IVVD

SEC source: 0000950170-24-138597 · ownership.xml · nonDerivative · entry 3

MCGUIRE TERRANCE · CIK 0001117003 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 3,688,079

F4 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $0.4281 to $0.4500, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (4) to this Form 4.

F2 · ownership.nature: These shares are held of record by Polaris Partners IX, L.P. ("PP IX"). The general partner of PP IX is Polaris Partners GP IX, L.L.C. ("PP GP IX") and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PP IX. The Reporting Person, a member of the Issuer's board of directors, holds an interest in PP GP IX and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PP IX. Each of PP GP IX and the Reporting Person disclaims beneficial ownership of the shares reported herein, except to the extent of their respective pecuniary interests therein. The filing of this statement shall not be deemed to be an admission that, for purposes of Section 16 of the Securities Exchange Act of 1934 or otherwise, neither PP GP IX nor the Reporting Person is the beneficial owner of any shares reported herein.

SEC source: 0000950170-24-138597 · ownership.xml · nonDerivative · entry 2

MCGUIRE TERRANCE · CIK 0001117003 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 3,840,146

F3 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $0.4500 to $0.5024, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (3) to this Form 4.

F2 · ownership.nature: These shares are held of record by Polaris Partners IX, L.P. ("PP IX"). The general partner of PP IX is Polaris Partners GP IX, L.L.C. ("PP GP IX") and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PP IX. The Reporting Person, a member of the Issuer's board of directors, holds an interest in PP GP IX and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PP IX. Each of PP GP IX and the Reporting Person disclaims beneficial ownership of the shares reported herein, except to the extent of their respective pecuniary interests therein. The filing of this statement shall not be deemed to be an admission that, for purposes of Section 16 of the Securities Exchange Act of 1934 or otherwise, neither PP GP IX nor the Reporting Person is the beneficial owner of any shares reported herein.

SEC source: 0000950170-24-138597 · ownership.xml · nonDerivative · entry 1

MCGUIRE TERRANCE · CIK 0001117003 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 3,914,910

F1 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $0.4500 to $0.5055, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (1) to this Form 4.

F2 · ownership.nature: These shares are held of record by Polaris Partners IX, L.P. ("PP IX"). The general partner of PP IX is Polaris Partners GP IX, L.L.C. ("PP GP IX") and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PP IX. The Reporting Person, a member of the Issuer's board of directors, holds an interest in PP GP IX and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PP IX. Each of PP GP IX and the Reporting Person disclaims beneficial ownership of the shares reported herein, except to the extent of their respective pecuniary interests therein. The filing of this statement shall not be deemed to be an admission that, for purposes of Section 16 of the Securities Exchange Act of 1934 or otherwise, neither PP GP IX nor the Reporting Person is the beneficial owner of any shares reported herein.

SEC source: 0000950170-24-136858 · ownership.xml · nonDerivative · entry 2

MCGUIRE TERRANCE · CIK 0001117003 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 4,012,320

F3 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $0.4501 to $0.4959, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (3) to this Form 4.

F2 · ownership.nature: These shares are held of record by Polaris Partners IX, L.P. ("PP IX"). The general partner of PP IX is Polaris Partners GP IX, L.L.C. ("PP GP IX") and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PP IX. The Reporting Person, a member of the Issuer's board of directors, holds an interest in PP GP IX and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PP IX. Each of PP GP IX and the Reporting Person disclaims beneficial ownership of the shares reported herein, except to the extent of their respective pecuniary interests therein. The filing of this statement shall not be deemed to be an admission that, for purposes of Section 16 of the Securities Exchange Act of 1934 or otherwise, neither PP GP IX nor the Reporting Person is the beneficial owner of any shares reported herein.

SEC source: 0000950170-24-136858 · ownership.xml · nonDerivative · entry 1

MCGUIRE TERRANCE · CIK 0001117003 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 4,077,679

F1 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $0.5800 to $0.5978, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (1) to this Form 4.

F2 · ownership.nature: These shares are held of record by Polaris Partners IX, L.P. ("PP IX"). The general partner of PP IX is Polaris Partners GP IX, L.L.C. ("PP GP IX") and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PP IX. The Reporting Person, a member of the Issuer's board of directors, holds an interest in PP GP IX and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PP IX. Each of PP GP IX and the Reporting Person disclaims beneficial ownership of the shares reported herein, except to the extent of their respective pecuniary interests therein. The filing of this statement shall not be deemed to be an admission that, for purposes of Section 16 of the Securities Exchange Act of 1934 or otherwise, neither PP GP IX nor the Reporting Person is the beneficial owner of any shares reported herein.

SEC source: 0000950170-24-135509 · ownership.xml · nonDerivative · entry 3

MCGUIRE TERRANCE · CIK 0001117003 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 4,202,679

F4 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $0.5800 to $0.6200, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (4) to this Form 4.

F2 · ownership.nature: These shares are held of record by Polaris Partners IX, L.P. ("PP IX"). The general partner of PP IX is Polaris Partners GP IX, L.L.C. ("PP GP IX") and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PP IX. The Reporting Person, a member of the Issuer's board of directors, holds an interest in PP GP IX and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PP IX. Each of PP GP IX and the Reporting Person disclaims beneficial ownership of the shares reported herein, except to the extent of their respective pecuniary interests therein. The filing of this statement shall not be deemed to be an admission that, for purposes of Section 16 of the Securities Exchange Act of 1934 or otherwise, neither PP GP IX nor the Reporting Person is the beneficial owner of any shares reported herein.

SEC source: 0000950170-24-135509 · ownership.xml · nonDerivative · entry 2

MCGUIRE TERRANCE · CIK 0001117003 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 4,363,079

F3 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $0.5800 to $0.6018, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (3) to this Form 4.

F2 · ownership.nature: These shares are held of record by Polaris Partners IX, L.P. ("PP IX"). The general partner of PP IX is Polaris Partners GP IX, L.L.C. ("PP GP IX") and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PP IX. The Reporting Person, a member of the Issuer's board of directors, holds an interest in PP GP IX and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PP IX. Each of PP GP IX and the Reporting Person disclaims beneficial ownership of the shares reported herein, except to the extent of their respective pecuniary interests therein. The filing of this statement shall not be deemed to be an admission that, for purposes of Section 16 of the Securities Exchange Act of 1934 or otherwise, neither PP GP IX nor the Reporting Person is the beneficial owner of any shares reported herein.

SEC source: 0000950170-24-135509 · ownership.xml · nonDerivative · entry 1

MCGUIRE TERRANCE · CIK 0001117003 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 4,538,079

F1 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $0.6000 to $0.6540, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (1) to this Form 4.

F2 · ownership.nature: These shares are held of record by Polaris Partners IX, L.P. ("PP IX"). The general partner of PP IX is Polaris Partners GP IX, L.L.C. ("PP GP IX") and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PP IX. The Reporting Person, a member of the Issuer's board of directors, holds an interest in PP GP IX and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PP IX. Each of PP GP IX and the Reporting Person disclaims beneficial ownership of the shares reported herein, except to the extent of their respective pecuniary interests therein. The filing of this statement shall not be deemed to be an admission that, for purposes of Section 16 of the Securities Exchange Act of 1934 or otherwise, neither PP GP IX nor the Reporting Person is the beneficial owner of any shares reported herein.

SEC source: 0000950170-24-069965 · ownership.xml · derivative · entry 1

Lee Timothy Edward · CIK 0002025331 · Chief Commercial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 600,000

Underlying: Common Stock · 600,000 shares

Expires 2034-06-04

F1 · derivative.exercise_date: This option vests over a four-year period, with 25% of the shares subject to the option vesting on the first anniversary of the grant date of June 5, 2024 and the remaining 75% of the shares subject to the option vesting over the subsequent three-year period in substantially equal monthly installments at a rate of 1/48th of the total shares subject to the option each month, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0000950170-24-067438 · ownership.xml · nonDerivative · entry 1

MCGUIRE TERRANCE · CIK 0001117003 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · See Footnote

Disclosed balance after: 4,688,079

F1 · price: The price reported in Column 4 is a weighted average price. These securities were sold in multiple transactions at prices ranging from $1.6500 to $1.7200, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of securities sold at each separate price within the ranges set forth in this footnote (1) to this Form 4.

F2 · ownership.nature: These shares are held of record by Polaris Partners IX, L.P. ("PP IX"). The general partner of PP IX is Polaris Partners GP IX, L.L.C. ("PP GP IX") and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PP IX. The Reporting Person holds an interest in PP GP IX and may be deemed to have shared voting, investment and dispositive power with respect to the shares held by PP IX. Each of PP GP IX and the Reporting Person disclaims beneficial ownership of the shares reported herein, except to the extent of their respective pecuniary interests therein. The filing of this statement shall not be deemed to be an admission that, for purposes of Section 16 of the Securities Exchange Act of 1934 or otherwise, neither PP GP IX nor the Reporting Person is the beneficial owner of any shares reported herein.

SEC source: 0000950170-24-064126 · ownership.xml · derivative · entry 1

Berry Tamsin · CIK 0001924202 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2034-05-20

F1 · derivative.exercise_date: This option was granted on May 21, 2024 and vests in full upon the earlier of (i) May 21, 2025 or (ii) the date of the Issuer's 2025 Annual Meeting of Stockholders, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0000950170-24-064152 · ownership.xml · derivative · entry 1

MCGUIRE TERRANCE · CIK 0001117003 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2034-05-20

F1 · derivative.exercise_date: This option was granted on May 21, 2024 and vests in full upon the earlier of (i) May 21, 2025 or (ii) the date of the Issuer's 2025 Annual Meeting of Stockholders, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0000950170-24-064007 · ownership.xml · derivative · entry 1

Gupta Srishti · CIK 0002024011 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2034-05-20

F1 · derivative.exercise_date: This option was granted on May 21, 2024 and vests over a three-year period, with one-third of the shares subject to the grant vesting on the first anniversary of the grant date and 1/36th of the total shares subject to the grant vesting in substantially equal monthly installments thereafter, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0000950170-24-064113 · ownership.xml · derivative · entry 1

Elia Marc · CIK 0001830496 · Director · See Remarks

M28 Capital Management LP · CIK 0001807489 · See Remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2034-05-20

F1 · derivative.exercise_date: This option was granted on May 21, 2024 and vests in full upon the earlier of (i) May 21, 2025 or (ii) the date of the Issuer's 2025 Annual Meeting of Stockholders, subject to the Reporting Person's continuous service through such vesting date. The grant was awarded to Marc Elia ("Mr. Elia"). Mr. Elia is deemed to hold the grant for the benefit of M28 Capital Management LP ("M28 Capital Management") and the funds managed by M28 Capital Management.

SEC source: 0000950170-24-064138 · ownership.xml · derivative · entry 1

MCLAUGHLIN KEVIN F · CIK 0001214938 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2034-05-20

F1 · derivative.exercise_date: This option was granted on May 21, 2024 and vests over a three-year period, with one-third of the shares subject to the grant vesting on the first anniversary of the grant date and 1/36th of the total shares subject to the grant vesting in substantially equal monthly installments thereafter, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0000950170-24-064146 · ownership.xml · derivative · entry 1

Cotter Sara · CIK 0001969809 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 41,369

Underlying: Common Stock · 41,369 shares

Expires 2034-05-20

F1 · derivative.exercise_date: This option was granted on May 21, 2024 and vests in full upon the earlier of (i) May 21, 2025 or (ii) the date of the Issuer's 2025 Annual Meeting of Stockholders, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0000950170-24-064071 · ownership.xml · derivative · entry 1

Lindenboom Christine · CIK 0001950692 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2034-05-20

F1 · derivative.exercise_date: This option was granted on May 21, 2024 and vests in full upon the earlier of (i) May 21, 2025 or (ii) the date of the Issuer's 2025 Annual Meeting of Stockholders, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0000950170-24-007981 · ownership.xml · derivative · entry 1

Green Julie · CIK 0002008797 · Chief Human Resources Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 240,000

Underlying: Common Stock · 240,000 shares

Expires 2034-01-23

F1 · derivative.exercise_date: This option vests over a three-year period, with 1/36th of the shares subject to the option vesting in substantially equal monthly installments measured from one month following the grant date of January 24, 2024, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0000950170-24-006070 · ownership.xml · nonDerivative · entry 1

Adimab, LLC · CIK 0001545672 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 21,687,906

SEC source: 0000950170-23-071919 · ownership.xml · derivative · entry 1

Gowler Jeremy · CIK 0001957345 · COO & CCO

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 400,000

Underlying: Common Stock · 400,000 shares

Expires 2033-12-17

F1 · derivative.exercise_date: This option vests over a three-year period, with 1/36th of the shares subject to the option vesting in substantially equal monthly installments measured from one month following the grant date of December 18, 2023, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0000950170-23-071918 · ownership.xml · derivative · entry 1

Hering David · CIK 0001875613 · Director · Chief Executive Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 950,000

Underlying: Common Stock · 950,000 shares

Expires 2033-12-17

F1 · derivative.exercise_date: This option vests over a three-year period, with 1/36th of the shares subject to the option vesting in substantially equal monthly installments measured from one month following the grant date of December 18, 2023, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0000950170-23-071907 · ownership.xml · derivative · entry 1

Duke William E. · CIK 0001636135 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 200,000

Underlying: Common Stock · 200,000 shares

Expires 2033-12-17

F1 · derivative.exercise_date: This option vests over a three-year period, with 1/36th of the shares subject to the option vesting in substantially equal monthly installments measured from one month following the grant date of December 18, 2023, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0000950170-23-071915 · ownership.xml · derivative · entry 1

Schmidt Peter · CIK 0001956777 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 400,000

Underlying: Common Stock · 400,000 shares

Expires 2033-12-17

F1 · derivative.exercise_date: This option vests over a three-year period, with 1/36th of the shares subject to the option vesting in substantially equal monthly installments measured from one month following the grant date of December 18, 2023, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0000950170-23-071914 · ownership.xml · derivative · entry 1

Price Stacy · CIK 0001969943 · Chief Tech. and Manuf. Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 400,000

Underlying: Common Stock · 400,000 shares

Expires 2033-12-17

F1 · derivative.exercise_date: This option vests over a three-year period, with 1/36th of the shares subject to the option vesting in substantially equal monthly installments measured from one month following the grant date of December 18, 2023, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0000950170-23-071905 · ownership.xml · derivative · entry 1

Allen Robert D. III · CIK 0001972424 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 400,000

Underlying: Common Stock · 400,000 shares

Expires 2033-12-17

F1 · derivative.exercise_date: This option vests over a three-year period, with 1/36th of the shares subject to the option vesting in substantially equal monthly installments measured from one month following the grant date of December 18, 2023, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0000950170-23-071909 · ownership.xml · derivative · entry 1

Andersen Jill · CIK 0001891047 · Chief Legal Officer, Secretary

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 400,000

Underlying: Common Stock · 400,000 shares

Expires 2033-12-17

F1 · derivative.exercise_date: This option vests over a three-year period, with 1/36th of the shares subject to the option vesting in substantially equal monthly installments measured from one month following the grant date of December 18, 2023, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0000950170-23-065108 · ownership.xml · derivative · entry 1

Andersen Jill · CIK 0001891047 · Chief Legal Officer, Secretary

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 325,000

Underlying: Common Stock · 325,000 shares

Expires 2033-11-16

F1 · derivative.exercise_date: This option vests over a four-year period, with 25% of the shares subject to the option vesting on the first anniversary of the grant date of November 17, 2023 and the remaining 75% of the shares subject to the option vesting over the subsequent three-year period in substantially equal monthly installments at a rate of 1/48th of the total shares subject to the option each month, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0000950170-23-046430 · ownership.xml · derivative · entry 1

Duke William E. · CIK 0001636135 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 750,000

Underlying: Common Stock · 750,000 shares

Expires 2033-08-31

F1 · derivative.exercise_date: This option vests over a four-year period, with 25% of the shares subject to the option vesting on the first anniversary of the grant date of September 1, 2023 and the remaining 75% of the shares subject to the option vesting over the subsequent three-year period in substantially equal monthly installments at a rate of 1/48th of the total shares subject to the option each month, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0000950170-23-035191 · ownership.xml · derivative · entry 1

Cotter Sara · CIK 0001969809 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2033-07-24

F1 · derivative.exercise_date: This option was granted on July 25, 2023 and vests over a three-year period, with one-third of the shares subject to the grant vesting on the first anniversary of the grant date and 1/36th of the total shares subject to the grant vesting in substantially equal monthly installments thereafter, subject to the Reporting Person's continuous service through each vesting date.

SEC source: 0000899243-23-013913 · doc4.xml · derivative · entry 1

Berry Tamsin · CIK 0001924202 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2033-05-22

F1 · derivative.exercise_date: This option was granted on May 23, 2023 and vests in full upon the earlier of (i) May 23, 2024 or (ii) the date of the Issuer's 2024 Annual Meeting of Stockholders, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0000899243-23-013935 · doc4.xml · derivative · entry 1

MCGUIRE TERRANCE · CIK 0001117003 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2033-05-22

F1 · derivative.exercise_date: This option was granted on May 23, 2023 and vests in full upon the earlier of (i) May 23, 2024 or (ii) the date of the Issuer's 2024 Annual Meeting of Stockholders, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0000899243-23-013912 · doc4.xml · derivative · entry 1

Elia Marc · CIK 0001830496 · Director · See Remarks

M28 Capital Management LP · CIK 0001807489 · See Remarks

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2033-05-22

F1 · derivative.exercise_date: This option was granted on May 23, 2023 and vests in full upon the earlier of (i) May 23, 2024 or (ii) the date of the Issuer's 2024 Annual Meeting of Stockholders, subject to the Reporting Person's continuous service through such vesting date. The grant was awarded to Marc Elia ("Mr. Elia"). Mr. Elia is deemed to hold the grant for the benefit of M28 Capital Management LP ("M28 Capital Management") and the funds managed by M28 Capital Management.

SEC source: 0000899243-23-013916 · doc4.xml · derivative · entry 1

MEANWELL CLIVE · CIK 0001204787 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2033-05-22

F1 · derivative.exercise_date: This option was granted on May 23, 2023 and vests in full upon the earlier of (i) May 23, 2024 or (ii) the date of the Issuer's 2024 Annual Meeting of Stockholders, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0000899243-23-013918 · doc4.xml · derivative · entry 1

WYZGA MICHAEL S · CIK 0001201256 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2033-05-22

F1 · derivative.exercise_date: This option was granted on May 23, 2023 and vests in full upon the earlier of (i) May 23, 2024 or (ii) the date of the Issuer's 2024 Annual Meeting of Stockholders, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0000899243-23-013920 · doc4.xml · derivative · entry 1

Heyman Tomas J. · CIK 0001814673 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 50,000

Underlying: Common Stock · 50,000 shares

Expires 2033-05-22

F1 · derivative.exercise_date: This option was granted on May 23, 2023 and vests in full upon the earlier of (i) May 23, 2024 or (ii) the date of the Issuer's 2024 Annual Meeting of Stockholders, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0000899243-23-013917 · doc4.xml · derivative · entry 1

Lindenboom Christine · CIK 0001950692 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 29,589

Underlying: Common Stock · 29,589 shares

Expires 2033-05-22

F1 · derivative.exercise_date: This option was granted on May 23, 2023 and vests in full upon the earlier of (i) May 23, 2024 or (ii) the date of the Issuer's 2024 Annual Meeting of Stockholders, subject to the Reporting Person's continuous service through such vesting date.

SEC source: 0000899243-23-011197 · doc4.xml · derivative · entry 1

Allen Robert D. III · CIK 0001972424 · Chief Scientific Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 600,000

Underlying: Common Stock · 600,000 shares

Expires 2033-04-10

F1 · derivative.exercise_date: This option vests over a four-year period, with 25% of the shares subject to the option vesting on the first anniversary of the grant date of April 11, 2023 and the remaining 75% of the shares subject to the option vesting over the subsequent three-year period in substantially equal monthly installments at a rate of 1/48th of the total shares subject to the option each month, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0000899243-23-009798 · doc4.xml · derivative · entry 1

Price Stacy · CIK 0001969943 · Chief Tech. and Manuf. Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 475,000

Underlying: Common Stock · 475,000 shares

Expires 2033-03-26

F1 · derivative.exercise_date: This option vests over a four-year period, with 25% of the shares subject to the option vesting on the first anniversary of the grant date of March 27, 2023 and the remaining 75% of the shares subject to the option vesting over the subsequent three-year period in substantially equal monthly installments at a rate of 1/48th of the total shares subject to the option each month, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0000899243-22-038845 · doc4.xml · derivative · entry 1

Gowler Jeremy · CIK 0001957345 · COO & CCO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 625,000

Underlying: Common Stock · 625,000 shares

Expires 2032-12-15

F1 · derivative.exercise_date: This option vests over a four-year period, with 25% of the shares subject to the option vesting on the first anniversary of the grant date of December 16, 2022 and the remaining 75% of the shares subject to the option vesting over the subsequent three-year period in substantially equal monthly installments at a rate of 1/48th of the total shares subject to the option each month, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0000899243-22-038843 · doc4.xml · derivative · entry 2

Hering David · CIK 0001875613 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 900,000

Underlying: Common Stock · 900,000 shares

Expires 2032-12-13

F3 · derivative.exercise_date: This option vests over a three-year period, with 1/36th of the shares subject to the option vesting in substantially equal monthly installments measured from one month following the grant date of December 14, 2022, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0000899243-22-038843 · doc4.xml · derivative · entry 1

Hering David · CIK 0001875613 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 700,000

Underlying: Common Stock · 700,000 shares

Expires 2032-12-13

F1 · security: This option grant is made pursuant to the Reporting Person's achievement of certain performance goals as contemplated by Section 2(g) of that certain Employment Agreement, dated July 5, 2022, between the Reporting Person and the Issuer, as previously disclosed in a Current Report on Form 8-K filed by the Issuer on July 5, 2022.

F2 · derivative.exercise_date: This option vests over a four-year period, with 1/48th of the shares subject to the option vesting in substantially equal monthly installments measured from one month following the grant date of December 14, 2022, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0000899243-22-038853 · doc4.xml · derivative · entry 1

Dabora Rebecca · CIK 0001875611 · Chief Tech and Manuf Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2032-12-13

F1 · derivative.exercise_date: This option vests over a three-year period, with 1/36th of the shares subject to the option vesting in substantially equal monthly installments measured from one month following the grant date of December 14, 2022, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0000899243-22-038851 · doc4.xml · derivative · entry 1

Andersen Jill · CIK 0001891047 · Chief Legal Officer, Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 300,000

Underlying: Common Stock · 300,000 shares

Expires 2032-12-13

F1 · derivative.exercise_date: This option vests over a three-year period, with 1/36th of the shares subject to the option vesting in substantially equal monthly installments measured from one month following the grant date of December 14, 2022, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0000899243-22-038849 · doc4.xml · derivative · entry 1

Schmidt Peter · CIK 0001956777 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 200,000

Underlying: Common Stock · 200,000 shares

Expires 2032-12-13

F1 · derivative.exercise_date: This option vests over a three-year period, with 1/36th of the shares subject to the option vesting in substantially equal monthly installments measured from one month following the grant date of December 14, 2022, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0000899243-22-037804 · doc4.xml · derivative · entry 1

Schmidt Peter · CIK 0001956777 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 300,000

Underlying: Common Stock · 300,000 shares

Expires 2032-12-05

F1 · derivative.exercise_date: This option vests over a four-year period, with 1/48th of the shares subject to the option vesting in substantially equal monthly installments measured from one month following the grant date of December 6, 2022, subject to the Reporting Person's continuous service as of each vesting date.

SEC source: 0000899243-22-035198 · doc4.xml · derivative · entry 1

Andersen Jill · CIK 0001891047 · Chief Legal Officer, Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 175,000

Underlying: Common Stock · 175,000 shares

Expires 2032-11-02

F1 · derivative.exercise_date: This option vests in equal monthly installments over a four-year period measured from one month following November 3, 2022, subject to the Reporting Person's continuous service as of the applicable vesting date.

SEC source: 0000899243-22-034029 · doc4.xml · derivative · entry 1

Lindenboom Christine · CIK 0001950692 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 150,000

Underlying: Common Stock · 150,000 shares

Expires 2032-10-19

F1 · derivative.exercise_date: This option was granted on October 20, 2022 and vests over a three-year period, with one-third of the shares subject to the grant vesting on the first anniversary of the grant date and 1/36th of the shares subject to the grant vesting in equal monthly installments thereafter, subject to the Reporting Person's continued service through each vesting date.

SEC source: 0000899243-22-030183 · doc4.xml · nonDerivative · entry 1

Hering David · CIK 0001875613 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,000

F1 · price: The price in Column 4 is a weighted average purchase price. The prices actually paid ranged from $4.515 to $4.52. The reporting person undertakes to provide upon request by the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.

SEC source: 0000899243-22-029295 · doc4.xml · nonDerivative · entry 3

Elia Marc · CIK 0001830496 · Director · See Footnote 5

M28 Capital Management LP · CIK 0001807489 · See Footnote 5

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 9,248,250

F3 · price: The price in Column 4 is a weighted average purchase price. The prices actually paid ranged from $4.33 to $4.70.

F4 · price: The reporting person undertakes to provide upon request by the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.

F5 · ownership.nature: This Form 4 is filed by M28 Capital Management LP ("M28 Capital Management") and Marc Elia ("Mr. Elia") with respect to securities held by certain funds and accounts for which M28 Capital Management serves as investment manager. Mr. Elia is the Chief Investment Officer of M28 Capital Management and the Managing Member of M28 Capital Management GP LLC, the general partner of M28 Capital Management. Mr. Elia also serves on the Board of Directors of the Issuer. The Reporting Persons expressly disclaim beneficial ownership of the securities reported herein except to the extent of its or his pecuniary interest therein, if any.

SEC source: 0000899243-22-029295 · doc4.xml · nonDerivative · entry 2

Elia Marc · CIK 0001830496 · Director · See Footnote 5

M28 Capital Management LP · CIK 0001807489 · See Footnote 5

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 8,663,799

F2 · price: The price in Column 4 is a weighted average purchase price. The prices actually paid ranged from $3.90 to $4.50.

F4 · price: The reporting person undertakes to provide upon request by the SEC staff, the issuer or a security holder of the issuer, full information regarding the number of shares purchased at each separate price within the range.

F5 · ownership.nature: This Form 4 is filed by M28 Capital Management LP ("M28 Capital Management") and Marc Elia ("Mr. Elia") with respect to securities held by certain funds and accounts for which M28 Capital Management serves as investment manager. Mr. Elia is the Chief Investment Officer of M28 Capital Management and the Managing Member of M28 Capital Management GP LLC, the general partner of M28 Capital Management. Mr. Elia also serves on the Board of Directors of the Issuer. The Reporting Persons expressly disclaim beneficial ownership of the securities reported herein except to the extent of its or his pecuniary interest therein, if any.