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Nasdaq · USD

KPTI

Karyopharm Therapeutics Inc.

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Tapewire entity
781
SEC CIK
0001503802
Parsed reports
479

Last 12 months

Inside the activity.

0 purchase rows · 20 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 202500
Dec 202500
Jan 202602
Feb 202602
Mar 202606
Apr 202601
May 202606
Jun 202600
Jul 202601
Aug 202600
Sep 202601
Oct 202601

Latest available

Insider transactions

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
October 18, 2018 Filed Oct 22, 2018 20:09 UTC
Shacham SharonPresident & CSO
SaleCommon Stock 10,000 $12.63 $126,304.00
Disclosure

SEC source: 0001209191-18-055830 · doc4.xml · nonDerivative · entry 2

Shacham Sharon · CIK 0001588438 · President & CSO

10b5-1 filing: Not disclosed

Ownership: Indirect · By Spouse

Disclosed balance after: 512,143

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the spouse of the reporting person.

F2 · price: Represents the weighted average sale price. These shares were sold in multiple transactions at prices ranging from $12.36 to $12.75, inclusive. The reporting person undertakes to provide upon request by the U.S. Securities and Exchange Commission staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price.

Read SEC document
October 18, 2018 Filed Oct 22, 2018 20:09 UTC
Shacham SharonPresident & CSO
Exercise / conversionCommon Stock 10,000 $4.75 $47,520.00
Disclosure

SEC source: 0001209191-18-055830 · doc4.xml · nonDerivative · entry 1

Shacham Sharon · CIK 0001588438 · President & CSO

10b5-1 filing: Not disclosed

Ownership: Indirect · By Spouse

Disclosed balance after: 522,143

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the spouse of the reporting person.

Read SEC document
October 08, 2018 Filed Oct 9, 2018 12:05 UTC
Kauffman MichaelDirector · Chief Executive Officer
Exercise / conversionStock Option (right to buy) · Derivative 10,736 $0.00 Strike: $0.03 $0.00
Disclosure

SEC source: 0001209191-18-054465 · doc4.xml · derivative · entry 9

Kauffman Michael · CIK 0001364719 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · By Spouse

Disclosed balance after: 52,857

Underlying: Common Stock · 10,736 shares

Expires 2020-10-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the spouse of the reporting person.

F6 · derivative.exercise_date: This option, representing a right to purchase a specified number of shares, vested as to 25% of the shares on October 22, 2011, and the remaining 75% vested in 36 equal monthly installments thereafter.

Read SEC document
October 08, 2018 Filed Oct 9, 2018 12:05 UTC
Kauffman MichaelDirector · Chief Executive Officer
Exercise / conversionStock Option (right to buy) · Derivative 1,764 $0.00 Strike: $0.03 $0.00
Disclosure

SEC source: 0001209191-18-054465 · doc4.xml · derivative · entry 8

Kauffman Michael · CIK 0001364719 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · By Spouse

Disclosed balance after: 0

Underlying: Common Stock · 1,764 shares

Expires 2020-10-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the spouse of the reporting person.

F6 · derivative.exercise_date: This option, representing a right to purchase a specified number of shares, vested as to 25% of the shares on October 22, 2011, and the remaining 75% vested in 36 equal monthly installments thereafter.

Read SEC document
October 08, 2018 Filed Oct 9, 2018 12:05 UTC
Kauffman MichaelDirector · Chief Executive Officer
SaleCommon Stock 6,000 $16.13 $96,766.80
Disclosure

SEC source: 0001209191-18-054465 · doc4.xml · nonDerivative · entry 4

Kauffman Michael · CIK 0001364719 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · By Spouse

Disclosed balance after: 713,510

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the spouse of the reporting person.

F3 · price: Represents the weighted average sale price. These shares were sold in multiple transactions at prices ranging from $16.02 to $16.26, inclusive. The reporting person undertakes to provide upon request by the U.S. Securities and Exchange Commission staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price.

Read SEC document
October 08, 2018 Filed Oct 9, 2018 12:05 UTC
Kauffman MichaelDirector · Chief Executive Officer
SaleCommon Stock 6,500 $15.39 $100,065.55
Disclosure

SEC source: 0001209191-18-054465 · doc4.xml · nonDerivative · entry 3

Kauffman Michael · CIK 0001364719 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · By Spouse

Disclosed balance after: 719,510

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the spouse of the reporting person.

F2 · price: Represents the weighted average sale price. These shares were sold in multiple transactions at prices ranging from $15.00 to $15.99, inclusive. The reporting person undertakes to provide upon request by the U.S. Securities and Exchange Commission staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price.

Read SEC document
October 08, 2018 Filed Oct 9, 2018 12:05 UTC
Kauffman MichaelDirector · Chief Executive Officer
Exercise / conversionCommon Stock 10,736 $0.03 $354.29
Disclosure

SEC source: 0001209191-18-054465 · doc4.xml · nonDerivative · entry 2

Kauffman Michael · CIK 0001364719 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · By Spouse

Disclosed balance after: 726,010

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the spouse of the reporting person.

Read SEC document
October 08, 2018 Filed Oct 9, 2018 12:05 UTC
Kauffman MichaelDirector · Chief Executive Officer
Exercise / conversionCommon Stock 1,764 $0.03 $58.21
Disclosure

SEC source: 0001209191-18-054465 · doc4.xml · nonDerivative · entry 1

Kauffman Michael · CIK 0001364719 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · By Spouse

Disclosed balance after: 715,274

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the spouse of the reporting person.

Read SEC document
October 08, 2018 Filed Oct 9, 2018 12:00 UTC
Shacham SharonPresident & CSO
Exercise / conversionStock Option (right to buy) · Derivative 10,736 $0.00 Strike: $0.03 $0.00
Disclosure

SEC source: 0001209191-18-054464 · doc4.xml · derivative · entry 9

Shacham Sharon · CIK 0001588438 · President & CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,857

Underlying: Common Stock · 10,736 shares

Expires 2020-10-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F6 · derivative.exercise_date: This option, representing a right to purchase a specified number of shares, vested as to 25% of the shares on October 22, 2011, and the remaining 75% vested in 36 equal monthly installments thereafter.

Read SEC document
October 08, 2018 Filed Oct 9, 2018 12:00 UTC
Shacham SharonPresident & CSO
Exercise / conversionStock Option (right to buy) · Derivative 1,764 $0.00 Strike: $0.03 $0.00
Disclosure

SEC source: 0001209191-18-054464 · doc4.xml · derivative · entry 8

Shacham Sharon · CIK 0001588438 · President & CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,764 shares

Expires 2020-10-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F6 · derivative.exercise_date: This option, representing a right to purchase a specified number of shares, vested as to 25% of the shares on October 22, 2011, and the remaining 75% vested in 36 equal monthly installments thereafter.

Read SEC document
October 08, 2018 Filed Oct 9, 2018 12:00 UTC
Shacham SharonPresident & CSO
SaleCommon Stock 6,000 $16.13 $96,766.80
Disclosure

SEC source: 0001209191-18-054464 · doc4.xml · nonDerivative · entry 4

Shacham Sharon · CIK 0001588438 · President & CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 713,510

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F3 · price: Represents the weighted average sale price. These shares were sold in multiple transactions at prices ranging from $16.02 to $16.26, inclusive. The reporting person undertakes to provide upon request by the U.S. Securities and Exchange Commission staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price.

Read SEC document
October 08, 2018 Filed Oct 9, 2018 12:00 UTC
Shacham SharonPresident & CSO
SaleCommon Stock 6,500 $15.39 $100,065.55
Disclosure

SEC source: 0001209191-18-054464 · doc4.xml · nonDerivative · entry 3

Shacham Sharon · CIK 0001588438 · President & CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 719,510

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: Represents the weighted average sale price. These shares were sold in multiple transactions at prices ranging from $15.00 to $15.99, inclusive. The reporting person undertakes to provide upon request by the U.S. Securities and Exchange Commission staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price.

Read SEC document
October 08, 2018 Filed Oct 9, 2018 12:00 UTC
Shacham SharonPresident & CSO
Exercise / conversionCommon Stock 10,736 $0.03 $354.29
Disclosure

SEC source: 0001209191-18-054464 · doc4.xml · nonDerivative · entry 2

Shacham Sharon · CIK 0001588438 · President & CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 726,010

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

Read SEC document
October 08, 2018 Filed Oct 9, 2018 12:00 UTC
Shacham SharonPresident & CSO
Exercise / conversionCommon Stock 1,764 $0.03 $58.21
Disclosure

SEC source: 0001209191-18-054464 · doc4.xml · nonDerivative · entry 1

Shacham Sharon · CIK 0001588438 · President & CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 715,274

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

Read SEC document
September 18, 2018 Filed Sep 18, 2018 21:23 UTC
Kauffman MichaelDirector · Chief Executive Officer
Exercise / conversionStock Option (right to buy) · Derivative 10,000 $0.00 Strike: $4.75 $0.00
Disclosure

SEC source: 0001209191-18-051510 · doc4.xml · derivative · entry 6

Kauffman Michael · CIK 0001364719 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 456,061

Underlying: Common Stock · 10,000 shares

Expires 2023-09-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F5 · derivative.exercise_date: This option, representing a right to purchase a specified number of shares, vested as to 25% of the shares on September 3, 2014, and the remaining 75% vested in 36 equal monthly installments thereafter.

Read SEC document
September 18, 2018 Filed Sep 18, 2018 21:23 UTC
Kauffman MichaelDirector · Chief Executive Officer
SaleCommon Stock 10,000 $18.26 $182,615.00
Disclosure

SEC source: 0001209191-18-051510 · doc4.xml · nonDerivative · entry 2

Kauffman Michael · CIK 0001364719 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 512,143

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: Represents the weighted average sale price. These shares were sold in multiple transactions at prices ranging from $18.02 to $18.495, inclusive. The reporting person undertakes to provide upon request by the U.S. Securities and Exchange Commission staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price.

Read SEC document
September 18, 2018 Filed Sep 18, 2018 21:23 UTC
Kauffman MichaelDirector · Chief Executive Officer
Exercise / conversionCommon Stock 10,000 $4.75 $47,520.00
Disclosure

SEC source: 0001209191-18-051510 · doc4.xml · nonDerivative · entry 1

Kauffman Michael · CIK 0001364719 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 522,143

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

Read SEC document
September 18, 2018 Filed Sep 18, 2018 21:26 UTC
Shacham SharonPresident & CSO
Exercise / conversionStock Option (right to buy) · Derivative 10,000 $0.00 Strike: $4.75 $0.00
Disclosure

SEC source: 0001209191-18-051515 · doc4.xml · derivative · entry 6

Shacham Sharon · CIK 0001588438 · President & CSO

10b5-1 filing: Not disclosed

Ownership: Indirect · By Spouse

Disclosed balance after: 456,061

Underlying: Common Stock · 10,000 shares

Expires 2023-09-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the spouse of the reporting person.

F5 · derivative.exercise_date: This option, representing a right to purchase a specified number of shares, vested as to 25% of the shares on September 3, 2014, and the remaining 75% vested in 36 equal monthly installments thereafter.

Read SEC document
September 18, 2018 Filed Sep 18, 2018 21:26 UTC
Shacham SharonPresident & CSO
SaleCommon Stock 10,000 $18.26 $182,615.00
Disclosure

SEC source: 0001209191-18-051515 · doc4.xml · nonDerivative · entry 2

Shacham Sharon · CIK 0001588438 · President & CSO

10b5-1 filing: Not disclosed

Ownership: Indirect · By Spouse

Disclosed balance after: 512,143

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the spouse of the reporting person.

F2 · price: Represents the weighted average sale price. These shares were sold in multiple transactions at prices ranging from $18.02 to $18.495, inclusive. The reporting person undertakes to provide upon request by the U.S. Securities and Exchange Commission staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price.

Read SEC document
September 18, 2018 Filed Sep 18, 2018 21:26 UTC
Shacham SharonPresident & CSO
Exercise / conversionCommon Stock 10,000 $4.75 $47,520.00
Disclosure

SEC source: 0001209191-18-051515 · doc4.xml · nonDerivative · entry 1

Shacham Sharon · CIK 0001588438 · President & CSO

10b5-1 filing: Not disclosed

Ownership: Indirect · By Spouse

Disclosed balance after: 522,143

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the spouse of the reporting person.

Read SEC document
September 10, 2018 Filed Sep 11, 2018 22:08 UTC
Primiano Christopher BrettEVP, CBO, GC & Secretary
Exercise / conversionStock Option (right to buy) · Derivative 5,000 $0.00 Strike: $10.39 $0.00
Disclosure

SEC source: 0001209191-18-050553 · doc4.xml · derivative · entry 5

Primiano Christopher Brett · CIK 0001603510 · EVP, CBO, GC & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 113,000

Underlying: Common Stock · 5,000 shares

Expires 2027-01-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F4 · derivative.exercise_date: This option, representing a right to purchase a specified number of shares, vested as to 25% of the shares on January 20, 2018, with the remaining 75% vesting in 36 equal monthly installments thereafter.

Read SEC document
September 10, 2018 Filed Sep 11, 2018 22:08 UTC
Primiano Christopher BrettEVP, CBO, GC & Secretary
Exercise / conversionStock Option (right to buy) · Derivative 5,000 $0.00 Strike: $6.54 $0.00
Disclosure

SEC source: 0001209191-18-050553 · doc4.xml · derivative · entry 4

Primiano Christopher Brett · CIK 0001603510 · EVP, CBO, GC & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,000

Underlying: Common Stock · 5,000 shares

Expires 2026-01-14

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F3 · derivative.exercise_date: This option, representing a right to purchase a specified number of shares, vested as to 25% of the shares on January 15, 2017, with the remaining 75% vesting in 36 equal monthly installments thereafter.

Read SEC document
September 10, 2018 Filed Sep 11, 2018 22:08 UTC
Primiano Christopher BrettEVP, CBO, GC & Secretary
SaleCommon Stock 10,000 $18.90 $189,046.00
Disclosure

SEC source: 0001209191-18-050553 · doc4.xml · nonDerivative · entry 3

Primiano Christopher Brett · CIK 0001603510 · EVP, CBO, GC & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,881

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: Represents the weighted average sale price. These shares were sold in multiple transactions at prices ranging from $18.27 to $19.08, inclusive. The reporting person undertakes to provide upon request by the U.S. Securities and Exchange Commission staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price.

Read SEC document
September 10, 2018 Filed Sep 11, 2018 22:08 UTC
Primiano Christopher BrettEVP, CBO, GC & Secretary
Exercise / conversionCommon Stock 5,000 $10.39 $51,950.00
Disclosure

SEC source: 0001209191-18-050553 · doc4.xml · nonDerivative · entry 2

Primiano Christopher Brett · CIK 0001603510 · EVP, CBO, GC & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,881

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

Read SEC document
September 10, 2018 Filed Sep 11, 2018 22:08 UTC
Primiano Christopher BrettEVP, CBO, GC & Secretary
Exercise / conversionCommon Stock 5,000 $6.54 $32,700.00
Disclosure

SEC source: 0001209191-18-050553 · doc4.xml · nonDerivative · entry 1

Primiano Christopher Brett · CIK 0001603510 · EVP, CBO, GC & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,881

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

Read SEC document
September 07, 2018 Filed Sep 10, 2018 20:13 UTC
Kauffman MichaelDirector · Chief Executive Officer
Exercise / conversionStock Option (right to buy) · Derivative 12,500 $0.00 Strike: $0.03 $0.00
Disclosure

SEC source: 0001209191-18-050236 · doc4.xml · derivative · entry 6

Kauffman Michael · CIK 0001364719 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · By Spouse

Disclosed balance after: 1,764

Underlying: Common Stock · 12,500 shares

Expires 2020-10-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the spouse of the reporting person.

F5 · derivative.exercise_date: This option, representing a right to purchase a specified number of shares, vested as to 25% of the shares on October 22, 2011, and the remaining 75% vested in 36 equal monthly installments thereafter.

Read SEC document
September 07, 2018 Filed Sep 10, 2018 20:13 UTC
Kauffman MichaelDirector · Chief Executive Officer
SaleCommon Stock 12,500 $19.31 $241,383.75
Disclosure

SEC source: 0001209191-18-050236 · doc4.xml · nonDerivative · entry 2

Kauffman Michael · CIK 0001364719 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · By Spouse

Disclosed balance after: 713,510

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the spouse of the reporting person.

F2 · price: Represents the weighted average sale price. These shares were sold in multiple transactions at prices ranging from $18.71 to $19.58, inclusive. The reporting person undertakes to provide upon request by the U.S. Securities and Exchange Commission staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price.

Read SEC document
September 07, 2018 Filed Sep 10, 2018 20:13 UTC
Kauffman MichaelDirector · Chief Executive Officer
Exercise / conversionCommon Stock 12,500 $0.03 $412.50
Disclosure

SEC source: 0001209191-18-050236 · doc4.xml · nonDerivative · entry 1

Kauffman Michael · CIK 0001364719 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Indirect · By Spouse

Disclosed balance after: 726,010

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the spouse of the reporting person.

Read SEC document
September 07, 2018 Filed Sep 10, 2018 20:11 UTC
Shacham SharonPresident & CSO
Exercise / conversionStock Option (right to buy) · Derivative 12,500 $0.00 Strike: $0.03 $0.00
Disclosure

SEC source: 0001209191-18-050226 · doc4.xml · derivative · entry 6

Shacham Sharon · CIK 0001588438 · President & CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,764

Underlying: Common Stock · 12,500 shares

Expires 2020-10-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F5 · derivative.exercise_date: This option, representing a right to purchase a specified number of shares, vested as to 25% of the shares on October 22, 2011, and the remaining 75% vested in 36 equal monthly installments thereafter.

Read SEC document
September 07, 2018 Filed Sep 10, 2018 20:11 UTC
Shacham SharonPresident & CSO
SaleCommon Stock 12,500 $19.31 $241,383.75
Disclosure

SEC source: 0001209191-18-050226 · doc4.xml · nonDerivative · entry 2

Shacham Sharon · CIK 0001588438 · President & CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 713,510

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: Represents the weighted average sale price. These shares were sold in multiple transactions at prices ranging from $18.71 to $19.58, inclusive. The reporting person undertakes to provide upon request by the U.S. Securities and Exchange Commission staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price.

Read SEC document
September 07, 2018 Filed Sep 10, 2018 20:11 UTC
Shacham SharonPresident & CSO
Exercise / conversionCommon Stock 12,500 $0.03 $412.50
Disclosure

SEC source: 0001209191-18-050226 · doc4.xml · nonDerivative · entry 1

Shacham Sharon · CIK 0001588438 · President & CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 726,010

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

Read SEC document
September 06, 2018 Filed Sep 7, 2018 18:27 UTC
Chione Ltd10% owner
SaleCOMMON STOCK 4,800 $20.52 $98,473.92
Disclosure

SEC source: 0001213900-18-012296 · ownership.xml · nonDerivative · entry 2

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,631,267

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 09/05/2018 at prices ranging from $21.00 to $21.50, inclusive, and on 09/06/2018 at prices ranging from $20.50 to $20.605, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

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September 05, 2018 Filed Sep 7, 2018 18:27 UTC
Chione Ltd10% owner
SaleCOMMON STOCK 160,000 $21.06 $3,370,256.00
Disclosure

SEC source: 0001213900-18-012296 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,636,067

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 09/05/2018 at prices ranging from $21.00 to $21.50, inclusive, and on 09/06/2018 at prices ranging from $20.50 to $20.605, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

Read SEC document
September 04, 2018 Filed Sep 4, 2018 18:59 UTC
Chione Ltd10% owner
SaleCOMMON STOCK 40,000 $20.60 $824,072.00
Disclosure

SEC source: 0001213900-18-012091 · ownership.xml · nonDerivative · entry 3

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,796,067

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 08/30/2018 at prices ranging from $20.31 to $21.61, inclusive, on 08/31/2018 at prices ranging from $21.00 to $21.22, inclusive, and on 09/04/2018 at prices ranging from $20.50 to $20.82, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

Read SEC document
August 31, 2018 Filed Sep 4, 2018 18:59 UTC
Chione Ltd10% owner
SaleCOMMON STOCK 11,468 $21.05 $241,395.67
Disclosure

SEC source: 0001213900-18-012091 · ownership.xml · nonDerivative · entry 2

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,836,067

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 08/30/2018 at prices ranging from $20.31 to $21.61, inclusive, on 08/31/2018 at prices ranging from $21.00 to $21.22, inclusive, and on 09/04/2018 at prices ranging from $20.50 to $20.82, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

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August 31, 2018 Filed Sep 4, 2018 20:38 UTC GrantNonstatutory stock option (right to buy) · Derivative 34,000 $0.00 Strike: $21.05 $0.00
Disclosure

SEC source: 0001209191-18-049208 · doc4.xml · derivative · entry 1

Thiel Carsten · CIK 0001633582 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 34,000

Underlying: Common Stock · 34,000 shares

Expires 2028-08-30

F1 · derivative.exercise_date: This option was granted on August 31, 2018. The shares underlying this option vest as to one-third (1/3) of the shares on August 31, 2019 and as to the remaining two-thirds (2/3) of the shares in 24 equal monthly installments thereafter.

Read SEC document
August 30, 2018 Filed Sep 4, 2018 18:59 UTC
Chione Ltd10% owner
SaleCOMMON STOCK 200,000 $21.00 $4,199,900.00
Disclosure

SEC source: 0001213900-18-012091 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,847,535

F1 · price: The prices reported in Column 4 are weighted average prices. The shares were sold on 08/30/2018 at prices ranging from $20.31 to $21.61, inclusive, on 08/31/2018 at prices ranging from $21.00 to $21.22, inclusive, and on 09/04/2018 at prices ranging from $20.50 to $20.82, inclusive.

F2 · price: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

Read SEC document
August 30, 2018 Filed Sep 4, 2018 20:10 UTC Exercise / conversionStock Option (right to buy) · Derivative 264 $0.00 Strike: $5.64 $0.00
Disclosure

SEC source: 0001209191-18-049177 · doc4.xml · derivative · entry 5

Mirza Mansoor Raza · CIK 0001588389 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,342

Underlying: Common Stock · 264 shares

Expires 2023-09-30

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F3 · derivative.exercise_date: This option, representing a right to purchase a specified number of shares, vested as to 25% of the shares on October 1, 2014, and the remaining 75% vested in 36 equal monthly installments thereafter.

Read SEC document
August 30, 2018 Filed Sep 4, 2018 20:10 UTC Exercise / conversionStock Option (right to buy) · Derivative 2,236 $0.00 Strike: $1.49 $0.00
Disclosure

SEC source: 0001209191-18-049177 · doc4.xml · derivative · entry 4

Mirza Mansoor Raza · CIK 0001588389 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,236 shares

Expires 2022-12-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · derivative.exercise_date: This option, representing a right to purchase a specified number of shares, vested as to 25% of the shares on December 6, 2013, and the remaining 75% vested in 36 equal monthly installments thereafter.

Read SEC document
August 30, 2018 Filed Sep 4, 2018 20:10 UTC SaleCommon Stock 2,500 $21.00 $52,500.00
Disclosure

SEC source: 0001209191-18-049177 · doc4.xml · nonDerivative · entry 3

Mirza Mansoor Raza · CIK 0001588389 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

Read SEC document
August 30, 2018 Filed Sep 4, 2018 20:10 UTC Exercise / conversionCommon Stock 264 $5.64 $1,489.75
Disclosure

SEC source: 0001209191-18-049177 · doc4.xml · nonDerivative · entry 2

Mirza Mansoor Raza · CIK 0001588389 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 264

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

Read SEC document
August 30, 2018 Filed Sep 4, 2018 20:10 UTC Exercise / conversionCommon Stock 2,236 $1.49 $3,320.46
Disclosure

SEC source: 0001209191-18-049177 · doc4.xml · nonDerivative · entry 1

Mirza Mansoor Raza · CIK 0001588389 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,236

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

Read SEC document
August 29, 2018 Filed Aug 29, 2018 20:12 UTC
Chione Ltd10% owner
SaleCOMMON STOCK 200,000 $19.59 $3,918,280.00
Disclosure

SEC source: 0001213900-18-011892 · ownership.xml · nonDerivative · entry 2

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,047,535

F1 · shares: The prices reported in Column 4 are weighted average prices. The shares were sold on 08/27/2018 at prices ranging from $18.50 to $18.65, inclusive, and on 08/29/2018 at prices ranging from $19.00 to $20.01, inclusive.

F2 · shares: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

Read SEC document
August 29, 2018 Filed Aug 30, 2018 20:38 UTC Exercise / conversionStock Option (right to buy) · Derivative 2,500 $0.00 Strike: $1.49 $0.00
Disclosure

SEC source: 0001209191-18-048954 · doc4.xml · derivative · entry 3

Mirza Mansoor Raza · CIK 0001588389 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,236

Underlying: Common Stock · 2,500 shares

Expires 2022-12-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · derivative.exercise_date: This option, representing a right to purchase a specified number of shares, vested as to 25% of the shares on December 6, 2013, and the remaining 75% vested in 36 equal monthly installments thereafter.

Read SEC document
August 29, 2018 Filed Aug 30, 2018 20:38 UTC SaleCommon Stock 2,500 $20.00 $50,000.00
Disclosure

SEC source: 0001209191-18-048954 · doc4.xml · nonDerivative · entry 2

Mirza Mansoor Raza · CIK 0001588389 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

Read SEC document
August 29, 2018 Filed Aug 30, 2018 20:38 UTC Exercise / conversionCommon Stock 2,500 $1.49 $3,712.50
Disclosure

SEC source: 0001209191-18-048954 · doc4.xml · nonDerivative · entry 1

Mirza Mansoor Raza · CIK 0001588389 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,500

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

Read SEC document
August 27, 2018 Filed Aug 29, 2018 20:12 UTC
Chione Ltd10% owner
SaleCOMMON STOCK 14,026 $18.52 $259,775.55
Disclosure

SEC source: 0001213900-18-011892 · ownership.xml · nonDerivative · entry 1

Chione Ltd · CIK 0001590232 · 10% owner

Czernik Marcin · CIK 0001591275 · 10% owner

Hadjimichael Andreas · CIK 0001591256 · 10% owner

Hadjimichael George · CIK 0001674499 · 10% owner

Smolokowski Wiaczeslaw · CIK 0001591274 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,247,535

F1 · shares: The prices reported in Column 4 are weighted average prices. The shares were sold on 08/27/2018 at prices ranging from $18.50 to $18.65, inclusive, and on 08/29/2018 at prices ranging from $19.00 to $20.01, inclusive.

F2 · shares: The reporting persons undertake to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote 1 above.

F3 · balance_after: Shares of Common Stock are owned directly by Chione Limited ("Chione"). Chione's directors, Marcin Czernik, Andreas Hadjimichael and George Hadjimichael, may be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione. Wiaczeslaw Smolokowski, the sole shareholder of Chione, may also be deemed to share voting and investment power and beneficial ownership of the shares of Common Stock directly owned by Chione.

F4 · balance_after: Each reporting person states that neither the filing of this Form 4 nor anything herein shall be deemed an admission that such person or any other person is, for purposes of Section 16 of the Securities Exchange Act of 1934, as amended (the "Act"), or otherwise, the beneficial owner of any securities covered by this Form 4. Beneficial ownership of the securities covered by this statement is disclaimed.

F5 · balance_after: Each reporting person may be deemed to be a member of a group with respect to the issuer or securities of the issuer for purposes of Section 13(d) or 13(g) of the Act. Each reporting person declares that neither the filing of this Form 4 nor anything herein shall be construed as an admission that such person or any other person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, a member of a group with respect to the issuer or securities of the issuer.

Read SEC document
August 20, 2018 Filed Aug 21, 2018 20:11 UTC
Kauffman MichaelDirector · Chief Executive Officer
Exercise / conversionStock Option (right to buy) · Derivative 10,000 $0.00 Strike: $4.75 $0.00
Disclosure

SEC source: 0001209191-18-047739 · doc4.xml · derivative · entry 6

Kauffman Michael · CIK 0001364719 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 466,061

Underlying: Common Stock · 10,000 shares

Expires 2023-09-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F5 · derivative.exercise_date: This option, representing a right to purchase a specified number of shares, vested as to 25% of the shares on September 3, 2014, and the remaining 75% vested in 36 equal monthly installments thereafter.

Read SEC document
August 20, 2018 Filed Aug 21, 2018 20:11 UTC
Kauffman MichaelDirector · Chief Executive Officer
SaleCommon Stock 10,000 $17.46 $174,568.00
Disclosure

SEC source: 0001209191-18-047739 · doc4.xml · nonDerivative · entry 2

Kauffman Michael · CIK 0001364719 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 512,143

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

F2 · price: Represents the weighted average sale price. These shares were sold in multiple transactions at prices ranging from $17.20 to $17.83, inclusive. The reporting person undertakes to provide upon request by the U.S. Securities and Exchange Commission staff, the issuer or a security holder of the issuer, full information regarding the number of shares sold at each separate price.

Read SEC document
August 20, 2018 Filed Aug 21, 2018 20:11 UTC
Kauffman MichaelDirector · Chief Executive Officer
Exercise / conversionCommon Stock 10,000 $4.75 $47,520.00
Disclosure

SEC source: 0001209191-18-047739 · doc4.xml · nonDerivative · entry 1

Kauffman Michael · CIK 0001364719 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 522,143

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: These transactions were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person.

Read SEC document

Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.