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Mastrocola Lauren

Disclosed activity across 1 company

Tapewire entity
45990
SEC CIK
0001827639

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Reported relationships

Latest disclosed role at each company.

CompanyLast reported asReport datePublished
Praxis Precision Medicines, Inc.PRAX · Entity 3538Principal Accounting OfficerMay 14, 2026May 20, 2026

Disclosed balances

About these balances

Latest available filing per company, not a reconstructed current portfolio. Matching sequences show the last reported balance with all source rows expandable; grouping alone does not establish account ownership. Do not add unresolved positions together. Filings may omit unchanged positions, and amendments may correct only part of an older disclosure. Jointly reported shares are not necessarily this owner's personal holdings.

Praxis Precision Medicines, Inc.

Report date May 14, 2026 · Filed May 20, 2026

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Common StockSEC Table I · non-derivativeDirect13,572.656 Reported balance After 2026-05-14 transaction · row 1
1 source row

Row 1 · 2026-05-14 · Grant · Acquired 127 · Balance 13,572.656

F1: These shares were acquired under the Praxis Precision Medicines, Inc. Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

Filing footnotes · ownership attribution and instrument terms

F1: These shares were acquired under the Praxis Precision Medicines, Inc. Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

Transaction history

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateCompanyActivity / securityShares / unitsReported priceReported valueDetails
May 14, 2026 Filed May 20, 2026 01:45 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 GrantCommon Stock 127 $167.94 $21,328.76
Disclosure

SEC source: 0001827639-26-000007 · wk-form4_1779241539.xml · nonDerivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,572.656

F1 · kind: These shares were acquired under the Praxis Precision Medicines, Inc. Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

Read SEC document
January 12, 2026 Filed Jan 14, 2026 01:20 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Tax withholdingCommon Stock 344 $275.74 $94,854.56
Disclosure

SEC source: 0001827639-26-000005 · wk-form4_1768353630.xml · nonDerivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,445.656

F1 · kind: Shares withheld by the Issuer to satisfy the tax withholding obligations in connection with the vesting of certain previously reported restricted stock units.

Read SEC document
January 10, 2026 Filed Jan 12, 2026 22:51 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Tax withholdingCommon Stock 367 $288.45 $105,861.15
Disclosure

SEC source: 0001689548-26-000014 · wk-form4_1768258260.xml · nonDerivative · entry 2

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,789.656

F2 · kind: Shares withheld by the Issuer to satisfy the tax withholding obligations in connection with the vesting of certain previously reported restricted stock units.

Read SEC document
January 08, 2026 Filed Jan 12, 2026 22:51 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 GrantStock Option (Right to Buy) · Derivative 7,500 $0.00 Strike: $294.38 $0.00
Disclosure

SEC source: 0001689548-26-000014 · wk-form4_1768258260.xml · derivative · entry 3

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,500

Underlying: Common Stock · 7,500 shares

Expires 2036-01-08

F3 · derivative.exercise_date: The shares underlying this stock option vest over a four-year period, with 25% vesting on January 8, 2027 and the remaining 75% vesting in 36 equal monthly installments thereafter, subject to the reporting person's continued service through each vesting date.

Read SEC document
January 08, 2026 Filed Jan 12, 2026 22:51 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 GrantCommon Stock 3,750 $0.00 $0.00
Disclosure

SEC source: 0001689548-26-000014 · wk-form4_1768258260.xml · nonDerivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,156.656

F1 · kind: Ms. Mastrocola was awarded 3,750 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's Common Stock. The restricted stock units vest in equal annual installments over a four-year period beginning on the one-year anniversary of the vesting commencement date of January 8, 2026. The restricted stock units may be settled only by delivering shares of the Issuer's Common Stock, and thus, the grant is being reported in Table 1 as allowed per SEC guidance.

Read SEC document
January 07, 2026 Filed Jan 9, 2026 21:47 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Tax withholdingCommon Stock 35 $292.63 $10,242.05
Disclosure

SEC source: 0001827639-26-000002 · wk-form4_1767995270.xml · nonDerivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,406.656

F1 · kind: Shares withheld by the Issuer to satisfy the tax withholding obligations in connection with the vesting of certain previously reported restricted stock units.

Read SEC document
November 20, 2025 Filed Nov 22, 2025 02:39 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Exercise / conversionStock Option (Right to Buy) · Derivative 5,250 $0.00 Strike: $56.94 $0.00
Disclosure

SEC source: 0001104659-25-115098 · tm2531977-1_4seq1.xml · derivative · entry 16

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,376

Underlying: Common Stock · 5,250 shares

Expires 2034-07-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · derivative.exercise_date: The shares underlying this stock option vested as to 7/48ths on July 29, 2024 and the remaining shares vest in substantially equal monthly installments over the following 41 months, subject to the Reporting Person's continued service through each vesting date.

Read SEC document
November 20, 2025 Filed Nov 22, 2025 02:39 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Exercise / conversionStock Option (Right to Buy) · Derivative 2,351 $0.00 Strike: $44.40 $0.00
Disclosure

SEC source: 0001104659-25-115098 · tm2531977-1_4seq1.xml · derivative · entry 15

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 981

Underlying: Common Stock · 2,351 shares

Expires 2033-01-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F7 · derivative.exercise_date: The shares underlying this stock option vested as to 25% on January 12, 2024 and the remaining shares vest in substantially equal monthly installments over the following 36 months, subject to the Reporting Person's continued service through each vesting date.

Read SEC document
November 20, 2025 Filed Nov 22, 2025 02:39 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Exercise / conversionStock Option (Right to Buy) · Derivative 207 $0.00 Strike: $44.40 $0.00
Disclosure

SEC source: 0001104659-25-115098 · tm2531977-1_4seq1.xml · derivative · entry 14

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 207 shares

Expires 2033-01-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 20, 2025 Filed Nov 22, 2025 02:39 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Exercise / conversionStock Option (Right to Buy) · Derivative 2,680 $0.00 Strike: $43.37 $0.00
Disclosure

SEC source: 0001104659-25-115098 · tm2531977-1_4seq1.xml · derivative · entry 13

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,320

Underlying: Common Stock · 2,680 shares

Expires 2034-01-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The shares underlying this stock option vested as to 50% on January 12, 2024 and the remaining 50% vesting over a four-year period, with 25% of such shares vesting on January 12, 2025 and the remaining vesting in substantially equal monthly installments over the following 36 months, subject to the Reporting Person's continued service through each vesting date.

Read SEC document
November 20, 2025 Filed Nov 22, 2025 02:39 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Exercise / conversionStock Option (Right to Buy) · Derivative 1,557 $0.00 Strike: $133.65 $0.00
Disclosure

SEC source: 0001104659-25-115098 · tm2531977-1_4seq1.xml · derivative · entry 12

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,557 shares

Expires 2030-09-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: This option was fully vested as of September 8, 2024.

Read SEC document
November 20, 2025 Filed Nov 22, 2025 02:39 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Exercise / conversionStock Option (Right to Buy) · Derivative 508 $0.00 Strike: $83.85 $0.00
Disclosure

SEC source: 0001104659-25-115098 · tm2531977-1_4seq1.xml · derivative · entry 11

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 508 shares

Expires 2030-06-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: This option was fully vested as of May 28, 2024.

Read SEC document
November 20, 2025 Filed Nov 22, 2025 02:39 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Exercise / conversionStock Option (Right to Buy) · Derivative 1,047 $0.00 Strike: $49.50 $0.00
Disclosure

SEC source: 0001104659-25-115098 · tm2531977-1_4seq1.xml · derivative · entry 10

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,047 shares

Expires 2029-09-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: This option was fully vested as of January 1, 2023.

Read SEC document
November 20, 2025 Filed Nov 22, 2025 02:39 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 SaleCommon Stock 2,145 $192.71 $413,365.10
Disclosure

SEC source: 0001104659-25-115098 · tm2531977-1_4seq1.xml · nonDerivative · entry 9

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,441.656

F2 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $192.552 to $193.109. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Read SEC document
November 20, 2025 Filed Nov 22, 2025 02:39 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 SaleCommon Stock 11,455 $191.96 $2,198,878.89
Disclosure

SEC source: 0001104659-25-115098 · tm2531977-1_4seq1.xml · nonDerivative · entry 8

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,586.656

F1 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $191.500 to $192.432. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Read SEC document
November 20, 2025 Filed Nov 22, 2025 02:39 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Exercise / conversionCommon Stock 5,250 $56.94 $298,935.00
Disclosure

SEC source: 0001104659-25-115098 · tm2531977-1_4seq1.xml · nonDerivative · entry 7

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,041.656

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 20, 2025 Filed Nov 22, 2025 02:39 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Exercise / conversionCommon Stock 2,351 $44.40 $104,384.40
Disclosure

SEC source: 0001104659-25-115098 · tm2531977-1_4seq1.xml · nonDerivative · entry 6

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,791.656

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 20, 2025 Filed Nov 22, 2025 02:39 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Exercise / conversionCommon Stock 207 $44.40 $9,190.80
Disclosure

SEC source: 0001104659-25-115098 · tm2531977-1_4seq1.xml · nonDerivative · entry 5

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,440.656

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 20, 2025 Filed Nov 22, 2025 02:39 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Exercise / conversionCommon Stock 2,680 $43.37 $116,231.60
Disclosure

SEC source: 0001104659-25-115098 · tm2531977-1_4seq1.xml · nonDerivative · entry 4

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,233.656

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 20, 2025 Filed Nov 22, 2025 02:39 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Exercise / conversionCommon Stock 1,557 $133.65 $208,093.05
Disclosure

SEC source: 0001104659-25-115098 · tm2531977-1_4seq1.xml · nonDerivative · entry 3

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,553.656

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 20, 2025 Filed Nov 22, 2025 02:39 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Exercise / conversionCommon Stock 508 $83.85 $42,595.80
Disclosure

SEC source: 0001104659-25-115098 · tm2531977-1_4seq1.xml · nonDerivative · entry 2

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,996.656

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 20, 2025 Filed Nov 22, 2025 02:39 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Exercise / conversionCommon Stock 1,047 $49.50 $51,826.50
Disclosure

SEC source: 0001104659-25-115098 · tm2531977-1_4seq1.xml · nonDerivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,488.656

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
February 12, 2025 Filed Feb 14, 2025 21:29 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Tax withholdingCommon Stock 40 $85.40 $3,416.00
Disclosure

SEC source: 0001689548-25-000026 · wk-form4_1739568570.xml · nonDerivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,441.656

F1 · kind: Shares withheld by the Issuer to satisfy the tax withholding obligations in connection with the vesting of certain previously reported restricted stock units.

Read SEC document
January 12, 2025 Filed Jan 14, 2025 23:51 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Tax withholdingCommon Stock 390 $63.15 $24,628.50
Disclosure

SEC source: 0001689548-25-000016 · wk-form4_1736898659.xml · nonDerivative · entry 2

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,481.656

F2 · kind: Shares withheld by the Issuer to satisfy the tax withholding obligations in connection with the vesting of certain previously reported restricted stock units.

Read SEC document
January 10, 2025 Filed Jan 14, 2025 23:51 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 GrantStock Option (Right to Buy) · Derivative 10,000 $0.00 Strike: $63.15 $0.00
Disclosure

SEC source: 0001689548-25-000016 · wk-form4_1736898659.xml · derivative · entry 3

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2035-01-10

F3 · derivative.exercise_date: The shares underlying this stock option vest over a four-year period, with 25% vesting on January 10, 2026 and the remaining 75% vesting in 36 equal monthly installments thereafter, subject to the reporting person's continued service through each vesting date.

Read SEC document
January 10, 2025 Filed Jan 14, 2025 23:51 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 GrantCommon Stock 5,000 $0.00 $0.00
Disclosure

SEC source: 0001689548-25-000016 · wk-form4_1736898659.xml · nonDerivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,871.656

F1 · shares: Ms. Mastrocola was awarded 5,000 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's Common Stock. The restricted stock units vest in equal annual installments over a four-year period beginning on the one-year anniversary of the vesting commencement date of January 10, 2025. The restricted stock units may be settled only by delivering shares of the Issuer's Common Stock, and thus, the grant is being reported in Table 1 as allowed per SEC guidance.

Read SEC document
January 07, 2025 Filed Jan 9, 2025 00:50 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Tax withholdingCommon Stock 35 $77.52 $2,713.20
Disclosure

SEC source: 0001689548-25-000007 · wk-form4_1736383818.xml · nonDerivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,871.656

F1 · kind: Shares withheld by the Issuer to satisfy the tax withholding obligations in connection with the vesting of certain previously reported Restricted Share Units.

Read SEC document
November 14, 2024 Filed Nov 16, 2024 02:30 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Exercise / conversionStock Option (Right to Buy) · Derivative 4,374 $0.00 Strike: $56.94 $0.00
Disclosure

SEC source: 0001104659-24-119843 · tm2428636-1_4seq1.xml · derivative · entry 3

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,626

Underlying: Common Stock · 4,374 shares

Expires 2034-07-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The shares underlying this stock option vested as to 7/48ths on July 29, 2024 and the remaining shares vest in substantially equal monthly installments over the following 41 months, subject to the reporting person's continued service through each vesting date.

Read SEC document
November 14, 2024 Filed Nov 16, 2024 02:30 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 SaleCommon Stock 5,188.344 $81.78 $424,318.34
Disclosure

SEC source: 0001104659-24-119843 · tm2428636-1_4seq1.xml · nonDerivative · entry 2

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,612.656

F1 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $81.23 to $81.797. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Read SEC document
November 14, 2024 Filed Nov 16, 2024 02:30 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Exercise / conversionCommon Stock 4,374 $56.94 $249,055.56
Disclosure

SEC source: 0001104659-24-119843 · tm2428636-1_4seq1.xml · nonDerivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,801

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 14, 2024 Filed Nov 20, 2024 02:50 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 GrantCommon Stock 294 $37.40 $10,995.60
Disclosure

SEC source: 0001104659-24-120748 · tm2428929-2_4seq1.xml · nonDerivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 5,906.656

F1 · kind: These shares were acquired under the Praxis Precision Medicines, Inc. Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

Read SEC document
July 29, 2024 Filed Aug 1, 2024 01:01 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 GrantStock Option (Right to Buy) · Derivative 21,000 $0.00 Strike: $56.94 $0.00
Disclosure

SEC source: 0001104659-24-084504 · tm2420554-2_4seq1.xml · derivative · entry 2

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,000

Underlying: Common Stock · 21,000 shares

Expires 2034-07-29

F2 · derivative.exercise_date: The shares underlying this stock option vested as to 7/48ths on July 29, 2024 and the remaining shares vest in substantially equal monthly installments over the following 41 months, subject to the reporting person's continued service through each vesting date.

Read SEC document
July 29, 2024 Filed Aug 1, 2024 01:01 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 GrantCommon Stock 4,500 $0.00 $0.00
Disclosure

SEC source: 0001104659-24-084504 · tm2420554-2_4seq1.xml · nonDerivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,427

F1 · shares: Ms. Mastrocola was awarded 4,500 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's Common Stock. The restricted stock units vest in equal annual installments over a four-year period beginning on January 12, 2025, subject to the reporting person's continued service through each vesting date. The restricted stock units have no expiration date.

Read SEC document
February 12, 2024 Filed Feb 14, 2024 21:14 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Tax withholdingCommon Stock 48 $44.65 $2,143.20
Disclosure

SEC source: 0001689548-24-000027 · wk-form4_1707945236.xml · nonDerivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,927

F1 · kind: Shares withheld by the Issuer to satisfy the tax withholding obligations in connection with the vesting of certain previously reported Restricted Share Units.

Read SEC document
January 12, 2024 Filed Jan 17, 2024 21:47 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 GrantStock Option (Right to Buy) · Derivative 12,000 $0.00 Strike: $43.37 $0.00
Disclosure

SEC source: 0001689548-24-000018 · wk-form4_1705528014.xml · derivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,000

Underlying: Common Stock · 12,000 shares

Expires 2034-01-12

F1 · derivative.exercise_date: The shares underlying this stock option vest as follows: 50% vested in full on January 12, 2024 (the "Grant Date") and the remaining 50% vesting over a four-year period, with 25% of such shares vesting on the first anniversary of the Grant Date and the remaining shares vesting in 36 equal monthly installments thereafter, subject to the reporting person's continued service through each vesting date.

Read SEC document
January 07, 2024 Filed Jan 10, 2024 02:08 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Tax withholdingCommon Stock 35 $25.19 $881.65
Disclosure

SEC source: 0001689548-24-000005 · wk-form4_1704852471.xml · nonDerivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,975

F1 · kind: Shares withheld by the Issuer to satisfy the tax withholding obligations in connection with the vesting of certain previously reported Restricted Share Units.

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February 12, 2023 Filed Feb 14, 2023 01:43 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Tax withholdingCommon Stock 711 $3.94 $2,801.34
Disclosure

SEC source: 0001689548-23-000048 · wf-form4_167633900969675.xml · nonDerivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,160

F1 · kind: Shares withheld by the Issuer to satisfy the tax withholding obligations in connection with the vesting of certain previously reported Restricted Share Units.

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January 12, 2023 Filed Jan 13, 2023 12:43 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 GrantStock Option (Right to Buy) · Derivative 3,110 $0.00 Strike: $2.96 $0.00
Disclosure

SEC source: 0001689548-23-000015 · wf-form4_167361377763317.xml · derivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,110

Underlying: Common Stock · 3,110 shares

Expires 2033-01-12

F1 · shares: Ms. Mastrocola opted to receive this option grant in lieu of a cash bonus for the fiscal year ended December 31, 2022.

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January 12, 2023 Filed Jan 18, 2023 00:30 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 GrantStock Option (Right to Buy) · Derivative 50,000 $0.00 Strike: $2.96 $0.00
Disclosure

SEC source: 0001689548-23-000024 · wf-form4_167400181408222.xml · derivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2033-01-12

F1 · derivative.exercise_date: The shares underlying this stock option vest over a four-year period, with 25% vesting on January 12, 2024 and the remaining 75% vesting in 36 equal monthly installments thereafter, subject to the reporting person's continued service through each vesting date.

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January 07, 2023 Filed Jan 9, 2023 23:16 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Tax withholdingCommon Stock 520 $2.52 $1,310.40
Disclosure

SEC source: 0001689548-23-000006 · wf-form4_167330616920258.xml · nonDerivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,871

F1 · kind: Shares withheld by the Issuer to satisfy the tax withholding obligations in connection with the vesting of certain previously reported Restricted Share Units.

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June 22, 2022 Filed Jun 24, 2022 20:52 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 GrantStock Option (Right to Buy) · Derivative 16,000 $0.00 Strike: $2.12 $0.00
Disclosure

SEC source: 0001689548-22-000094 · wf-form4_165610393075032.xml · derivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,000

Underlying: Common Stock · 16,000 shares

Expires 2032-06-22

F1 · derivative.exercise_date: The shares underlying this stock option vest over a four-year period, with 25% vesting on June 22, 2023 and the remaining 75% vesting in 36 equal monthly installments thereafter, subject to the reporting person's continued service through each vesting date.

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June 16, 2022 Filed Jun 21, 2022 20:35 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 PurchaseCommon Stock 3,000 $1.93 $5,775.00
Disclosure

SEC source: 0001689548-22-000082 · wf-form4_165584373130613.xml · nonDerivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,391

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May 13, 2022 Filed May 18, 2022 21:46 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 GrantCommon Stock 2,557 $8.80 $22,496.49
Disclosure

SEC source: 0001689548-22-000046 · wf-form4_165291013839730.xml · nonDerivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,391

F1 · kind: These shares were acquired under the Praxis Precision Medicines, Inc. Employee Stock Purchase Plan in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c).

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February 12, 2022 Filed Feb 16, 2022 00:35 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Tax withholdingCommon Stock 584 $12.85 $7,504.40
Disclosure

SEC source: 0001689548-22-000005 · wf-form4_164497172165661.xml · nonDerivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,834

F1 · kind: Shares withheld by the Issuer to satisfy the tax withholding obligations in connection with the vesting of certain previously reported Restricted Share Units.

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January 07, 2022 Filed Jan 11, 2022 21:07 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 GrantStock Option (Right to Buy) · Derivative 21,000 $0.00 Strike: $18.11 $0.00
Disclosure

SEC source: 0001104659-22-003158 · tm222494-2_4seq1.xml · derivative · entry 2

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,000

Underlying: Common Stock · 21,000 shares

Expires 2032-01-07

F2 · derivative.exercise_date: The shares underlying this stock option vest over a four-year period, with 25% vesting on January 7, 2023 and the remaining 75% vesting in 36 equal monthly installments thereafter, subject to the reporting person's continued service through each vesting date.

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January 07, 2022 Filed Jan 11, 2022 21:07 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 GrantCommon Stock 6,000 $0.00 $0.00
Disclosure

SEC source: 0001104659-22-003158 · tm222494-2_4seq1.xml · nonDerivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 26,418

F1 · shares: Ms. Mastrocola was awarded 6,000 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's Common Stock. The restricted stock units vest in equal annual installments over a four-year period beginning on January 7, 2023, subject to the reporting person's continued service through each vesting date. The restricted stock units may be settled only by delivering shares of the Issuer's Common Stock, and thus, the grant is being reported in Table 1 as allowed per SEC guidance.

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February 12, 2021 Filed Feb 17, 2021 21:56 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 GrantStock Option (Right to Buy) · Derivative 48,700 $0.00 Strike: $52.53 $0.00
Disclosure

SEC source: 0001689548-21-000011 · wf-form4_161359894605862.xml · derivative · entry 2

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,700

Underlying: Common Stock · 48,700 shares

Expires 2031-02-12

F2 · derivative.exercise_date: The shares underlying this stock option vest over a four-year period, with 27,175 shares vesting on the one-year anniversary of the vesting commencement date of February 12, 2021 and the remaining 21,525 shares vesting in 36 equal monthly installments following such first anniversary, subject to the reporting person's continued service through each vesting date.

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February 12, 2021 Filed Feb 17, 2021 21:56 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 GrantCommon Stock 8,200 $0.00 $0.00
Disclosure

SEC source: 0001689548-21-000011 · wf-form4_161359894605862.xml · nonDerivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,418

F1 · shares: Ms. Mastrocola was awarded 8,200 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's Common Stock. The restricted stock units vest in equal annual installments over a four-year period beginning on the one-year anniversary of the vesting commencement date of February 12, 2021. The restricted stock units may be settled only by delivering shares of the Issuer's Common Stock, and thus, the grant is being reported in Table 1 as allowed per SEC guidance.

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November 02, 2020 Filed Nov 4, 2020 22:32 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Exercise / conversionStock Option (Right to Buy) · Derivative 12,218 $3.30 Strike: $3.30 $40,319.40
Disclosure

SEC source: 0000899243-20-030396 · doc4.xml · derivative · entry 2

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,710

Underlying: Common Stock · 12,218 shares

Expires 2029-09-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: 25% of this option vested and became exercisable on January 1, 2020, with the remainder vesting in 36 equal monthly installments thereafter. This option was initially for 27,928 shares and the Reporting Person has exercised her option to purchase 12,218 shares.

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November 02, 2020 Filed Nov 4, 2020 22:32 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Exercise / conversionCommon Stock 12,218 $3.30 $40,319.40
Disclosure

SEC source: 0000899243-20-030396 · doc4.xml · nonDerivative · entry 1

Mastrocola Lauren · CIK 0001827639 · Principal Accounting Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,218

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.