PRTA

SEC source: 0001567619-22-015086 · doc1.xml · nonDerivative · entry 3

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,299

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-22-015086 · doc1.xml · derivative · entry 6

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 77,744

Underlying: Ordinary Shares · 20,954 shares

Expires 2023-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The option was granted on January 29, 2013 and all shares subject to the option were fully vested and exercisable. The option will expire in approximately six months and be forfeited to the extent it is not exercised on or prior to January 29, 2023.

SEC source: 0001567619-22-015086 · doc1.xml · nonDerivative · entry 2

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,793

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: The transaction was executed in multiple trades in prices ranging from $32.00 to $32.465, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001567619-22-015086 · doc1.xml · nonDerivative · entry 1

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 33,747

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-22-014909 · doc1.xml · derivative · entry 3

Garren Hideki · CIK 0001854126 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 238,000

Underlying: Ordinary Shares · 4,000 shares

Expires 2031-04-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 25% of the total number of shares subject to the option on April 5, 2022 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001567619-22-014909 · doc1.xml · nonDerivative · entry 2

Garren Hideki · CIK 0001854126 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001567619-22-014909 · doc1.xml · nonDerivative · entry 1

Garren Hideki · CIK 0001854126 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-22-027528 · form4.xml · derivative · entry 3

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 98,698

Underlying: Ordinary Shares · 376 shares

Expires 2023-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option was granted on January 29, 2013 and all shares subject to the option were fully vested and exercisable. The option will expire in approximately six months and be forfeited to the extent it is not exercised on or prior to January 29, 2023.

F3 · balance_after: The Reporting Person holds options that give him the right to acquire an aggregate of 2,103,398 shares at exercises prices ranging from $6.41 to $32.45, of which 1,571,938 are currently exercisable, and 531,460 are currently unexercisable but vest over time, subject to the Reporting Person's continued employment with the Issuer on each applicable vesting date of each option award.

SEC source: 0001140361-22-027528 · form4.xml · nonDerivative · entry 2

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,793

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001140361-22-027528 · form4.xml · nonDerivative · entry 1

Kinney Gene G. · CIK 0001564380 · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,169

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-22-014382 · doc1.xml · derivative · entry 11

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,000

Underlying: Ordinary Shares · 7,320 shares

Expires 2023-03-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The option was granted on April 1, 2013 and all shares subject to the option were fully vested and exercisable. The option will expire in approximately eight months and be forfeited to the extent it is not exercised on or prior to March 31, 2023.

F7 · balance_after: The Reporting Person holds options that give him the right to acquire an aggregate of 933,837 shares at exercises prices ranging from $6.73 to $32.45, of which 733,253 are currently exercisable, and 200,584 are currently unexercisable but vest over time, subject to the Reporting Person's continued employment with the Issuer on each applicable vesting date of each option award. Certain of these options are subject to the Court Order.

SEC source: 0001567619-22-014382 · doc1.xml · nonDerivative · entry 8

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,200

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in connection with a court stipulation and proposed order regarding the separation of assets ("Court Order") in anticipation of a potential divorce settlement agreement.

F5 · price: The transaction was executed in multiple trades in prices ranging from $32.15 to $32.91, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001567619-22-014382 · doc1.xml · nonDerivative · entry 7

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,520

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-22-014382 · doc1.xml · derivative · entry 10

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 87,320

Underlying: Ordinary Shares · 20,560 shares

Expires 2023-03-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The option was granted on April 1, 2013 and all shares subject to the option were fully vested and exercisable. The option will expire in approximately eight months and be forfeited to the extent it is not exercised on or prior to March 31, 2023.

SEC source: 0001567619-22-014382 · doc1.xml · nonDerivative · entry 6

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,200

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in connection with a court stipulation and proposed order regarding the separation of assets ("Court Order") in anticipation of a potential divorce settlement agreement.

SEC source: 0001567619-22-014382 · doc1.xml · nonDerivative · entry 5

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,205

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in connection with a court stipulation and proposed order regarding the separation of assets ("Court Order") in anticipation of a potential divorce settlement agreement.

F4 · price: The transaction was executed in multiple trades in prices ranging from $32.28 to $32.895, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001567619-22-014382 · doc1.xml · nonDerivative · entry 4

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,760

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-22-014382 · doc1.xml · derivative · entry 9

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 107,880

Underlying: Ordinary Shares · 42,120 shares

Expires 2023-03-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The option was granted on April 1, 2013 and all shares subject to the option were fully vested and exercisable. The option will expire in approximately eight months and be forfeited to the extent it is not exercised on or prior to March 31, 2023.

SEC source: 0001567619-22-014382 · doc1.xml · nonDerivative · entry 3

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,200

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in connection with a court stipulation and proposed order regarding the separation of assets ("Court Order") in anticipation of a potential divorce settlement agreement.

F3 · price: The transaction was executed in multiple trades in prices ranging from $32.54 to $33.12, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001567619-22-014382 · doc1.xml · nonDerivative · entry 2

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,184

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person in connection with a court stipulation and proposed order regarding the separation of assets ("Court Order") in anticipation of a potential divorce settlement agreement.

F2 · price: The transaction was executed in multiple trades in prices ranging from $31.54 to $32.535, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001567619-22-014382 · doc1.xml · nonDerivative · entry 1

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,320

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-22-014381 · doc1.xml · derivative · entry 3

Cooke Shane · CIK 0001524823 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Ordinary Shares · 15,000 shares

Expires 2023-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option was granted on January 29, 2013, and all shares subject to the option were fully vested and exercisable January 29, 2014. The option will expire in approximately six months and be forfeited to the extent it is not exercised on or prior to January 29, 2023.

F2 · derivative.expiration_date: The option was granted on January 29, 2013, and all shares subject to the option were fully vested and exercisable January 29, 2014. The option will expire in approximately six months and be forfeited to the extent it is not exercised on or prior to January 29, 2023.

SEC source: 0001567619-22-014381 · doc1.xml · nonDerivative · entry 2

Cooke Shane · CIK 0001524823 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001567619-22-014381 · doc1.xml · nonDerivative · entry 1

Cooke Shane · CIK 0001524823 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-22-013840 · doc1.xml · derivative · entry 3

Garren Hideki · CIK 0001854126 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 242,000

Underlying: Ordinary Shares · 8,000 shares

Expires 2031-04-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 25% of the total number of shares subject to the option on April 5, 2022 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001567619-22-013840 · doc1.xml · nonDerivative · entry 2

Garren Hideki · CIK 0001854126 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

SEC source: 0001567619-22-013840 · doc1.xml · nonDerivative · entry 1

Garren Hideki · CIK 0001854126 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-22-021109 · form4.xml · derivative · entry 1

Patel Sanjiv · CIK 0001816210 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Ordinary Shares · 15,000 shares

Expires 2032-05-18

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of the first anniversary of the grant date or the day of the annual general meeting in 2023 of the Issuer's shareholders, assuming continuous service as a director until such vesting date.

SEC source: 0001140361-22-021106 · form4.xml · derivative · entry 1

COLLIER RICHARD T · CIK 0001110751 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Ordinary Shares · 15,000 shares

Expires 2032-05-18

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of the first anniversary of the grant date or the day of the annual general meeting in 2023 of the Issuer's shareholders, assuming continuous service as a director until such vesting date.

SEC source: 0001140361-22-021103 · form4.xml · derivative · entry 1

Ekman Lars · CIK 0001376117 · Director · Chair of the Board

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Ordinary Shares · 15,000 shares

Expires 2032-05-18

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of the first anniversary of the grant date or the day of the annual general meeting in 2023 of the Issuer's shareholders, assuming continuous service as a director until such vesting date.

SEC source: 0001140361-22-021107 · form4.xml · derivative · entry 1

Cooke Shane · CIK 0001524823 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Ordinary Shares · 15,000 shares

Expires 2032-05-18

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of the first anniversary of the grant date or the day of the annual general meeting in 2023 of the Issuer's shareholders, assuming continuous service as a director until such vesting date.

SEC source: 0001140361-22-021108 · form4.xml · derivative · entry 1

Cobb Paula K · CIK 0001763372 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Ordinary Shares · 15,000 shares

Expires 2032-05-18

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of the first anniversary of the grant date or the day of the annual general meeting in 2023 of the Issuer's shareholders, assuming continuous service as a director until such vesting date.

SEC source: 0001140361-22-021105 · form4.xml · derivative · entry 1

Harfstrand Karl Anders Olof · CIK 0001646451 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Ordinary Shares · 15,000 shares

Expires 2032-05-18

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of the first anniversary of the grant date or the day of the annual general meeting in 2023 of the Issuer's shareholders, assuming continuous service as a director until such vesting date.

SEC source: 0001140361-22-021104 · form4.xml · derivative · entry 1

Selkoe Dennis J. · CIK 0001582306 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Ordinary Shares · 15,000 shares

Expires 2032-05-18

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of the first anniversary of the grant date or the day of the annual general meeting in 2023 of the Issuer's shareholders, assuming continuous service as a director until such vesting date.

SEC source: 0001567619-22-009730 · doc1.xml · nonDerivative · entry 2

EcoR1 Capital, LLC · CIK 0001587114 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Note

Disclosed balance after: 11,584,280

F1 · kind: EcoR1 Capital Fund, L.P. ("Capital Fund") and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund") are private investment funds managed by EcoR1 Capital, LLC ("EcoR1") on a parri passu basis. These securities were transferred from Capital Fund to Qualified Fund as part of a periodic rebalancing of the portfolios of the funds.

F2 · ownership.nature: The filing persons (the "Filers") are EcoR1, Oleg Nodelman and Qualified Fund. EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund and Capital Fund (collectively, the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to beneficially own the securities indirectly as the investment adviser to the Funds, and Mr. Nodelman may be deemed to beneficially own them indirectly as the control person of EcoR1. The Filers disclaim beneficial ownership of such securities except to the extent of their pecuniary interest therein.

SEC source: 0001567619-22-009730 · doc1.xml · nonDerivative · entry 1

EcoR1 Capital, LLC · CIK 0001587114 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Notes

Disclosed balance after: 11,584,280

F1 · kind: EcoR1 Capital Fund, L.P. ("Capital Fund") and EcoR1 Capital Fund Qualified, L.P. ("Qualified Fund") are private investment funds managed by EcoR1 Capital, LLC ("EcoR1") on a parri passu basis. These securities were transferred from Capital Fund to Qualified Fund as part of a periodic rebalancing of the portfolios of the funds.

F2 · ownership.nature: The filing persons (the "Filers") are EcoR1, Oleg Nodelman and Qualified Fund. EcoR1 is the general partner and investment adviser of private funds, including Qualified Fund and Capital Fund (collectively, the "Funds"). Mr. Nodelman is the manager and controlling owner of EcoR1. EcoR1 is filing this Form 4 for itself, Mr. Nodelman and Qualified Fund. The Filers are filing this Form 4 jointly, but not as a group, and each expressly disclaims membership in a group, within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. The Funds hold these securities directly for the benefit of their investors. EcoR1 may be deemed to beneficially own the securities indirectly as the investment adviser to the Funds, and Mr. Nodelman may be deemed to beneficially own them indirectly as the control person of EcoR1. The Filers disclaim beneficial ownership of such securities except to the extent of their pecuniary interest therein.

F3 · ownership.nature: After this transaction, Qualified Fund held 10,847,852 of the Issuer's Ordinary Shares.

SEC source: 0001567619-22-008508 · doc1.xml · derivative · entry 5

Cooke Shane · CIK 0001524823 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Ordinary Shares · 5,000 shares

Expires 2023-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option was granted on January 29, 2013, and all shares subject to the option were fully vested and exercisable January 29, 2014. The option will expire in approximately 10 months and be forfeited to the extent it is not exercised on or prior to January 29, 2023.

F2 · derivative.expiration_date: The option was granted on January 29, 2013, and all shares subject to the option were fully vested and exercisable January 29, 2014. The option will expire in approximately 10 months and be forfeited to the extent it is not exercised on or prior to January 29, 2023.

SEC source: 0001567619-22-008508 · doc1.xml · nonDerivative · entry 4

Cooke Shane · CIK 0001524823 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F5 · price: The transaction was executed in multiple trades in prices ranging from $36.40 to $36.83, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001567619-22-008508 · doc1.xml · nonDerivative · entry 3

Cooke Shane · CIK 0001524823 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 514

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: The transaction was executed in multiple trades in prices ranging from $35.40 to $36.34, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001567619-22-008508 · doc1.xml · nonDerivative · entry 2

Cooke Shane · CIK 0001524823 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,998

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The transaction was executed in multiple trades in prices ranging from $34.21 to $35.09, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001567619-22-008508 · doc1.xml · nonDerivative · entry 1

Cooke Shane · CIK 0001524823 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-22-008265 · doc1.xml · derivative · entry 4

COLLIER RICHARD T · CIK 0001110751 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Ordinary Shares · 5,000 shares

Expires 2023-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option was granted on January 29, 2013, and all shares subject to the option were fully vested and exercisable January 29, 2014. The option will expire in approximately 10 months and be forfeited to the extent it is not exercised on or prior to January 29, 2023.

F2 · derivative.expiration_date: The option was granted on January 29, 2013, and all shares subject to the option were fully vested and exercisable January 29, 2014. The option will expire in approximately 10 months and be forfeited to the extent it is not exercised on or prior to January 29, 2023.

SEC source: 0001567619-22-008265 · doc1.xml · nonDerivative · entry 3

COLLIER RICHARD T · CIK 0001110751 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,219

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: The transaction was executed in multiple trades in prices ranging from $39.51 to $40.03, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001567619-22-008265 · doc1.xml · nonDerivative · entry 2

COLLIER RICHARD T · CIK 0001110751 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,588

F1 · kind: The transactions reported in the Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: The transaction was executed in multiple trades in prices ranging from $38.485 to $39.47, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001567619-22-008265 · doc1.xml · nonDerivative · entry 1

COLLIER RICHARD T · CIK 0001110751 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,219

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001140361-22-006895 · form4.xml · derivative · entry 1

Garren Hideki · CIK 0001854126 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 85,000

Underlying: Ordinary Shares · 85,000 shares

Expires 2032-02-23

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 25% of the total number of shares subject to the option on February 23, 2023 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001140361-22-006889 · form4.xml · derivative · entry 1

Smith Brandon S. · CIK 0001805226 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 85,000

Underlying: Ordinary Shares · 85,000 shares

Expires 2032-02-23

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 25% of the total number of shares subject to the option on February 23, 2023 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001140361-22-006897 · form4.xml · derivative · entry 1

Zago Wagner M. · CIK 0001708681 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 85,000

Underlying: Ordinary Shares · 85,000 shares

Expires 2032-02-23

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 25% of the total number of shares subject to the option on February 23, 2023 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001140361-22-006899 · form4.xml · derivative · entry 1

Karp Carol D. · CIK 0001692214 · Chief Regulatory Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 85,000

Underlying: Ordinary Shares · 85,000 shares

Expires 2032-02-23

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 25% of the total number of shares subject to the option on February 23, 2023 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.

SEC source: 0001140361-22-006891 · form4.xml · derivative · entry 1

Nguyen Tran · CIK 0001457013 · Chief Strategy Officer and CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 85,000

Underlying: Ordinary Shares · 85,000 shares

Expires 2032-02-23

F1 · derivative.exercise_date: The shares subject to the option will vest and become exercisable as to 25% of the total number of shares subject to the option on February 23, 2023 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued employment with the Issuer on each such vesting date.