KRRO

SEC source: 0001127602-20-026721 · form4.xml · nonDerivative · entry 2

Loose Christopher R. · CIK 0001785299 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 103,782

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 11, 2020.

F2 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $20.00 to $20.10. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-026721 · form4.xml · nonDerivative · entry 1

Loose Christopher R. · CIK 0001785299 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 111,782

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 11, 2020.

SEC source: 0001127602-20-026567 · form4.xml · nonDerivative · entry 3

Loose Christopher R. · CIK 0001785299 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 119,782

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 11, 2020.

SEC source: 0001127602-20-026567 · form4.xml · nonDerivative · entry 2

Loose Christopher R. · CIK 0001785299 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 127,782

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 11, 2020.

SEC source: 0001127602-20-026567 · form4.xml · nonDerivative · entry 1

Loose Christopher R. · CIK 0001785299 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 135,782

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 11, 2020.

SEC source: 0001127602-20-026530 · form4.xml · nonDerivative · entry 2

Lucchino David L. · CIK 0001785288 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 355,228

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 20, 2019.

F3 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $19.29 to $19.94. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-026530 · form4.xml · nonDerivative · entry 1

Lucchino David L. · CIK 0001785288 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 360,106

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 20, 2019.

F2 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $18.28 to $19.25. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-025734 · form4.xml · derivative · entry 1

FELDMANN CYNTHIA L · CIK 0001264554 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,693

Underlying: Common Stock · 29,693 shares

Expires 2030-09-22

F1 · derivative.exercise_date: The option vests and becomes exercisable in equal monthly installments over a three year period commencing on October 23, 2020, and will be fully vested and exercisable on September 23, 2023.

SEC source: 0001127602-20-025709 · form4.xml · nonDerivative · entry 3

Loose Christopher R. · CIK 0001785299 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 143,782

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 10, 2019.

SEC source: 0001127602-20-025709 · form4.xml · nonDerivative · entry 2

Loose Christopher R. · CIK 0001785299 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 143,806

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 10, 2019.

F3 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $21.25 to $22.19. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-025709 · form4.xml · nonDerivative · entry 1

Loose Christopher R. · CIK 0001785299 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 146,412

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 10, 2019.

F2 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $20.15 to $20.96. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-024908 · form4.xml · nonDerivative · entry 2

Loose Christopher R. · CIK 0001785299 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 148,282

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 10, 2019.

F3 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $19.16 to $19.39. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-024908 · form4.xml · nonDerivative · entry 1

Loose Christopher R. · CIK 0001785299 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 149,058

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 10, 2019.

F2 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $18.14 to $19.14. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-024702 · form4.xml · nonDerivative · entry 2

Lucchino David L. · CIK 0001785288 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 370,944

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 20, 2019.

F3 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $18.78 to $19.225. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-024702 · form4.xml · nonDerivative · entry 1

Lucchino David L. · CIK 0001785288 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 374,530

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 20, 2019.

F2 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $17.75 to $18.71. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-023991 · form4.xml · nonDerivative · entry 1

Loose Christopher R. · CIK 0001785299 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 152,782

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 10, 2019.

F2 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $22.77 to $23.24. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-023081 · form4.xml · nonDerivative · entry 2

Loose Christopher R. · CIK 0001785299 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 157,282

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 10, 2019.

F3 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $21.85 to $21.95. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-023081 · form4.xml · nonDerivative · entry 1

Loose Christopher R. · CIK 0001785299 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 157,340

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 10, 2019.

F2 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $20.72 to $21.66. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-022915 · form4.xml · nonDerivative · entry 1

Lucchino David L. · CIK 0001785288 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 386,658

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 20, 2019.

F2 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $21.31 to $21.99. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-022045 · form4.xml · nonDerivative · entry 1

Loose Christopher R. · CIK 0001785299 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 161,782

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 10, 2019.

F2 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $21.31 to $21.70. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-022001 · form4.xml · nonDerivative · entry 1

MARCUS JOEL S · CIK 0001216955 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · Alexandria Venture Investments, LLC

Disclosed balance after: 1,011,730

F1 · shares: On July 17, 2020 the Issuer entered into a definitive securities purchase agreement with certain institutional investors (the "Private Placement"), which closed on July 20, 2020. The Private Placement consisted of 2,350,108 shares of common stock at a price of $18.00 per share The 55,555 shares of common stock reported herein were acquired pursuant to the Private Placement.

F2 · ownership.nature: Represents securities held of record by Alexandria Venture Investments, LLC ("Alexandria"). Alexandria Real Estate Equities, Inc. is the managing member of Alexandria. Each of Alexandria and Alexandria Real Estate Equities, Inc. has shared voting and investment power with respect to the shares owned by Alexandria. The reporting person is the Executive Chairman of Alexandria Real Estate Equities, Inc. and may therefore be deemed to have voting and investment power with respect to the shares owned by Alexandria. Each of the reporting person and Alexandria Real Estate Equities, Inc. disclaims beneficial ownership of such shares except to the extent of any pecuniary interest therein.

SEC source: 0000899243-20-020203 · doc4a.xml · nonDerivative · entry 1

MARCUS JOEL S · CIK 0001216955 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · Alexandria Venture Investments, LLC

Disclosed balance after: 1,011,730

F1 · kind: This amendment is being filed to correct the transaction code previously reported on the Reporting Person's Form 4 filed on July 22, 2020.

F2 · shares: On July 17, 2020 the Issuer entered into a definitive securities purchase agreement with certain institutional investors (the "Private Placement"), which closed on July 20, 2020. The Private Placement consisted of 2,350,108 shares of common stock at a price of $18.00 per share The 55,555 shares of common stock reported herein were acquired pursuant to the Private Placement.

F3 · ownership.nature: Represents securities held of record by Alexandria Venture Investments, LLC ("Alexandria"). Alexandria Real Estate Equities, Inc. is the managing member of Alexandria. Each of Alexandria and Alexandria Real Estate Equities, Inc. has shared voting and investment power with respect to the shares owned by Alexandria. The reporting person is the Executive Chairman of Alexandria Real Estate Equities, Inc. and may therefore be deemed to have voting and investment power with respect to the shares owned by Alexandria. Each of the reporting person and Alexandria Real Estate Equities, Inc. disclaims beneficial ownership of such shares except to the extent of any pecuniary interest therein.

SEC source: 0000899243-20-018925 · doc4.xml · nonDerivative · entry 2

Loose Christopher R. · CIK 0001785299 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 166,282

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 10, 2019.

F3 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $22.92 to $23.02. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0000899243-20-018925 · doc4.xml · nonDerivative · entry 1

Loose Christopher R. · CIK 0001785299 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 167,061

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 10, 2019.

F2 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $21.87 to $22.80. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-020974 · form4.xml · nonDerivative · entry 1

Lucchino David L. · CIK 0001785288 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 402,372

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 20, 2019.

F2 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $22.05 to $23.01. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-020363 · form4.xml · nonDerivative · entry 1

Loose Christopher R. · CIK 0001785299 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 170,782

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 10, 2019.

F2 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $22.33 to $23.12. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-019479 · form4.xml · derivative · entry 1

BARBERICH TIMOTHY J · CIK 0001120355 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,846

Underlying: Common Stock · 14,846 shares

Expires 2030-06-10

F1 · derivative.exercise_date: The option vests in full on the earlier of June 11, 2021 or the day immediately prior to the company's 2021 annual meeting of shareholders.

SEC source: 0001127602-20-019478 · form4.xml · derivative · entry 1

COHEN MARC A · CIK 0001132945 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,846

Underlying: Common Stock · 14,846 shares

Expires 2030-06-10

F1 · derivative.exercise_date: The option vests in full on the earlier of June 11, 2021 or the day immediately prior to the company's 2021 annual meeting of shareholders.

SEC source: 0001127602-20-019480 · form4.xml · derivative · entry 1

LANGER ROBERT · CIK 0001239757 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,846

Underlying: Common Stock · 14,846 shares

Expires 2030-06-10

F1 · derivative.exercise_date: The option vests in full on the earlier of June 11, 2021 or the day immediately prior to the company's 2021 annual meeting of shareholders.

SEC source: 0001127602-20-019481 · form4.xml · derivative · entry 1

MARCUS JOEL S · CIK 0001216955 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,846

Underlying: Common Stock · 14,846 shares

Expires 2030-06-10

F1 · derivative.exercise_date: The option vests in full on the earlier of June 11, 2021 or the day immediately prior to the company's 2021 annual meeting of shareholders

SEC source: 0001127602-20-019477 · form4.xml · derivative · entry 1

Huang Michael · CIK 0001787161 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,846

Underlying: Common Stock · 14,846 shares

Expires 2030-06-10

F1 · derivative.exercise_date: The option vests in full on the earlier of June 11, 2021 or the day immediately prior to the company's 2021 annual meeting of shareholders

SEC source: 0001127602-20-019507 · form4.xml · nonDerivative · entry 1

Loose Christopher R. · CIK 0001785299 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 175,282

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 10, 2019.

F2 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $19.72 to $20.26. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-018893 · form4.xml · derivative · entry 5

Mitrano Richard J. · CIK 0001785287 · VP Finance & Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,191

Underlying: Common Stock · 2,552 shares

Expires 2027-06-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: The option vests and becomes exercisable in equal monthly installments over a four year period commencing on February 1, 2017, and will be fully vested and exercisable on January 1, 2021.

SEC source: 0001127602-20-018893 · form4.xml · derivative · entry 4

Mitrano Richard J. · CIK 0001785287 · VP Finance & Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 124

Underlying: Common Stock · 929 shares

Expires 2026-12-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The option vests and becomes exercisable as to 25% on July 29, 2017 and in equal monthly installments thereafter and will be fully vested and exercisable on July 29, 2020.

SEC source: 0001127602-20-018893 · form4.xml · nonDerivative · entry 2

Mitrano Richard J. · CIK 0001785287 · VP Finance & Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,015

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127602-20-018893 · form4.xml · nonDerivative · entry 1

Mitrano Richard J. · CIK 0001785287 · VP Finance & Operations

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,463

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127602-20-018891 · form4.xml · nonDerivative · entry 1

Lucchino David L. · CIK 0001785288 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 418,086

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 20, 2019.

F2 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $18.15 to $19.00. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-018455 · form4.xml · nonDerivative · entry 1

Lucchino David L. · CIK 0001785288 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 421,925

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 20, 2019.

F2 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $17.46 to $18.31. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-017820 · form4.xml · nonDerivative · entry 1

MARCUS JOEL S · CIK 0001216955 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 319,700

F1 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $18.48 to $19.10. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-017400 · form4.xml · nonDerivative · entry 3

MARCUS JOEL S · CIK 0001216955 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 324,700

F3 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $18.44 to $19.31. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-017821 · form4.xml · nonDerivative · entry 2

Loose Christopher R. · CIK 0001785299 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 187,282

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 10, 2019.

F3 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $19.23 to $19.42. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-017821 · form4.xml · nonDerivative · entry 1

Loose Christopher R. · CIK 0001785299 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 189,114

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 10, 2019.

F2 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $18.23 to $19.22. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-017400 · form4.xml · nonDerivative · entry 2

MARCUS JOEL S · CIK 0001216955 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 329,700

F2 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $18.13 to $18.81. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-017400 · form4.xml · nonDerivative · entry 1

MARCUS JOEL S · CIK 0001216955 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 337,509

F1 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $18.68 to $19.65. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-016284 · form4.xml · nonDerivative · entry 1

Lucchino David L. · CIK 0001785288 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 433,800

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 20, 2019.

F2 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $18.00 to $18.60. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-015786 · form4.xml · nonDerivative · entry 2

Loose Christopher R. · CIK 0001785299 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 191,782

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 10, 2019.

F3 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $16.61 to $16.79. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-015786 · form4.xml · nonDerivative · entry 1

Loose Christopher R. · CIK 0001785299 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 192,336

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 10, 2019.

F2 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $15.59 to $16.58. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-015778 · form4.xml · nonDerivative · entry 1

Lucchino David L. · CIK 0001785288 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 444,278

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 20, 2019.

F2 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $16.00 to $16.50. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-20-015183 · form4.xml · nonDerivative · entry 1

Lucchino David L. · CIK 0001785288 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 449,517

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 20, 2019.

F2 · price: This transaction was executed in multiple trades through a broker-dealer at prices ranging from $15.06 to $15.61. The price reported in this column reflects the weighted average sales price. Upon request, the reporting person will provide to the SEC staff full information regarding the number of Shares sold at each price.

SEC source: 0001127602-21-002847 · form5.xml · nonDerivative · entry 1

Loose Christopher R. · CIK 0001785299 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,782