PEPG

SEC source: 0000899243-22-017503 · doc4.xml · derivative · entry 1

Svenstrup Niels · CIK 0001922541 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 109,874

Underlying: Common Stock · 109,874 shares

Expires 2032-05-05

F1 · derivative.exercise_date: This option shall vest as follows: twenty-five percent (25%) on the one-year anniversary of the Grant Date and the remainder vesting in thirty-six (36) equal monthly installments, subject to the option recipient's continued service or employment with the Company on each applicable vesting date.

SEC source: 0000899243-22-017491 · doc4.xml · derivative · entry 1

Bracegirdle Sonia · CIK 0001922539 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 79,547

Underlying: Common Stock · 79,547 shares

Expires 2032-05-05

F1 · derivative.exercise_date: This option shall vest as follows: twenty-five percent (25%) on the one-year anniversary of the Grant Date and the remainder vesting in thirty-six (36) equal monthly installments, subject to the option recipient's continued service or employment with the Company on each applicable vesting date.

SEC source: 0000899243-22-017494 · doc4.xml · derivative · entry 1

Goyal Jaya · CIK 0001922548 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 79,920

Underlying: Common Stock · 79,920 shares

Expires 2032-05-05

F1 · derivative.exercise_date: This option shall vest as follows: twenty-five percent (25%) on the one-year anniversary of the Grant Date and the remainder vesting in thirty-six (36) equal monthly installments, subject to the option recipient's continued service or employment with the Company on each applicable vesting date.

SEC source: 0000899243-22-017492 · doc4.xml · derivative · entry 1

Donnelly Noel · CIK 0001922546 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 169,037

Underlying: Common Stock · 169,037 shares

Expires 2032-05-05

F1 · derivative.exercise_date: This option shall vest as follows: twenty-five percent (25%) on the one-year anniversary of the Grant Date and the remainder vesting in thirty-six (36) equal monthly installments, subject to the option recipient's continued service or employment with the Company on each applicable vesting date.

SEC source: 0000899243-22-017502 · doc4.xml · derivative · entry 1

Resnick Joshua · CIK 0001690959 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,667

Underlying: Common Stock · 11,667 shares

Expires 2032-05-05

F1 · derivative.exercise_date: This option shall vest as follows: twenty-five percent (25%) on the one-year anniversary of the Grant Date and the remainder vesting in thirty-six (36) equal monthly installments, subject to the option recipient's continued service or employment with the Company on each applicable vesting date.

F2 · derivative.exercise_date: Under the Reporting Person's arrangement with RA Capital Management, L.P. (the "Adviser"), the Reporting Person holds the stock option for the benefit of the RA Capital Healthcare Fund, L.P. (the "Fund"), RA Capital Nexus Fund II, L.P. (the "Nexus Fund II"), and a separately managed account (the "Account"). The Reporting Person is obligated to turn over to the Adviser any net cash or stock received upon exercise of the stock option, which will offset advisory fees owed by the Fund, the Nexus Fund II, and the Account to the Adviser. The Reporting Person therefore disclaims beneficial ownership of the stock option and underlying Common Stock."

SEC source: 0000899243-22-017498 · doc4.xml · derivative · entry 1

KEATING LAURIE · CIK 0001620743 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,833

Underlying: Common Stock · 5,833 shares

Expires 2032-05-05

F1 · derivative.exercise_date: This option shall vest as follows: twenty-five percent (25%) on the one-year anniversary of the Grant Date and the remainder vesting in thirty-six (36) equal monthly installments, subject to the option recipient's continued service or employment with the Company on each applicable vesting date.

SEC source: 0000899243-22-017495 · doc4.xml · derivative · entry 1

HENSON HEIDI · CIK 0001283301 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,667

Underlying: Common Stock · 11,667 shares

Expires 2032-05-05

F1 · derivative.exercise_date: This option shall vest as follows: twenty-five percent (25%) on the one-year anniversary of the Grant Date and the remainder vesting in thirty-six (36) equal monthly installments, subject to the option recipient's continued service or employment with the Company on each applicable vesting date.

SEC source: 0001104659-22-058268 · tm2215090-1_4seq1.xml · derivative · entry 1

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · Director · 10% owner

RA Capital Nexus Fund II, L.P. · CIK 0001825376 · Director · 10% owner

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

Shah Rajeev M. · CIK 0001619841 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnotes

Disclosed balance after: 11,667

Underlying: Common Stock · 11,667 shares

Expires 2032-05-05

F2 · derivative.exercise_date: This option shall vest as follows: twenty-five percent (25%) on the one-year anniversary of the Grant Date and the remainder vesting in thirty-six (36) equal monthly installments, subject to Josh Resnick's continued service or employment with the Issuer on each applicable vesting date.

F1 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund"), RA Capital Nexus Fund II, L.P. (the "Nexus Fund II") and a separately managed account (the "Account"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. The Adviser, the Adviser GP, Dr. Kolchinsky, and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein.

F2 · ownership.nature: This option shall vest as follows: twenty-five percent (25%) on the one-year anniversary of the Grant Date and the remainder vesting in thirty-six (36) equal monthly installments, subject to Josh Resnick's continued service or employment with the Issuer on each applicable vesting date.

F3 · ownership.nature: Under Dr. Resnick's arrangement with the Adviser, Dr. Resnick holds the option for the benefit of the Fund, the Nexus Fund II and the Account. Dr. Resnick is obligated to turn over to the Adviser any net cash or stock received upon exercise of the option, which will offset advisory fees owed by the Fund, the Nexus Fund II, and the Account to the Adviser. The Reporting Persons therefore disclaim beneficial ownership of the option and underlying common stock.

SEC source: 0000899243-22-017499 · doc4.xml · derivative · entry 1

McArthur James G · CIK 0001763307 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 466,095

Underlying: Common Stock · 466,095 shares

Expires 2032-05-05

F1 · derivative.exercise_date: This option shall vest as follows: twenty-five percent (25%) on the one-year anniversary of the Grant Date and the remainder vesting in thirty-six (36) equal monthly installments, subject to the option recipient's continued service or employment with the Company on each applicable vesting date.

SEC source: 0000899243-22-017489 · doc4.xml · derivative · entry 1

Ashton Christopher · CIK 0001923076 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,667

Underlying: Common Stock · 11,667 shares

Expires 2032-05-05

F1 · derivative.exercise_date: This option shall vest as follows: twenty-five percent (25%) on the one-year anniversary of the Grant Date and the remainder vesting in thirty-six (36) equal monthly installments, subject to the option recipient's continued service or employment with the Company on each applicable vesting date.

SEC source: 0001127602-23-001831 · form4.xml · nonDerivative · entry 1

KEATING LAURIE · CIK 0001620743 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,166