KRYS

SEC source: 0001298709-25-000004 · wk-form4_1741903456.xml · nonDerivative · entry 12

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,463,711

F8 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F14 · price: The transaction was executed in multiple trades ranging from $179.33 to $179.70. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F10 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298709-25-000004 · wk-form4_1741903456.xml · nonDerivative · entry 11

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,465,042

F8 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F13 · price: The transaction was executed in multiple trades ranging from $178.31 to $179.26. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F10 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298709-25-000004 · wk-form4_1741903456.xml · nonDerivative · entry 10

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,471,556

F8 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F12 · price: The transaction was executed in multiple trades ranging from $177.30 to $178.28. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F10 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298709-25-000004 · wk-form4_1741903456.xml · nonDerivative · entry 9

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,482,493

F8 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F11 · price: The transaction was executed in multiple trades ranging from $176.30 to $177.29. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F10 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298709-25-000004 · wk-form4_1741903456.xml · nonDerivative · entry 8

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Indirect · By Spouse

Disclosed balance after: 1,487,072

F8 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person's spouse, Suma M. Krishnan, on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F9 · price: The transaction was executed in multiple trades ranging from $175.30 to $176.28. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

F10 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298709-25-000004 · wk-form4_1741903456.xml · nonDerivative · entry 5

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,533,056

F1 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F6 · price: The transaction was executed in multiple trades ranging from $179.29 to $179.74. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298709-25-000004 · wk-form4_1741903456.xml · nonDerivative · entry 4

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,534,312

F1 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F5 · price: The transaction was executed in multiple trades ranging from $178.29 to $179.27. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298709-25-000004 · wk-form4_1741903456.xml · nonDerivative · entry 3

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,541,081

F1 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F4 · price: The transaction was executed in multiple trades ranging from $177.28 to $178.25. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298709-25-000004 · wk-form4_1741903456.xml · nonDerivative · entry 2

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,552,012

F1 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F3 · price: The transaction was executed in multiple trades ranging from $176.28 to $177.25. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001298709-25-000004 · wk-form4_1741903456.xml · nonDerivative · entry 1

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 1,556,956

F1 · shares: The sales reported were made pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 13, 2024. The Rule 10b5-1 trading plan started on September 12, 2024 and will terminate on September 13, 2025 and contemplates quarterly sales of 25,000 shares of common stock with a limit price of $150.00 per share.

F2 · price: The transaction was executed in multiple trades ranging from $175.23 to $176.18. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer, or a security holder of the issuer, full information regarding the number of shares sold at each separate price within the range set forth herein.

SEC source: 0001801385-25-000002 · wk-form4_1740787298.xml · derivative · entry 10

ROMANO KATHRYN · CIK 0001801385 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 2,200

Underlying: Common Stock · 2,200 shares

Expires not disclosed

F11 · derivative.exercise_price: Each Restricted Stock Unit ("RSU") represents a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date.

F12 · shares: The number of RSUs in this column represents the number of shares of common stock the Reporting Person will receive assuming the Reporting Person's continued service to the Company on all applicable vesting dates.

F13 · derivative.exercise_date: The RSUs vest in four equal annual installments with the first installment vesting on February 28, 2026.

F13 · derivative.expiration_date: The RSUs vest in four equal annual installments with the first installment vesting on February 28, 2026.

SEC source: 0001801385-25-000002 · wk-form4_1740787298.xml · derivative · entry 9

ROMANO KATHRYN · CIK 0001801385 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2035-02-28

F10 · derivative.exercise_date: The option vests in four equal annual installments beginning on February 28, 2026.

SEC source: 0001801385-25-000002 · wk-form4_1740787298.xml · derivative · entry 8

ROMANO KATHRYN · CIK 0001801385 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 7,500

Underlying: Common Stock · 7,500 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · derivative.exercise_price: 15,000 PSUs were granted on February 29, 2024. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 7,500 PSUs, vested on February 28, 2025.

F8 · derivative.exercise_date: 15,000 PSUs were granted on February 29, 2024. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 7,500 PSUs, vested on February 28, 2025.

F8 · derivative.expiration_date: 15,000 PSUs were granted on February 29, 2024. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 7,500 PSUs, vested on February 28, 2025.

SEC source: 0001801385-25-000002 · wk-form4_1740787298.xml · derivative · entry 7

ROMANO KATHRYN · CIK 0001801385 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 5,000 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: 10,000 performance stock units ("PSUs") were granted on February 28, 2023. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31 2023, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vested ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 5,000 PSUs, vested on February 28, 2024, and the remaining 5,000 PSUs vested on February 28, 2025.

F5 · derivative.exercise_date: 10,000 performance stock units ("PSUs") were granted on February 28, 2023. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31 2023, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vested ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 5,000 PSUs, vested on February 28, 2024, and the remaining 5,000 PSUs vested on February 28, 2025.

F5 · derivative.expiration_date: 10,000 performance stock units ("PSUs") were granted on February 28, 2023. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31 2023, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vested ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 5,000 PSUs, vested on February 28, 2024, and the remaining 5,000 PSUs vested on February 28, 2025.

SEC source: 0001801385-25-000002 · wk-form4_1740787298.xml · nonDerivative · entry 6

ROMANO KATHRYN · CIK 0001801385 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 19,318

F9 · shares: Represents the number of shares of common stock surrendered to the Company for tax withholding upon the vesting of 7,500 PSUs on February 28, 2025.

F7 · price: The closing price on February 28, 2025 of the Company's common stock on the Nasdaq Global Select Market.

SEC source: 0001801385-25-000002 · wk-form4_1740787298.xml · nonDerivative · entry 5

ROMANO KATHRYN · CIK 0001801385 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 22,789

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · shares: 15,000 PSUs were granted on February 29, 2024. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 7,500 PSUs, vested on February 28, 2025.

SEC source: 0001801385-25-000002 · wk-form4_1740787298.xml · nonDerivative · entry 4

ROMANO KATHRYN · CIK 0001801385 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 15,289

F6 · shares: Represents the number of shares of common stock surrendered to the Company for tax withholding upon the vesting of 5,000 PSUs on February 28, 2025.

F7 · price: The closing price on February 28, 2025 of the Company's common stock on the Nasdaq Global Select Market.

SEC source: 0001801385-25-000002 · wk-form4_1740787298.xml · nonDerivative · entry 3

ROMANO KATHRYN · CIK 0001801385 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 17,604

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · shares: 10,000 performance stock units ("PSUs") were granted on February 28, 2023. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31 2023, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vested ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 5,000 PSUs, vested on February 28, 2024, and the remaining 5,000 PSUs vested on February 28, 2025.

SEC source: 0001298711-25-000002 · wk-form4_1740787199.xml · derivative · entry 18

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,000

Underlying: Common Stock · 16,000 shares

Expires not disclosed

F19 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date.

F20 · shares: The number of RSUs in this column represents the number of shares of common stock the Reporting Person will receive assuming the Reporting Person's continued service to the Company on all applicable vesting dates.

F21 · derivative.exercise_date: The RSUs vest in four equal annual installments with the first installment vesting on February 28, 2026.

F21 · derivative.expiration_date: The RSUs vest in four equal annual installments with the first installment vesting on February 28, 2026.

SEC source: 0001298711-25-000002 · wk-form4_1740787199.xml · derivative · entry 17

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2035-02-28

F18 · derivative.exercise_date: The option vests in four equal annual installments beginning on February 28, 2026.

SEC source: 0001298711-25-000002 · wk-form4_1740787199.xml · derivative · entry 16

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,500

Underlying: Common Stock · 22,500 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_price: 45,000 performance stock units ("PSUs") were granted on February 29, 2024. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 22,500 PSUs, vested on February 28, 2025.

F6 · derivative.exercise_date: 45,000 performance stock units ("PSUs") were granted on February 29, 2024. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 22,500 PSUs, vested on February 28, 2025.

F6 · derivative.expiration_date: 45,000 performance stock units ("PSUs") were granted on February 29, 2024. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 22,500 PSUs, vested on February 28, 2025.

SEC source: 0001298711-25-000002 · wk-form4_1740787199.xml · derivative · entry 15

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 7,500 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: 15,000 performance stock units ("PSUs") were granted on February 28, 2023. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2023, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vested ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 7,500 PSUs, vested on February 28, 2024, and the remaining 7,500 PSUs vested on February 28, 2025.

F3 · derivative.exercise_date: 15,000 performance stock units ("PSUs") were granted on February 28, 2023. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2023, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vested ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 7,500 PSUs, vested on February 28, 2024, and the remaining 7,500 PSUs vested on February 28, 2025.

F3 · derivative.expiration_date: 15,000 performance stock units ("PSUs") were granted on February 28, 2023. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2023, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vested ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 7,500 PSUs, vested on February 28, 2024, and the remaining 7,500 PSUs vested on February 28, 2025.

SEC source: 0001298711-25-000002 · wk-form4_1740787199.xml · nonDerivative · entry 11

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse

Disclosed balance after: 1,562,777

F9 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Krish S. Krishnan.

F15 · shares: Represents number of shares of common stock surrendered to the Company for tax withholding by the Reporting Person's spouse, Krish S. Krishnan, upon the vesting of 26,250 PSUs on February 28, 2025.

F5 · price: The closing price on February 28, 2025 of the Company's common stock on the Nasdaq Global Select Market.

F10 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298711-25-000002 · wk-form4_1740787199.xml · nonDerivative · entry 10

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse

Disclosed balance after: 1,574,926

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F9 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Krish S. Krishnan.

F14 · shares: 52,500 PSUs were granted on February 29, 2024, to the Reporting Person's spouse, Krish S. Krishnan. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's spouse continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 26,250 PSUs, vested on February 28, 2025.

F10 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298711-25-000002 · wk-form4_1740787199.xml · nonDerivative · entry 9

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse

Disclosed balance after: 1,548,676

F9 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Krish S. Krishnan.

F13 · shares: Represents number of shares of common stock surrendered to the Company for tax withholding by the Reporting Person's spouse, Krish S. Krishnan, upon the vesting of 8,750 RSUs on February 28, 2025.

F5 · price: The closing price on February 28, 2025 of the Company's common stock on the Nasdaq Global Select Market.

F10 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298711-25-000002 · wk-form4_1740787199.xml · nonDerivative · entry 8

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse

Disclosed balance after: 1,552,726

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F9 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Krish S. Krishnan.

F12 · shares: 35,000 restricted stock units ("RSUs") were granted on February 29, 2024, to the Reporting Person's spouse, Krish S. Krishnan. Each RSU represented a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's spouse continued service to the Company on each applicable vesting date. The RSUs vest ratably over a four-year period with the first installment, or 8,750 RSUs, vesting on February 28, 2025.

F10 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298711-25-000002 · wk-form4_1740787199.xml · nonDerivative · entry 7

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse

Disclosed balance after: 1,543,976

F9 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Krish S. Krishnan.

F11 · shares: Represents number of shares of common stock surrendered to the Company for tax withholding by the Reporting Person's spouse, Krish S. Krishnan, upon the vesting of 12,500 PSUs on February 28, 2025.

F5 · price: The closing price on February 28, 2025 of the Company's common stock on the Nasdaq Global Select Market.

F10 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298711-25-000002 · wk-form4_1740787199.xml · nonDerivative · entry 6

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse

Disclosed balance after: 1,549,762

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · shares: 25,000 PSUs were granted on February 28, 2023, to the Reporting Person's spouse, Krish S. Krishnan. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2023, as approved by the Company's Compensation Committee, and the Reporting Person's spouse continued service to the Company on each applicable vesting date following such achievement. The PSUs vested ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 12,500 PSUs, vested on February 28, 2024, and the remaining 12,500 PSUs vested on February 28, 2025.

F9 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Krish S. Krishnan.

F10 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298711-25-000002 · wk-form4_1740787199.xml · nonDerivative · entry 5

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,488,711

F7 · shares: Represents the number of shares of common stock surrendered to the Company for tax withholding upon the vesting of 22,500 PSUs on February 28, 2025.

F5 · price: The closing price on February 28, 2025 of the Company's common stock on the Nasdaq Global Select Market.

SEC source: 0001298711-25-000002 · wk-form4_1740787199.xml · nonDerivative · entry 4

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,499,125

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · shares: 45,000 performance stock units ("PSUs") were granted on February 29, 2024. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 22,500 PSUs, vested on February 28, 2025.

SEC source: 0001298711-25-000002 · wk-form4_1740787199.xml · nonDerivative · entry 3

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,476,625

F4 · shares: Represents the number of shares of common stock surrendered to the Company for tax withholding upon the vesting of 7,500 PSUs on February 28, 2025.

F5 · price: The closing price on February 28, 2025 of the Company's common stock on the Nasdaq Global Select Market.

SEC source: 0001298711-25-000002 · wk-form4_1740787199.xml · nonDerivative · entry 2

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,480,096

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · shares: 15,000 performance stock units ("PSUs") were granted on February 28, 2023. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2023, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vested ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 7,500 PSUs, vested on February 28, 2024, and the remaining 7,500 PSUs vested on February 28, 2025.

SEC source: 0001298709-25-000002 · wk-form4_1740787086.xml · derivative · entry 19

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,900

Underlying: Common Stock · 22,900 shares

Expires not disclosed

F19 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date.

F20 · shares: The number of RSUs in this column represents the number of shares of common stock the Reporting Person will receive assuming the Reporting Person's continued service to the Company on all applicable vesting dates.

F21 · derivative.exercise_date: The RSUs vest in four equal annual installments with the first installment vesting on February 28, 2026.

F21 · derivative.expiration_date: The RSUs vest in four equal annual installments with the first installment vesting on February 28, 2026.

SEC source: 0001298709-25-000002 · wk-form4_1740787086.xml · derivative · entry 18

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,300

Underlying: Common Stock · 39,300 shares

Expires 2035-02-28

F18 · derivative.exercise_date: The option vests in four equal annual installments beginning on February 28, 2026.

SEC source: 0001298709-25-000002 · wk-form4_1740787086.xml · derivative · entry 17

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,250

Underlying: Common Stock · 26,250 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · derivative.exercise_price: 52,500 performance stock units ("PSUs") were granted on February 29, 2024. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 26,250 PSUs, vested on February 28, 2025.

F8 · derivative.exercise_date: 52,500 performance stock units ("PSUs") were granted on February 29, 2024. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 26,250 PSUs, vested on February 28, 2025.

F8 · derivative.expiration_date: 52,500 performance stock units ("PSUs") were granted on February 29, 2024. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 26,250 PSUs, vested on February 28, 2025.

SEC source: 0001298709-25-000002 · wk-form4_1740787086.xml · derivative · entry 16

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,250

Underlying: Common Stock · 8,750 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · derivative.exercise_price: 35,000 restricted stock units ("RSUs") were granted on February 29, 2024. Each RSU represented a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date. The RSUs vest ratably over a four-year period with the first installment, or 8,750 RSUs, vesting on February 28, 2025.

F6 · derivative.exercise_date: 35,000 restricted stock units ("RSUs") were granted on February 29, 2024. Each RSU represented a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date. The RSUs vest ratably over a four-year period with the first installment, or 8,750 RSUs, vesting on February 28, 2025.

F6 · derivative.expiration_date: 35,000 restricted stock units ("RSUs") were granted on February 29, 2024. Each RSU represented a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date. The RSUs vest ratably over a four-year period with the first installment, or 8,750 RSUs, vesting on February 28, 2025.

SEC source: 0001298709-25-000002 · wk-form4_1740787086.xml · derivative · entry 15

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 12,500 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: 25,000 performance stock units ("PSUs") were granted on February 28, 2023. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2023, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 12,500 PSUs, vested on February 28, 2024, and the other 12,500 PSUs vested on February 28, 2025.

F3 · derivative.exercise_date: 25,000 performance stock units ("PSUs") were granted on February 28, 2023. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2023, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 12,500 PSUs, vested on February 28, 2024, and the other 12,500 PSUs vested on February 28, 2025.

F3 · derivative.expiration_date: 25,000 performance stock units ("PSUs") were granted on February 28, 2023. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2023, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 12,500 PSUs, vested on February 28, 2024, and the other 12,500 PSUs vested on February 28, 2025.

SEC source: 0001298709-25-000002 · wk-form4_1740787086.xml · nonDerivative · entry 11

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse

Disclosed balance after: 1,491,997

F11 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Suma M. Krishnan.

F15 · shares: Represents number of shares of common stock surrendered to the Company for tax withholding by the Reporting Person's spouse, Suma M. Krishnan, upon the vesting of 22,500 PSUs on February 28, 2025.

F5 · price: The closing price on February 28, 2025 of the Company's common stock on the Nasdaq Global Select Market.

F12 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298709-25-000002 · wk-form4_1740787086.xml · nonDerivative · entry 10

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse

Disclosed balance after: 1,502,411

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F11 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Suma M. Krishnan.

F14 · shares: 45,000 PSUs were granted on February 29, 2024, to the Reporting Person's spouse, Suma M. Krishnan. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's spouse continued service to the Company on each applicable vesting date following such achievement. All of the performance criteria were achieved and one-half of the PSUs granted, or 22,500 PSUs, vested on February 28, 2025.

F12 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298709-25-000002 · wk-form4_1740787086.xml · nonDerivative · entry 9

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse

Disclosed balance after: 1,479,911

F11 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Suma M. Krishnan.

F13 · shares: Represents number of shares of common stock surrendered to the Company for tax withholding by the Reporting Person's spouse, Suma M. Krishnan, upon the vesting of 7,500 PSUs on February 28, 2025.

F5 · price: The closing price on February 28, 2025 of the Company's common stock on the Nasdaq Global Select Market.

F12 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298709-25-000002 · wk-form4_1740787086.xml · nonDerivative · entry 8

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse

Disclosed balance after: 1,483,382

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F10 · shares: 15,000 PSUs were granted on February 28, 2023, to the Reporting Person's spouse, Suma M. Krishnan. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2023, as approved by the Company's Compensation Committee, and the Reporting Person's spouse continued service to the Company on each applicable vesting date following such achievement. All of the performance criteria were achieved and one-half of the PSUs granted, or 7,500 PSUs, vested on February 28, 2024, and the other 7,500 PSUs vested on February 28, 2025.

F11 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Suma M. Krishnan.

F12 · ownership.nature: Directly beneficially owned by Suma M. Krishnan, the spouse of the Reporting Person.

SEC source: 0001298709-25-000002 · wk-form4_1740787086.xml · nonDerivative · entry 7

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,558,056

F9 · shares: Represents the number of shares of common stock surrendered to the Company for tax withholding upon the vesting of 26,250 PSUs on February 28, 2025.

F5 · price: The closing price on February 28, 2025 of the Company's common stock on the Nasdaq Global Select Market.

SEC source: 0001298709-25-000002 · wk-form4_1740787086.xml · nonDerivative · entry 6

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,570,205

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F8 · shares: 52,500 performance stock units ("PSUs") were granted on February 29, 2024. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2024, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 26,250 PSUs, vested on February 28, 2025.

SEC source: 0001298709-25-000002 · wk-form4_1740787086.xml · nonDerivative · entry 5

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,543,955

F7 · shares: Represents the number of shares of common stock surrendered to the Company for tax withholding upon the vesting of 8,750 RSUs on February 28, 2025.

F5 · price: The closing price on February 28, 2025 of the Company's common stock on the Nasdaq Global Select Market.

SEC source: 0001298709-25-000002 · wk-form4_1740787086.xml · nonDerivative · entry 4

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,548,005

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F6 · shares: 35,000 restricted stock units ("RSUs") were granted on February 29, 2024. Each RSU represented a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date. The RSUs vest ratably over a four-year period with the first installment, or 8,750 RSUs, vesting on February 28, 2025.

SEC source: 0001298709-25-000002 · wk-form4_1740787086.xml · nonDerivative · entry 3

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,539,255

F4 · shares: Represents the number of shares of common stock surrendered to the Company for tax withholding upon the vesting of 12,500 PSUs on February 28, 2025.

F5 · price: The closing price on February 28, 2025 of the Company's common stock on the Nasdaq Global Select Market.

SEC source: 0001298709-25-000002 · wk-form4_1740787086.xml · nonDerivative · entry 2

Krishnan Krish S · CIK 0001298709 · Director · President and CEO · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,545,041

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · shares: 25,000 performance stock units ("PSUs") were granted on February 28, 2023. Each PSU represented a contingent right to receive one share of the Company's common stock, subject to the achievement of certain performance criteria during the year ended December 31, 2023, as approved by the Company's Compensation Committee, and the Reporting Person's continued service to the Company on each applicable vesting date following such achievement. The PSUs vest ratably over a two-year period. All of the performance criteria were achieved and one-half of the PSUs granted, or 12,500 PSUs, vested on February 28, 2024, and the other 12,500 PSUs vested on February 28, 2025.

SEC source: 0001801385-25-000002 · wk-form4_1740787298.xml · nonDerivative · entry 2

ROMANO KATHRYN · CIK 0001801385 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,604

F3 · shares: The sale of the shares of the Company's common stock reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person. The Rule 10b5-1 trading plan started on November 18, 2024 and will terminate on the earlier of August 20, 2025 or the date all trades are executed or expire under the Rule 10b5-1 trading plan.

F4 · price: The transaction was executed in multiple lots at the same price, $175.22.

SEC source: 0001801385-25-000002 · wk-form4_1740787298.xml · nonDerivative · entry 1

ROMANO KATHRYN · CIK 0001801385 · Chief Accounting Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 13,354

F1 · shares: Represents the number of shares of common stock surrendered to the Company for tax withholding upon the vesting of 4,900 shares of restricted stock on February 26, 2025. 19,600 Restricted Stock Awards ("RSAs) were granted on February 26, 2021, to the Reporting Person. Each RSA represented a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's continued service to the Company on each applicable vesting date. The RSAs vested in four equal annual installments beginning on February 26, 2022.

F2 · price: The closing price on February 26, 2025 of the Company's common stock on the Nasdaq Global Select Market.

SEC source: 0001298711-25-000002 · wk-form4_1740787199.xml · nonDerivative · entry 12

Krishnan Suma · CIK 0001298711 · Director · President, R&D · 10% owner

10b5-1 filing: No plan indicated

Ownership: Indirect · By Spouse

Disclosed balance after: 1,558,056

F9 · shares: These same shares are also being reported on a Form 4 by the Reporting Person's spouse, Krish S. Krishnan.

F16 · shares: Represents the number of shares of common stock surrendered to the Company for tax withholding by the Reporting Person's spouse, Krish S. Krishnan, upon the vesting of 10,200 shares of restricted stock on February 26, 2025. 40,800 RSAs were granted on February 26, 2021, to the Reporting Person's spouse, Krish S. Krishnan. Each RSA represented a contingent right to receive one share of the Company's common stock, subject to the Reporting Person's spouse continued service to the Company on each applicable vesting date. The RSAs vested in four equal annual installments beginning on February 26, 2022.

F10 · ownership.nature: Directly beneficially owned by Krish S. Krishnan, the spouse of the Reporting Person.