not imply present ownership or a zero position.

GENESEE & WYOMING INC

Report date December 30, 2019 · Filed December 30, 2019

Section 16 reporting ended · disclosed 2019-12-30. Current position is not established by this disclosure.

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Class A Common Stock, $.01 par valueSEC Table I · non-derivativeDirect0 Reported balance After 2019-12-30 transaction · row 1
1 source row

Row 1 · 2019-12-30 · Disposition to issuer · Disposed 11,824 · Balance 0

F1: On December 30, 2019, in connection with the acquisition of Genesee & Wyoming Inc. ("G&W") by Brookfield Infrastructure and GIC, pursuant to an Agreement and Plan of Merger, dated as of July 1, 2019, among G&W, DJP XX, LLC ("Parent") and MKM XXII Corp. ("Merger Sub"), Merger Sub was merged with and into G&W (the "Merger") with G&W surviving the Merger as a wholly-owned subsidiary of Parent. Pursuant to the Merger Agreement, upon completion of the Merger, each share of G&W common stock (other than certain excluded shares) was converted into the right to receive $112.00 in cash (the "Merger Consideration") and time-based vesting conditions of each unvested deferred stock unit, restricted stock unit, phantom stock unit, restricted share or similar stock right ("Stock Units") were deemed satisfied and accelerated in full and each Stock Unit was cancelled and entitled the holder to receive the Merger Consideration.

F2: Included in the table above are a total of 2,275 Stock Units which were accelerated in connection with the Merger.

Filing footnotes · ownership attribution and instrument terms

F1: On December 30, 2019, in connection with the acquisition of Genesee & Wyoming Inc. ("G&W") by Brookfield Infrastructure and GIC, pursuant to an Agreement and Plan of Merger, dated as of July 1, 2019, among G&W, DJP XX, LLC ("Parent") and MKM XXII Corp. ("Merger Sub"), Merger Sub was merged with and into G&W (the "Merger") with G&W surviving the Merger as a wholly-owned subsidiary of Parent. Pursuant to the Merger Agreement, upon completion of the Merger, each share of G&W common stock (other than certain excluded shares) was converted into the right to receive $112.00 in cash (the "Merger Consideration") and time-based vesting conditions of each unvested deferred stock unit, restricted stock unit, phantom stock unit, restricted share or similar stock right ("Stock Units") were deemed satisfied and accelerated in full and each Stock Unit was cancelled and entitled the holder to receive the Merger Consideration.

F2: Included in the table above are a total of 2,275 Stock Units which were accelerated in connection with the Merger.

Transaction history

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateCompanyActivity / securityShares / unitsReported priceReported valueDetails
August 31, 2026 Filed Sep 1, 2026 20:22 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionEmployee Stock Option (Right to Buy) · Derivative 57,187 $0.00 Strike: $25.79 $0.00
Disclosure

SEC source: 0001649904-26-000023 · form4.xml · derivative · entry 5

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,813

Underlying: Common Stock · 57,187 shares

Expires 2028-02-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sales reported in this form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 13, 2026.

F5 · derivative.exercise_date: This option was granted on February 14, 2018 and the shares underlying this option vested in sixteen equal quarterly installments.

Read SEC document
August 31, 2026 Filed Sep 1, 2026 20:22 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 28,188 $106.20 $2,993,647.35
Disclosure

SEC source: 0001649904-26-000023 · form4.xml · nonDerivative · entry 4

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 114,024

F1 · kind: The exercise and sales reported in this form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 13, 2026.

F4 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $106.05 to $106.88 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
August 31, 2026 Filed Sep 1, 2026 20:22 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 11,514 $105.37 $1,213,232.48
Disclosure

SEC source: 0001649904-26-000023 · form4.xml · nonDerivative · entry 3

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 142,212

F1 · kind: The exercise and sales reported in this form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 13, 2026.

F3 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $105.04 to $106.01 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
August 31, 2026 Filed Sep 1, 2026 20:22 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 23,072 $104.59 $2,413,033.57
Disclosure

SEC source: 0001649904-26-000023 · form4.xml · nonDerivative · entry 2

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 153,726

F1 · kind: The exercise and sales reported in this form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 13, 2026.

F2 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $104.04 to $105.03 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
August 31, 2026 Filed Sep 1, 2026 20:22 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 57,187 $25.79 $1,474,852.73
Disclosure

SEC source: 0001649904-26-000023 · form4.xml · nonDerivative · entry 1

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 176,798

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise and sales reported in this form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 13, 2026.

Read SEC document
May 18, 2026 Filed May 20, 2026 20:15 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 3,000 $0.00 Strike: $17.87 $0.00
Disclosure

SEC source: 0001104659-26-064516 · tm2615222-1_4seq1.xml · derivative · entry 2

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 79,000

Underlying: Common Stock · 3,000 shares

Expires 2030-02-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The options are fully vested.

Read SEC document
May 18, 2026 Filed May 20, 2026 20:15 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 3,000 $17.87 $53,610.00
Disclosure

SEC source: 0001104659-26-064516 · tm2615222-1_4seq1.xml · nonDerivative · entry 1

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 119,611

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
March 02, 2026 Filed Mar 3, 2026 01:56 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 6,099 $0.00 Strike: $6.80 $0.00
Disclosure

SEC source: 0001104659-26-022440 · tm267814-1_4seq1.xml · derivative · entry 2

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 91,401

Underlying: Common Stock · 6,099 shares

Expires 2032-02-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The options are fully vested.

Read SEC document
March 02, 2026 Filed Mar 3, 2026 01:56 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 6,099 $6.80 $41,473.20
Disclosure

SEC source: 0001104659-26-022440 · tm267814-1_4seq1.xml · nonDerivative · entry 1

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 116,611

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
February 19, 2026 Filed Feb 20, 2026 02:02 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 585 $103.28 $60,420.44
Disclosure

SEC source: 0001104659-26-017729 · tm266887-1_4seq1.xml · nonDerivative · entry 9

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 110,512

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

F9 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $103.09 to $103.50 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
February 19, 2026 Filed Feb 20, 2026 02:02 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 800 $102.10 $81,676.08
Disclosure

SEC source: 0001104659-26-017729 · tm266887-1_4seq1.xml · nonDerivative · entry 8

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 111,097

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

F8 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $101.57 to $102.36 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
February 19, 2026 Filed Feb 20, 2026 02:02 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 1,692 $100.92 $170,754.78
Disclosure

SEC source: 0001104659-26-017729 · tm266887-1_4seq1.xml · nonDerivative · entry 7

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 111,897

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

F7 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $100.57 to $101.55 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
February 19, 2026 Filed Feb 20, 2026 02:02 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 1,308 $100.27 $131,152.90
Disclosure

SEC source: 0001104659-26-017729 · tm266887-1_4seq1.xml · nonDerivative · entry 6

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 113,589

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

F6 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $99.55 to $100.54 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
February 17, 2026 Filed Feb 20, 2026 02:02 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 200 $103.84 $20,768.00
Disclosure

SEC source: 0001104659-26-017729 · tm266887-1_4seq1.xml · nonDerivative · entry 5

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 114,897

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

Read SEC document
February 17, 2026 Filed Feb 20, 2026 02:02 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 1,069 $103.00 $110,109.57
Disclosure

SEC source: 0001104659-26-017729 · tm266887-1_4seq1.xml · nonDerivative · entry 4

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 115,097

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

F5 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $102.52 to $103.43 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
February 17, 2026 Filed Feb 20, 2026 02:02 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 900 $101.70 $91,530.00
Disclosure

SEC source: 0001104659-26-017729 · tm266887-1_4seq1.xml · nonDerivative · entry 3

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 116,166

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

F4 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $101.45 to $101.88 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
February 17, 2026 Filed Feb 20, 2026 02:02 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 200 $100.52 $20,104.00
Disclosure

SEC source: 0001104659-26-017729 · tm266887-1_4seq1.xml · nonDerivative · entry 2

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 117,066

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

F3 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $100.34 to $100.70 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
February 17, 2026 Filed Feb 20, 2026 02:02 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 1,200 $99.42 $119,298.00
Disclosure

SEC source: 0001104659-26-017729 · tm266887-1_4seq1.xml · nonDerivative · entry 1

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 117,266

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

F2 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $99.25 to $99.87 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
February 12, 2026 Filed Feb 13, 2026 01:56 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 100 $100.10 $10,010.00
Disclosure

SEC source: 0001104659-26-014546 · tm266263-1_4seq1.xml · nonDerivative · entry 10

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 118,466

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

Read SEC document
February 12, 2026 Filed Feb 13, 2026 01:56 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 800 $98.99 $79,192.48
Disclosure

SEC source: 0001104659-26-014546 · tm266263-1_4seq1.xml · nonDerivative · entry 9

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 118,566

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

F9 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $98.54 to $99.40 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
February 12, 2026 Filed Feb 13, 2026 01:56 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 400 $97.67 $39,068.52
Disclosure

SEC source: 0001104659-26-014546 · tm266263-1_4seq1.xml · nonDerivative · entry 8

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 119,366

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

F8 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $97.18 to $97.85 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
February 12, 2026 Filed Feb 13, 2026 01:56 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 292 $96.26 $28,108.71
Disclosure

SEC source: 0001104659-26-014546 · tm266263-1_4seq1.xml · nonDerivative · entry 7

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 119,766

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

F7 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $96.04 to $96.58 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
February 11, 2026 Filed Feb 13, 2026 01:56 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 GrantStock Options (Right to Buy) · Derivative 37,500 $0.00 Strike: $98.47 $0.00
Disclosure

SEC source: 0001104659-26-014546 · tm266263-1_4seq1.xml · derivative · entry 12

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 37,500

Underlying: Common Stock · 37,500 shares

Expires 2036-02-10

F12 · derivative.exercise_date: The stock options were granted on February 11, 2026. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

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February 11, 2026 Filed Feb 13, 2026 01:56 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 GrantRestricted Stock Units · Derivative 25,000 $0.00 $0.00
Disclosure

SEC source: 0001104659-26-014546 · tm266263-1_4seq1.xml · derivative · entry 11

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires not disclosed

F10 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F11 · derivative.exercise_date: The restricted stock units vest as to 25% of the total shares on each of February 1, 2027, February 1, 2028, February 1, 2029 and February 1, 2030. The restricted stock units have no expiration date.

F11 · derivative.expiration_date: The restricted stock units vest as to 25% of the total shares on each of February 1, 2027, February 1, 2028, February 1, 2029 and February 1, 2030. The restricted stock units have no expiration date.

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February 11, 2026 Filed Feb 13, 2026 01:56 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 100 $100.85 $10,085.27
Disclosure

SEC source: 0001104659-26-014546 · tm266263-1_4seq1.xml · nonDerivative · entry 6

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 120,058

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

F6 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $100.49 to $100.98 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

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February 11, 2026 Filed Feb 13, 2026 01:56 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 400 $99.44 $39,774.72
Disclosure

SEC source: 0001104659-26-014546 · tm266263-1_4seq1.xml · nonDerivative · entry 5

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 120,158

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

F5 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $98.89 to $99.88 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

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February 11, 2026 Filed Feb 13, 2026 01:56 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 2,266 $98.37 $222,906.42
Disclosure

SEC source: 0001104659-26-014546 · tm266263-1_4seq1.xml · nonDerivative · entry 4

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 120,558

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

F4 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $97.80 to $98.79 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

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February 10, 2026 Filed Feb 13, 2026 01:56 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 100 $104.76 $10,476.00
Disclosure

SEC source: 0001104659-26-014546 · tm266263-1_4seq1.xml · nonDerivative · entry 3

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 122,824

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

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February 10, 2026 Filed Feb 13, 2026 01:56 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 700 $103.68 $72,573.69
Disclosure

SEC source: 0001104659-26-014546 · tm266263-1_4seq1.xml · nonDerivative · entry 2

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 122,924

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

F3 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $103.23 to $103.98 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

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February 10, 2026 Filed Feb 13, 2026 01:56 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 1,913 $102.66 $196,379.78
Disclosure

SEC source: 0001104659-26-014546 · tm266263-1_4seq1.xml · nonDerivative · entry 1

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 123,624

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

F2 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $$102.09 to $103.02 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

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February 05, 2026 Filed Feb 6, 2026 23:38 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 3,381 $106.06 $358,599.00
Disclosure

SEC source: 0001104659-26-011651 · tm265467-1_4seq1.xml · nonDerivative · entry 4

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 125,537

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

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February 04, 2026 Filed Feb 6, 2026 23:38 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 747 $107.67 $80,426.05
Disclosure

SEC source: 0001104659-26-011651 · tm265467-1_4seq1.xml · nonDerivative · entry 3

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 128,918

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

F4 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $107.32 to $108.08 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

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February 04, 2026 Filed Feb 6, 2026 23:38 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 1,000 $106.60 $106,604.00
Disclosure

SEC source: 0001104659-26-011651 · tm265467-1_4seq1.xml · nonDerivative · entry 2

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 129,665

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

F3 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $106.31 to $107.15 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

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February 04, 2026 Filed Feb 6, 2026 23:38 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 1,500 $104.74 $157,115.10
Disclosure

SEC source: 0001104659-26-011651 · tm265467-1_4seq1.xml · nonDerivative · entry 1

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 130,665

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

F2 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $104.34 to $104.99 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

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February 01, 2026 Filed Feb 3, 2026 21:36 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionRestricted Stock Units · Derivative 10,413 $0.00 $0.00
Disclosure

SEC source: 0001104659-26-009770 · tm264963-8_4seq1.xml · derivative · entry 6

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,237

Underlying: Common Stock · 10,413 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F6 · derivative.exercise_date: The restricted stock units vest as to 25% of the total shares on each of February 1, 2026, February 1, 2027, February 1, 2028 and February 1, 2029. The restricted stock units have no expiration date.

F6 · derivative.expiration_date: The restricted stock units vest as to 25% of the total shares on each of February 1, 2026, February 1, 2027, February 1, 2028 and February 1, 2029. The restricted stock units have no expiration date.

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February 01, 2026 Filed Feb 3, 2026 21:36 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionRestricted Stock Units · Derivative 6,600 $0.00 $0.00
Disclosure

SEC source: 0001104659-26-009770 · tm264963-8_4seq1.xml · derivative · entry 5

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,200

Underlying: Common Stock · 6,600 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F5 · derivative.exercise_date: The restricted stock units vest as to 25% of the total shares on each of February 16, 2025, February 1, 2026, February 1, 2027 and February 1, 2028. The restricted stock units have no expiration date.

F5 · derivative.expiration_date: The restricted stock units vest as to 25% of the total shares on each of February 16, 2025, February 1, 2026, February 1, 2027 and February 1, 2028. The restricted stock units have no expiration date.

Read SEC document
February 01, 2026 Filed Feb 3, 2026 21:36 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionRestricted Stock Units · Derivative 4,925 $0.00 $0.00
Disclosure

SEC source: 0001104659-26-009770 · tm264963-8_4seq1.xml · derivative · entry 4

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,925

Underlying: Common Stock · 4,925 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F4 · derivative.exercise_date: The restricted stock units vest as to 25% of the total shares on each of February 1, 2024, February 1, 2025, February 1, 2026 and February 1, 2027. The restricted stock units have no expiration date.

F4 · derivative.expiration_date: The restricted stock units vest as to 25% of the total shares on each of February 1, 2024, February 1, 2025, February 1, 2026 and February 1, 2027. The restricted stock units have no expiration date.

Read SEC document
February 01, 2026 Filed Feb 3, 2026 21:36 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionRestricted Stock Units · Derivative 4,062 $0.00 $0.00
Disclosure

SEC source: 0001104659-26-009770 · tm264963-8_4seq1.xml · derivative · entry 3

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 4,062 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F3 · derivative.exercise_date: The restricted stock units vest as to 25% of the total shares on each of February 9, 2023, February 9, 2024, February 9, 2025 and February 1, 2026. The restricted stock units have no expiration date.

F3 · derivative.expiration_date: The restricted stock units vest as to 25% of the total shares on each of February 9, 2023, February 9, 2024, February 9, 2025 and February 1, 2026. The restricted stock units have no expiration date.

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February 01, 2026 Filed Feb 3, 2026 21:36 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Tax withholdingCommon Stock 10,750 $108.99 $1,171,642.50
Disclosure

SEC source: 0001104659-26-009770 · tm264963-8_4seq1.xml · nonDerivative · entry 2

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 132,165

F2 · kind: These shares were withheld for payment of the withholding taxes upon the vesting of the restricted stock units reported herein.

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February 01, 2026 Filed Feb 3, 2026 21:36 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 26,000 Not disclosed Not disclosed
Disclosure

SEC source: 0001104659-26-009770 · tm264963-8_4seq1.xml · nonDerivative · entry 1

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 142,915

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

Read SEC document
August 13, 2025 Filed Aug 14, 2025 22:48 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 3,477 $0.00 Strike: $6.88 $0.00
Disclosure

SEC source: 0001104659-25-078815 · tm2523328-3_4seq1.xml · derivative · entry 6

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,477 shares

Expires 2027-08-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The stock option is fully vested.

Read SEC document
August 13, 2025 Filed Aug 14, 2025 22:48 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 3,477 $96.00 $333,792.00
Disclosure

SEC source: 0001104659-25-078815 · tm2523328-3_4seq1.xml · nonDerivative · entry 4

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 116,915

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

Read SEC document
August 13, 2025 Filed Aug 14, 2025 22:48 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 3,477 $6.88 $23,921.76
Disclosure

SEC source: 0001104659-25-078815 · tm2523328-3_4seq1.xml · nonDerivative · entry 3

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 120,392

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
August 12, 2025 Filed Aug 14, 2025 22:48 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 24,611 $0.00 Strike: $6.88 $0.00
Disclosure

SEC source: 0001104659-25-078815 · tm2523328-3_4seq1.xml · derivative · entry 5

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,477

Underlying: Common Stock · 24,611 shares

Expires 2027-08-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The stock option is fully vested.

Read SEC document
August 12, 2025 Filed Aug 14, 2025 22:48 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 24,611 $96.33 $2,370,831.77
Disclosure

SEC source: 0001104659-25-078815 · tm2523328-3_4seq1.xml · nonDerivative · entry 2

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 116,915

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

F2 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $96.00 to $96.63 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

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August 12, 2025 Filed Aug 14, 2025 22:48 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 24,611 $6.88 $169,323.68
Disclosure

SEC source: 0001104659-25-078815 · tm2523328-3_4seq1.xml · nonDerivative · entry 1

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 141,526

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
July 09, 2025 Filed Jul 11, 2025 20:31 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 42,120 $0.00 Strike: $6.88 $0.00
Disclosure

SEC source: 0001104659-25-067431 · tm2520691-4_4seq1.xml · derivative · entry 5

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 28,088

Underlying: Common Stock · 42,120 shares

Expires 2027-08-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The stock option is fully vested.

Read SEC document
July 09, 2025 Filed Jul 11, 2025 20:31 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 23,400 $84.50 $1,977,300.00
Disclosure

SEC source: 0001104659-25-067431 · tm2520691-4_4seq1.xml · nonDerivative · entry 4

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 116,915

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

Read SEC document
July 09, 2025 Filed Jul 11, 2025 20:31 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 1,607 $76.17 $122,406.31
Disclosure

SEC source: 0001104659-25-067431 · tm2520691-4_4seq1.xml · nonDerivative · entry 3

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 140,315

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

F3 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $76.17 to $76.18 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
July 09, 2025 Filed Jul 11, 2025 20:31 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 17,113 $75.38 $1,290,049.81
Disclosure

SEC source: 0001104659-25-067431 · tm2520691-4_4seq1.xml · nonDerivative · entry 2

Smith Hunter C · CIK 0001636385 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 141,922

F1 · kind: The sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 plan adopted by the Reporting Person on February 28, 2025.

F2 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $75.01 to $75.70 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document

Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.