OMER

SEC source: 0000899243-18-000628 · doc4.xml · nonDerivative · entry 3

JACOBSEN MICHAEL A · CIK 0001529087 · VP Finance and CAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,500

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-18-000629 · doc4.xml · derivative · entry 7

Kelbon Marcia S. · CIK 0001472163 · VP Patent and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 69,996

Underlying: Common Stock · 5,004 shares

Expires 2020-03-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: On January 3, 2018, the reporting person paid the exercise price and exercised options to purchase 5,004 shares of the company's common stock. These shares have not been sold and are held for the account of the reporting person. The options previously vested and became exercisable in 48 equal monthly installments, with a vesting commencement date of April 1, 2010.

SEC source: 0000899243-18-000629 · doc4.xml · derivative · entry 6

Kelbon Marcia S. · CIK 0001472163 · VP Patent and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 3,000 shares

Expires 2020-03-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: On January 3, 2018, the reporting person paid the exercise price and exercised options to purchase 3,000 shares of the company's common stock. These shares have not been sold and are held for the account of the reporting person. The options previously vested and became exercisable in 48 equal monthly installments, with a vesting commencement date of November 1, 2009.

SEC source: 0000899243-18-000629 · doc4.xml · derivative · entry 5

Kelbon Marcia S. · CIK 0001472163 · VP Patent and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,972

Underlying: Common Stock · 62,528 shares

Expires 2023-09-24

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The options previously vested and became exercisable in 48 equal monthly installments, with a vesting commencement date of April 1, 2013.

SEC source: 0000899243-18-000629 · doc4.xml · nonDerivative · entry 4

Kelbon Marcia S. · CIK 0001472163 · VP Patent and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 184,645

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-18-000629 · doc4.xml · nonDerivative · entry 3

Kelbon Marcia S. · CIK 0001472163 · VP Patent and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 179,641

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-18-000629 · doc4.xml · nonDerivative · entry 2

Kelbon Marcia S. · CIK 0001472163 · VP Patent and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 176,641

F1 · kind: Open market sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 8, 2017, at which time the trading schedule, including sale periods, price and the number of shares to be sold, was established in accordance with Rule 10b5-1 under the Securities Exchange Act of 1934, as amended.

SEC source: 0000899243-18-000629 · doc4.xml · nonDerivative · entry 1

Kelbon Marcia S. · CIK 0001472163 · VP Patent and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 239,169

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-18-000628 · doc4.xml · derivative · entry 4

JACOBSEN MICHAEL A · CIK 0001529087 · VP Finance and CAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 58,980

Underlying: Common Stock · 1,020 shares

Expires 2023-09-24

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: 25% of the total number of shares subject to this option vested on September 3, 2014, which was the 12-month anniversary of the grant date, and the remaining shares subject to the option vest and become exercisable in equal monthly installments over the 36 months following the initial vesting date.

SEC source: 0000899243-18-000628 · doc4.xml · nonDerivative · entry 2

JACOBSEN MICHAEL A · CIK 0001529087 · VP Finance and CAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,500

F1 · kind: Open market sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 15, 2017, at which time the trading schedule, including sale periods, price and the number of shares to be sold, was established in accordance with Rule 10b5-1 under the Securities Exchange Act of 1934, as amended.

SEC source: 0000899243-18-000628 · doc4.xml · nonDerivative · entry 1

JACOBSEN MICHAEL A · CIK 0001529087 · VP Finance and CAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,520

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-17-029690 · doc4.xml · derivative · entry 4

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 220,039

Underlying: Common Stock · 39,961 shares

Expires 2022-01-08

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: On December 28, 2017, the reporting person paid the exercise price and exercised incentive stock options to purchase 39,961 shares of the company's common stock. These shares have not been sold and are held for the account of the reporting person. This option vested and became exercisable in 48 equal monthly installments. The first installment became exercisable on April 1, 2011 and subsequent installments became exercisable on each monthly anniversary thereafter.

SEC source: 0000899243-17-029690 · doc4.xml · derivative · entry 3

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 102,040 shares

Expires 2017-12-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: On December 28, 2017, the reporting person paid the exercise price and exercised expiring non-qualified stock options to purchase 102,040 shares of the company's common stock. These shares have not been sold and are held for the account of the reporting person. One-fourth of the shares subject to this option vested on December 30, 2008, which was the first anniversary of the grant date, and the remainder became exercisable in equal monthly installments over the following 48 months. In addition to paying the exercise price of the expiring non-qualified stock options, the reporting person is concurrently paying ordinary income taxes incurred as a result of the exercise of these options.

SEC source: 0000899243-17-029690 · doc4.xml · nonDerivative · entry 2

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,026,986

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-17-029690 · doc4.xml · nonDerivative · entry 1

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,987,025

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-17-020739 · doc4.xml · derivative · entry 2

Kelbon Marcia S. · CIK 0001472163 · VP Patent and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,000

Underlying: Common Stock · 8,000 shares

Expires 2020-03-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: On August 21, 2017, the reporting person paid the exercise price and exercised options to purchase 8,000 shares of the company's common stock and held the shares for her account; these shares have not been sold. The options previously vested and became exercisable in 48 equal monthly installments, with a vesting commencement date of April 1, 2010.

SEC source: 0000899243-17-020739 · doc4.xml · nonDerivative · entry 1

Kelbon Marcia S. · CIK 0001472163 · VP Patent and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 176,641

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-17-016622 · doc4.xml · derivative · entry 1

Cable Thomas J. · CIK 0001472158 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2027-06-15

F1 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2018 annual meeting of the shareholders of Omeros Corporation, provided that the participant continues to serve as a director of the company through such date.

SEC source: 0000899243-17-016625 · doc4.xml · derivative · entry 3

JACOBSEN MICHAEL A · CIK 0001529087 · VP Finance and CAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 60,000

Underlying: Common Stock · 14,000 shares

Expires 2023-09-24

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: 25% of the total number of shares subject to this option vested on September 3, 2014, which was the 12-month anniversary of the grant date, and the remaining shares subject to the option vest and become exercisable in equal monthly installments over the 48 months following the initial vesting date.

SEC source: 0000899243-17-016625 · doc4.xml · nonDerivative · entry 2

JACOBSEN MICHAEL A · CIK 0001529087 · VP Finance and CAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,500

F1 · kind: Open market sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 2, 2016, at which time the trading schedule, including sale periods, price and the number of shares to be sold was established in accordance with Rule 10b5-1 under the Securities Exchange Act of 1934, as amended. The closing price of the issuer's common stock on June 2, 2016 was $11.91 per share. This Rule 10b5-1 plan provides for fixed sales of a total of 36,000 shares from August 15, 2016 through August 15, 2017. This sale of 12,000 shares is the result of the third and final trade pursuant to this trading plan.

SEC source: 0000899243-17-016625 · doc4.xml · nonDerivative · entry 1

JACOBSEN MICHAEL A · CIK 0001529087 · VP Finance and CAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,500

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-17-016624 · doc4.xml · derivative · entry 1

Hood Leroy E. MD PhD · CIK 0001472162 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2027-06-15

F1 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2018 annual meeting of the shareholders of Omeros Corporation, provided that the participant continues to serve as a director of the company through such date.

SEC source: 0000899243-17-016623 · doc4.xml · derivative · entry 1

Demopulos Peter A MD · CIK 0001472161 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2027-06-15

F1 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2018 annual meeting of the shareholders of Omeros Corporation, provided that the participant continues to serve as a director of the company through such date.

SEC source: 0000899243-17-016621 · doc4.xml · derivative · entry 1

Shah Rajiv · CIK 0001642407 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2027-06-15

F1 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2018 annual meeting of the shareholders of Omeros Corporation, provided that the participant continues to serve as a director of the company through such date.

SEC source: 0000899243-17-016620 · doc4.xml · derivative · entry 1

Aspiri Ray · CIK 0001472157 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2027-06-15

F1 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2018 annual meeting of the shareholders of Omeros Corporation, provided that the participant continues to serve as a director of the company through such date.

SEC source: 0000899243-17-016619 · doc4.xml · derivative · entry 1

HANISH ARNOLD C · CIK 0001233253 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2027-06-15

F1 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2018 annual meeting of the shareholders of Omeros Corporation, provided that the participant continues to serve as a director of the company through such date.

SEC source: 0000899243-17-016504 · doc4.xml · derivative · entry 9

JACOBSEN MICHAEL A · CIK 0001529087 · VP Finance and CAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 74,000

Underlying: Common Stock · 14,000 shares

Expires 2023-09-24

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: 25% of the total number of shares subject to this option vested on September 3, 2014, which was the 12-month anniversary of the grant date, and the remaining shares subject to the option vest and become exercisable in equal monthly installments over the 48 months following the initial vesting date.

SEC source: 0000899243-17-016504 · doc4.xml · nonDerivative · entry 6

JACOBSEN MICHAEL A · CIK 0001529087 · VP Finance and CAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,500

F1 · kind: Open market sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 2, 2016, at which time the trading schedule, including sale periods, price and the number of shares to be sold was established in accordance with Rule 10b5-1 under the Securities Exchange Act of 1934, as amended. The closing price of the issuer's common stock on June 2, 2016 was $11.91 per share. This Rule 10b5-1 plan provides for fixed sales of a total of 36,000 shares from August 15, 2016 through August 15, 2017.

SEC source: 0000899243-17-016504 · doc4.xml · nonDerivative · entry 5

JACOBSEN MICHAEL A · CIK 0001529087 · VP Finance and CAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,500

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-17-016504 · doc4.xml · derivative · entry 8

JACOBSEN MICHAEL A · CIK 0001529087 · VP Finance and CAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 88,000

Underlying: Common Stock · 12,850 shares

Expires 2023-09-24

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: 25% of the total number of shares subject to this option vested on September 3, 2014, which was the 12-month anniversary of the grant date, and the remaining shares subject to the option vest and become exercisable in equal monthly installments over the 48 months following the initial vesting date.

SEC source: 0000899243-17-016504 · doc4.xml · nonDerivative · entry 4

JACOBSEN MICHAEL A · CIK 0001529087 · VP Finance and CAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,500

F1 · kind: Open market sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 2, 2016, at which time the trading schedule, including sale periods, price and the number of shares to be sold was established in accordance with Rule 10b5-1 under the Securities Exchange Act of 1934, as amended. The closing price of the issuer's common stock on June 2, 2016 was $11.91 per share. This Rule 10b5-1 plan provides for fixed sales of a total of 36,000 shares from August 15, 2016 through August 15, 2017.

SEC source: 0000899243-17-016504 · doc4.xml · nonDerivative · entry 3

JACOBSEN MICHAEL A · CIK 0001529087 · VP Finance and CAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,850

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-17-016504 · doc4.xml · derivative · entry 7

JACOBSEN MICHAEL A · CIK 0001529087 · VP Finance and CAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,850

Underlying: Common Stock · 2,650 shares

Expires 2023-09-24

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: 25% of the total number of shares subject to this option vested on September 3, 2014, which was the 12-month anniversary of the grant date, and the remaining shares subject to the option vest and become exercisable in equal monthly installments over the 48 months following the initial vesting date.

SEC source: 0000899243-17-016504 · doc4.xml · nonDerivative · entry 2

JACOBSEN MICHAEL A · CIK 0001529087 · VP Finance and CAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: Open market sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 2, 2016, at which time the trading schedule, including sale periods, price and the number of shares to be sold was established in accordance with Rule 10b5-1 under the Securities Exchange Act of 1934, as amended. The closing price of the issuer's common stock on June 2, 2016 was $11.91 per share. This Rule 10b5-1 plan provides for fixed sales of a total of 36,000 shares from August 15, 2016 through August 15, 2017.

SEC source: 0000899243-17-016504 · doc4.xml · nonDerivative · entry 1

JACOBSEN MICHAEL A · CIK 0001529087 · VP Finance and CAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,650

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-17-010302 · doc4.xml · nonDerivative · entry 1

Cable Thomas J. · CIK 0001472158 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,067

F1 · kind: Open market sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 19, 2016, at which time the trading schedule, including sale periods and the number of shares to be sold, was established in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. This Rule 10b5-1 plan provides for fixed sales of a total of 9,000 shares over a one-year period beginning on August 12, 2016 and ending May 20, 2017, with sale periods commencing approximately every four months. This sale of 3,000 shares is the result of the third and final trade pursuant to this trading plan.

F2 · price: This transaction was executed in multiple trades at prices ranging from $15.97 to $16.73; the price reported above reflects the weighted average sales price. The reporting person hereby undertakes to provide full information regarding the number of shares and prices at which the transactions referenced in this footnote were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.

SEC source: 0000899243-17-008378 · doc4.xml · derivative · entry 2

Kelbon Marcia S. · CIK 0001472163 · VP Patent and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,000

Underlying: Common Stock · 2,040 shares

Expires 2020-03-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: On March 20, 2017, the reporting person paid the exercise price and exercised options to purchase 2,040 shares of the company's common stock and held the shares for her account; these shares have not been sold. The options previously vested and became exercisable in 48 equal monthly installments, with a vesting commencement date of April 1, 2010.

SEC source: 0000899243-17-008378 · doc4.xml · nonDerivative · entry 1

Kelbon Marcia S. · CIK 0001472163 · VP Patent and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 168,641

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-17-005672 · doc4.xml · derivative · entry 1

Kelbon Marcia S. · CIK 0001472163 · VP Patent and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2027-02-25

F1 · derivative.exercise_date: The option vests and becomes exercisable over 48 equal monthly installments, with a vesting commencement date of February 26, 2017. Installments vest and become exercisable on each monthly anniversary thereafter.

SEC source: 0000899243-17-005674 · doc4.xml · derivative · entry 1

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 375,000

Underlying: Common Stock · 375,000 shares

Expires 2027-02-25

F1 · derivative.exercise_date: The option vests and becomes exercisable over 48 equal monthly installments, with a vesting commencement date of February 26, 2017. Installments vest and become exercisable on each monthly anniversary thereafter.

SEC source: 0000899243-17-005670 · doc4.xml · derivative · entry 1

JACOBSEN MICHAEL A · CIK 0001529087 · VP Finance and CAO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 70,000

Underlying: Common Stock · 70,000 shares

Expires 2027-02-25

F1 · derivative.exercise_date: The option vests and becomes exercisable over 48 equal monthly installments, with a vesting commencement date of February 26, 2017. Installments vest and become exercisable on each monthly anniversary thereafter.

SEC source: 0000899243-16-035870 · doc4.xml · nonDerivative · entry 1

Cable Thomas J. · CIK 0001472158 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 43,067

F1 · kind: Open market sale pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 19, 2016, at which time the trading schedule, including sale periods and the number of shares to be sold, was established in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. This Rule 10b5-1 plan provides for fixed sales of a total of 9,000 shares over a one-year period beginning on August 12, 2016 and ending May 20, 2017, with sale periods commencing approximately every four months. This sale of 3,000 shares is the result of the second trade pursuant to this trading plan.

F2 · price: This transaction was executed in multiple trades at prices ranging from $10.02 to $10.32; the price reported above reflects the weighted average sales price. The reporting person hereby undertakes to provide full information regarding the number of shares and prices at which the transactions referenced in this footnote were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.

SEC source: 0000899243-16-035087 · doc4.xml · derivative · entry 10

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 102,044 shares

Expires 2016-12-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The option vested and became exercisable in 48 equal monthly installments. The first installment became exercisable on March 28, 2005 and subsequent installments became exercisable on each monthly anniversary thereafter.

SEC source: 0000899243-16-035087 · doc4.xml · nonDerivative · entry 6

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,884,985

F1 · kind: Open market sale pursuant to a Rule 10b5-1 trading plan adopted earlier this year by the reporting person that provides for the exercise and sale of options to purchase 612,244 shares of common stock that expire on December 11, 2016 and 100 shares of common stock that expire on April 7, 2020; the latter at a threshold price of $100.00 per share. Under the plan, the options expiring on December 11, 2016, which do not provide for an extension of the exercise period, would be exercised and sold during fixed sale periods at specified prices and numbers in each sale period. The 306,124 shares of common stock sold during this reporting period complete the sale of all shares associated with the options expiring on December 11, 2016. Consistent with the applicable trading rules, the reporting person has had no further control over the terms or timing of sales under the plan.

F2 · kind: (Continued from Footnote 1) A portion of the proceeds from the exercise of the options expiring on December 11, 2016, all of which are non-qualified, are being used to fund in part the reporting person's exercise of all incentive stock options that otherwise would expire on December 11, 2016.

F5 · price: This transaction was executed in multiple trades at prices ranging from $10.26 to $10.78; the price reported above reflects the weighted average sales price. The reporting person hereby undertakes to provide full information regarding the number of shares and prices at which the transactions referenced in this footnote were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.

SEC source: 0000899243-16-035087 · doc4.xml · nonDerivative · entry 5

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,987,029

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-16-035087 · doc4.xml · derivative · entry 9

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 102,044

Underlying: Common Stock · 102,040 shares

Expires 2016-12-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_date: The option vested and became exercisable in 48 equal monthly installments. The first installment became exercisable on March 28, 2005 and subsequent installments became exercisable on each monthly anniversary thereafter.

SEC source: 0000899243-16-035087 · doc4.xml · nonDerivative · entry 4

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,884,985

F1 · kind: Open market sale pursuant to a Rule 10b5-1 trading plan adopted earlier this year by the reporting person that provides for the exercise and sale of options to purchase 612,244 shares of common stock that expire on December 11, 2016 and 100 shares of common stock that expire on April 7, 2020; the latter at a threshold price of $100.00 per share. Under the plan, the options expiring on December 11, 2016, which do not provide for an extension of the exercise period, would be exercised and sold during fixed sale periods at specified prices and numbers in each sale period. The 306,124 shares of common stock sold during this reporting period complete the sale of all shares associated with the options expiring on December 11, 2016. Consistent with the applicable trading rules, the reporting person has had no further control over the terms or timing of sales under the plan.

F2 · kind: (Continued from Footnote 1) A portion of the proceeds from the exercise of the options expiring on December 11, 2016, all of which are non-qualified, are being used to fund in part the reporting person's exercise of all incentive stock options that otherwise would expire on December 11, 2016.

F4 · price: This transaction was executed in multiple trades at prices ranging from $10.45 to $11.13; the price reported above reflects the weighted average sales price. The reporting person hereby undertakes to provide full information regarding the number of shares and prices at which the transactions referenced in this footnote were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.

SEC source: 0000899243-16-035087 · doc4.xml · nonDerivative · entry 3

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,987,025

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-16-035088 · doc4.xml · derivative · entry 1

Kelbon Marcia S. · CIK 0001472163 · VP Patent and General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,000

Underlying: Common Stock · 80,000 shares

Expires 2026-12-04

F1 · derivative.exercise_date: The option vests and becomes exercisable over 48 equal monthly installments, with a vesting commencement date of April 1, 2016. Installments vest and become exercisable on each monthly anniversary thereafter.

SEC source: 0000899243-16-035087 · doc4.xml · derivative · entry 8

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 400,000

Underlying: Common Stock · 400,000 shares

Expires 2026-12-04

F7 · derivative.exercise_date: The option vests and becomes exercisable over 48 equal monthly installments, with a vesting commencement date of April 1, 2016. Installments vest and become exercisable on each monthly anniversary thereafter.