PTGX

SEC source: 0001104659-24-003435 · tm243091-1_4seq1.xml · nonDerivative · entry 2

Gupta Suneel · CIK 0001763923 · Chief Development Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 187,567

F1 · kind: Sale of shares effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on April 25, 2023.

SEC source: 0001104659-24-003435 · tm243091-1_4seq1.xml · nonDerivative · entry 1

Gupta Suneel · CIK 0001763923 · Chief Development Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 192,567

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-24-001492 · tm241954-4_4seq1.xml · derivative · entry 2

PATEL DINESH V PH D · CIK 0001120477 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 315,250

Underlying: Common Stock · 315,250 shares

Expires 2034-01-02

F2 · derivative.exercise_date: The stock option vests in 48 equal monthly installments following January 2, 2024, subject to the Reporting Person's continued service to the Issuer through each applicable vesting date.

SEC source: 0001104659-24-001492 · tm241954-4_4seq1.xml · nonDerivative · entry 1

PATEL DINESH V PH D · CIK 0001120477 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 619,222

F1 · shares: Represents grant of restricted stock units payable solely in common stock that will vest in three equal annual installments on January 15, 2025, 2026 and 2027, subject to the Reporting Person's continued service to the Issuer through each applicable vesting date.

SEC source: 0001104659-24-001489 · tm241954-1_4seq1.xml · derivative · entry 2

Ali Asif · CIK 0001921163 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 78,000

Underlying: Common Stock · 78,000 shares

Expires 2034-01-02

F2 · derivative.exercise_date: The stock option vests in 48 equal monthly installments following January 2, 2024, subject to the Reporting Person's continued service to the Issuer through each applicable vesting date.

SEC source: 0001104659-24-001489 · tm241954-1_4seq1.xml · nonDerivative · entry 1

Ali Asif · CIK 0001921163 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 52,036

F1 · shares: Represents grant of restricted stock units payable solely in common stock that will vest in three equal annual installments on January 15, 2025, 2026 and 2027, subject to the Reporting Person's continued service to the Issuer through each applicable vesting date.

SEC source: 0001104659-24-001496 · tm241954-8_4seq1.xml · derivative · entry 1

O'Dowd Sarah A · CIK 0001447149 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,700

Underlying: Common Stock · 25,700 shares

Expires 2034-01-02

F1 · derivative.exercise_date: The stock option vests in 12 equal monthly installments following January 2, 2024, subject to the Reporting Person's continued service to the Issuer through each applicable vesting date.

SEC source: 0001104659-24-001497 · tm241954-9_4seq1.xml · derivative · entry 1

Waddill William D. · CIK 0001553338 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,700

Underlying: Common Stock · 25,700 shares

Expires 2034-01-02

F1 · derivative.exercise_date: The stock option vests in 12 equal monthly installments following January 2, 2024, subject to the Reporting Person's continued service to the Issuer through each applicable vesting date.

SEC source: 0001104659-24-001495 · tm241954-7_4seq1.xml · derivative · entry 2

Gupta Suneel · CIK 0001763923 · Chief Development Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 71,500

Underlying: Common Stock · 71,500 shares

Expires 2034-01-02

F2 · derivative.exercise_date: The stock option vests in 48 equal monthly installments following January 2, 2024, subject to the Reporting Person's continued service to the Issuer through each applicable vesting date.

SEC source: 0001104659-24-001495 · tm241954-7_4seq1.xml · nonDerivative · entry 1

Gupta Suneel · CIK 0001763923 · Chief Development Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 187,567

F1 · shares: Represents grant of restricted stock units payable solely in common stock that will vest in three equal annual installments on January 15, 2025, 2026 and 2027, subject to the Reporting Person's continued service to the Issuer through each applicable vesting date.

SEC source: 0001104659-24-001494 · tm241954-6_4seq1.xml · derivative · entry 1

Williams Lewis T · CIK 0001475714 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,700

Underlying: Common Stock · 25,700 shares

Expires 2034-01-02

F1 · derivative.exercise_date: The stock option vests in 12 equal monthly installments following January 2, 2024, subject to the Reporting Person's continued service to the Issuer through each applicable vesting date.

SEC source: 0001104659-24-001493 · tm241954-5_4seq1.xml · derivative · entry 1

SELICK HAROLD E · CIK 0001287233 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,700

Underlying: Common Stock · 25,700 shares

Expires 2034-01-02

F1 · derivative.exercise_date: The stock option vests in 12 equal monthly installments following January 2, 2024, subject to the Reporting Person's continued service to the Issuer through each applicable vesting date.

SEC source: 0001104659-24-001491 · tm241954-3_4seq1.xml · derivative · entry 1

Giraudo Bryan · CIK 0001740847 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,700

Underlying: Common Stock · 25,700 shares

Expires 2034-01-02

F1 · derivative.exercise_date: The stock option vests in 12 equal monthly installments following January 2, 2024, subject to the Reporting Person's continued service to the Issuer through each applicable vesting date.

SEC source: 0001104659-24-001490 · tm241954-2_4seq1.xml · derivative · entry 3

MOLINA ARTURO MD · CIK 0001398940 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 97,500

Underlying: Common Stock · 97,500 shares

Expires 2034-01-02

F3 · derivative.exercise_date: The stock option vests in 48 equal monthly installments following January 2, 2024, subject to the Reporting Person's continued service to the Issuer through each applicable vesting date.

SEC source: 0001104659-24-001490 · tm241954-2_4seq1.xml · nonDerivative · entry 2

MOLINA ARTURO MD · CIK 0001398940 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,777

F2 · shares: Represents grant of restricted stock units payable solely in common stock that will vest in three equal annual installments on January 15, 2025, 2026 and 2027, subject to the Reporting Person's continued service to the Issuer through each applicable vesting date.

SEC source: 0001104659-23-126419 · tm2333032-1_4seq1.xml · nonDerivative · entry 1

PATEL DINESH V PH D · CIK 0001120477 · Director · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 534,347

F1 · kind: Sale of shares effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 20, 2023.

F2 · price: The price reported represents the weighted average sale price per share. The shares were sold in multiple transactions at prices ranging from $20.00 to $20.20. Upon request by the staff of the U.S. Securities and Exchange Commission, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price.

SEC source: 0001104659-24-001490 · tm241954-2_4seq1.xml · nonDerivative · entry 1

MOLINA ARTURO MD · CIK 0001398940 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,527

F1 · shares: Sale of shares to cover tax withholding obligation incurred upon settlement of restricted stock units.

SEC source: 0001104659-23-112599 · tm2328975-3_4seq1.xml · derivative · entry 1

Swisher Daniel N JR · CIK 0001323113 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Common Stock · 45,000 shares

Expires 2033-10-26

F1 · derivative.exercise_date: The options vest in 36 equal monthly installments following October 26, 2023, subject to the Reporting Person's continued service to the Issuer through each applicable vesting date.

SEC source: 0001104659-23-110803 · tm2328975-1_4seq1.xml · derivative · entry 2

Gupta Suneel · CIK 0001763923 · Chief Development Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 20,000 shares

Expires 2029-01-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: These stock options are fully vested.

SEC source: 0001104659-23-110803 · tm2328975-1_4seq1.xml · nonDerivative · entry 1

Gupta Suneel · CIK 0001763923 · Chief Development Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 168,317

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes an aggregate of 280 shares acquired by the Reporting Person under the Issuer's 2016 Employee Stock Purchase Plan on September 9, 2023.

SEC source: 0001104659-23-110157 · tm2328807-1_4seq1.xml · derivative · entry 2

PATEL DINESH V PH D · CIK 0001120477 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 54,000

Underlying: Common Stock · 6,000 shares

Expires 2026-04-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: These stock options are fully vested.

SEC source: 0001104659-23-110157 · tm2328807-1_4seq1.xml · nonDerivative · entry 1

PATEL DINESH V PH D · CIK 0001120477 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 609,347

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes an aggregate of 401 shares acquired by the Reporting Person under the Issuer's 2016 Employee Stock Purchase Plan on September 9, 2023.

SEC source: 0001104659-23-067690 · tm2317724-2_4seq1.xml · nonDerivative · entry 3

PATEL DINESH V PH D · CIK 0001120477 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 602,946

F4 · shares: Represents shares withheld by the Issuer to satisfy tax withholding obligations in connection with the settlement of PSUs.

F1 · balance_after: The shares of common stock reported on this Form 4 are subject to a lock-up agreement between the reporting person and J.P. Morgan Securities LLC, Jefferies LLC and Piper Sandler & Co., dated April 4, 2023 (the "Lock-up Date") pursuant to which the shares of common stock reported herein cannot be sold for 60 days following the Lock-up Date.

SEC source: 0001104659-23-067690 · tm2317724-2_4seq1.xml · nonDerivative · entry 2

PATEL DINESH V PH D · CIK 0001120477 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 615,111

F2 · shares: Represents settlement by the Issuer of performance stock units ("PSUs") granted to the Reporting Person under the Company's 2016 Equity Incentive Plan on May 31, 2022, which vested based on the Issuer's achievement of corporate performance objectives.

F1 · balance_after: The shares of common stock reported on this Form 4 are subject to a lock-up agreement between the reporting person and J.P. Morgan Securities LLC, Jefferies LLC and Piper Sandler & Co., dated April 4, 2023 (the "Lock-up Date") pursuant to which the shares of common stock reported herein cannot be sold for 60 days following the Lock-up Date.

F3 · balance_after: Includes an aggregate of 1,663 shares acquired by the Reporting Person under the Issuer's 2016 Employee Stock Purchase Plan on March 9, 2023.

SEC source: 0001104659-23-067689 · tm2317724-1_4seq1.xml · nonDerivative · entry 2

Ali Asif · CIK 0001921163 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,036

F3 · shares: Represents shares withheld by the Issuer to satisfy tax withholding obligations in connection with the settlement of PSUs.

F2 · balance_after: The shares of common stock reported on this Form 4 are subject to a lock-up agreement between the reporting person and J.P. Morgan Securities LLC, Jefferies LLC and Piper Sandler & Co., dated April 4, 2023 (the "Lock-up Date") pursuant to which the shares of common stock reported herein cannot be sold for 60 days following the Lock-up Date.

SEC source: 0001104659-23-067689 · tm2317724-1_4seq1.xml · nonDerivative · entry 1

Ali Asif · CIK 0001921163 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,186

F1 · shares: Represents settlement by the Issuer of performance stock units ("PSUs") granted to the Reporting Person under the Company's 2016 Equity Incentive Plan on May 31, 2022, which vested based on the Issuer's achievement of corporate performance objectives.

F2 · balance_after: The shares of common stock reported on this Form 4 are subject to a lock-up agreement between the reporting person and J.P. Morgan Securities LLC, Jefferies LLC and Piper Sandler & Co., dated April 4, 2023 (the "Lock-up Date") pursuant to which the shares of common stock reported herein cannot be sold for 60 days following the Lock-up Date.

SEC source: 0001104659-23-067691 · tm2317724-3_4seq1.xml · nonDerivative · entry 2

Gupta Suneel · CIK 0001763923 · Chief Development Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 148,037

F4 · shares: Represents shares withheld by the Issuer to satisfy tax withholding obligations in connection with the settlement of PSUs.

F2 · balance_after: The shares of common stock reported on this Form 4 are subject to a lock-up agreement between the reporting person and J.P. Morgan Securities LLC, Jefferies LLC and Piper Sandler & Co., dated April 4, 2023 (the "Lock-up Date") pursuant to which the shares of common stock reported herein cannot be sold for 60 days following the Lock-up Date.

SEC source: 0001104659-23-067691 · tm2317724-3_4seq1.xml · nonDerivative · entry 1

Gupta Suneel · CIK 0001763923 · Chief Development Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 152,187

F1 · shares: Represents settlement by the Issuer of performance stock units ("PSUs") granted to the Reporting Person under the Company's 2016 Equity Incentive Plan on May 31, 2022, which vested based on the Issuer's achievement of corporate performance objectives.

F2 · balance_after: The shares of common stock reported on this Form 4 are subject to a lock-up agreement between the reporting person and J.P. Morgan Securities LLC, Jefferies LLC and Piper Sandler & Co., dated April 4, 2023 (the "Lock-up Date") pursuant to which the shares of common stock reported herein cannot be sold for 60 days following the Lock-up Date.

F3 · balance_after: Includes an aggregate of 2,000 shares acquired by the Reporting Person under the Issuer's 2016 Employee Stock Purchase Plan on March 9, 2023.

SEC source: 0001104659-23-047208 · tm2312473-2_4seq1.xml · nonDerivative · entry 1

Ali Asif · CIK 0001921163 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,186

F1 · shares: Represents shares withheld by the Issuer to satisfy tax withholding obligations in connection with the release of 3,437 vested restricted stock units on April 18, 2023.

F2 · balance_after: The shares of common stock reported on this Form 4 are subject to a lock-up agreement between the reporting person and J.P. Morgan Securities LLC, Jefferies LLC and Piper Sandler & Co., dated April 4, 2023 (the "Lock-up Date") pursuant to which the shares of common stock reported herein cannot be sold for 60 days following the Lock-up Date.

SEC source: 0001104659-23-044168 · tm2312473-1_4seq.xml · derivative · entry 2

SELICK HAROLD E · CIK 0001287233 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 6,196 shares

Expires 2023-09-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The stock option is vested in full.

SEC source: 0001104659-23-044168 · tm2312473-1_4seq.xml · nonDerivative · entry 1

SELICK HAROLD E · CIK 0001287233 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,506

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: The shares of common stock reported on this Form 4 are subject to a lock-up agreement between the reporting person and J.P. Morgan Securities LLC, Jefferies LLC and Piper Sandler & Co., dated April 4, 2023 (the "Lock-up Date") pursuant to which the shares of common stock reported herein cannot be sold for 60 days following the Lock-up Date.

SEC source: 0001104659-23-067690 · tm2317724-2_4seq1.xml · nonDerivative · entry 1

PATEL DINESH V PH D · CIK 0001120477 · Director · President and CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 583,448

F1 · balance_after: The shares of common stock reported on this Form 4 are subject to a lock-up agreement between the reporting person and J.P. Morgan Securities LLC, Jefferies LLC and Piper Sandler & Co., dated April 4, 2023 (the "Lock-up Date") pursuant to which the shares of common stock reported herein cannot be sold for 60 days following the Lock-up Date.

SEC source: 0001104659-23-004721 · tm233829-7_4.xml · derivative · entry 3

PATEL DINESH V PH D · CIK 0001120477 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 600,000

Underlying: Common Stock · 600,000 shares

Expires 2033-01-15

F2 · derivative.exercise_date: The stock option vests in 48 equal monthly installments following the date of grant.

SEC source: 0001104659-23-004725 · tm233829-3_4seq1.xml · derivative · entry 2

Ali Asif · CIK 0001921163 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 63,750

Underlying: Common Stock · 63,750 shares

Expires 2033-01-15

F2 · derivative.exercise_date: The stock option vests in 48 equal monthly installments following the date of grant.

SEC source: 0001104659-23-004725 · tm233829-3_4seq1.xml · nonDerivative · entry 1

Ali Asif · CIK 0001921163 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,375

F1 · shares: Represents grant of restricted stock units payable solely in common stock that will vest in three annual installments on January 15, 2024, 2025 and 2026.

SEC source: 0001104659-23-004734 · tm233829-1_4seq1.xml · derivative · entry 1

Noonberg Sarah B. · CIK 0001706301 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2033-01-15

F1 · derivative.exercise_date: The stock option vests in 12 equal monthly installments following the date of grant.

SEC source: 0001104659-23-004732 · tm233829-2_4seq1.xml · derivative · entry 1

O'Dowd Sarah A · CIK 0001447149 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2033-01-15

F1 · derivative.exercise_date: The stock option vests in 12 equal monthly installments following the date of grant.

SEC source: 0001104659-23-004737 · tm233829-9_4seq1.xml · derivative · entry 1

Williams Lewis T · CIK 0001475714 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2033-01-15

F1 · derivative.exercise_date: The stock option vests in 12 equal monthly installments following the date of grant.

SEC source: 0001104659-23-004731 · tm233829-10_4seq1.xml · derivative · entry 1

SELICK HAROLD E · CIK 0001287233 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2033-01-15

F1 · derivative.exercise_date: The stock option vests in 12 equal monthly installments following the date of grant.

SEC source: 0001104659-23-004735 · tm233829-4_4seq1.xml · derivative · entry 1

Waddill William D. · CIK 0001553338 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2033-01-15

F1 · derivative.exercise_date: The stock option vests in 12 equal monthly installments following the date of grant.

SEC source: 0001104659-23-004739 · tm233829-6_4seq1.xml · derivative · entry 1

Giraudo Bryan · CIK 0001740847 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2033-01-15

F1 · derivative.exercise_date: The stock option vests in 12 equal monthly installments following the date of grant.

SEC source: 0001104659-23-004730 · tm233829-8_4seq1.xml · derivative · entry 2

Gupta Suneel · CIK 0001763923 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 123,750

Underlying: Common Stock · 123,750 shares

Expires 2033-01-15

F3 · derivative.exercise_date: The stock option vests in 48 equal monthly installments following the date of grant.

SEC source: 0001104659-23-004730 · tm233829-8_4seq1.xml · nonDerivative · entry 1

Gupta Suneel · CIK 0001763923 · Chief Development Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 138,187

F1 · shares: Represents grant of restricted stock units payable solely in common stock that will vest in three annual installments on January 15, 2024, 2025 and 2026.

F2 · balance_after: Includes 1 share acquired by the Reporting Person under the Issuer's 2016 Employee Stock Purchase Plan on September 9, 2022.

SEC source: 0001104659-23-004722 · tm233829-5_4seq1.xml · derivative · entry 2

MOLINA ARTURO MD · CIK 0001398940 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,750

Underlying: Common Stock · 18,750 shares

Expires 2033-01-15

F2 · derivative.exercise_date: The stock option vests in 48 equal monthly installments following the date of grant.

SEC source: 0001104659-23-004722 · tm233829-5_4seq1.xml · nonDerivative · entry 1

MOLINA ARTURO MD · CIK 0001398940 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,375

F1 · shares: Represents grant of restricted stock units payable solely in common stock that will vest in three annual installments on January 15, 2024, 2025 and 2026.

SEC source: 0001104659-23-004721 · tm233829-7_4.xml · nonDerivative · entry 2

PATEL DINESH V PH D · CIK 0001120477 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 598,096

F1 · balance_after: Includes an aggregate of 164 shares acquired by the Reporting Person under the Issuer's 2016 Employee Stock Purchase Plan on September 9, 2022.

SEC source: 0001104659-22-119974 · tm2230775-3_4seq1.xml · derivative · entry 10

Liu David Y · CIK 0001675881 · Chief R&D Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 35,331 shares

Expires 2026-04-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The stock option is vested in full.

SEC source: 0001104659-22-119974 · tm2230775-3_4seq1.xml · derivative · entry 9

Liu David Y · CIK 0001675881 · Chief R&D Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 35,656 shares

Expires 2025-10-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The stock option is vested in full.

SEC source: 0001104659-22-119974 · tm2230775-3_4seq1.xml · derivative · entry 8

Liu David Y · CIK 0001675881 · Chief R&D Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 5,999 shares

Expires 2025-03-26

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The stock option is vested in full.

SEC source: 0001104659-22-119974 · tm2230775-3_4seq1.xml · derivative · entry 7

Liu David Y · CIK 0001675881 · Chief R&D Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 9,726 shares

Expires 2024-10-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The stock option is vested in full.