NKTX

SEC source: 0000899243-22-028291 · doc4.xml · nonDerivative · entry 1

Brandenberger Ralph · CIK 0001853197 · Chief Technical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,167

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person at least 30 days prior to the trade date.

SEC source: 0000899243-22-028290 · doc4.xml · derivative · entry 3

Mahmood Nadir · CIK 0001816598 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,522

Underlying: Common Stock · 7,500 shares

Expires 2029-09-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person at least 30 days prior to the trade date.

F3 · derivative.exercise_date: The options exercised were fully vested. Unvested options will vest and become exercisable ratably in monthly installments until fully vested on September 5, 2023.

SEC source: 0000899243-22-028290 · doc4.xml · nonDerivative · entry 2

Mahmood Nadir · CIK 0001816598 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,088

F1 · kind: The transactions reported in this Form 4 were effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person at least 30 days prior to the trade date.

F2 · price: This transaction was executed in multiple trades at prices ranging from $15.00 to $15.85. The price reported above reflects the weighted average price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000899243-22-028290 · doc4.xml · nonDerivative · entry 1

Mahmood Nadir · CIK 0001816598 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,588

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person at least 30 days prior to the trade date.

SEC source: 0000899243-22-026768 · doc4.xml · derivative · entry 3

Brandenberger Ralph · CIK 0001853197 · Chief Technical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,367

Underlying: Common Stock · 3,000 shares

Expires 2028-07-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person at least 30 days prior to the trade date.

F3 · derivative.exercise_date: This stock option is fully vested.

SEC source: 0000899243-22-026768 · doc4.xml · nonDerivative · entry 2

Brandenberger Ralph · CIK 0001853197 · Chief Technical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,800

F1 · kind: The transactions reported in this Form 4 were effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person at least 30 days prior to the trade date.

F2 · price: This transaction was executed in multiple trades at prices ranging from $13.29 to $13.59. The price reported above reflects the weighted average price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000899243-22-026768 · doc4.xml · nonDerivative · entry 1

Brandenberger Ralph · CIK 0001853197 · Chief Technical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,800

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person at least 30 days prior to the trade date.

SEC source: 0000899243-22-026767 · doc4.xml · derivative · entry 3

Mahmood Nadir · CIK 0001816598 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 63,243

Underlying: Common Stock · 7,500 shares

Expires 2029-09-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person at least 30 days prior to the trade date.

F3 · derivative.exercise_date: The options exercised were fully vested. Unvested options will vest and become exercisable ratably in monthly installments until fully vested on September 5, 2023.

SEC source: 0000899243-22-026767 · doc4.xml · nonDerivative · entry 2

Mahmood Nadir · CIK 0001816598 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,088

F1 · kind: The transactions reported in this Form 4 were effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person at least 30 days prior to the trade date.

F2 · price: This transaction was executed in multiple trades at prices ranging from $13.26 to $13.57. The price reported above reflects the weighted average price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0000899243-22-026767 · doc4.xml · nonDerivative · entry 1

Mahmood Nadir · CIK 0001816598 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,588

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person at least 30 days prior to the trade date.

SEC source: 0000899243-22-026252 · doc4.xml · derivative · entry 1

Brandenberger Ralph · CIK 0001853197 · Chief Technical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2032-07-14

F1 · derivative.exercise_date: This option is scheduled to vest and become exercisable in 48 equal monthly installments occurring on the completion of each successive month of the Reporting Person's service to the Issuer following the grant date.

SEC source: 0001209191-22-038523 · doc4.xml · derivative · entry 2

Brandenberger Ralph · CIK 0001853197 · Sr. VP, Technical Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires 2032-06-16

F2 · derivative.exercise_date: This option is scheduled to vest and become exercisable in 48 equal monthly installments occurring on the completion of each successive month of the Reporting Person's service to the Issuer following June 17, 2022.

SEC source: 0001209191-22-038523 · doc4.xml · nonDerivative · entry 1

Brandenberger Ralph · CIK 0001853197 · Sr. VP, Technical Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,800

F1 · shares: Represents Restricted Stock Units ("RSUs") which vest in four equal annual installments beginning on the first anniversary of the grant date. Each RSU represents a contingent right to receive one share of Common Stock of the Issuer.

SEC source: 0001209191-22-038530 · doc4.xml · derivative · entry 2

Mahmood Nadir · CIK 0001816598 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2032-06-16

F2 · derivative.exercise_date: This option is scheduled to vest and become exercisable in 48 equal monthly installments occurring on the completion of each successive month of the Reporting Person's service to the Issuer following June 17, 2022.

SEC source: 0001209191-22-038530 · doc4.xml · nonDerivative · entry 1

Mahmood Nadir · CIK 0001816598 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,088

F1 · shares: Represents Restricted Stock Units ("RSUs") which vest in four equal annual installments beginning on the first anniversary of the grant date. Each RSU represents a contingent right to receive one share of Common Stock of the Issuer.

SEC source: 0001209191-22-038525 · doc4.xml · derivative · entry 2

Trager James · CIK 0001816549 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2032-06-16

F2 · derivative.exercise_date: This option is scheduled to vest and become exercisable in 48 equal monthly installments occurring on the completion of each successive month of the Reporting Person's service to the Issuer following June 17, 2022.

SEC source: 0001209191-22-038525 · doc4.xml · nonDerivative · entry 1

Trager James · CIK 0001816549 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 62,172

F1 · shares: Represents Restricted Stock Units ("RSUs") which vest in four equal annual installments beginning on the first anniversary of the grant date. Each RSU represents a contingent right to receive one share of Common Stock of the Issuer.

SEC source: 0001209191-22-038532 · doc4.xml · derivative · entry 2

HASTINGS PAUL J · CIK 0001309702 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 120,000

Underlying: Common Stock · 120,000 shares

Expires 2032-06-16

F2 · derivative.exercise_date: This option is scheduled to vest and become exercisable in 48 equal monthly installments occurring on the completion of each successive month of the Reporting Person's service to the Issuer following June 17, 2022.

SEC source: 0001209191-22-038532 · doc4.xml · nonDerivative · entry 1

HASTINGS PAUL J · CIK 0001309702 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 280,461

F1 · shares: Represents Restricted Stock Units ("RSUs") which vest in four equal annual installments beginning on the first anniversary of the grant date. Each RSU represents a contingent right to receive one share of Common Stock of the Issuer.

SEC source: 0001209191-22-038528 · doc4.xml · derivative · entry 2

Hager Alicia J. · CIK 0001553354 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 50,500

Underlying: Common Stock · 50,500 shares

Expires 2032-06-16

F2 · derivative.exercise_date: This option is scheduled to vest and become exercisable in 48 equal monthly installments occurring on the completion of each successive month of the Reporting Person's service to the Issuer following June 17, 2022.

SEC source: 0001209191-22-038528 · doc4.xml · nonDerivative · entry 1

Hager Alicia J. · CIK 0001553354 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,800

F1 · shares: Represents Restricted Stock Units ("RSUs") which vest in four equal annual installments beginning on the first anniversary of the grant date. Each RSU represents a contingent right to receive one share of Common Stock of the Issuer.

SEC source: 0001209191-22-035814 · doc4.xml · derivative · entry 1

Azzam Fouad Oscar · CIK 0001816531 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,000

Underlying: Common Stock · 16,000 shares

Expires 2032-06-07

F1 · derivative.exercise_date: All shares subject to the option vest 100% on the first to occur of (i) June 8, 2023 or (ii) the day immediately preceding the first annual meeting of the Issuer's stockholders to occur after the date of grant of the award. Each grant, to the extent outstanding and otherwise unvested, will become fully vested should a "change in control" of the Issuer occur (as described in the applicable award agreement) or upon the Reporting Person's separation from service with the Issuer due to the Reporting Person's death or "disability" (as described in the applicable award agreement).

SEC source: 0001209191-22-035834 · doc4.xml · derivative · entry 1

Scheiner Zachary · CIK 0001816523 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,000

Underlying: Common Stock · 16,000 shares

Expires 2032-06-07

F1 · derivative.exercise_date: All shares subject to the option vest 100% on the first to occur of (i) June 8, 2023 or (ii) the day immediately preceding the first annual meeting of the Issuer's stockholders to occur after the date of grant of the award. Each grant, to the extent outstanding and otherwise unvested, will become fully vested should a "change in control" of the Issuer occur (as described in the applicable award agreement) or upon the Reporting Person's separation from service with the Issuer due to the Reporting Person's death or "disability" (as described in the applicable award agreement).

F2 · ownership.direct: Under the Reporting Person's arrangement with RA Capital Management, L.P. (the "Adviser"), the Reporting Person holds the stock option for the benefit of the RA Capital Healthcare Fund, L.P. (the "Fund") and the RA Capital Nexus Fund, L.P. (the "Nexus Fund"). The Reporting Person is obligated to turn over to the Adviser any net cash or stock received upon exercise of the stock option, which will offset advisory fees owed by the Fund and the Nexus Fund. The Reporting Person therefore disclaims beneficial ownership of the stock option and underlying common stock.

SEC source: 0001209191-22-035849 · doc4.xml · derivative · entry 1

Thedinga Angela · CIK 0001804588 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,218

Underlying: Common Stock · 3,218 shares

Expires 2032-06-07

F1 · derivative.exercise_date: All shares subject to the option vest 100% on the first to occur of (i) June 8, 2023 or (ii) the day immediately preceding the first annual meeting of the Issuer's stockholders to occur after the date of grant of the award. Each grant, to the extent outstanding and otherwise unvested, will become fully vested should a "change in control" of the Issuer occur (as described in the applicable award agreement) or upon the Reporting Person's separation from service with the Issuer due to the Reporting Person's death or "disability" (as described in the applicable award agreement).

SEC source: 0001209191-22-035808 · doc4.xml · derivative · entry 1

Aynechi Tiba · CIK 0001669220 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,000

Underlying: Common Stock · 16,000 shares

Expires 2032-06-07

F1 · derivative.exercise_date: All shares subject to the option vest 100% on the first to occur of (i) June 8, 2023 or (ii) the day immediately preceding the first annual meeting of the Issuer's stockholders to occur after the date of grant of the award. Each grant, to the extent outstanding and otherwise unvested, will become fully vested should a "change in control" of the Issuer occur (as described in the applicable award agreement) or upon the Reporting Person's separation from service with the Issuer due to the Reporting Person's death or "disability" (as described in the applicable award agreement).

SEC source: 0001209191-22-035828 · doc4.xml · derivative · entry 1

PATTERSON LEONE D · CIK 0001233539 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,000

Underlying: Common Stock · 16,000 shares

Expires 2032-06-07

F1 · derivative.exercise_date: All shares subject to the option vest 100% on the first to occur of (i) June 8, 2023 or (ii) the day immediately preceding the first annual meeting of the Issuer's stockholders to occur after the date of grant of the award. Each grant, to the extent outstanding and otherwise unvested, will become fully vested should a "change in control" of the Issuer occur (as described in the applicable award agreement) or upon the Reporting Person's separation from service with the Issuer due to the Reporting Person's death or "disability" (as described in the applicable award agreement).

SEC source: 0001104659-22-070277 · tm2218180-1_4seq1.xml · derivative · entry 1

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · Director · 10% owner

RA Capital Nexus Fund, L.P. · CIK 0001780117 · Director · 10% owner

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

Shah Rajeev M. · CIK 0001619841 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 16,000

Underlying: Common Stock · 16,000 shares

Expires 2032-06-07

F2 · derivative.exercise_date: All shares subject to the option vest 100% on the first to occur of (i) June 8, 2023 or (ii) the day immediately preceding the first annual meeting of the Issuer's stockholders to occur after the date of grant of the award. Each grant, to the extent outstanding and otherwise unvested, will become fully vested should a "change in control" of the Issuer occur (as described in the applicable award agreement) or upon the Zach Scheiner's, a Principal of the Adviser, separation from service with the Issuer due to the Mr. Scheiner's death or "disability" (as described in the applicable award agreement).

F1 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for RA Capital Healthcare Fund, L.P. (the "Fund") and RA Capital Nexus Fund, L.P. (the "Nexus Fund"). The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. The Adviser, the Adviser GP, Dr. Kolchinsky, and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein.

F2 · ownership.nature: All shares subject to the option vest 100% on the first to occur of (i) June 8, 2023 or (ii) the day immediately preceding the first annual meeting of the Issuer's stockholders to occur after the date of grant of the award. Each grant, to the extent outstanding and otherwise unvested, will become fully vested should a "change in control" of the Issuer occur (as described in the applicable award agreement) or upon the Zach Scheiner's, a Principal of the Adviser, separation from service with the Issuer due to the Mr. Scheiner's death or "disability" (as described in the applicable award agreement).

F3 · ownership.nature: Under Mr. Scheiner's arrangement with the Adviser, Mr. Scheiner holds the option for the benefit of the Fund and the Nexus Fund. Mr. Scheiner is obligated to turn over to the Adviser any net cash or stock received upon exercise of the option, which will offset advisory fees owed by the Fund and the Nexus Fund to the Adviser. The Reporting Persons therefore disclaim beneficial ownership of the option and underlying common stock except to the extent of their pecuniary interest.

SEC source: 0001209191-22-035844 · doc4.xml · derivative · entry 1

Shawver Laura · CIK 0001551891 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,000

Underlying: Common Stock · 16,000 shares

Expires 2032-06-07

F1 · derivative.exercise_date: All shares subject to the option vest 100% on the first to occur of (i) June 8, 2023 or (ii) the day immediately preceding the first annual meeting of the Issuer's stockholders to occur after the date of grant of the award. Each grant, to the extent outstanding and otherwise unvested, will become fully vested should a "change in control" of the Issuer occur (as described in the applicable award agreement) or upon the Reporting Person's separation from service with the Issuer due to the Reporting Person's death or "disability" (as described in the applicable award agreement).

SEC source: 0001209191-22-035822 · doc4.xml · derivative · entry 1

George Simeon · CIK 0001595117 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,000

Underlying: Common Stock · 16,000 shares

Expires 2032-06-07

F1 · derivative.exercise_date: All shares subject to the option vest 100% on the first to occur of (i) June 8, 2023 or (ii) the day immediately preceding the first annual meeting of the Issuer's stockholders to occur after the date of grant of the award. Each grant, to the extent outstanding and otherwise unvested, will become fully vested should a "change in control" of the Issuer occur (as described in the applicable award agreement) or upon the Reporting Person's separation from service with the Issuer due to the Reporting Person's death or "disability" (as described in the applicable award agreement).

SEC source: 0001209191-22-035818 · doc4.xml · derivative · entry 1

Dybbs Michael · CIK 0001601264 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,000

Underlying: Common Stock · 16,000 shares

Expires 2032-06-07

F1 · derivative.exercise_date: All shares subject to the option vest 100% on the first to occur of (i) June 8, 2023 or (ii) the day immediately preceding the first annual meeting of the Issuer's stockholders to occur after the date of grant of the award. Each grant, to the extent outstanding and otherwise unvested, will become fully vested should a "change in control" of the Issuer occur (as described in the applicable award agreement) or upon the Reporting Person's separation from service with the Issuer due to the Reporting Person's death or "disability" (as described in the applicable award agreement).

SEC source: 0001209191-22-035916 · doc4.xml · derivative · entry 1

Behbahani Ali · CIK 0001613867 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,000

Underlying: Common Stock · 16,000 shares

Expires 2032-06-07

F1 · derivative.exercise_date: All shares subject to the option vest 100% on the first to occur of (i) June 8, 2023 or (ii) the day immediately preceding the first annual meeting of the Issuer's stockholders to occur after the date of grant of the award. Each grant, to the extent outstanding and otherwise unvested, will become fully vested should a "change in control" of the Issuer occur (as described in the applicable award agreement) or upon the Reporting Person's separation from service with the Issuer due to the Reporting Person's death or "disability" (as described in the applicable award agreement).

SEC source: 0001209191-22-034811 · doc4.xml · derivative · entry 9

Brandenberger Ralph · CIK 0001853197 · Sr. VP, Technical Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 44,139

Underlying: Common Stock · 2,037 shares

Expires 2029-09-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the reporting person at least 90 days prior to the trading date.

F5 · derivative.exercise_date: The options exercised were fully vested. Unvested options will vest and become exercisable ratably in monthly installments until fully vested on September 5, 2023.

SEC source: 0001209191-22-034811 · doc4.xml · derivative · entry 8

Brandenberger Ralph · CIK 0001853197 · Sr. VP, Technical Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,426

Underlying: Common Stock · 1,358 shares

Expires 2029-09-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the reporting person at least 90 days prior to the trading date.

F4 · derivative.exercise_date: The options exercised were fully vested. Unvested options will vest and become exercisable ratably in monthly installments until fully vested on July 1, 2024.

SEC source: 0001209191-22-034811 · doc4.xml · derivative · entry 7

Brandenberger Ralph · CIK 0001853197 · Sr. VP, Technical Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,785

Underlying: Common Stock · 405 shares

Expires 2029-05-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the reporting person at least 90 days prior to the trading date.

F3 · derivative.exercise_date: The options exercised were fully vested. Unvested options will vest and become exercisable ratably in monthly installments until fully vested on December 6, 2022.

SEC source: 0001209191-22-034811 · doc4.xml · derivative · entry 6

Brandenberger Ralph · CIK 0001853197 · Sr. VP, Technical Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,367

Underlying: Common Stock · 340 shares

Expires 2028-07-18

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the reporting person at least 90 days prior to the trading date.

F2 · derivative.exercise_date: This stock option is fully vested.

SEC source: 0001209191-22-034811 · doc4.xml · nonDerivative · entry 5

Brandenberger Ralph · CIK 0001853197 · Sr. VP, Technical Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,300

F1 · kind: The transactions reported in this Form 4 were effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the reporting person at least 90 days prior to the trading date.

SEC source: 0001209191-22-034811 · doc4.xml · nonDerivative · entry 4

Brandenberger Ralph · CIK 0001853197 · Sr. VP, Technical Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,440

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the reporting person at least 90 days prior to the trading date.

SEC source: 0001209191-22-034811 · doc4.xml · nonDerivative · entry 3

Brandenberger Ralph · CIK 0001853197 · Sr. VP, Technical Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,403

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the reporting person at least 90 days prior to the trading date.

SEC source: 0001209191-22-034811 · doc4.xml · nonDerivative · entry 2

Brandenberger Ralph · CIK 0001853197 · Sr. VP, Technical Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,045

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the reporting person at least 90 days prior to the trading date.

SEC source: 0001209191-22-034811 · doc4.xml · nonDerivative · entry 1

Brandenberger Ralph · CIK 0001853197 · Sr. VP, Technical Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,640

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The transactions reported in this Form 4 were effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the reporting person at least 90 days prior to the trading date.

SEC source: 0001209191-22-026258 · doc4.xml · nonDerivative · entry 2

George Simeon · CIK 0001595117 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 666,666

F3 · price: SR One Co-Invest X, LLC purchased 666,666 shares of common stock of the issuer in connection with the issuer's public offering.

F4 · ownership.nature: The reported securities are held directly by SR One Co-Invest X, LLC. SR One Co-Invest Manager X, LLC is the managing member of SR One Co-Invest X, LLC, and SR One Capital Management, LLC is the managing member of SR One Co-Invest Manager X, LLC. Simeon George is the managing member of SR One Capital Management, LLC. Each of SR One Co-Invest Manager X, LLC, SR One Capital Management, LLC and Mr. George may each be deemed to have shared power to vote or dispose of these shares, and each disclaims beneficial ownership of the shares except to the extent of any pecuniary interest therein.

SEC source: 0001209191-22-026258 · doc4.xml · nonDerivative · entry 1

George Simeon · CIK 0001595117 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 666,667

F1 · price: SR One Co-Invest IX, LLC purchased 666,667 shares of common stock of the issuer in connection with the issuer's public offering.

F2 · ownership.nature: The reported securities are held directly by SR One Co-Invest IX, LLC. SR One Co-Invest Manager IX, LLC is the managing member of SR One Co-Invest IX, LLC, and SR One Capital Management, LLC is the managing member of SR One Co-Invest Manager IX, LLC. Simeon George is the managing member of SR One Capital Management, LLC. Each of SR One Co-Invest Manager IX, LLC, SR One Capital Management, LLC and Mr. George may each be deemed to have shared power to vote or dispose of these shares, and each disclaims beneficial ownership of the shares except to the extent of any pecuniary interest therein.

SEC source: 0001104659-22-052318 · tm2213914-1_4.xml · nonDerivative · entry 1

RA CAPITAL MANAGEMENT, L.P. · CIK 0001346824 · Director · 10% owner

RA Capital Healthcare Fund LP · CIK 0001315082 · Director · 10% owner

RA Capital Nexus Fund, L.P. · CIK 0001780117 · Director · 10% owner

Kolchinsky Peter · CIK 0001384859 · Director · 10% owner

Shah Rajeev M. · CIK 0001619841 · Director · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnotes

Disclosed balance after: 7,805,129

F1 · price: RA Capital Healthcare Fund, L.P (the "Fund") acquired 2,200,00 shares of common stock from the issuer on 4/26/22 for a price of $15 per share.

F2 · balance_after: These securities include 7,050,818 shares held directly by the Fund and 754,311 shares held by the RA Capital Nexus Fund, L.P. (the "Nexus Fund").

F2 · ownership.nature: These securities include 7,050,818 shares held directly by the Fund and 754,311 shares held by the RA Capital Nexus Fund, L.P. (the "Nexus Fund").

F3 · ownership.nature: RA Capital Management, L.P. (the "Adviser") is the investment manager for the Fund and the Nexus Fund. The general partner of the Adviser is RA Capital Management GP, LLC (the "Adviser GP"), of which Dr. Peter Kolchinsky and Mr. Rajeev Shah are the managing members. The Adviser, the Adviser GP, Dr. Kolchinsky and Mr. Shah disclaim beneficial ownership of any of the reported securities, except to the extent of their pecuniary interest therein.

SEC source: 0001209191-22-021455 · doc4.xml · derivative · entry 1

Thedinga Angela · CIK 0001804588 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,000

Underlying: Common Stock · 32,000 shares

Expires 2032-03-27

F1 · derivative.exercise_date: This option is scheduled to vest and become exercisable in three substantially equal installments on each of the first, second and third anniversaries of the grant date, subject to the Reporting Person's continued service to the Issuer.

SEC source: 0001209191-22-003752 · doc4.xml · derivative · entry 2

Brandenberger Ralph · CIK 0001853197 · Sr. VP, Technical Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,400

Underlying: Common Stock · 31,400 shares

Expires 2032-01-13

F2 · derivative.exercise_date: This option is scheduled to vest and become exercisable in 48 equal monthly installments occurring on the completion of each successive month of the Reporting Person's service to the Issuer following January 14, 2022.

SEC source: 0001209191-22-003752 · doc4.xml · nonDerivative · entry 1

Brandenberger Ralph · CIK 0001853197 · Sr. VP, Technical Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,300

F1 · shares: Represents Restricted Stock Units ("RSUs") which vest in four equal annual installments beginning on the first anniversary of the grant date. Each RSU represents a contingent right to receive one share of Common Stock of the Issuer.

SEC source: 0001209191-22-003758 · doc4.xml · derivative · entry 2

Mahmood Nadir · CIK 0001816598 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 76,800

Underlying: Common Stock · 76,800 shares

Expires 2032-01-13

F3 · derivative.exercise_date: This option is scheduled to vest and become exercisable in 48 equal monthly installments occurring on the completion of each successive month of the Reporting Person's service to the Issuer following January 14, 2022.

SEC source: 0001209191-22-003758 · doc4.xml · nonDerivative · entry 1

Mahmood Nadir · CIK 0001816598 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,088

F1 · shares: Represents Restricted Stock Units ("RSUs") which vest in four equal annual installments beginning on the first anniversary of the grant date. Each RSU represents a contingent right to receive one share of Common Stock of the Issuer.

F2 · balance_after: Includes 2,118 shares acquired upon early exercise of an option, which are subject to forfeiture until they vest.

SEC source: 0001209191-22-003754 · doc4.xml · derivative · entry 2

Trager James · CIK 0001816549 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 76,800

Underlying: Common Stock · 76,800 shares

Expires 2032-01-13

F2 · derivative.exercise_date: This option is scheduled to vest and become exercisable in 48 equal monthly installments occurring on the completion of each successive month of the Reporting Person's service to the Issuer following January 14, 2022.

SEC source: 0001209191-22-003754 · doc4.xml · nonDerivative · entry 1

Trager James · CIK 0001816549 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 57,172

F1 · shares: Represents Restricted Stock Units ("RSUs") which vest in four equal annual installments beginning on the first anniversary of the grant date. Each RSU represents a contingent right to receive one share of Common Stock of the Issuer.