KRYS

SEC source: 0001298709-24-000011 · wk-form4_1718152304.xml · nonDerivative · entry 6

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,593,707

F1 · kind: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 11, 2023, and contemplated quarterly sales of 25,000 shares with a limit price of $100.00 per share. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F7 · price: The transaction was executed in multiple trades ranging from $176.21 to $177.19. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298709-24-000011 · wk-form4_1718152304.xml · nonDerivative · entry 5

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,599,412

F1 · kind: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 11, 2023, and contemplated quarterly sales of 25,000 shares with a limit price of $100.00 per share. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F6 · price: The transaction was executed in multiple trades ranging from $175.21 to $176.20. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298709-24-000011 · wk-form4_1718152304.xml · nonDerivative · entry 4

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,603,962

F1 · kind: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 11, 2023, and contemplated quarterly sales of 25,000 shares with a limit price of $100.00 per share. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F5 · price: The transaction was executed in multiple trades ranging from $174.21 to $175.19. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298709-24-000011 · wk-form4_1718152304.xml · nonDerivative · entry 3

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,607,962

F1 · kind: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 11, 2023, and contemplated quarterly sales of 25,000 shares with a limit price of $100.00 per share. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F4 · price: The transaction was executed in multiple trades ranging from $172.85 to $173.81. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298709-24-000011 · wk-form4_1718152304.xml · nonDerivative · entry 2

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,609,280

F1 · kind: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 11, 2023, and contemplated quarterly sales of 25,000 shares with a limit price of $100.00 per share. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F3 · price: The transaction was executed in multiple trades ranging from $171.83 to $172.76. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298709-24-000011 · wk-form4_1718152304.xml · nonDerivative · entry 1

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,611,162

F1 · kind: The sales reported were pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 11, 2023, and contemplated quarterly sales of 25,000 shares with a limit price of $100.00 per share. The Rule 10b5-1 trading plan has reached the maximum number of shares to be sold under such plan and has terminated.

F2 · price: The transaction was executed in multiple trades ranging from $170.75 to $171.74. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001532023-24-000008 · wk-form4_1716416222.xml · derivative · entry 5

Gangolli Julian S · CIK 0001532023 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 20,000 shares

Expires 2029-03-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: The options were awarded on March 1, 2019 and vested monthly over a three-year period.

SEC source: 0001532023-24-000008 · wk-form4_1716416222.xml · nonDerivative · entry 4

Gangolli Julian S · CIK 0001532023 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

F3 · price: The transaction was executed in multiple trades ranging from $165.160 to $166.000. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001532023-24-000008 · wk-form4_1716416222.xml · nonDerivative · entry 3

Gangolli Julian S · CIK 0001532023 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,980

F2 · price: The transaction was executed in multiple trades ranging from $164.085 to $164.850. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001532023-24-000008 · wk-form4_1716416222.xml · nonDerivative · entry 2

Gangolli Julian S · CIK 0001532023 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,070

F1 · price: The transaction was executed in multiple trades ranging from $163.080 to $164.065. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001532023-24-000008 · wk-form4_1716416222.xml · nonDerivative · entry 1

Gangolli Julian S · CIK 0001532023 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,000

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001298711-24-000009 · wk-form4_1710203207.xml · nonDerivative · entry 14

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,612,262

F9 · kind: These sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Krish S. Krishnan. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F10 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Krish S. Krishnan.

F18 · price: The transaction was executed in multiple trades ranging from $173.6800 to $174.5000. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F12 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298711-24-000009 · wk-form4_1710203207.xml · nonDerivative · entry 13

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,613,576

F9 · kind: These sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Krish S. Krishnan. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F10 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Krish S. Krishnan.

F17 · price: The transaction was executed in multiple trades ranging from $172.5800 to $173.5500. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F12 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298711-24-000009 · wk-form4_1710203207.xml · nonDerivative · entry 12

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,616,935

F9 · kind: These sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Krish S. Krishnan. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F10 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Krish S. Krishnan.

F16 · price: The transaction was executed in multiple trades ranging from $171.5700 to $172.5500. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F12 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298711-24-000009 · wk-form4_1710203207.xml · nonDerivative · entry 11

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,619,751

F9 · kind: These sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Krish S. Krishnan. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F10 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Krish S. Krishnan.

F15 · price: The transaction was executed in multiple trades ranging from $170.5400 to $171.5100. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F12 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298711-24-000009 · wk-form4_1710203207.xml · nonDerivative · entry 10

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,627,753

F9 · kind: These sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Krish S. Krishnan. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F10 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Krish S. Krishnan.

F14 · price: The transaction was executed in multiple trades ranging from $169.5400 to $170.5300. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F12 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298711-24-000009 · wk-form4_1710203207.xml · nonDerivative · entry 9

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,632,862

F9 · kind: These sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Krish S. Krishnan. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F10 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Krish S. Krishnan.

F13 · price: The transaction was executed in multiple trades ranging from $168.4900 to $169.3300. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F12 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298711-24-000009 · wk-form4_1710203207.xml · nonDerivative · entry 8

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,635,116

F9 · kind: These sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Krish S. Krishnan. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F10 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Krish S. Krishnan.

F11 · price: The transaction was executed in multiple trades ranging from $167.4900 to $168.4800. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F12 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298711-24-000009 · wk-form4_1710203207.xml · nonDerivative · entry 7

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,550,882

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F8 · price: The transaction was executed in multiple trades ranging from $173.9000 to $174.5000. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298711-24-000009 · wk-form4_1710203207.xml · nonDerivative · entry 6

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,551,682

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F7 · price: The transaction was executed in multiple trades ranging from $172.9000 to $173.8800. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298711-24-000009 · wk-form4_1710203207.xml · nonDerivative · entry 5

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,555,269

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F6 · price: The transaction was executed in multiple trades ranging from $171.8300 to $172.8000. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298711-24-000009 · wk-form4_1710203207.xml · nonDerivative · entry 4

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,558,069

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F5 · price: The transaction was executed in multiple trades ranging from $170.7600 to $171.7500. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298711-24-000009 · wk-form4_1710203207.xml · nonDerivative · entry 3

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,563,538

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F4 · price: The transaction was executed in multiple trades ranging from $169.7600 to $170.7500. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298711-24-000009 · wk-form4_1710203207.xml · nonDerivative · entry 2

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,571,578

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F3 · price: The transaction was executed in multiple trades ranging from $168.5700 to $169.4900. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298711-24-000009 · wk-form4_1710203207.xml · nonDerivative · entry 1

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,573,224

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F2 · price: The transaction was executed in multiple trades ranging from $167.5700 to $168.5600. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298709-24-000009 · wk-form4_1710203047.xml · nonDerivative · entry 14

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,550,882

F9 · kind: These sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F10 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Suma M. Krishnan.

F18 · price: The transaction was executed in multiple trades ranging from $173.9000 to $174.5000. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F12 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298709-24-000009 · wk-form4_1710203047.xml · nonDerivative · entry 13

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,551,682

F9 · kind: These sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F10 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Suma M. Krishnan.

F17 · price: The transaction was executed in multiple trades ranging from $172.9000 to $173.8800. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F12 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298709-24-000009 · wk-form4_1710203047.xml · nonDerivative · entry 12

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,555,269

F9 · kind: These sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F10 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Suma M. Krishnan.

F16 · price: The transaction was executed in multiple trades ranging from $171.8300 to $172.8000. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F12 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298709-24-000009 · wk-form4_1710203047.xml · nonDerivative · entry 11

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,558,069

F9 · kind: These sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F10 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Suma M. Krishnan.

F15 · price: The transaction was executed in multiple trades ranging from $170.7600 to $171.7500. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F12 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298709-24-000009 · wk-form4_1710203047.xml · nonDerivative · entry 10

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,563,538

F9 · kind: These sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F10 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Suma M. Krishnan.

F14 · price: The transaction was executed in multiple trades ranging from $169.7600 to $170.7500. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F12 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298709-24-000009 · wk-form4_1710203047.xml · nonDerivative · entry 9

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,571,578

F9 · kind: These sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F10 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Suma M. Krishnan.

F13 · price: The transaction was executed in multiple trades ranging from $168.5700 to $169.4900. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F12 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298709-24-000009 · wk-form4_1710203047.xml · nonDerivative · entry 8

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,573,224

F9 · kind: These sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F10 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Suma M. Krishnan.

F11 · price: The transaction was executed in multiple trades ranging from $167.5700 to $168.5600. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F12 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298709-24-000009 · wk-form4_1710203047.xml · nonDerivative · entry 7

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,612,262

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F8 · price: The transaction was executed in multiple trades ranging from $173.6800 to $174.5000. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298709-24-000009 · wk-form4_1710203047.xml · nonDerivative · entry 6

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,613,576

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F7 · price: The transaction was executed in multiple trades ranging from $172.5800 to $173.5300. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298709-24-000009 · wk-form4_1710203047.xml · nonDerivative · entry 5

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,616,935

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F6 · price: The transaction was executed in multiple trades ranging from $171.5700 to $172.5500. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298709-24-000009 · wk-form4_1710203047.xml · nonDerivative · entry 4

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,619,751

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F5 · price: The transaction was executed in multiple trades ranging from $170.5400 to $171.5100. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298709-24-000009 · wk-form4_1710203047.xml · nonDerivative · entry 3

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,627,753

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F4 · price: The transaction was executed in multiple trades ranging from $169.5400 to $170.5300. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298709-24-000009 · wk-form4_1710203047.xml · nonDerivative · entry 2

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,632,862

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F3 · price: The transaction was executed in multiple trades ranging from $168.4900 to $169.3300. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298709-24-000009 · wk-form4_1710203047.xml · nonDerivative · entry 1

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,635,116

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on September 11, 2023, and will terminate on September 11, 2024, and contemplates sales of 25,000 shares per quarter with a limit price of $100.00 per share.

F2 · price: The transaction was executed in multiple trades ranging from $167.4900 to $168.4800. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001801385-24-000011 · wk-form4_1709342394.xml · derivative · entry 21

ROMANO KATHRYN · CIK 0001801385 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,000

Underlying: Common Stock · 15,000 shares

Expires not disclosed

F15 · derivative.exercise_price: Each PSU represents a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement.

F16 · shares: The number of PSUs in this column represents the number of shares of common stock the Reporting Person will receive assuming achievement of all of the performance criteria set by the Company's Compensation Committee for this PSU award and full vesting.

F17 · derivative.exercise_date: If any applicable portion of the performance criteria have been achieved, the PSU award shall vest in two equal annual installments (February 28, 2025 and February 28, 2026).

F18 · derivative.expiration_date: If some or all of the performance criteria are not achieved, the applicable portion of the PSU award will be forfeited.

SEC source: 0001298711-24-000006 · wk-form4_1709341989.xml · derivative · entry 8

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Common Stock · 45,000 shares

Expires not disclosed

F11 · derivative.exercise_price: Each PSU represents a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement.

F12 · shares: The number of PSUs in this column represents the number of shares of common stock the Reporting Person will receive assuming achievement of all of the performance criteria set by the Company's Compensation Committee for this PSU award and full vesting of this PSU award.

F13 · derivative.exercise_date: If any applicable portion of the performance criteria have been achieved, the PSU award shall vest in two equal annual installments (February 28, 2025 and February 28, 2026).

F14 · derivative.expiration_date: If some or all of the performance criteria are not achieved, the applicable portion of the PSU award will be forfeited.

SEC source: 0001298709-24-000006 · wk-form4_1709341735.xml · derivative · entry 9

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 52,500

Underlying: Common Stock · 52,500 shares

Expires not disclosed

F14 · derivative.exercise_price: Each PSU represents a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement.

F15 · shares: The number of PSUs in this column represents the number of shares of common stock the Reporting Person will receive assuming achievement of all of the performance criteria set by the Company's Compensation Committee for this PSU award and full vesting of this PSU award.

F16 · derivative.exercise_date: If any applicable portion of the performance criteria have been achieved, the PSU award shall vest in two equal annual installments (February 28, 2025 and February 28, 2026).

F17 · derivative.expiration_date: If some or all of the performance criteria are not achieved, the applicable portion of the PSU award will be forfeited.

SEC source: 0001298709-24-000006 · wk-form4_1709341735.xml · derivative · entry 8

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 35,000

Underlying: Common Stock · 35,000 shares

Expires not disclosed

F11 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date.

F12 · shares: The number of RSUs in this column represents the number of shares of common stock the Reporting Person will receive assuming the Reporting Person's continued service to the Company on all applicable vesting dates.

F13 · derivative.exercise_date: The RSUs vest in four equal annual installments with the first installment vesting on February 28, 2025.

F13 · derivative.expiration_date: The RSUs vest in four equal annual installments with the first installment vesting on February 28, 2025.

SEC source: 0001801385-24-000011 · wk-form4_1709342394.xml · derivative · entry 20

ROMANO KATHRYN · CIK 0001801385 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 5,000

Underlying: Common Stock · 5,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F13 · derivative.exercise_price: Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2023, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. All of the performance criteria were achieved and one-half of the PSUs granted, or 5,000 PSUs, vested on February 28, 2024.

F14 · derivative.exercise_date: The Performance Stock Units vest ratably over a two-year period with the first installment vesting on February 28, 2024.

F14 · derivative.expiration_date: The Performance Stock Units vest ratably over a two-year period with the first installment vesting on February 28, 2024.

SEC source: 0001801385-24-000011 · wk-form4_1709342394.xml · derivative · entry 19

ROMANO KATHRYN · CIK 0001801385 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 5,000 shares

Expires 2032-02-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on August 29, 2023 and will terminate on June 28, 2024 and contemplates option exercises and sales of 5,000 shares with a limit price of $150.00 per share.

F12 · derivative.exercise_date: 50,000 options were granted that vest in four equal annual installments with the first installment vesting on February 28, 2023.

SEC source: 0001801385-24-000011 · wk-form4_1709342394.xml · nonDerivative · entry 18

ROMANO KATHRYN · CIK 0001801385 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,622

F10 · shares: Represents the number of shares of common stock surrendered to the Company for tax withholding upon the vesting of 5,000 PSUs on February 28, 2024.

F11 · price: The closing price on February 28, 2024 of the Company's common stock on NASDAQ.

SEC source: 0001801385-24-000011 · wk-form4_1709342394.xml · nonDerivative · entry 17

ROMANO KATHRYN · CIK 0001801385 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 17,936

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F9 · shares: 10,000 performance stock units ("PSUs") were granted on February 28, 2023. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31 2023, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. All of the performance criteria were achieved and one-half of the PSUs granted, or 5,000 PSUs, vested on February 28, 2024.

SEC source: 0001801385-24-000011 · wk-form4_1709342394.xml · nonDerivative · entry 16

ROMANO KATHRYN · CIK 0001801385 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,936

F1 · kind: The option exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on August 29, 2023 and will terminate on June 28, 2024 and contemplates option exercises and sales of 5,000 shares with a limit price of $150.00 per share.

SEC source: 0001801385-24-000011 · wk-form4_1709342394.xml · nonDerivative · entry 15

ROMANO KATHRYN · CIK 0001801385 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 13,026

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on August 29, 2023 and will terminate on June 28, 2024 and contemplates option exercises and sales of 5,000 shares with a limit price of $150.00 per share.

SEC source: 0001801385-24-000011 · wk-form4_1709342394.xml · nonDerivative · entry 14

ROMANO KATHRYN · CIK 0001801385 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,936

F1 · kind: The option exercise and sale reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on August 29, 2023 and will terminate on June 28, 2024 and contemplates option exercises and sales of 5,000 shares with a limit price of $150.00 per share.

F8 · price: The transaction was executed in multiple trades ranging from $169.790 to $170.000. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.