CYCN

SEC source: 0001140361-21-022575 · form4.xml · derivative · entry 1

Isacson Ole · CIK 0001772001 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2031-06-24

F1 · derivative.exercise_date: . The options, granted pursuant to the director compensation plan, will vest in full on the first anniversary of the grant date

SEC source: 0001140361-21-022569 · form4.xml · derivative · entry 1

Churchwell Kevin · CIK 0001771984 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2031-06-24

F1 · derivative.exercise_date: The options, granted pursuant to the director compensation plan, will vest in full on the first anniversary of the grant date.

SEC source: 0000899243-21-022327 · doc4.xml · nonDerivative · entry 2

MCGUIRE TERRANCE · CIK 0001117003 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Polaris Entrepreneurs' Fund VIII, L.P.

Disclosed balance after: 24,957

F1 · shares: On June 3, 2021, Polaris Partners VIII, L.P. ("PP VIII") and Polaris Entrepreneurs' Fund VIII, L.P. ("PEF VIII") agreed to purchase directly from the Issuer such shares of Common Stock of the Issuer in a private placement transaction.

F3 · ownership.nature: The reportable securities are owned directly by PEF VIII. PPGP VIII is the general partner of PEF VIII. The Reporting Person, a member of the Issuer's Board of Directors, is an interest holder of PPGP VIII. Each of the Reporting Person and the Managing Members, in their respective capacities with respect to PPGP VIII, may be deemed to have shared voting and dispositive power over the shares held by PEF VIII. Each of PPGP VIII, the Reporting Person and the Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0000899243-21-022327 · doc4.xml · nonDerivative · entry 1

MCGUIRE TERRANCE · CIK 0001117003 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Polaris Partners VIII, L.P.

Disclosed balance after: 697,313

F1 · shares: On June 3, 2021, Polaris Partners VIII, L.P. ("PP VIII") and Polaris Entrepreneurs' Fund VIII, L.P. ("PEF VIII") agreed to purchase directly from the Issuer such shares of Common Stock of the Issuer in a private placement transaction.

F2 · ownership.nature: The reportable securities are owned directly by PP VIII. Polaris Partners GP VIII, L.L.C. ("PPGP VIII") is the general partner of PP VIII. The Reporting Person, a member of the Issuer's Board of Directors, is an interest holder of PPGP VIII. Each of David Barrett, Brian Chee, Amir Nashat and Bryce Youngren are the managing members of PPGP VIII (collectively, the "Managing Members"). Each of the Reporting Person and the Managing Members, in their respective capacities with respect to PPGP VIII, may be deemed to have shared voting and dispositive power over the shares held by PP VIII. Each of PPGP VIII, the Reporting Person and the Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0001140361-21-020090 · form4.xml · nonDerivative · entry 1

Hecht Peter M · CIK 0001478485 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,047,698

F1 · shares: On June 3, 2021, the reporting person agreed to purchase directly from the Issuer 823,170 shares of Common Stock of the Issuer in a private placement transaction.

SEC source: 0000902664-21-003032 · ownership.xml · nonDerivative · entry 1

Slate Path Capital LP · CIK 0001559706 · 10% owner

Greenspan David Gerald · CIK 0001820641 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 7,157,601

F1 · ownership.nature: The securities to which this filing relates are held by Slate Path Master Fund LP (the "Master Fund"), a Cayman Islands exempted limited partnership. Slate Path Capital LP (the "Investment Manager"), a Delaware limited partnership acts as the investment manager of the Master Fund. Mr. David Greenspan serves as the managing member of Jades GP, LLC, a Delaware limited liability company and the general partner of the Investment Manager. The filing of this statement shall not be deemed an admission that either Reporting Person is the beneficial owner of the securities reported herein for purposes of Section 16 of the Securities Act of 1934, as amended, or otherwise. Each of the Reporting Persons expressly disclaims beneficial ownership of the securities reported herein except to the extent of its pecuniary interest therein.

SEC source: 0001140361-21-016532 · form4.xml · nonDerivative · entry 1

Hecht Peter M · CIK 0001478485 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,224,528

F1 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.31 to $2.59, inclusive. The reporting person will provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each price within the range set forth in this footnote.

SEC source: 0001140361-21-016304 · form4.xml · nonDerivative · entry 2

Hecht Peter M · CIK 0001478485 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 922,528

F2 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.32 to $2.61, inclusive. The reporting person will provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each price within the range set forth in this footnote.

SEC source: 0001140361-21-016304 · form4.xml · nonDerivative · entry 1

Hecht Peter M · CIK 0001478485 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 524,527

F1 · price: The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.10 to $2.45, inclusive. The reporting person will provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each price within the range set forth in this footnote.

SEC source: 0001140361-21-006649 · form4.xml · nonDerivative · entry 1

Gjino Anjeza · CIK 0001839068 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 31,599

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. This sale was made to cover tax withholding obligations in connection with the vesting and settlement of approximately 25% of the reporting person's restricted stock units granted on April 1, 2019.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.80 to $4.00, inclusive. The reporting person will provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each price within the range set forth in this footnote.

SEC source: 0001140361-21-006641 · form4.xml · nonDerivative · entry 1

Wright Christopher I · CIK 0001838503 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,728

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. This sale was made to cover tax withholding obligations in connection with the vesting and settlement of approximately 25% of the reporting person's restricted stock units granted on April 1, 2019.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $3.80 to $4.00, inclusive. The reporting person will provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each price within the range set forth in this footnote.

SEC source: 0001140361-20-029869 · form4.xml · nonDerivative · entry 1

Currie Mark G · CIK 0001478244 · President and CSO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 251,648

F1 · shares: The proceeds from the sale are intended to cover income taxes arising out of prior stock option exercises, including those in which the reporting person held the underlying shares.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $2.94 to $3.07, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-20-058031 · doc4.xml · nonDerivative · entry 1

Busch Andreas · CIK 0001775029 · Chief Innovation Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 254,704

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $2.48 to $2.60, inclusive. The reporting person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, full information regarding the number of shares purchased at each price within the range.

F2 · balance_after: The reporting person acquired 2,204 and 2,500 shares of Common Stock under the issuer's employee stock purchase plan on November 29, 2019 and May 29, 2020, respectively.

SEC source: 0001209191-20-057768 · doc4.xml · nonDerivative · entry 1

Huyett William · CIK 0001723846 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 67,590

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. This sale was made to cover tax withholding obligations in connection with the vesting and settlement of approximately 25% of the reporting person's restricted stock units granted on April 1, 2019.

SEC source: 0001209191-20-057302 · doc4.xml · derivative · entry 1

Busch Andreas · CIK 0001775029 · Chief Innovation Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2030-11-04

F1 · derivative.exercise_date: The Option vests as to 2.08333% of the shares of Common Stock on each monthly anniversary of November 4, 2020.

SEC source: 0001209191-20-037587 · doc4.xml · derivative · entry 1

CONRADES GEORGE H · CIK 0001106231 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2030-06-16

F1 · derivative.exercise_date: The options, granted pursuant to the director compensation plan, will vest in full on the first anniversary of the grant date.

SEC source: 0001209191-20-037571 · doc4.xml · derivative · entry 1

MCGUIRE TERRANCE · CIK 0001117003 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2030-06-16

F1 · derivative.exercise_date: The options, granted pursuant to the director compensation plan, will vest in full on the first anniversary of the grant date.

SEC source: 0001209191-20-037566 · doc4.xml · derivative · entry 1

SCHULMAN AMY W · CIK 0001438226 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2030-06-16

F1 · derivative.exercise_date: The options, granted pursuant to the director compensation plan, will vest in full on the first anniversary of the grant date.

SEC source: 0001209191-20-037580 · doc4.xml · derivative · entry 1

Fanucci Marsha · CIK 0001298814 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2030-06-16

F1 · derivative.exercise_date: The options, granted pursuant to the director compensation plan, will vest in full on the first anniversary of the grant date.

SEC source: 0001209191-20-037568 · doc4.xml · derivative · entry 1

Mendelsohn Michael · CIK 0001591109 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2030-06-16

F1 · derivative.exercise_date: The options, granted pursuant to the director compensation plan, will vest in full on the first anniversary of the grant date.

SEC source: 0001209191-20-037589 · doc4.xml · derivative · entry 1

Churchwell Kevin · CIK 0001771984 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2030-06-16

F1 · derivative.exercise_date: The options, granted pursuant to the director compensation plan, will vest in full on the first anniversary of the grant date.

SEC source: 0001209191-20-037575 · doc4.xml · derivative · entry 1

Isacson Ole · CIK 0001772001 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2030-06-16

F1 · derivative.exercise_date: The options, granted pursuant to the director compensation plan, will vest in full on the first anniversary of the grant date.

SEC source: 0001209191-20-037573 · doc4.xml · derivative · entry 1

Lovell Stephanie · CIK 0001772054 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2030-06-16

F1 · derivative.exercise_date: The options, granted pursuant to the director compensation plan, will vest in full on the first anniversary of the grant date.

SEC source: 0001209191-20-022657 · doc4.xml · derivative · entry 5

Hecht Peter M · CIK 0001478485 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 153,846

Underlying: Common Stock · 153,846 shares

Expires 2030-03-31

F3 · shares: The Compensation Committee approved the stock option award to the reporting person in order to offset his low-to-market total cash compensation and provide him with a market-aligned total compensation package for 2019, 2020, and 2021. 36,436 options under the award are intended to offset his below-market total cash salary for 2019, and 58,705 options under the award are intended to offset his below-market total cash compensation for each of 2020 and 2021.

F4 · derivative.exercise_date: The options, granted as an annual performance award, vests in seventy-two equal monthly installments over a six year period on each monthly anniversary of January 1, 2020 until fully vested.

SEC source: 0001209191-20-012430 · doc4.xml · nonDerivative · entry 1

Huyett William · CIK 0001723846 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 71,417

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. This sale was made to cover tax withholding obligations in connection with the vesting and settlement of approximately 25% of the reporting person's restricted stock units granted on April 1, 2019.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $5.12 to $5.25, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-19-062322 · doc4.xml · nonDerivative · entry 2

Currie Mark G · CIK 0001478244 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 271,755

F1 · shares: The proceeds from the sale are intended to cover income taxes arising out of prior stock option exercises, including those in which the reporting person held the underlying shares.

F3 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $2.38 to $2.60, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-19-062322 · doc4.xml · nonDerivative · entry 1

Currie Mark G · CIK 0001478244 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 296,755

F1 · shares: The proceeds from the sale are intended to cover income taxes arising out of prior stock option exercises, including those in which the reporting person held the underlying shares.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $2.54 to $2.58, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-19-058165 · doc4.xml · derivative · entry 1

Hecht Peter M · CIK 0001478485 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2029-11-22

F1 · derivative.exercise_date: The stock option grant will vest and become exercisable upon the attainment of both performance-based and service-based hurdles, as follows: (i) 20% of the shares subject to the option, if the average closing price of the common stock reported by Nasdaq for any thirty (30) consecutive trading days equals or exceeds $10; plus an additional (ii) 40% of the shares, if the average closing price equals or exceeds $20; plus an additional (iii) 40% of the shares, if the average closing price equals or exceeds $30; in each case, subject to the continuous employment or service through the later of the date that the performance hurdles set forth above are attained (but no later than December 31, 2024) and December 31, 2021.

F2 · derivative.expiration_date: To the extent unvested as of December 31, 2024, all unvested shares underlying such performance-based option will be cancelled.

SEC source: 0001209191-19-058163 · doc4.xml · derivative · entry 1

Currie Mark G · CIK 0001478244 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2029-11-22

F1 · derivative.exercise_date: The stock option grant will vest and become exercisable upon the attainment of both performance-based and service-based hurdles, as follows: (i) 20% of the shares subject to the option, if the average closing price of the common stock reported by Nasdaq for any thirty (30) consecutive trading days equals or exceeds $10; plus an additional (ii) 40% of the shares, if the average closing price equals or exceeds $20; plus an additional (iii) 40% of the shares, if the average closing price equals or exceeds $30; in each case, subject to the continuous employment or service through the later of the date that the performance hurdles set forth above are attained (but no later than December 31, 2024) and December 31, 2021.

F2 · derivative.expiration_date: To the extent unvested as of December 31, 2024, all unvested shares underlying such performance-based option will be cancelled.

SEC source: 0001209191-19-058162 · doc4.xml · derivative · entry 1

Huyett William · CIK 0001723846 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2029-11-22

F1 · derivative.exercise_date: The stock option grant will vest and become exercisable upon the attainment of both performance-based and service-based hurdles, as follows: (i) 20% of the shares subject to the option, if the average closing price of the common stock reported by Nasdaq for any thirty (30) consecutive trading days equals or exceeds $10; plus an additional (ii) 40% of the shares, if the average closing price equals or exceeds $20; plus an additional (iii) 40% of the shares, if the average closing price equals or exceeds $30; in each case, subject to the continuous employment or service through the later of the date that the performance hurdles set forth above are attained (but no later than December 31, 2024) and December 31, 2021.

F2 · derivative.expiration_date: To the extent unvested as of December 31, 2024, all unvested shares underlying such performance-based option will be cancelled.

SEC source: 0001209191-19-058158 · doc4.xml · derivative · entry 1

Busch Andreas · CIK 0001775029 · Chief Innovation Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2029-11-22

F1 · derivative.exercise_date: The stock option grant will vest and become exercisable upon the attainment of both performance-based and service-based hurdles, as follows: (i) 20% of the shares subject to the option, if the average closing price of the common stock reported by Nasdaq for any thirty (30) consecutive trading days equals or exceeds $10; plus an additional (ii) 40% of the shares, if the average closing price equals or exceeds $20; plus an additional (iii) 40% of the shares, if the average closing price equals or exceeds $30; in each case, subject to the continuous employment or service through the later of the date that the performance hurdles set forth above are attained (but no later than December 31, 2024) and December 31, 2021.

F2 · derivative.expiration_date: To the extent unvested as of December 31, 2024, all unvested shares underlying such performance-based option will be cancelled.

SEC source: 0001209191-19-057112 · doc4.xml · nonDerivative · entry 1

Busch Andreas · CIK 0001775029 · Chief Innovation Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 125,000

F1 · price: The price reported in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $1.79 to $1.87, inclusive. The reporting person will provide to the Issuer, any security holder of the Issuer or the SEC staff, upon request, full information regarding the number of shares purchased at each price within the range.

SEC source: 0001209191-19-056008 · doc4.xml · nonDerivative · entry 1

Huyett William · CIK 0001723846 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 74,976

F1 · shares: This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. This sale was made to cover tax withholding obligations in connection with the vesting and settlement of approximately 25% of the reporting person's restricted stock units granted on April 1, 2019.

F2 · price: The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $2.05 to $2.0675, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.

SEC source: 0001209191-19-041920 · doc4.xml · derivative · entry 5

Hecht Peter M · CIK 0001478485 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,000 shares

Expires 2019-07-28

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: This option to purchase 20,167 shares vests in installments upon achievement of certain regulatory and commercial milestones. The option has vested as to 2,000 shares as of the date hereof.

SEC source: 0001209191-19-041920 · doc4.xml · nonDerivative · entry 1

Hecht Peter M · CIK 0001478485 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 225,192

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · shares: This transaction represents the acquisition of common stock as a result of the exercise and hold of derivative securities reported in Table II.

SEC source: 0001209191-19-034371 · doc4.xml · derivative · entry 1

CONRADES GEORGE H · CIK 0001106231 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2029-06-01

F1 · derivative.exercise_date: The options, granted pursuant to the director compensation plan, will vest in full on the first anniversary of the grant date.

SEC source: 0001209191-19-034379 · doc4.xml · derivative · entry 1

MCGUIRE TERRANCE · CIK 0001117003 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2029-06-01

F1 · derivative.exercise_date: The options, granted pursuant to the director compensation plan, will vest in full on the first anniversary of the grant date.

SEC source: 0001209191-19-034383 · doc4.xml · derivative · entry 1

SCHULMAN AMY W · CIK 0001438226 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2029-06-01

F1 · derivative.exercise_date: The options, granted pursuant to the director compensation plan, will vest in full on the first anniversary of the grant date.

SEC source: 0001209191-19-034373 · doc4.xml · derivative · entry 1

Fanucci Marsha · CIK 0001298814 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2029-06-01

F1 · derivative.exercise_date: The options, granted pursuant to the director compensation plan, will vest in full on the first anniversary of the grant date.

SEC source: 0001209191-19-034382 · doc4.xml · derivative · entry 1

Mendelsohn Michael · CIK 0001591109 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2029-06-01

F1 · derivative.exercise_date: The options, granted pursuant to the director compensation plan, will vest in full on the first anniversary of the grant date.

SEC source: 0001209191-19-034376 · doc4.xml · derivative · entry 1

Lovell Stephanie · CIK 0001772054 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2029-06-01

F1 · derivative.exercise_date: The options, granted pursuant to the director compensation plan, will vest in full on the first anniversary of the grant date.

SEC source: 0001209191-19-034375 · doc4.xml · derivative · entry 1

Isacson Ole · CIK 0001772001 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2029-06-01

F1 · derivative.exercise_date: The options, granted pursuant to the director compensation plan, will vest in full on the first anniversary of the grant date.

SEC source: 0001209191-19-034369 · doc4.xml · derivative · entry 1

Churchwell Kevin · CIK 0001771984 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2029-06-01

F1 · derivative.exercise_date: The options, granted pursuant to the director compensation plan, will vest in full on the first anniversary of the grant date.

SEC source: 0001209191-19-026820 · doc4.xml · derivative · entry 1

Busch Andreas · CIK 0001775029 · Chief Innovation Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 300,000

Underlying: Common Stock · 300,000 shares

Expires 2029-04-29

F1 · derivative.exercise_date: The option, granted as a new hire award, vests as to 25% of the shares of Common Stock on the first anniversary of April 29, 2019 and 1/48th of the shares of Common Stock vest each month thereafter for the next 36 months, based on his continued employment by a subsidiary of the Issuer.

SEC source: 0001209191-19-024237 · doc4.xml · nonDerivative · entry 2

MCGUIRE TERRANCE · CIK 0001117003 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Polaris Entrepreneurs' Fund VIII, L.P.

Disclosed balance after: 21,635

F1 · shares: These shares were acquired from unaffiliated stockholders in a negotiated, private transaction.

F3 · ownership.nature: The reportable securities are owned directly by Polaris Entrepreneurs' Fund VIII, L.P. ("PEF VIII"). PPGP VIII is the general partner of PEF VIII. The Reporting Person, a member of the Issuer's Board of Directors, is an interest holder of PPGP VIII. Each of the Reporting Person and the Managing Members, in their respective capacities with respect to PPGP VIII, may be deemed to have shared voting and dispositive power over the shares held by PEF VIII. Each of PPGP VIII, the Reporting Person and the Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0001209191-19-024237 · doc4.xml · nonDerivative · entry 1

MCGUIRE TERRANCE · CIK 0001117003 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Polaris Partners VIII, L.P.

Disclosed balance after: 604,482

F1 · shares: These shares were acquired from unaffiliated stockholders in a negotiated, private transaction.

F2 · ownership.nature: The reportable securities are owned directly by Polaris Partners VIII, L.P. ("PP VIII"). Polaris Partners GP VIII, L.L.C. ("PPGP VIII") is the general partner of PP VIII. The Reporting Person, a member of the Issuer's Board of Directors, is an interest holder of PPGP VIII. Each of David Barrett, Brian Chee, Amir Nashat and Bryce Youngren are the managing members of PPGP VIII (collectively, the "Managing Members"). Each of the Reporting Person and the Managing Members, in their respective capacities with respect to PPGP VIII, may be deemed to have shared voting and dispositive power over the shares held by PP VIII. Each of PPGP VIII, the Reporting Person and the Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0001209191-19-024236 · doc4.xml · nonDerivative · entry 2

SCHULMAN AMY W · CIK 0001438226 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Polaris Entrepreneurs' Fund VIII, L.P.

Disclosed balance after: 21,635

F1 · shares: These shares were acquired from unaffiliated stockholders in a negotiated, private transaction.

F3 · ownership.nature: The reportable securities are owned directly by Polaris Entrepreneurs' Fund VIII, L.P. ("PEF VIII"). PPGP VIII is the general partner of PEF VIII. The Reporting Person, a member of the Issuer's Board of Directors, is an interest holder of PPGP VIII. Each of the Reporting Person and the Managing Members, in their respective capacities with respect to PPGP VIII, may be deemed to have shared voting and dispositive power over the shares held by PEF VIII. Each of PPGP VIII, the Reporting Person and the Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0001209191-19-024236 · doc4.xml · nonDerivative · entry 1

SCHULMAN AMY W · CIK 0001438226 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Polaris Partners VIII, L.P.

Disclosed balance after: 604,482

F1 · shares: These shares were acquired from unaffiliated stockholders in a negotiated, private transaction.

F2 · ownership.nature: The reportable securities are owned directly by Polaris Partners VIII, L.P. ("PP VIII"). Polaris Partners GP VIII, L.L.C. ("PPGP VIII") is the general partner of PP VIII. The Reporting Person, a member of the Issuer's Board of Directors, is an interest holder of PPGP VIII. Each of David Barrett, Brian Chee, Amir Nashat and Bryce Youngren are the managing members of PPGP VIII (collectively, the "Managing Members"). Each of the Reporting Person and the Managing Members, in their respective capacities with respect to PPGP VIII, may be deemed to have shared voting and dispositive power over the shares held by PP VIII. Each of PPGP VIII, the Reporting Person and the Managing Members disclaims beneficial ownership of these securities and this report shall not be deemed an admission that any one of them is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of their respective pecuniary interests therein.

SEC source: 0001209191-19-023521 · doc4.xml · nonDerivative · entry 2

Currie Mark G · CIK 0001478244 · President

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 321,755

SEC source: 0001104659-19-019466 · a4.xml · nonDerivative · entry 2

IRONWOOD PHARMACEUTICALS INC · CIK 0001446847 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F2 · kind: Ironwood distributed all of the issued and outstanding shares of Cyclerion common stock to its stockholders on a pro rata basis as part of the separation of Cyclerion from Ironwood into two independent public companies.