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Ultragenyx Pharmaceutical Inc.

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4337
SEC CIK
0001515673
Parsed reports
478

Last 12 months

Inside the activity.

0 purchase rows · 27 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 202500
Dec 202502
Jan 202601
Feb 202601
Mar 2026011
Apr 202601
May 202603
Jun 202603
Jul 202601
Aug 202602
Sep 202602
Oct 202600

Latest available

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
September 15, 2026 Filed Sep 15, 2026 22:57 UTC
Huizenga Theodore AlanSVP, Chief Accounting Officer
SaleCommon Stock 1,283 $13.57 $17,410.31
Disclosure

SEC source: 0001193125-26-392233 · ownership.xml · nonDerivative · entry 1

Huizenga Theodore Alan · CIK 0001603347 · SVP, Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 67,863

F1 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

Read SEC document
September 03, 2026 Filed Sep 8, 2026 16:29 UTC
Huizenga Theodore AlanSVP, Chief Accounting Officer
SaleCommon Stock 161 $13.99 $2,252.39
Disclosure

SEC source: 0001193125-26-384878 · ownership.xml · nonDerivative · entry 1

Huizenga Theodore Alan · CIK 0001603347 · SVP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 69,146

F1 · shares: Represents shares sold to pay required tax withholdings due to the vesting of RSUs.

F2 · balance_after: Includes 396 shares acquired under the Company's Amended and Restated Employee Stock Purchase Place on April 30, 2026.

F3 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

Read SEC document
August 03, 2026 Filed Aug 4, 2026 19:15 UTC
Parschauer Karah HerdmanEVP and Chief Legal Officer
SaleCommon Stock 1,900 $24.92 $47,348.00
Disclosure

SEC source: 0001193125-26-332547 · ownership.xml · nonDerivative · entry 1

Parschauer Karah Herdman · CIK 0001677455 · EVP and Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 92,562

F1 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

Read SEC document
August 03, 2026 Filed Aug 4, 2026 19:13 UTC
Horn HowardChief Financial Officer
SaleCommon Stock 4,696 $24.92 $117,024.32
Disclosure

SEC source: 0001193125-26-332536 · ownership.xml · nonDerivative · entry 1

Horn Howard · CIK 0001786335 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 96,295

F1 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

Read SEC document
July 01, 2026 Filed Jul 6, 2026 19:37 UTC
Horn HowardChief Financial Officer
SaleCommon Stock 4,698 $33.13 $155,644.74
Disclosure

SEC source: 0001193125-26-296128 · ownership.xml · nonDerivative · entry 1

Horn Howard · CIK 0001786335 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 100,991

F1 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

Read SEC document
June 15, 2026 Filed Jun 15, 2026 22:50 UTC SaleCommon Stock 2,000 $25.05 $50,100.00
Disclosure

SEC source: 0001796536-26-000007 · ownership.xml · nonDerivative · entry 1

Sanders Corazon (Corsee) D. · CIK 0001796536 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,095

F1 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

Read SEC document
June 15, 2026 Filed Jun 15, 2026 22:46 UTC
Parschauer Karah HerdmanEVP and Chief Legal Officer
SaleCommon Stock 1,899 $24.62 $46,753.38
Disclosure

SEC source: 0001677455-26-000002 · ownership.xml · nonDerivative · entry 1

Parschauer Karah Herdman · CIK 0001677455 · EVP and Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 94,462

F1 · balance_after: Includes 646 shares acquired under the Company's Amended and Restated Employee Stock Purchase Place on April 30, 2026

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

Read SEC document
June 01, 2026 Filed Jun 1, 2026 23:11 UTC
Horn HowardChief Financial Officer
SaleCommon Stock 4,653 $23.77 $110,601.81
Disclosure

SEC source: 0001786335-26-000002 · ownership.xml · nonDerivative · entry 1

Horn Howard · CIK 0001786335 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 105,689

F1 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

Read SEC document
May 18, 2026 Filed May 18, 2026 22:41 UTC SaleCommon Stock 5,740 $25.12 $144,188.80
Disclosure

SEC source: 0001713070-26-000002 · ownership.xml · nonDerivative · entry 2

SULIMAN SHEHNAAZ · CIK 0001713070 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 27,951

Read SEC document
May 14, 2026 Filed May 18, 2026 18:39 UTC
Ray AmritDirector
GrantStock Option (Right to Buy) · Derivative 14,058 $0.00 Strike: $25.80 $0.00
Disclosure

SEC source: 0001924797-26-000002 · ownership.xml · derivative · entry 2

Ray Amrit · CIK 0001924797 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,058

Underlying: Common Stock · 14,058 shares

Expires 2036-05-14

F2 · derivative.exercise_date: The option shall vest in full on the earlier of (i) the Company's next Annual Meeting of Stockholders or (ii) May 14, 2027.

Read SEC document
May 14, 2026 Filed May 18, 2026 18:39 UTC
Ray AmritDirector
GrantCommon Stock 7,751 $0.00 $0.00
Disclosure

SEC source: 0001924797-26-000002 · ownership.xml · nonDerivative · entry 1

Ray Amrit · CIK 0001924797 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,116

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2023 Incentive Plan. The RSUs shall vest in full on the earlier of (i) the Company's next Annual Meeting of Stockholders or (ii) May 14, 2027.

Read SEC document
May 14, 2026 Filed May 18, 2026 22:23 UTC GrantStock Option (Right to Buy) · Derivative 14,058 $0.00 Strike: $25.80 $0.00
Disclosure

SEC source: 0001193125-26-229224 · ownership.xml · derivative · entry 2

WELCH DANIEL G · CIK 0001206199 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,058

Underlying: Common Stock · 14,058 shares

Expires 2036-05-14

F2 · derivative.exercise_date: The option shall vest in full on the earlier of (i) the Company's next Annual Meeting of Stockholders or (ii) May 14, 2027.

Read SEC document
May 14, 2026 Filed May 18, 2026 22:23 UTC GrantCommon Stock 7,751 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-229224 · ownership.xml · nonDerivative · entry 1

WELCH DANIEL G · CIK 0001206199 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,441

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2023 Incentive Plan. The RSUs shall vest in full on the earlier of (i) the Company's next Annual Meeting of Stockholders or (ii) May 14, 2027.

Read SEC document
May 14, 2026 Filed May 18, 2026 22:21 UTC GrantStock Option (Right to Buy) · Derivative 14,058 $0.00 Strike: $25.80 $0.00
Disclosure

SEC source: 0001193125-26-229222 · ownership.xml · derivative · entry 2

Dunsire Deborah · CIK 0001332764 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,058

Underlying: Common Stock · 14,058 shares

Expires 2036-05-14

F2 · derivative.exercise_date: The option shall vest in full on the earlier of (i) the Company's next Annual Meeting of Stockholders or (ii) May 14, 2027.

Read SEC document
May 14, 2026 Filed May 18, 2026 22:21 UTC GrantCommon Stock 7,751 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-229222 · ownership.xml · nonDerivative · entry 1

Dunsire Deborah · CIK 0001332764 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 38,566

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2023 Incentive Plan. The RSUs shall vest in full on the earlier of (i) the Company's next Annual Meeting of Stockholders or (ii) May 14, 2027.

Read SEC document
May 14, 2026 Filed May 18, 2026 18:35 UTC GrantStock Option (Right to Buy) · Derivative 14,058 $0.00 Strike: $25.80 $0.00
Disclosure

SEC source: 0001380022-26-000002 · ownership.xml · derivative · entry 2

NARACHI MICHAEL · CIK 0001380022 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,058

Underlying: Common Stock · 14,058 shares

Expires 2036-05-14

F2 · derivative.exercise_date: The option shall vest in full on the earlier of (i) the Company's next Annual Meeting of Stockholders or (ii) May 14, 2027.

Read SEC document
May 14, 2026 Filed May 18, 2026 18:35 UTC GrantCommon Stock 7,751 $0.00 $0.00
Disclosure

SEC source: 0001380022-26-000002 · ownership.xml · nonDerivative · entry 1

NARACHI MICHAEL · CIK 0001380022 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,441

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2023 Incentive Plan. The RSUs shall vest in full on the earlier of (i) the Company's next Annual Meeting of Stockholders or (ii) May 14, 2027.

Read SEC document
May 14, 2026 Filed May 18, 2026 22:50 UTC GrantStock Option (Right to Buy) · Derivative 14,058 $0.00 Strike: $25.80 $0.00
Disclosure

SEC source: 0001397266-26-000002 · ownership.xml · derivative · entry 2

Fust Matthew K · CIK 0001397266 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,058

Underlying: Common Stock · 14,058 shares

Expires 2036-05-14

F2 · derivative.exercise_date: The option shall vest in full on the earlier of (i) the Company's next Annual Meeting of Stockholders or (ii) May 14, 2027.

Read SEC document
May 14, 2026 Filed May 18, 2026 22:50 UTC GrantCommon Stock 7,751 $0.00 $0.00
Disclosure

SEC source: 0001397266-26-000002 · ownership.xml · nonDerivative · entry 1

Fust Matthew K · CIK 0001397266 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,696

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2023 Incentive Plan. The RSUs shall vest in full on the earlier of (i) the Company's next Annual Meeting of Stockholders or (ii) May 14, 2027.

Read SEC document
May 14, 2026 Filed May 18, 2026 22:41 UTC GrantStock Option (Right to Buy) · Derivative 14,058 $0.00 Strike: $25.80 $0.00
Disclosure

SEC source: 0001713070-26-000002 · ownership.xml · derivative · entry 3

SULIMAN SHEHNAAZ · CIK 0001713070 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 14,058

Underlying: Common Stock · 14,058 shares

Expires 2036-05-14

F2 · derivative.exercise_date: The option shall vest in full on the earlier of (i) the Company's next Annual Meeting of Stockholders or (ii) May 14, 2027.

Read SEC document
May 14, 2026 Filed May 18, 2026 22:41 UTC GrantCommon Stock 7,751 $0.00 $0.00
Disclosure

SEC source: 0001713070-26-000002 · ownership.xml · nonDerivative · entry 1

SULIMAN SHEHNAAZ · CIK 0001713070 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 33,691

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2023 Incentive Plan. The RSUs shall vest in full on the earlier of (i) the Company's next Annual Meeting of Stockholders or (ii) May 14, 2027.

Read SEC document
May 14, 2026 Filed May 18, 2026 22:38 UTC GrantStock Option (Right to Buy) · Derivative 14,058 $0.00 Strike: $25.80 $0.00
Disclosure

SEC source: 0001796536-26-000004 · ownership.xml · derivative · entry 2

Sanders Corazon (Corsee) D. · CIK 0001796536 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,058

Underlying: Common Stock · 14,058 shares

Expires 2036-05-14

F2 · derivative.exercise_date: The option shall vest in full on the earlier of (i) the Company's next Annual Meeting of Stockholders or (ii) May 14, 2027.

Read SEC document
May 14, 2026 Filed May 18, 2026 22:38 UTC GrantCommon Stock 7,751 $0.00 $0.00
Disclosure

SEC source: 0001796536-26-000004 · ownership.xml · nonDerivative · entry 1

Sanders Corazon (Corsee) D. · CIK 0001796536 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,095

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2023 Incentive Plan. The RSUs shall vest in full on the earlier of (i) the Company's next Annual Meeting of Stockholders or (ii) May 14, 2027.

Read SEC document
May 05, 2026 Filed May 6, 2026 18:51 UTC
Crombez EricEVP and Chief Medical Officer
SaleCommon Stock 344 $24.96 $8,586.24
Disclosure

SEC source: 0001193125-26-208632 · ownership.xml · nonDerivative · entry 1

Crombez Eric · CIK 0001653052 · EVP and Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 111,189

F1 · shares: Represents shares sold to pay required tax withholdings due to the vesting of RSUs.

F2 · balance_after: Includes 558 shares acquired under the Company's Amended and Restated Employee Stock Purchase Plan on April 30, 2026

F3 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

Read SEC document
May 01, 2026 Filed May 4, 2026 21:35 UTC
Horn HowardChief Financial Officer
SaleCommon Stock 4,683 $24.90 $116,606.70
Disclosure

SEC source: 0001193125-26-204402 · ownership.xml · nonDerivative · entry 1

Horn Howard · CIK 0001786335 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 110,342

F1 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

Read SEC document
April 22, 2026 Filed Apr 24, 2026 20:39 UTC
Huizenga Theodore AlanSVP, Chief Accounting Officer
GrantStock Option (Right to Buy) · Derivative 7,348 $0.00 Strike: $24.61 $0.00
Disclosure

SEC source: 0001193125-26-177470 · ownership.xml · derivative · entry 2

Huizenga Theodore Alan · CIK 0001603347 · SVP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,348

Underlying: Common Stock · 7,348 shares

Expires 2036-04-22

F3 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

Read SEC document
April 22, 2026 Filed Apr 24, 2026 20:39 UTC
Huizenga Theodore AlanSVP, Chief Accounting Officer
GrantCommon Stock 20,241 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-177470 · ownership.xml · nonDerivative · entry 1

Huizenga Theodore Alan · CIK 0001603347 · SVP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 68,911

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2023 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

Read SEC document
April 16, 2026 Filed Apr 20, 2026 21:19 UTC
KAKKIS EMIL DDirector · President & CEO
GrantStock Option (Right to Buy) · Derivative 132,693 $0.00 Strike: $24.52 $0.00
Disclosure

SEC source: 0001193125-26-164308 · ownership.xml · derivative · entry 5

KAKKIS EMIL D · CIK 0001248093 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 132,693

Underlying: Common Stock · 132,693 shares

Expires 2036-04-16

F4 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

Read SEC document
April 16, 2026 Filed Apr 20, 2026 21:19 UTC
KAKKIS EMIL DDirector · President & CEO
GrantCommon Stock 76,745 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-164308 · ownership.xml · nonDerivative · entry 1

KAKKIS EMIL D · CIK 0001248093 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 735,739

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2023 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

Read SEC document
April 16, 2026 Filed Apr 20, 2026 21:17 UTC GrantStock Option (Right to Buy) · Derivative 79,936 $0.00 Strike: $24.52 $0.00
Disclosure

SEC source: 0001193125-26-164297 · ownership.xml · derivative · entry 2

Huang Dennis Karl · CIK 0001641217 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 79,936

Underlying: Common Stock · 79,936 shares

Expires 2036-04-16

F3 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

Read SEC document
April 16, 2026 Filed Apr 20, 2026 21:17 UTC GrantCommon Stock 23,116 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-164297 · ownership.xml · nonDerivative · entry 1

Huang Dennis Karl · CIK 0001641217 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 147,845

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2023 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

Read SEC document
April 16, 2026 Filed Apr 20, 2026 21:15 UTC
Parschauer Karah HerdmanEVP and Chief Legal Officer
GrantStock Option (Right to Buy) · Derivative 49,960 $0.00 Strike: $24.52 $0.00
Disclosure

SEC source: 0001193125-26-164281 · ownership.xml · derivative · entry 2

Parschauer Karah Herdman · CIK 0001677455 · EVP and Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,960

Underlying: Common Stock · 49,960 shares

Expires 2036-04-16

F3 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

Read SEC document
April 16, 2026 Filed Apr 20, 2026 21:15 UTC
Parschauer Karah HerdmanEVP and Chief Legal Officer
GrantCommon Stock 28,895 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-164281 · ownership.xml · nonDerivative · entry 1

Parschauer Karah Herdman · CIK 0001677455 · EVP and Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 95,715

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2023 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

Read SEC document
April 16, 2026 Filed Apr 20, 2026 21:16 UTC GrantStock Option (Right to Buy) · Derivative 79,936 $0.00 Strike: $24.52 $0.00
Disclosure

SEC source: 0001193125-26-164289 · ownership.xml · derivative · entry 2

Pinion John Richard · CIK 0001648096 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 79,936

Underlying: Common Stock · 79,936 shares

Expires 2036-04-16

F3 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

Read SEC document
April 16, 2026 Filed Apr 20, 2026 21:16 UTC GrantCommon Stock 23,116 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-164289 · ownership.xml · nonDerivative · entry 1

Pinion John Richard · CIK 0001648096 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 133,142

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2023 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

Read SEC document
April 16, 2026 Filed Apr 20, 2026 21:13 UTC
Harris ErikEVP & Chief Commercial Officer
GrantStock Option (Right to Buy) · Derivative 49,960 $0.00 Strike: $24.52 $0.00
Disclosure

SEC source: 0001193125-26-164267 · ownership.xml · derivative · entry 2

Harris Erik · CIK 0001780113 · EVP & Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,960

Underlying: Common Stock · 49,960 shares

Expires 2036-04-16

F3 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

Read SEC document
April 16, 2026 Filed Apr 20, 2026 21:13 UTC
Harris ErikEVP & Chief Commercial Officer
GrantCommon Stock 28,895 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-164267 · ownership.xml · nonDerivative · entry 1

Harris Erik · CIK 0001780113 · EVP & Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 118,410

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2023 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

Read SEC document
April 16, 2026 Filed Apr 20, 2026 21:09 UTC
Horn HowardChief Financial Officer
GrantStock Option (Right to Buy) · Derivative 59,952 $0.00 Strike: $24.52 $0.00
Disclosure

SEC source: 0001193125-26-164247 · ownership.xml · derivative · entry 2

Horn Howard · CIK 0001786335 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 59,952

Underlying: Common Stock · 59,952 shares

Expires 2036-04-16

F3 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

Read SEC document
April 16, 2026 Filed Apr 20, 2026 21:09 UTC
Horn HowardChief Financial Officer
GrantCommon Stock 34,674 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-164247 · ownership.xml · nonDerivative · entry 1

Horn Howard · CIK 0001786335 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 115,025

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2023 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

Read SEC document
April 16, 2026 Filed Apr 20, 2026 21:11 UTC
Crombez EricEVP and Chief Medical Officer
GrantStock Option (Right to Buy) · Derivative 59,952 $0.00 Strike: $24.52 $0.00
Disclosure

SEC source: 0001193125-26-164257 · ownership.xml · derivative · entry 2

Crombez Eric · CIK 0001653052 · EVP and Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 59,952

Underlying: Common Stock · 59,952 shares

Expires 2036-04-16

F3 · derivative.exercise_date: On the first anniversary of the grant date of the option (the "Option Anniversary Date"), 1/4th of the shares initially subject to the option shall vest; thereafter, 1/48th of the shares initially subject to the option shall vest on each month as measured from the Option Anniversary Date.

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April 16, 2026 Filed Apr 20, 2026 21:11 UTC
Crombez EricEVP and Chief Medical Officer
GrantCommon Stock 34,674 $0.00 $0.00
Disclosure

SEC source: 0001193125-26-164257 · ownership.xml · nonDerivative · entry 1

Crombez Eric · CIK 0001653052 · EVP and Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 110,975

F1 · shares: Award of Restricted Stock Units ("RSUs") under the Company's 2023 Incentive Plan. The RSUs shall vest with respect to 1/4th of the underlying shares on each anniversary of the grant date, such that the RSUs are fully vested on the fourth anniversary of the grant date

F2 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

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April 01, 2026 Filed Apr 2, 2026 22:19 UTC
Horn HowardChief Financial Officer
SaleCommon Stock 4,683 $20.97 $98,202.51
Disclosure

SEC source: 0001193125-26-140702 · ownership.xml · nonDerivative · entry 1

Horn Howard · CIK 0001786335 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 80,351

F1 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

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March 10, 2026 Filed Mar 10, 2026 20:51 UTC
Parschauer Karah HerdmanEVP and Chief Legal Officer
SaleCommon Stock 3,508 $22.67 $79,526.36
Disclosure

SEC source: 0001193125-26-100309 · ownership.xml · nonDerivative · entry 2

Parschauer Karah Herdman · CIK 0001677455 · EVP and Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 66,820

F1 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

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March 06, 2026 Filed Mar 10, 2026 20:51 UTC
Parschauer Karah HerdmanEVP and Chief Legal Officer
SaleCommon Stock 6,018 $21.40 $128,785.20
Disclosure

SEC source: 0001193125-26-100309 · ownership.xml · nonDerivative · entry 1

Parschauer Karah Herdman · CIK 0001677455 · EVP and Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 70,328

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March 03, 2026 Filed Mar 3, 2026 23:50 UTC
Horn HowardChief Financial Officer
SaleCommon Stock 1,635 $22.40 $36,624.00
Disclosure

SEC source: 0001193125-26-089107 · ownership.xml · nonDerivative · entry 4

Horn Howard · CIK 0001786335 · Chief Financial Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 85,034

F4 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

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March 02, 2026 Filed Mar 4, 2026 00:06 UTC
KAKKIS EMIL DDirector · President & CEO
SaleCommon Stock 54,404 $22.80 $1,240,411.20
Disclosure

SEC source: 0001193125-26-089278 · ownership.xml · nonDerivative · entry 2

KAKKIS EMIL D · CIK 0001248093 · Director · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 658,994

F2 · shares: Represents shares sold to pay required tax withholdings due to the vesting of RSUs.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $22.54 to $23.11 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range

F4 · balance_after: Includes 490 shares acquired under the Company's Amended and Restated Employee Stock Purchase Plan on April 30, 2025.

F5 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

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March 02, 2026 Filed Mar 4, 2026 00:08 UTC
Harris ErikEVP & Chief Commercial Officer
SaleCommon Stock 10,539 $22.80 $240,289.20
Disclosure

SEC source: 0001193125-26-089282 · ownership.xml · nonDerivative · entry 2

Harris Erik · CIK 0001780113 · EVP & Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 89,515

F2 · shares: Represents shares sold to pay required tax withholdings due to the vesting of RSUs.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $22.54 to $23.11 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range

F4 · balance_after: Includes a total of 556 shares acquired under the Company's Amended and Restated Employee Stock Purchase Plan on April 30, 2025 and October 31, 2025.

F5 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

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March 02, 2026 Filed Mar 4, 2026 00:09 UTC SaleCommon Stock 10,029 $22.80 $228,661.20
Disclosure

SEC source: 0001193125-26-089287 · ownership.xml · nonDerivative · entry 2

Pinion John Richard · CIK 0001648096 · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 110,026

F2 · shares: Represents shares sold to pay required tax withholdings due to the vesting of RSUs.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $22.54 to $23.11 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range

F4 · balance_after: Includes 490 shares acquired under the Company's Amended and Restated Employee Stock Purchase Plan on April 30, 2025

F5 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

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March 02, 2026 Filed Mar 3, 2026 23:51 UTC
Parschauer Karah HerdmanEVP and Chief Legal Officer
SaleCommon Stock 8,135 $22.80 $185,478.00
Disclosure

SEC source: 0001193125-26-089111 · ownership.xml · nonDerivative · entry 2

Parschauer Karah Herdman · CIK 0001677455 · EVP and Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 76,346

F2 · shares: Represents shares sold to pay required tax withholdings due to the vesting of RSUs.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $22.54 to $23.11 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range

F4 · balance_after: Includes 73 shares acquired under the Company's Amended and Restated Employee Stock Purchase Plan on October 31, 2025

F5 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

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March 02, 2026 Filed Mar 3, 2026 23:51 UTC
Huizenga Theodore AlanSVP, Chief Accounting Officer
SaleCommon Stock 1,632 $22.80 $37,209.60
Disclosure

SEC source: 0001193125-26-089109 · ownership.xml · nonDerivative · entry 2

Huizenga Theodore Alan · CIK 0001603347 · SVP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,670

F2 · shares: Represents shares sold to pay required tax withholdings due to the vesting of RSUs.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $22.54 to $23.11 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range

F4 · balance_after: Includes previously reported shares of common stock underlying RSUs granted to the Reporting Person, which are subject to certain vesting conditions.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.