INSM

SEC source: 0001609305-26-000009 · wk-form4_1789157083.xml · nonDerivative · entry 1

Brennan David R · CIK 0001609305 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 39,238

SEC source: 0001182633-26-000010 · wk-form4_1787170216.xml · nonDerivative · entry 1

SHAROKY MELVIN MD · CIK 0001182633 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Padonia, LLC

Disclosed balance after: 0

F1 · price: This is the weighted average sales price representing 5,000 shares sold at prices ranging from $127.51 to $127.61 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

F2 · ownership.nature: The Reporting Person is the managing member of Padonia, LLC.

SEC source: 0001685904-26-000014 · wk-form4_1786568667.xml · derivative · entry 7

Adsett Roger · CIK 0001685904 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 80,970 shares

Expires 2028-01-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: 25% vested on the first anniversary of the grant date and an additional 12.5% vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001685904-26-000014 · wk-form4_1786568667.xml · derivative · entry 6

Adsett Roger · CIK 0001685904 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 76,600 shares

Expires 2027-05-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: 25% vested on the first anniversary of the grant date and an additional 12.5% vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001685904-26-000014 · wk-form4_1786568667.xml · derivative · entry 5

Adsett Roger · CIK 0001685904 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 82,280 shares

Expires 2027-01-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: 25% vested on the first anniversary of the grant date and an additional 12.5% vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001685904-26-000014 · wk-form4_1786568667.xml · nonDerivative · entry 4

Adsett Roger · CIK 0001685904 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 98,744

F2 · price: This is the weighted average sales price representing 239,850 shares sold at prices ranging from $133.00 to $133.51 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001685904-26-000014 · wk-form4_1786568667.xml · nonDerivative · entry 3

Adsett Roger · CIK 0001685904 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 338,594

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001685904-26-000014 · wk-form4_1786568667.xml · nonDerivative · entry 2

Adsett Roger · CIK 0001685904 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 257,624

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001685904-26-000014 · wk-form4_1786568667.xml · nonDerivative · entry 1

Adsett Roger · CIK 0001685904 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 181,024

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 141 shares acquired through the Company's 2018 Employee Stock Purchase Plan.

SEC source: 0001796960-26-000020 · wk-form4_1786135147.xml · derivative · entry 6

Flammer Martina M.D. · CIK 0001796960 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 35,580

Underlying: Common Stock · 8,895 shares

Expires 2034-05-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on February 27, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F4 · derivative.exercise_date: The options become exercisable based on the following vesting schedule: 25% vest on the first day of the first month following the first anniversary of the date of grant (the Initial Vesting Date) and 12.5% vest on each sixth month anniversary date thereafter through the fourth anniversary of the Initial Vesting Date.

SEC source: 0001796960-26-000020 · wk-form4_1786135147.xml · derivative · entry 5

Flammer Martina M.D. · CIK 0001796960 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 36,555

Underlying: Common Stock · 18,278 shares

Expires 2033-05-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on February 27, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F3 · derivative.exercise_date: The options become exercisable based on the following vesting schedule: 25% vest on the first anniversary of the grant date and an additional 12.5% vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001796960-26-000020 · wk-form4_1786135147.xml · nonDerivative · entry 4

Flammer Martina M.D. · CIK 0001796960 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 60,486

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on February 27, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F2 · price: This is the weighted average sales price representing 18,278 shares sold at prices ranging from $129.40 to $129.41 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001796960-26-000020 · wk-form4_1786135147.xml · nonDerivative · entry 3

Flammer Martina M.D. · CIK 0001796960 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 78,764

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on February 27, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001796960-26-000020 · wk-form4_1786135147.xml · nonDerivative · entry 2

Flammer Martina M.D. · CIK 0001796960 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 87,659

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on February 27, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001796960-26-000020 · wk-form4_1786135147.xml · nonDerivative · entry 1

Flammer Martina M.D. · CIK 0001796960 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 78,764

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on February 27, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001402051-26-000042 · wk-form4_1784926946.xml · derivative · entry 7

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 4,440 shares

Expires 2027-05-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F4 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: 25% vested on the first anniversary of the grant date and an additional 12.5% vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001402051-26-000042 · wk-form4_1784926946.xml · derivative · entry 6

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 6,260 shares

Expires 2028-01-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F4 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: 25% vested on the first anniversary of the grant date and an additional 12.5% vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001402051-26-000042 · wk-form4_1784926946.xml · nonDerivative · entry 4

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 259,058

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F3 · price: This is the weighted average sales price representing 5,872 shares sold at prices ranging from $106.09 to $106.78 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001402051-26-000042 · wk-form4_1784926946.xml · nonDerivative · entry 3

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 264,930

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F2 · price: This is the weighted average sales price representing 4,828 shares sold at prices ranging from $105.09 to $106.02 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001402051-26-000042 · wk-form4_1784926946.xml · nonDerivative · entry 2

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 269,758

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001402051-26-000042 · wk-form4_1784926946.xml · nonDerivative · entry 1

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 265,318

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001402051-26-000040 · wk-form4_1783713769.xml · derivative · entry 8

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,440

Underlying: Common Stock · 4,440 shares

Expires 2027-05-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F6 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: 25% vested on the first anniversary of the grant date and an additional 12.5% vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001402051-26-000040 · wk-form4_1783713769.xml · derivative · entry 7

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 6,260

Underlying: Common Stock · 6,259 shares

Expires 2028-01-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F6 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: 25% vested on the first anniversary of the grant date and an additional 12.5% vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001402051-26-000040 · wk-form4_1783713769.xml · nonDerivative · entry 5

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 259,058

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F5 · price: This is the weighted average sales price representing 3,359 shares sold at prices ranging from $118.06 to $118.80 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001402051-26-000040 · wk-form4_1783713769.xml · nonDerivative · entry 4

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 262,417

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F4 · price: This is the weighted average sales price representing 2,335 shares sold at prices ranging from $117.05 to $117.96 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001402051-26-000040 · wk-form4_1783713769.xml · nonDerivative · entry 3

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 264,752

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F3 · price: This is the weighted average sales price representing 5,005 shares sold at prices ranging from $116.01 to $117.00 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001402051-26-000040 · wk-form4_1783713769.xml · nonDerivative · entry 2

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 269,757

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001402051-26-000040 · wk-form4_1783713769.xml · nonDerivative · entry 1

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 265,317

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F2 · balance_after: Includes 141 shares acquired through the Company's 2018 Employee Stock Purchase Plan.

SEC source: 0001796960-26-000018 · wk-form4_1783541018.xml · derivative · entry 6

Flammer Martina M.D. · CIK 0001796960 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 4,358

Underlying: Common Stock · 4,357 shares

Expires 2033-01-05

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on February 27, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F4 · derivative.exercise_date: The options become exercisable based on the following vesting schedule: 25% vest on the first anniversary of the grant date and an additional 12.5% vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001796960-26-000018 · wk-form4_1783541018.xml · derivative · entry 5

Flammer Martina M.D. · CIK 0001796960 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 23,835

Underlying: Common Stock · 7,945 shares

Expires 2034-01-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on February 27, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F4 · derivative.exercise_date: The options become exercisable based on the following vesting schedule: 25% vest on the first anniversary of the grant date and an additional 12.5% vest on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001796960-26-000018 · wk-form4_1783541018.xml · nonDerivative · entry 4

Flammer Martina M.D. · CIK 0001796960 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 60,486

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on February 27, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F3 · price: This is the weighted average sales price representing 7,448 shares sold at prices ranging from $110.36 to $110.71 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001796960-26-000018 · wk-form4_1783541018.xml · nonDerivative · entry 3

Flammer Martina M.D. · CIK 0001796960 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 67,934

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on February 27, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F2 · price: This is the weighted average sales price representing 4,854 shares sold at prices ranging from $108.90 to $109.58 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001796960-26-000018 · wk-form4_1783541018.xml · nonDerivative · entry 2

Flammer Martina M.D. · CIK 0001796960 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 72,788

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on February 27, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001796960-26-000018 · wk-form4_1783541018.xml · nonDerivative · entry 1

Flammer Martina M.D. · CIK 0001796960 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 68,431

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on February 27, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001402051-26-000038 · wk-form4_1782504217.xml · derivative · entry 10

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 8,880

Underlying: Common Stock · 8,880 shares

Expires 2027-05-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F7 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: 25% vested on the first anniversary of the grant date and an additional 12.5% vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001402051-26-000038 · wk-form4_1782504217.xml · derivative · entry 9

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 12,519

Underlying: Common Stock · 12,518 shares

Expires 2028-01-04

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F7 · derivative.exercise_date: The options became exercisable based on the following vesting schedule: 25% vested on the first anniversary of the grant date and an additional 12.5% vested on each sixth month anniversary date thereafter through the fourth anniversary of the date of grant.

SEC source: 0001402051-26-000038 · wk-form4_1782504217.xml · nonDerivative · entry 7

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 258,917

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F6 · price: This is the weighted average sales price representing 1,292 shares sold at prices ranging from $105.90 to $106.45 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001402051-26-000038 · wk-form4_1782504217.xml · nonDerivative · entry 6

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 260,209

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F5 · price: This is the weighted average sales price representing 2,456 shares sold at prices ranging from $104.90 to $105.88 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001402051-26-000038 · wk-form4_1782504217.xml · nonDerivative · entry 5

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 262,665

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F4 · price: This is the weighted average sales price representing 3,723 shares sold at prices ranging from $103.87 to $104.75 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001402051-26-000038 · wk-form4_1782504217.xml · nonDerivative · entry 4

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 266,388

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F3 · price: This is the weighted average sales price representing 1,836 shares sold at prices ranging from $102.78 to $103.58 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001402051-26-000038 · wk-form4_1782504217.xml · nonDerivative · entry 3

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 268,224

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

F2 · price: This is the weighted average sales price representing 12,091 shares sold at prices ranging from $101.78 to $102.77 per share. The Reporting Person undertakes to provide to the SEC staff, the issuer, or a security holder of the issuer the number of shares sold at each price within the price range upon request.

SEC source: 0001402051-26-000038 · wk-form4_1782504217.xml · nonDerivative · entry 2

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 280,315

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001402051-26-000038 · wk-form4_1782504217.xml · nonDerivative · entry 1

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 271,435

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0002140098-26-000005 · wk-form4_1782332113.xml · derivative · entry 2

Butera Samuele · CIK 0002140098 · SVP, GM, Global Respiratory

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,570

Underlying: Common Stock · 12,570 shares

Expires 2036-06-23

F3 · derivative.exercise_date: These stock options were granted under the Company's Amended and Restated 2019 Incentive Plan, as amended. The options become exercisable based on the following vesting schedule: 25% vest on the Initial Vesting Date and an additional 12.5% vest every six months thereafter until fully vested.

SEC source: 0002140098-26-000005 · wk-form4_1782332113.xml · nonDerivative · entry 1

Butera Samuele · CIK 0002140098 · SVP, GM, Global Respiratory

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,342

F1 · shares: Represents Restricted Stock Units (RSUs), each representing a contingent right to receive one share of Common Stock, granted pursuant to the Company's Amended and Restated 2019 Incentive Plan, as amended. The RSUs vest as follows: 25% on the first day of the first month following the first anniversary of the date of grant (the Initial Vesting Date) and 25% on each anniversary of the Initial Vesting Date until fully vested.

F2 · price: Each RSU was granted on June 23, 2026, for no consideration.

SEC source: 0001870278-26-000020 · wk-form4_1782331897.xml · nonDerivative · entry 1

Smith Michael Alexander · CIK 0001870278 · Chief Legal Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 37,648

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on November 7, 2025, in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001402051-26-000035 · wk-form4_1781121933.xml · nonDerivative · entry 1

Lewis William · CIK 0001402051 · Director · Chair and CEO

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 258,917

F1 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on September 4, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001796960-26-000016 · wk-form4_1780690310.xml · nonDerivative · entry 2

Flammer Martina M.D. · CIK 0001796960 · Chief Medical Officer

10b5-1 filing: Plan reported

Ownership: Direct

Disclosed balance after: 60,486

F2 · kind: This transaction was effected pursuant to a 10b5-1 trading plan adopted by the Reporting Person on February 27, 2025 in accordance with Rule 10b5-1 of the Securities Exchange Act of 1934, as amended.

SEC source: 0001685904-26-000012 · wk-form4_1780690556.xml · nonDerivative · entry 1

Adsett Roger · CIK 0001685904 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 98,603

F1 · kind: Shares sold to satisfy tax withholding obligations upon the vesting of Restricted Stock Units and to cover related broker fees.

SEC source: 0001604019-26-000010 · wk-form4_1780690483.xml · nonDerivative · entry 1

Bonstein Sara · CIK 0001604019 · Chief Financial Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 69,082

F1 · kind: Shares sold to satisfy tax withholding obligations upon the vesting of Restricted Stock Units and to cover related broker fees.