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Nasdaq · USD

IONS

IONIS PHARMACEUTICALS INC

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1182
SEC CIK
0000874015
Parsed reports
834

Last 12 months

Inside the activity.

2 purchase rows · 116 sale rows

Disclosed non-derivative P/S rows, by transaction month. Includes amendments and private transactions.
Monthly counts
MonthPurchasesSales
Nov 2025015
Dec 202502
Jan 2026029
Feb 202607
Mar 2026031
Apr 202609
May 202606
Jun 2026011
Jul 202626
Aug 202600
Sep 202600
Oct 202600

Latest available

Insider transactions

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Purchases/sales include open-market and private transactions. Plan disclosure applies to the filing; individual rows may differ. “Not disclosed” is not “unplanned.”

The cutoff filters transaction history only. Company summaries and owner relationships show the latest available disclosures. Parser corrections can improve historical records.

Transaction dateOwner / reported roleActivity / securityShares / unitsReported priceReported valueDetails
January 15, 2019 Filed Jan 18, 2019 00:19 UTC Exercise / conversionRestricted Stock Units · Derivative 20,656 $0.00 $0.00
Disclosure

SEC source: 0000874015-19-000016 · edgar.xml · derivative · entry 3

PARSHALL B LYNNE · CIK 0001073385 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,100

Underlying: Common Stock · 20,656 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F4 · derivative.exercise_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

F4 · derivative.expiration_date: Restricted Stock Units vest in four equal annual installments. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company.

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January 15, 2019 Filed Jan 18, 2019 00:19 UTC Tax withholdingCommon Stock 6,159 $58.26 $358,823.34
Disclosure

SEC source: 0000874015-19-000016 · edgar.xml · nonDerivative · entry 2

PARSHALL B LYNNE · CIK 0001073385 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,677

F2 · kind: Shares withheld to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice.

F2 · shares: Shares withheld to cover the required tax withholding obligations pursuant to the 2011 Equity Incentive Plan Restricted Stock Unit Agreement and Grant Notice.

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January 15, 2019 Filed Jan 18, 2019 00:19 UTC Exercise / conversionCommon Stock 20,656 $0.00 $0.00
Disclosure

SEC source: 0000874015-19-000016 · edgar.xml · nonDerivative · entry 1

PARSHALL B LYNNE · CIK 0001073385 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 58,836

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

F1 · shares: Acquired pursuant to vesting and release of shares pursuant to Restricted Stock Unit awards.

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January 03, 2019 Filed Jan 4, 2019 00:50 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
Exercise / conversionEmployee Stock Option (right to buy) · Derivative 4,000 $0.00 Strike: $39.87 $0.00
Disclosure

SEC source: 0000874015-19-000014 · edgar.xml · derivative · entry 8

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,875

Underlying: Common Stock · 4,000 shares

Expires 2021-01-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 03, 2019 Filed Jan 4, 2019 00:50 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
Exercise / conversionEmpoyee Stock Option (right to buy) · Derivative 400 $0.00 Strike: $10.82 $0.00
Disclosure

SEC source: 0000874015-19-000014 · edgar.xml · derivative · entry 7

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 400 shares

Expires 2020-01-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
January 03, 2019 Filed Jan 4, 2019 00:50 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
SaleCommon Stock 4,000 $54.80 $219,200.00
Disclosure

SEC source: 0000874015-19-000014 · edgar.xml · nonDerivative · entry 5

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,584

F3 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 08/29/18.

F3 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 08/29/18.

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January 03, 2019 Filed Jan 4, 2019 00:50 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
Exercise / conversionCommon Stock 4,000 $39.87 $159,480.00
Disclosure

SEC source: 0000874015-19-000014 · edgar.xml · nonDerivative · entry 4

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,584

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 08/29/18.

F3 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 08/29/18.

Read SEC document
January 03, 2019 Filed Jan 4, 2019 00:50 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
SaleCommon Stock 400 $54.80 $21,920.00
Disclosure

SEC source: 0000874015-19-000014 · edgar.xml · nonDerivative · entry 3

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,584

F3 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 08/29/18.

F3 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 08/29/18.

Read SEC document
January 03, 2019 Filed Jan 4, 2019 00:50 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
Exercise / conversionCommon Stock 400 $10.82 $4,328.00
Disclosure

SEC source: 0000874015-19-000014 · edgar.xml · nonDerivative · entry 2

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,984

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 08/29/18.

F3 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 08/29/18.

Read SEC document
January 02, 2019 Filed Jan 4, 2019 00:44 UTC
HOUGEN ELIZABETH LSVP Finance & CFO
GrantEmployee Stock Option (right to buy) · Derivative 49,800 $0.00 Strike: $53.77 $0.00
Disclosure

SEC source: 0000874015-19-000010 · edgar.xml · derivative · entry 2

HOUGEN ELIZABETH L · CIK 0001074773 · SVP Finance & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 49,800

Underlying: Common Stock · 49,800 shares

Expires 2026-01-01

F2 · derivative.exercise_date: Grant of 01/02/2019 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan. 25% of the shares subject to the option vest and become exercisable on 01/02/2020. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments over the next 3 years. Following this transaction, the option was exercisable as to 0 on 01/02/2019.

Read SEC document
January 02, 2019 Filed Jan 4, 2019 00:50 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
GrantEmployee Stock Option (right to buy) · Derivative 49,800 $0.00 Strike: $53.77 $0.00
Disclosure

SEC source: 0000874015-19-000014 · edgar.xml · derivative · entry 6

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 49,800

Underlying: Common Stock · 49,800 shares

Expires 2026-01-01

F2 · derivative.exercise_date: Grant of 01/02/2019 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan. 25% of the shares subject to the option vest and become exercisable on 01/02/2020. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments over the next 3 years. Following this transaction, the option was exercisable as to 0 on 01/02/2019.

Read SEC document
January 02, 2019 Filed Jan 4, 2019 00:46 UTC
McDevitt DamienChief Business Officer
GrantEmployee Stock Option (right to buy) · Derivative 29,400 $0.00 Strike: $53.77 $0.00
Disclosure

SEC source: 0000874015-19-000012 · edgar.xml · derivative · entry 1

McDevitt Damien · CIK 0001742277 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,400

Underlying: Common Stock · 29,400 shares

Expires 2026-01-01

F1 · derivative.exercise_date: Grant of 01/02/2019 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan. 25% of the shares subject to the option vest and become exercisable on 01/02/2020. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments over the next 3 years. Following this transaction, the option was exercisable as to 0 on 01/02/2019.

Read SEC document
January 02, 2019 Filed Jan 4, 2019 00:42 UTC
Monia Brett PChief Operating Officer
GrantEmployee Stock Option (right to buy) · Derivative 102,900 $0.00 Strike: $53.77 $0.00
Disclosure

SEC source: 0000874015-19-000009 · edgar.xml · derivative · entry 3

Monia Brett P · CIK 0001537529 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 102,900

Underlying: Common Stock · 102,900 shares

Expires 2026-01-01

F2 · derivative.exercise_date: Grant of 01/02/2019 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan. 25% of the shares subject to the option vest and become exercisable on 01/02/2020. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments over the next 3 years. Following this transaction, the option was exercisable as to 0 on 01/02/2019.

Read SEC document
January 02, 2019 Filed Jan 4, 2019 00:42 UTC
Monia Brett PChief Operating Officer
SaleCommon Stock 214 $53.50 $11,449.00
Disclosure

SEC source: 0000874015-19-000009 · edgar.xml · nonDerivative · entry 2

Monia Brett P · CIK 0001537529 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,837

F3 · kind: The Sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 07/01/2014.

F3 · shares: The Sale reported in this Form 4 was effected pursuant to a Rule 10b5-1 Trading Plan adopted by the reporting person on 07/01/2014.

Read SEC document
January 02, 2019 Filed Jan 4, 2019 00:34 UTC
Geary Richard SSVP, Development
GrantEmployee Stock Option (right to buy) · Derivative 57,900 $0.00 Strike: $53.77 $0.00
Disclosure

SEC source: 0000874015-19-000006 · edgar.xml · derivative · entry 2

Geary Richard S · CIK 0001442730 · SVP, Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 57,900

Underlying: Common Stock · 57,900 shares

Expires 2026-01-01

F2 · derivative.exercise_date: Grant of 01/02/2019 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan. 25% of the shares subject to the option vest and become exercisable on 01/02/2020. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments over the next 3 years. Following this transaction, the option was exercisable as to 0 on 01/02/2019.

Read SEC document
January 02, 2019 Filed Jan 4, 2019 00:32 UTC
BENNETT C FRANKSVP, Antisense Research
GrantEmployee Stock Option (right to buy) · Derivative 46,800 $0.00 Strike: $53.77 $0.00
Disclosure

SEC source: 0000874015-19-000004 · edgar.xml · derivative · entry 2

BENNETT C FRANK · CIK 0001073387 · SVP, Antisense Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 46,800

Underlying: Common Stock · 46,800 shares

Expires 2026-01-01

F2 · derivative.exercise_date: Grant of 01/02/2019 to reporting person of stock options under the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan. 25% of the shares subject to the option vest and become exercisable on 01/02/2020. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments over the next 3 years. Following this transaction, the option was exercisable as to 0 on 01/02/2019.

Read SEC document
January 02, 2019 Filed Jan 4, 2019 00:29 UTC
CROOKE STANLEY TDirector · Chairman and CEO
GrantEmployee Stock Option (right to buy) · Derivative 12,000 $0.00 Strike: $53.77 $0.00
Disclosure

SEC source: 0000874015-19-000002 · edgar.xml · derivative · entry 2

CROOKE STANLEY T · CIK 0000897667 · Director · Chairman and CEO

10b5-1 filing: Not disclosed

Ownership: Indirect · By wife

Disclosed balance after: 12,000

Underlying: Common Stock · 12,000 shares

Expires 2026-01-01

F1 · derivative.exercise_date: Grant of 01/02/2019 to reporting person or reporting person's wife (as indicated) of stock options under the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan. 25% of the shares subject to the option vest and become exercisable on 01/02/2020. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments over the next 3 years. Following this transaction, the option was exercisable as to 0 on 01/02/2019.

Read SEC document
January 02, 2019 Filed Jan 4, 2019 00:29 UTC
CROOKE STANLEY TDirector · Chairman and CEO
GrantEmployee Stock Option (right to buy) · Derivative 143,400 $0.00 Strike: $53.77 $0.00
Disclosure

SEC source: 0000874015-19-000002 · edgar.xml · derivative · entry 1

CROOKE STANLEY T · CIK 0000897667 · Director · Chairman and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 143,400

Underlying: Common Stock · 143,400 shares

Expires 2026-01-01

F1 · derivative.exercise_date: Grant of 01/02/2019 to reporting person or reporting person's wife (as indicated) of stock options under the Ionis Pharmaceuticals, Inc. 2011 Equity Incentive Plan. 25% of the shares subject to the option vest and become exercisable on 01/02/2020. Thereafter, the remaining shares subject to the option vest and become exercisable in 36 equal monthly installments over the next 3 years. Following this transaction, the option was exercisable as to 0 on 01/02/2019.

Read SEC document
January 01, 2019 Filed Jan 4, 2019 00:44 UTC
HOUGEN ELIZABETH LSVP Finance & CFO
OtherCommon Stock 127 $36.45 $4,628.90
Disclosure

SEC source: 0000874015-19-000010 · edgar.xml · nonDerivative · entry 1

HOUGEN ELIZABETH L · CIK 0001074773 · SVP Finance & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,901

F1 · kind: Reporting shares acquired under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on January 1, 2019. These shares may not be sold until July 2, 2019.

F1 · shares: Reporting shares acquired under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on January 1, 2019. These shares may not be sold until July 2, 2019.

Read SEC document
January 01, 2019 Filed Jan 4, 2019 00:50 UTC
O'NEIL PATRICK R.SVP Legal & General Counsel
OtherCommon Stock 66 $36.45 $2,405.57
Disclosure

SEC source: 0000874015-19-000014 · edgar.xml · nonDerivative · entry 1

O'NEIL PATRICK R. · CIK 0001564926 · SVP Legal & General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,584

F1 · kind: Reporting shares acquired under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on January 1, 2019. These shares may not be sold until July 2, 2019.

F1 · shares: Reporting shares acquired under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on January 1, 2019. These shares may not be sold until July 2, 2019.

Read SEC document
January 01, 2019 Filed Jan 4, 2019 00:42 UTC
Monia Brett PChief Operating Officer
OtherCommon Stock 210 $36.45 $7,654.08
Disclosure

SEC source: 0000874015-19-000009 · edgar.xml · nonDerivative · entry 1

Monia Brett P · CIK 0001537529 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,051

F1 · kind: Reporting shares acquired under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on January 1, 2019. These shares may not be sold until July 2, 2019.

F1 · shares: Reporting shares acquired under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on January 1, 2019. These shares may not be sold until July 2, 2019.

Read SEC document
January 01, 2019 Filed Jan 4, 2019 00:34 UTC
Geary Richard SSVP, Development
OtherCommon Stock 407 $36.45 $14,834.34
Disclosure

SEC source: 0000874015-19-000006 · edgar.xml · nonDerivative · entry 1

Geary Richard S · CIK 0001442730 · SVP, Development

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,264

F1 · kind: Reporting shares acquired under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on January 1, 2019. These shares may not be sold until July 2, 2019.

F1 · shares: Reporting shares acquired under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on January 1, 2019. These shares may not be sold until July 2, 2019.

Read SEC document
January 01, 2019 Filed Jan 4, 2019 00:32 UTC
BENNETT C FRANKSVP, Antisense Research
OtherCommon Stock 128 $36.45 $4,665.34
Disclosure

SEC source: 0000874015-19-000004 · edgar.xml · nonDerivative · entry 1

BENNETT C FRANK · CIK 0001073387 · SVP, Antisense Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,524

F1 · kind: Reporting of shares acquired under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on January 1, 2019. These shares may not be sold until July 2, 2019.

F1 · shares: Reporting of shares acquired under the Ionis Pharmaceuticals, Inc. Amended and Restated 2000 Employee Stock Purchase Plan on January 1, 2019. These shares may not be sold until July 2, 2019.

Read SEC document
December 19, 2018 Filed Dec 20, 2018 22:55 UTC
HOUGEN ELIZABETH LSVP, Finance & CFO
Exercise / conversionEmployee Stock Option (right to buy) · Derivative 2,063 $0.00 Strike: $7.25 $0.00
Disclosure

SEC source: 0000874015-18-000132 · edgar.xml · derivative · entry 6

HOUGEN ELIZABETH L · CIK 0001074773 · SVP, Finance & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,063 shares

Expires 2019-01-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 19, 2018 Filed Dec 20, 2018 22:55 UTC
HOUGEN ELIZABETH LSVP, Finance & CFO
SaleCommon Stock 2,063 $52.05 $107,379.15
Disclosure

SEC source: 0000874015-18-000132 · edgar.xml · nonDerivative · entry 4

HOUGEN ELIZABETH L · CIK 0001074773 · SVP, Finance & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,774

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 11/07/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 11/07/2018.

Read SEC document
December 19, 2018 Filed Dec 20, 2018 22:55 UTC
HOUGEN ELIZABETH LSVP, Finance & CFO
Exercise / conversionCommon Stock 2,063 $7.25 $14,956.75
Disclosure

SEC source: 0000874015-18-000132 · edgar.xml · nonDerivative · entry 3

HOUGEN ELIZABETH L · CIK 0001074773 · SVP, Finance & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,837

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 11/07/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 11/07/2018.

Read SEC document
December 18, 2018 Filed Dec 20, 2018 22:55 UTC
HOUGEN ELIZABETH LSVP, Finance & CFO
Exercise / conversionEmployee Stock Option (right to buy) · Derivative 2,000 $0.00 Strike: $7.25 $0.00
Disclosure

SEC source: 0000874015-18-000132 · edgar.xml · derivative · entry 5

HOUGEN ELIZABETH L · CIK 0001074773 · SVP, Finance & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,063

Underlying: Common Stock · 2,000 shares

Expires 2019-01-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
December 18, 2018 Filed Dec 20, 2018 22:55 UTC
HOUGEN ELIZABETH LSVP, Finance & CFO
SaleCommon Stock 2,000 $52.00 $104,000.00
Disclosure

SEC source: 0000874015-18-000132 · edgar.xml · nonDerivative · entry 2

HOUGEN ELIZABETH L · CIK 0001074773 · SVP, Finance & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,774

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 11/07/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 11/07/2018.

Read SEC document
December 18, 2018 Filed Dec 20, 2018 22:55 UTC
HOUGEN ELIZABETH LSVP, Finance & CFO
Exercise / conversionCommon Stock 2,000 $7.25 $14,500.00
Disclosure

SEC source: 0000874015-18-000132 · edgar.xml · nonDerivative · entry 1

HOUGEN ELIZABETH L · CIK 0001074773 · SVP, Finance & CFO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,774

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 11/07/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 11/07/2018.

Read SEC document
November 23, 2018 Filed Nov 27, 2018 01:01 UTC
Monia Brett PChief Operating Officer
Exercise / conversionEmployee Stock Option (right to buy) · Derivative 34,000 $0.00 Strike: $14.69 $0.00
Disclosure

SEC source: 0000874015-18-000130 · edgar.xml · derivative · entry 3

Monia Brett P · CIK 0001537529 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 34,000 shares

Expires 2020-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 23, 2018 Filed Nov 27, 2018 01:01 UTC
Monia Brett PChief Operating Officer
SaleCommon Stock 34,000 $55.00 $1,870,057.80
Disclosure

SEC source: 0000874015-18-000130 · edgar.xml · nonDerivative · entry 2

Monia Brett P · CIK 0001537529 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,841

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 05/11/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 05/11/2018.

F2 · price: The price reported in Column 4 is a weighted average price. These share were sold in multiple transactions at prices ranging from $55.00 to $55.08, inclusiveThe reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4.

Read SEC document
November 23, 2018 Filed Nov 27, 2018 01:01 UTC
Monia Brett PChief Operating Officer
Exercise / conversionCommon Stock 34,000 $14.69 $499,460.00
Disclosure

SEC source: 0000874015-18-000130 · edgar.xml · nonDerivative · entry 1

Monia Brett P · CIK 0001537529 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 49,841

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 05/11/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 05/11/2018.

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November 01, 2018 Filed Nov 1, 2018 23:34 UTC
BENNETT C FRANKSVP, Antisense Research
Exercise / conversionEmployee Stock Option (right to buy) · Derivative 12,500 $0.00 Strike: $14.69 $0.00
Disclosure

SEC source: 0000874015-18-000124 · edgar.xml · derivative · entry 3

BENNETT C FRANK · CIK 0001073387 · SVP, Antisense Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,013

Underlying: Common Stock · 12,500 shares

Expires 2020-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
November 01, 2018 Filed Nov 1, 2018 23:34 UTC
BENNETT C FRANKSVP, Antisense Research
SaleCommon Stock 12,500 $49.54 $619,245.00
Disclosure

SEC source: 0000874015-18-000124 · edgar.xml · nonDerivative · entry 2

BENNETT C FRANK · CIK 0001073387 · SVP, Antisense Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,396

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 12/8/2017.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 12/8/2017.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $49.35 to $49.75, inclusive. The reporting person undertakes to provide to Ionis Pharmaceuticals, Inc., any security holder of Ionis Pharmaceuticals, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote (2) on this Form 4.

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November 01, 2018 Filed Nov 1, 2018 23:34 UTC
BENNETT C FRANKSVP, Antisense Research
Exercise / conversionCommon Stock 12,500 $14.69 $183,625.00
Disclosure

SEC source: 0000874015-18-000124 · edgar.xml · nonDerivative · entry 1

BENNETT C FRANK · CIK 0001073387 · SVP, Antisense Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,896

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 12/8/2017.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 12/8/2017.

Read SEC document
October 15, 2018 Filed Oct 16, 2018 00:55 UTC GrantRestricted Stock Units · Derivative 7,110 $0.00 $0.00
Disclosure

SEC source: 0000874015-18-000121 · edgar.xml · derivative · entry 1

Reikes Peter N · CIK 0001753652 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,110

Underlying: Common Stock · 7,110 shares

Expires not disclosed

F1 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F2 · derivative.exercise_date: Grant of October 15, 2018 to reporting person of Restricted Stock Unit Award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. Restricted Stock Units vest in four equal annual installments, the first installment vesting on October 15, 2019. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on October 15, 2022. The RSU is vested as to 0 shares on October 15, 2018.

F2 · derivative.expiration_date: Grant of October 15, 2018 to reporting person of Restricted Stock Unit Award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. Restricted Stock Units vest in four equal annual installments, the first installment vesting on October 15, 2019. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on October 15, 2022. The RSU is vested as to 0 shares on October 15, 2018.

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October 15, 2018 Filed Oct 16, 2018 00:51 UTC GrantRestricted Stock Units · Derivative 7,110 $0.00 $0.00
Disclosure

SEC source: 0000874015-18-000119 · edgar.xml · derivative · entry 1

Hayden Michael R · CIK 0001352908 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,110

Underlying: Common Stock · 7,110 shares

Expires not disclosed

F1 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of Ionis common stock, or its equivalent cash value.

F2 · derivative.exercise_date: Grant of October 15, 2018 to reporting person of Restricted Stock Unit Award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. Restricted Stock Units vest in four equal annual installments, the first installment vesting on October 15, 2019. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on October 15, 2022. The RSU is vested as to 0 shares on October 15, 2018.

F2 · derivative.expiration_date: Grant of October 15, 2018 to reporting person of Restricted Stock Unit Award under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. Restricted Stock Units vest in four equal annual installments, the first installment vesting on October 15, 2019. Upon vesting, the restricted stock units will be paid out in whole shares of Ionis common stock or cash as may be determined by the Company. The RSU shall be fully vested on October 15, 2022. The RSU is vested as to 0 shares on October 15, 2018.

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September 23, 2018 Filed Sep 25, 2018 00:04 UTC GrantDirector Stock Option (right to buy) · Derivative 32,000 $0.00 Strike: $49.14 $0.00
Disclosure

SEC source: 0000874015-18-000113 · edgar.xml · derivative · entry 1

Reikes Peter N · CIK 0001753652 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,000

Underlying: Common Stock · 32,000 shares

Expires 2028-09-22

F1 · derivative.exercise_date: Grant of September 23, 2018 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. The option vests and becomes exercisable in four equal annual installments, the first installment vesting on September 23, 2019. The option shall be fully vested and exercisable on September 23, 2022. The option is exercisable to 0 shares on September 23, 2018.

F1 · derivative.expiration_date: Grant of September 23, 2018 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. The option vests and becomes exercisable in four equal annual installments, the first installment vesting on September 23, 2019. The option shall be fully vested and exercisable on September 23, 2022. The option is exercisable to 0 shares on September 23, 2018.

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September 20, 2018 Filed Sep 25, 2018 00:14 UTC GrantDirector Stock Option (right to buy) · Derivative 32,000 $0.00 Strike: $50.80 $0.00
Disclosure

SEC source: 0000874015-18-000115 · edgar.xml · derivative · entry 1

Hayden Michael R · CIK 0001352908 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 32,000

Underlying: Common Stock · 32,000 shares

Expires 2028-09-19

F1 · derivative.exercise_date: Grant of September 20, 2018 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. The option vests and becomes exercisable in four equal annual installments, the first installment vesting on September 20, 2019. The option shall be fully vested and exercisable on September 20, 2022. The option is exercisable to 0 shares on September 20, 2018.

F1 · derivative.expiration_date: Grant of September 20, 2018 to reporting person of stock options under the Amended and Restated Ionis Pharmaceuticals, Inc. 2002 Non-Employee Directors' Stock Option Plan. The option vests and becomes exercisable in four equal annual installments, the first installment vesting on September 20, 2019. The option shall be fully vested and exercisable on September 20, 2022. The option is exercisable to 0 shares on September 20, 2018.

Read SEC document
August 27, 2018 Filed Aug 29, 2018 20:49 UTC
Monia Brett PChief Operating Officer
Exercise / conversionEmployee Stock Option (right to buy) · Derivative 7,500 $0.00 Strike: $7.21 $0.00
Disclosure

SEC source: 0000874015-18-000109 · edgar.xml · derivative · entry 6

Monia Brett P · CIK 0001537529 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 7,500 shares

Expires 2018-12-31

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
August 27, 2018 Filed Aug 29, 2018 20:49 UTC
Monia Brett PChief Operating Officer
Exercise / conversionEmployee Stock Option (right to buy) · Derivative 8,993 $0.00 Strike: $7.25 $0.00
Disclosure

SEC source: 0000874015-18-000109 · edgar.xml · derivative · entry 5

Monia Brett P · CIK 0001537529 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 8,993 shares

Expires 2019-01-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
August 27, 2018 Filed Aug 29, 2018 20:49 UTC
Monia Brett PChief Operating Officer
SaleCommon Stock 7,500 $54.00 $405,000.00
Disclosure

SEC source: 0000874015-18-000109 · edgar.xml · nonDerivative · entry 4

Monia Brett P · CIK 0001537529 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,841

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 5/11/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 5/11/2018.

Read SEC document
August 27, 2018 Filed Aug 29, 2018 20:49 UTC
Monia Brett PChief Operating Officer
Exercise / conversionCommon Stock 7,500 $7.21 $54,075.00
Disclosure

SEC source: 0000874015-18-000109 · edgar.xml · nonDerivative · entry 3

Monia Brett P · CIK 0001537529 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,341

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 5/11/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 5/11/2018.

Read SEC document
August 27, 2018 Filed Aug 29, 2018 20:49 UTC
Monia Brett PChief Operating Officer
SaleCommon Stock 8,993 $54.00 $485,622.00
Disclosure

SEC source: 0000874015-18-000109 · edgar.xml · nonDerivative · entry 2

Monia Brett P · CIK 0001537529 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,841

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 5/11/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 5/11/2018.

Read SEC document
August 27, 2018 Filed Aug 29, 2018 20:49 UTC
Monia Brett PChief Operating Officer
Exercise / conversionCommon Stock 8,993 $7.25 $65,199.25
Disclosure

SEC source: 0000874015-18-000109 · edgar.xml · nonDerivative · entry 1

Monia Brett P · CIK 0001537529 · Chief Operating Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,834

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 5/11/2018.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 5/11/2018.

Read SEC document
August 08, 2018 Filed Aug 9, 2018 22:34 UTC
BENNETT C FRANKSVP, Antisense Research
Exercise / conversionEmployee Stock Option (right to buy) · Derivative 12,487 $0.00 Strike: $14.69 $0.00
Disclosure

SEC source: 0000874015-18-000107 · edgar.xml · derivative · entry 6

BENNETT C FRANK · CIK 0001073387 · SVP, Antisense Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,513

Underlying: Common Stock · 12,487 shares

Expires 2020-01-29

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
August 08, 2018 Filed Aug 9, 2018 22:34 UTC
BENNETT C FRANKSVP, Antisense Research
Exercise / conversionEmployee Stock Option (right to buy) · Derivative 13 $0.00 Strike: $7.25 $0.00
Disclosure

SEC source: 0000874015-18-000107 · edgar.xml · derivative · entry 5

BENNETT C FRANK · CIK 0001073387 · SVP, Antisense Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 13 shares

Expires 2019-01-02

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

Read SEC document
August 08, 2018 Filed Aug 9, 2018 22:34 UTC
BENNETT C FRANKSVP, Antisense Research
SaleCommon Stock 12,487 $45.00 $561,915.00
Disclosure

SEC source: 0000874015-18-000107 · edgar.xml · nonDerivative · entry 4

BENNETT C FRANK · CIK 0001073387 · SVP, Antisense Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,396

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 12/8/2017.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 12/8/2017.

Read SEC document
August 08, 2018 Filed Aug 9, 2018 22:34 UTC
BENNETT C FRANKSVP, Antisense Research
Exercise / conversionCommon Stock 12,487 $14.69 $183,434.03
Disclosure

SEC source: 0000874015-18-000107 · edgar.xml · nonDerivative · entry 3

BENNETT C FRANK · CIK 0001073387 · SVP, Antisense Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,883

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 12/8/2017.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 12/8/2017.

Read SEC document
August 08, 2018 Filed Aug 9, 2018 22:34 UTC
BENNETT C FRANKSVP, Antisense Research
SaleCommon Stock 13 $45.00 $585.00
Disclosure

SEC source: 0000874015-18-000107 · edgar.xml · nonDerivative · entry 2

BENNETT C FRANK · CIK 0001073387 · SVP, Antisense Research

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,396

F1 · kind: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 12/8/2017.

F1 · shares: Acquired as a result of exercising a stock option pursuant to Rule 10b5-1 Trading Plan. The purchase and sale reported on this Form 4 was effective pursuant to Rule 10b5-1 Trading Plan adopted by the reporting person on 12/8/2017.

Read SEC document

Value uses the disclosed total when available, otherwise shares × reported transaction price. It is not an estimate of exercise cash cost or investment performance.