IRTC

SEC source: 0000899243-17-018207 · doc4.xml · derivative · entry 3

Garrett Matthew C. · CIK 0001668499 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,910

Underlying: Common Stock · 25,086 shares

Expires 2023-01-24

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0000899243-17-018207 · doc4.xml · nonDerivative · entry 2

Garrett Matthew C. · CIK 0001668499 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,630

F1 · kind: The option exercises and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 8, 2017.

F3 · price: This transaction was executed in multiple trades at prices ranging from $41.67 to $42.43. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · balance_after: Includes 630 shares acquired under the IRTC stock purchase plan on June 1, 2017.

SEC source: 0000899243-17-018207 · doc4.xml · nonDerivative · entry 1

Garrett Matthew C. · CIK 0001668499 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 39,716

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercises and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 8, 2017.

F2 · balance_after: Includes 630 shares acquired under the IRTC stock purchase plan on June 1, 2017.

SEC source: 0000899243-17-018208 · doc4.xml · derivative · entry 5

King Kevin M · CIK 0001385014 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 267,813

Underlying: Common Stock · 110,000 shares

Expires 2022-09-27

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · date: 100,290 shares were exercised on July 10, 2017 and 9,710 shares were exercised on July 11, 2017.

SEC source: 0000899243-17-018208 · doc4.xml · nonDerivative · entry 2

King Kevin M · CIK 0001385014 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 43,042

F1 · kind: The option exercises and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 8, 2017.

F3 · price: This transaction was executed in multiple trades at prices ranging from $41.80 to $42.40. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

F2 · balance_after: Includes 1,042 shares acquired under the IRTC stock purchase plan on June 1, 2017.

SEC source: 0000899243-17-018208 · doc4.xml · nonDerivative · entry 1

King Kevin M · CIK 0001385014 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 143,332

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The option exercises and sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 8, 2017.

F2 · balance_after: Includes 1,042 shares acquired under the IRTC stock purchase plan on June 1, 2017.

SEC source: 0001012975-17-000480 · edgar.xml · nonDerivative · entry 2

Lathi Vijay K · CIK 0001340806 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 665,965

F3 · price: The price reported in Column 4 is a weighted average price (gross of commissions). These shares were sold in multiple transactions at prices ranging from $38.00 to $38.35, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

F2 · ownership.nature: Represents shares directly beneficially owned by New Leaf Ventures II, L.P. ("NLV II"). The Reporting Person is an individual manager of New Leaf Venture Management II, L.L.C. ("Management II"). Management II is the general partner of New Leaf Venture Associates II, L.P. ("Associates II"). Associates II is the general partner of NLV II. As such, the Reporting Person shares voting and dispositive control with respect to the shares held by NLV II. The Reporting Person disclaims beneficial ownership of the shares held by NLV II, except to the extent of his proportionate pecuniary interest therein.

SEC source: 0001209191-17-039009 · doc4.xml · nonDerivative · entry 2

SYNERGY LIFE SCIENCE PARTNERS L P · CIK 0001384771 · 10% owner

Synergy Venture Partners, LLC · CIK 0001584405 · 10% owner

Jain Mudit K. · CIK 0001584404 · 10% owner

Starling William N JR · CIK 0001324130 · 10% owner

Stack Richard S. · CIK 0001584403 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Synergy Life Science Partners, LP

Disclosed balance after: 2,034,524

F3 · price: Price reflected is the weighted-average sale price for shares sold. The range of sale prices for the transactions reported was $37.65 to $38.54 per share. The Reporting Person undertakes to provide, upon request by the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F2 · ownership.nature: Synergy Venture Partners, LLC ("SVP LLC") serves as the sole General Partner of Synergy Life Science Partners, LP ("Synergy"). As such, SVP LLC possesses sole voting and investment control over the securities owned by Synergy, and may be deemed to have indirect beneficial ownership of the securities held by Synergy. SVP LLC, however, owns no securities of the Issuer directly. Messrs. Stack, Jain and Starling are Managers of SVP LLC and share voting and dispositive power over the shares held by Synergy. Each Reporting Person disclaims beneficial ownership of the shares held by Synergy except to the extent of his or its proportionate pecuniary interest therein.

SEC source: 0001209191-17-039009 · doc4.xml · nonDerivative · entry 1

SYNERGY LIFE SCIENCE PARTNERS L P · CIK 0001384771 · 10% owner

Synergy Venture Partners, LLC · CIK 0001584405 · 10% owner

Jain Mudit K. · CIK 0001584404 · 10% owner

Starling William N JR · CIK 0001324130 · 10% owner

Stack Richard S. · CIK 0001584403 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Synergy Life Science Partners, LP

Disclosed balance after: 2,112,712

F1 · price: Price reflected is the weighted-average sale price for shares sold. The range of sale prices for the transactions reported was $37.00 to $37.58 per share. The Reporting Person undertakes to provide, upon request by the SEC staff, the Issuer, or a security holder of the Issuer, full information regarding the number of shares sold at each separate price.

F2 · ownership.nature: Synergy Venture Partners, LLC ("SVP LLC") serves as the sole General Partner of Synergy Life Science Partners, LP ("Synergy"). As such, SVP LLC possesses sole voting and investment control over the securities owned by Synergy, and may be deemed to have indirect beneficial ownership of the securities held by Synergy. SVP LLC, however, owns no securities of the Issuer directly. Messrs. Stack, Jain and Starling are Managers of SVP LLC and share voting and dispositive power over the shares held by Synergy. Each Reporting Person disclaims beneficial ownership of the shares held by Synergy except to the extent of his or its proportionate pecuniary interest therein.

SEC source: 0001012975-17-000480 · edgar.xml · nonDerivative · entry 1

Lathi Vijay K · CIK 0001340806 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 957,965

F1 · price: The price reported in Column 4 is a weighted average price (gross of commissions). These shares were sold in multiple transactions at prices ranging from $36.50 to $36.71, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

F2 · ownership.nature: Represents shares directly beneficially owned by New Leaf Ventures II, L.P. ("NLV II"). The Reporting Person is an individual manager of New Leaf Venture Management II, L.L.C. ("Management II"). Management II is the general partner of New Leaf Venture Associates II, L.P. ("Associates II"). Associates II is the general partner of NLV II. As such, the Reporting Person shares voting and dispositive control with respect to the shares held by NLV II. The Reporting Person disclaims beneficial ownership of the shares held by NLV II, except to the extent of his proportionate pecuniary interest therein.

SEC source: 0000899243-17-018073 · doc4.xml · derivative · entry 2

TALWALKAR ABHIJIT Y · CIK 0001316065 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,982

Underlying: Common Stock · 2,982 shares

Expires 2027-05-23

F2 · derivative.exercise_date: The option vests in twelve equal monthly installments beginning on June 23, 2017.

SEC source: 0000899243-17-018073 · doc4.xml · nonDerivative · entry 1

TALWALKAR ABHIJIT Y · CIK 0001316065 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,435

F1 · shares: The reported securities are represented by restricted stock units ("RSUs"), which represents a contingent right to receive shares of IRTC common stock. The RSUs fully vest on May 23, 2018.

SEC source: 0001012975-17-000441 · edgar.xml · nonDerivative · entry 4

Lathi Vijay K · CIK 0001340806 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 1,096,589

F1 · ownership.nature: Represents shares directly beneficially owned by New Leaf Ventures II, L.P. ("NLV II"). The Reporting Person is an individual manager of New Leaf Venture Management II, L.L.C. ("Management II"). Management II is the general partner of New Leaf Venture Associates II, L.P. ("Associates II"). Associates II is the general partner of NLV II. As such, the Reporting Person shares voting and dispositive control with respect to the shares held by NLV II. The Reporting Person disclaims beneficial ownership of the shares held by NLV II, except to the extent of his proportionate pecuniary interest therein.

SEC source: 0001012975-17-000441 · edgar.xml · nonDerivative · entry 3

Lathi Vijay K · CIK 0001340806 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 1,226,589

F2 · price: The price reported in Column 4 is a weighted average price (net of commissions). These shares were sold in multiple transactions at prices ranging from $36.06 to $36.59, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

F1 · ownership.nature: Represents shares directly beneficially owned by New Leaf Ventures II, L.P. ("NLV II"). The Reporting Person is an individual manager of New Leaf Venture Management II, L.L.C. ("Management II"). Management II is the general partner of New Leaf Venture Associates II, L.P. ("Associates II"). Associates II is the general partner of NLV II. As such, the Reporting Person shares voting and dispositive control with respect to the shares held by NLV II. The Reporting Person disclaims beneficial ownership of the shares held by NLV II, except to the extent of his proportionate pecuniary interest therein.

SEC source: 0001012975-17-000441 · edgar.xml · nonDerivative · entry 2

Lathi Vijay K · CIK 0001340806 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 1,306,589

F1 · ownership.nature: Represents shares directly beneficially owned by New Leaf Ventures II, L.P. ("NLV II"). The Reporting Person is an individual manager of New Leaf Venture Management II, L.L.C. ("Management II"). Management II is the general partner of New Leaf Venture Associates II, L.P. ("Associates II"). Associates II is the general partner of NLV II. As such, the Reporting Person shares voting and dispositive control with respect to the shares held by NLV II. The Reporting Person disclaims beneficial ownership of the shares held by NLV II, except to the extent of his proportionate pecuniary interest therein.

SEC source: 0001209191-17-032087 · doc4.xml · nonDerivative · entry 2

de Clercq Casper L. · CIK 0001614601 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Limited Partnership

Disclosed balance after: 0

F3 · kind: Shares were disposed via pro rata in-kind distribution of Issuer's common stock from Norwest Venture Partners XII, LP ("NVP XII") to its limited and general partners.

F3 · price: Shares were disposed via pro rata in-kind distribution of Issuer's common stock from Norwest Venture Partners XII, LP ("NVP XII") to its limited and general partners.

F4 · ownership.nature: The securities shown on Line 2 of Table I represent securities held of record by NVP XII. By virtue of his position as an officer of NVP Associates, the managing member of the general partner of NVP XII, Casper de Clercq may be deemed to share voting and dispositive power with respect to such securities. Mr. de Clercq disclaims beneficial ownership of all such securities, except to the extent of any pecuniary interest therein.

SEC source: 0001209191-17-032087 · doc4.xml · nonDerivative · entry 1

de Clercq Casper L. · CIK 0001614601 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Limited Partnership

Disclosed balance after: 0

F1 · kind: Shares were disposed via pro rata in-kind distribution of Issuer's common stock from Norwest Venture Partners XI, LP ("NVP XI") to its limited and general partners.

F1 · price: Shares were disposed via pro rata in-kind distribution of Issuer's common stock from Norwest Venture Partners XI, LP ("NVP XI") to its limited and general partners.

F2 · ownership.nature: The securities shown on Line 1 of Table I represent securities held of record by NVP XI. By virtue of his position as an officer of NVP Associates, LLC ("NVP Associates"), the managing member of the general partner of NVP XI, Casper de Clercq may be deemed to share voting and dispositive power with respect to such securities. Mr. de Clercq disclaims beneficial ownership of all such securities, except to the extent of any pecuniary interest therein.

SEC source: 0001012975-17-000441 · edgar.xml · nonDerivative · entry 1

Lathi Vijay K · CIK 0001340806 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 1,541,589

F1 · ownership.nature: Represents shares directly beneficially owned by New Leaf Ventures II, L.P. ("NLV II"). The Reporting Person is an individual manager of New Leaf Venture Management II, L.L.C. ("Management II"). Management II is the general partner of New Leaf Venture Associates II, L.P. ("Associates II"). Associates II is the general partner of NLV II. As such, the Reporting Person shares voting and dispositive control with respect to the shares held by NLV II. The Reporting Person disclaims beneficial ownership of the shares held by NLV II, except to the extent of his proportionate pecuniary interest therein.

SEC source: 0001209191-17-031386 · doc4.xml · nonDerivative · entry 2

Norwest Venture Partners XI, LP · CIK 0001534522 · 10% owner

Crowe Jeffrey · CIK 0001535261 · 10% owner

Howard Matthew D. · CIK 0001576176 · 10% owner

Norwest Venture Partners XII, LP · CIK 0001614660 · 10% owner

HAQUE PROMOD · CIK 0001089744 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Limited Partnership

Disclosed balance after: 284,747

F3 · kind: Shares were disposed via a pro rata in-kind distribution of Issuer's common stock from Norwest Venture Partners XII, LP ("NVP XII") to its limited and general partners.

F3 · price: Shares were disposed via a pro rata in-kind distribution of Issuer's common stock from Norwest Venture Partners XII, LP ("NVP XII") to its limited and general partners.

F4 · ownership.nature: The securities shown on Line 2 of Table I represent securities held of record by NVP XII. By virtue of their positions as co-Chief Executive Officers of NVP Associates, the managing member of the general partner of NVP XII, Promod Haque, Jeffrey Crowe and Matthew D. Howard may be deemed to share voting and dispositive power with respect to such securities. Messers. Haque, Crowe and Howard disclaim beneficial ownership of all such securities, except to the extent of any pecuniary interest therein.

SEC source: 0001209191-17-031386 · doc4.xml · nonDerivative · entry 1

Norwest Venture Partners XI, LP · CIK 0001534522 · 10% owner

Crowe Jeffrey · CIK 0001535261 · 10% owner

Howard Matthew D. · CIK 0001576176 · 10% owner

Norwest Venture Partners XII, LP · CIK 0001614660 · 10% owner

HAQUE PROMOD · CIK 0001089744 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 284,747

F1 · security: The securities shown on Line 1 of Table I represent securities held of record by Norwest Venture Partners XI, LP ("NVP XI"). By virtue of their positions as co-Chief Executive Officers of NVP Associates, LLC ("NVP Associates"), the managing member of the general partner of NVP XI, Promod Haque, Jeffrey Crowe and Matthew D. Howard may be deemed to share voting and dispositive power with respect to such securities. Messrs. Haque, Crowe and Howard disclaim beneficial ownership of all such securities, except to the extent of any pecuniary interest therein.

F2 · kind: Shares were disposed via a pro rata in-kind distribution of Issuer's common stock from NVP XI to its limited and general partners.

F2 · price: Shares were disposed via a pro rata in-kind distribution of Issuer's common stock from NVP XI to its limited and general partners.

SEC source: 0001209191-17-031385 · doc4.xml · nonDerivative · entry 2

de Clercq Casper L. · CIK 0001614601 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Limited Partnership

Disclosed balance after: 284,747

F3 · kind: Shares were disposed via pro rata in-kind distribution of Issuer's common stock from Norwest Venture Partners XII, LP ("NVP XII") to its limited and general partners.

F3 · price: Shares were disposed via pro rata in-kind distribution of Issuer's common stock from Norwest Venture Partners XII, LP ("NVP XII") to its limited and general partners.

F4 · ownership.nature: The securities shown on Line 2 of Table I represent securities held of record by NVP XII. By virtue of his position as an officer of NVP Associates, the managing member of the general partner of NVP XII, Casper de Clercq may be deemed to share voting and dispositive power with respect to such securities. Mr. de Clercq disclaims beneficial ownership of all such securities, except to the extent of any pecuniary interest therein.

SEC source: 0001209191-17-031385 · doc4.xml · nonDerivative · entry 1

de Clercq Casper L. · CIK 0001614601 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Limited Partnership

Disclosed balance after: 284,747

F1 · kind: Shares were disposed via pro rata in-kind distribution of Issuer's common stock from Norwest Venture Partners XI, LP ("NVP XI") to its limited and general partners.

F1 · price: Shares were disposed via pro rata in-kind distribution of Issuer's common stock from Norwest Venture Partners XI, LP ("NVP XI") to its limited and general partners.

F2 · ownership.nature: The securities shown on Line 1 of Table I represent securities held of record by NVP XI. By virtue of his position as an officer of NVP Associates, LLC ("NVP Associates"), the managing member of the general partner of NVP XI, Casper de Clercq may be deemed to share voting and dispositive power with respect to such securities. Mr. de Clercq disclaims beneficial ownership of all such securities, except to the extent of any pecuniary interest therein.

SEC source: 0000899243-17-018094 · doc4.xml · derivative · entry 3

Lathi Vijay K · CIK 0001340806 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 3,007

Underlying: Common Stock · 3,007 shares

Expires 2027-04-26

F3 · derivative.exercise_date: The option vests in twelve equal monthly installments beginning on May 26, 2017.

SEC source: 0000899243-17-018094 · doc4.xml · nonDerivative · entry 1

Lathi Vijay K · CIK 0001340806 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,405

F1 · shares: The reported securities are represented by restricted stock units ("RSUs"), which represents a contingent right to receive shares of IRTC common stock. The RSUs fully vest on April 26, 2018.

SEC source: 0000899243-17-018059 · doc4.xml · derivative · entry 2

RUBASH MARK J · CIK 0001209186 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,653

Underlying: Common Stock · 2,653 shares

Expires 2027-03-27

F2 · derivative.exercise_date: The option vests in twelve equal monthly installments beginning on April 27, 2017.

SEC source: 0000899243-17-018059 · doc4.xml · nonDerivative · entry 1

RUBASH MARK J · CIK 0001209186 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,361

F1 · shares: The reported securities are represented by restricted stock units ("RSUs"), which represents a contingent right to receive shares of IRTC common stock. The RSUs fully vest on March 27, 2018.

SEC source: 0000899243-17-004548 · doc4.xml · derivative · entry 2

Garrett Matthew C. · CIK 0001668499 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,900

Underlying: Common Stock · 24,900 shares

Expires 2027-02-16

F1 · derivative.exercise_date: The option vests and the shares become exercisable according to the following schedule: 1/4 on March 1, 2018 and 1/36 of the remaining shares on each full calendar month thereafter.

SEC source: 0000899243-17-004548 · doc4.xml · nonDerivative · entry 1

Garrett Matthew C. · CIK 0001668499 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,000

F2 · shares: The reported securities are represented by restricted stock units ("RSUs"), which represents a contingent right to receive one share of IRTC common stock. The RSUs vest in four equal annual installments beginning on March 1, 2018

SEC source: 0000899243-17-004551 · doc4.xml · derivative · entry 2

Vort David A · CIK 0001670676 · EVP, Sales

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,400

Underlying: Common Stock · 25,400 shares

Expires 2027-02-16

F1 · derivative.exercise_date: The option vests and the shares become exercisable according to the following schedule: 1/4 on March 1, 2018 and 1/36 of the remaining shares on each full calendar month thereafter.

SEC source: 0000899243-17-004551 · doc4.xml · nonDerivative · entry 1

Vort David A · CIK 0001670676 · EVP, Sales

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,300

F2 · shares: The reported securities are represented by restricted stock units ("RSUs"), which represents a contingent right to receive one share of IRTC common stock. The RSUs vest in four equal annual installments beginning on March 1, 2018.

SEC source: 0000899243-17-004550 · doc4.xml · derivative · entry 2

Sung Derrick · CIK 0001670118 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,000

Underlying: Common Stock · 14,000 shares

Expires 2027-02-16

F1 · derivative.exercise_date: The option vests and the shares become exercisable according to the following schedule: 1/4 on March 1, 2018 and 1/36 of the remaining shares on each full calendar month thereafter.

SEC source: 0000899243-17-004550 · doc4.xml · nonDerivative · entry 1

Sung Derrick · CIK 0001670118 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,900

F2 · shares: The reported securities are represented by restricted stock units ("RSUs"), which represents a contingent right to receive one share of IRTC common stock. The RSUs vest in four equal annual installments beginning on March 1, 2018.

SEC source: 0000899243-17-004549 · doc4.xml · derivative · entry 2

King Kevin M · CIK 0001385014 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2027-02-16

F1 · derivative.exercise_date: The option vests and the shares become exercisable according to the following schedule: 1/4 on March 1, 2018 and 1/36 of the remaining shares on each full calendar month thereafter.

SEC source: 0000899243-17-004549 · doc4.xml · nonDerivative · entry 1

King Kevin M · CIK 0001385014 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,000

F2 · shares: The reported securities are represented by restricted stock units ("RSUs"), which represents a contingent right to receive one share of IRTC common stock. The RSUs vest in four equal annual installments beginning on March 1, 2018.

SEC source: 0000899243-17-019830 · doc4.xml · derivative · entry 1

Scott Raymond W. · CIK 0001669477 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,877

Underlying: Common Stock · 6,877 shares

Expires 2026-12-12

F1 · derivative.exercise_date: The option vests in twelve equal monthly installments beginning on January 12, 2017.

SEC source: 0001209191-16-146911 · doc4.xml · derivative · entry 6

Norwest Venture Partners XI, LP · CIK 0001534522 · 10% owner

Crowe Jeffrey · CIK 0001535261 · 10% owner

Howard Matthew D. · CIK 0001576176 · 10% owner

Norwest Venture Partners XII, LP · CIK 0001614660 · 10% owner

HAQUE PROMOD · CIK 0001089744 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Limited Partnership

Disclosed balance after: 0

Underlying: Common Stock · 397,883 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · derivative.exercise_price: The Series E Convertible Preferred Stock automatically converted into common stock on a one for one basis immediately prior to the completion of the Issuer's initial public offering of common stock and has no expiration date.

F5 · derivative.exercise_date: The Series E Convertible Preferred Stock automatically converted into common stock on a one for one basis immediately prior to the completion of the Issuer's initial public offering of common stock and has no expiration date.

F5 · derivative.expiration_date: The Series E Convertible Preferred Stock automatically converted into common stock on a one for one basis immediately prior to the completion of the Issuer's initial public offering of common stock and has no expiration date.

F6 · ownership.nature: The securities shown on Line 2 of Table I and Lines 3 and 4 of Table II represent securities held of record by Norwest Venture Partners XII, LP ("NVP XII"). By virtue of their positions as co-Chief Executive Officers of NVP Associates, LLC("NVP Associates"), the managing member of the general partner of NVP XII, Promod Haque, Jeffrey Crowe and Matthew D. Howard may be deemed to share voting and dispositive power with respect to such securities. Messers. Haque, Crowe and Howard disclaim beneficial ownership of all such securities, except to the extent of any pecuniary interest therein.

SEC source: 0001209191-16-146911 · doc4.xml · derivative · entry 5

Norwest Venture Partners XI, LP · CIK 0001534522 · 10% owner

Crowe Jeffrey · CIK 0001535261 · 10% owner

Howard Matthew D. · CIK 0001576176 · 10% owner

Norwest Venture Partners XII, LP · CIK 0001614660 · 10% owner

HAQUE PROMOD · CIK 0001089744 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Limited Partnership

Disclosed balance after: 0

Underlying: Common Stock · 786,864 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_price: The Series D Convertible Preferred Stock automatically converted into common stock on a one for one basis immediately prior to the completion of the Issuer's initial public offering of common stock and has no expiration date.

F4 · derivative.exercise_date: The Series D Convertible Preferred Stock automatically converted into common stock on a one for one basis immediately prior to the completion of the Issuer's initial public offering of common stock and has no expiration date.

F4 · derivative.expiration_date: The Series D Convertible Preferred Stock automatically converted into common stock on a one for one basis immediately prior to the completion of the Issuer's initial public offering of common stock and has no expiration date.

F6 · ownership.nature: The securities shown on Line 2 of Table I and Lines 3 and 4 of Table II represent securities held of record by Norwest Venture Partners XII, LP ("NVP XII"). By virtue of their positions as co-Chief Executive Officers of NVP Associates, LLC("NVP Associates"), the managing member of the general partner of NVP XII, Promod Haque, Jeffrey Crowe and Matthew D. Howard may be deemed to share voting and dispositive power with respect to such securities. Messers. Haque, Crowe and Howard disclaim beneficial ownership of all such securities, except to the extent of any pecuniary interest therein.

SEC source: 0001209191-16-146911 · doc4.xml · derivative · entry 4

Norwest Venture Partners XI, LP · CIK 0001534522 · 10% owner

Crowe Jeffrey · CIK 0001535261 · 10% owner

Howard Matthew D. · CIK 0001576176 · 10% owner

Norwest Venture Partners XII, LP · CIK 0001614660 · 10% owner

HAQUE PROMOD · CIK 0001089744 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 397,883 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The securities shown on Line 1 of Table I and Lines 1 and 2 of Table II represent securities held of record by Norwest Venture Partners XI, LP ("NVP XI"). By virtue of their positions as co-Chief Executive Officers of NVP Associates, LLC("NVP Associates"), the managing member of the general partner of NVP XI, Promod Haque, Jeffrey Crowe and Matthew D. Howard may be deemed to share voting and dispositive power with respect to such securities. Messrs. Haque, Crowe and Howard disclaim beneficial ownership of all such securities, except to the extent of any pecuniary interest therein.

F3 · derivative.exercise_price: The Series E Convertible Preferred Stock automatically converted into common stock on a one for one basis immediately prior to the completion of the Issuer's initial public offering of common stock and has no expiration date.

F3 · derivative.exercise_date: The Series E Convertible Preferred Stock automatically converted into common stock on a one for one basis immediately prior to the completion of the Issuer's initial public offering of common stock and has no expiration date.

F3 · derivative.expiration_date: The Series E Convertible Preferred Stock automatically converted into common stock on a one for one basis immediately prior to the completion of the Issuer's initial public offering of common stock and has no expiration date.

SEC source: 0001209191-16-146911 · doc4.xml · derivative · entry 3

Norwest Venture Partners XI, LP · CIK 0001534522 · 10% owner

Crowe Jeffrey · CIK 0001535261 · 10% owner

Howard Matthew D. · CIK 0001576176 · 10% owner

Norwest Venture Partners XII, LP · CIK 0001614660 · 10% owner

HAQUE PROMOD · CIK 0001089744 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 786,864 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The securities shown on Line 1 of Table I and Lines 1 and 2 of Table II represent securities held of record by Norwest Venture Partners XI, LP ("NVP XI"). By virtue of their positions as co-Chief Executive Officers of NVP Associates, LLC("NVP Associates"), the managing member of the general partner of NVP XI, Promod Haque, Jeffrey Crowe and Matthew D. Howard may be deemed to share voting and dispositive power with respect to such securities. Messrs. Haque, Crowe and Howard disclaim beneficial ownership of all such securities, except to the extent of any pecuniary interest therein.

F2 · derivative.exercise_price: The Series D Convertible Preferred Stock automatically converted into common stock on a one for one basis immediately prior to the completion of the Issuer's initial public offering of common stock and has no expiration date.

F2 · derivative.exercise_date: The Series D Convertible Preferred Stock automatically converted into common stock on a one for one basis immediately prior to the completion of the Issuer's initial public offering of common stock and has no expiration date.

F2 · derivative.expiration_date: The Series D Convertible Preferred Stock automatically converted into common stock on a one for one basis immediately prior to the completion of the Issuer's initial public offering of common stock and has no expiration date.

SEC source: 0001209191-16-146911 · doc4.xml · nonDerivative · entry 2

Norwest Venture Partners XI, LP · CIK 0001534522 · 10% owner

Crowe Jeffrey · CIK 0001535261 · 10% owner

Howard Matthew D. · CIK 0001576176 · 10% owner

Norwest Venture Partners XII, LP · CIK 0001614660 · 10% owner

HAQUE PROMOD · CIK 0001089744 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · By Limited Partnership

Disclosed balance after: 1,184,747

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · price: The Series D Convertible Preferred Stock automatically converted into common stock on a one for one basis immediately prior to the completion of the Issuer's initial public offering of common stock and has no expiration date.

F5 · price: The Series E Convertible Preferred Stock automatically converted into common stock on a one for one basis immediately prior to the completion of the Issuer's initial public offering of common stock and has no expiration date.

F6 · ownership.nature: The securities shown on Line 2 of Table I and Lines 3 and 4 of Table II represent securities held of record by Norwest Venture Partners XII, LP ("NVP XII"). By virtue of their positions as co-Chief Executive Officers of NVP Associates, LLC("NVP Associates"), the managing member of the general partner of NVP XII, Promod Haque, Jeffrey Crowe and Matthew D. Howard may be deemed to share voting and dispositive power with respect to such securities. Messers. Haque, Crowe and Howard disclaim beneficial ownership of all such securities, except to the extent of any pecuniary interest therein.

SEC source: 0001209191-16-146911 · doc4.xml · nonDerivative · entry 1

Norwest Venture Partners XI, LP · CIK 0001534522 · 10% owner

Crowe Jeffrey · CIK 0001535261 · 10% owner

Howard Matthew D. · CIK 0001576176 · 10% owner

Norwest Venture Partners XII, LP · CIK 0001614660 · 10% owner

HAQUE PROMOD · CIK 0001089744 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,184,747

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · security: The securities shown on Line 1 of Table I and Lines 1 and 2 of Table II represent securities held of record by Norwest Venture Partners XI, LP ("NVP XI"). By virtue of their positions as co-Chief Executive Officers of NVP Associates, LLC("NVP Associates"), the managing member of the general partner of NVP XI, Promod Haque, Jeffrey Crowe and Matthew D. Howard may be deemed to share voting and dispositive power with respect to such securities. Messrs. Haque, Crowe and Howard disclaim beneficial ownership of all such securities, except to the extent of any pecuniary interest therein.

F2 · price: The Series D Convertible Preferred Stock automatically converted into common stock on a one for one basis immediately prior to the completion of the Issuer's initial public offering of common stock and has no expiration date.

F3 · price: The Series E Convertible Preferred Stock automatically converted into common stock on a one for one basis immediately prior to the completion of the Issuer's initial public offering of common stock and has no expiration date.

SEC source: 0000899243-16-032254 · doc4.xml · derivative · entry 2

Scott Raymond W. · CIK 0001669477 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 34,205 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: The Series E Convertible Preferred Stock converted into Common Stock on a 1-for-1 basis and had no expiration date.

F1 · derivative.exercise_date: The Series E Convertible Preferred Stock converted into Common Stock on a 1-for-1 basis and had no expiration date.

F1 · derivative.expiration_date: The Series E Convertible Preferred Stock converted into Common Stock on a 1-for-1 basis and had no expiration date.

F2 · derivative.underlying_shares: Reflects 5.882698 for 1 reverse stock split which became effective on October 5, 2016.

SEC source: 0000899243-16-032254 · doc4.xml · nonDerivative · entry 1

Scott Raymond W. · CIK 0001669477 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,903

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: The Series E Convertible Preferred Stock converted into Common Stock on a 1-for-1 basis and had no expiration date.

F2 · balance_after: Reflects 5.882698 for 1 reverse stock split which became effective on October 5, 2016.

SEC source: 0000899243-16-032257 · doc4.xml · derivative · entry 6

New Leaf Ventures II, L.P. · CIK 0001441439 · 10% owner

Delagardelle Jeani · CIK 0001441563 · 10% owner

HUNT RONALD · CIK 0001247851 · 10% owner

Ratcliffe Liam · CIK 0001547100 · 10% owner

New Leaf Venture Associates II, L.P. · CIK 0001441858 · 10% owner

New Leaf Venture Management II, L.L.C. · CIK 0001441857 · 10% owner

Chambon Philippe O. · CIK 0001192212 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 72,389 shares

Expires 2019-11-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.underlying_shares: Reflects 5.882698 for 1 reverse stock split which became effective on October 5, 2016.

F5 · ownership.direct: Represents shares directly beneficially owned by New Leaf Ventures II, L.P. ("NLV II"). New Leaf Venture Associates II, L.P. ("NLV Associates II") is the general partner of NLV II and New Leaf Venture Management II, L.L.C. ("NLV Management II") is the general partner of NLV Associates II. Philippe O. Chambon, Jeani Delagardelle, Ronald Hunt, Vijay Lathi and Liam Ratcliffe are the individual managers of NLV Management II (the "Individual Managers"). NLV Associates II and NLV Management II disclaim beneficial ownership of such shares, except to the extent of their pecuniary interest therein. Vijay Lathi is a director of the Issuer and, accordingly, files separate Section 16 reports. As one of five individual managers, each of the Individual Managers disclaims beneficial ownership over the shares reported herein, and in all events disclaims pecuniary interest except to the extent of his or her economic interest.

SEC source: 0000899243-16-032257 · doc4.xml · derivative · entry 5

New Leaf Ventures II, L.P. · CIK 0001441439 · 10% owner

Delagardelle Jeani · CIK 0001441563 · 10% owner

HUNT RONALD · CIK 0001247851 · 10% owner

Ratcliffe Liam · CIK 0001547100 · 10% owner

New Leaf Venture Associates II, L.P. · CIK 0001441858 · 10% owner

New Leaf Venture Management II, L.L.C. · CIK 0001441857 · 10% owner

Chambon Philippe O. · CIK 0001192212 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 155,548 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: The Series E Convertible Preferred Stock converted into Common Stock on a 1-for-1 basis and had no expiration date.

F3 · derivative.exercise_date: The Series E Convertible Preferred Stock converted into Common Stock on a 1-for-1 basis and had no expiration date.

F3 · derivative.expiration_date: The Series E Convertible Preferred Stock converted into Common Stock on a 1-for-1 basis and had no expiration date.

F4 · derivative.underlying_shares: Reflects 5.882698 for 1 reverse stock split which became effective on October 5, 2016.

F5 · ownership.direct: Represents shares directly beneficially owned by New Leaf Ventures II, L.P. ("NLV II"). New Leaf Venture Associates II, L.P. ("NLV Associates II") is the general partner of NLV II and New Leaf Venture Management II, L.L.C. ("NLV Management II") is the general partner of NLV Associates II. Philippe O. Chambon, Jeani Delagardelle, Ronald Hunt, Vijay Lathi and Liam Ratcliffe are the individual managers of NLV Management II (the "Individual Managers"). NLV Associates II and NLV Management II disclaim beneficial ownership of such shares, except to the extent of their pecuniary interest therein. Vijay Lathi is a director of the Issuer and, accordingly, files separate Section 16 reports. As one of five individual managers, each of the Individual Managers disclaims beneficial ownership over the shares reported herein, and in all events disclaims pecuniary interest except to the extent of his or her economic interest.

SEC source: 0000899243-16-032257 · doc4.xml · derivative · entry 4

New Leaf Ventures II, L.P. · CIK 0001441439 · 10% owner

Delagardelle Jeani · CIK 0001441563 · 10% owner

HUNT RONALD · CIK 0001247851 · 10% owner

Ratcliffe Liam · CIK 0001547100 · 10% owner

New Leaf Venture Associates II, L.P. · CIK 0001441858 · 10% owner

New Leaf Venture Management II, L.L.C. · CIK 0001441857 · 10% owner

Chambon Philippe O. · CIK 0001192212 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 190,154 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: The Series D Convertible Preferred Stock converted into Common Stock on a 1-for-1 basis and had no expiration date.

F2 · derivative.exercise_date: The Series D Convertible Preferred Stock converted into Common Stock on a 1-for-1 basis and had no expiration date.

F2 · derivative.expiration_date: The Series D Convertible Preferred Stock converted into Common Stock on a 1-for-1 basis and had no expiration date.

F4 · derivative.underlying_shares: Reflects 5.882698 for 1 reverse stock split which became effective on October 5, 2016.

F5 · ownership.direct: Represents shares directly beneficially owned by New Leaf Ventures II, L.P. ("NLV II"). New Leaf Venture Associates II, L.P. ("NLV Associates II") is the general partner of NLV II and New Leaf Venture Management II, L.L.C. ("NLV Management II") is the general partner of NLV Associates II. Philippe O. Chambon, Jeani Delagardelle, Ronald Hunt, Vijay Lathi and Liam Ratcliffe are the individual managers of NLV Management II (the "Individual Managers"). NLV Associates II and NLV Management II disclaim beneficial ownership of such shares, except to the extent of their pecuniary interest therein. Vijay Lathi is a director of the Issuer and, accordingly, files separate Section 16 reports. As one of five individual managers, each of the Individual Managers disclaims beneficial ownership over the shares reported herein, and in all events disclaims pecuniary interest except to the extent of his or her economic interest.

SEC source: 0000899243-16-032257 · doc4.xml · derivative · entry 3

New Leaf Ventures II, L.P. · CIK 0001441439 · 10% owner

Delagardelle Jeani · CIK 0001441563 · 10% owner

HUNT RONALD · CIK 0001247851 · 10% owner

Ratcliffe Liam · CIK 0001547100 · 10% owner

New Leaf Venture Associates II, L.P. · CIK 0001441858 · 10% owner

New Leaf Venture Management II, L.L.C. · CIK 0001441857 · 10% owner

Chambon Philippe O. · CIK 0001192212 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 1,370,887 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: The Series C Convertible Preferred Stock converted into Common Stock on a 2.24685484-for-1 basis and had no expiration date.

F1 · derivative.exercise_date: The Series C Convertible Preferred Stock converted into Common Stock on a 2.24685484-for-1 basis and had no expiration date.

F1 · derivative.expiration_date: The Series C Convertible Preferred Stock converted into Common Stock on a 2.24685484-for-1 basis and had no expiration date.

F4 · derivative.underlying_shares: Reflects 5.882698 for 1 reverse stock split which became effective on October 5, 2016.

F5 · ownership.direct: Represents shares directly beneficially owned by New Leaf Ventures II, L.P. ("NLV II"). New Leaf Venture Associates II, L.P. ("NLV Associates II") is the general partner of NLV II and New Leaf Venture Management II, L.L.C. ("NLV Management II") is the general partner of NLV Associates II. Philippe O. Chambon, Jeani Delagardelle, Ronald Hunt, Vijay Lathi and Liam Ratcliffe are the individual managers of NLV Management II (the "Individual Managers"). NLV Associates II and NLV Management II disclaim beneficial ownership of such shares, except to the extent of their pecuniary interest therein. Vijay Lathi is a director of the Issuer and, accordingly, files separate Section 16 reports. As one of five individual managers, each of the Individual Managers disclaims beneficial ownership over the shares reported herein, and in all events disclaims pecuniary interest except to the extent of his or her economic interest.

SEC source: 0000899243-16-032257 · doc4.xml · nonDerivative · entry 2

New Leaf Ventures II, L.P. · CIK 0001441439 · 10% owner

Delagardelle Jeani · CIK 0001441563 · 10% owner

HUNT RONALD · CIK 0001247851 · 10% owner

Ratcliffe Liam · CIK 0001547100 · 10% owner

New Leaf Venture Associates II, L.P. · CIK 0001441858 · 10% owner

New Leaf Venture Management II, L.L.C. · CIK 0001441857 · 10% owner

Chambon Philippe O. · CIK 0001192212 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,741,589

F4 · balance_after: Reflects 5.882698 for 1 reverse stock split which became effective on October 5, 2016.

F5 · ownership.direct: Represents shares directly beneficially owned by New Leaf Ventures II, L.P. ("NLV II"). New Leaf Venture Associates II, L.P. ("NLV Associates II") is the general partner of NLV II and New Leaf Venture Management II, L.L.C. ("NLV Management II") is the general partner of NLV Associates II. Philippe O. Chambon, Jeani Delagardelle, Ronald Hunt, Vijay Lathi and Liam Ratcliffe are the individual managers of NLV Management II (the "Individual Managers"). NLV Associates II and NLV Management II disclaim beneficial ownership of such shares, except to the extent of their pecuniary interest therein. Vijay Lathi is a director of the Issuer and, accordingly, files separate Section 16 reports. As one of five individual managers, each of the Individual Managers disclaims beneficial ownership over the shares reported herein, and in all events disclaims pecuniary interest except to the extent of his or her economic interest.

SEC source: 0000899243-16-032257 · doc4.xml · nonDerivative · entry 1

New Leaf Ventures II, L.P. · CIK 0001441439 · 10% owner

Delagardelle Jeani · CIK 0001441563 · 10% owner

HUNT RONALD · CIK 0001247851 · 10% owner

Ratcliffe Liam · CIK 0001547100 · 10% owner

New Leaf Venture Associates II, L.P. · CIK 0001441858 · 10% owner

New Leaf Venture Management II, L.L.C. · CIK 0001441857 · 10% owner

Chambon Philippe O. · CIK 0001192212 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,716,589

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: The Series C Convertible Preferred Stock converted into Common Stock on a 2.24685484-for-1 basis and had no expiration date.

F2 · price: The Series D Convertible Preferred Stock converted into Common Stock on a 1-for-1 basis and had no expiration date.

F3 · price: The Series E Convertible Preferred Stock converted into Common Stock on a 1-for-1 basis and had no expiration date.

F4 · balance_after: Reflects 5.882698 for 1 reverse stock split which became effective on October 5, 2016.

F5 · ownership.direct: Represents shares directly beneficially owned by New Leaf Ventures II, L.P. ("NLV II"). New Leaf Venture Associates II, L.P. ("NLV Associates II") is the general partner of NLV II and New Leaf Venture Management II, L.L.C. ("NLV Management II") is the general partner of NLV Associates II. Philippe O. Chambon, Jeani Delagardelle, Ronald Hunt, Vijay Lathi and Liam Ratcliffe are the individual managers of NLV Management II (the "Individual Managers"). NLV Associates II and NLV Management II disclaim beneficial ownership of such shares, except to the extent of their pecuniary interest therein. Vijay Lathi is a director of the Issuer and, accordingly, files separate Section 16 reports. As one of five individual managers, each of the Individual Managers disclaims beneficial ownership over the shares reported herein, and in all events disclaims pecuniary interest except to the extent of his or her economic interest.

SEC source: 0000899243-16-032255 · doc4.xml · derivative · entry 6

Lathi Vijay K · CIK 0001340806 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See Footnote

Disclosed balance after: 0

Underlying: Common Stock · 72,389 shares

Expires 2019-11-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.underlying_shares: Reflects 5.882698 for 1 reverse stock split which became effective on October 5, 2016.

F5 · ownership.nature: Represents shares directly beneficially owned by New Leaf Ventures II, L.P. ("NLV II"). The Reporting Person is an individual manager of New Leaf Venture Management II, L.L.C. ("Management II"). Management II is the general partner of New Leaf Venture Associates II, L.P. ("Associates II"). Associates II is the general partner of New Leaf Ventures II, L.P. ("NLV II"). As such, the Reporting Person shares voting and dispositive control with respect to the shares held by NLV II. The Reporting Person disclaims beneficial ownership of the shares held by NLV II, except to the extent of his proportionate pecuniary interest therein.