OBIO

SEC source: 0001104659-25-063692 · tm2519252-4_4seq1.xml · derivative · entry 2

Aryeh Jason · CIK 0001376960 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 36,797

Underlying: Common Stock · 36,797 shares

Expires 2035-06-24

F2 · derivative.exercise_date: The stock options will vest in one installment on the earlier of (x) the one year anniversary of the Grant Date or (y) the date of the Issuer's 2026 Annual Meeting of Stockholders, subject to the Reporting Person's continuous service through such dates.

SEC source: 0001104659-25-063692 · tm2519252-4_4seq1.xml · nonDerivative · entry 1

Aryeh Jason · CIK 0001376960 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 92,482

F1 · shares: Represents an award of restricted stock units ("RSUs") awarded to the Reporting Person on June 24, 2025 (the "Grant Date"). Each RSU represents a contingent right to receive one share of Common Stock. The RSUs will vest in one installment on the earlier of (x) the one year anniversary of the Grant Date or (y) the date of the Issuer's 2026 Annual Meeting of Stockholders, subject to the Reporting Person's continuous service through such dates.

SEC source: 0001104659-25-061170 · tm2518577-1_4seq1.xml · nonDerivative · entry 1

Aiello Joshua · CIK 0001960418 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,329

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units. No shares were sold in the market as a result of the vesting of these restricted stock units and the satisfaction of tax withholding obligations.

SEC source: 0001104659-25-059418 · tm2517997-2_4seq1.xml · nonDerivative · entry 1

Taylor Andrew Lawrence · CIK 0001723889 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 400,788

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units. No shares were sold in the market as a result of the vesting of these restricted stock units and the satisfaction of tax withholding obligations.

SEC source: 0001104659-25-059416 · tm2517997-1_4seq1.xml · nonDerivative · entry 2

Hochman David P · CIK 0001292834 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Indirect · By the DPH 2008 Trust

Disclosed balance after: 329,331

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units. No shares were sold in the market as a result of the vesting of these restricted stock units and the satisfaction of tax withholding obligations.

SEC source: 0001104659-25-059416 · tm2517997-1_4seq1.xml · nonDerivative · entry 1

Hochman David P · CIK 0001292834 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 545,460

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units. No shares were sold in the market as a result of the vesting of these restricted stock units and the satisfaction of tax withholding obligations.

SEC source: 0001104659-25-055019 · tm2516689-1_4seq1.xml · nonDerivative · entry 1

Sherman Darren · CIK 0001723524 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 803,837

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units. No shares were sold in the market as a result of the vesting of these restricted stock units and the satisfaction of tax withholding obligations.

SEC source: 0001062993-25-008272 · form4.xml · nonDerivative · entry 1

RTW INVESTMENTS, LP · CIK 0001493215 · 10% owner

WONG RODERICK · CIK 0001493280 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · Please see footnote

Disclosed balance after: 8,306,063

F1 · ownership.nature: Held by certain affiliated funds managed by RTW Investments, LP ("RTW"). Roderick Wong, M.D. serves as the Managing Partner and Chief Investment Officer of RTW. The reporting persons disclaim beneficial ownership of the reported securities for purposes of Section 16 under the Securities Exchange Act of 1934, as amended, except to the extent of their pecuniary interest therein.

SEC source: 0001062993-25-008205 · form4.xml · nonDerivative · entry 1

RTW INVESTMENTS, LP · CIK 0001493215 · 10% owner

WONG RODERICK · CIK 0001493280 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · Please see footnote

Disclosed balance after: 8,256,163

F1 · ownership.nature: Held by certain affiliated funds managed by RTW Investments, LP ("RTW"). Roderick Wong, M.D. serves as the Managing Partner and Chief Investment Officer of RTW. The reporting persons disclaim beneficial ownership of the reported securities for purposes of Section 16 under the Securities Exchange Act of 1934, as amended, except to the extent of their pecuniary interest therein.

SEC source: 0001104659-25-032332 · tm2511637-4_4seq1.xml · derivative · entry 1

Aiello Joshua · CIK 0001960418 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,000

Underlying: Common Stock · 48,000 shares

Expires 2035-04-03

F1 · derivative.exercise_date: The stock options will vest as follows: (i) 12,000 of the stock options will vest on April 4, 2026 (the "Vesting Commencement Date") and (ii) the remaining 36,000 stock options will vest in equal installments every three months on the same day of the month as the Vesting Commencement Date, starting on July 4, 2026, subject to the Reporting Person's continuous service through such dates.

SEC source: 0001104659-25-032334 · tm2511637-3_4seq1.xml · derivative · entry 7

Hochman David P · CIK 0001292834 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 147,500

Underlying: Common Stock · 147,500 shares

Expires 2035-04-04

F2 · derivative.exercise_date: The stock options will vest as follows: (i) 36,875 of the stock options will vest on April 4, 2026 (the "Vesting Commencement Date") and (ii) the remaining 110,625 stock options will vest in equal installments every three months on the same day of the month as the Vesting Commencement Date, starting on July 4, 2026, subject to the Reporting Person's continuous service through such dates.

SEC source: 0001104659-25-032334 · tm2511637-3_4seq1.xml · nonDerivative · entry 1

Hochman David P · CIK 0001292834 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 579,498

F1 · shares: Represents an award of restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of Common Stock. The RSUs vest over a three-year period as follows: (i) 33.33% of the shares will vest 24 months after April 4, 2025 (the "Issue Date"), (ii) 33.33% of the shares will vest 30 months after the Issue Date, and (iii) 33.34% of the shares will vest 36 months after the Issue Date, subject to the Reporting Person's continuous service through such dates.

SEC source: 0001104659-25-032331 · tm2511637-2_4seq1.xml · nonDerivative · entry 1

Sherman Darren · CIK 0001723524 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 849,680

F1 · shares: Represents an award of restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of Common Stock. The RSUs vest over a three-year period as follows: (i) 33.33% of the shares will vest 24 months after April 4, 2025 (the "Issue Date"), (ii) 33.33% of the shares will vest 30 months after the Issue Date, and (iii) 33.34% of the shares will vest 36 months after the Issue Date, subject to the Reporting Person's continuous service through such dates.

SEC source: 0001104659-25-032330 · tm2511637-1_4seq1.xml · nonDerivative · entry 1

Taylor Andrew Lawrence · CIK 0001723889 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 428,960

F1 · shares: Represents an award of restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of Common Stock. The RSUs vest over a three-year period as follows: (i) 33.33% of the shares will vest 24 months after April 4, 2025 (the "Issue Date"), (ii) 33.33% of the shares will vest 30 months after the Issue Date, and (iii) 33.34% of the shares will vest 36 months after the Issue Date, subject to the Reporting Person's continuous service through such dates.

SEC source: 0001104659-25-029494 · tm2510858-1_4seq1.xml · nonDerivative · entry 1

Aiello Joshua · CIK 0001960418 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,722

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units. No shares were sold in the market as a result of the vesting of these restricted stock units and the satisfaction of tax withholding obligations.

SEC source: 0001104659-25-021856 · tm258652-1_4seq1.xml · nonDerivative · entry 1

Hochman David P · CIK 0001292834 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 499,418

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units. No shares were sold in the market as a result of the vesting of these restricted stock units and the satisfaction of tax withholding obligations.

SEC source: 0001104659-25-009678 · tm255523-2_4seq1.xml · derivative · entry 2

Cleary Chris · CIK 0002054585 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,742

Underlying: Common Stock · 30,742 shares

Expires 2035-02-03

F2 · derivative.exercise_date: The stock options shall vest as follows: (1) 9,223 stock options shall vest on June 24, 2025 and (2) the remaining 21,519 stock options shall vest in three equal, annual installments beginning on February 3, 2026, subject to the Reporting Person's continuous service through such date.

SEC source: 0001104659-25-009678 · tm255523-2_4seq1.xml · nonDerivative · entry 1

Cleary Chris · CIK 0002054585 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,155

F1 · shares: Represents an award of restricted stock units ("RSUs") awarded to the Reporting Person on February 3, 2025. Each RSU represents a contingent right to receive one share of Common Stock. The RSUs vest as follows: (1) 2,987 RSUs vest on June 24, 2025 and (2) the remaining 7,168 RSUs vest in three equal, annual installments beginning on February 3, 2026, subject to the Reporting Person's continuous service through such dates.

SEC source: 0001104659-24-132582 · tm2432271-1_4seq1.xml · derivative · entry 2

Aryeh Jason · CIK 0001376960 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,900

Underlying: Common Stock · 11,700 shares

Expires 2028-11-16

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-24-132582 · tm2432271-1_4seq1.xml · nonDerivative · entry 1

Aryeh Jason · CIK 0001376960 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 80,060

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001104659-24-131767 · tm2431687-2_4seq1.xml · nonDerivative · entry 1

Hochman David P · CIK 0001292834 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 579,498

F1 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $4.60 to $4.75. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001104659-24-130521 · tm2431687-1_4seq1.xml · nonDerivative · entry 1

Taylor Andrew Lawrence · CIK 0001723889 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 344,960

F1 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $4.81 to $4.89. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001104659-24-130007 · tm2431550-1_4seq1.xml · nonDerivative · entry 1

Hochman David P · CIK 0001292834 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 575,498

F1 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $4.88 to $4.94. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001104659-24-128431 · tm2431042-1_4seq1.xml · nonDerivative · entry 1

Taylor Andrew Lawrence · CIK 0001723889 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 343,960

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units.

F1 · shares: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units.

SEC source: 0001104659-24-126333 · tm2430395-1_4seq1.xml · nonDerivative · entry 1

Sherman Darren · CIK 0001723524 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 733,972

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units.

F1 · shares: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units.

SEC source: 0001104659-24-103002 · tm2425000-1_4seq1.xml · nonDerivative · entry 5

Hochman David P · CIK 0001292834 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Indirect · By the Judah Herman Hochman 2019 Trust

Disclosed balance after: 2,000

F5 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $4.72 to $4.77. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the SEC, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001104659-24-103002 · tm2425000-1_4seq1.xml · nonDerivative · entry 4

Hochman David P · CIK 0001292834 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Indirect · By the Hannah Hochman 2019 Trust

Disclosed balance after: 2,000

F4 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $4.68 to $4.77. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the SEC, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001104659-24-103002 · tm2425000-1_4seq1.xml · nonDerivative · entry 3

Hochman David P · CIK 0001292834 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Indirect · By the Solomon Ascher Hochman 2019 Trust

Disclosed balance after: 2,000

F3 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $4.72 to $4.75. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the SEC, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001104659-24-103002 · tm2425000-1_4seq1.xml · nonDerivative · entry 2

Hochman David P · CIK 0001292834 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Indirect · By the DPH 2008 Trust

Disclosed balance after: 335,002

F2 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $4.83 to $4.87, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the SEC, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001104659-24-103002 · tm2425000-1_4seq1.xml · nonDerivative · entry 1

Hochman David P · CIK 0001292834 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 570,498

F1 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $4.90 to $4.95. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission ("SEC"), upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001104659-24-098693 · tm2423769-2_4seq1.xml · nonDerivative · entry 2

Sherman Darren · CIK 0001723524 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 765,787

F1 · shares: The shares reported as disposed herein were granted on July 20, 2023 as restricted stock units ("RSUs"). The disposition of shares is associated with tax obligations of the reporting person associated with the vesting of the RSUs.

F3 · price: The price reported reflects the weighted average sales price. These shares were sold in multiple transactions at prices ranging from $5.13 to $5.69, inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the Issuer or any security holder of the Issuer full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001104659-24-098692 · tm2423769-1_4seq1.xml · nonDerivative · entry 3

Fain Eric S · CIK 0001402222 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By the Fain Living Trust

Disclosed balance after: 41,210

F1 · shares: The shares reported as disposed herein were granted on July 20, 2023 as restricted stock units ("RSUs"). The disposition of shares is associated with tax obligations of the reporting person associated with the vesting of the RSUs.

F4 · price: The price reported reflects the weighted average sales price. These shares were sold in multiple transactions at prices ranging from $5.14 to $5.69, inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the Issuer or any security holder of the Issuer full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001104659-24-098693 · tm2423769-2_4seq1.xml · nonDerivative · entry 1

Sherman Darren · CIK 0001723524 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 772,691

F1 · shares: The shares reported as disposed herein were granted on July 20, 2023 as restricted stock units ("RSUs"). The disposition of shares is associated with tax obligations of the reporting person associated with the vesting of the RSUs.

F2 · price: The price reported reflects the weighted average sales price. These shares were sold in multiple transactions at prices ranging from $5.38 to $5.57, inclusive. The reporting person hereby undertakes to provide upon request to the staff of the Securities and Exchange Commission (the "SEC"), the Issuer or any security holder of the Issuer full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001104659-24-098692 · tm2423769-1_4seq1.xml · nonDerivative · entry 2

Fain Eric S · CIK 0001402222 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By the Fain Living Trust

Disclosed balance after: 43,010

F1 · shares: The shares reported as disposed herein were granted on July 20, 2023 as restricted stock units ("RSUs"). The disposition of shares is associated with tax obligations of the reporting person associated with the vesting of the RSUs.

F3 · price: The price reported reflects the weighted average sales price. These shares were sold in multiple transactions at prices ranging from $5.38 to $5.53, inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the Issuer or any security holder of the Issuer full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001104659-24-097862 · tm2423573-1_4seq1.xml · nonDerivative · entry 3

Sherman Darren · CIK 0001723524 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 779,495

F1 · shares: The shares reported as disposed herein were granted on July 20, 2023 as restricted stock units ("RSUs"). The disposition of shares is associated with tax obligations of the reporting person associated with the vesting of the RSUs.

F4 · price: The price reported reflects the weighted average sales price. These shares were sold in multiple transactions at prices ranging from $5.50 to $5.94, inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the Issuer or any security holder of the Issuer full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001104659-24-098692 · tm2423769-1_4seq1.xml · nonDerivative · entry 1

Fain Eric S · CIK 0001402222 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By the Fain Living Trust

Disclosed balance after: 44,810

F1 · shares: The shares reported as disposed herein were granted on July 20, 2023 as restricted stock units ("RSUs"). The disposition of shares is associated with tax obligations of the reporting person associated with the vesting of the RSUs.

F2 · price: The price reported reflects the weighted average sales price. These shares were sold in multiple transactions at prices ranging from $5.54 to $5.78, inclusive. The reporting person hereby undertakes to provide upon request to the staff of the Securities and Exchange Commission (the "SEC"), the Issuer or any security holder of the Issuer full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001104659-24-097862 · tm2423573-1_4seq1.xml · nonDerivative · entry 2

Sherman Darren · CIK 0001723524 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 786,314

F1 · shares: The shares reported as disposed herein were granted on July 20, 2023 as restricted stock units ("RSUs"). The disposition of shares is associated with tax obligations of the reporting person associated with the vesting of the RSUs.

F3 · price: The price reported reflects the weighted average sales price. These shares were sold in multiple transactions at prices ranging from $5.61 to $6.14, inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the Issuer or any security holder of the Issuer full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001104659-24-097862 · tm2423573-1_4seq1.xml · nonDerivative · entry 1

Sherman Darren · CIK 0001723524 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 793,275

F1 · shares: The shares reported as disposed herein were granted on July 20, 2023 as restricted stock units ("RSUs"). The disposition of shares is associated with tax obligations of the reporting person associated with the vesting of the RSUs.

F2 · price: The price reported reflects the weighted average sales price. These shares were sold in multiple transactions at prices ranging from $6.00 to $6.19, inclusive. The reporting person hereby undertakes to provide upon request to the staff of the Securities and Exchange Commission (the "SEC"), the Issuer or any security holder of the Issuer full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001104659-24-090181 · tm2421778-1_4seq1.xml · nonDerivative · entry 1

Hochman David P · CIK 0001292834 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 567,998

SEC source: 0001104659-24-087387 · tm2421267-1_4seq1.xml · derivative · entry 2

Mack John Prosper · CIK 0002031699 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 40,737

Underlying: Common Stock · 40,737 shares

Expires 2034-08-07

F2 · derivative.exercise_date: The stock options shall vest as follows: (1) 19,218 stock options shall vest on June 20, 2025 and (2) the remaining 21,519 stock options shall vest in three equal, annual installments beginning on August 7, 2025, subject to the Reporting Person's continuous service through such date.

SEC source: 0001104659-24-087387 · tm2421267-1_4seq1.xml · nonDerivative · entry 1

Mack John Prosper · CIK 0002031699 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,864

F1 · shares: Represents an award of restricted stock units ("RSUs") awarded to the Reporting Person on August 7, 2024. Each RSU represents a contingent right to receive one share of Common Stock. The RSUs vest as follows: (1) 6,003 RSUs vest on June 20, 2025 and (2) the remaining 6,861 RSUs vest in three equal, annual installments beginning on August 7, 2025, subject to the Reporting Person's continuous service through such dates.

SEC source: 0001062993-24-014634 · form4.xml · nonDerivative · entry 1

HSAC 2 Holdings, LLC · CIK 0001814116 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,705,705

F1 · kind: The Reporting Person distributed the shares pro-rata to certain of its members.

SEC source: 0001104659-24-075169 · tm2418333-1_4seq1.xml · nonDerivative · entry 1

Hochman David P · CIK 0001292834 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Indirect · By the DPH 2008 Trust

Disclosed balance after: 333,502

SEC source: 0001104659-24-074011 · tm2417742-3_4seq1.xml · derivative · entry 2

ROSE ERIC A MD · CIK 0001139301 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,068

Underlying: Common Stock · 17,068 shares

Expires 2034-06-20

SEC source: 0001104659-24-074011 · tm2417742-3_4seq1.xml · nonDerivative · entry 1

ROSE ERIC A MD · CIK 0001139301 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,544

F1 · shares: Represents an award of restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of Common Stock. The RSUs vest on June 20, 2025.

SEC source: 0001104659-24-074013 · tm2417742-5_4seq1.xml · derivative · entry 2

Connealy Pamela Ann · CIK 0001796310 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,068

Underlying: Common Stock · 17,068 shares

Expires 2034-06-20

SEC source: 0001104659-24-074013 · tm2417742-5_4seq1.xml · nonDerivative · entry 1

Connealy Pamela Ann · CIK 0001796310 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,289

F1 · shares: Represents an award of restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of Common Stock. The RSUs vest on June 20, 2025.

SEC source: 0001104659-24-074012 · tm2417742-4_4seq1.xml · derivative · entry 2

Aryeh Jason · CIK 0001376960 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,068

Underlying: Common Stock · 17,068 shares

Expires 2034-06-20

SEC source: 0001104659-24-074012 · tm2417742-4_4seq1.xml · nonDerivative · entry 1

Aryeh Jason · CIK 0001376960 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 68,360

F1 · shares: Represents an award of restricted stock units ("RSUs") awarded to the Reporting Person on June 20, 2024. Each RSU represents a contingent right to receive one share of Common Stock. The RSUs vest on June 20, 2025.

SEC source: 0001104659-24-074010 · tm2417742-2_4seq1.xml · derivative · entry 2

Fain Eric S · CIK 0001402222 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By the Fain Living Trust

Disclosed balance after: 17,068

Underlying: Common Stock · 17,068 shares

Expires 2034-06-20