MPLT

SEC source: 0001789970-26-000006 · form4-04172026_040411.xml · nonDerivative · entry 2

Hanson Kristopher · CIK 0001789970 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 190,390

F1 · shares: Represents the number of shares required to be sold to cover the statutory tax withholding obligations in connection with the vesting of the restricted stock units.

F4 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.2201 to $27.2197 inclusive.

SEC source: 0002021198-26-000013 · form4-04172026_040402.xml · nonDerivative · entry 1

Malenka Robert C. · CIK 0002021198 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 316,466

F1 · kind: This transaction was made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 26, 2025.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $26.35 to $27.29, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0002021238-26-000006 · form4-04172026_040415.xml · nonDerivative · entry 1

Kreitzer Anatol · CIK 0002021238 · Chief Discovery Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 256,612

F1 · shares: Represents the number of shares required to be sold to cover the statutory tax withholding obligations in connection with the vesting of the restricted stock units.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.6045 to $26.6093 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0002021256-26-000006 · form4-04172026_040410.xml · nonDerivative · entry 1

Setia Vishwas · CIK 0002021256 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 392,743

F1 · shares: Represents the number of shares required to be sold to cover the statutory tax withholding obligations in connection with the vesting of the restricted stock units.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.33 to $27.29 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (3) and (4).

SEC source: 0002021233-26-000006 · form4-04172026_040406.xml · nonDerivative · entry 1

Foff Erin Pennock · CIK 0002021233 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 401,946

F1 · shares: Represents the number of shares required to be sold to cover the statutory tax withholding obligations in connection with the vesting of the restricted stock units.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.33 to $27.29 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (3) and (5).

F3 · balance_after: Includes 155 shares acquired under the Issuer's stock purchase plan on March 31, 2026.

SEC source: 0001658918-26-000006 · form4-04172026_040404.xml · nonDerivative · entry 1

Kroeger Christopher A. · CIK 0001658918 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,640,616

F1 · shares: Represents the number of shares required to be sold to cover the statutory tax withholding obligations in connection with the vesting of the restricted stock units.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.33 to $27.29 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (3) and (4).

SEC source: 0001709954-26-000006 · form4-04172026_040413.xml · nonDerivative · entry 1

GILLIS JONATHAN · CIK 0001709954 · CAAO and PAO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 251,054

F1 · shares: Represents the number of shares required to be sold to cover the statutory tax withholding obligations in connection with the vesting of the restricted stock units.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.6045 to $26.6093 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

F3 · balance_after: Includes 121 shares acquired under the Issuer's stock purchase plan on March 31, 2026.

SEC source: 0001728746-26-000006 · form4-04172026_040408.xml · nonDerivative · entry 1

Lillie James Woodruff · CIK 0001728746 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 297,940

F1 · shares: Represents the number of shares required to be sold to cover the statutory tax withholding obligations in connection with the vesting of the restricted stock units.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.33 to $27.29 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (3) and (5).

F3 · balance_after: Includes 808 shares acquired under the Issuer's stock purchase plan on March 31, 2026.

SEC source: 0001789970-26-000006 · form4-04172026_040411.xml · nonDerivative · entry 1

Hanson Kristopher · CIK 0001789970 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 190,463

F1 · shares: Represents the number of shares required to be sold to cover the statutory tax withholding obligations in connection with the vesting of the restricted stock units.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $26.33 to $27.29 inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (3) and (5).

F3 · balance_after: Includes 410 shares acquired under the Issuer's stock purchase plan on March 31, 2026.

SEC source: 0002021198-26-000011 · form4-02242026_110209.xml · nonDerivative · entry 4

Malenka Robert C. · CIK 0002021198 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 325,059

F1 · shares: Represents sales of shares of common stock by the Reporting Person to cover tax obligations in connection with the settlement of restricted stock unit awards. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The securities of the Issuer retained by the Reporting Person remain subject to the terms a lock-up agreement entered into with the underwriters for the Issuer's initial public offering, pursuant to which the Reporting Person agreed, subject to certain exceptions, not to directly or indirectly sell or otherwise transfer securities of the Issuer for a period of 180 days following the date of the final prospectus relating to the initial public offering, which was October 26, 2025.

F5 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $18.01 to $18.24, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0002021198-26-000011 · form4-02242026_110209.xml · nonDerivative · entry 3

Malenka Robert C. · CIK 0002021198 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 325,795

F1 · shares: Represents sales of shares of common stock by the Reporting Person to cover tax obligations in connection with the settlement of restricted stock unit awards. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The securities of the Issuer retained by the Reporting Person remain subject to the terms a lock-up agreement entered into with the underwriters for the Issuer's initial public offering, pursuant to which the Reporting Person agreed, subject to certain exceptions, not to directly or indirectly sell or otherwise transfer securities of the Issuer for a period of 180 days following the date of the final prospectus relating to the initial public offering, which was October 26, 2025.

F4 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $19.00 to $19.15, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0002021198-26-000011 · form4-02242026_110209.xml · nonDerivative · entry 2

Malenka Robert C. · CIK 0002021198 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 326,271

F1 · shares: Represents sales of shares of common stock by the Reporting Person to cover tax obligations in connection with the settlement of restricted stock unit awards. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The securities of the Issuer retained by the Reporting Person remain subject to the terms a lock-up agreement entered into with the underwriters for the Issuer's initial public offering, pursuant to which the Reporting Person agreed, subject to certain exceptions, not to directly or indirectly sell or otherwise transfer securities of the Issuer for a period of 180 days following the date of the final prospectus relating to the initial public offering, which was October 26, 2025.

F3 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $18.00 to $18.99, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001470798-26-000002 · form4-02202026_060201.xml · nonDerivative · entry 3

Pavlov George · CIK 0001470798 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

F3 · price: The price reported is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $17.74 to $17.95, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0002021198-26-000011 · form4-02242026_110209.xml · nonDerivative · entry 1

Malenka Robert C. · CIK 0002021198 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 337,059

F1 · shares: Represents sales of shares of common stock by the Reporting Person to cover tax obligations in connection with the settlement of restricted stock unit awards. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The securities of the Issuer retained by the Reporting Person remain subject to the terms a lock-up agreement entered into with the underwriters for the Issuer's initial public offering, pursuant to which the Reporting Person agreed, subject to certain exceptions, not to directly or indirectly sell or otherwise transfer securities of the Issuer for a period of 180 days following the date of the final prospectus relating to the initial public offering, which was October 26, 2025.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $18.00 to $18.10, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0001470798-26-000002 · form4-02202026_060201.xml · nonDerivative · entry 2

Pavlov George · CIK 0001470798 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,080

F2 · price: The price reported is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $17.28 to $17.75, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0001470798-26-000002 · form4-02202026_060201.xml · nonDerivative · entry 1

Pavlov George · CIK 0001470798 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,658

F1 · price: The price reported is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $17.22 to $17.72, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote.

SEC source: 0002021198-26-000009 · form4-02192026_120233.xml · nonDerivative · entry 1

Malenka Robert C. · CIK 0002021198 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 339,254

F1 · shares: Represents sales of shares of common stock by the Reporting Person to cover tax obligations in connection with the settlement of restricted stock unit awards. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The securities of the Issuer retained by the Reporting Person remain subject to the terms a lock-up agreement entered into with the underwriters for the Issuer's initial public offering, pursuant to which the Reporting Person agreed, subject to certain exceptions, not to directly or indirectly sell or otherwise transfer securities of the Issuer for a period of 180 days following the date of the final prospectus relating to the initial public offering, which was October 26, 2025.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $18.00 to $18.59, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0002021198-26-000007 · form4-02122026_050201.xml · nonDerivative · entry 2

Malenka Robert C. · CIK 0002021198 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 351,370

F1 · shares: Represents sales of shares of common stock by the Reporting Person to cover tax obligations in connection with the settlement of restricted stock unit awards. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The securities of the Issuer retained by the Reporting Person remain subject to the terms a lock-up agreement entered into with the underwriters for the Issuer's initial public offering, pursuant to which the Reporting Person agreed, subject to certain exceptions, not to directly or indirectly sell or otherwise transfer securities of the Issuer for a period of 180 days following the date of the final prospectus relating to the initial public offering, which was October 26, 2025.

SEC source: 0001998937-26-000002 · form4-02122026_050203.xml · nonDerivative · entry 1

Garnett Timothy John · CIK 0001998937 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 14,124

F1 · price: The price reported is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $17.76 to $17.90, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares purchase at each separate price within the range set forth in this footnote.

F2 · ownership.nature: The shares are held by the Timothy J Garnett Revocable Trust Dated U/A 09/22/2021, of which the Reporting Person is the sole trustee and has voting and dispositive power.

SEC source: 0002021198-26-000007 · form4-02122026_050201.xml · nonDerivative · entry 1

Malenka Robert C. · CIK 0002021198 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 351,611

F1 · shares: Represents sales of shares of common stock by the Reporting Person to cover tax obligations in connection with the settlement of restricted stock unit awards. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The securities of the Issuer retained by the Reporting Person remain subject to the terms a lock-up agreement entered into with the underwriters for the Issuer's initial public offering, pursuant to which the Reporting Person agreed, subject to certain exceptions, not to directly or indirectly sell or otherwise transfer securities of the Issuer for a period of 180 days following the date of the final prospectus relating to the initial public offering, which was October 26, 2025.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $18.00 to $18.41, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0002021238-26-000004 · form4-02092026_050207.xml · derivative · entry 2

Kreitzer Anatol · CIK 0002021238 · Chief Discovery Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,455

Underlying: Voting Common Stock · 24,455 shares

Expires 2036-02-04

F3 · derivative.exercise_date: 1/4th of the total shares underlying the option shall vest on February 5, 2027, and 1/48th of the total shares shall vest each month thereafter on the same day of the month, subject to the Reporting Person's continued service through each vesting date.

SEC source: 0002021238-26-000004 · form4-02092026_050207.xml · nonDerivative · entry 1

Kreitzer Anatol · CIK 0002021238 · Chief Discovery Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 259,928

F1 · shares: Represents a restricted stock unit ("RSU") award. 1/4th of the RSUs shall vest on January 1, 2027, and 1/16th of the RSUs shall vest on each subsequent April 1, July 1, October 1 and January 1 thereafter, subject to the Reporting Person's continued service through each vesting date.

F2 · price: Each RSU represents a contingent right to receive one share of voting common stock of the Issuer.

SEC source: 0002021256-26-000004 · form4-02092026_050210.xml · derivative · entry 2

Setia Vishwas · CIK 0002021256 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,395

Underlying: Voting Common Stock · 31,395 shares

Expires 2036-02-04

F3 · derivative.exercise_date: 1/4th of the total shares underlying the option shall vest on February 5, 2027, and 1/48th of the total shares shall vest each month thereafter on the same day of the month, subject to the Reporting Person's continued service through each vesting date.

SEC source: 0002021256-26-000004 · form4-02092026_050210.xml · nonDerivative · entry 1

Setia Vishwas · CIK 0002021256 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 395,549

F1 · shares: Represents a restricted stock unit ("RSU") award. 1/4th of the RSUs shall vest on January 1, 2027, and 1/16th of the RSUs shall vest on each subsequent April 1, July 1, October 1 and January 1 thereafter, subject to the Reporting Person's continued service through each vesting date.

F2 · price: Each RSU represents a contingent right to receive one share of voting common stock of the Issuer.

SEC source: 0002021233-26-000004 · form4-02092026_050203.xml · derivative · entry 2

Foff Erin Pennock · CIK 0002021233 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 54,240

Underlying: Voting Common Stock · 54,240 shares

Expires 2036-02-04

F3 · derivative.exercise_date: 1/4th of the total shares underlying the option shall vest on February 5, 2027, and 1/48th of the total shares shall vest each month thereafter on the same day of the month, subject to the Reporting Person's continued service through each vesting date.

SEC source: 0002021233-26-000004 · form4-02092026_050203.xml · nonDerivative · entry 1

Foff Erin Pennock · CIK 0002021233 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 403,835

F1 · shares: Represents a restricted stock unit ("RSU") award. 1/4th of the RSUs shall vest on January 1, 2027, and 1/16th of the RSUs shall vest on each subsequent April 1, July 1, October 1 and January 1 thereafter, subject to the Reporting Person's continued service through each vesting date.

F2 · price: Each RSU represents a contingent right to receive one share of voting common stock of the Issuer.

SEC source: 0001658918-26-000004 · form4-02092026_050201.xml · derivative · entry 3

Kroeger Christopher A. · CIK 0001658918 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 93,955

Underlying: Voting Common Stock · 93,955 shares

Expires 2036-02-04

F4 · derivative.exercise_date: 1/4th of the total shares underlying the option shall vest on February 5, 2027, and 1/48th of the total shares shall vest each month thereafter on the same day of the month, subject to the Reporting Person's continued service through each vesting date.

SEC source: 0001658918-26-000004 · form4-02092026_050201.xml · nonDerivative · entry 1

Kroeger Christopher A. · CIK 0001658918 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,649,751

F1 · shares: Represents a restricted stock unit ("RSU") award. 1/4th of the RSUs shall vest on January 1, 2027, and 1/16th of the RSUs shall vest on each subsequent April 1, July 1, October 1 and January 1 thereafter, subject to the Reporting Person's continued service through each vesting date.

F2 · price: Each RSU represents a contingent right to receive one share of voting common stock of the Issuer.

SEC source: 0001709954-26-000004 · form4-02092026_050212.xml · derivative · entry 2

GILLIS JONATHAN · CIK 0001709954 · CAAO and PAO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,455

Underlying: Voting Common Stock · 24,455 shares

Expires 2036-02-04

F3 · derivative.exercise_date: 1/4th of the total shares underlying the option shall vest on February 5, 2027, and 1/48th of the total shares shall vest each month thereafter on the same day of the month, subject to the Reporting Person's continued service through each vesting date.

SEC source: 0001709954-26-000004 · form4-02092026_050212.xml · nonDerivative · entry 1

GILLIS JONATHAN · CIK 0001709954 · CAAO and PAO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 254,523

F1 · shares: Represents a restricted stock unit ("RSU") award. 1/4th of the RSUs shall vest on January 1, 2027, and 1/16th of the RSUs shall vest on each subsequent April 1, July 1, October 1 and January 1 thereafter, subject to the Reporting Person's continued service through each vesting date.

F2 · price: Each RSU represents a contingent right to receive one share of voting common stock of the Issuer.

SEC source: 0001728746-26-000004 · form4-02092026_050209.xml · derivative · entry 2

Lillie James Woodruff · CIK 0001728746 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,395

Underlying: Voting Common Stock · 31,395 shares

Expires 2036-02-04

F3 · derivative.exercise_date: 1/4th of the total shares underlying the option shall vest on February 5, 2027, and 1/48th of the total shares shall vest each month thereafter on the same day of the month, subject to the Reporting Person's continued service through each vesting date.

SEC source: 0001728746-26-000004 · form4-02092026_050209.xml · nonDerivative · entry 1

Lillie James Woodruff · CIK 0001728746 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 298,862

F1 · shares: Represents a restricted stock unit ("RSU") award. 1/4th of the RSUs shall vest on January 1, 2027, and 1/16th of the RSUs shall vest on each subsequent April 1, July 1, October 1 and January 1 thereafter, subject to the Reporting Person's continued service through each vesting date.

F2 · price: Each RSU represents a contingent right to receive one share of voting common stock of the Issuer.

SEC source: 0001789970-26-000004 · form4-02092026_050205.xml · derivative · entry 2

Hanson Kristopher · CIK 0001789970 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 31,395

Underlying: Voting Common Stock · 31,395 shares

Expires 2036-02-04

F3 · derivative.exercise_date: 1/4th of the total shares underlying the option shall vest on February 5, 2027, and 1/48th of the total shares shall vest each month thereafter on the same day of the month, subject to the Reporting Person's continued service through each vesting date.

SEC source: 0001789970-26-000004 · form4-02092026_050205.xml · nonDerivative · entry 1

Hanson Kristopher · CIK 0001789970 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 191,582

F1 · shares: Represents a restricted stock unit ("RSU") award. 1/4th of the RSUs shall vest on January 1, 2027, and 1/16th of the RSUs shall vest on each subsequent April 1, July 1, October 1 and January 1 thereafter, subject to the Reporting Person's continued service through each vesting date.

F2 · price: Each RSU represents a contingent right to receive one share of voting common stock of the Issuer.

SEC source: 0002021198-26-000005 · form4-02052026_020204.xml · nonDerivative · entry 2

Malenka Robert C. · CIK 0002021198 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 358,233

F1 · shares: Represents sales of shares of common stock by the Reporting Person to cover tax obligations in connection with the settlement of restricted stock unit awards. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The securities of the Issuer retained by the Reporting Person remain subject to the terms a lock-up agreement entered into with the underwriters for the Issuer's initial public offering, pursuant to which the Reporting Person agreed, subject to certain exceptions, not to directly or indirectly sell or otherwise transfer securities of the Issuer for a period of 180 days following the date of the final prospectus relating to the initial public offering, which was October 26, 2025.

SEC source: 0002021198-26-000005 · form4-02052026_020204.xml · nonDerivative · entry 1

Malenka Robert C. · CIK 0002021198 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 358,234

F1 · shares: Represents sales of shares of common stock by the Reporting Person to cover tax obligations in connection with the settlement of restricted stock unit awards. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The securities of the Issuer retained by the Reporting Person remain subject to the terms a lock-up agreement entered into with the underwriters for the Issuer's initial public offering, pursuant to which the Reporting Person agreed, subject to certain exceptions, not to directly or indirectly sell or otherwise transfer securities of the Issuer for a period of 180 days following the date of the final prospectus relating to the initial public offering, which was October 26, 2025.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $18.00 to $18.14, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0002021198-26-000003 · form4-01312026_010139.xml · nonDerivative · entry 4

Malenka Robert C. · CIK 0002021198 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 365,273

F1 · shares: Represents sales of shares of common stock by the Reporting Person to cover tax obligations in connection with the settlement of restricted stock unit awards. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The securities of the Issuer retained by the Reporting Person remain subject to the terms a lock-up agreement entered into with the underwriters for the Issuer's initial public offering, pursuant to which the Reporting Person agreed, subject to certain exceptions, not to directly or indirectly sell or otherwise transfer securities of the Issuer for a period of 180 days following the date of the final prospectus relating to the initial public offering, which was October 26, 2025.

F5 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $18.00 to $18.50, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0002021198-26-000003 · form4-01312026_010139.xml · nonDerivative · entry 3

Malenka Robert C. · CIK 0002021198 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 371,885

F1 · shares: Represents sales of shares of common stock by the Reporting Person to cover tax obligations in connection with the settlement of restricted stock unit awards. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The securities of the Issuer retained by the Reporting Person remain subject to the terms a lock-up agreement entered into with the underwriters for the Issuer's initial public offering, pursuant to which the Reporting Person agreed, subject to certain exceptions, not to directly or indirectly sell or otherwise transfer securities of the Issuer for a period of 180 days following the date of the final prospectus relating to the initial public offering, which was October 26, 2025.

F4 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $18.13 to $19.09, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0002021198-26-000003 · form4-01312026_010139.xml · nonDerivative · entry 2

Malenka Robert C. · CIK 0002021198 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 393,147

F1 · shares: Represents sales of shares of common stock by the Reporting Person to cover tax obligations in connection with the settlement of restricted stock unit awards. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The securities of the Issuer retained by the Reporting Person remain subject to the terms a lock-up agreement entered into with the underwriters for the Issuer's initial public offering, pursuant to which the Reporting Person agreed, subject to certain exceptions, not to directly or indirectly sell or otherwise transfer securities of the Issuer for a period of 180 days following the date of the final prospectus relating to the initial public offering, which was October 26, 2025.

F3 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $19.02 to $19.11, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0002021198-26-000003 · form4-01312026_010139.xml · nonDerivative · entry 1

Malenka Robert C. · CIK 0002021198 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 393,811

F1 · shares: Represents sales of shares of common stock by the Reporting Person to cover tax obligations in connection with the settlement of restricted stock unit awards. Each restricted stock unit represents a contingent right to receive one share of common stock of the Issuer. The securities of the Issuer retained by the Reporting Person remain subject to the terms a lock-up agreement entered into with the underwriters for the Issuer's initial public offering, pursuant to which the Reporting Person agreed, subject to certain exceptions, not to directly or indirectly sell or otherwise transfer securities of the Issuer for a period of 180 days following the date of the final prospectus relating to the initial public offering, which was October 26, 2025.

F2 · price: The price reported is a weighted average sales price. The shares were sold in multiple transactions at prices ranging from $18.01 to $19.01, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote.

SEC source: 0002021238-26-000002 · form4-01292026_040109.xml · nonDerivative · entry 1

Kreitzer Anatol · CIK 0002021238 · Chief Discovery Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 253,908

F1 · shares: Represents the number of shares withheld by the Issuer to satisfy tax withholding obligations in connection with the settlement of restricted stock unit awards. The securities of the Issuer retained by the Reporting Person remain subject to the terms a lock-up agreement entered into with the underwriters for the Issuer's initial public offering, pursuant to which the Reporting Person agreed, subject to certain exceptions, not to directly or indirectly sell or otherwise transfer securities of the Issuer for a period of 180 days following the date of the final prospectus relating to the initial public offering, which was October 26, 2025.

SEC source: 0002021256-26-000002 · form4-01292026_040112.xml · nonDerivative · entry 1

Setia Vishwas · CIK 0002021256 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 387,819

F1 · shares: Represents the number of shares withheld by the Issuer to satisfy tax withholding obligations in connection with the settlement of a restricted stock unit award. The securities of the Issuer retained by the Reporting Person remain subject to the terms a lock-up agreement entered into with the underwriters for the Issuer's initial public offering, pursuant to which the Reporting Person agreed, subject to certain exceptions, not to directly or indirectly sell or otherwise transfer securities of the Issuer for a period of 180 days following the date of the final prospectus relating to the initial public offering, which was October 26, 2025.

SEC source: 0002021233-26-000002 · form4-01292026_040101.xml · nonDerivative · entry 1

Foff Erin Pennock · CIK 0002021233 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 390,475

F1 · shares: Represents the number of shares withheld by the Issuer to satisfy tax withholding obligations in connection with the settlement of restricted stock unit awards. The securities of the Issuer retained by the Reporting Person remain subject to the terms a lock-up agreement entered into with the underwriters for the Issuer's initial public offering, pursuant to which the Reporting Person agreed, subject to certain exceptions, not to directly or indirectly sell or otherwise transfer securities of the Issuer for a period of 180 days following the date of the final prospectus relating to the initial public offering, which was October 26, 2025.

SEC source: 0001658918-26-000002 · form4-01292026_040107.xml · nonDerivative · entry 1

Kroeger Christopher A. · CIK 0001658918 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,626,606

F1 · shares: Represents the number of shares withheld by the Issuer to satisfy tax withholding obligations in connection with the settlement of restricted stock unit awards. The securities of the Issuer retained by the Reporting Person remain subject to the terms a lock-up agreement entered into with the underwriters for the Issuer's initial public offering, pursuant to which the Reporting Person agreed, subject to certain exceptions, not to directly or indirectly sell or otherwise transfer securities of the Issuer for a period of 180 days following the date of the final prospectus relating to the initial public offering, which was October 26, 2025.

SEC source: 0001709954-26-000002 · form4-01292026_040103.xml · nonDerivative · entry 1

GILLIS JONATHAN · CIK 0001709954 · CAAO and PAO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 248,503

F1 · shares: Represents the number of shares withheld by the Issuer to satisfy tax withholding obligations in connection with the settlement of restricted stock unit awards. The securities of the Issuer retained by the Reporting Person remain subject to the terms a lock-up agreement entered into with the underwriters for the Issuer's initial public offering, pursuant to which the Reporting Person agreed, subject to certain exceptions, not to directly or indirectly sell or otherwise transfer securities of the Issuer for a period of 180 days following the date of the final prospectus relating to the initial public offering, which was October 26, 2025.

SEC source: 0001728746-26-000002 · form4-01292026_040111.xml · nonDerivative · entry 1

Lillie James Woodruff · CIK 0001728746 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 291,132

F1 · shares: Represents the number of shares withheld by the Issuer to satisfy tax withholding obligations in connection with the settlement of restricted stock unit awards. The securities of the Issuer retained by the Reporting Person remain subject to the terms a lock-up agreement entered into with the underwriters for the Issuer's initial public offering, pursuant to which the Reporting Person agreed, subject to certain exceptions, not to directly or indirectly sell or otherwise transfer securities of the Issuer for a period of 180 days following the date of the final prospectus relating to the initial public offering, which was October 26, 2025.

SEC source: 0001789970-26-000002 · form4-01292026_040105.xml · nonDerivative · entry 1

Hanson Kristopher · CIK 0001789970 · General Counsel

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 183,852

F1 · shares: Represents the number of shares withheld by the Issuer to satisfy tax withholding obligations in connection with the settlement of restricted stock unit awards. The securities of the Issuer retained by the Reporting Person remain subject to the terms a lock-up agreement entered into with the underwriters for the Issuer's initial public offering, pursuant to which the Reporting Person agreed, subject to certain exceptions, not to directly or indirectly sell or otherwise transfer securities of the Issuer for a period of 180 days following the date of the final prospectus relating to the initial public offering, which was October 26, 2025.

SEC source: 0002021198-25-000006 · form4-10282025_041005.xml · derivative · entry 4

Malenka Robert C. · CIK 0002021198 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 0

Underlying: Voting Common Stock · 3,895 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: The Series C Preferred Stock automatically converted into voting common stock upon the closing of the Issuer's initial public offering for no additional consideration, on a 1-for-16.8 basis, and had no expiration date.

F3 · derivative.exercise_date: The Series C Preferred Stock automatically converted into voting common stock upon the closing of the Issuer's initial public offering for no additional consideration, on a 1-for-16.8 basis, and had no expiration date.

F3 · derivative.expiration_date: The Series C Preferred Stock automatically converted into voting common stock upon the closing of the Issuer's initial public offering for no additional consideration, on a 1-for-16.8 basis, and had no expiration date.

F4 · ownership.nature: The shares are held by the Robert C. Malenka Living Trust U/A DTD 08/21/2012, of which the Reporting Person is the sole trustee and has voting and dispositive power.

SEC source: 0002021198-25-000006 · form4-10282025_041005.xml · nonDerivative · entry 2

Malenka Robert C. · CIK 0002021198 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See footnote

Disclosed balance after: 31,672

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: The Series C Preferred Stock automatically converted into voting common stock upon the closing of the Issuer's initial public offering for no additional consideration, on a 1-for-16.8 basis, and had no expiration date.

F4 · ownership.nature: The shares are held by the Robert C. Malenka Living Trust U/A DTD 08/21/2012, of which the Reporting Person is the sole trustee and has voting and dispositive power.

SEC source: 0001658918-25-000008 · form4-10282025_041001.xml · derivative · entry 5

Kroeger Christopher A. · CIK 0001658918 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Voting Common Stock · 3,895 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: The Series C Preferred Stock automatically converted into voting common stock upon the closing of the Issuer's IPO for no additional consideration, on a 1-for-16.8 basis, and had no expiration date.

F3 · derivative.exercise_date: The Series C Preferred Stock automatically converted into voting common stock upon the closing of the Issuer's IPO for no additional consideration, on a 1-for-16.8 basis, and had no expiration date.

F3 · derivative.expiration_date: The Series C Preferred Stock automatically converted into voting common stock upon the closing of the Issuer's IPO for no additional consideration, on a 1-for-16.8 basis, and had no expiration date.