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Nasdaq · USD

PRAX

Praxis Precision Medicines, Inc.

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Tapewire entity
3538
SEC CIK
0001689548
Parsed reports
206

Last 12 months

Inside the activity.

0 purchase rows · 18 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 202506
Dec 202500
Jan 202600
Feb 202600
Mar 202600
Apr 202600
May 202600
Jun 2026012
Jul 202600
Aug 202600
Sep 202600
Oct 202600

Latest available

Insider transactions

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
July 08, 2026 Filed Jul 8, 2026 20:56 UTC
Souza MarcioDirector · Chief Executive Officer
GiftCommon Stock 2,600 $0.00 $0.00
Disclosure

SEC source: 0001707657-26-000008 · wk-form4_1783544160.xml · nonDerivative · entry 2

Souza Marcio · CIK 0001707657 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Indirect · Held by spouse

Disclosed balance after: 0

F1 · kind: This transaction represents a bona fide gift of common stock to the Souza 2026 Trust.

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July 08, 2026 Filed Jul 8, 2026 20:56 UTC
Souza MarcioDirector · Chief Executive Officer
GiftCommon Stock 20,521 $0.00 $0.00
Disclosure

SEC source: 0001707657-26-000008 · wk-form4_1783544160.xml · nonDerivative · entry 1

Souza Marcio · CIK 0001707657 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 56,495

F1 · kind: This transaction represents a bona fide gift of common stock to the Souza 2026 Trust.

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June 24, 2026 Filed Jun 26, 2026 21:09 UTC Exercise / conversionStock Option (Right to Buy) · Derivative 3,034 $0.00 Strike: $147.30 $0.00
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · derivative · entry 16

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,034 shares

Expires 2032-05-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F14 · derivative.exercise_date: This option was fully vested as of May 23, 2025.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC Exercise / conversionStock Option (Right to Buy) · Derivative 8,566 $0.00 Strike: $44.25 $0.00
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · derivative · entry 15

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 8,566 shares

Expires 2034-06-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F13 · derivative.exercise_date: This option was fully vested as of June 5, 2025.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC SaleCommon Stock 837 $315.71 $264,245.09
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 14

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,337

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F12 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $315.590 to $316.010. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC SaleCommon Stock 1,279 $314.90 $402,758.38
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 13

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,174

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F11 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $314.400 to $315.380. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

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June 24, 2026 Filed Jun 26, 2026 21:09 UTC SaleCommon Stock 504 $313.66 $158,086.15
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 12

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,453

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F10 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $313.400 to $314.000. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC SaleCommon Stock 1,004 $312.83 $314,081.32
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 11

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,957

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F9 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $312.370 to $313.280. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC SaleCommon Stock 2,854 $311.91 $890,202.56
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 10

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,961

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F8 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $311.340 to $312.320. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC SaleCommon Stock 1,750 $310.89 $544,055.75
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 9

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,815

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F7 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $310.340 to $311.300. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC SaleCommon Stock 999 $309.38 $309,073.62
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 8

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10,565

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F6 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $308.900 to $309.790. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC SaleCommon Stock 1,240 $308.24 $382,221.32
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 7

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 11,564

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F5 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $307.900 to $308.870. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC SaleCommon Stock 683 $306.77 $209,521.86
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 6

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,804

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F4 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $306.365 to $307.180. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC SaleCommon Stock 320 $305.31 $97,699.20
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 5

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 13,487

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F3 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $305.000 to $305.830. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC SaleCommon Stock 120 $303.13 $36,375.24
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 4

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 13,807

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F2 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $302.500 to $303.440. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC SaleCommon Stock 10 $301.44 $3,014.40
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 3

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 13,927

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC Exercise / conversionCommon Stock 3,034 $147.30 $446,908.20
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 2

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 13,937

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC Exercise / conversionCommon Stock 8,566 $44.25 $379,045.50
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 1

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10,903

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
June 10, 2026 Filed Jun 12, 2026 21:23 UTC GrantStock Option (Right to Buy) · Derivative 648 $0.00 Strike: $240.66 $0.00
Disclosure

SEC source: 0001689548-26-000058 · wk-form4_1781299429.xml · derivative · entry 2

KINDLER JEFFREY B · CIK 0001174454 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 648

Underlying: Common Stock · 648 shares

Expires 2036-06-10

F2 · derivative.exercise_date: The shares subject to this option shall vest in twelve (12) equal monthly installments occurring on the 10th day of each month, with the first such installment occurring on July 10, 2026 and the final such installment occurring on the earlier of (i) June 10, 2027 or (ii) the date of the Issuer's 2027 annual meeting of stockholders.

Read SEC document
June 10, 2026 Filed Jun 12, 2026 21:23 UTC GrantCommon Stock 1,371 $0.00 $0.00
Disclosure

SEC source: 0001689548-26-000058 · wk-form4_1781299429.xml · nonDerivative · entry 1

KINDLER JEFFREY B · CIK 0001174454 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,537

F1 · kind: Mr. Kindler was awarded 1,371 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. The restricted stock units vest in a single annual installment on the earlier of (i) June 10, 2027 or (ii) the date of the Issuer's 2027 annual meeting of stockholders. The restricted stock units may be settled only by delivering shares of the Issuer's common stock, and thus, the grant is being reported in Table 1 as allowed per SEC guidance.

Read SEC document
June 10, 2026 Filed Jun 12, 2026 21:24 UTC GrantStock Option (Right to Buy) · Derivative 648 $0.00 Strike: $240.66 $0.00
Disclosure

SEC source: 0001689548-26-000064 · wk-form4_1781299464.xml · derivative · entry 2

Arbuckle Stuart A · CIK 0001557290 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 648

Underlying: Common Stock · 648 shares

Expires 2036-06-10

F2 · derivative.exercise_date: The shares subject to this option shall vest in twelve (12) equal monthly installments occurring on the 10th day of each month, with the first such installment occurring on July 10, 2026 and the final such installment occurring on the earlier of (i) June 10, 2027 or (ii) the date of the Issuer's 2027 annual meeting of stockholders.

Read SEC document
June 10, 2026 Filed Jun 12, 2026 21:24 UTC GrantCommon Stock 1,371 $0.00 $0.00
Disclosure

SEC source: 0001689548-26-000064 · wk-form4_1781299464.xml · nonDerivative · entry 1

Arbuckle Stuart A · CIK 0001557290 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,537

F1 · kind: Mr. Arbuckle was awarded 1,371 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. The restricted stock units vest in a single annual installment on the earlier of (i) June 10, 2027 or (ii) the date of the Issuer's 2027 annual meeting of stockholders. The restricted stock units may be settled only by delivering shares of the Issuer's common stock, and thus, the grant is being reported in Table 1 as allowed per SEC guidance.

Read SEC document
June 10, 2026 Filed Jun 12, 2026 21:24 UTC GrantStock Option (Right to Buy) · Derivative 648 $0.00 Strike: $240.66 $0.00
Disclosure

SEC source: 0001689548-26-000063 · wk-form4_1781299458.xml · derivative · entry 2

Chodakewitz Jeffrey · CIK 0001610876 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 648

Underlying: Common Stock · 648 shares

Expires 2036-06-10

F2 · derivative.exercise_date: The shares subject to this option shall vest in twelve (12) equal monthly installments occurring on the 10th day of each month, with the first such installment occurring on July 10, 2026 and the final such installment occurring on the earlier of (i) June 10, 2027 or (ii) the date of the Issuer's 2027 annual meeting of stockholders.

Read SEC document
June 10, 2026 Filed Jun 12, 2026 21:24 UTC GrantCommon Stock 1,371 $0.00 $0.00
Disclosure

SEC source: 0001689548-26-000063 · wk-form4_1781299458.xml · nonDerivative · entry 1

Chodakewitz Jeffrey · CIK 0001610876 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,371

F1 · kind: Dr. Chodakewitz was awarded 1,371 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. The restricted stock units vest in a single annual installment on the earlier of (i) June 10, 2027 or (ii) the date of the Issuer's 2027 annual meeting of stockholders. The restricted stock units may be settled only by delivering shares of the Issuer's common stock, and thus, the grant is being reported in Table 1 as allowed per SEC guidance.

Read SEC document
June 10, 2026 Filed Jun 12, 2026 21:24 UTC GrantStock Option (Right to Buy) · Derivative 648 $0.00 Strike: $240.66 $0.00
Disclosure

SEC source: 0001689548-26-000062 · wk-form4_1781299452.xml · derivative · entry 2

YOUNG WILLIAM D · CIK 0001217420 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 648

Underlying: Common Stock · 648 shares

Expires 2036-06-10

F2 · derivative.exercise_date: The shares subject to this option shall vest in twelve (12) equal monthly installments occurring on the 10th day of each month, with the first such installment occurring on July 10, 2026 and the final such installment occurring on the earlier of (i) June 10, 2027 or (ii) the date of the Issuer's 2027 annual meeting of stockholders.

Read SEC document
June 10, 2026 Filed Jun 12, 2026 21:24 UTC GrantCommon Stock 1,371 $0.00 $0.00
Disclosure

SEC source: 0001689548-26-000062 · wk-form4_1781299452.xml · nonDerivative · entry 1

YOUNG WILLIAM D · CIK 0001217420 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,269

F1 · kind: Mr. Young was awarded 1,371 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. The restricted stock units vest in a single annual installment on the earlier of (i) June 10, 2027 or (ii) the date of the Issuer's 2027 annual meeting of stockholders. The restricted stock units may be settled only by delivering shares of the Issuer's common stock, and thus, the grant is being reported in Table 1 as allowed per SEC guidance.

Read SEC document
June 10, 2026 Filed Jun 12, 2026 21:24 UTC GrantStock Option (Right to Buy) · Derivative 648 $0.00 Strike: $240.66 $0.00
Disclosure

SEC source: 0001689548-26-000061 · wk-form4_1781299446.xml · derivative · entry 2

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 648

Underlying: Common Stock · 648 shares

Expires 2036-06-10

F2 · derivative.exercise_date: The shares subject to this option shall vest in twelve (12) equal monthly installments occurring on the 10th day of each month, with the first such installment occurring on July 10, 2026 and the final such installment occurring on the earlier of (i) June 10, 2027 or (ii) the date of the Issuer's 2027 annual meeting of stockholders.

Read SEC document
June 10, 2026 Filed Jun 12, 2026 21:24 UTC GrantCommon Stock 1,371 $0.00 $0.00
Disclosure

SEC source: 0001689548-26-000061 · wk-form4_1781299446.xml · nonDerivative · entry 1

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,337

F1 · kind: Ms. DeSimone was awarded 1,371 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. The restricted stock units vest in a single annual installment on the earlier of (i) June 10, 2027 or (ii) the date of the Issuer's 2027 annual meeting of stockholders. The restricted stock units may be settled only by delivering shares of the Issuer's common stock, and thus, the grant is being reported in Table 1 as allowed per SEC guidance.

Read SEC document
June 10, 2026 Filed Jun 12, 2026 21:24 UTC GrantStock Option (Right to Buy) · Derivative 648 $0.00 Strike: $240.66 $0.00
Disclosure

SEC source: 0001689548-26-000060 · wk-form4_1781299441.xml · derivative · entry 2

Cudkowicz Merit Ester · CIK 0001856299 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 648

Underlying: Common Stock · 648 shares

Expires 2036-06-10

F2 · derivative.exercise_date: The shares subject to this option shall vest in twelve (12) equal monthly installments occurring on the 10th day of each month, with the first such installment occurring on July 10, 2026 and the final such installment occurring on the earlier of (i) June 10, 2027 or (ii) the date of the Issuer's 2027 annual meeting of stockholders.

Read SEC document
June 10, 2026 Filed Jun 12, 2026 21:24 UTC GrantCommon Stock 1,371 $0.00 $0.00
Disclosure

SEC source: 0001689548-26-000060 · wk-form4_1781299441.xml · nonDerivative · entry 1

Cudkowicz Merit Ester · CIK 0001856299 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,371

F1 · kind: Dr. Cudkowicz was awarded 1,371 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. The restricted stock units vest in a single annual installment on the earlier of (i) June 10, 2027 or (ii) the date of the Issuer's 2027 annual meeting of stockholders. The restricted stock units may be settled only by delivering shares of the Issuer's common stock, and thus, the grant is being reported in Table 1 as allowed per SEC guidance.

Read SEC document
June 10, 2026 Filed Jun 12, 2026 21:23 UTC GrantStock Option (Right to Buy) · Derivative 648 $0.00 Strike: $240.66 $0.00
Disclosure

SEC source: 0001689548-26-000059 · wk-form4_1781299435.xml · derivative · entry 2

MITCHELL DEAN J · CIK 0001199297 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 648

Underlying: Common Stock · 648 shares

Expires 2036-06-10

F2 · derivative.exercise_date: The shares subject to this option shall vest in twelve (12) equal monthly installments occurring on the 10th day of each month, with the first such installment occurring on July 10, 2026 and the final such installment occurring on the earlier of (i) June 10, 2027 or (ii) the date of the Issuer's 2027 annual meeting of stockholders.

Read SEC document
June 10, 2026 Filed Jun 12, 2026 21:23 UTC GrantCommon Stock 1,371 $0.00 $0.00
Disclosure

SEC source: 0001689548-26-000059 · wk-form4_1781299435.xml · nonDerivative · entry 1

MITCHELL DEAN J · CIK 0001199297 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,622

F1 · kind: Mr. Mitchell was awarded 1,371 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. The restricted stock units vest in a single annual installment on the earlier of (i) June 10, 2027 or (ii) the date of the Issuer's 2027 annual meeting of stockholders. The restricted stock units may be settled only by delivering shares of the Issuer's common stock, and thus, the grant is being reported in Table 1 as allowed per SEC guidance.

Read SEC document
June 10, 2026 Filed Jun 12, 2026 21:23 UTC GrantStock Option (Right to Buy) · Derivative 648 $0.00 Strike: $240.66 $0.00
Disclosure

SEC source: 0001689548-26-000057 · wk-form4_1781299421.xml · derivative · entry 2

Norden Gregory · CIK 0001405104 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 648

Underlying: Common Stock · 648 shares

Expires 2036-06-10

F2 · derivative.exercise_date: The shares subject to this option shall vest in twelve (12) equal monthly installments occurring on the 10th day of each month, with the first such installment occurring on July 10, 2026 and the final such installment occurring on the earlier of (i) June 10, 2027 or (ii) the date of the Issuer's 2027 annual meeting of stockholders.

Read SEC document
June 10, 2026 Filed Jun 12, 2026 21:23 UTC GrantCommon Stock 1,371 $0.00 $0.00
Disclosure

SEC source: 0001689548-26-000057 · wk-form4_1781299421.xml · nonDerivative · entry 1

Norden Gregory · CIK 0001405104 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,559

F1 · kind: Mr. Norden was awarded 1,371 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. The restricted stock units vest in a single annual installment on the earlier of (i) June 10, 2027 or (ii) the date of the Issuer's 2027 annual meeting of stockholders. The restricted stock units may be settled only by delivering shares of the Issuer's common stock, and thus, the grant is being reported in Table 1 as allowed per SEC guidance.

Read SEC document
May 14, 2026 Filed May 20, 2026 01:44 UTC
Kelly Timothy EdwinChief Financial Officer
GrantCommon Stock 121 $167.94 $20,321.10
Disclosure

SEC source: 0001689548-26-000050 · wk-form4_1779241477.xml · nonDerivative · entry 1

Kelly Timothy Edwin · CIK 0001863297 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,167

F1 · kind: These shares were acquired under the Praxis Precision Medicines, Inc. Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

Read SEC document
May 14, 2026 Filed May 20, 2026 01:43 UTC
Sniecinski MeganChief Operating Officer
GrantCommon Stock 89 $167.94 $14,946.93
Disclosure

SEC source: 0001781480-26-000008 · wk-form4_1779241385.xml · nonDerivative · entry 1

Sniecinski Megan · CIK 0001781480 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,664

F1 · kind: These shares were acquired under the Praxis Precision Medicines, Inc. Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

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May 14, 2026 Filed May 20, 2026 01:42 UTC
Souza MarcioDirector · Chief Executive Officer
GrantCommon Stock 126 $167.94 $21,160.82
Disclosure

SEC source: 0001707657-26-000005 · wk-form4_1779241363.xml · nonDerivative · entry 1

Souza Marcio · CIK 0001707657 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 77,016

F1 · kind: These shares were acquired under the Praxis Precision Medicines, Inc. Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

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May 14, 2026 Filed May 20, 2026 01:45 UTC
Mastrocola LaurenPrincipal Accounting Officer
GrantCommon Stock 127 $167.94 $21,328.76
Disclosure

SEC source: 0001827639-26-000007 · wk-form4_1779241539.xml · nonDerivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,572.656

F1 · kind: These shares were acquired under the Praxis Precision Medicines, Inc. Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

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May 14, 2026 Filed May 20, 2026 01:45 UTC
Nemiroff AlexGeneral Counsel and Secretary
GrantCommon Stock 78 $167.94 $13,099.55
Disclosure

SEC source: 0001827760-26-000007 · wk-form4_1779241516.xml · nonDerivative · entry 1

Nemiroff Alex · CIK 0001827760 · General Counsel and Secretary

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,010.667

F1 · kind: These shares were acquired under the Praxis Precision Medicines, Inc. Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

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February 06, 2026 Filed Feb 10, 2026 21:57 UTC GrantStock Option (Right to Buy) · Derivative 224 $0.00 Strike: $319.57 $0.00
Disclosure

SEC source: 0001689548-26-000017 · wk-form4_1770760657.xml · derivative · entry 3

KINDLER JEFFREY B · CIK 0001174454 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 224

Underlying: Common Stock · 224 shares

Expires 2036-02-06

F3 · derivative.exercise_date: The shares subject to this option shall vest in equal monthly installments occurring on the 26th day of each month, with the first such installment occurring on February 26, 2026 and the final such installment occurring on the earlier of (i) June 26, 2026 or (ii) the date of the Issuer's 2026 annual meeting of stockholders.

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February 06, 2026 Filed Feb 10, 2026 21:57 UTC GrantCommon Stock 478 $0.00 $0.00
Disclosure

SEC source: 0001689548-26-000017 · wk-form4_1770760657.xml · nonDerivative · entry 2

KINDLER JEFFREY B · CIK 0001174454 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,166

F2 · kind: Mr. Kindler was awarded 478 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. The restricted stock units vest in a single annual installment on the earlier of (i) June 26, 2026 or (ii) the date of the Issuer's 2026 annual meeting of stockholders. The restricted stock units may be settled only by delivering shares of the Issuer's common stock, and thus, the grant is being reported in Table 1 as allowed per SEC guidance.

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February 06, 2026 Filed Feb 10, 2026 21:57 UTC GrantCommon Stock 688 $0.00 $0.00
Disclosure

SEC source: 0001689548-26-000017 · wk-form4_1770760657.xml · nonDerivative · entry 1

KINDLER JEFFREY B · CIK 0001174454 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 688

F1 · kind: Mr. Kindler was awarded 688 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. The restricted stock units vest in two equal annual installments occurring on the first two anniversaries of January 8, 2026. The restricted stock units may be settled only by delivering shares of the Issuer's common stock, and thus, the grant is being reported in Table 1 as allowed per SEC guidance.

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February 06, 2026 Filed Feb 10, 2026 21:59 UTC GrantStock Option (Right to Buy) · Derivative 224 $0.00 Strike: $319.57 $0.00
Disclosure

SEC source: 0001689548-26-000018 · wk-form4_1770760770.xml · derivative · entry 3

Arbuckle Stuart A · CIK 0001557290 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 224

Underlying: Common Stock · 224 shares

Expires 2036-02-06

F3 · derivative.exercise_date: The shares subject to this option shall vest in equal monthly installments occurring on the 26th day of each month, with the first such installment occurring on February 26, 2026 and the final such installment occurring on the earlier of (i) June 26, 2026 or (ii) the date of the Issuer's 2026 annual meeting of stockholders.

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February 06, 2026 Filed Feb 10, 2026 21:59 UTC GrantCommon Stock 478 $0.00 $0.00
Disclosure

SEC source: 0001689548-26-000018 · wk-form4_1770760770.xml · nonDerivative · entry 2

Arbuckle Stuart A · CIK 0001557290 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,166

F2 · kind: Mr. Arbuckle was awarded 478 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. The restricted stock units vest in a single annual installment on the earlier of (i) June 26, 2026 or (ii) the date of the Issuer's 2026 annual meeting of stockholders. The restricted stock units may be settled only by delivering shares of the Issuer's common stock, and thus, the grant is being reported in Table 1 as allowed per SEC guidance.

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February 06, 2026 Filed Feb 10, 2026 21:59 UTC GrantCommon Stock 688 $0.00 $0.00
Disclosure

SEC source: 0001689548-26-000018 · wk-form4_1770760770.xml · nonDerivative · entry 1

Arbuckle Stuart A · CIK 0001557290 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 688

F1 · kind: Mr. Arbuckle was awarded 688 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. The restricted stock units vest in two equal annual installments occurring on the first two anniversaries of January 8, 2026. The restricted stock units may be settled only by delivering shares of the Issuer's common stock, and thus, the grant is being reported in Table 1 as allowed per SEC guidance.

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January 12, 2026 Filed Jan 14, 2026 01:18 UTC
Kelly Timothy EdwinChief Financial Officer
Tax withholdingCommon Stock 943 $275.74 $260,022.82
Disclosure

SEC source: 0001863297-26-000005 · wk-form4_1768353511.xml · nonDerivative · entry 1

Kelly Timothy Edwin · CIK 0001863297 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,046

F1 · kind: Shares withheld by the Issuer to satisfy the tax withholding obligations in connection with the vesting of certain previously reported restricted stock units.

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January 12, 2026 Filed Jan 14, 2026 01:19 UTC
Sniecinski MeganChief Operating Officer
Tax withholdingCommon Stock 885 $275.74 $244,029.90
Disclosure

SEC source: 0001781480-26-000006 · wk-form4_1768353587.xml · nonDerivative · entry 1

Sniecinski Megan · CIK 0001781480 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,530

F1 · kind: Shares withheld by the Issuer to satisfy the tax withholding obligations in connection with the vesting of certain previously reported restricted stock units.

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January 12, 2026 Filed Jan 14, 2026 01:20 UTC
Mastrocola LaurenPrincipal Accounting Officer
Tax withholdingCommon Stock 344 $275.74 $94,854.56
Disclosure

SEC source: 0001827639-26-000005 · wk-form4_1768353630.xml · nonDerivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,445.656

F1 · kind: Shares withheld by the Issuer to satisfy the tax withholding obligations in connection with the vesting of certain previously reported restricted stock units.

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January 12, 2026 Filed Jan 14, 2026 01:19 UTC
Nemiroff AlexGeneral Counsel and Secretary
Tax withholdingCommon Stock 768 $275.74 $211,768.32
Disclosure

SEC source: 0001827760-26-000005 · wk-form4_1768353556.xml · nonDerivative · entry 1

Nemiroff Alex · CIK 0001827760 · General Counsel and Secretary

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,932.667

F1 · kind: Shares withheld by the Issuer to satisfy the tax withholding obligations in connection with the vesting of certain previously reported restricted stock units.

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January 10, 2026 Filed Jan 12, 2026 22:49 UTC
Kelly Timothy EdwinChief Financial Officer
Tax withholdingCommon Stock 1,335 $288.45 $385,080.75
Disclosure

SEC source: 0001689548-26-000011 · wk-form4_1768258139.xml · nonDerivative · entry 2

Kelly Timothy Edwin · CIK 0001863297 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,989

F2 · kind: Shares withheld by the Issuer to satisfy the tax withholding obligations in connection with the vesting of certain previously reported restricted stock units.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.