JAZZ

SEC source: 0001751804-26-000002 · edgardoc.xml · nonDerivative · entry 1

Hamill Laura · CIK 0001751804 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,538

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 23, 2027.

SEC source: 0001756253-26-000006 · edgardoc.xml · nonDerivative · entry 1

Smith Mark Douglas · CIK 0001756253 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 11,285

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 23, 2027.

SEC source: 0001754371-26-000004 · edgardoc.xml · nonDerivative · entry 1

Cook Jennifer E. · CIK 0001754371 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,442

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 23, 2027.

SEC source: 0001536639-26-000004 · edgardoc.xml · nonDerivative · entry 1

Mulligan Seamus · CIK 0001536639 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,184,633

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 23, 2027.

SEC source: 0001253886-26-000008 · edgardoc.xml · nonDerivative · entry 1

ENRIGHT PATRICK G · CIK 0001253886 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 22,984

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 23, 2027.

SEC source: 0001193210-26-000020 · edgardoc.xml · nonDerivative · entry 1

COZADD BRUCE C · CIK 0001193210 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 362,287

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2007 Amended and Restated Non-Employee Directors Stock Award Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. Subject to the Reporting Person's continuous service and certain additional conditions, these units will vest in full on July 23, 2027.

SEC source: 0001193210-26-000018 · edgardoc.xml · nonDerivative · entry 1

COZADD BRUCE C · CIK 0001193210 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 360,682

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on November 26, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

SEC source: 0001193210-26-000016 · edgardoc.xml · nonDerivative · entry 1

COZADD BRUCE C · CIK 0001193210 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 366,682

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on November 26, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

SEC source: 0001805688-26-000012 · edgardoc.xml · nonDerivative · entry 1

Pearce Samantha · CIK 0001805688 · EVP, Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 47,911

F1 · kind: Shares withheld to satisfy tax obligations arising out of vesting of a portion of previously granted restricted stock units.

F2 · balance_after: The Reporting Person acquired 166 ordinary shares under a Section 423 Employee Stock Purchase Plan on May 29, 2026.

SEC source: 0002013156-26-000007 · edgardoc.xml · nonDerivative · entry 1

Johnson Philip L · CIK 0002013156 · EVP & Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 56,431

F1 · kind: Shares withheld to satisfy tax obligations arising out of vesting of a portion of previously granted restricted stock units.

F2 · balance_after: The Reporting Person acquired 166 ordinary shares under a Section 423 Employee Stock Purchase Plan on May 29, 2026.

SEC source: 0001737329-26-000010 · edgardoc.xml · nonDerivative · entry 1

Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 85,107

F1 · kind: Shares withheld to satisfy tax obligations arising out of vesting of a portion of previously granted restricted stock units.

SEC source: 0001607737-26-000011 · edgardoc.xml · nonDerivative · entry 1

GALA RENEE D · CIK 0001607737 · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 147,361

F1 · kind: Shares withheld to satisfy tax obligations arising out of vesting of a portion of previously granted restricted stock units.

SEC source: 0001783908-26-000019 · edgardoc.xml · nonDerivative · entry 1

Patil Neena M · CIK 0001783908 · EVP & Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 48,871

F1 · kind: Shares withheld to satisfy tax obligations arising out of vesting of a portion of previously granted restricted stock units.

SEC source: 0001756253-26-000004 · edgardoc.xml · nonDerivative · entry 1

Smith Mark Douglas · CIK 0001756253 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 9,680

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on March 9, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

SEC source: 0001783908-26-000017 · edgardoc.xml · nonDerivative · entry 1

Patil Neena M · CIK 0001783908 · EVP & Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 51,549

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on February 26, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

F2 · balance_after: The Reporting Person acquired 123 ordinary shares under a Section 423 Employee Stock Purchase Plan on May 29, 2026.

SEC source: 0001607737-26-000008 · edgardoc.xml · nonDerivative · entry 1

GALA RENEE D · CIK 0001607737 · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 152,196

F1 · kind: Shares were donated to The Gala Family Fund, a donor-advised fund.

F2 · balance_after: The Reporting Person acquired 166 ordinary shares under a Section 423 Employee Stock Purchase Plan on May 29, 2026.

SEC source: 0001193210-26-000013 · edgardoc.xml · nonDerivative · entry 1

COZADD BRUCE C · CIK 0001193210 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 372,682

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on November 26, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

SEC source: 0001805688-26-000008 · edgardoc.xml · derivative · entry 3

Pearce Samantha · CIK 0001805688 · EVP, Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 6,907 shares

Expires 2030-05-06

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: These options were granted pursuant to the Issuer's 2011 Equity Incentive Plan. The ordinary shares subject to these options vest over four years measured from the vesting commencement date of March 2, 2020, 1/4th vested on the first anniversary of the vesting commencement date and the remainder vested in 36 equal monthly installments thereafter. The option was fully vested as of March 2, 2024.

SEC source: 0001805688-26-000008 · edgardoc.xml · nonDerivative · entry 2

Pearce Samantha · CIK 0001805688 · EVP, Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,272

SEC source: 0001805688-26-000008 · edgardoc.xml · nonDerivative · entry 1

Pearce Samantha · CIK 0001805688 · EVP, Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 57,179

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001783908-26-000014 · edgardoc.xml · nonDerivative · entry 1

Patil Neena M · CIK 0001783908 · EVP & Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 52,626

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on February 26, 2026 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

SEC source: 0001536639-26-000002 · edgardoc.xml · derivative · entry 3

Mulligan Seamus · CIK 0001536639 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 3,415 shares

Expires 2026-08-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: This non-qualified stock option was granted on August 11, 2016 and vested over the period from September 1, 2016 through August 1, 2017. The options were fully vested as of August 1, 2017.

SEC source: 0001536639-26-000002 · edgardoc.xml · nonDerivative · entry 1

Mulligan Seamus · CIK 0001536639 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,183,028

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001576068-26-000002 · edgardoc.xml · nonDerivative · entry 1

McSharry Heather Ann · CIK 0001576068 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 18,449

SEC source: 0001302443-26-000008 · edgardoc.xml · derivative · entry 3

Winningham Rick E · CIK 0001302443 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 3,415 shares

Expires 2026-08-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: This non-qualified stock option was granted on August 11, 2016 and vested over a period of one year from September 1, 2016. The options were fully vested as of August 1, 2017.

SEC source: 0001302443-26-000008 · edgardoc.xml · nonDerivative · entry 2

Winningham Rick E · CIK 0001302443 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,567

SEC source: 0001302443-26-000008 · edgardoc.xml · nonDerivative · entry 1

Winningham Rick E · CIK 0001302443 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,308

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001193210-26-000011 · edgardoc.xml · nonDerivative · entry 1

COZADD BRUCE C · CIK 0001193210 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 378,682

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on November 26, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

SEC source: 0001193210-26-000009 · edgardoc.xml · nonDerivative · entry 3

COZADD BRUCE C · CIK 0001193210 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 384,682

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on November 26, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

SEC source: 0001193210-26-000009 · edgardoc.xml · nonDerivative · entry 2

COZADD BRUCE C · CIK 0001193210 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 384,706

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on November 26, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

F3 · price: Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $190.6051 to $190.5982. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

SEC source: 0001193210-26-000009 · edgardoc.xml · nonDerivative · entry 1

COZADD BRUCE C · CIK 0001193210 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 386,998

F1 · kind: This transaction was made pursuant to a plan adopted by the reporting person on November 26, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended. The transaction occurred automatically and does not represent a discretionary transaction by the reporting person.

F2 · price: Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $189.60 to $190.5603. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

SEC source: 0001784606-26-000012 · edgardoc.xml · nonDerivative · entry 2

Carr Patricia · CIK 0001784606 · SVP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 6,512

SEC source: 0001805688-26-000006 · edgardoc.xml · nonDerivative · entry 1

Pearce Samantha · CIK 0001805688 · EVP, Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,272

F1 · kind: Shares withheld to satisfy tax obligations arising out of vesting of a portion of previously granted restricted stock units.

SEC source: 0002013156-26-000004 · edgardoc.xml · nonDerivative · entry 1

Johnson Philip L · CIK 0002013156 · EVP & Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 59,608

F1 · kind: Shares withheld to satisfy tax obligations arising out of vesting of a portion of previously granted restricted stock units.

SEC source: 0001737329-26-000006 · edgardoc.xml · nonDerivative · entry 1

Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 88,871

F1 · kind: Shares withheld to satisfy tax obligations arising out of vesting of a portion of previously granted restricted stock units.

SEC source: 0001193210-26-000007 · edgardoc.xml · nonDerivative · entry 1

COZADD BRUCE C · CIK 0001193210 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 390,682

F1 · kind: Shares withheld to satisfy tax obligations arising out of vesting of a portion of previously granted restricted stock units.

SEC source: 0001989533-26-000011 · edgardoc.xml · nonDerivative · entry 1

Henderson Mary Elizabeth · CIK 0001989533 · SVP, Technical Operations

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 27,334

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

F2 · price: Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $186.1633 to $186.7558. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

SEC source: 0001784606-26-000012 · edgardoc.xml · nonDerivative · entry 1

Carr Patricia · CIK 0001784606 · SVP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,799

F1 · kind: Shares sold to satisfy tax obligations arising out of the vesting of previously granted restricted stock units.

F2 · price: Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $186.06 to $186.9115. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

SEC source: 0001607737-26-000006 · edgardoc.xml · nonDerivative · entry 1

GALA RENEE D · CIK 0001607737 · President & CEO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 152,630

F1 · kind: Shares withheld to satisfy tax obligations arising out of vesting of a portion of previously granted restricted stock units.

SEC source: 0001783908-26-000010 · edgardoc.xml · nonDerivative · entry 1

Patil Neena M · CIK 0001783908 · EVP & Chief Legal Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 53,818

F1 · kind: Shares withheld to satisfy tax obligations arising out of vesting of a portion of previously granted restricted stock units.

SEC source: 0001193210-26-000005 · edgardoc.xml · nonDerivative · entry 3

COZADD BRUCE C · CIK 0001193210 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 405,796

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F4 · price: Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $187.7783 to $188.1678 The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

SEC source: 0001193210-26-000005 · edgardoc.xml · nonDerivative · entry 2

COZADD BRUCE C · CIK 0001193210 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 406,029

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F3 · price: Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $186.500 to $187.4693. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

SEC source: 0001193210-26-000005 · edgardoc.xml · nonDerivative · entry 1

COZADD BRUCE C · CIK 0001193210 · Director

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 408,637

F1 · kind: This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person.

F2 · price: Reflects sales of ordinary shares executed in multiple transactions at prices ranging from $185.500 to $186.4207. The price reported reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the Securities and Exchange Commission staff, the Issuer or a security holder of the Issuer full information regarding the number of shares and prices at which the sales were effected.

SEC source: 0001161662-26-000002 · edgardoc.xml · derivative · entry 4

RIEDEL NORBERT G · CIK 0001161662 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Ordinary Shares · 3,415 shares

Expires 2026-08-10

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: This non-qualified stock option was granted on August 11, 2016 and vested over a period of one year from September 1, 2016. The options were fully vested as of August 1, 2017.

SEC source: 0001161662-26-000002 · edgardoc.xml · nonDerivative · entry 2

RIEDEL NORBERT G · CIK 0001161662 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,024

SEC source: 0001161662-26-000002 · edgardoc.xml · nonDerivative · entry 1

RIEDEL NORBERT G · CIK 0001161662 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 10,439

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001784606-26-000007 · edgardoc.xml · nonDerivative · entry 3

Carr Patricia · CIK 0001784606 · SVP, Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 9,235

SEC source: 0001805688-26-000004 · edgardoc.xml · nonDerivative · entry 1

Pearce Samantha · CIK 0001805688 · EVP, Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 52,775

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2011 Equity Incentive Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. These units vest in equal annual installments over four years measured from the vesting commencement date of March 5, 2026, with 1/4th vesting on the first anniversary of the vesting commencement date and the remainder vesting in equal annual installments over the subsequent three years.

SEC source: 0002013156-26-000002 · edgardoc.xml · nonDerivative · entry 1

Johnson Philip L · CIK 0002013156 · EVP & Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 62,223

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2011 Equity Incentive Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. These units vest in equal annual installments over four years measured from the vesting commencement date of March 5, 2026, with 1/4th vesting on the first anniversary of the vesting commencement date and the remainder vesting in equal annual installments over the subsequent three years.

F2 · balance_after: The Reporting Person acquired 166 ordinary shares on May 30, 2025 and 140 shares on November 28, 2025 under a Section 423 Employee Stock Purchase Plan.

SEC source: 0001737329-26-000004 · edgardoc.xml · nonDerivative · entry 1

Iannone Robert · CIK 0001737329 · EVP, Global Head of R&D & CMO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 95,080

F1 · kind: These restricted stock units are granted pursuant to the Issuer's 2011 Equity Incentive Plan. Each restricted stock unit represents a contingent right to receive one ordinary share upon the vesting of the unit. These units vest in equal annual installments over four years measured from the vesting commencement date of March 5, 2026, with 1/4th vesting on the first anniversary of the vesting commencement date and the remainder vesting in equal annual installments over the subsequent three years.