OBIO

SEC source: 0001104659-26-113320 · tm2626947-1_4seq1.xml · nonDerivative · entry 1

Sherman Darren · CIK 0001723524 · Director · See Remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,119,402

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 18, 2025.

F2 · price: The price reported is a weighted average price. These shares were disposed in multiple transactions at prices ranging from $6.20 to $6.48. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares disposed at each separate price within the range set forth in this footnote.

SEC source: 0001104659-26-107143 · tm2625275-1_4seq1.xml · nonDerivative · entry 2

Hochman David P · CIK 0001292834 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Indirect · By the DPH 2008 Trust

Disclosed balance after: 432,916

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units ("RSUs"). No shares were sold in the market as a result of the vesting of these RSUs and the satisfaction of tax withholding obligations.

SEC source: 0001104659-26-107143 · tm2625275-1_4seq1.xml · nonDerivative · entry 1

Hochman David P · CIK 0001292834 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,067,463

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units ("RSUs"). No shares were sold in the market as a result of the vesting of these RSUs and the satisfaction of tax withholding obligations.

SEC source: 0001104659-26-105690 · tm2624891-1_4seq1.xml · nonDerivative · entry 1

Hochman David P · CIK 0001292834 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,070,746

F1 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $4.73 to $4.79. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001104659-26-104739 · tm2624698-1_4seq1.xml · nonDerivative · entry 1

Sherman Darren · CIK 0001723524 · Director · See Remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,134,402

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 18, 2025.

F2 · price: The price reported is a weighted average price. These shares were disposed in multiple transactions at prices ranging from $4.88 to $5.06. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares disposed at each separate price within the range set forth in this footnote.

SEC source: 0001104659-26-103210 · tm2624220-3_4seq1.xml · nonDerivative · entry 1

Taylor Andrew Lawrence · CIK 0001723889 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 589,989

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units ("RSUs"). No shares were sold in the market as a result of the vesting of these RSUs and the satisfaction of tax withholding obligations.

SEC source: 0001104659-26-103209 · tm2624220-2_4seq1.xml · nonDerivative · entry 2

Sherman Darren · CIK 0001723524 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Indirect · By son

Disclosed balance after: 2,000

F2 · shares: The reporting person disclaims beneficial ownership of these securities, and this report shall not be deemed an admission that the reporting person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose.

F2 · balance_after: The reporting person disclaims beneficial ownership of these securities, and this report shall not be deemed an admission that the reporting person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose.

SEC source: 0001104659-26-103209 · tm2624220-2_4seq1.xml · nonDerivative · entry 1

Sherman Darren · CIK 0001723524 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,149,402

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units ("RSUs"). No shares were sold in the market as a result of the vesting of these RSUs and the satisfaction of tax withholding obligations.

SEC source: 0001104659-26-103205 · tm2624220-1_4seq1.xml · nonDerivative · entry 1

Aiello Joshua · CIK 0001960418 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,441

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units ("RSUs"). No shares were sold in the market as a result of the vesting of these RSUs and the satisfaction of tax withholding obligations.

SEC source: 0001104659-26-097174 · tm2623285-1_4seq1.xml · nonDerivative · entry 1

Cleary Chris · CIK 0002054585 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,153

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units ("RSUs"). No shares were sold in the market as a result of the vesting of these RSUs and the satisfaction of tax withholding obligations.

SEC source: 0001104659-26-097183 · tm2623285-2_4seq1.xml · nonDerivative · entry 1

Mack John Prosper · CIK 0002031699 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 66,544

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units ("RSUs"). No shares were sold in the market as a result of the vesting of these RSUs and the satisfaction of tax withholding obligations.

SEC source: 0001104659-26-097195 · tm2623285-4_4seq1.xml · nonDerivative · entry 1

Pacitti David · CIK 0001722733 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 54,750

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units ("RSUs"). No shares were sold in the market as a result of the vesting of these RSUs and the satisfaction of tax withholding obligations.

SEC source: 0001104659-26-097192 · tm2623285-3_4seq1.xml · nonDerivative · entry 1

Fain Eric S · CIK 0001402222 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By the Fain Living Trust

Disclosed balance after: 99,630

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units ("RSUs"). No shares were sold in the market as a result of the vesting of these RSUs and the satisfaction of tax withholding obligations.

SEC source: 0001104659-26-090449 · tm2622228-1_4seq1.xml · nonDerivative · entry 1

Sherman Darren · CIK 0001723524 · Director · See Remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,154,327

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 18, 2025.

F2 · price: The price reported is a weighted average price. These shares were disposed in multiple transactions at prices ranging from $3.94 to $4.15. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares disposed at each separate price within the range set forth in this footnote.

SEC source: 0001104659-26-080333 · tm2619667-1_4seq1.xml · nonDerivative · entry 1

Sherman Darren · CIK 0001723524 · Director · See Remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,169,327

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 18, 2025.

F2 · price: The price reported is a weighted average price. These shares were disposed in multiple transactions at prices ranging from $4.21 to $4.32. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares disposed at each separate price within the range set forth in this footnote.

SEC source: 0001104659-26-077777 · tm2618965-4_4seq1.xml · nonDerivative · entry 1

Cleary Chris · CIK 0002054585 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,391

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units ("RSUs"). No shares were sold in the market as a result of the vesting of these RSUs and the satisfaction of tax withholding obligations.

SEC source: 0001104659-26-077767 · tm2618965-1_4seq1.xml · nonDerivative · entry 2

Mack John Prosper · CIK 0002031699 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 71,429

F2 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of RSUs. No shares were sold in the market as a result of the vesting of these RSUs and the satisfaction of tax withholding obligations.

SEC source: 0001104659-26-077780 · tm2618965-6_4seq1.xml · nonDerivative · entry 2

Fain Eric S · CIK 0001402222 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By the Fain Living Trust

Disclosed balance after: 104,775

F2 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of RSUs. No shares were sold in the market as a result of the vesting of these RSUs and the satisfaction of tax withholding obligations.

SEC source: 0001104659-26-077778 · tm2618965-5_4seq1.xml · nonDerivative · entry 2

Pacitti David · CIK 0001722733 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 58,511

F2 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of RSUs. No shares were sold in the market as a result of the vesting of these RSUs and the satisfaction of tax withholding obligations.

SEC source: 0001104659-26-077777 · tm2618965-4_4seq1.xml · derivative · entry 2

Cleary Chris · CIK 0002054585 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,553

Underlying: Common Stock · 42,553 shares

Expires 2036-06-23

F2 · derivative.exercise_date: The stock options will vest on the one year anniversary of June 23rd, 2026 (the "Grant Date"), subject to the Reporting Person's continuous service through such date.

SEC source: 0001104659-26-077767 · tm2618965-1_4seq1.xml · nonDerivative · entry 1

Mack John Prosper · CIK 0002031699 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 74,939

F1 · shares: Represents an award of restricted stock units ("RSUs") awarded to the Reporting Person on June 23, 2026 (the "Grant Date"). Each RSU represents a contingent right to receive one share of Common Stock. The RSUs will vest on the one year anniversary of the Grant Date, subject to the Reporting Person's continuous service through such date.

SEC source: 0001104659-26-077780 · tm2618965-6_4seq1.xml · derivative · entry 3

Fain Eric S · CIK 0001402222 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By the Fain Living Trust

Disclosed balance after: 21,277

Underlying: Common Stock · 21,277 shares

Expires 2036-06-23

F3 · derivative.exercise_date: The stock options will vest on the one year anniversary of the Grant Date, subject to the Reporting Person's continuous service through such date.

SEC source: 0001104659-26-077780 · tm2618965-6_4seq1.xml · nonDerivative · entry 1

Fain Eric S · CIK 0001402222 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By the Fain Living Trust

Disclosed balance after: 109,036

F1 · shares: Represents an award of restricted stock units ("RSUs") awarded to the Reporting Person on June 23, 2026 (the "Grant Date"). Each RSU represents a contingent right to receive one share of Common Stock. The RSUs will vest on the one year anniversary of the Grant Date, subject to the Reporting Person's continuous service through such date.

SEC source: 0001104659-26-077778 · tm2618965-5_4seq1.xml · derivative · entry 3

Pacitti David · CIK 0001722733 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,277

Underlying: Common Stock · 21,277 shares

Expires 2036-06-23

F3 · derivative.exercise_date: The stock options will vest on the one year anniversary of the Grant Date, subject to the Reporting Person's continuous service through such date.

SEC source: 0001104659-26-077778 · tm2618965-5_4seq1.xml · nonDerivative · entry 1

Pacitti David · CIK 0001722733 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 62,295

F1 · shares: Represents an award of restricted stock units ("RSUs") awarded to the Reporting Person on June 23, 2026 (the "Grant Date"). Each RSU represents a contingent right to receive one share of Common Stock. The RSUs will vest on the one year anniversary of the Grant Date, subject to the Reporting Person's continuous service through such date.

SEC source: 0001104659-26-077775 · tm2618965-3_4seq1.xml · derivative · entry 2

Connealy Pamela Ann · CIK 0001796310 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,277

Underlying: Common Stock · 21,277 shares

Expires 2036-06-23

F2 · derivative.exercise_date: The stock options will vest on the one year anniversary of the Grant Date, subject to the Reporting Person's continuous service through such date.

SEC source: 0001104659-26-077775 · tm2618965-3_4seq1.xml · nonDerivative · entry 1

Connealy Pamela Ann · CIK 0001796310 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 66,038

F1 · shares: Represents an award of restricted stock units ("RSUs") awarded to the Reporting Person on June 23, 2026 (the "Grant Date"). Each RSU represents a contingent right to receive one share of Common Stock. The RSUs will vest on the one year anniversary of the Grant Date, subject to the Reporting Person's continuous service through such date.

SEC source: 0001104659-26-077771 · tm2618965-2_4seq1.xml · derivative · entry 1

Aryeh Jason · CIK 0001376960 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 42,553

Underlying: Common Stock · 42,553 shares

Expires 2036-06-23

F1 · derivative.exercise_date: The stock options will vest on the one year anniversary of June 23rd, 2026 (the "Grant Date"), subject to the Reporting Person's continuous service through such date.

SEC source: 0001104659-26-073476 · tm2617747-2_4seq1.xml · nonDerivative · entry 1

Taylor Andrew Lawrence · CIK 0001723889 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 593,065

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units ("RSUs"). No shares were sold in the market as a result of the vesting of these RSUs and the satisfaction of tax withholding obligations.

SEC source: 0001104659-26-073468 · tm2617747-1_4seq1.xml · nonDerivative · entry 2

Hochman David P · CIK 0001292834 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Indirect · By the DPH 2008 Trust

Disclosed balance after: 436,199

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units ("RSUs"). No shares were sold in the market as a result of the vesting of these RSUs and the satisfaction of tax withholding obligations.

SEC source: 0001104659-26-073468 · tm2617747-1_4seq1.xml · nonDerivative · entry 1

Hochman David P · CIK 0001292834 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,060,746

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units ("RSUs"). No shares were sold in the market as a result of the vesting of these RSUs and the satisfaction of tax withholding obligations.

SEC source: 0001104659-26-069510 · tm2616712-2_4seq1.xml · nonDerivative · entry 1

Hochman David P · CIK 0001292834 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,064,029

F1 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $3.80 to $3.91. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001104659-26-069503 · tm2616712-1_4seq1.xml · nonDerivative · entry 1

Sherman Darren · CIK 0001723524 · Director · See Remarks

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,184,327

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 18, 2025.

F2 · price: The price reported is a weighted average price. These shares were disposed in multiple transactions at prices ranging from $3.81 to $4.01. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares disposed at each separate price within the range set forth in this footnote.

SEC source: 0001104659-26-068278 · tm2616050-2_4seq1.xml · nonDerivative · entry 1

Taylor Andrew Lawrence · CIK 0001723889 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 629,417

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units ("RSUs"). No shares were sold in the market as a result of the vesting of these RSUs and the satisfaction of tax withholding obligations.

SEC source: 0001104659-26-068274 · tm2616050-1_4seq1.xml · nonDerivative · entry 1

Sherman Darren · CIK 0001723524 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,199,327

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units ("RSUs"). No shares were sold in the market as a result of the vesting of these RSUs and the satisfaction of tax withholding obligations.

SEC source: 0001104659-26-064136 · tm2615140-1_4seq1.xml · nonDerivative · entry 1

Aryeh Jason · CIK 0001376960 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 118,118

F1 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $3.75 to $3.76. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001104659-26-063511 · tm2614983-1_4seq1.xml · nonDerivative · entry 1

Aryeh Jason · CIK 0001376960 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 117,453

F1 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $3.70 to $4.03. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001104659-26-063510 · tm2614983-2_4seq1.xml · nonDerivative · entry 1

Hochman David P · CIK 0001292834 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,059,029

F1 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $3.75 to $3.79. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001104659-26-063015 · tm2614903-1_4seq1.xml · nonDerivative · entry 1

Fain Eric S · CIK 0001402222 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By the Fain Living Trust

Disclosed balance after: 91,709

F1 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $4.10 to $4.14. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001231919-26-000427 · form4-04292026_090438.xml · derivative · entry 3

RTW INVESTMENTS, LP · CIK 0001493215 · 10% owner

WONG RODERICK · CIK 0001493280 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 2,386,331

Underlying: Common Stock · 1,250,032 shares

Expires not disclosed

F1 · kind: On April 27, 2026, the RTW Funds exercised Pre-Funded Warrants to purchase an aggregate of 1,250,032 shares of the Issuer's common stock for $0.0001 a share. The RTW Funds exercised the Pre-Funded Warrants on a cashless basis, resulting in the Issuer's withholding 32 of such shares to satisfy the exercise price of the Pre-Funded Warrants, and the issuance to the RTW Funds of an aggregate of 1,250,000 shares.

F3 · derivative.exercise_date: The Pre-Funded Warrants have no expiration date and are exercisable immediately. Notwithstanding the foregoing, the RTW Funds shall not be entitled to exercise the Pre-Funded Warrants to the extent that it would cause the aggregate number of shares of Common Stock beneficially owned by the RTW Funds, together with their Attribution Parties (as defined in the Pre-Funded Warrants), to exceed 19.99% of the total number of issued and outstanding shares of Common Stock of the Issuer following such exercise.

F3 · derivative.expiration_date: The Pre-Funded Warrants have no expiration date and are exercisable immediately. Notwithstanding the foregoing, the RTW Funds shall not be entitled to exercise the Pre-Funded Warrants to the extent that it would cause the aggregate number of shares of Common Stock beneficially owned by the RTW Funds, together with their Attribution Parties (as defined in the Pre-Funded Warrants), to exceed 19.99% of the total number of issued and outstanding shares of Common Stock of the Issuer following such exercise.

F2 · ownership.nature: Held by certain affiliated funds (the "RTW Funds") managed by RTW Investments, LP ("RTW"). Roderick Wong, M.D. serves as the Managing Partner and Chief Investment Officer of RTW. The Reporting Persons disclaim beneficial ownership of the reported securities for purposes of Section 16 under the Securities Exchange Act of 1934, as amended, except to the extent of their pecuniary interest therein.

SEC source: 0001231919-26-000427 · form4-04292026_090438.xml · nonDerivative · entry 2

RTW INVESTMENTS, LP · CIK 0001493215 · 10% owner

WONG RODERICK · CIK 0001493280 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 9,556,063

F1 · kind: On April 27, 2026, the RTW Funds exercised Pre-Funded Warrants to purchase an aggregate of 1,250,032 shares of the Issuer's common stock for $0.0001 a share. The RTW Funds exercised the Pre-Funded Warrants on a cashless basis, resulting in the Issuer's withholding 32 of such shares to satisfy the exercise price of the Pre-Funded Warrants, and the issuance to the RTW Funds of an aggregate of 1,250,000 shares.

F2 · ownership.nature: Held by certain affiliated funds (the "RTW Funds") managed by RTW Investments, LP ("RTW"). Roderick Wong, M.D. serves as the Managing Partner and Chief Investment Officer of RTW. The Reporting Persons disclaim beneficial ownership of the reported securities for purposes of Section 16 under the Securities Exchange Act of 1934, as amended, except to the extent of their pecuniary interest therein.

SEC source: 0001231919-26-000427 · form4-04292026_090438.xml · nonDerivative · entry 1

RTW INVESTMENTS, LP · CIK 0001493215 · 10% owner

WONG RODERICK · CIK 0001493280 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 9,556,095

F1 · kind: On April 27, 2026, the RTW Funds exercised Pre-Funded Warrants to purchase an aggregate of 1,250,032 shares of the Issuer's common stock for $0.0001 a share. The RTW Funds exercised the Pre-Funded Warrants on a cashless basis, resulting in the Issuer's withholding 32 of such shares to satisfy the exercise price of the Pre-Funded Warrants, and the issuance to the RTW Funds of an aggregate of 1,250,000 shares.

F2 · ownership.nature: Held by certain affiliated funds (the "RTW Funds") managed by RTW Investments, LP ("RTW"). Roderick Wong, M.D. serves as the Managing Partner and Chief Investment Officer of RTW. The Reporting Persons disclaim beneficial ownership of the reported securities for purposes of Section 16 under the Securities Exchange Act of 1934, as amended, except to the extent of their pecuniary interest therein.

SEC source: 0001104659-26-036168 · tm269936-3_4seq1.xml · nonDerivative · entry 1

Sherman Darren · CIK 0001723524 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,204,252

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units ("RSUs"). No shares were sold in the market as a result of the vesting of these RSUs and the satisfaction of tax withholding obligations.

SEC source: 0001104659-26-036167 · tm269936-2_4seq1.xml · nonDerivative · entry 1

Aiello Joshua · CIK 0001960418 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,644

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units ("RSUs"). No shares were sold in the market as a result of the vesting of these RSUs and the satisfaction of tax withholding obligations.

SEC source: 0001104659-26-036162 · tm269936-1_4seq1.xml · nonDerivative · entry 1

Hochman David P · CIK 0001292834 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,054,029

F1 · kind: Represents the withholding of shares by the Issuer to satisfy tax withholding obligations in connection with vesting of restricted stock units ("RSUs"). No shares were sold in the market as a result of the vesting of these RSUs and the satisfaction of tax withholding obligations.

SEC source: 0001104659-26-028554 · tm268956-1_4seq1.xml · nonDerivative · entry 1

Hochman David P · CIK 0001292834 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,086,467

F1 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $4.28 to $4.30. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001104659-26-015325 · tm266316-4_4seq1.xml · derivative · entry 1

Aiello Joshua · CIK 0001960418 · Principal Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 70,000

Underlying: Common Stock · 70,000 shares

Expires 2036-02-12

F1 · derivative.exercise_date: The stock options will vest as follows: (i) 25% of the stock options will vest on February 12, 2027 (the "Vesting Commencement Date") and (ii) the remaining 75% stock options will vest in equal installments every three months on the same day of the month as the Vesting Commencement Date, starting on May 12, 2027, subject to the Reporting Person's continuous service through such dates.

SEC source: 0001104659-26-015323 · tm266316-3_4seq1.xml · nonDerivative · entry 1

Sherman Darren · CIK 0001723524 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,237,569

F1 · shares: Represents an award of restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of Common Stock. The RSUs vest over a three-year period as follows: (i) 25% of the shares will vest 18 months after February 12, 2026 (the "Issue Date"), (ii) 25% of the shares will vest 24 months after the Issue Date, (iii) 25% of the shares will vest 30 months after the Issue Date and (iv) 25% of the shares will vest 36 months after the Issue Date, subject to the Reporting Person's continuous service through such dates.

SEC source: 0001104659-26-015318 · tm266316-1_4seq1.xml · nonDerivative · entry 1

Hochman David P · CIK 0001292834 · Director · See Remarks

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,076,467

F1 · shares: Represents an award of restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of Common Stock. The RSUs vest over a three-year period as follows: (i) 25% of the shares will vest 18 months after February 12, 2026 (the "Issue Date"), (ii) 25% of the shares will vest 24 months after the Issue Date, (iii) 25% of the shares will vest 30 months after the Issue Date and (iv) 25% of the shares will vest 36 months after the Issue Date, subject to the Reporting Person's continuous service through such dates.

SEC source: 0001104659-26-015320 · tm266316-2_4seq1.xml · nonDerivative · entry 1

Taylor Andrew Lawrence · CIK 0001723889 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 632,493

F1 · shares: Represents an award of restricted stock units ("RSUs"). Each RSU represents a contingent right to receive one share of Common Stock. The RSUs vest over a three-year period as follows: (i) 25% of the shares will vest 18 months after February 12, 2026 (the "Issue Date"), (ii) 25% of the shares will vest 24 months after the Issue Date, (iii) 25% of the shares will vest 30 months after the Issue Date and (iv) 25% of the shares will vest 36 months after the Issue Date, subject to the Reporting Person's continuous service through such dates.