PRTA

SEC source: 0001140361-23-028869 · form4.xml · nonDerivative · entry 1

Karp Carol D. · CIK 0001692214 · Chief Regulatory Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-23-027617 · form4.xml · derivative · entry 5

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 110,000

Underlying: Ordinary Shares · 5,000 shares

Expires 2029-07-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on July 1, 2020, and vest and become exercisable with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001140361-23-027617 · form4.xml · nonDerivative · entry 4

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 20, 2022.

F4 · price: The transaction was executed in multiple trades in prices ranging from $65.75 to $66.255, inclusive.

SEC source: 0001140361-23-027617 · form4.xml · nonDerivative · entry 3

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 711

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 20, 2022.

F3 · price: The transaction was executed in multiple trades in prices ranging from $64.73 to $65.72, inclusive.

SEC source: 0001140361-23-027617 · form4.xml · nonDerivative · entry 2

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,789

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 20, 2022.

F2 · price: The transaction was executed in multiple trades in prices ranging from $63.705 to $64.62, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the ranges set forth in footnotes 2 through 4 of this Form 4.

SEC source: 0001140361-23-027617 · form4.xml · nonDerivative · entry 1

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-23-025833 · form4.xml · derivative · entry 4

Walker Karin L · CIK 0001559422 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 20,481

Underlying: Ordinary Shares · 5,000 shares

Expires 2028-06-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on June 21, 2019, and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001140361-23-025833 · form4.xml · nonDerivative · entry 3

Walker Karin L · CIK 0001559422 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 22, 2022.

F3 · price: The transaction was executed in multiple trades in prices ranging from $74.175 to $74.98, inclusive.

SEC source: 0001140361-23-025833 · form4.xml · nonDerivative · entry 2

Walker Karin L · CIK 0001559422 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,177

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 22, 2022.

F2 · price: The transaction was executed in multiple trades in prices ranging from $73.09 to $74.06, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the ranges set forth in footnotes 2 through 3 of this Form 4.

SEC source: 0001140361-23-025833 · form4.xml · nonDerivative · entry 1

Walker Karin L · CIK 0001559422 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-23-025342 · form4.xml · derivative · entry 9

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 50,000 shares

Expires 2025-03-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: All shares subject to the option have fully vested.

F7 · balance_after: The Reporting Person holds options that give him the right to acquire an aggregate of 806,837 shares at exercise prices ranging from $12.15 to $52.97, of which 638,253 are currently exercisable, and 168,584 are currently unexercisable but vest over time, subject to the Reporting Person's continued employment with the Issuer on each applicable vesting date of each option award. Certain of these options are subject to the Court Order.

SEC source: 0001140361-23-025342 · form4.xml · derivative · entry 8

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 45,000 shares

Expires 2024-02-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: All shares subject to the option have fully vested.

F7 · balance_after: The Reporting Person holds options that give him the right to acquire an aggregate of 806,837 shares at exercise prices ranging from $12.15 to $52.97, of which 638,253 are currently exercisable, and 168,584 are currently unexercisable but vest over time, subject to the Reporting Person's continued employment with the Issuer on each applicable vesting date of each option award. Certain of these options are subject to the Court Order.

SEC source: 0001140361-23-025342 · form4.xml · nonDerivative · entry 7

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,200

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 10, 2023 in connection with a court stipulation and order regarding the separation of assets ("Court Order") in accordance with a divorce settlement agreement.

SEC source: 0001140361-23-025342 · form4.xml · nonDerivative · entry 6

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,300

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 10, 2023 in connection with a court stipulation and order regarding the separation of assets ("Court Order") in accordance with a divorce settlement agreement.

F5 · price: The transaction was executed in multiple trades in prices ranging from $75.04 to $76.025, inclusive.

SEC source: 0001140361-23-025342 · form4.xml · nonDerivative · entry 5

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,515

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 10, 2023 in connection with a court stipulation and order regarding the separation of assets ("Court Order") in accordance with a divorce settlement agreement.

F4 · price: The transaction was executed in multiple trades in prices ranging from $74.03 to $75.02, inclusive.

SEC source: 0001140361-23-025342 · form4.xml · nonDerivative · entry 4

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 49,559

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 10, 2023 in connection with a court stipulation and order regarding the separation of assets ("Court Order") in accordance with a divorce settlement agreement.

F3 · price: The transaction was executed in multiple trades in prices ranging from $73.03 to $74.025, inclusive.

SEC source: 0001140361-23-025342 · form4.xml · nonDerivative · entry 3

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 84,199

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 10, 2023 in connection with a court stipulation and order regarding the separation of assets ("Court Order") in accordance with a divorce settlement agreement.

F2 · price: The transaction was executed in multiple trades in prices ranging from $72.03 to $73.02, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the ranges set forth in footnotes 2 through 5 of this Form 4.

SEC source: 0001140361-23-025342 · form4.xml · nonDerivative · entry 2

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 98,200

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-23-025342 · form4.xml · nonDerivative · entry 1

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 48,200

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-23-025344 · form4.xml · derivative · entry 5

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 45,000 shares

Expires 2024-02-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: All shares subject to the option have fully vested.

F6 · balance_after: The Reporting Person holds options that give him the right to acquire an aggregate of 2,114,700 shares at exercise prices ranging from $12.15 to $52.97, of which 1,626,365 are currently exercisable, and 488,335 are currently unexercisable but vest over time, subject to the Reporting Person's continued employment with the Issuer on each applicable vesting date of each option award.

SEC source: 0001140361-23-025344 · form4.xml · nonDerivative · entry 4

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,793

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 6, 2023.

F4 · price: The transaction was executed in multiple trades in prices ranging from $74.06 to $74.99, inclusive.

SEC source: 0001140361-23-025344 · form4.xml · nonDerivative · entry 3

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 27,727

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 6, 2023.

F3 · price: The transaction was executed in multiple trades in prices ranging from $73.06 to $74.05, inclusive.

SEC source: 0001140361-23-025344 · form4.xml · nonDerivative · entry 2

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 47,591

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on January 6, 2023.

F2 · price: The transaction was executed in multiple trades in prices ranging from $72.06 to $73.055, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the ranges set forth in footnotes 2 through 4 of this Form 4.

SEC source: 0001140361-23-025344 · form4.xml · nonDerivative · entry 1

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 57,793

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-23-025830 · form4.xml · derivative · entry 1

COLLIER RICHARD T · CIK 0001110751 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Ordinary Shares · 15,000 shares

Expires 2033-05-17

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of the first anniversary of the grant date or the day of the annual general meeting in 2024 of the Issuer's shareholders, assuming continuous service as a director until such vesting date.

SEC source: 0001140361-23-025826 · form4.xml · derivative · entry 1

Kim Helen Susan · CIK 0001422772 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Ordinary Shares · 15,000 shares

Expires 2033-05-17

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of the first anniversary of the grant date or the day of the annual general meeting in 2024 of the Issuer's shareholders, assuming continuous service as a director until such vesting date.

SEC source: 0001140361-23-025828 · form4.xml · derivative · entry 1

Ekman Lars · CIK 0001376117 · Director · Chair of the Board

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Ordinary Shares · 15,000 shares

Expires 2033-05-17

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of the first anniversary of the grant date or the day of the annual general meeting in 2024 of the Issuer's shareholders, assuming continuous service as a director until such vesting date.

SEC source: 0001140361-23-025832 · form4.xml · derivative · entry 1

Cooke Shane · CIK 0001524823 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Ordinary Shares · 15,000 shares

Expires 2033-05-17

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of the first anniversary of the grant date or the day of the annual general meeting in 2024 of the Issuer's shareholders, assuming continuous service as a director until such vesting date.

SEC source: 0001140361-23-025831 · form4.xml · derivative · entry 1

Cobb Paula K · CIK 0001763372 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Ordinary Shares · 15,000 shares

Expires 2033-05-17

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of the first anniversary of the grant date or the day of the annual general meeting in 2024 of the Issuer's shareholders, assuming continuous service as a director until such vesting date.

SEC source: 0001140361-23-025829 · form4.xml · derivative · entry 1

Dunn William H. Jr. · CIK 0001977655 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Ordinary Shares · 30,000 shares

Expires 2033-05-17

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 33 and 1/3% of the total number of shares subject to the option on the first anniversary of the grant date, 33 and 1/3% on the second anniversary of the grant date, and the remaining 33 and 1/3% on the earlier of the third anniversary of the grant date or the day of the annual general meeting in 2026 of the Issuer's shareholders, assuming continuous services as a director until each such vesting date.

SEC source: 0001140361-23-025825 · form4.xml · derivative · entry 1

Selkoe Dennis J. · CIK 0001582306 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Ordinary Shares · 15,000 shares

Expires 2033-05-17

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of the first anniversary of the grant date or the day of the annual general meeting in 2024 of the Issuer's shareholders, assuming continuous service as a director until such vesting date.

SEC source: 0001140361-23-025827 · form4.xml · derivative · entry 1

Harfstrand Karl Anders Olof · CIK 0001646451 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Ordinary Shares · 15,000 shares

Expires 2033-05-17

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of the first anniversary of the grant date or the day of the annual general meeting in 2024 of the Issuer's shareholders, assuming continuous service as a director until such vesting date.

SEC source: 0001140361-23-023303 · form4.xml · derivative · entry 6

Selkoe Dennis J. · CIK 0001582306 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,000

Underlying: Ordinary Shares · 9,000 shares

Expires 2031-05-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: All shares subject to the option have fully vested.

SEC source: 0001140361-23-023303 · form4.xml · derivative · entry 5

Selkoe Dennis J. · CIK 0001582306 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 6,000 shares

Expires 2029-05-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: All shares subject to the option have fully vested.

SEC source: 0001140361-23-023303 · form4.xml · nonDerivative · entry 3

Selkoe Dennis J. · CIK 0001582306 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,845

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 22, 2022.

SEC source: 0001140361-23-023303 · form4.xml · nonDerivative · entry 2

Selkoe Dennis J. · CIK 0001582306 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 17,845

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-23-023303 · form4.xml · nonDerivative · entry 1

Selkoe Dennis J. · CIK 0001582306 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,845

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-23-021747 · form4.xml · derivative · entry 4

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 115,000

Underlying: Ordinary Shares · 5,000 shares

Expires 2029-07-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on July 1, 2020, and vest and become exercisable with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001140361-23-021747 · form4.xml · nonDerivative · entry 3

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 20, 2022.

F3 · price: The transaction was executed in multiple trades in prices ranging from $54.01 to $54.38, inclusive.

SEC source: 0001140361-23-021747 · form4.xml · nonDerivative · entry 2

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 320

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 20, 2022.

F2 · price: The transaction was executed in multiple trades in prices ranging from $52.865 to $53.69, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the ranges set forth in footnotes 2 through 3 of this Form 4.

SEC source: 0001140361-23-021747 · form4.xml · nonDerivative · entry 1

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-23-019684 · form4.xml · derivative · entry 4

Walker Karin L · CIK 0001559422 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,481

Underlying: Ordinary Shares · 5,000 shares

Expires 2028-06-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on June 21, 2019, and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001140361-23-019684 · form4.xml · nonDerivative · entry 3

Walker Karin L · CIK 0001559422 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 22, 2022.

F3 · price: The transaction was executed in multiple trades in prices ranging from $53.165 to $53.35, inclusive.

SEC source: 0001140361-23-019684 · form4.xml · nonDerivative · entry 2

Walker Karin L · CIK 0001559422 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,083

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 22, 2022.

F2 · price: The transaction was executed in multiple trades in prices ranging from $52.14 to $53.06, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the ranges set forth in footnotes 2 through 3 of this Form 4.

SEC source: 0001140361-23-019684 · form4.xml · nonDerivative · entry 1

Walker Karin L · CIK 0001559422 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-23-015527 · form4.xml · derivative · entry 4

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 120,000

Underlying: Ordinary Shares · 5,000 shares

Expires 2029-07-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on July 1, 2020, and vest and become exercisable with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001140361-23-015527 · form4.xml · nonDerivative · entry 3

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 20, 2022.

F3 · price: The transaction was executed in multiple trades in prices ranging from $49.05 to $49.505, inclusive.

SEC source: 0001140361-23-015527 · form4.xml · nonDerivative · entry 2

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,266

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on September 20, 2022.

F2 · price: The transaction was executed in multiple trades in prices ranging from $48.02 to $49.00, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the ranges set forth in footnotes 2 through 3 of this Form 4.

SEC source: 0001140361-23-015527 · form4.xml · nonDerivative · entry 1

Malecek Michael J · CIK 0001779336 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-23-013190 · form4.xml · derivative · entry 4

Walker Karin L · CIK 0001559422 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,481

Underlying: Ordinary Shares · 5,000 shares

Expires 2028-06-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The shares subject to the option vested and became exercisable as to 25% of the total number of shares subject to the option on June 21, 2019, and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

F5 · balance_after: The Reporting Person's prior Form 4 filed on March 17, 2023 inadvertently transposed the first two digits of the number of options reported in Column 9, reporting 53,481 options beneficially owned following the Reporting Person's transaction in these options on March 15, 2023, instead of the correct number of 35,481 options beneficially owned. The correct number of 35,481 options beneficially owned was used for purposes of calculating the number of options reported in Column 9 of this Form 4.