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person · Reporting owner

DeSimone Jill

Disclosed activity across 4 companies

Tapewire entity
35155
SEC CIK
0001930479

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Reported relationships

Latest disclosed role at each company.

CompanyLast reported asReport datePublished
Oncternal Therapeutics, Inc.ONCT · Entity 89585DirectorJune 20, 2024June 24, 2024
Praxis Precision Medicines, Inc.PRAX · Entity 3538DirectorJune 24, 2026June 26, 2026
iTeos Therapeutics, Inc.ITOS · Entity 75965DirectorJune 11, 2024June 13, 2024

Disclosed balances

About these balances

Latest available filing per company, not a reconstructed current portfolio. Matching sequences show the last reported balance with all source rows expandable; grouping alone does not establish account ownership. Do not add unresolved positions together. Filings may omit unchanged positions, and amendments may correct only part of an older disclosure. Jointly reported shares are not necessarily this owner's personal holdings.

Oncternal Therapeutics, Inc.

Report date June 20, 2024 · Filed June 24, 2024

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Stock OptionsSEC Table II · derivative / convertible security · Conversion / exercise price $8.10 · Expires 2034-06-20Direct2,200 Reported balance After 2024-06-20 transaction · row 1 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 1 · 2024-06-20 · Grant · Acquired 2,200 · Balance 2,200

F1: One-twelfth of the number of shares subject to the option vest and become exercisable in substantially equal installments on each monthly anniversary of the grant date, subject to the Reporting Person's continued service through such vesting date.

Filing footnotes · ownership attribution and instrument terms

F1: One-twelfth of the number of shares subject to the option vest and become exercisable in substantially equal installments on each monthly anniversary of the grant date, subject to the Reporting Person's continued service through such vesting date.

Praxis Precision Medicines, Inc.

Report date June 24, 2026 · Filed June 26, 2026

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Common StockSEC Table I · non-derivativeDirect2,337 Ending reported balance After 2026-06-24 transaction · row 14
14 source rows · reconciled sequence

Row 1 · 2026-06-24 · Exercise / conversion · Acquired 8,566 · Balance 10,903

Row 2 · 2026-06-24 · Exercise / conversion · Acquired 3,034 · Balance 13,937

Row 3 · 2026-06-24 · Sale · Disposed 10 · Balance 13,927

F1: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

Row 4 · 2026-06-24 · Sale · Disposed 120 · Balance 13,807

F1: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F2: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $302.500 to $303.440. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Row 5 · 2026-06-24 · Sale · Disposed 320 · Balance 13,487

F1: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F3: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $305.000 to $305.830. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Row 6 · 2026-06-24 · Sale · Disposed 683 · Balance 12,804

F1: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F4: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $306.365 to $307.180. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Row 7 · 2026-06-24 · Sale · Disposed 1,240 · Balance 11,564

F1: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F5: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $307.900 to $308.870. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Row 8 · 2026-06-24 · Sale · Disposed 999 · Balance 10,565

F1: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F6: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $308.900 to $309.790. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Row 9 · 2026-06-24 · Sale · Disposed 1,750 · Balance 8,815

F1: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F7: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $310.340 to $311.300. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Row 10 · 2026-06-24 · Sale · Disposed 2,854 · Balance 5,961

F1: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F8: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $311.340 to $312.320. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Row 11 · 2026-06-24 · Sale · Disposed 1,004 · Balance 4,957

F1: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F9: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $312.370 to $313.280. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Row 12 · 2026-06-24 · Sale · Disposed 504 · Balance 4,453

F1: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F10: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $313.400 to $314.000. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Row 13 · 2026-06-24 · Sale · Disposed 1,279 · Balance 3,174

F1: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F11: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $314.400 to $315.380. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Row 14 · 2026-06-24 · Sale · Disposed 837 · Balance 2,337

F1: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F12: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $315.590 to $316.010. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Stock Option (Right to Buy)SEC Table II · derivative / convertible security · Conversion / exercise price $44.25 · Expires 2034-06-05Direct0 Reported balance After 2026-06-24 transaction · row 15 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 15 · 2026-06-24 · Exercise / conversion · Disposed 8,566 · Balance 0

F13: This option was fully vested as of June 5, 2025.

Stock Option (Right to Buy)SEC Table II · derivative / convertible security · Conversion / exercise price $147.30 · Expires 2032-05-23Direct0 Reported balance After 2026-06-24 transaction · row 16 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 16 · 2026-06-24 · Exercise / conversion · Disposed 3,034 · Balance 0

F14: This option was fully vested as of May 23, 2025.

Filing footnotes · ownership attribution and instrument terms

F1: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F2: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $302.500 to $303.440. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

F3: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $305.000 to $305.830. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

F4: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $306.365 to $307.180. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

F5: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $307.900 to $308.870. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

F6: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $308.900 to $309.790. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

F7: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $310.340 to $311.300. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

F8: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $311.340 to $312.320. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

F9: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $312.370 to $313.280. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

F10: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $313.400 to $314.000. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

F11: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $314.400 to $315.380. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

F12: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $315.590 to $316.010. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

F13: This option was fully vested as of June 5, 2025.

F14: This option was fully vested as of May 23, 2025.

iTeos Therapeutics, Inc.

Report date June 11, 2024 · Filed June 13, 2024

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Stock Option (Right to Buy)SEC Table II · derivative / convertible security · Conversion / exercise price $16.32 · Expires 2034-06-11Direct24,200 Reported balance After 2024-06-11 transaction · row 1 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 1 · 2024-06-11 · Grant · Acquired 24,200 · Balance 24,200

Past disclosures · reporting ended (1)

No longer tracked through insider filings. These historical balances do not imply present ownership or a zero position.

Kinnate Biopharma Inc.

Report date April 03, 2024 · Filed April 05, 2024

Section 16 reporting ended · disclosed 2024-04-05. Current position is not established by this disclosure.

Security / awardOwnership accountDisclosed shares / unitsDisclosure context
Stock Option (right to buy)SEC Table II · derivative / convertible security · Conversion / exercise price $5.21 · Expires 2033-03-01Direct0 Reported balance After 2024-04-03 transaction · row 1 Instrument identity requires review; Table II rows are not merged.
1 source row

Row 1 · 2024-04-03 · Disposition to issuer · Disposed 50,000 · Balance 0

F1: This option was cancelled pursuant to that certain Agreement and Plan of Merger, dated February 16, 2024, by and between the Issuer, XOMA Corporation and XRA 1 Corp. (the "Merger Agreement") in exchange for one non-transferable contingent value right ("CVR") for each share underlying such out-of-the-money option. However, please note that such CVRs will provide payment only after the amounts payable under such CVRs exceed a threshold equal to the excess of the per share exercise price of such out-of-the-money option over the Cash Amount.

Filing footnotes · ownership attribution and instrument terms

F1: This option was cancelled pursuant to that certain Agreement and Plan of Merger, dated February 16, 2024, by and between the Issuer, XOMA Corporation and XRA 1 Corp. (the "Merger Agreement") in exchange for one non-transferable contingent value right ("CVR") for each share underlying such out-of-the-money option. However, please note that such CVRs will provide payment only after the amounts payable under such CVRs exceed a threshold equal to the excess of the per share exercise price of such out-of-the-money option over the Cash Amount.

Transaction history

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateCompanyActivity / securityShares / unitsReported priceReported valueDetails
June 24, 2026 Filed Jun 26, 2026 21:09 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Exercise / conversionStock Option (Right to Buy) · Derivative 3,034 $0.00 Strike: $147.30 $0.00
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · derivative · entry 16

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,034 shares

Expires 2032-05-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F14 · derivative.exercise_date: This option was fully vested as of May 23, 2025.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Exercise / conversionStock Option (Right to Buy) · Derivative 8,566 $0.00 Strike: $44.25 $0.00
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · derivative · entry 15

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 8,566 shares

Expires 2034-06-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F13 · derivative.exercise_date: This option was fully vested as of June 5, 2025.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 SaleCommon Stock 837 $315.71 $264,245.09
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 14

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,337

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F12 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $315.590 to $316.010. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 SaleCommon Stock 1,279 $314.90 $402,758.38
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 13

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 3,174

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F11 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $314.400 to $315.380. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 SaleCommon Stock 504 $313.66 $158,086.15
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 12

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,453

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F10 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $313.400 to $314.000. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 SaleCommon Stock 1,004 $312.83 $314,081.32
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 11

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,957

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F9 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $312.370 to $313.280. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 SaleCommon Stock 2,854 $311.91 $890,202.56
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 10

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,961

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F8 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $311.340 to $312.320. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 SaleCommon Stock 1,750 $310.89 $544,055.75
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 9

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,815

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F7 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $310.340 to $311.300. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 SaleCommon Stock 999 $309.38 $309,073.62
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 8

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10,565

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F6 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $308.900 to $309.790. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 SaleCommon Stock 1,240 $308.24 $382,221.32
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 7

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 11,564

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F5 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $307.900 to $308.870. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 SaleCommon Stock 683 $306.77 $209,521.86
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 6

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,804

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F4 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $306.365 to $307.180. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 SaleCommon Stock 320 $305.31 $97,699.20
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 5

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 13,487

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F3 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $305.000 to $305.830. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 SaleCommon Stock 120 $303.13 $36,375.24
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 4

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 13,807

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

F2 · price: The price reported is a weighted average price. The securities were sold in multiple transactions at per share prices ranging from $302.500 to $303.440. The Reporting Person undertakes to provide upon request from the SEC staff, the Issuer, or any shareholder of the Issuer, full information regarding the number of securities sold at each separate price within the range set forth in this footnote.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 SaleCommon Stock 10 $301.44 $3,014.40
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 3

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 13,927

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on March 25, 2026.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Exercise / conversionCommon Stock 3,034 $147.30 $446,908.20
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 2

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 13,937

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
June 24, 2026 Filed Jun 26, 2026 21:09 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 Exercise / conversionCommon Stock 8,566 $44.25 $379,045.50
Disclosure

SEC source: 0001930479-26-000003 · wk-form4_1782508155.xml · nonDerivative · entry 1

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10,903

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
June 10, 2026 Filed Jun 12, 2026 21:24 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 GrantStock Option (Right to Buy) · Derivative 648 $0.00 Strike: $240.66 $0.00
Disclosure

SEC source: 0001689548-26-000061 · wk-form4_1781299446.xml · derivative · entry 2

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 648

Underlying: Common Stock · 648 shares

Expires 2036-06-10

F2 · derivative.exercise_date: The shares subject to this option shall vest in twelve (12) equal monthly installments occurring on the 10th day of each month, with the first such installment occurring on July 10, 2026 and the final such installment occurring on the earlier of (i) June 10, 2027 or (ii) the date of the Issuer's 2027 annual meeting of stockholders.

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June 10, 2026 Filed Jun 12, 2026 21:24 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 GrantCommon Stock 1,371 $0.00 $0.00
Disclosure

SEC source: 0001689548-26-000061 · wk-form4_1781299446.xml · nonDerivative · entry 1

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,337

F1 · kind: Ms. DeSimone was awarded 1,371 restricted stock units. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. The restricted stock units vest in a single annual installment on the earlier of (i) June 10, 2027 or (ii) the date of the Issuer's 2027 annual meeting of stockholders. The restricted stock units may be settled only by delivering shares of the Issuer's common stock, and thus, the grant is being reported in Table 1 as allowed per SEC guidance.

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June 26, 2025 Filed Jun 27, 2025 20:55 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 GrantStock Option (Right to Buy) · Derivative 10,520 $0.00 Strike: $44.04 $0.00
Disclosure

SEC source: 0001689548-25-000078 · wk-form4_1751057695.xml · derivative · entry 1

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,520

Underlying: Common Stock · 10,520 shares

Expires 2035-06-26

F1 · derivative.exercise_date: The shares subject to this option shall vest in twelve (12) equal monthly installments over one (1) year commencing on June 26, 2025.

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June 20, 2024 Filed Jun 24, 2024 16:05 UTC Oncternal Therapeutics, Inc. ONCT · Entity 89585 GrantStock Options · Derivative 2,200 $0.00 Strike: $8.10 $0.00
Disclosure

SEC source: 0000950170-24-076704 · ownership.xml · derivative · entry 1

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 2,200

Underlying: Common Stock · 2,200 shares

Expires 2034-06-20

F1 · derivative.exercise_date: One-twelfth of the number of shares subject to the option vest and become exercisable in substantially equal installments on each monthly anniversary of the grant date, subject to the Reporting Person's continued service through such vesting date.

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June 11, 2024 Filed Jun 13, 2024 20:00 UTC iTeos Therapeutics, Inc. ITOS · Entity 75965 GrantStock Option (Right to Buy) · Derivative 24,200 $0.00 Strike: $16.32 $0.00
Disclosure

SEC source: 0000950170-24-073253 · ownership.xml · derivative · entry 1

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,200

Underlying: Common Stock · 24,200 shares

Expires 2034-06-11

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June 05, 2024 Filed Jun 6, 2024 22:56 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 GrantStock Option (Right to Buy) · Derivative 8,566 $0.00 Strike: $44.25 $0.00
Disclosure

SEC source: 0001689548-24-000079 · wk-form4_1717714580.xml · derivative · entry 1

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,566

Underlying: Common Stock · 8,566 shares

Expires 2034-06-05

F1 · derivative.exercise_date: The shares subject to this option shall vest in twelve (12) equal monthly installments over one (1) year commencing on June 5, 2024.

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April 03, 2024 Filed Apr 5, 2024 16:55 UTC Kinnate Biopharma Inc. KNTE · Entity 92187 Disposition to issuerStock Option (right to buy) · Derivative 50,000 Not disclosed Strike: $5.21 Not disclosed
Disclosure

SEC source: 0001415889-24-010425 · form4-04052024_040404.xml · derivative · entry 1

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 50,000 shares

Expires 2033-03-01

F1 · price: This option was cancelled pursuant to that certain Agreement and Plan of Merger, dated February 16, 2024, by and between the Issuer, XOMA Corporation and XRA 1 Corp. (the "Merger Agreement") in exchange for one non-transferable contingent value right ("CVR") for each share underlying such out-of-the-money option. However, please note that such CVRs will provide payment only after the amounts payable under such CVRs exceed a threshold equal to the excess of the per share exercise price of such out-of-the-money option over the Cash Amount.

F1 · derivative.exercise_date: This option was cancelled pursuant to that certain Agreement and Plan of Merger, dated February 16, 2024, by and between the Issuer, XOMA Corporation and XRA 1 Corp. (the "Merger Agreement") in exchange for one non-transferable contingent value right ("CVR") for each share underlying such out-of-the-money option. However, please note that such CVRs will provide payment only after the amounts payable under such CVRs exceed a threshold equal to the excess of the per share exercise price of such out-of-the-money option over the Cash Amount.

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March 07, 2024 Filed Mar 7, 2024 20:01 UTC iTeos Therapeutics, Inc. ITOS · Entity 75965 GrantStock Option (Right to Buy) · Derivative 44,766 $0.00 Strike: $11.58 $0.00
Disclosure

SEC source: 0000950170-24-028264 · ownership.xml · derivative · entry 1

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 44,766

Underlying: Common Stock · 44,766 shares

Expires 2034-03-07

F1 · derivative.exercise_date: This stock option shall vest over 3 years, with 1/3 vesting on March 7, 2025, and thereafter in equal monthly installments over the next 24 months, subject to the Reporting Person's continued service as a director through the applicable vesting date.

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October 05, 2023 Filed Oct 10, 2023 11:41 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 PurchaseCommon Stock 14,500 $1.75 $25,375.00
Disclosure

SEC source: 0001689548-23-000141 · wk-form4_1696938091.xml · nonDerivative · entry 1

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 14,500

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June 28, 2023 Filed Jun 30, 2023 16:00 UTC Oncternal Therapeutics, Inc. ONCT · Entity 89585 GrantStock Options · Derivative 25,000 $0.00 Strike: $0.36 $0.00
Disclosure

SEC source: 0001209191-23-040277 · doc4.xml · derivative · entry 1

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2033-06-28

F1 · derivative.exercise_date: One-twelfth of the number of shares subject to the option vest and become exercisable in substantially equal installments on each monthly anniversary of the grant date, subject to the Reporting Person's continued service through such vesting date.

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June 12, 2023 Filed Jun 14, 2023 11:14 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 GrantStock Option (Right to Buy) · Derivative 28,981 $0.00 Strike: $0.96 $0.00
Disclosure

SEC source: 0001689548-23-000111 · wf-form4_168674123401611.xml · derivative · entry 1

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 28,981

Underlying: Common Stock · 28,981 shares

Expires 2033-06-12

F1 · derivative.exercise_date: The shares subject to this option shall vest in twelve (12) equal monthly installments over one (1) year commencing on June 12, 2023.

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March 01, 2023 Filed Mar 3, 2023 17:54 UTC Kinnate Biopharma Inc. KNTE · Entity 92187 GrantStock Option (right to buy) · Derivative 50,000 $0.00 Strike: $5.21 $0.00
Disclosure

SEC source: 0001209191-23-015865 · doc4.xml · derivative · entry 1

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2033-03-01

F1 · derivative.exercise_date: 1/36th of the shares underlying the Option vest and become exercisable on each monthly anniversary of the Date of Grant.

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January 04, 2023 Filed Jan 5, 2023 18:02 UTC Oncternal Therapeutics, Inc. ONCT · Entity 89585 GrantStock Option · Derivative 50,000 $0.00 Strike: $1.04 $0.00
Disclosure

SEC source: 0001209191-23-002047 · doc4.xml · derivative · entry 1

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2033-01-04

F1 · derivative.exercise_date: The shares subject to the option vest in 36 equal monthly installments with the first installment vesting on February 4, 2023, subject to the recipient's continued service.

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May 23, 2022 Filed May 25, 2022 01:14 UTC Praxis Precision Medicines, Inc. PRAX · Entity 3538 GrantStock Option (Right to Buy) · Derivative 45,511 $0.00 Strike: $9.82 $0.00
Disclosure

SEC source: 0001689548-22-000056 · wf-form4_165344126548499.xml · derivative · entry 1

DeSimone Jill · CIK 0001930479 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,511

Underlying: Common Stock · 45,511 shares

Expires 2032-05-23

F1 · derivative.exercise_date: The shares subject to this option shall vest in thirty-six (36) equal monthly installments over three (3) years commencing on May 23, 2022.

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Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.