RIGL

SEC source: 0000905148-25-000411 · form4.xml · nonDerivative · entry 1

RODRIGUEZ RAUL R · CIK 0001190279 · Director · CEO, President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 243,854

F1 · kind: These shares were sold to cover tax withholding due upon vesting of Restricted Stock Units. Such "sales to cover" were automatically effected to satisfy tax withholding obligations and do not represent a discretionary trade by the Reporting Person.

SEC source: 0000905148-25-000410 · form4.xml · nonDerivative · entry 1

Furey Raymond J. · CIK 0001577899 · EVP, GC, CCO & Corp Sec

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,169

F1 · kind: These shares were sold to cover tax withholding due upon vesting of Restricted Stock Units. Such "sales to cover" were automatically effected to satisfy tax withholding obligations and do not represent a discretionary trade by the Reporting Person.

SEC source: 0000905148-25-000302 · form4.xml · derivative · entry 2

Rojkjaer Lisa · CIK 0001846460 · EVP, Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,788

Underlying: Common Stock · 14,788 shares

Expires 2035-01-29

F2 · derivative.exercise_date: The shares of common stock subject to the option vest monthly over three (3) years from the vesting commencement date of January 29, 2025, subject to the Reporting Person's continuous service to the Issuer through each such period.

SEC source: 0000905148-25-000302 · form4.xml · nonDerivative · entry 1

Rojkjaer Lisa · CIK 0001846460 · EVP, Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,717

F1 · shares: The shares of common stock are to be acquired upon the vesting of a Restricted Stock Unit award granted to the Reporting Person. The Restricted Stock Units shall vest annually over three (3) years from February 10, 2025, with the first annual vest occurring on February 10, 2026.

SEC source: 0000905148-25-000301 · form4.xml · derivative · entry 2

RODRIGUEZ RAUL R · CIK 0001190279 · Director · CEO, President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 63,400

Underlying: Common Stock · 63,400 shares

Expires 2035-01-29

F2 · derivative.exercise_date: The shares of common stock subject to the option vest monthly over three (3) years from the vesting commencement date of January 29, 2025, subject to the Reporting Person's continuous service to the Issuer through each such period.

SEC source: 0000905148-25-000301 · form4.xml · nonDerivative · entry 1

RODRIGUEZ RAUL R · CIK 0001190279 · Director · CEO, President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 248,806

F1 · shares: The shares of common stock are to be acquired upon the vesting of a Restricted Stock Unit award granted to the Reporting Person. The Restricted Stock Units shall vest annually over three (3) years from February 10, 2025, with the first annual vest occurring on February 10, 2026.

SEC source: 0000905148-25-000299 · form4.xml · derivative · entry 2

Santos David A · CIK 0001820066 · EVP, Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,788

Underlying: Common Stock · 14,788 shares

Expires 2035-01-29

F4 · derivative.exercise_date: The shares of common stock subject to the option vest monthly over three (3) years from the vesting commencement date of January 29, 2025, subject to the Reporting Person's continuous service to the Issuer through each such period.

SEC source: 0000905148-25-000299 · form4.xml · nonDerivative · entry 1

Santos David A · CIK 0001820066 · EVP, Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 55,625

F1 · shares: The shares of common stock are to be acquired upon the vesting of a Restricted Stock Unit award granted to the Reporting Person. The Restricted Stock Units shall vest annually over three (3) years from February 10, 2025, with the first annual vest occurring on February 10, 2026.

F2 · balance_after: This number has been adjusted to reflect the one-for-ten reverse stock split effective June 27, 2024.

F3 · balance_after: Includes 999 shares acquired under the Issuer's stock purchase plan.

SEC source: 0000905148-25-000300 · form4.xml · derivative · entry 2

Schorno Dean L · CIK 0001509688 · EVP & Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,788

Underlying: Common Stock · 14,788 shares

Expires 2035-01-29

F4 · derivative.exercise_date: The shares of common stock subject to the option vest monthly over three (3) years from the vesting commencement date of January 29, 2025, subject to the Reporting Person's continuous service to the Issuer through each such period.

SEC source: 0000905148-25-000300 · form4.xml · nonDerivative · entry 1

Schorno Dean L · CIK 0001509688 · EVP & Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 61,005

F1 · shares: The shares of common stock are to be acquired upon the vesting of a Restricted Stock Unit award granted to the Reporting Person. The Restricted Stock Units shall vest annually over three (3) years from February 10, 2025, with the first annual vest occurring on February 10, 2026.

F2 · balance_after: This number has been adjusted to reflect the one-for-ten reverse stock split effective June 27, 2024.

F3 · balance_after: Includes 999 shares acquired under the Issuer's stock purchase plan.

SEC source: 0000905148-25-000298 · form4.xml · derivative · entry 2

Furey Raymond J. · CIK 0001577899 · EVP, GC, CCO & Corp Sec

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,788

Underlying: Common Stock · 14,788 shares

Expires 2035-01-29

F4 · derivative.exercise_date: The shares of common stock subject to the option vest monthly over three (3) years from the vesting commencement date of January 29, 2025, subject to the Reporting Person's continuous service to the Issuer through each such period.

SEC source: 0000905148-25-000298 · form4.xml · nonDerivative · entry 1

Furey Raymond J. · CIK 0001577899 · EVP, GC, CCO & Corp Sec

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 41,617

F1 · shares: The shares of common stock are to be acquired upon the vesting of a Restricted Stock Unit award granted to the Reporting Person. The Restricted Stock Units shall vest annually over three (3) years from February 10, 2025, with the first annual vest occurring on February 10, 2026.

F2 · balance_after: This number has been adjusted to reflect the one-for-ten reverse stock split effective June 27, 2024.

F3 · balance_after: Includes 500 shares acquired under the Issuer's stock purchase plan.

SEC source: 0000905148-25-000237 · form4.xml · derivative · entry 6

RODRIGUEZ RAUL R · CIK 0001190279 · Director · CEO, President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 45,000 shares

Expires 2025-01-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: These numbers have been adjusted to reflect the one-for-ten reverse stock split effective June 27, 2024.

F1 · shares: These numbers have been adjusted to reflect the one-for-ten reverse stock split effective June 27, 2024.

F1 · derivative.underlying_shares: These numbers have been adjusted to reflect the one-for-ten reverse stock split effective June 27, 2024.

SEC source: 0000905148-25-000237 · form4.xml · derivative · entry 5

RODRIGUEZ RAUL R · CIK 0001190279 · Director · CEO, President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 45,000 shares

Expires 2025-01-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: These numbers have been adjusted to reflect the one-for-ten reverse stock split effective June 27, 2024.

F1 · shares: These numbers have been adjusted to reflect the one-for-ten reverse stock split effective June 27, 2024.

F3 · derivative.exercise_date: The shares vested monthly over two (2) years from January 1, 2015.

F1 · derivative.underlying_shares: These numbers have been adjusted to reflect the one-for-ten reverse stock split effective June 27, 2024.

SEC source: 0000905148-25-000237 · form4.xml · nonDerivative · entry 4

RODRIGUEZ RAUL R · CIK 0001190279 · Director · CEO, President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 206,506

SEC source: 0000905148-25-000237 · form4.xml · nonDerivative · entry 3

RODRIGUEZ RAUL R · CIK 0001190279 · Director · CEO, President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 250,584

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: These numbers have been adjusted to reflect the one-for-ten reverse stock split effective June 27, 2024.

F1 · price: These numbers have been adjusted to reflect the one-for-ten reverse stock split effective June 27, 2024.

SEC source: 0000905148-25-000237 · form4.xml · nonDerivative · entry 2

RODRIGUEZ RAUL R · CIK 0001190279 · Director · CEO, President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 205,584

SEC source: 0000905148-25-000237 · form4.xml · nonDerivative · entry 1

RODRIGUEZ RAUL R · CIK 0001190279 · Director · CEO, President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 249,662

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: These numbers have been adjusted to reflect the one-for-ten reverse stock split effective June 27, 2024.

F1 · price: These numbers have been adjusted to reflect the one-for-ten reverse stock split effective June 27, 2024.

F1 · balance_after: These numbers have been adjusted to reflect the one-for-ten reverse stock split effective June 27, 2024.

F2 · balance_after: Includes 1,000 shares acquired under the Issuer's stock purchase plan.

SEC source: 0000905148-24-003283 · form4.xml · derivative · entry 1

Santos David A · CIK 0001820066 · EVP, Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,000

Underlying: Common Stock · 8,000 shares

Expires 2033-01-26

F1 · derivative.exercise_price: The Reporting Person was granted a stock option with a performance-based condition with respect to 8,000 shares of the Issuer's common stock on January 26, 2023, as adjusted for the one-for-ten reverse stock split effective June 27, 2024 (the "Reverse Stock Split"). The exercise price of this option is $18.70, which is the closing price of the Issuer's common stock on Nasdaq on the date of grant, as adjusted for the Reverse Stock Split. In light of the performance-based vesting condition, this grant was not reportable under Section 16 until the performance metric was satisfied. On November 25, 2024, it was determined that the performance metric had been met.

F1 · shares: The Reporting Person was granted a stock option with a performance-based condition with respect to 8,000 shares of the Issuer's common stock on January 26, 2023, as adjusted for the one-for-ten reverse stock split effective June 27, 2024 (the "Reverse Stock Split"). The exercise price of this option is $18.70, which is the closing price of the Issuer's common stock on Nasdaq on the date of grant, as adjusted for the Reverse Stock Split. In light of the performance-based vesting condition, this grant was not reportable under Section 16 until the performance metric was satisfied. On November 25, 2024, it was determined that the performance metric had been met.

F2 · derivative.exercise_date: The option was fully vested on November 25, 2024, the date the determination was made that the performance metric had been met.

F1 · derivative.underlying_shares: The Reporting Person was granted a stock option with a performance-based condition with respect to 8,000 shares of the Issuer's common stock on January 26, 2023, as adjusted for the one-for-ten reverse stock split effective June 27, 2024 (the "Reverse Stock Split"). The exercise price of this option is $18.70, which is the closing price of the Issuer's common stock on Nasdaq on the date of grant, as adjusted for the Reverse Stock Split. In light of the performance-based vesting condition, this grant was not reportable under Section 16 until the performance metric was satisfied. On November 25, 2024, it was determined that the performance metric had been met.

SEC source: 0000905148-24-003282 · form4.xml · derivative · entry 1

RODRIGUEZ RAUL R · CIK 0001190279 · Director · CEO, President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2033-01-26

F1 · derivative.exercise_price: The Reporting Person was granted a stock option with a performance-based condition with respect to 30,000 shares of the Issuer's common stock on January 26, 2023, as adjusted for the one-for-ten reverse stock split effective June 27, 2024 (the "Reverse Stock Split"). The exercise price of this option is $18.70, which is the closing price of the Issuer's common stock on Nasdaq on the date of grant, as adjusted for the Reverse Stock Split. In light of the performance-based vesting condition, this grant was not reportable under Section 16 until the performance metric was satisfied. On November 25, 2024, it was determined that the performance metric had been met.

F1 · shares: The Reporting Person was granted a stock option with a performance-based condition with respect to 30,000 shares of the Issuer's common stock on January 26, 2023, as adjusted for the one-for-ten reverse stock split effective June 27, 2024 (the "Reverse Stock Split"). The exercise price of this option is $18.70, which is the closing price of the Issuer's common stock on Nasdaq on the date of grant, as adjusted for the Reverse Stock Split. In light of the performance-based vesting condition, this grant was not reportable under Section 16 until the performance metric was satisfied. On November 25, 2024, it was determined that the performance metric had been met.

F2 · derivative.exercise_date: The option was fully vested on November 25, 2024, the date the determination was made that the performance metric had been met.

F1 · derivative.underlying_shares: The Reporting Person was granted a stock option with a performance-based condition with respect to 30,000 shares of the Issuer's common stock on January 26, 2023, as adjusted for the one-for-ten reverse stock split effective June 27, 2024 (the "Reverse Stock Split"). The exercise price of this option is $18.70, which is the closing price of the Issuer's common stock on Nasdaq on the date of grant, as adjusted for the Reverse Stock Split. In light of the performance-based vesting condition, this grant was not reportable under Section 16 until the performance metric was satisfied. On November 25, 2024, it was determined that the performance metric had been met.

SEC source: 0000905148-24-003281 · form4.xml · derivative · entry 1

Schorno Dean L · CIK 0001509688 · EVP & Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,250

Underlying: Common Stock · 6,250 shares

Expires 2033-01-26

F1 · derivative.exercise_price: The Reporting Person was granted a stock option with a performance-based condition with respect to 6,250 shares of the Issuer's common stock on January 26, 2023, as adjusted for the one-for-ten reverse stock split effective June 27, 2024 (the "Reverse Stock Split"). The exercise price of this option is $18.70, which is the closing price of the Issuer's common stock on Nasdaq on the date of grant, as adjusted for the Reverse Stock Split. In light of the performance-based vesting condition, this grant was not reportable under Section 16 until the performance metric was satisfied. On November 25, 2024, it was determined that the performance metric had been met.

F1 · shares: The Reporting Person was granted a stock option with a performance-based condition with respect to 6,250 shares of the Issuer's common stock on January 26, 2023, as adjusted for the one-for-ten reverse stock split effective June 27, 2024 (the "Reverse Stock Split"). The exercise price of this option is $18.70, which is the closing price of the Issuer's common stock on Nasdaq on the date of grant, as adjusted for the Reverse Stock Split. In light of the performance-based vesting condition, this grant was not reportable under Section 16 until the performance metric was satisfied. On November 25, 2024, it was determined that the performance metric had been met.

F2 · derivative.exercise_date: The option was fully vested on November 25, 2024, the date the determination was made that the performance metric had been met.

F1 · derivative.underlying_shares: The Reporting Person was granted a stock option with a performance-based condition with respect to 6,250 shares of the Issuer's common stock on January 26, 2023, as adjusted for the one-for-ten reverse stock split effective June 27, 2024 (the "Reverse Stock Split"). The exercise price of this option is $18.70, which is the closing price of the Issuer's common stock on Nasdaq on the date of grant, as adjusted for the Reverse Stock Split. In light of the performance-based vesting condition, this grant was not reportable under Section 16 until the performance metric was satisfied. On November 25, 2024, it was determined that the performance metric had been met.

SEC source: 0000905148-24-002512 · form4.xml · derivative · entry 1

RODRIGUEZ RAUL R · CIK 0001190279 · Director · CEO, President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 32,500

Underlying: Common Stock · 32,500 shares

Expires 2030-02-06

F1 · derivative.exercise_price: The Reporting Person was granted a stock option with a performance-based condition with respect to 32,500 shares of the Issuer's common stock on February 6, 2020, as adjusted for the one-for-ten reverse stock split effective June 27, 2024 (the "Reverse Stock Split"). The exercise price of this option is $24.20, which is the closing price of the Issuer's common stock on Nasdaq on the date of grant, as adjusted for the Reverse Stock Split. In light of the performance-based vesting condition, this grant was not reportable under Section 16 until the performance metric was satisfied. On August 30, 2024, it was determined that the performance metric had been met.

F1 · shares: The Reporting Person was granted a stock option with a performance-based condition with respect to 32,500 shares of the Issuer's common stock on February 6, 2020, as adjusted for the one-for-ten reverse stock split effective June 27, 2024 (the "Reverse Stock Split"). The exercise price of this option is $24.20, which is the closing price of the Issuer's common stock on Nasdaq on the date of grant, as adjusted for the Reverse Stock Split. In light of the performance-based vesting condition, this grant was not reportable under Section 16 until the performance metric was satisfied. On August 30, 2024, it was determined that the performance metric had been met.

F2 · derivative.exercise_date: The option was fully vested on August 30, 2024, the date the determination was made that the performance metric had been met.

F1 · derivative.underlying_shares: The Reporting Person was granted a stock option with a performance-based condition with respect to 32,500 shares of the Issuer's common stock on February 6, 2020, as adjusted for the one-for-ten reverse stock split effective June 27, 2024 (the "Reverse Stock Split"). The exercise price of this option is $24.20, which is the closing price of the Issuer's common stock on Nasdaq on the date of grant, as adjusted for the Reverse Stock Split. In light of the performance-based vesting condition, this grant was not reportable under Section 16 until the performance metric was satisfied. On August 30, 2024, it was determined that the performance metric had been met.

SEC source: 0000905148-24-002511 · form4.xml · derivative · entry 1

Schorno Dean L · CIK 0001509688 · EVP & Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2030-02-06

F1 · derivative.exercise_price: The Reporting Person was granted a stock option with a performance-based condition with respect to 10,000 shares of the Issuer's common stock on February 6, 2020, as adjusted for the one-for-ten reverse stock split effective June 27, 2024 (the "Reverse Stock Split"). The exercise price of this option is $24.20, which is the closing price of the Issuer's common stock on Nasdaq on the date of grant, as adjusted for the Reverse Stock Split. In light of the performance-based vesting condition, this grant was not reportable under Section 16 until the performance metric was satisfied. On August 30, 2024, it was determined that the performance metric had been met.

F1 · shares: The Reporting Person was granted a stock option with a performance-based condition with respect to 10,000 shares of the Issuer's common stock on February 6, 2020, as adjusted for the one-for-ten reverse stock split effective June 27, 2024 (the "Reverse Stock Split"). The exercise price of this option is $24.20, which is the closing price of the Issuer's common stock on Nasdaq on the date of grant, as adjusted for the Reverse Stock Split. In light of the performance-based vesting condition, this grant was not reportable under Section 16 until the performance metric was satisfied. On August 30, 2024, it was determined that the performance metric had been met.

F2 · derivative.exercise_date: The option was fully vested on August 30, 2024, the date the determination was made that the performance metric had been met.

F1 · derivative.underlying_shares: The Reporting Person was granted a stock option with a performance-based condition with respect to 10,000 shares of the Issuer's common stock on February 6, 2020, as adjusted for the one-for-ten reverse stock split effective June 27, 2024 (the "Reverse Stock Split"). The exercise price of this option is $24.20, which is the closing price of the Issuer's common stock on Nasdaq on the date of grant, as adjusted for the Reverse Stock Split. In light of the performance-based vesting condition, this grant was not reportable under Section 16 until the performance metric was satisfied. On August 30, 2024, it was determined that the performance metric had been met.

SEC source: 0000905148-24-001656 · form4.xml · derivative · entry 2

Wasman Jane · CIK 0001352455 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2034-05-25

F2 · derivative.exercise_date: The shares vest monthly over one (1) year from the date of grant, subject to the Reporting Person's continuous service on the Company's Board of Directors.

SEC source: 0000905148-24-001656 · form4.xml · nonDerivative · entry 1

Wasman Jane · CIK 0001352455 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

F1 · shares: The shares of Common Stock are to be acquired upon the vesting of a Restricted Stock Unit award granted to the Reporting Person. The Restricted Stock Units shall fully vest on the date prior to the Company's next Annual Meeting, subject to the Reporting Person's continuous service on the Company's Board of Directors.

SEC source: 0000905148-24-001655 · form4.xml · derivative · entry 2

MOOS WALTER H · CIK 0001190272 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2034-05-25

F2 · derivative.exercise_date: The shares vest monthly over one (1) year from the date of grant, subject to the Reporting Person's continuous service on the Company's Board of Directors.

SEC source: 0000905148-24-001655 · form4.xml · nonDerivative · entry 1

MOOS WALTER H · CIK 0001190272 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 102,222

F1 · shares: The shares of Common Stock are to be acquired upon the vesting of a Restricted Stock Unit award granted to the Reporting Person. The Restricted Stock Units shall fully vest on the date prior to the Company's next Annual Meeting, subject to the Reporting Person's continuous service on the Company's Board of Directors.

SEC source: 0000905148-24-001654 · form4.xml · derivative · entry 2

LAPOINTE ANTHONY GREGG · CIK 0001331860 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2034-05-25

F2 · derivative.exercise_date: The shares vest monthly over one (1) year from the date of grant, subject to the Reporting Person's continuous service on the Company's Board of Directors.

SEC source: 0000905148-24-001654 · form4.xml · nonDerivative · entry 1

LAPOINTE ANTHONY GREGG · CIK 0001331860 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

F1 · shares: The shares of Common Stock are to be acquired upon the vesting of a Restricted Stock Unit award granted to the Reporting Person. The Restricted Stock Units shall fully vest on the date prior to the Company's next Annual Meeting, subject to the Reporting Person's continuous service on the Company's Board of Directors.

SEC source: 0000905148-24-001653 · form4.xml · derivative · entry 2

Kotzin Brian L. · CIK 0001715332 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2034-05-25

F2 · derivative.exercise_date: The shares vest monthly over one (1) year from the date of grant, subject to the Reporting Person's continuous service on the Company's Board of Directors.

SEC source: 0000905148-24-001653 · form4.xml · nonDerivative · entry 1

Kotzin Brian L. · CIK 0001715332 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

F1 · shares: The shares of Common Stock are to be acquired upon the vesting of a Restricted Stock Unit award granted to the Reporting Person. The Restricted Stock Units shall fully vest on the date prior to the Company's next Annual Meeting, subject to the Reporting Person's continuous service on the Company's Board of Directors.

SEC source: 0000905148-24-001652 · form4.xml · derivative · entry 2

HANNAH ALISON L. · CIK 0001645600 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2034-05-25

F2 · derivative.exercise_date: The shares vest monthly over one (1) year from the date of grant, subject to the Reporting Person's continuous service on the Company's Board of Directors.

SEC source: 0000905148-24-001652 · form4.xml · nonDerivative · entry 1

HANNAH ALISON L. · CIK 0001645600 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 81,250

F1 · shares: The shares of Common Stock are to be acquired upon the vesting of a Restricted Stock Unit award granted to the Reporting Person. The Restricted Stock Units shall fully vest on the date prior to the Company's next Annual Meeting, subject to the Reporting Person's continuous service on the Company's Board of Directors.

SEC source: 0000905148-24-001651 · form4.xml · derivative · entry 2

Ali-Jackson Kamil · CIK 0001654337 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2034-05-25

F2 · derivative.exercise_date: The shares vest monthly over one (1) year from the date of grant, subject to the Reporting Person's continuous service on the Company's Board of Directors.

SEC source: 0000905148-24-001651 · form4.xml · nonDerivative · entry 1

Ali-Jackson Kamil · CIK 0001654337 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 68,750

F1 · shares: The shares of Common Stock are to be acquired upon the vesting of a Restricted Stock Unit award granted to the Reporting Person. The Restricted Stock Units shall fully vest on the date prior to the Company's next Annual Meeting, subject to the Reporting Person's continuous service on the Company's Board of Directors.

SEC source: 0000905148-24-001016 · form4.xml · derivative · entry 1

Rojkjaer Lisa · CIK 0001846460 · EVP, Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 187,500

Underlying: Common Stock · 187,500 shares

Expires 2034-03-27

F1 · derivative.exercise_date: One-fourth (1/4th) of the shares subject to this option vest on March 11, 2025, and 1/48th of the shares subject to this option vest in substantially equal monthly installments over the thirty-six (36) months thereafter, subject to the Reporting Person's continuous service to the Issuer through each vesting date.

SEC source: 0000905148-24-000851 · form4.xml · derivative · entry 2

Schorno Dean L · CIK 0001509688 · EVP & Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 78,500

Underlying: Common Stock · 78,500 shares

Expires 2034-01-23

F2 · shares: The Reporting Person was granted an option with a performance-based condition with respect to 78,500 shares of the issuer's common stock on January 23, 2024. Thus, the exercise price of this option is $1.27 (the closing price of the issuer's common stock on Nasdaq the date of grant). In light of the performance-based vesting condition of this grant, the grant was not reportable under Section 16 until the performance metric was satisfied. On February 28, 2024, it was determined that the performance metric had been met.

F3 · derivative.exercise_date: The option was fully vested on February 28, 2024, the date the determination was made that the performance metric had been met.

SEC source: 0000905148-24-000851 · form4.xml · derivative · entry 1

Schorno Dean L · CIK 0001509688 · EVP & Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 62,500

Underlying: Common Stock · 62,500 shares

Expires 2033-01-26

F1 · shares: The Reporting Person was granted an option with a performance-based condition with respect to 62,500 shares of the issuer's common stock on January 26, 2023. Thus, the exercise price of this option is $1.87 (the closing price of the issuer's common stock on Nasdaq the date of grant). In light of the performance-based vesting condition of this grant, the grant was not reportable under Section 16 until the performance metric was satisfied. On February 28, 2024, it was determined that the performance metric had been met.

F3 · derivative.exercise_date: The option was fully vested on February 28, 2024, the date the determination was made that the performance metric had been met.

SEC source: 0000905148-24-000850 · form4.xml · derivative · entry 2

Santos David A · CIK 0001820066 · EVP, Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 78,500

Underlying: Common Stock · 78,500 shares

Expires 2034-01-23

F2 · shares: The Reporting Person was granted an option with a performance-based condition with respect to 78,500 shares of the issuer's common stock on January 23, 2024. Thus, the exercise price of this option is $1.27 (the closing price of the issuer's common stock on Nasdaq the date of grant). In light of the performance-based vesting condition of this grant, the grant was not reportable under Section 16 until the performance metric was satisfied. On February 28, 2024, it was determined that the performance metric had been met.

F3 · derivative.exercise_date: The option was fully vested on February 28, 2024, the date the determination was made that the performance metric had been met.

SEC source: 0000905148-24-000850 · form4.xml · derivative · entry 1

Santos David A · CIK 0001820066 · EVP, Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 80,000

Underlying: Common Stock · 80,000 shares

Expires 2033-01-26

F1 · shares: The Reporting Person was granted an option with a performance-based condition with respect to 80,000 shares of the issuer's common stock on January 26, 2023. Thus, the exercise price of this option is $1.87 (the closing price of the issuer's common stock on Nasdaq the date of grant). In light of the performance-based vesting condition of this grant, the grant was not reportable under Section 16 until the performance metric was satisfied. On February 28, 2024, it was determined that the performance metric had been met.

F3 · derivative.exercise_date: The option was fully vested on February 28, 2024, the date the determination was made that the performance metric had been met.

SEC source: 0000905148-24-000849 · form4.xml · derivative · entry 2

RODRIGUEZ RAUL R · CIK 0001190279 · Director · CEO, President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 300,000

Underlying: Common Stock · 300,000 shares

Expires 2034-01-23

F2 · shares: The Reporting Person was granted an option with a performance-based condition with respect to 300,000 shares of the issuer's common stock on January 23, 2024. Thus, the exercise price of this option is $1.27 (the closing price of the issuer's common stock on Nasdaq the date of grant). In light of the performance-based vesting condition of this grant, the grant was not reportable under Section 16 until the performance metric was satisfied. On February 28, 2024, it was determined that the performance metric had been met.

F3 · derivative.exercise_date: The option was fully vested on February 28, 2024, the date the determination was made that the performance metric had been met.

SEC source: 0000905148-24-000849 · form4.xml · derivative · entry 1

RODRIGUEZ RAUL R · CIK 0001190279 · Director · CEO, President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 300,000

Underlying: Common Stock · 300,000 shares

Expires 2033-01-26

F1 · shares: The Reporting Person was granted an option with a performance-based condition with respect to 300,000 shares of the issuer's common stock on January 26, 2023. Thus, the exercise price of this option is $1.87 (the closing price of the issuer's common stock on Nasdaq the date of grant). In light of the performance-based vesting condition of this grant, the grant was not reportable under Section 16 until the performance metric was satisfied. On February 28, 2024, it was determined that the performance metric had been met.

F3 · derivative.exercise_date: The option was fully vested on February 28, 2024, the date the determination was made that the performance metric had been met.

SEC source: 0000905148-24-000848 · form4.xml · derivative · entry 2

Furey Raymond J. · CIK 0001577899 · EVP, GC, CCO & Corp Sec

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 78,500

Underlying: Common Stock · 78,500 shares

Expires 2034-01-23

F2 · shares: The Reporting Person was granted an option with a performance-based condition with respect to 78,500 shares of the issuer's common stock on January 23, 2024. Thus, the exercise price of this option is $1.27 (the closing price of the issuer's common stock on Nasdaq the date of grant). In light of the performance-based vesting condition of this grant, the grant was not reportable under Section 16 until the performance metric was satisfied. On February 28, 2024, it was determined that the performance metric had been met.

F3 · derivative.exercise_date: The option was fully vested on February 28, 2024, the date the determination was made that the performance metric had been met.

SEC source: 0000905148-24-000848 · form4.xml · derivative · entry 1

Furey Raymond J. · CIK 0001577899 · EVP, GC, CCO & Corp Sec

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 93,750

Underlying: Common Stock · 93,750 shares

Expires 2032-12-08

F1 · shares: The Reporting Person was granted an option with a performance-based condition with respect to 93,750 shares of the issuer's common stock on December 8, 2022. Thus, the exercise price of this option is $0.8965 (the closing price of the issuer's common stock on Nasdaq the date of grant). In light of the performance-based vesting condition of this grant, the grant was not reportable under Section 16 until the performance metric was satisfied. On February 28, 2024, it was determined that the performance metric had been met.

F3 · derivative.exercise_date: The option was fully vested on February 28, 2024, the date the determination was made that the performance metric had been met.

SEC source: 0000905148-24-000447 · form4.xml · nonDerivative · entry 2

Santos David A · CIK 0001820066 · EVP, Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 349,093

F1 · kind: These shares were sold to cover tax withholding due upon vesting of Restricted Stock Units. Such "sales to cover" were automatically effected to satisfy tax withholding obligations and do not represent a discretionary trade by the Reporting Person.

SEC source: 0000905148-24-000446 · form4.xml · nonDerivative · entry 2

Schorno Dean L · CIK 0001509688 · EVP & Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 402,891

F1 · kind: These shares were sold to cover tax withholding due upon vesting of Restricted Stock Units. Such "sales to cover" were automatically effected to satisfy tax withholding obligations and do not represent a discretionary trade by the Reporting Person.

SEC source: 0000905148-24-000445 · form4.xml · nonDerivative · entry 2

RODRIGUEZ RAUL R · CIK 0001190279 · Director · CEO, President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,036,629

F1 · kind: These shares were sold to cover tax withholding due upon vesting of Restricted Stock Units. Such "sales to cover" were automatically effected to satisfy tax withholding obligations and do not represent a discretionary trade by the Reporting Person.

SEC source: 0000905148-24-000447 · form4.xml · nonDerivative · entry 1

Santos David A · CIK 0001820066 · EVP, Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 358,011

F1 · kind: These shares were sold to cover tax withholding due upon vesting of Restricted Stock Units. Such "sales to cover" were automatically effected to satisfy tax withholding obligations and do not represent a discretionary trade by the Reporting Person.

SEC source: 0000905148-24-000446 · form4.xml · nonDerivative · entry 1

Schorno Dean L · CIK 0001509688 · EVP & Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 409,918

F1 · kind: These shares were sold to cover tax withholding due upon vesting of Restricted Stock Units. Such "sales to cover" were automatically effected to satisfy tax withholding obligations and do not represent a discretionary trade by the Reporting Person.

F2 · price: The price reported in Column 4 is the weighted average price. These shares were sold in multiple transactions ranging from $1.1228 to $1.13. Upon request, the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission staff, full information regarding the shares sold at each such separate price.

SEC source: 0000905148-24-000445 · form4.xml · nonDerivative · entry 1

RODRIGUEZ RAUL R · CIK 0001190279 · Director · CEO, President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,067,174

F1 · kind: These shares were sold to cover tax withholding due upon vesting of Restricted Stock Units. Such "sales to cover" were automatically effected to satisfy tax withholding obligations and do not represent a discretionary trade by the Reporting Person.

F2 · price: The price reported in Column 4 is the weighted average price. These shares were sold in multiple transactions ranging from $1.13 to $1.135. Upon request, the Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the Securities and Exchange Commission staff, full information regarding the shares sold at each such separate price.