ISPC

SEC source: 0001104659-24-103806 · tm2425111-6_4seq1.xml · derivative · entry 1

Paolone Richard · CIK 0002038402 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 168

Underlying: Common Stock · 168 shares

Expires 2034-09-24

F1 · derivative.exercise_date: Represents stock options granted to the reporting person on September 25, 2024, pursuant to the Issuer's Amended and Restated Stock Incentive Plan, and reflects the Issuer's 20-for-1 reverse stock split effective as of 4:30 p.m., Eastern Time, on September 13, 2024. The stock options vest in respect to 84 shares on each of September 30, 2024 and December 31, 2024.

SEC source: 0001104659-24-103805 · tm2425111-5_4seq1.xml · derivative · entry 1

Field Katharyn · CIK 0002029888 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 168

Underlying: Common Stock · 168 shares

Expires 2034-09-24

F1 · derivative.exercise_date: Represents stock options granted to the reporting person on September 25, 2024, pursuant to the Issuer's Amended and Restated Stock Incentive Plan, and reflects the Issuer's 20-for-1 reverse stock split effective as of 4:30 p.m., Eastern Time, on September 13, 2024. The stock options vest in respect to 84 shares on each of September 30, 2024 and December 31, 2024.

SEC source: 0001104659-24-103842 · tm2425111-4_4seq1.xml · derivative · entry 1

Dhaliwal Avtar · CIK 0002038577 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 168

Underlying: Common Stock · 168 shares

Expires 2034-09-24

F1 · derivative.exercise_date: Represents stock options granted to the reporting person on September 25, 2024, pursuant to the Issuer's Amended and Restated Stock Incentive Plan, and reflects the Issuer's 20-for-1 reverse stock split effective as of 4:30 p.m., Eastern Time, on September 13, 2024. The stock options vest in respect to 84 shares on each of September 30, 2024 and December 31, 2024.

SEC source: 0001104659-24-063359 · tm2414962-3_4seq1.xml · derivative · entry 1

Graham Elizabeth Ames · CIK 0001916581 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,340

Underlying: Common Stock · 8,340 shares

Expires 2034-03-20

F1 · derivative.exercise_date: Represents stock options granted to the reporting person on March 21, 2024, pursuant to the Issuer's Amended and Restated Stock Incentive Plan. The stock options vest respect to 2,085 shares on each of March 31, 2024, June 30, 2024, September 30, 2024 and December 31, 2024.

SEC source: 0001104659-24-063360 · tm2414962-4_4seq1.xml · derivative · entry 1

Mock Theresa L · CIK 0001870249 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 16,672

Underlying: Common Stock · 10,000 shares

Expires 2034-01-01

F1 · derivative.exercise_date: Represents stock options granted to the reporting person on January 2, 2024, pursuant to the Issuer's Amended and Restated Stock Incentive Plan. The stock options vest respect to 2,500 shares on each of March 31, 2024, June 30, 2024, September 30, 2024 and December 31, 2024.

SEC source: 0001104659-24-063354 · tm2414962-1_4seq1.xml · derivative · entry 1

Brooks John L. III · CIK 0001343930 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,525

Underlying: Common Stock · 10,000 shares

Expires 2034-01-01

F1 · derivative.exercise_date: Represents stock options granted to the reporting person on January 2, 2024, pursuant to the Issuer's Amended and Restated Stock Incentive Plan. The stock options vest respect to 2,500 shares on each of March 31, 2024, June 30, 2024, September 30, 2024 and December 31, 2024.

SEC source: 0001104659-24-063356 · tm2414962-2_4seq1.xml · derivative · entry 1

Gullans Steven R. Ph.D. · CIK 0001571997 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,525

Underlying: Common Stock · 10,000 shares

Expires 2034-01-01

F1 · derivative.exercise_date: Represents stock options granted to the reporting person on January 2, 2024, pursuant to the Issuer's Amended and Restated Stock Incentive Plan. The stock options vest respect to 2,500 shares on each of March 31, 2024, June 30, 2024, September 30, 2024 and December 31, 2024.

SEC source: 0001104659-24-063361 · tm2414962-5_4seq1.xml · derivative · entry 1

Ross Andrew L. · CIK 0001857013 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 33,525

Underlying: Common Stock · 10,000 shares

Expires 2034-01-01

F1 · derivative.exercise_date: Represents stock options granted to the reporting person on January 2, 2024, pursuant to the Issuer's Amended and Restated Stock Incentive Plan. The stock options vest respect to 2,500 shares on each of March 31, 2024, June 30, 2024, September 30, 2024 and December 31, 2024.

SEC source: 0001104659-23-101210 · tm2326233-1_4seq1.xml · nonDerivative · entry 1

Bielak Benjamin · CIK 0001857054 · Chief Info Officer & Secretary

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 84,348

F1 · shares: Reflects an open market purchase of shares of the Issuer's common stock by the Reporting Person.

SEC source: 0001104659-23-067152 · tm2317620-1_4seq1.xml · nonDerivative · entry 1

Curley Tracy · CIK 0001857028 · Director · CEO, CFO and Treasurer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 49,541

F1 · security: Reflects an open market purchase of shares of the Issuer's common stock by the Reporting Person.

F1 · shares: Reflects an open market purchase of shares of the Issuer's common stock by the Reporting Person.

SEC source: 0001104659-23-004999 · tm233905-2_4seq1.xml · derivative · entry 2

Mullan Jill · CIK 0001857039 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 66,637 shares

Expires 2023-01-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Represents the stock options that were vested on the date of termination of employment of the Reporting Person and will expire if not exercised by the Reporting Person before January 22, 2023.

F4 · balance_after: Represents remaining granted stock options across all grants.

SEC source: 0001104659-23-004999 · tm233905-2_4seq1.xml · nonDerivative · entry 1

Mullan Jill · CIK 0001857039 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 246,226

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquisition of shares of common stock by the Reporting Person upon the exercise of stock options.

F2 · price: Represents the $1.00 exercise price per share of the stock options exercised, which was paid by the Reporting Person upon exercise of such stock options.

SEC source: 0001104659-23-005104 · tm233905-3_4seq1.xml · derivative · entry 3

Ianelli Christopher · CIK 0001857027 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 845 shares

Expires 2023-01-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Represents the stock options that were vested on the date of termination of employment of the Reporting Person and will expire if not exercised by the Reporting Person before January 22, 2023.

F4 · balance_after: Represents remaining granted stock options across all grants.

SEC source: 0001104659-23-005104 · tm233905-3_4seq1.xml · nonDerivative · entry 1

Ianelli Christopher · CIK 0001857027 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 425,359

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquisition of shares of common stock by the Reporting Person upon the exercise of stock options.

SEC source: 0001104659-23-003745 · tm233286-3_4seq1.xml · derivative · entry 1

Brooks John L · CIK 0001343930 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,525

Underlying: Common Stock · 10,000 shares

Expires 2033-01-03

F1 · derivative.exercise_date: Represents stock options granted to the reporting person on January 3, 2023, pursuant to the Issuer's Amended and Restated Stock Incentive Plan. The stock options vest respect to 2,500 shares on each of March 31, 2023, June 30, 2023, September 30, 2023 and December 31, 2023.

SEC source: 0001104659-23-003744 · tm233286-2_4seq1.xml · derivative · entry 1

Scholl George H. · CIK 0001857026 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,525

Underlying: Common Stock · 10,000 shares

Expires 2033-01-03

F1 · derivative.exercise_date: Represents stock options granted to the reporting person on January 3, 2023, pursuant to the Issuer's Amended and Restated Stock Incentive Plan. The stock options vest respect to 2,500 shares on each of March 31, 2023, June 30, 2023, September 30, 2023 and December 31, 2023.

SEC source: 0001104659-23-003747 · tm233286-5_4seq1.xml · derivative · entry 1

Gullans Steven R. Ph.D. · CIK 0001571997 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,525

Underlying: Common Stock · 10,000 shares

Expires 2033-01-03

F1 · derivative.exercise_date: Represents stock options granted to the reporting person on January 3, 2023, pursuant to the Issuer's Amended and Restated Stock Incentive Plan. The stock options vest respect to 2,500 shares on each of March 31, 2023, June 30, 2023, September 30, 2023 and December 31, 2023.

SEC source: 0001104659-23-003746 · tm233286-4_4seq1.xml · derivative · entry 1

Basile Joseph J. · CIK 0001954843 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,668

Underlying: Common Stock · 10,000 shares

Expires 2033-01-03

F1 · derivative.exercise_date: Represents stock options granted to the reporting person on January 3, 2023, pursuant to the Issuer's Amended and Restated Stock Incentive Plan. The stock options vest respect to 2,500 shares on each of March 31, 2023, June 30, 2023, September 30, 2023 and December 31, 2023.

SEC source: 0001104659-23-003742 · tm233286-1_4seq1.xml · derivative · entry 1

Ross Andrew L. · CIK 0001857013 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,525

Underlying: Common Stock · 10,000 shares

Expires 2033-01-03

F1 · derivative.exercise_date: Represents stock options granted to the reporting person on January 3, 2023, pursuant to the Issuer's Amended and Restated Stock Incentive Plan. The stock options vest respect to 2,500 shares on each of March 31, 2023, June 30, 2023, September 30, 2023 and December 31, 2023.

SEC source: 0001104659-23-004998 · tm233905-1_4seq1.xml · derivative · entry 1

Mullan Jill · CIK 0001857039 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 76,637

Underlying: Common Stock · 10,000 shares

Expires 2033-01-03

F1 · derivative.exercise_date: Represents stock options granted to the reporting person on January 3, 2023, pursuant to the Issuer's Amended and Restated 2021 Stock Incentive Plan. The stock options vest with respect to 2,500 shares on each of March 31, 2023, June 30, 2023, September 30, 2023 and December 31, 2023.

F2 · balance_after: Represents remaining granted stock options across all grants.

SEC source: 0001104659-23-005104 · tm233905-3_4seq1.xml · derivative · entry 2

Ianelli Christopher · CIK 0001857027 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,845

Underlying: Common Stock · 10,000 shares

Expires 2033-01-03

F2 · derivative.exercise_date: Represents stock options granted to the reporting person on January 3, 2023, pursuant to the Issuer's Amended and Restated Stock Incentive Plan. The stock options vest with respect to 2,500 shares on each of March 31, 2023, June 30, 2023, September 30, 2023 and December 31, 2023.

SEC source: 0001104659-23-061741 · tm2315065-6_4seq1.xml · nonDerivative · entry 1

Brooks John L. III · CIK 0001343930 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,250

F1 · security: Reflects shares of common stock issued to the Reporting Person upon vesting and settlement of restricted stock units ("RSUs") on March 31, 2023, which RSUs were awarded to the Reporting Person as of January 1, 2023, subject to the terms and conditions set forth in the award of such RSUs by the Issuer to the Reporting Person pursuant to a Restricted Stock Unit Award Agreement.

F1 · shares: Reflects shares of common stock issued to the Reporting Person upon vesting and settlement of restricted stock units ("RSUs") on March 31, 2023, which RSUs were awarded to the Reporting Person as of January 1, 2023, subject to the terms and conditions set forth in the award of such RSUs by the Issuer to the Reporting Person pursuant to a Restricted Stock Unit Award Agreement.

F2 · price: The RSUs were awarded as compensation to the Reporting Person for his service as a director of the Company.

SEC source: 0001104659-23-061740 · tm2315065-5_4seq1.xml · nonDerivative · entry 1

Mullan Jill · CIK 0001857039 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 246,318

F1 · security: Reflects shares of common stock issued to the Reporting Person upon vesting and settlement of restricted stock units ("RSUs") on March 31, 2023, which RSUs were awarded to the Reporting Person as of January 1, 2023, subject to the terms and conditions set forth in the award of such RSUs by the Issuer to the Reporting Person pursuant to a Restricted Stock Unit Award Agreement.

F1 · shares: Reflects shares of common stock issued to the Reporting Person upon vesting and settlement of restricted stock units ("RSUs") on March 31, 2023, which RSUs were awarded to the Reporting Person as of January 1, 2023, subject to the terms and conditions set forth in the award of such RSUs by the Issuer to the Reporting Person pursuant to a Restricted Stock Unit Award Agreement.

F2 · price: The RSUs were awarded as compensation to the Reporting Person for his service as a director of the Company.

SEC source: 0001104659-23-061742 · tm2315065-7_4seq1.xml · nonDerivative · entry 1

Basile Joseph J. · CIK 0001954843 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 63

F1 · security: Reflects shares of common stock issued to the Reporting Person upon vesting and settlement of restricted stock units ("RSUs") on March 31, 2023, which RSUs were awarded to the Reporting Person as of January 1, 2023, subject to the terms and conditions set forth in the award of such RSUs by the Issuer to the Reporting Person pursuant to a Restricted Stock Unit Award Agreement.

F1 · shares: Reflects shares of common stock issued to the Reporting Person upon vesting and settlement of restricted stock units ("RSUs") on March 31, 2023, which RSUs were awarded to the Reporting Person as of January 1, 2023, subject to the terms and conditions set forth in the award of such RSUs by the Issuer to the Reporting Person pursuant to a Restricted Stock Unit Award Agreement.

F2 · price: The RSUs were awarded as compensation to the Reporting Person for his service as a director of the Company.

SEC source: 0001104659-23-061736 · tm2315065-1_4seq1.xml · nonDerivative · entry 1

Gullans Steven R. Ph.D. · CIK 0001571997 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 3,250

F1 · security: Reflects shares of common stock issued to the Reporting Person upon vesting and settlement of restricted stock units ("RSUs") on March 31, 2023, which RSUs were awarded to the Reporting Person as of January 1, 2023, subject to the terms and conditions set forth in the award of such RSUs by the Issuer to the Reporting Person pursuant to a Restricted Stock Unit Award Agreement.

F1 · shares: Reflects shares of common stock issued to the Reporting Person upon vesting and settlement of restricted stock units ("RSUs") on March 31, 2023, which RSUs were awarded to the Reporting Person as of January 1, 2023, subject to the terms and conditions set forth in the award of such RSUs by the Issuer to the Reporting Person pursuant to a Restricted Stock Unit Award Agreement.

F2 · price: The RSUs were awarded as compensation to the Reporting Person for his service as a director of the Company.

SEC source: 0001104659-23-061739 · tm2315065-3_4seq1.xml · nonDerivative · entry 1

Ianelli Christopher · CIK 0001857027 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 425,451

F1 · security: Reflects shares of common stock issued to the Reporting Person upon vesting and settlement of restricted stock units ("RSUs") on March 31, 2023, which RSUs were awarded to the Reporting Person as of January 1, 2023, subject to the terms and conditions set forth in the award of such RSUs by the Issuer to the Reporting Person pursuant to a Restricted Stock Unit Award Agreement.

F1 · shares: Reflects shares of common stock issued to the Reporting Person upon vesting and settlement of restricted stock units ("RSUs") on March 31, 2023, which RSUs were awarded to the Reporting Person as of January 1, 2023, subject to the terms and conditions set forth in the award of such RSUs by the Issuer to the Reporting Person pursuant to a Restricted Stock Unit Award Agreement.

F2 · price: The RSUs were awarded as compensation to the Reporting Person for his service as a director of the Company.

SEC source: 0001104659-23-061737 · tm2315065-2_4seq1.xml · nonDerivative · entry 1

Ross Andrew L. · CIK 0001857013 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,326,340

F1 · security: Reflects shares of common stock issued to the Reporting Person upon vesting and settlement of restricted stock units ("RSUs") on March 31, 2023, which RSUs were awarded to the Reporting Person as of January 1, 2023, subject to the terms and conditions set forth in the award of such RSUs by the Issuer to the Reporting Person pursuant to a Restricted Stock Unit Award Agreement.

F1 · shares: Reflects shares of common stock issued to the Reporting Person upon vesting and settlement of restricted stock units ("RSUs") on March 31, 2023, which RSUs were awarded to the Reporting Person as of January 1, 2023, subject to the terms and conditions set forth in the award of such RSUs by the Issuer to the Reporting Person pursuant to a Restricted Stock Unit Award Agreement.

F2 · price: The RSUs were awarded as compensation to the Reporting Person for his service as a director of the Company.

SEC source: 0001104659-22-114982 · tm2229745-2_4seq1.xml · derivative · entry 1

Curley Tracy · CIK 0001857028 · Interim CEO, CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2032-11-01

F1 · derivative.exercise_price: Represents 91,235 and 8,765 options granted on November 1, 2022 under the Issuer's 2013 Stock Incentive Plan and the 2021 Stock Incentive Plan, respectively, 25% of which were subject to a one-year cliff with the remaining 75% vested/to be vested quarterly over three years. The vesting commence date is October 24, 2022. The stock options were awarded as compensation to the Reporting Person for her service as an officer of the Company.

F1 · derivative.exercise_date: Represents 91,235 and 8,765 options granted on November 1, 2022 under the Issuer's 2013 Stock Incentive Plan and the 2021 Stock Incentive Plan, respectively, 25% of which were subject to a one-year cliff with the remaining 75% vested/to be vested quarterly over three years. The vesting commence date is October 24, 2022. The stock options were awarded as compensation to the Reporting Person for her service as an officer of the Company.

SEC source: 0001104659-22-114980 · tm2229745-1_4seq1.xml · derivative · entry 1

Bielak Benjamin · CIK 0001857054 · Chief Information Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 57,952

Underlying: Common Stock · 30,000 shares

Expires 2032-11-01

F1 · derivative.exercise_price: Represents stock options granted on November 1, 2022 under the Issuer's 2013 Stock Incentive Plan, 25% of which were subject to a one-year cliff with the remaining 75% vested/to be vested quarterly over three years. The vesting commence date is June 21, 2022. The stock options were awarded as compensation to the Reporting Person for his service as an officer of the Company.

F1 · derivative.exercise_date: Represents stock options granted on November 1, 2022 under the Issuer's 2013 Stock Incentive Plan, 25% of which were subject to a one-year cliff with the remaining 75% vested/to be vested quarterly over three years. The vesting commence date is June 21, 2022. The stock options were awarded as compensation to the Reporting Person for his service as an officer of the Company.

SEC source: 0001104659-22-117133 · tm2230264-1_4seq1.xml · derivative · entry 2

Mullan Jill · CIK 0001857039 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 66,637

Underlying: Common Stock · 564 shares

Expires 2022-10-24

F3 · derivative.exercise_price: Represents unvested stock options that were forfeited upon the termination of employment of the reporting person with the issuer. Stock options exercisable for an aggregate of 66,637 shares that were vested on the date of termination of employment of the reporting person will expire on January 22, 2023, if not exercised by the reporting person before that date.

F3 · price: Represents unvested stock options that were forfeited upon the termination of employment of the reporting person with the issuer. Stock options exercisable for an aggregate of 66,637 shares that were vested on the date of termination of employment of the reporting person will expire on January 22, 2023, if not exercised by the reporting person before that date.

F3 · derivative.exercise_date: Represents unvested stock options that were forfeited upon the termination of employment of the reporting person with the issuer. Stock options exercisable for an aggregate of 66,637 shares that were vested on the date of termination of employment of the reporting person will expire on January 22, 2023, if not exercised by the reporting person before that date.

SEC source: 0001104659-22-117133 · tm2230264-1_4seq1.xml · nonDerivative · entry 1

Mullan Jill · CIK 0001857039 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 179,589

F1 · security: Pursuant to certain separation agreement, dated October 24, 2022 (the "Separation Agreement"), by and between the issuer and the reporting person, (i) an aggregate of 13,021 restricted stock units of the issuer (the "RSUs"), which were previously awarded to the reporting person but not settled, were settled at an accelerated vesting schedule and as a result, 13,021 shares of common stock were issued to the reporting person; and (ii) 18,229 RSUs, which were previously awarded to the reporting person and not settled, were forfeited.

F1 · kind: Pursuant to certain separation agreement, dated October 24, 2022 (the "Separation Agreement"), by and between the issuer and the reporting person, (i) an aggregate of 13,021 restricted stock units of the issuer (the "RSUs"), which were previously awarded to the reporting person but not settled, were settled at an accelerated vesting schedule and as a result, 13,021 shares of common stock were issued to the reporting person; and (ii) 18,229 RSUs, which were previously awarded to the reporting person and not settled, were forfeited.

F2 · price: The RSUs were previously awarded as compensation to the reporting person for her former service as an officer of the issuer.

SEC source: 0001104659-22-117765 · tm2230264-2_4seq1.xml · derivative · entry 2

Ianelli Christopher · CIK 0001857027 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 845

Underlying: Common Stock · 564 shares

Expires 2022-10-24

F3 · derivative.exercise_price: Represents unvested stock options that were forfeited upon the termination of employment of the reporting person with the issuer. Stock options exercisable for an aggregate of 845 shares that were vested on the date of termination of employment of the reporting person will expire on January 22, 2023, if not exercised by the reporting person before that date.

F3 · price: Represents unvested stock options that were forfeited upon the termination of employment of the reporting person with the issuer. Stock options exercisable for an aggregate of 845 shares that were vested on the date of termination of employment of the reporting person will expire on January 22, 2023, if not exercised by the reporting person before that date.

F3 · derivative.exercise_date: Represents unvested stock options that were forfeited upon the termination of employment of the reporting person with the issuer. Stock options exercisable for an aggregate of 845 shares that were vested on the date of termination of employment of the reporting person will expire on January 22, 2023, if not exercised by the reporting person before that date.

SEC source: 0001104659-22-117765 · tm2230264-2_4seq1.xml · nonDerivative · entry 1

Ianelli Christopher · CIK 0001857027 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 424,514

F1 · security: Pursuant to certain separation agreement, dated October 24, 2022, by and between the issuer and the reporting person, (i) an aggregate of 13,021 restricted stock units of the issuer (the "RSUs"), which were previously awarded to the reporting person but not settled, were settled at an accelerated vesting schedule and as a result, 13,021 shares of common stock were issued to the reporting person; and (ii) 18,229 RSUs, which were previously awarded to the reporting person and not settled, were forfeited.

F1 · kind: Pursuant to certain separation agreement, dated October 24, 2022, by and between the issuer and the reporting person, (i) an aggregate of 13,021 restricted stock units of the issuer (the "RSUs"), which were previously awarded to the reporting person but not settled, were settled at an accelerated vesting schedule and as a result, 13,021 shares of common stock were issued to the reporting person; and (ii) 18,229 RSUs, which were previously awarded to the reporting person and not settled, were forfeited.

F2 · price: The RSUs were previously awarded as compensation to the reporting person for his former service as an officer of the issuer.

SEC source: 0001104659-23-018754 · tm236233-1_5seq1.xml · nonDerivative · entry 1

Brooks John L · CIK 0001343930 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,125

F1 · security: Represents shares underlying certain restricted stock units ("RSUs"), each of which is a contingent right to receive one share of common stock at settlement subject to the terms and conditions set forth in the award of such RSUs by the Issuer to the Reporting Person pursuant to a Restricted Stock Unit Award Agreement (the "RSU Agreement"). 625 RSUs vested in one installment on December 31, 2022 and were settled on January 3, 2023, subject to the terms and conditions set forth in the RSU Agreement and as a result, 625 shares of common stock were issued to the Reporting Person.

F1 · shares: Represents shares underlying certain restricted stock units ("RSUs"), each of which is a contingent right to receive one share of common stock at settlement subject to the terms and conditions set forth in the award of such RSUs by the Issuer to the Reporting Person pursuant to a Restricted Stock Unit Award Agreement (the "RSU Agreement"). 625 RSUs vested in one installment on December 31, 2022 and were settled on January 3, 2023, subject to the terms and conditions set forth in the RSU Agreement and as a result, 625 shares of common stock were issued to the Reporting Person.

F2 · price: The RSUs were awarded as compensation to the Reporting Person for his service as a director of the Company.

SEC source: 0001104659-23-018759 · tm236233-5_5seq1.xml · nonDerivative · entry 1

Lawrence Margaret H. · CIK 0001857015 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,125

F1 · security: Represents shares underlying certain restricted stock units ("RSUs"), each of which is a contingent right to receive one share of common stock at settlement subject to the terms and conditions set forth in the award of such RSUs by the Company to the Reporting Person pursuant to a Restricted Stock Unit Award Agreement (the "RSU Agreement"). The RSUs vests in one installment, on December 31, 2022, subject to the terms and conditions set forth in the RSU Agreement. 625 RSUs were settled for shares of common stock on December 31, 2022, and the Reporting Person was issued 625 shares of common stock.

F1 · shares: Represents shares underlying certain restricted stock units ("RSUs"), each of which is a contingent right to receive one share of common stock at settlement subject to the terms and conditions set forth in the award of such RSUs by the Company to the Reporting Person pursuant to a Restricted Stock Unit Award Agreement (the "RSU Agreement"). The RSUs vests in one installment, on December 31, 2022, subject to the terms and conditions set forth in the RSU Agreement. 625 RSUs were settled for shares of common stock on December 31, 2022, and the Reporting Person was issued 625 shares of common stock.

F2 · price: The RSUs were awarded as compensation to the Reporting Person for his service as a director of the Company.

SEC source: 0001104659-23-018757 · tm236233-4_5seq1.xml · nonDerivative · entry 1

Scholl George H. · CIK 0001857026 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,125

F1 · security: Represents shares underlying certain restricted stock units ("RSUs"), each of which is a contingent right to receive one share of common stock at settlement subject to the terms and conditions set forth in the award of such RSUs by the Issuer to the Reporting Person pursuant to a Restricted Stock Unit Award Agreement (the "RSU Agreement"). 625 RSUs vested in one installment on December 31, 2022 and were settled on January 3, 2023, subject to the terms and conditions set forth in the RSU Agreement and as a result, 625 shares of common stock were issued to the Reporting Person.

F1 · shares: Represents shares underlying certain restricted stock units ("RSUs"), each of which is a contingent right to receive one share of common stock at settlement subject to the terms and conditions set forth in the award of such RSUs by the Issuer to the Reporting Person pursuant to a Restricted Stock Unit Award Agreement (the "RSU Agreement"). 625 RSUs vested in one installment on December 31, 2022 and were settled on January 3, 2023, subject to the terms and conditions set forth in the RSU Agreement and as a result, 625 shares of common stock were issued to the Reporting Person.

F2 · price: The RSUs were awarded as compensation to the Reporting Person for his service as a director of the Company.

SEC source: 0001104659-23-018756 · tm236233-3_5seq1.xml · nonDerivative · entry 1

Ross Andrew L. · CIK 0001857013 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,326,215

F1 · security: Represents shares underlying certain restricted stock units ("RSUs"), each of which is a contingent right to receive one share of common stock at settlement subject to the terms and conditions set forth in the award of such RSUs by the Issuer to the Reporting Person pursuant to a Restricted Stock Unit Award Agreement (the "RSU Agreement"). 625 RSUs vested in one installment on December 31, 2022 and were settled on January 3, 2023, subject to the terms and conditions set forth in the RSU Agreement and as a result, 625 shares of common stock were issued to the Reporting Person.

F1 · shares: Represents shares underlying certain restricted stock units ("RSUs"), each of which is a contingent right to receive one share of common stock at settlement subject to the terms and conditions set forth in the award of such RSUs by the Issuer to the Reporting Person pursuant to a Restricted Stock Unit Award Agreement (the "RSU Agreement"). 625 RSUs vested in one installment on December 31, 2022 and were settled on January 3, 2023, subject to the terms and conditions set forth in the RSU Agreement and as a result, 625 shares of common stock were issued to the Reporting Person.

F2 · price: The RSUs were awarded as compensation to the Reporting Person for his service as a director of the Company.

SEC source: 0001104659-23-018755 · tm236233-2_5seq1.xml · nonDerivative · entry 1

Gullans Steven R. Ph.D. · CIK 0001571997 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,125

F1 · security: Represents shares underlying certain restricted stock units ("RSUs"), each of which is a contingent right to receive one share of common stock at settlement subject to the terms and conditions set forth in the award of such RSUs by the Issuer to the Reporting Person pursuant to a Restricted Stock Unit Award Agreement (the "RSU Agreement"). 625 RSUs vested in one installment on December 31, 2022 and were settled on January 3, 2023, subject to the terms and conditions set forth in the RSU Agreement and as a result, 625 shares of common stock were issued to the Reporting Person.

F1 · shares: Represents shares underlying certain restricted stock units ("RSUs"), each of which is a contingent right to receive one share of common stock at settlement subject to the terms and conditions set forth in the award of such RSUs by the Issuer to the Reporting Person pursuant to a Restricted Stock Unit Award Agreement (the "RSU Agreement"). 625 RSUs vested in one installment on December 31, 2022 and were settled on January 3, 2023, subject to the terms and conditions set forth in the RSU Agreement and as a result, 625 shares of common stock were issued to the Reporting Person.

F2 · price: The RSUs were awarded as compensation to the Reporting Person for his service as a director of the Company.

SEC source: 0001104659-22-074371 · tm2219397-4_4seq1.xml · nonDerivative · entry 1

Curley Tracy · CIK 0001857028 · CFO and Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,141

F1 · kind: The shares were sold and the proceeds were paid to the Issuer to satisfy tax withholding obligations.

SEC source: 0001104659-22-074368 · tm2219397-2_4seq1.xml · nonDerivative · entry 1

Ianelli Christopher · CIK 0001857027 · Director · CEO and President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 442,743

F1 · kind: The shares were sold and the proceeds were paid to the Issuer to satisfy tax withholding obligations.

SEC source: 0001104659-22-074370 · tm2219397-3_4seq1.xml · nonDerivative · entry 1

Mullan Jill · CIK 0001857039 · Director · COO and Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 197,818

F1 · kind: The shares were sold and the proceeds were paid to the Issuer to satisfy tax withholding obligations.

SEC source: 0001104659-22-074366 · tm2219397-1_4seq1.xml · nonDerivative · entry 1

Bielak Benjamin · CIK 0001857054 · Chief Information Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 66,348

F1 · kind: The shares were sold and the proceeds were paid to the Issuer to satisfy tax withholding obligations.

SEC source: 0001104659-22-026697 · tm227646-1_4seq1.xml · derivative · entry 4

Ianelli Christopher · CIK 0001857027 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,409

Underlying: Common Stock · 48,106 shares

Expires 2029-07-12

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: Represents the stock options granted to the Reporting Person on July 13, 2019, pursuant to the Issuer's 2010 Stock Incentive Plan, which were fully vested on July 14, 2019.

F5 · balance_after: Represents remaining granted stock options across all grants.

SEC source: 0001104659-22-026697 · tm227646-1_4seq1.xml · nonDerivative · entry 2

Ianelli Christopher · CIK 0001857027 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 446,646

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquisition of shares of common stock by the Reporting Person upon the exercise of stock options.

F2 · price: Represents the $1.00 exercise price per share of the stock options exercised, which was paid by the Reporting Person upon exercise of such stock options.

SEC source: 0001104659-22-026191 · tm227509-1_4seq1.xml · derivative · entry 4

Mullan Jill · CIK 0001857039 · Director · COO & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 67,201

Underlying: Common Stock · 3,099 shares

Expires 2029-01-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: Represents a portion of the stock options granted to the Reporting Person on February 1, 2019, pursuant to the Issuer's 2013 Stock Incentive Plan, which were fully vested on February 1, 2022.

F5 · balance_after: Represents remaining granted stock options across all grants.

SEC source: 0001104659-22-026191 · tm227509-1_4seq1.xml · derivative · entry 3

Mullan Jill · CIK 0001857039 · Director · COO & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 70,300

Underlying: Common Stock · 19,296 shares

Expires 2026-06-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Represents a portion of the stock options granted to the Reporting Person on June 30, 2016, pursuant to the Issuer's 2013 Stock Incentive Plan, which were fully vested on June 30, 2019.

F5 · balance_after: Represents remaining granted stock options across all grants.

SEC source: 0001104659-22-026191 · tm227509-1_4seq1.xml · nonDerivative · entry 2

Mullan Jill · CIK 0001857039 · Director · COO & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 200,942

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquisition of shares of common stock by the Reporting Person upon the exercise of stock options.

F2 · price: Represents the $1.00 exercise price per share of the stock options exercised, which was paid by the Reporting Person upon exercise of such stock options.

SEC source: 0001104659-22-026191 · tm227509-1_4seq1.xml · nonDerivative · entry 1

Mullan Jill · CIK 0001857039 · Director · COO & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 197,843

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquisition of shares of common stock by the Reporting Person upon the exercise of stock options.

F2 · price: Represents the $1.00 exercise price per share of the stock options exercised, which was paid by the Reporting Person upon exercise of such stock options.

SEC source: 0001104659-22-026697 · tm227646-1_4seq1.xml · derivative · entry 3

Ianelli Christopher · CIK 0001857027 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 49,515

Underlying: Common Stock · 3,099 shares

Expires 2029-01-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Represents a portion of the stock options granted to the Reporting Person on April 26, 2019, pursuant to the Issuer's 2013 Stock Incentive Plan, which were fully vested on November 30, 2021.

F5 · balance_after: Represents remaining granted stock options across all grants.

SEC source: 0001104659-22-026697 · tm227646-1_4seq1.xml · nonDerivative · entry 1

Ianelli Christopher · CIK 0001857027 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 398,540

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquisition of shares of common stock by the Reporting Person upon the exercise of stock options.

F2 · price: Represents the $1.00 exercise price per share of the stock options exercised, which was paid by the Reporting Person upon exercise of such stock options.