OMER

SEC source: 0001437749-26-018625 · rdgdoc.xml · derivative · entry 3

Cable Thomas J. · CIK 0001472158 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 7,500 shares

Expires 2026-06-09

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001437749-26-018625 · rdgdoc.xml · nonDerivative · entry 2

Cable Thomas J. · CIK 0001472158 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 35,067

F1 · kind: Open market sale pursuant to a previously established Rule 10b5-1 trading plan adopted by the reporting person on June 14, 2024. The trading schedule, including sale periods and the number of shares to be sold, was established at the time of the trading plan's adoption in accordance with Rule 10b5-1 under the Securities Exchange Act of 1934, as amended. The shares sold were acquired upon the exercise of vested stock options scheduled to expire on June 9, 2026.

F2 · price: This transaction was executed in multiple trades at prices ranging from $11.46 to $11.93. The price reported above reflects the weighted average sales price. The reporting person hereby undertakes to provide full information regarding the number of shares and prices at which the transactions referenced in this footnote were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.

SEC source: 0001437749-26-018625 · rdgdoc.xml · nonDerivative · entry 1

Cable Thomas J. · CIK 0001472158 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 42,567

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001437749-26-004950 · rdgdoc.xml · derivative · entry 6

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common stock · 400,000 shares

Expires 2026-02-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_date: This option vested and became exercisable over 48 equal monthly installments, with a vesting commencement date of April 1, 2015.

SEC source: 0001437749-26-004950 · rdgdoc.xml · nonDerivative · entry 2

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,469,308

F1 · shares: Represents shares withheld by Omeros Corporation ("Omeros") in connection with net share settlement to satisfy the exercise price and tax liability associated with the reporting person's exercise of stock options. The number of shares withheld was determined based on the closing price of Omeros' common stock on February 17, 2026. The transaction did not involve any open-market sale of securities, and all 357,678 withheld shares remained in the Omeros treasury.

SEC source: 0001437749-26-004950 · rdgdoc.xml · nonDerivative · entry 1

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,826,986

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001437749-26-001280 · rdgdoc.xml · derivative · entry 4

Borges David J. · CIK 0002005787 · VP, Finance & CAO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 65,000

Underlying: Common Stock · 30,000 shares

Expires 2034-04-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: This option vests and becomes exercisable over 48 equal monthly installments, with a vesting commencement date of April 1, 2024. Installments vest and become exercisable on each monthly anniversary thereafter.

SEC source: 0001437749-26-001280 · rdgdoc.xml · nonDerivative · entry 3

Borges David J. · CIK 0002005787 · VP, Finance & CAO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F2 · price: This transaction was executed in multiple trades at prices ranging from $12.13 to $12.62. The price reported above reflects the weighted average sales price. The reporting person hereby undertakes to provide full information regarding the number of shares and prices at which the transactions referenced in this footnote were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.

SEC source: 0001437749-26-001280 · rdgdoc.xml · nonDerivative · entry 2

Borges David J. · CIK 0002005787 · VP, Finance & CAO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001437749-26-001280 · rdgdoc.xml · nonDerivative · entry 1

Borges David J. · CIK 0002005787 · VP, Finance & CAO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F1 · price: This transaction was executed in multiple trades at prices ranging from $12.56 to $13.06. The price reported above reflects the weighted average sales price. The reporting person hereby undertakes to provide full information regarding the number of shares and prices at which the transactions referenced in this footnote were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.

SEC source: 0001437749-25-031087 · rdgdoc.xml · nonDerivative · entry 3

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: No plan indicated

Ownership: Indirect · By trust

Disclosed balance after: 300,000

F1 · kind: The reporting person made bona fide gifts of Omeros Corporation common stock, each of 300,000 shares, to separate irrevocable trusts established for the benefit of each of the reporting person's two minor children.

F2 · balance_after: The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, if any, and nothing in this report shall be deemed an admission that the reporting person is the beneficial owner of such securities under Section 16 of the Securities Exchange Act of 1934 or for any other purpose.

F4 · ownership.nature: Shares held in the [Demopulos Child #2] Gift Trust, an irrevocable trust established for the benefit of a minor child of the reporting person.

SEC source: 0001437749-25-031087 · rdgdoc.xml · nonDerivative · entry 2

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: No plan indicated

Ownership: Indirect · By trust

Disclosed balance after: 300,000

F1 · kind: The reporting person made bona fide gifts of Omeros Corporation common stock, each of 300,000 shares, to separate irrevocable trusts established for the benefit of each of the reporting person's two minor children.

F2 · balance_after: The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, if any, and nothing in this report shall be deemed an admission that the reporting person is the beneficial owner of such securities under Section 16 of the Securities Exchange Act of 1934 or for any other purpose.

F3 · ownership.nature: Shares held in the [Demopulos Child #1] Gift Trust, an irrevocable trust established for the benefit of a minor child of the reporting person.

SEC source: 0001437749-25-031087 · rdgdoc.xml · nonDerivative · entry 1

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,426,986

F1 · kind: The reporting person made bona fide gifts of Omeros Corporation common stock, each of 300,000 shares, to separate irrevocable trusts established for the benefit of each of the reporting person's two minor children.

SEC source: 0001437749-25-021803 · rdgdoc.xml · derivative · entry 1

Borges David J. · CIK 0002005787 · VP, Finance & CAO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 95,000

Underlying: Common Stock · 95,000 shares

Expires 2035-06-30

F1 · derivative.exercise_date: This option shall vest and become exercisable over 48 equal monthly installments, with a vesting commencement date of April 1, 2025. Installments vest and become exercisable on each monthly anniversary thereafter.

SEC source: 0001437749-25-021808 · rdgdoc.xml · derivative · entry 1

Cancelmo Peter B · CIK 0001778968 · VP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2035-06-30

F1 · derivative.exercise_date: This option shall vest and become exercisable over 48 equal monthly installments, with a vesting commencement date of April 1, 2025. Installments vest and become exercisable on each monthly anniversary thereafter.

SEC source: 0001437749-25-021814 · rdgdoc.xml · derivative · entry 1

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 865,000

Underlying: Common Stock · 865,000 shares

Expires 2035-06-30

F1 · derivative.exercise_date: This option shall vest and become exercisable over 48 equal monthly installments, with a vesting commencement date of April 1, 2025. Installments vest and become exercisable on each monthly anniversary thereafter.

SEC source: 0001437749-25-021797 · rdgdoc.xml · derivative · entry 1

Perkinson Diana T. · CIK 0001976830 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2035-06-27

F1 · security: Pursuant to Omeros Corporation's non-employee director compensation policy, on the date of each annual meeting of shareholders, each non-employee director who has served as a director for at least six months and who will continue to serve as a director after the annual meeting is automatically granted an option to purchase 15,000 shares of common stock. This Form 4 reports the annual stock option award granted to the reporting person in conjunction with the annual meeting of shareholders held on June 27, 2025.

F2 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2026 annual meeting of the shareholders of Omeros Corporation, provided that the reporting person continues to serve as a director of the company through such date.

SEC source: 0001437749-25-021784 · rdgdoc.xml · derivative · entry 1

Cable Thomas J. · CIK 0001472158 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2035-06-27

F1 · security: Pursuant to Omeros Corporation's non-employee director compensation policy, on the date of each annual meeting of shareholders, each non-employee director who has served as a director for at least six months and who will continue to serve as a director after the annual meeting is automatically granted an option to purchase 15,000 shares of common stock. This Form 4 reports the annual stock option award granted to the reporting person in conjunction with the annual meeting of shareholders held on June 27, 2025.

F2 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2026 annual meeting of the shareholders of Omeros Corporation, provided that the reporting person continues to serve as a director of the company through such date.

SEC source: 0001437749-25-021795 · rdgdoc.xml · derivative · entry 1

Hood Leroy E. MD PhD · CIK 0001472162 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2035-06-27

F1 · security: Pursuant to Omeros Corporation's non-employee director compensation policy, on the date of each annual meeting of shareholders, each non-employee director who has served as a director for at least six months and who will continue to serve as a director after the annual meeting is automatically granted an option to purchase 15,000 shares of common stock. This Form 4 reports the annual stock option award granted to the reporting person in conjunction with the annual meeting of shareholders held on June 27, 2025.

F2 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2026 annual meeting of the shareholders of Omeros Corporation, provided that the reporting person continues to serve as a director of the company through such date.

SEC source: 0001437749-25-021801 · rdgdoc.xml · derivative · entry 1

Shah Rajiv · CIK 0001642407 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2035-06-27

F1 · security: Pursuant to Omeros Corporation's non-employee director compensation policy, on the date of each annual meeting of shareholders, each non-employee director who has served as a director for at least six months and who will continue to serve as a director after the annual meeting is automatically granted an option to purchase 15,000 shares of common stock. This Form 4 reports the annual stock option award granted to the reporting person in conjunction with the annual meeting of shareholders held on June 27, 2025.

F2 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2026 annual meeting of the shareholders of Omeros Corporation, provided that the reporting person continues to serve as a director of the company through such date.

SEC source: 0001437749-25-021792 · rdgdoc.xml · derivative · entry 1

HANISH ARNOLD C · CIK 0001233253 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2035-06-27

F1 · security: Pursuant to Omeros Corporation's non-employee director compensation policy, on the date of each annual meeting of shareholders, each non-employee director who has served as a director for at least six months and who will continue to serve as a director after the annual meeting is automatically granted an option to purchase 15,000 shares of common stock. This Form 4 reports the annual stock option award granted to the reporting person in conjunction with the annual meeting of shareholders held on June 27, 2025.

F2 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2026 annual meeting of the shareholders of Omeros Corporation, provided that the reporting person continues to serve as a director of the company through such date.

SEC source: 0001437749-25-021781 · rdgdoc.xml · derivative · entry 1

Bumol Thomas F. · CIK 0001767077 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2035-06-27

F1 · security: Pursuant to Omeros Corporation's non-employee director compensation policy, on the date of each annual meeting of shareholders, each non-employee director who has served as a director for at least six months and who will continue to serve as a director after the annual meeting is automatically granted an option to purchase 15,000 shares of common stock. This Form 4 reports the annual stock option award granted to the reporting person in conjunction with the annual meeting of shareholders held on June 27, 2025.

F2 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2026 annual meeting of the shareholders of Omeros Corporation, provided that the reporting person continues to serve as a director of the company through such date.

SEC source: 0001437749-25-021789 · rdgdoc.xml · derivative · entry 1

Demopulos Peter A MD · CIK 0001472161 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2035-06-27

F1 · security: Pursuant to Omeros Corporation's non-employee director compensation policy, on the date of each annual meeting of shareholders, each non-employee director who has served as a director for at least six months and who will continue to serve as a director after the annual meeting is automatically granted an option to purchase 15,000 shares of common stock. This Form 4 reports the annual stock option award granted to the reporting person in conjunction with the annual meeting of shareholders held on June 27, 2025.

F2 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2026 annual meeting of the shareholders of Omeros Corporation, provided that the reporting person continues to serve as a director of the company through such date.

SEC source: 0001437749-24-019711 · rdgdoc.xml · derivative · entry 1

Perkinson Diana T. · CIK 0001976830 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2034-06-06

F1 · security: Pursuant to Omeros Corporation's non-employee director compensation policy, on the date of each annual meeting of shareholders, each non-employee director who has served as a director for at least six months and who will continue to serve as a director after the annual meeting is automatically granted an option to purchase 15,000 shares of common stock. This Form 4 reports the annual stock option award granted to the reporting person in conjunction with the annual meeting of shareholders held on June 6, 2024.

F2 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2025 annual meeting of the shareholders of Omeros Corporation, provided that the reporting person continues to serve as a director of the company through such date.

SEC source: 0001437749-24-019702 · rdgdoc.xml · derivative · entry 1

Cable Thomas J. · CIK 0001472158 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2034-06-06

F1 · security: Pursuant to Omeros Corporation's non-employee director compensation policy, on the date of each annual meeting of shareholders, each non-employee director who has served as a director for at least six months and who will continue to serve as a director after the annual meeting is automatically granted an option to purchase 15,000 shares of common stock. This Form 4 reports the annual stock option award granted to the reporting person in conjunction with the annual meeting of shareholders held on June 6, 2024.

F2 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2025 annual meeting of the shareholders of Omeros Corporation, provided that the reporting person continues to serve as a director of the company through such date.

SEC source: 0001437749-24-019713 · rdgdoc.xml · derivative · entry 1

Shah Rajiv · CIK 0001642407 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2034-06-06

F1 · security: Pursuant to Omeros Corporation's non-employee director compensation policy, on the date of each annual meeting of shareholders, each non-employee director who has served as a director for at least six months and who will continue to serve as a director after the annual meeting is automatically granted an option to purchase 15,000 shares of common stock. This Form 4 reports the annual stock option award granted to the reporting person in conjunction with the annual meeting of shareholders held on June 6, 2024.

F2 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2025 annual meeting of the shareholders of Omeros Corporation, provided that the reporting person continues to serve as a director of the company through such date.

SEC source: 0001437749-24-019709 · rdgdoc.xml · derivative · entry 1

Hood Leroy E. MD PhD · CIK 0001472162 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2034-06-06

F1 · security: Pursuant to Omeros Corporation's non-employee director compensation policy, on the date of each annual meeting of shareholders, each non-employee director who has served as a director for at least six months and who will continue to serve as a director after the annual meeting is automatically granted an option to purchase 15,000 shares of common stock. This Form 4 reports the annual stock option award granted to the reporting person in conjunction with the annual meeting of shareholders held on June 6, 2024.

F2 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2025 annual meeting of the shareholders of Omeros Corporation, provided that the reporting person continues to serve as a director of the company through such date.

SEC source: 0001437749-24-019707 · rdgdoc.xml · derivative · entry 1

HANISH ARNOLD C · CIK 0001233253 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2034-06-06

F1 · security: Pursuant to Omeros Corporation's non-employee director compensation policy, on the date of each annual meeting of shareholders, each non-employee director who has served as a director for at least six months and who will continue to serve as a director after the annual meeting is automatically granted an option to purchase 15,000 shares of common stock. This Form 4 reports the annual stock option award granted to the reporting person in conjunction with the annual meeting of shareholders held on June 6, 2024.

F2 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2025 annual meeting of the shareholders of Omeros Corporation, provided that the reporting person continues to serve as a director of the company through such date.

SEC source: 0001437749-24-019705 · rdgdoc.xml · derivative · entry 1

Demopulos Peter A MD · CIK 0001472161 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2034-06-06

F1 · security: Pursuant to Omeros Corporation's non-employee director compensation policy, on the date of each annual meeting of shareholders, each non-employee director who has served as a director for at least six months and who will continue to serve as a director after the annual meeting is automatically granted an option to purchase 15,000 shares of common stock. This Form 4 reports the annual stock option award granted to the reporting person in conjunction with the annual meeting of shareholders held on June 6, 2024.

F2 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2025 annual meeting of the shareholders of Omeros Corporation, provided that the reporting person continues to serve as a director of the company through such date.

SEC source: 0001437749-24-019700 · rdgdoc.xml · derivative · entry 1

Bumol Thomas F. · CIK 0001767077 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2034-06-06

F1 · security: Pursuant to Omeros Corporation's non-employee director compensation policy, on the date of each annual meeting of shareholders, each non-employee director who has served as a director for at least six months and who will continue to serve as a director after the annual meeting is automatically granted an option to purchase 15,000 shares of common stock. This Form 4 reports the annual stock option award granted to the reporting person in conjunction with the annual meeting of shareholders held on June 6, 2024.

F2 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2025 annual meeting of the shareholders of Omeros Corporation, provided that the reporting person continues to serve as a director of the company through such date.

SEC source: 0001437749-24-013735 · rdgdoc.xml · derivative · entry 1

Cancelmo Peter B · CIK 0001778968 · VP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2034-04-25

F1 · derivative.exercise_date: This option shall vest and become exercisable over 48 equal monthly installments, with a vesting commencement date of April 1, 2024. Installments vest and become exercisable on each monthly anniversary thereafter.

SEC source: 0001437749-24-013751 · rdgdoc.xml · derivative · entry 1

Demopulos Gregory A MD · CIK 0001472160 · Director · Chairman, CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 725,000

Underlying: Common Stock · 725,000 shares

Expires 2034-04-25

F1 · derivative.exercise_date: This option shall vest and become exercisable over 48 equal monthly installments, with a vesting commencement date of April 1, 2024. Installments vest and become exercisable on each monthly anniversary thereafter.

SEC source: 0001437749-24-013746 · rdgdoc.xml · derivative · entry 1

JACOBSEN MICHAEL A · CIK 0001529087 · VP, Finance & CAO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2034-04-25

F1 · derivative.exercise_date: This option shall vest and become exercisable over 48 equal monthly installments, with a vesting commencement date of April 1, 2024. Installments vest and become exercisable on each monthly anniversary thereafter.

SEC source: 0001437749-23-032809 · rdgdoc.xml · nonDerivative · entry 1

Demopulos Gregory A MD · CIK 0001472160 · Chairman, CEO & President

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse

Disclosed balance after: 123,945

F1 · balance_after: The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, if any, and nothing in this report shall be deemed an admission that the reporting person is the beneficial owner of such securities under Section 16 of the Securities Exchange Act of 1934 or for any other purpose.

SEC source: 0001437749-23-032515 · rdgdoc.xml · nonDerivative · entry 1

Demopulos Peter A MD · CIK 0001472161 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 208,516

SEC source: 0001437749-23-032239 · rdgdoc.xml · nonDerivative · entry 2

Demopulos Gregory A MD · CIK 0001472160 · Chairman, CEO & President

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse

Disclosed balance after: 108,945

F3 · price: This transaction was executed in multiple trades at prices ranging from $1.43 to $1.45. The price reported above reflects the weighted average sales price.The reporting person hereby undertakes to provide full information regarding the number of shares and prices at which the transactions referenced in thisfootnote were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.

F4 · balance_after: The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, if any, and nothing in this report shall be deemed an admission that the reporting person is the beneficial owner of such securities under Section 16 of the Securities Exchange Act of 1934 or for any other purpose.

SEC source: 0001437749-23-032239 · rdgdoc.xml · nonDerivative · entry 1

Demopulos Gregory A MD · CIK 0001472160 · Chairman, CEO & President

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse

Disclosed balance after: 83,945

F1 · price: This transaction was executed in multiple trades at prices ranging from $1.26 to $1.30. The price reported above reflects the weighted average sales price. The reporting person hereby undertakes to provide full information regarding the number of shares and prices at which the transactions referenced in this footnote were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.

F2 · balance_after: The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, if any, and nothing in this report shall be deemed an admission that the reporting person is the beneficial owner of such securities under Section 16 of the Securities Exchange Act of 1934 or for any other purpose. The shares reported herein include shares held by the reporting person's spouse with respect to which it was previously determined that the reporting person did not have an indirect pecuniary interest.

SEC source: 0001437749-23-026940 · rdgdoc.xml · derivative · entry 1

Cancelmo Peter B · CIK 0001778968 · VP, General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2033-09-22

F1 · derivative.exercise_date: This option shall vest and become exercisable over 48 equal monthly installments, with a vesting commencement date of April 1, 2023. Installments vest and become exercisable on each monthly anniversary thereafter.

SEC source: 0001437749-23-026945 · rdgdoc.xml · derivative · entry 1

Demopulos Gregory A MD · CIK 0001472160 · Chairman, CEO & President

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 715,000

Underlying: Common Stock · 715,000 shares

Expires 2033-09-22

F1 · derivative.exercise_date: This option shall vest and become exercisable over 48 equal monthly installments, with a vesting commencement date of April 1, 2023. Installments vest and become exercisable on each monthly anniversary thereafter.

SEC source: 0001437749-23-026943 · rdgdoc.xml · derivative · entry 1

JACOBSEN MICHAEL A · CIK 0001529087 · VP, Finance & CAO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2033-09-22

F1 · derivative.exercise_date: This option shall vest and become exercisable over 48 equal monthly installments, with a vesting commencement date of April 1, 2023. Installments vest and become exercisable on each monthly anniversary thereafter.

SEC source: 0001437749-23-025925 · rdgdoc.xml · nonDerivative · entry 1

Bumol Thomas F. · CIK 0001767077 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Trust

Disclosed balance after: 10,000

F1 · price: This transaction was executed in multiple trades at prices ranging from $3.31 to $3.36. The price reported above reflects the weighted average sales price. The reporting person hereby undertakes to provide full information regarding the number of shares and prices at which the transactions referenced in this footnote were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.

F2 · ownership.direct: These shares are held of record by a revocable trust, of which the reporting person and his spouse are co-trustees and beneficiaries.

SEC source: 0001415889-23-010358 · form4-06272023_110637.xml · derivative · entry 1

Cable Thomas J. · CIK 0001472158 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2033-06-23

F1 · security: Pursuant to Omeros Corporation's non-employee director compensation policy, on the date of each annual meeting of shareholders, each non-employee director who has served as a director for at least six months and who will continue to serve as a director after the annual meeting is automatically granted an option to purchase 15,000 shares of common stock. This Form 4 reports the annual stock option award granted to the reporting person in conjunction with the annual meeting of shareholders held on June 23, 2023.

F2 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2024 annual meeting of the shareholders of Omeros Corporation, provided that the reporting person continues to serve as a director of the company through such date.

SEC source: 0001415889-23-010376 · form4-06272023_110620.xml · derivative · entry 1

HANISH ARNOLD C · CIK 0001233253 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2033-06-23

F1 · security: Pursuant to Omeros Corporation's non-employee director compensation policy, on the date of each annual meeting of shareholders, each non-employee director who has served as a director for at least six months and who will continue to serve as a director after the annual meeting is automatically granted an option to purchase 15,000 shares of common stock. This Form 4 reports the annual stock option award granted to the reporting person in conjunction with the annual meeting of shareholders held on June 23, 2023.

F2 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2024 annual meeting of the shareholders of Omeros Corporation, provided that the reporting person continues to serve as a director of the company through such date.

SEC source: 0001415889-23-010374 · form4-06272023_110605.xml · derivative · entry 1

Hood Leroy E. MD PhD · CIK 0001472162 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2033-06-23

F1 · security: Pursuant to Omeros Corporation's non-employee director compensation policy, on the date of each annual meeting of shareholders, each non-employee director who has served as a director for at least six months and who will continue to serve as a director after the annual meeting is automatically granted an option to purchase 15,000 shares of common stock. This Form 4 reports the annual stock option award granted to the reporting person in conjunction with the annual meeting of shareholders held on June 23, 2023.

F2 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2024 annual meeting of the shareholders of Omeros Corporation, provided that the reporting person continues to serve as a director of the company through such date.

SEC source: 0001415889-23-010368 · form4-06272023_110636.xml · derivative · entry 1

Demopulos Peter A MD · CIK 0001472161 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2033-06-23

F1 · security: Pursuant to Omeros Corporation's non-employee director compensation policy, on the date of each annual meeting of shareholders, each non-employee director who has served as a director for at least six months and who will continue to serve as a director after the annual meeting is automatically granted an option to purchase 15,000 shares of common stock. This Form 4 reports the annual stock option award granted to the reporting person in conjunction with the annual meeting of shareholders held on June 23, 2023.

F2 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2024 annual meeting of the shareholders of Omeros Corporation, provided that the reporting person continues to serve as a director of the company through such date.

SEC source: 0001415889-23-010364 · form4-06272023_110623.xml · derivative · entry 1

Shah Rajiv · CIK 0001642407 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2033-06-23

F1 · security: Pursuant to Omeros Corporation's non-employee director compensation policy, on the date of each annual meeting of shareholders, each non-employee director who has served as a director for at least six months and who will continue to serve as a director after the annual meeting is automatically granted an option to purchase 15,000 shares of common stock. This Form 4 reports the annual stock option award granted to the reporting person in conjunction with the annual meeting of shareholders held on June 23, 2023.

F2 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2024 annual meeting of the shareholders of Omeros Corporation, provided that the reporting person continues to serve as a director of the company through such date.

SEC source: 0001415889-23-010361 · form4-06272023_110606.xml · derivative · entry 1

Bumol Thomas F. · CIK 0001767077 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2033-06-23

F1 · security: Pursuant to Omeros Corporation's non-employee director compensation policy, on the date of each annual meeting of shareholders, each non-employee director who has served as a director for at least six months and who will continue to serve as a director after the annual meeting is automatically granted an option to purchase 15,000 shares of common stock. This Form 4 reports the annual stock option award granted to the reporting person in conjunction with the annual meeting of shareholders held on June 23, 2023.

F2 · derivative.exercise_date: This option will fully vest and become exercisable on the day before the date of the 2024 annual meeting of the shareholders of Omeros Corporation, provided that the reporting person continues to serve as a director of the company through such date.

SEC source: 0001415889-23-008647 · form4-05232023_090507.xml · derivative · entry 3

Cable Thomas J. · CIK 0001472158 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 5,000 shares

Expires 2023-05-23

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001415889-23-008647 · form4-05232023_090507.xml · nonDerivative · entry 2

Cable Thomas J. · CIK 0001472158 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,067

F1 · price: This transaction was executed in multiple trades at prices ranging from $6.49 to $6.59. The price reported above reflects the weighted average sales price. The reporting person hereby undertakes to provide full information regarding the number of shares and prices at which the transactions referenced in this footnote were effected upon request to the SEC staff, the issuer, or a security holder of the issuer.

SEC source: 0001415889-23-008647 · form4-05232023_090507.xml · nonDerivative · entry 1

Cable Thomas J. · CIK 0001472158 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,067

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.