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Shulman Joseph

Disclosed activity across 1 company

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22763
SEC CIK
0001909855

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CompanyLast reported asReport datePublished
RHYTHM PHARMACEUTICALS, INC.RYTM · Entity 3693Chief Technical OfficerAugust 13, 2026August 17, 2026

Disclosed balances

About these balances

Latest available filing per company, not a reconstructed current portfolio. Matching sequences show the last reported balance with all source rows expandable; grouping alone does not establish account ownership. Do not add unresolved positions together. Filings may omit unchanged positions, and amendments may correct only part of an older disclosure. Jointly reported shares are not necessarily this owner's personal holdings.

RHYTHM PHARMACEUTICALS, INC.

Report date August 13, 2026 · Filed August 17, 2026

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Common StockSEC Table I · non-derivativeDirect15,915 Ending reported balance After 2026-08-13 transaction · row 2
2 source rows · reconciled sequence

Row 1 · 2026-08-13 · Exercise / conversion · Acquired 2,024 · Balance 20,994

F1: The Exercise and sale reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 15, 2025.

Row 2 · 2026-08-13 · Sale · Disposed 5,079 · Balance 15,915

F1: The Exercise and sale reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 15, 2025.

Stock Options (Right to Buy)SEC Table II · derivative / convertible security · Conversion / exercise price $6.80 · Expires 2032-02-08Direct5,945 Reported balance After 2026-08-13 transaction · row 3 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 3 · 2026-08-13 · Exercise / conversion · Disposed 2,024 · Balance 5,945

F1: The Exercise and sale reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 15, 2025.

F2: The stock options were granted on February 9, 2022. The options vested and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

Filing footnotes · ownership attribution and instrument terms

F1: The Exercise and sale reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 15, 2025.

F2: The stock options were granted on February 9, 2022. The options vested and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

Transaction history

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateCompanyActivity / securityShares / unitsReported priceReported valueDetails
August 13, 2026 Filed Aug 17, 2026 22:00 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 2,024 $0.00 Strike: $6.80 $0.00
Disclosure

SEC source: 0001649904-26-000015 · form4.xml · derivative · entry 3

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,945

Underlying: Common Stock · 2,024 shares

Expires 2032-02-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The Exercise and sale reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 15, 2025.

F2 · derivative.exercise_date: The stock options were granted on February 9, 2022. The options vested and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

Read SEC document
August 13, 2026 Filed Aug 17, 2026 22:00 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 5,079 $119.75 $608,210.25
Disclosure

SEC source: 0001649904-26-000015 · form4.xml · nonDerivative · entry 2

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,915

F1 · kind: The Exercise and sale reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 15, 2025.

Read SEC document
August 13, 2026 Filed Aug 17, 2026 22:00 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 2,024 $6.80 $13,763.20
Disclosure

SEC source: 0001649904-26-000015 · form4.xml · nonDerivative · entry 1

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,994

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The Exercise and sale reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 15, 2025.

Read SEC document
February 11, 2026 Filed Feb 13, 2026 22:53 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 GrantStock Options (Right to Buy) · Derivative 22,500 $0.00 Strike: $98.47 $0.00
Disclosure

SEC source: 0001104659-26-015405 · tm266366-7_4seq1.xml · derivative · entry 2

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,500

Underlying: Common Stock · 22,500 shares

Expires 2036-02-10

F3 · derivative.exercise_date: The stock options were granted on February 11, 2026. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

Read SEC document
February 11, 2026 Filed Feb 13, 2026 22:53 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 GrantRestricted Stock Units · Derivative 15,000 $0.00 $0.00
Disclosure

SEC source: 0001104659-26-015405 · tm266366-7_4seq1.xml · derivative · entry 1

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F2 · derivative.exercise_date: The restricted stock units vest as to 25% of the total shares on each of February 1, 2027, February 1, 2028, February 1, 2029 and February 1, 2030. The restricted stock units have no expiration date.

F2 · derivative.expiration_date: The restricted stock units vest as to 25% of the total shares on each of February 1, 2027, February 1, 2028, February 1, 2029 and February 1, 2030. The restricted stock units have no expiration date.

Read SEC document
February 01, 2026 Filed Feb 3, 2026 21:35 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionRestricted Stock Units · Derivative 6,250 $0.00 $0.00
Disclosure

SEC source: 0001104659-26-009769 · tm264963-7_4seq1.xml · derivative · entry 6

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,750

Underlying: Common Stock · 6,250 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F6 · derivative.exercise_date: The restricted stock units vest as to 25% of the total shares on each of February 1, 2026, February 1, 2027, February 1, 2028 and February 1, 2029. The restricted stock units have no expiration date.

F6 · derivative.expiration_date: The restricted stock units vest as to 25% of the total shares on each of February 1, 2026, February 1, 2027, February 1, 2028 and February 1, 2029. The restricted stock units have no expiration date.

Read SEC document
February 01, 2026 Filed Feb 3, 2026 21:35 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionRestricted Stock Units · Derivative 4,125 $0.00 $0.00
Disclosure

SEC source: 0001104659-26-009769 · tm264963-7_4seq1.xml · derivative · entry 5

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,250

Underlying: Common Stock · 4,125 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F5 · derivative.exercise_date: The restricted stock units vest as to 25% of the total shares on each of February 16, 2025, February 1, 2026, February 1, 2027 and February 1, 2028. The restricted stock units have no expiration date.

F5 · derivative.expiration_date: The restricted stock units vest as to 25% of the total shares on each of February 16, 2025, February 1, 2026, February 1, 2027 and February 1, 2028. The restricted stock units have no expiration date.

Read SEC document
February 01, 2026 Filed Feb 3, 2026 21:35 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionRestricted Stock Units · Derivative 3,937 $0.00 $0.00
Disclosure

SEC source: 0001104659-26-009769 · tm264963-7_4seq1.xml · derivative · entry 4

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,937

Underlying: Common Stock · 3,937 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F4 · derivative.exercise_date: The restricted stock units vest as to 25% of the total shares on each of February 1, 2024, February 1, 2025, February 1, 2026 and February 1, 2027. The restricted stock units have no expiration date.

F4 · derivative.expiration_date: The restricted stock units vest as to 25% of the total shares on each of February 1, 2024, February 1, 2025, February 1, 2026 and February 1, 2027. The restricted stock units have no expiration date.

Read SEC document
February 01, 2026 Filed Feb 3, 2026 21:35 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionRestricted Stock Units · Derivative 2,656 $0.00 $0.00
Disclosure

SEC source: 0001104659-26-009769 · tm264963-7_4seq1.xml · derivative · entry 3

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,656 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F3 · derivative.exercise_date: The restricted stock units vest as to 25% of the total shares on each of February 9, 2023, February 9, 2024, February 9, 2025 and February 1, 2026. The restricted stock units have no expiration date.

F3 · derivative.expiration_date: The restricted stock units vest as to 25% of the total shares on each of February 9, 2023, February 9, 2024, February 9, 2025 and February 1, 2026. The restricted stock units have no expiration date.

Read SEC document
February 01, 2026 Filed Feb 3, 2026 21:35 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Tax withholdingCommon Stock 6,507 $108.99 $709,197.93
Disclosure

SEC source: 0001104659-26-009769 · tm264963-7_4seq1.xml · nonDerivative · entry 2

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,970

F2 · kind: These shares were withheld for payment of the withholding taxes upon the vesting of the restricted stock units reported herein.

Read SEC document
February 01, 2026 Filed Feb 3, 2026 21:35 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 16,968 Not disclosed Not disclosed
Disclosure

SEC source: 0001104659-26-009769 · tm264963-7_4seq1.xml · nonDerivative · entry 1

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,477

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

Read SEC document
October 30, 2025 Filed Nov 3, 2025 21:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 9,748 $0.00 Strike: $30.66 $0.00
Disclosure

SEC source: 0001104659-25-105576 · tm2530076-1_4seq1.xml · derivative · entry 3

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 9,748 shares

Expires 2031-02-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The stock option is fully vested.

Read SEC document
October 30, 2025 Filed Nov 3, 2025 21:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 9,748 $115.24 $1,123,397.54
Disclosure

SEC source: 0001104659-25-105576 · tm2530076-1_4seq1.xml · nonDerivative · entry 2

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,509

F1 · kind: The sale reported in this Form 4 was effected pursuant to Rule 10b5-1 instruction adopted on August 8, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $115.00 to $115.73 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
October 30, 2025 Filed Nov 3, 2025 21:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 9,748 $30.66 $298,873.68
Disclosure

SEC source: 0001104659-25-105576 · tm2530076-1_4seq1.xml · nonDerivative · entry 1

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 18,257

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
October 28, 2025 Filed Oct 30, 2025 20:44 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 721 $0.00 Strike: $30.66 $0.00
Disclosure

SEC source: 0001104659-25-104437 · tm2529785-1_4seq1.xml · derivative · entry 5

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 9,748

Underlying: Common Stock · 721 shares

Expires 2031-02-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The stock option is fully vested.

Read SEC document
October 28, 2025 Filed Oct 30, 2025 20:44 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 2,094 $0.00 Strike: $27.35 $0.00
Disclosure

SEC source: 0001104659-25-104437 · tm2529785-1_4seq1.xml · derivative · entry 4

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,563

Underlying: Common Stock · 2,094 shares

Expires 2033-01-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The stock options were granted on February 1, 2023. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

Read SEC document
October 28, 2025 Filed Oct 30, 2025 20:44 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 2,815 $115.01 $323,750.05
Disclosure

SEC source: 0001104659-25-104437 · tm2529785-1_4seq1.xml · nonDerivative · entry 3

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,509

F1 · kind: The sale reported in this Form 4 was effected pursuant to Rule 10b5-1 instruction adopted on August 8, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $115.00 to $115.08 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
October 28, 2025 Filed Oct 30, 2025 20:44 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 721 $30.66 $22,105.86
Disclosure

SEC source: 0001104659-25-104437 · tm2529785-1_4seq1.xml · nonDerivative · entry 2

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 11,324

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
October 28, 2025 Filed Oct 30, 2025 20:44 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 2,094 $27.35 $57,270.90
Disclosure

SEC source: 0001104659-25-104437 · tm2529785-1_4seq1.xml · nonDerivative · entry 1

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10,603

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
October 16, 2025 Filed Oct 20, 2025 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 12,344 $0.00 Strike: $30.66 $0.00
Disclosure

SEC source: 0001104659-25-100851 · tm2529018-1_4seq1.xml · derivative · entry 7

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10,469

Underlying: Common Stock · 12,344 shares

Expires 2031-02-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The stock option is fully vested.

Read SEC document
October 16, 2025 Filed Oct 20, 2025 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 2,093 $0.00 Strike: $27.35 $0.00
Disclosure

SEC source: 0001104659-25-100851 · tm2529018-1_4seq1.xml · derivative · entry 6

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 14,657

Underlying: Common Stock · 2,093 shares

Expires 2033-01-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The stock options were granted on February 1, 2023. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

Read SEC document
October 16, 2025 Filed Oct 20, 2025 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 3,412 $112.81 $384,907.72
Disclosure

SEC source: 0001104659-25-100851 · tm2529018-1_4seq1.xml · nonDerivative · entry 5

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,509

F1 · kind: The sale reported in this Form 4 was effected pursuant to Rule 10b5-1 instruction adopted on August 8, 2024.

F4 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $112.51 to $113.14 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
October 16, 2025 Filed Oct 20, 2025 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 8,332 $112.06 $933,645.59
Disclosure

SEC source: 0001104659-25-100851 · tm2529018-1_4seq1.xml · nonDerivative · entry 4

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 11,921

F1 · kind: The sale reported in this Form 4 was effected pursuant to Rule 10b5-1 instruction adopted on August 8, 2024.

F3 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $111.50 to $112.48 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
October 16, 2025 Filed Oct 20, 2025 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 2,693 $110.95 $298,783.50
Disclosure

SEC source: 0001104659-25-100851 · tm2529018-1_4seq1.xml · nonDerivative · entry 3

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,253

F1 · kind: The sale reported in this Form 4 was effected pursuant to Rule 10b5-1 instruction adopted on August 8, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $110.23 to $111.00 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

Read SEC document
October 16, 2025 Filed Oct 20, 2025 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 12,344 $30.66 $378,467.04
Disclosure

SEC source: 0001104659-25-100851 · tm2529018-1_4seq1.xml · nonDerivative · entry 2

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 22,946

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
October 16, 2025 Filed Oct 20, 2025 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 2,093 $27.35 $57,243.55
Disclosure

SEC source: 0001104659-25-100851 · tm2529018-1_4seq1.xml · nonDerivative · entry 1

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10,602

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
September 02, 2025 Filed Sep 4, 2025 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 14,687 $0.00 Strike: $30.66 $0.00
Disclosure

SEC source: 0001104659-25-087487 · tm2525191-1_4seq1.xml · derivative · entry 5

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 22,813

Underlying: Common Stock · 14,687 shares

Expires 2031-02-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The stock options were granted on February 11, 2021. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

Read SEC document
September 02, 2025 Filed Sep 4, 2025 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 2,094 $0.00 Strike: $27.35 $0.00
Disclosure

SEC source: 0001104659-25-087487 · tm2525191-1_4seq1.xml · derivative · entry 4

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 16,750

Underlying: Common Stock · 2,094 shares

Expires 2033-01-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The stock options were granted on February 1, 2023. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

Read SEC document
September 02, 2025 Filed Sep 4, 2025 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 16,781 $105.30 $1,767,005.74
Disclosure

SEC source: 0001104659-25-087487 · tm2525191-1_4seq1.xml · nonDerivative · entry 3

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,509

F1 · kind: The sale reported in this Form 4 was effected pursuant to Rule 10b5-1 instruction adopted on August 8, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $105.00 to $105.82 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

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September 02, 2025 Filed Sep 4, 2025 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 14,687 $30.66 $450,303.42
Disclosure

SEC source: 0001104659-25-087487 · tm2525191-1_4seq1.xml · nonDerivative · entry 2

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,290

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

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September 02, 2025 Filed Sep 4, 2025 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 2,094 $27.35 $57,270.90
Disclosure

SEC source: 0001104659-25-087487 · tm2525191-1_4seq1.xml · nonDerivative · entry 1

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10,603

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

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August 21, 2025 Filed Aug 26, 2025 00:59 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 4,188 $0.00 Strike: $27.35 $0.00
Disclosure

SEC source: 0001104659-25-082668 · tm2524281-1_4seq1.xml · derivative · entry 3

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 18,844

Underlying: Common Stock · 4,188 shares

Expires 2033-01-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The stock options were granted on February 1, 2023. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

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August 21, 2025 Filed Aug 26, 2025 00:59 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 4,188 $100.07 $419,090.65
Disclosure

SEC source: 0001104659-25-082668 · tm2524281-1_4seq1.xml · nonDerivative · entry 2

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,509

F1 · kind: The sale reported in this Form 4 was effected pursuant to Rule 10b5-1 instruction adopted on August 8, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $100.00 to $100.30 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

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August 21, 2025 Filed Aug 26, 2025 00:59 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 4,188 $27.35 $114,541.80
Disclosure

SEC source: 0001104659-25-082668 · tm2524281-1_4seq1.xml · nonDerivative · entry 1

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,697

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
August 11, 2025 Filed Aug 13, 2025 22:32 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 3,984 $0.00 Strike: $6.80 $0.00
Disclosure

SEC source: 0001104659-25-077706 · tm2523328-1_4seq1.xml · derivative · entry 3

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,969

Underlying: Common Stock · 3,984 shares

Expires 2032-02-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The stock options were granted on February 9, 2022. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

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August 11, 2025 Filed Aug 13, 2025 22:32 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 3,984 $90.08 $358,891.47
Disclosure

SEC source: 0001104659-25-077706 · tm2523328-1_4seq1.xml · nonDerivative · entry 2

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,509

F1 · kind: The sale reported in this Form 4 was effected pursuant to Rule 10b5-1 instruction adopted on August 8, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $90.00 to $90.27 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

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August 11, 2025 Filed Aug 13, 2025 22:32 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 3,984 $6.80 $27,091.20
Disclosure

SEC source: 0001104659-25-077706 · tm2523328-1_4seq1.xml · nonDerivative · entry 1

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,493

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
July 09, 2025 Filed Jul 11, 2025 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionStock Options (Right to Buy) · Derivative 7,969 $0.00 Strike: $6.80 $0.00
Disclosure

SEC source: 0001104659-25-067430 · tm2520691-3_4seq1.xml · derivative · entry 4

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 11,953

Underlying: Common Stock · 7,969 shares

Expires 2032-02-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The stock options were granted on February 9, 2022. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

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July 09, 2025 Filed Jul 11, 2025 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 3,985 $80.00 $318,800.00
Disclosure

SEC source: 0001104659-25-067430 · tm2520691-3_4seq1.xml · nonDerivative · entry 3

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,509

F1 · kind: The sale reported in this Form 4 was effected pursuant to Rule 10b5-1 instruction adopted on August 8, 2024.

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July 09, 2025 Filed Jul 11, 2025 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 3,984 $75.56 $301,050.56
Disclosure

SEC source: 0001104659-25-067430 · tm2520691-3_4seq1.xml · nonDerivative · entry 2

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,494

F1 · kind: The sale reported in this Form 4 was effected pursuant to Rule 10b5-1 instruction adopted on August 8, 2024.

F2 · price: The price reported in Column 4 is a weighted average price. The securities were sold in multiple transactions at prices ranging from $75.12 to $75.92 per common stock. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

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July 09, 2025 Filed Jul 11, 2025 20:30 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 7,969 $6.80 $54,189.20
Disclosure

SEC source: 0001104659-25-067430 · tm2520691-3_4seq1.xml · nonDerivative · entry 1

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 16,478

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
February 19, 2025 Filed Feb 20, 2025 02:49 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 1,228 $57.22 $70,266.16
Disclosure

SEC source: 0001104659-25-015324 · tm257103-7_4seq1.xml · nonDerivative · entry 2

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,509

F2 · kind: The sale reported in this Form 4 was effected pursuant to Rule 10b5-1 instruction adopted prior to February 27, 2023 solely with the intent to cover withholding taxes in connection with the vesting of certain previously reported restricted stock units.

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February 16, 2025 Filed Feb 20, 2025 02:49 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionRestricted Stock Units · Derivative 4,125 $0.00 $0.00
Disclosure

SEC source: 0001104659-25-015324 · tm257103-7_4seq1.xml · derivative · entry 5

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,375

Underlying: Common Stock · 4,125 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F5 · derivative.exercise_date: The restricted stock units vest as to 25% of the total shares on each of February 16, 2025, February 16, 2026, February 16, 2027 and February 16, 2028. The restricted stock units have no expiration date.

F5 · derivative.expiration_date: The restricted stock units vest as to 25% of the total shares on each of February 16, 2025, February 16, 2026, February 16, 2027 and February 16, 2028. The restricted stock units have no expiration date.

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February 16, 2025 Filed Feb 20, 2025 02:49 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionCommon Stock 4,125 Not disclosed Not disclosed
Disclosure

SEC source: 0001104659-25-015324 · tm257103-7_4seq1.xml · nonDerivative · entry 1

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 9,737

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

Read SEC document
February 14, 2025 Filed Feb 20, 2025 02:49 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 GrantStock Options (Right to Buy) · Derivative 37,500 $0.00 Strike: $56.69 $0.00
Disclosure

SEC source: 0001104659-25-015324 · tm257103-7_4seq1.xml · derivative · entry 4

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 37,500

Underlying: Common Stock · 37,500 shares

Expires 2035-02-13

F4 · derivative.exercise_date: The stock options were granted on February 14, 2025. The options vest and become exercisable in 16 substantially equal installments upon the Reporting Person's completion of each three full months of successive service to the Issuer following the grant date.

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February 14, 2025 Filed Feb 20, 2025 02:49 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 GrantRestricted Stock Units · Derivative 25,000 $0.00 $0.00
Disclosure

SEC source: 0001104659-25-015324 · tm257103-7_4seq1.xml · derivative · entry 3

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F3 · derivative.exercise_date: The restricted stock units vest as to 25% of the total shares on each of February 14, 2026, February 14, 2027, February 14, 2028 and February 14, 2029. The restricted stock units have no expiration date.

F3 · derivative.expiration_date: The restricted stock units vest as to 25% of the total shares on each of February 14, 2026, February 14, 2027, February 14, 2028 and February 14, 2029. The restricted stock units have no expiration date.

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February 12, 2025 Filed Feb 14, 2025 21:57 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 7 $57.09 $399.63
Disclosure

SEC source: 0001104659-25-014259 · tm256729-2_4seq1.xml · nonDerivative · entry 2

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,612

F1 · kind: The sale reported in this Form 4 was effected pursuant to Rule 10b5-1 instruction adopted prior to February 27, 2023 solely with the intent to cover withholding taxes in connection with the vesting of certain previously reported restricted stock units.

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February 12, 2025 Filed Feb 14, 2025 21:57 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 462 $56.39 $26,052.18
Disclosure

SEC source: 0001104659-25-014259 · tm256729-2_4seq1.xml · nonDerivative · entry 1

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,619

F1 · kind: The sale reported in this Form 4 was effected pursuant to Rule 10b5-1 instruction adopted prior to February 27, 2023 solely with the intent to cover withholding taxes in connection with the vesting of certain previously reported restricted stock units.

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February 11, 2025 Filed Feb 12, 2025 02:47 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 Exercise / conversionRestricted Stock Units · Derivative 1,562 $0.00 $0.00
Disclosure

SEC source: 0001104659-25-011679 · tm256299-4_4seq1.xml · derivative · entry 6

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,562 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit represents a contingent right to receive one share of Issuer common stock.

F4 · derivative.exercise_date: The restricted stock units vest or have vested as to 25% of the total shares on each of February 11, 2022, February 11, 2023, February 11, 2024 and February 11, 2025. The restricted stock units have no expiration date.

F4 · derivative.expiration_date: The restricted stock units vest or have vested as to 25% of the total shares on each of February 11, 2022, February 11, 2023, February 11, 2024 and February 11, 2025. The restricted stock units have no expiration date.

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February 11, 2025 Filed Feb 12, 2025 02:47 UTC RHYTHM PHARMACEUTICALS, INC. RYTM · Entity 3693 SaleCommon Stock 3 $57.54 $172.62
Disclosure

SEC source: 0001104659-25-011679 · tm256299-4_4seq1.xml · nonDerivative · entry 4

Shulman Joseph · CIK 0001909855 · Chief Technical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6.081

F2 · kind: The sale reported in this Form 4 was effected pursuant to Rule 10b5-1 instruction adopted prior to February 27, 2023 solely with the intent to cover withholding taxes in connection with the vesting of certain previously reported restricted stock units.

Read SEC document

Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.