DSGN

SEC source: 0001478916-26-000009 · form4-06112026_040611.xml · derivative · entry 1

Schmid John P. · CIK 0001478916 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2036-06-08

F1 · derivative.exercise_date: The shares subject to the option vest in equal monthly installments over 12 months following June 9, 2026 provided that the shares subject to the option will in any case be fully vested on the date of the Company's next annual meeting of stockholders.

SEC source: 0001193125-26-267732 · ownership.xml · derivative · entry 1

George Simeon · CIK 0001595117 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2036-06-08

F1 · derivative.exercise_date: The shares subject to the option vest in equal monthly installments over 12 months following June 9, 2026 provided that the shares subject to the option will in any case be fully vested on the date of the Company's next annual meeting of stockholders.

SEC source: 0001579826-26-000002 · form4-06112026_040609.xml · derivative · entry 1

LAPPE RODNEY W · CIK 0001579826 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2036-06-08

F1 · derivative.exercise_date: The shares subject to the option vest in equal monthly installments over 12 months following June 9, 2026 provided that the shares subject to the option will in any case be fully vested on the date of the Company's next annual meeting of stockholders.

SEC source: 0001559570-26-000008 · form4-06112026_040613.xml · derivative · entry 1

Shapiro David · CIK 0001559570 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2036-06-08

F1 · derivative.exercise_date: The shares subject to the option vest in equal monthly installments over 12 months following June 9, 2026 provided that the shares subject to the option will in any case be fully vested on the date of the Company's next annual meeting of stockholders.

SEC source: 0001754129-26-000006 · form4-06112026_040607.xml · derivative · entry 1

Gover Justin D. · CIK 0001754129 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2036-06-08

F1 · derivative.exercise_date: The shares subject to the option vest in equal monthly installments over 12 months following June 9, 2026 provided that the shares subject to the option will in any case be fully vested on the date of the Company's next annual meeting of stockholders.

SEC source: 0001751873-26-000002 · form4-06112026_040606.xml · derivative · entry 1

Berger Heather A. · CIK 0001751873 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2036-06-08

F1 · derivative.exercise_date: The shares subject to the option vest in equal monthly installments over 12 months following June 9, 2026 provided that the shares subject to the option will in any case be fully vested on the date of the Company's next annual meeting of stockholders.

SEC source: 0001559570-26-000006 · form4-04012026_080415.xml · derivative · entry 2

Shapiro David · CIK 0001559570 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 7,500

Underlying: Common Stock · 7,500 shares

Expires 2036-03-30

F2 · derivative.exercise_date: The shares subject to the option will vest in equal monthly installments over 12 months following March 31, 2026.

SEC source: 0001559570-26-000006 · form4-04012026_080415.xml · derivative · entry 1

Shapiro David · CIK 0001559570 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 60,000

Underlying: Common Stock · 60,000 shares

Expires 2036-03-30

F1 · derivative.exercise_date: The shares subject to the option will vest in equal monthly installments over 36 months following March 31, 2026.

SEC source: 0001674703-26-000002 · form4-01052026_090112.xml · derivative · entry 1

Storgard Chris · CIK 0001674703 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 250,000

Underlying: Common Stock · 250,000 shares

Expires 2036-01-01

F1 · derivative.exercise_date: The shares subject to the option will vest as follows: 20% of the shares will vest on January 1, 2027, 20% of the shares will vest in equal monthly installments over the following 12 months, 30% of the shares will vest in equal monthly installments over the following 12 months, and 30% of the shares will vest in equal monthly installments over the following 12 months.

SEC source: 0001848377-26-000002 · form4-01052026_090157.xml · derivative · entry 1

Jeffries Sean · CIK 0001848377 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 375,000

Underlying: Common Stock · 375,000 shares

Expires 2036-01-01

F1 · derivative.exercise_date: The shares subject to the option will vest as follows: 20% of the shares will vest on January 1, 2027, 20% of the shares will vest in equal monthly installments over the following 12 months, 30% of the shares will vest in equal monthly installments over the following 12 months, and 30% of the shares will vest in equal monthly installments over the following 12 months.

SEC source: 0001883722-26-000002 · form4-01052026_090130.xml · derivative · entry 1

Burgess Julie · CIK 0001883722 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 150,000

Underlying: Common Stock · 150,000 shares

Expires 2036-01-01

F1 · derivative.exercise_date: The shares subject to the option will vest as follows: 20% of the shares will vest on January 1, 2027, 20% of the shares will vest in equal monthly installments over the following 12 months, 30% of the shares will vest in equal monthly installments over the following 12 months, and 30% of the shares will vest in equal monthly installments over the following 12 months.

SEC source: 0001754129-26-000002 · form4-01052026_090117.xml · derivative · entry 1

Gover Justin D. · CIK 0001754129 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Common Stock · 45,000 shares

Expires 2036-01-01

F1 · derivative.exercise_date: The shares subject to the option will vest in equal monthly installments over 36 months following September 9, 2025.

SEC source: 0001580787-26-000002 · form4-01052026_090147.xml · derivative · entry 1

Shah Pratik · CIK 0001580787 · Director · President, CEO and Chairperson

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 750,000

Underlying: Common Stock · 750,000 shares

Expires 2036-01-01

F1 · derivative.exercise_date: The shares subject to the option will vest as follows: 20% of the shares will vest on January 1, 2027, 20% of the shares will vest in equal monthly installments over the following 12 months, 30% of the shares will vest in equal monthly installments over the following 12 months, and 30% of the shares will vest in equal monthly installments over the following 12 months.

SEC source: 0001580787-25-000006 · form4-12112025_041203.xml · derivative · entry 2

Shah Pratik · CIK 0001580787 · Director · President, CEO and Chairperson

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 525,000

Underlying: Common Stock · 525,000 shares

Expires not disclosed

F1 · derivative.exercise_date: On September 1, 2023, the Reporting Person was granted an option to purchase 525,000 shares of common stock. 25% of the shares subject to the option would vest on August 25, 2024, and thereafter the balance would vest in equal monthly installments over the following 36 months, provided that, as an additional condition, no shares under the option would vest until the Issuer achieved a specific performance condition. On December 9, 2025, the Issuer's Board of Directors deemed that the performance condition had been met, resulting in vesting of the option as to 295,312 shares. The remainder of the unvested shares subject to the option shall vest monthly through August 25, 2027 subject to the continuous service of the Reporting Person through each such date.

F1 · derivative.expiration_date: On September 1, 2023, the Reporting Person was granted an option to purchase 525,000 shares of common stock. 25% of the shares subject to the option would vest on August 25, 2024, and thereafter the balance would vest in equal monthly installments over the following 36 months, provided that, as an additional condition, no shares under the option would vest until the Issuer achieved a specific performance condition. On December 9, 2025, the Issuer's Board of Directors deemed that the performance condition had been met, resulting in vesting of the option as to 295,312 shares. The remainder of the unvested shares subject to the option shall vest monthly through August 25, 2027 subject to the continuous service of the Reporting Person through each such date.

SEC source: 0001580787-25-000006 · form4-12112025_041203.xml · derivative · entry 1

Shah Pratik · CIK 0001580787 · Director · President, CEO and Chairperson

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 525,000

Underlying: Common Stock · 525,000 shares

Expires not disclosed

F1 · derivative.exercise_date: On September 1, 2023, the Reporting Person was granted an option to purchase 525,000 shares of common stock. 25% of the shares subject to the option would vest on August 25, 2024, and thereafter the balance would vest in equal monthly installments over the following 36 months, provided that, as an additional condition, no shares under the option would vest until the Issuer achieved a specific performance condition. On December 9, 2025, the Issuer's Board of Directors deemed that the performance condition had been met, resulting in vesting of the option as to 295,312 shares. The remainder of the unvested shares subject to the option shall vest monthly through August 25, 2027 subject to the continuous service of the Reporting Person through each such date.

F1 · derivative.expiration_date: On September 1, 2023, the Reporting Person was granted an option to purchase 525,000 shares of common stock. 25% of the shares subject to the option would vest on August 25, 2024, and thereafter the balance would vest in equal monthly installments over the following 36 months, provided that, as an additional condition, no shares under the option would vest until the Issuer achieved a specific performance condition. On December 9, 2025, the Issuer's Board of Directors deemed that the performance condition had been met, resulting in vesting of the option as to 295,312 shares. The remainder of the unvested shares subject to the option shall vest monthly through August 25, 2027 subject to the continuous service of the Reporting Person through each such date.

SEC source: 0001415889-25-024109 · form4-09102025_090913.xml · derivative · entry 2

Gover Justin D. · CIK 0001754129 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 15,833

Underlying: Common Stock · 15,833 shares

Expires 2035-09-08

F2 · derivative.exercise_date: The shares subject to the option will vest in equal monthly installments over 12 months following September 9, 2025.

SEC source: 0001415889-25-024109 · form4-09102025_090913.xml · derivative · entry 1

Gover Justin D. · CIK 0001754129 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 30,000

Underlying: Common Stock · 30,000 shares

Expires 2035-09-08

F1 · derivative.exercise_date: The shares subject to the option will vest in equal monthly installments over 36 months following September 9, 2025.

SEC source: 0001415889-25-021842 · form4-08142025_040805.xml · nonDerivative · entry 2

William Arsani · CIK 0001848372 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Logos Opportunities Fund II LP

Disclosed balance after: 1,000,000

F2 · ownership.nature: Logos Global Management LP is the investment advisor of private funds, including Logos Opportunities Fund II LP ("LOF II"). Logos Opportunities GP LLC ("GP I") is the general partner of LOF II. The Reporting Person is the Managing Member of GP I. The Reporting Person disclaims beneficial ownership of these securities except to the extent of Reporting Person's pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose.

SEC source: 0001415889-25-021842 · form4-08142025_040805.xml · nonDerivative · entry 1

William Arsani · CIK 0001848372 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Logos Global Master Fund LP

Disclosed balance after: 2,655,000

F1 · ownership.nature: Logos GP LLC ("Fund GP") is the general partner of Logos Global Master Fund LP (the "Fund"). The Reporting Person is the Managing Member of Fund GP. The Reporting Person disclaims beneficial ownership of these securities except to the extent of Reporting Person's pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose.

SEC source: 0000950170-25-085506 · ownership.xml · derivative · entry 1

George Simeon · CIK 0001595117 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,000

Underlying: Common Stock · 19,000 shares

Expires 2035-06-09

F1 · derivative.exercise_date: The shares subject to the option vest in equal monthly installments over 12 months following June 10, 2025 provided that the shares subject to the option will in any case be fully vested on the date of the Company's next annual meeting of stockholders.

SEC source: 0001415889-25-016957 · form4-06122025_040608.xml · derivative · entry 1

Prasad Deepa · CIK 0001867165 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,000

Underlying: Common Stock · 19,000 shares

Expires 2035-06-09

F1 · derivative.exercise_date: The shares subject to the option vest in equal monthly installments over 12 months following June 10, 2025 provided that the shares subject to the option will in any case be fully vested on the date of the Company's next annual meeting of stockholders.

SEC source: 0001415889-25-016959 · form4-06122025_040614.xml · derivative · entry 1

William Arsani · CIK 0001848372 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,000

Underlying: Common Stock · 19,000 shares

Expires 2035-06-09

F1 · derivative.exercise_date: The shares subject to the option vest in equal monthly installments over 12 months following June 10, 2025 provided that the shares subject to the option will in any case be fully vested on the date of the Company's next annual meeting of stockholders.

SEC source: 0001415889-25-016956 · form4-06122025_040606.xml · derivative · entry 1

Berger Heather A. · CIK 0001751873 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,000

Underlying: Common Stock · 19,000 shares

Expires 2035-06-09

F1 · derivative.exercise_date: The shares subject to the option vest in equal monthly installments over 12 months following June 10, 2025 provided that the shares subject to the option will in any case be fully vested on the date of the Company's next annual meeting of stockholders.

SEC source: 0001415889-25-016955 · form4-06122025_040604.xml · derivative · entry 1

LAPPE RODNEY W · CIK 0001579826 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,000

Underlying: Common Stock · 19,000 shares

Expires 2035-06-09

F1 · derivative.exercise_date: The shares subject to the option vest in equal monthly installments over 12 months following June 10, 2025 provided that the shares subject to the option will in any case be fully vested on the date of the Company's next annual meeting of stockholders.

SEC source: 0001415889-25-016958 · form4-06122025_040611.xml · derivative · entry 1

Schmid John P. · CIK 0001478916 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,000

Underlying: Common Stock · 19,000 shares

Expires 2035-06-09

F1 · derivative.exercise_date: The shares subject to the option vest in equal monthly installments over 12 months following June 10, 2025 provided that the shares subject to the option will in any case be fully vested on the date of the Company's next annual meeting of stockholders.

SEC source: 0001415889-25-014477 · form4-05232025_080531.xml · derivative · entry 1

Storgard Chris · CIK 0001674703 · Chief Medical Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 400,000

Underlying: Common Stock · 400,000 shares

Expires 2035-04-30

F1 · derivative.exercise_date: The shares subject to the option will vest as follows: 25% of the shares will vest on April 16, 2026 and the balance of the shares will vest in equal monthly installments thereafter over the following 36 months.

SEC source: 0001415889-25-000880 · form4-01062025_070132.xml · derivative · entry 1

LAPPE RODNEY W · CIK 0001579826 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 25,993

Underlying: Common Stock · 25,993 shares

Expires 2035-01-01

F1 · derivative.exercise_date: 25% of the shares subject to the option vest on January 1, 2026 and the balance will vest in equal monthly installments thereafter over a three year period.

SEC source: 0001415889-25-000879 · form4-01062025_070130.xml · derivative · entry 1

Burgess Julie · CIK 0001883722 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 135,000

Underlying: Common Stock · 135,000 shares

Expires 2035-01-01

F1 · derivative.exercise_date: The shares subject to the option will vest as follows: 20% of the shares will vest on January 1, 2026, 20% of the shares will vest in equal monthly installments over the following 12 months, 30% of the shares will vest in equal monthly installments over the following 12 months, and 30% of the shares will vest in equal monthly installments over the following 12 months.

SEC source: 0001415889-25-000877 · form4-01062025_070125.xml · derivative · entry 1

Jeffries Sean · CIK 0001848377 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 260,000

Underlying: Common Stock · 260,000 shares

Expires 2035-01-01

F1 · derivative.exercise_date: The shares subject to the option will vest as follows: 20% of the shares will vest on January 1, 2026, 20% of the shares will vest in equal monthly installments over the following 12 months, 30% of the shares will vest in equal monthly installments over the following 12 months, and 30% of the shares will vest in equal monthly installments over the following 12 months.

SEC source: 0001415889-25-000878 · form4-01062025_070127.xml · derivative · entry 1

Shah Pratik · CIK 0001580787 · Director · President, CEO and Chairperson

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 600,000

Underlying: Common Stock · 600,000 shares

Expires 2035-01-01

F1 · derivative.exercise_date: The shares subject to the option will vest as follows: 20% of the shares will vest on January 1, 2026, 20% of the shares will vest in equal monthly installments over the following 12 months, 30% of the shares will vest in equal monthly installments over the following 12 months, and 30% of the shares will vest in equal monthly installments over the following 12 months.

SEC source: 0001415889-24-029913 · form4-12192024_061201.xml · nonDerivative · entry 1

Prasad Deepa · CIK 0001867165 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 20,000

SEC source: 0001415889-24-021086 · form4-08122024_080818.xml · nonDerivative · entry 1

William Arsani · CIK 0001848372 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Logos SPV I LP

Disclosed balance after: 0

F1 · ownership.nature: Logos Global Management LP is the investment advisor of private funds, including Logos Opportunities Fund II LP ("LOF II") and Logos SPV 1 LP ("SPV 1"). Logos Opportunities GP LLC ("GP I") is the general partner of LOF II. Logos Opportunities II GP LLC ("GP II") is the general partner of SPV 1. The Reporting Person is the Managing Member of both GP I and GP II. The Reporting Person disclaims beneficial ownership of these securities except to the extent of Reporting Person's pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose.

SEC source: 0000950170-24-074363 · ownership.xml · derivative · entry 1

George Simeon · CIK 0001595117 · Director · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,000

Underlying: Common Stock · 19,000 shares

Expires 2034-06-12

F1 · derivative.exercise_date: The shares subject to the option vest in equal monthly installments over 12 months following June 13, 2024 provided that the shares subject to the option will in any case be fully vested on the date of the Company's next annual meeting of stockholders.

SEC source: 0001415889-24-017241 · form4-06172024_050620.xml · derivative · entry 1

William Arsani · CIK 0001848372 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,000

Underlying: Common Stock · 19,000 shares

Expires 2034-06-12

F1 · derivative.exercise_date: The shares subject to the option vest in equal monthly installments over 12 months following June 13, 2024 provided that the shares subject to the option will in any case be fully vested on the date of the Company's next annual meeting of stockholders.

SEC source: 0001415889-24-017239 · form4-06172024_050616.xml · derivative · entry 1

LAPPE RODNEY W · CIK 0001579826 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,000

Underlying: Common Stock · 19,000 shares

Expires 2034-06-12

F1 · derivative.exercise_date: The shares subject to the option vest in equal monthly installments over 12 months following June 13, 2024 provided that the shares subject to the option will in any case be fully vested on the date of the Company's next annual meeting of stockholders.

SEC source: 0001415889-24-017240 · form4-06172024_050618.xml · derivative · entry 1

Schmid John P. · CIK 0001478916 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,000

Underlying: Common Stock · 19,000 shares

Expires 2034-06-12

F1 · derivative.exercise_date: The shares subject to the option vest in equal monthly installments over 12 months following June 13, 2024 provided that the shares subject to the option will in any case be fully vested on the date of the Company's next annual meeting of stockholders.

SEC source: 0001415889-24-017238 · form4-06172024_050614.xml · derivative · entry 1

Berger Heather A. · CIK 0001751873 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,000

Underlying: Common Stock · 19,000 shares

Expires 2034-06-12

F1 · derivative.exercise_date: The shares subject to the option vest in equal monthly installments over 12 months following June 13, 2024 provided that the shares subject to the option will in any case be fully vested on the date of the Company's next annual meeting of stockholders.

SEC source: 0001415889-24-017237 · form4-06172024_050611.xml · derivative · entry 1

Prasad Deepa · CIK 0001867165 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 19,000

Underlying: Common Stock · 19,000 shares

Expires 2034-06-12

F1 · derivative.exercise_date: The shares subject to the option vest in equal monthly installments over 12 months following June 13, 2024 provided that the shares subject to the option will in any case be fully vested on the date of the Company's next annual meeting of stockholders.

SEC source: 0001415889-24-009063 · form4-03252024_110321.xml · nonDerivative · entry 3

Schmid John P. · CIK 0001478916 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Schmid Family Trust U/A dated 8-15-17

Disclosed balance after: 26,965

SEC source: 0001415889-24-009062 · form4-03252024_110307.xml · nonDerivative · entry 1

Berger Heather A. · CIK 0001751873 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,300

SEC source: 0001415889-24-009063 · form4-03252024_110321.xml · nonDerivative · entry 2

Schmid John P. · CIK 0001478916 · Director

10b5-1 filing: No plan indicated

Ownership: Indirect · By Schmid Family Trust U/A dated 8-15-17

Disclosed balance after: 9,156

F1 · price: The weighted average purchase price for the transaction reported was $3.6187, and the range of prices were between $3.43 and $3.72. Upon request by the SEC staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares sold at each separate price will be provided.

F2 · ownership.nature: The Reporting Person is trustee of the trust.

SEC source: 0001209191-24-001042 · doc4.xml · derivative · entry 1

Burgess Julie · CIK 0001883722 · Chief Accounting Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 110,000

Underlying: Common Stock · 110,000 shares

Expires 2034-01-01

F1 · derivative.exercise_date: The shares subject to the option will vest as follows: 20% of the shares will vest on January 1, 2025, 20% of the shares will vest in equal monthly installments over the following 12 months, 30% of the shares will vest in equal monthly installments over the following 12 months, and 30% of the shares will vest in equal monthly installments over the following 12 months.

SEC source: 0001209191-24-001039 · doc4.xml · derivative · entry 1

Jeffries Sean · CIK 0001848377 · Chief Operating Officer

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 350,000

Underlying: Common Stock · 350,000 shares

Expires 2034-01-01

F1 · derivative.exercise_date: The shares subject to the option will vest as follows: 20% of the shares will vest on January 1, 2025, 20% of the shares will vest in equal monthly installments over the following 12 months, 30% of the shares will vest in equal monthly installments over the following 12 months, and 30% of the shares will vest in equal monthly installments over the following 12 months.

SEC source: 0001209191-23-057548 · doc4.xml · derivative · entry 1

Ansari Aseem Z. · CIK 0001849177 · 10% owner

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2033-11-30

F1 · derivative.exercise_date: The shares subject to the option will vest as follows: 25% of the shares will vest on October 1, 2024 and the balance will vest in equal monthly installments thereafter over a three year period.

SEC source: 0001209191-23-057552 · doc4.xml · derivative · entry 1

LAPPE RODNEY W · CIK 0001579826 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 69,186

Underlying: Common Stock · 69,186 shares

Expires 2033-11-30

F1 · derivative.exercise_date: The shares subject to the option will vest as follows: 25% of the shares will vest on November 1, 2024 and the balance will vest in equal monthly installments thereafter over a three year period.

SEC source: 0001209191-23-051175 · doc4.xml · nonDerivative · entry 1

LAPPE RODNEY W · CIK 0001579826 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 133,024

F1 · price: The price reported in column 4 is a weighted average price. The shares were purchased at a range of prices between $2.33 and $2.38. Upon request by the Securities and Exchange Commission staff, the Issuer, or any security holder of the Issuer, full information regarding the number of shares purchased at each separate price will be provided.

SEC source: 0001209191-23-048222 · doc4.xml · derivative · entry 3

Shah Pratik · CIK 0001580787 · Director · President, CEO and Chairperson

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 525,000

Underlying: Common Stock · 525,000 shares

Expires 2033-08-31

F3 · derivative.exercise_date: The shares subject to the option will vest as follows provided that the Company initiates a Phase 2a clinical trial for a product candidate for the treatment of FA: 25% of the shares subject to the option will vest one year following August 25, 2023, and thereafter the balance of the shares will vest in equal monthly installments over the following 36 months.

SEC source: 0001209191-23-048222 · doc4.xml · derivative · entry 2

Shah Pratik · CIK 0001580787 · Director · President, CEO and Chairperson

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 525,000

Underlying: Common Stock · 525,000 shares

Expires 2033-08-31

F2 · derivative.exercise_date: The shares subject to the option will vest as follows provided that an investigational new drug application for a product candidate for the treatment of Friedrich ataxia ("FA") submitted by the Issuer after September 1, 2023 receives clearance from the U.S. Food and Drug Administration: 25% of the shares subject to the option will vest one year following August 25, 2023, and thereafter the balance of the shares will vest in equal monthly installments over the following 36 months.

SEC source: 0001209191-23-048222 · doc4.xml · derivative · entry 1

Shah Pratik · CIK 0001580787 · Director · President, CEO and Chairperson

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 1,050,000

Underlying: Common Stock · 1,050,000 shares

Expires 2033-08-31

F1 · derivative.exercise_date: The shares subject to the option will vest as follows: 25% of the shares subject to the option will vest one year following August 25, 2023, and thereafter the balance of the shares will vest in equal monthly installments over the following 36 months.

SEC source: 0001209191-23-047774 · doc4.xml · nonDerivative · entry 1

Prasad Deepa · CIK 0001867165 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 23,806

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.29 to $2.31, inclusive. The Reporting Person undertakes to provide the Issuer, and security holder of the Issuer, or the staff at the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each price within the range set forth herein.