INSM

SEC source: 0001127430-19-000022 · edgar.xml · derivative · entry 1

Lewis William · CIK 0001402051 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 555,140

Underlying: Common Stock · 555,140 shares

Expires 2029-01-03

F1 · derivative.exercise_date: Stock options granted under the Company's 2017 Incentive Plan. The options become exercisable based on the following vesting schedule: twenty five percent (25%) on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001127430-19-000021 · edgar.xml · derivative · entry 1

SORIANO JOHN · CIK 0001740947 · Chief Compliance Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 138,790

Underlying: Common Stock · 138,790 shares

Expires 2029-01-03

F1 · derivative.exercise_date: Stock options granted under the Company's 2017 Incentive Plan. The options become exercisable based on the following vesting schedule: twenty-five percent (25%) on the first anniversary of the grant date and an additional twelve and one-half percent (12.5%) vest on the six month anniversary of the first anniversary date and each six month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001127430-19-000020 · edgar.xml · derivative · entry 2

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 157,290

Underlying: Common Stock · 157,290 shares

Expires 2029-01-03

F2 · derivative.exercise_date: Stock options granted under the Company's 2017 Incentive Plan. The options become exercisable based on the following vesting schedule: twenty five percent (25%) on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001127430-19-000019 · edgar.xml · derivative · entry 1

Pellizzari Christine A · CIK 0001127430 · Chief Legal Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 157,290

Underlying: Common Stock · 157,290 shares

Expires 2029-01-03

F1 · derivative.exercise_date: Stock options granted under the Company's 2017 Incentive Plan. The options become exercisable based on the following vesting schedule: twenty five percent (25%) on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001127430-19-000017 · edgar.xml · derivative · entry 1

Adsett Roger · CIK 0001685904 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 231,310

Underlying: Common Stock · 231,310 shares

Expires 2029-01-03

F1 · derivative.exercise_date: Stock options granted under the Company's 2017 Incentive Plan. The options become exercisable based on the following vesting schedule: twenty five percent (25%) on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001127430-19-000018 · edgar.xml · derivative · entry 1

TOMBESI PAOLO · CIK 0001707648 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 120,280

Underlying: Common Stock · 120,280 shares

Expires 2029-01-03

F1 · derivative.exercise_date: Stock options granted under the Company's 2017 Incentive Plan. The options become exercisable based on the following vesting schedule: twenty-five percent (25%) on the first anniversary of the grant date and an additional twelve and one-half percent (12.5%) vest on the six month anniversary of the first anniversary date and each six month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001127430-18-000078 · edgar.xml · nonDerivative · entry 3

SHAROKY MELVIN MD · CIK 0001182633 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by family LLC

Disclosed balance after: 20,000

F2 · price: The price in column 4 is a weighted average price. The prices actually paid by the Reporting Person in these transactions range from $15.57 to $15.59. The number of shares sold at each separate price will be made available to the SEC staff, the issuer or a security holder of the issuer upon request.

F3 · ownership.nature: The reporting person has sole voting control of the LLC, but shares ownership with certain family members.

SEC source: 0001127430-18-000078 · edgar.xml · nonDerivative · entry 2

SHAROKY MELVIN MD · CIK 0001182633 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by family LLC

Disclosed balance after: 11,205

F3 · ownership.nature: The reporting person has sole voting control of the LLC, but shares ownership with certain family members.

SEC source: 0001127430-18-000078 · edgar.xml · nonDerivative · entry 1

SHAROKY MELVIN MD · CIK 0001182633 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by family LLC

Disclosed balance after: 10,000

F1 · price: The price in column 4 is a weighted average price. The prices actually paid by the Reporting Person in these transactions range from $16.31 to $16.40. The number of shares sold at each separate price will be made available to the SEC staff, the issuer or a security holder of the issuer upon request.

F3 · ownership.nature: The reporting person has sole voting control of the LLC, but shares ownership with certain family members.

SEC source: 0001127430-18-000074 · edgar.xml · nonDerivative · entry 1

ANDERSON ELIZABETH M · CIK 0001758247 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 5,118

F1 · shares: The Restricted Stock Units have a one year cliff vesting period, provided that the director (a) remains a member of the Board on such vesting date, and (b) attends at least 75% of the meetings of the Board which take place between the grant date and the first anniversary of the grant date. Vested shares are delivered within 30 days of vesting date.

F2 · price: Each Restricted Stock Unit was granted on November 6, 2018, for no consideration, and represents a contingent right to receive one share of Common Stock.

SEC source: 0001127430-18-000068 · edgar.xml · nonDerivative · entry 1

ENGELSEN STEINAR J · CIK 0001218860 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 281,303

F1 · price: This transaction was executed in multiple trades at prices ranging from $15.60 to $15.93. The price reported above reflect the weighted average price. The number of shares sold at each separate price will be made available to the SEC staff, the issuer or a security holder of the issuer upon request.

SEC source: 0001127430-18-000066 · edgar.xml · nonDerivative · entry 1

Lewis William · CIK 0001402051 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 151,247

F1 · price: This transaction was executed in multiple trades at prices ranging from $15.7851 to $16.00. The prices reported above reflects the weighted average price. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001127430-18-000067 · edgar.xml · nonDerivative · entry 1

Adsett Roger · CIK 0001685904 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 18,594

F1 · price: This transaction was executed in multiple trades at prices ranging from $15.95 to $15.98. The prices reported above reflect the weighted average price. The number of shares sold at each separate price will be made available to the SEC staff, the issuer or a security holder of the issuer upon request.

SEC source: 0001127430-18-000061 · edgar.xml · derivative · entry 1

Lewis William · CIK 0001402051 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 83,333

Underlying: Common Stock · 83,333 shares

Expires 2023-05-23

F1 · derivative.underlying_shares: On May 23, 2013, the reporting person was granted an option to purchase 166,667 shares of common stock. The option vests in two installments based upon the Issuer's satisfaction of two separate performance metrics. The first installment vested on February 26, 2015. The performance metric applicable to the second installment, the first written approval of a New Drug Application or Marketing Authorization Application from the Food and Drug Administration of European Medicines Agency, respectively, was met on September 28, 2018, resulting in the vesting of the second installment.

SEC source: 0001127430-18-000060 · edgar.xml · derivative · entry 1

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,500

Underlying: Common Stock · 12,500 shares

Expires 2023-05-23

F1 · derivative.underlying_shares: On May 23, 2013, the reporting person was granted an option to purchase 25,000 shares of common stock. The option vests in two installments based upon the Issuer's satisfaction of two separate performance metrics. The first installment vested on February 26, 2015. The performance metric applicable to the second installment, the first written approval of a New Drug Application or Marketing Authorization Application from the Food and Drug Administration of European Medicines Agency, respectively, was met on September 28, 2018, resulting in the vesting of the second installment.

SEC source: 0001127430-18-000054 · edgar.xml · nonDerivative · entry 1

STRECK PAUL · CIK 0001708063 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,996

F1 · shares: Restricted stock units granted pursuant to the Company's 2017 Incentive Plan. The Restricted Stock Units vest and become available as follows: twenty five (25%) percent on each anniversary of the date of grant through the fourth anniversary date of the grant.

F2 · price: Each Restricted Stock Unit was received as a grant on August 8, 2018, for no consideration, and represents a contingent right to receive one share of Common Stock.

SEC source: 0001127430-18-000050 · edgar.xml · derivative · entry 6

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,575

Underlying: Common Stock · 25,991 shares

Expires 2026-05-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Stock options granted under the Company's 2015 Incentive Plan. The options become exercisable based on the following vesting schedule: twenty-five percent (25%) vest on the first anniversary of the grant date and an additional twelve and one-half percent (12.5%) vest on the six month anniversary of the first anniversary date and each six month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001127430-18-000050 · edgar.xml · nonDerivative · entry 4

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,669

F2 · price: This is the weighted average sales price representing 25,991 shares sold at prices ranging from $28.00 to $28.32 per share. The number sold at each price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.

SEC source: 0001127430-18-000050 · edgar.xml · nonDerivative · entry 3

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,660

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127430-18-000050 · edgar.xml · derivative · entry 5

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 63,566

Underlying: Common Stock · 11,584 shares

Expires 2026-05-19

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: Stock options granted under the Company's 2015 Incentive Plan. The options become exercisable based on the following vesting schedule: twenty-five percent (25%) vest on the first anniversary of the grant date and an additional twelve and one-half percent (12.5%) vest on the six month anniversary of the first anniversary date and each six month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001127430-18-000050 · edgar.xml · nonDerivative · entry 2

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,669

F1 · price: This is the weighted average sales price representing 11,584 shares sold at prices ranging from $27.60 to $27.84 per share. The number sold at each price will be made available to the SEC staff, the issuer, or a security holder of the issuer upon request.

SEC source: 0001127430-18-000050 · edgar.xml · nonDerivative · entry 1

Schaeffer Orlov S Nicole · CIK 0001401017 · Chief People Strategy Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 22,253

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001127430-18-000042 · edgar.xml · nonDerivative · entry 1

POTTER MYRTLE S · CIK 0001214130 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,510

F1 · shares: The Restricted Stock Units have a one year cliff vesting period, provided that the director (a) remains a member of the Board on such vesting date, and (b) attends at least 75% of the meetings of the Board which take place between the grant date and the first anniversary of the grant date. Vested shares are delivered within 30 days of vesting date.

F2 · price: Each Restricted Stock Unit was granted on May 15, 2018, and represents a contingent right to receive one share of Common Stock.

SEC source: 0001127430-18-000041 · edgar.xml · nonDerivative · entry 1

MCGIRR DAVID W J · CIK 0001219023 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 35,362

F1 · shares: The Restricted Stock Units have a one year cliff vesting period, provided that the director (a) remains a member of the Board on such vesting date, and (b) attends at least 75% of the meetings of the Board which take place between the grant date and the first anniversary of the grant date. Vested shares are delivered within 30 days of vesting date.

F2 · price: Each Restricted Stock Unit was granted on May 15, 2018, and represents a contingent right to receive one share of Common Stock.

SEC source: 0001127430-18-000040 · edgar.xml · nonDerivative · entry 1

HAYDEN DONALD J JR · CIK 0001202285 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 62,197

F1 · shares: The Restricted Stock Units have a one year cliff vesting period, provided that the director (a) remains a member of the Board on such vesting date, and (b) attends at least 75% of the meetings of the Board which take place between the grant date and the first anniversary of the grant date. Vested shares are delivered within 30 days of vesting date.

F2 · price: Each Restricted Stock Unit was granted on May 15, 2018, and represents a contingent right to receive one share of Common Stock.

SEC source: 0001127430-18-000039 · edgar.xml · nonDerivative · entry 1

ENGELSEN STEINAR J · CIK 0001218860 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 265,218

F1 · shares: The Restricted Stock Units have a one year cliff vesting period, provided that the director (a) remains a member of the Board on such vesting date, and (b) attends at least 75% of the meetings of the Board which take place between the grant date and the first anniversary of the grant date. Vested shares are delivered within 30 days of vesting date.

F2 · price: Each Restricted Stock Unit granted on May 15, 2018, and represents a contingent right to receive one share of Common Stock.

SEC source: 0001127430-18-000038 · edgar.xml · nonDerivative · entry 1

Brennan David R · CIK 0001609305 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,322

F1 · shares: The Restricted Stock Units have a one year cliff vesting period, provided that the director (a) remains a member of the Board on such vesting date, and (b) attends at least 75% of the meetings of the Board which take place between the grant date and the first anniversary of the grant date. Vested shares are delivered within 30 days of vesting date.

F2 · price: Each Restricted Stock Unit was granted on May 15, 2018, and represents a contingent right to receive one share of Common Stock.

SEC source: 0001127430-18-000037 · edgar.xml · nonDerivative · entry 1

ALTOMARI ALFRED · CIK 0001285644 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 47,942

F1 · shares: The Restricted Stock Units have a one year cliff vesting period, provided that the director (a) remains a member of the Board on such vesting date, and (b) attends at least 75% of the meetings of the Board which take place between the grant date and the first anniversary of the grant date. Vested shares are delivered within 30 days of vesting date.

F2 · price: Each Restricted Stock Unit was granted on May 15, 2018, and represents a contingent right to receive one share of Common Stock.

SEC source: 0001127430-18-000036 · edgar.xml · nonDerivative · entry 1

LEE LEO · CIK 0001740789 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,066

F1 · shares: The Restricted Stock Units have a one year cliff vesting period, provided that the director (a) remains a member of the Board on such vesting date, and (b) attends at least 75% of the meetings of the Board which take place between the grant date and the first anniversary of the grant date. Vested shares are delivered within 30 days of vesting date.

F2 · price: Each Restricted Stock Unit was granted on May 15, 2018, for no consideration, and represents a contingent right to receive one share of Common Stock.

SEC source: 0001127430-18-000021 · edgar.xml · derivative · entry 2

TOMBESI PAOLO · CIK 0001707648 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 55,400

Underlying: Common Stock · 55,400 shares

Expires 2028-01-04

F3 · derivative.exercise_date: Stock options granted under the Company's 2017 Incentive Plan. The options become exercisable based on the following vesting schedule: twenty-five percent (25%) on the first anniversary of the grant date and an additional twelve and one-half percent (12.5%) vest on the six month anniversary of the first anniversary date and each six month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001127430-18-000021 · edgar.xml · nonDerivative · entry 1

TOMBESI PAOLO · CIK 0001707648 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,669

F1 · shares: Restricted stock units granted pursuant to the Company's 2017 Incentive Plan. The Restricted Stock Units vest and become available as follows: twenty five (25%) percent on each anniversary of the date of grant through the fourth anniversary date of the grant.

F2 · price: Each Restricted Stock Unit was received as a grant on January 4, 2018, for no consideration, and represents a contingent right to receive one share of Common Stock.

SEC source: 0001127430-18-000020 · edgar.xml · derivative · entry 2

Schaeffer Orlov S Nicole · CIK 0001401017 · SVP, HR & Corp. Svcs.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 55,400

Underlying: Common Stock · 55,400 shares

Expires 2028-01-04

F3 · derivative.exercise_date: Stock options granted under the Company's 2017 Incentive Plan. The options become exercisable based on the following vesting schedule: twenty five percent (25%) on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001127430-18-000020 · edgar.xml · nonDerivative · entry 1

Schaeffer Orlov S Nicole · CIK 0001401017 · SVP, HR & Corp. Svcs.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,669

F1 · shares: Restricted stock units granted pursuant to the Company's 2017 Incentive Plan. The Restricted Stock Units vest and become available as follows: twenty five (25%) percent on each anniversary of the date of grant through the fourth anniversary date of the grant.

F2 · price: Each Restricted Stock Unit was received as a grant on January 4, 2018, for no consideration, and represents a contingent right to receive one share of Common Stock.

SEC source: 0001127430-18-000018 · edgar.xml · derivative · entry 2

Pellizzari Christine A · CIK 0001127430 · General Counsel & Corp. Sec.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 55,400

Underlying: Common Stock · 55,400 shares

Expires 2028-01-04

F3 · derivative.exercise_date: Stock options granted under the Company's 2017 Incentive Plan. The options become exercisable based on the following vesting schedule: twenty five percent (25%) on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001127430-18-000018 · edgar.xml · nonDerivative · entry 1

Pellizzari Christine A · CIK 0001127430 · General Counsel & Corp. Sec.

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,669

F1 · shares: Restricted stock units granted pursuant to the Company's 2017 Incentive Plan. The Restricted Stock Units vest and become available as follows: twenty five (25%) percent on each anniversary of the date of grant through the fourth anniversary date of the grant.

F2 · price: Each Restricted Stock Unit was received as a grant on January 4, 2018, for no consideration, and represents a contingent right to receive one share of Common Stock.

SEC source: 0001127430-18-000016 · edgar.xml · derivative · entry 2

Adsett Roger · CIK 0001685904 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,970

Underlying: Common Stock · 80,970 shares

Expires 2028-01-04

F3 · derivative.exercise_date: Stock options granted under the Company's 2017 Incentive Plan. The options become exercisable based on the following vesting schedule: twenty five percent (25%) on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001127430-18-000016 · edgar.xml · nonDerivative · entry 1

Adsett Roger · CIK 0001685904 · Chief Commercial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,594

F1 · shares: Restricted stock units granted pursuant to the Company's 2017 Incentive Plan. The Restricted Stock Units vest and become available as follows: twenty five (25%) percent on each anniversary of the date of grant through the fourth anniversary date of the grant.

F2 · price: Each Restricted Stock Unit was received as a grant on January 4, 2018, for no consideration, and represents a contingent right to receive one share of Common Stock.

SEC source: 0001127430-18-000017 · edgar.xml · derivative · entry 2

Lewis William · CIK 0001402051 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 200,290

Underlying: Common Stock · 200,290 shares

Expires 2028-01-04

F3 · derivative.exercise_date: Stock options granted under the Company's 2017 Incentive Plan. The options become exercisable based on the following vesting schedule: twenty five percent (25%) on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001127430-18-000017 · edgar.xml · nonDerivative · entry 1

Lewis William · CIK 0001402051 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 135,547

F1 · shares: Restricted stock units granted pursuant to the Company's 2017 Incentive Plan. The Restricted Stock Units vest and become available as follows: twenty five (25%) percent on each anniversary of the date of grant through the fourth anniversary date of the grant.

F2 · price: Each Restricted Stock Unit was received as a grant on January 4, 2018, for no consideration, and represents a contingent right to receive one share of Common Stock.

SEC source: 0001127430-18-000019 · edgar.xml · derivative · entry 2

STRECK PAUL · CIK 0001708063 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 59,660

Underlying: Common Stock · 59,660 shares

Expires 2028-01-04

F3 · derivative.exercise_date: Stock options granted under the Company's 2017 Incentive Plan. The options become exercisable based on the following vesting schedule: twenty-five percent (25%) on the first anniversary of the grant date and an additional twelve and one-half percent (12.5%) vest on the six month anniversary of the first anniversary date and each six month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001127430-18-000019 · edgar.xml · nonDerivative · entry 1

STRECK PAUL · CIK 0001708063 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,490

F1 · shares: Restricted stock units granted pursuant to the Company's 2017 Incentive Plan. The Restricted Stock Units vest and become available as follows: twenty five (25%) percent on each anniversary of the date of grant through the fourth anniversary date of the grant.

F2 · price: Each Restricted Stock Unit was received as a grant on January 4, 2018, for no consideration, and represents a contingent right to receive one share of Common Stock.

SEC source: 0001127430-17-000085 · edgar.xml · derivative · entry 3

HAYDEN DONALD J JR · CIK 0001202285 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 15,000 shares

Expires 2021-12-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Stock options granted on December 21, 2011 under the Company's 2000 Stock Incentive Plan. The options became exercisable based on the following vesting schedule: twenty five percent (25%) on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each six month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001127430-17-000085 · edgar.xml · nonDerivative · entry 2

HAYDEN DONALD J JR · CIK 0001202285 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,131

F1 · kind: The exercise of stock options and sales reported in this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001127430-17-000085 · edgar.xml · nonDerivative · entry 1

HAYDEN DONALD J JR · CIK 0001202285 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 71,131

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise of stock options and sales reported in this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001127430-17-000078 · edgar.xml · derivative · entry 9

HAYDEN DONALD J JR · CIK 0001202285 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 15,000 shares

Expires 2021-12-21

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_date: Stock options granted on December 21, 2011 under the Company's 2000 Stock Incentive Plan. The options became exercisable based on the following vesting schedule: twenty five percent (25%) on the first anniversary of the grant date and an additional twelve and one half percent (12.5%) vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001127430-17-000078 · edgar.xml · nonDerivative · entry 6

HAYDEN DONALD J JR · CIK 0001202285 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,131

F1 · kind: The exercise of stock options and sales reported in this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001127430-17-000078 · edgar.xml · nonDerivative · entry 5

HAYDEN DONALD J JR · CIK 0001202285 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 71,131

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercise of stock options and sales reported in this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001127430-17-000079 · edgar.xml · nonDerivative · entry 5

SHAROKY MELVIN MD · CIK 0001182633 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 225,728

F1 · kind: The sales reported in this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F6 · price: The price in column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $25.50 to $25.88, inclusive.

SEC source: 0001127430-17-000079 · edgar.xml · nonDerivative · entry 4

SHAROKY MELVIN MD · CIK 0001182633 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 241,936

F1 · kind: The sales reported in this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F5 · price: The price in column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $25.89 to $26.40, inclusive.

SEC source: 0001127430-17-000079 · edgar.xml · nonDerivative · entry 3

SHAROKY MELVIN MD · CIK 0001182633 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 250,728

F1 · kind: The sales reported in this Form 4 were effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F4 · price: The price in column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $29.21 to $29.50, inclusive.