CRVO

SEC source: 0001437749-21-005060 · rdgdoc.xml · derivative · entry 2

Cobuzzi Robert Joseph Jr. · CIK 0001799838 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 161,139

Underlying: Common Stock · 161,139 shares

Expires 2031-03-01

F2 · derivative.exercise_date: The amount reported reflects the maximum number of shares of common stock underlying the award that may vest based upon the achievement of specified performance metrics. The vesting of such shares is contingent upon the timely and successful achievement during the year ending December 31, 2021 of certain performance milestones related to the Issuer's planned clinical trials, with the vesting of one-third (1/3) of the total shares tied to each such milestone. If any such milestone is achieved, one-third (1/3) of the shares tied to such milestone (i.e. one-ninth (1/9) of the total shares underlying the award) will vest immediately and the remainder of the shares tied to such milestone (i.e. two-ninths (2/9) of the total shares underlying the award) will vest in 24 equal (or as near equal as possible) monthly installments on the last calendar day of each month over a 24-month period commencing January 31, 2022. In order for all shares underlying the award to vest, all three milestones mus

SEC source: 0001437749-21-005060 · rdgdoc.xml · derivative · entry 1

Cobuzzi Robert Joseph Jr. · CIK 0001799838 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 53,713

Underlying: Common Stock · 53,713 shares

Expires 2031-03-01

F1 · derivative.exercise_date: The shares of common stock underlying the award will vest in 36 equal (or as near equal as possible) monthly installments on the last calendar day of each month over a 36-month period commencing March 31, 2021.

SEC source: 0001437749-21-005059 · rdgdoc.xml · derivative · entry 2

ELDER WILLIAM ROBERT · CIK 0001828068 · GC & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 62,522

Underlying: Common Stock · 62,522 shares

Expires 2031-03-01

F2 · derivative.exercise_date: The amount reported reflects the maximum number of shares of common stock underlying the award that may vest based upon the achievement of specified performance metrics. The vesting of such shares is contingent upon the timely and successful achievement during the year ending December 31, 2021 of certain performance milestones related to the Issuer's planned clinical trials, with the vesting of one-third (1/3) of the total shares tied to each such milestone. If any such milestone is achieved, one-third (1/3) of the shares tied to such milestone (i.e. one-ninth (1/9) of the total shares underlying the award) will vest immediately and the remainder of the shares tied to such milestone (i.e. two-ninths (2/9) of the total shares underlying the award) will vest in 24 equal (or as near equal as possible) monthly installments on the last calendar day of each month over a 24-month period commencing January 31, 2022. In order for all shares underlying the award to vest, all three milestones mus

SEC source: 0001437749-21-005059 · rdgdoc.xml · derivative · entry 1

ELDER WILLIAM ROBERT · CIK 0001828068 · GC & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 87,684

Underlying: Common Stock · 87,684 shares

Expires 2031-03-01

F1 · derivative.exercise_date: The shares of common stock underlying the award will vest in 36 equal (or as near equal as possible) monthly installments on the last calendar day of each month over a 36-month period commencing March 31, 2021.

SEC source: 0001437749-21-005058 · rdgdoc.xml · derivative · entry 2

GALLOWAY CHRISTOPHER D · CIK 0001829319 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 81,537

Underlying: Common Stock · 81,537 shares

Expires 2031-03-01

F2 · derivative.exercise_date: The amount reported reflects the maximum number of shares of common stock underlying the award that may vest based upon the achievement of specified performance metrics. The vesting of such shares is contingent upon the timely and successful achievement during the year ending December 31, 2021 of certain performance milestones related to the Issuer's planned clinical trials, with the vesting of one-third (1/3) of the total shares tied to each such milestone. If any such milestone is achieved, one-third (1/3) of the shares tied to such milestone (i.e. one-ninth (1/9) of the total shares underlying the award) will vest immediately and the remainder of the shares tied to such milestone (i.e. two-ninths (2/9) of the total shares underlying the award) will vest in 24 equal (or as near equal as possible) monthly installments on the last calendar day of each month over a 24-month period commencing January 31, 2022. In order for all shares underlying the award to vest, all three milestones mus

SEC source: 0001437749-21-005058 · rdgdoc.xml · derivative · entry 1

GALLOWAY CHRISTOPHER D · CIK 0001829319 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,180

Underlying: Common Stock · 27,180 shares

Expires 2031-03-01

F1 · derivative.exercise_date: The shares of common stock underlying the award will vest in 36 equal (or as near equal as possible) monthly installments on the last calendar day of each month over a 36-month period commencing March 31, 2021.

SEC source: 0001437749-21-005057 · rdgdoc.xml · derivative · entry 2

Hornung William Karl · CIK 0001612066 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,069

Underlying: Common Stock · 80,069 shares

Expires 2031-03-01

F2 · derivative.exercise_date: The amount reported reflects the maximum number of shares of common stock underlying the award that may vest based upon the achievement of specified performance metrics. The vesting of such shares is contingent upon the timely and successful achievement during the year ending December 31, 2021 of certain performance milestones related to the Issuer's planned clinical trials, with the vesting of one-third (1/3) of the total shares tied to each such milestone. If any such milestone is achieved, one-third (1/3) of the shares tied to such milestone (i.e. one-ninth (1/9) of the total shares underlying the award) will vest immediately and the remainder of the shares tied to such milestone (i.e. two-ninths (2/9) of the total shares underlying the award) will vest in 24 equal (or as near equal as possible) monthly installments on the last calendar day of each month over a 24-month period commencing January 31, 2022. In order for all shares underlying the award to vest, all three milestones mus

SEC source: 0001437749-21-005057 · rdgdoc.xml · derivative · entry 1

Hornung William Karl · CIK 0001612066 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 122,771

Underlying: Common Stock · 122,771 shares

Expires 2031-03-01

F1 · derivative.exercise_date: The shares of common stock underlying the award will vest in 36 equal (or as near equal as possible) monthly installments on the last calendar day of each month over a 36-month period commencing March 31, 2021.

SEC source: 0001437749-20-024126 · rdgdoc.xml · nonDerivative · entry 2

ELDER WILLIAM ROBERT · CIK 0001828068 · GC & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 15,000

F2 · price: The price reported is a weighted average price. The shares were purchased in multiple open-market transactions at prices ranging from $0.6234 to $0.6298, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full detail regarding the number of shares sold at each separate price within such range.

SEC source: 0001437749-20-024187 · rdgdoc.xml · nonDerivative · entry 1

Cobuzzi Robert Joseph Jr. · CIK 0001799838 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,000

SEC source: 0001437749-20-024126 · rdgdoc.xml · nonDerivative · entry 1

ELDER WILLIAM ROBERT · CIK 0001828068 · GC & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

F1 · price: The price reported is a weighted average price. The shares were purchased in multiple open-market transactions at prices ranging from $0.6492 to $0.6890, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full detail regarding the number of shares sold at each separate price within such range.

SEC source: 0001437749-20-021435 · rdgdoc.xml · derivative · entry 1

GALLOWAY CHRISTOPHER D · CIK 0001829319 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 200,000

Underlying: Common Stock · 200,000 shares

Expires 2030-10-19

F1 · security: In connection with the Reporting Person's new employment with the Issuer, the Compensation Committee of the Issuer's Board of Directors approved the grant of non-qualified stock options to the Reporting Person. The grant was made as an inducement material to the Reporting Person's acceptance of employment with the Issuer, in accordance with NASDAQ Listing Rule 5635(c)(4).

F2 · derivative.exercise_date: The shares underlying the options will vest in 36 equal (or as nearly equal as possible) monthly installments on the last calendar day of each month over a 36-month period beginning November 30, 2020.

SEC source: 0001437749-20-021143 · rdgdoc.xml · derivative · entry 1

ELDER WILLIAM ROBERT · CIK 0001828068 · GC & Secretary

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 70,000

Underlying: Common Stock · 70,000 shares

Expires 2030-09-22

F1 · security: In connection with the Reporting Person's new employment with the Issuer, the Compensation Committee of the Issuer's Board of Directors approved the grant of non-qualified stock options to the Reporting Person. The grant was made as an inducement material to the Reporting Person's acceptance of employment with the Issuer, in accordance with NASDAQ Listing Rule 5635(c)(4).

F2 · derivative.exercise_date: The shares underlying the options will vest in 36 equal (or as nearly equal as possible) monthly installments on the last calendar day of each month over a 36-month period beginning October 31, 2020.

SEC source: 0001437749-20-019648 · rdgdoc.xml · derivative · entry 1

Cobuzzi Robert Joseph Jr. · CIK 0001799838 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 475,000

Underlying: Common Stock · 475,000 shares

Expires 2030-09-08

F1 · derivative.exercise_date: On September 8, 2020, the Reporting person was granted an option to purchase 475,000 shares of the Company's common stock; provided, however, that the Reporting Person's continued holding of the grant is contingent upon the annual automatic increase in the share pool under the Issuer's 2015 Equity Incentive Plan on January 1, 2021 being sufficient to cover all shares of the Issuer's common stock underlying the grant. Subject to the foregoing, one-twelfth of the option grant will vest on January 1, 2021, and thereafter the grant will vest monthly in substantially equal 1/36th increments on the last day of each month, beginning on January 31, 2021 through the last day of the month containing the third anniversary of the grant date, subject to the Reporting Person's continued employment with the Company through the applicable vesting date.

SEC source: 0001437749-20-020635 · rdgdoc.xml · derivative · entry 2

Hollingsworth Jane H · CIK 0001297141 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 54,900

Underlying: Common Stock · 54,900 shares

Expires not disclosed

F2 · derivative.exercise_price: 2. Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: 3. The shares underlying the restricted stock units will vest in 6 equal (or as nearly equal as possible) quarterly installments on the last calendar day of each quarter over an 18-month period beginning on March 1, 2022.

F3 · derivative.expiration_date: 3. The shares underlying the restricted stock units will vest in 6 equal (or as nearly equal as possible) quarterly installments on the last calendar day of each quarter over an 18-month period beginning on March 1, 2022.

SEC source: 0001437749-20-020635 · rdgdoc.xml · derivative · entry 1

Hollingsworth Jane H · CIK 0001297141 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 67,400

Underlying: Common Stock · 67,400 shares

Expires 2030-09-01

F1 · derivative.exercise_date: 1. The shares underlying the options will vest in 18 equal (or as nearly equal as possible) monthly installments on the last calendar day of each month over an 18-month period beginning September 30, 2020.

SEC source: 0001437749-20-013423 · rdgdoc.xml · derivative · entry 1

Adams Robert W · CIK 0001663144 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 61,300

Underlying: Common Stock · 61,300 shares

Expires 2030-06-17

F1 · derivative.exercise_date: The shares underlying the options vest in 12 equal (or as nearly equal as possible) monthly installments on the last calendar day of each month over a one-year period beginning on June 17, 2020.

SEC source: 0001437749-20-013421 · rdgdoc.xml · derivative · entry 1

Giles Mark T · CIK 0001663219 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 61,300

Underlying: Common Stock · 61,300 shares

Expires 2030-06-17

F1 · derivative.exercise_date: The shares underlying the options vest in 12 equal (or as nearly equal as possible) monthly installments on the last calendar day of each month over a one-year period beginning on June 17, 2020.

SEC source: 0001437749-20-013422 · rdgdoc.xml · derivative · entry 1

Cobuzzi Robert Joseph Jr. · CIK 0001799838 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 61,300

Underlying: Common Stock · 61,300 shares

Expires 2030-06-17

F1 · derivative.exercise_date: The shares underlying the options vest in 12 equal (or as nearly equal as possible) monthly installments on the last calendar day of each month over a one-year period beginning on June 17, 2020.

SEC source: 0001437749-20-013420 · rdgdoc.xml · derivative · entry 1

LEVIN ALAN G · CIK 0001174452 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 61,300

Underlying: Common Stock · 61,300 shares

Expires 2030-06-17

F1 · derivative.exercise_date: The shares underlying the options vest in 12 equal (or as nearly equal as possible) monthly installments on the last calendar day of each month over a one-year period beginning on June 17, 2020.

SEC source: 0001437749-20-000403 · rdgdoc.xml · derivative · entry 1

Byrne Thomas E · CIK 0001663220 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2022-12-31

F1 · derivative.exercise_date: The shares underlying the options vest in 36 equal (or as nearly equal as possible) monthly installments on the last calendar day of each month over a three-year period beginning on January 1, 2020.

SEC source: 0001437749-20-000552 · rdgdoc.xml · derivative · entry 2

Cobuzzi Robert Joseph Jr. · CIK 0001799838 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 98,100

Underlying: Common Stock · 98,100 shares

Expires 2022-12-31

F2 · derivative.exercise_date: The shares underlying the restricted stock units vest in 6 equal (or as nearly equal as possible) quarterly installments on the last calendar day of each quarter over an 18-month period beginning on July 1, 2021.

SEC source: 0001437749-20-000552 · rdgdoc.xml · derivative · entry 1

Cobuzzi Robert Joseph Jr. · CIK 0001799838 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 118,600

Underlying: Common Stock · 118,600 shares

Expires 2021-06-30

F1 · derivative.exercise_date: The shares underlying the options vest in 18 equal (or as nearly equal as possible) monthly installments on the last calendar day of each month over an 18-month period beginning immediately.

SEC source: 0001437749-20-001423 · rdgdoc.xml · derivative · entry 1

Gainer John · CIK 0001662697 · Director · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 239,400

Underlying: Common Stock · 239,400 shares

Expires 2030-01-31

F1 · derivative.exercise_date: The shares underlying the options vest in 36 equal (or as nearly equal as possible) monthly installments on the last calendar day of each month over a three-year period beginning on January 31, 2020.

SEC source: 0001437749-20-001421 · rdgdoc.xml · derivative · entry 1

Kalergis David G · CIK 0001663574 · Director · Chairman and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 262,900

Underlying: Common Stock · 262,900 shares

Expires 2030-01-31

F1 · derivative.exercise_date: The shares underlying the options vest in 36 equal (or as nearly equal as possible) monthly installments on the last calendar day of each month over a three-year period beginning on January 31, 2020.

SEC source: 0001437749-20-001420 · rdgdoc.xml · derivative · entry 1

Hornung William Karl · CIK 0001612066 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,600

Underlying: Common Stock · 52,600 shares

Expires 2030-01-31

F1 · derivative.exercise_date: The shares underlying the options vest in 36 equal (or as nearly equal as possible) monthly installments on the last calendar day of each month over a three-year period beginning on January 31, 2020.

SEC source: 0001437749-19-014277 · rdgdoc.xml · derivative · entry 3

Giles Mark T · CIK 0001663219 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,100

Underlying: Common Stock · 13,100 shares

Expires 2029-06-13

F1 · derivative.exercise_date: The shares underlying the options vest in 12 equal (or as nearly equal as possible) monthly installments on the last calendar day of each month over a one-year period beginning on June 13, 2019.

SEC source: 0001437749-19-014279 · rdgdoc.xml · derivative · entry 3

Adams Robert W · CIK 0001663144 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,100

Underlying: Common Stock · 13,100 shares

Expires 2029-06-13

F1 · derivative.exercise_date: The shares underlying the options vest in 12 equal (or as nearly equal as possible) monthly installments on the last calendar day of each month over a one-year period beginning on June 13, 2019.

SEC source: 0001437749-19-014278 · rdgdoc.xml · derivative · entry 2

LEVIN ALAN G · CIK 0001174452 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,100

Underlying: Common Stock · 13,100 shares

Expires 2029-06-13

F1 · derivative.exercise_date: The shares underlying the options vest in 12 equal (or as nearly equal as possible) monthly installments on the last calendar day of each month over a one-year period beginning on June 13, 2019.

SEC source: 0001437749-19-015541 · rdgdoc.xml · derivative · entry 3

Adams Robert W · CIK 0001663144 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,200

Underlying: Common Stock · 19,200 shares

Expires 2029-06-13

F1 · derivative.exercise_date: The shares underlying the options vest in equal parts on the last calendar day of each month until fully vested on May 31, 2020.

SEC source: 0001437749-19-015539 · rdgdoc.xml · derivative · entry 2

LEVIN ALAN G · CIK 0001174452 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,200

Underlying: Common Stock · 19,200 shares

Expires 2029-06-13

F1 · derivative.exercise_date: The shares underlying the options vest in equal parts on the last calendar day of each month until fully vested on May 31, 2020.

SEC source: 0001437749-19-015540 · rdgdoc.xml · derivative · entry 3

Giles Mark T · CIK 0001663219 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,200

Underlying: Common Stock · 19,200 shares

Expires 2029-06-13

F1 · derivative.exercise_date: The shares underlying the options vest in equal parts on the last calendar day of each month until fully vested on May 31, 2020.

SEC source: 0001437749-19-001522 · rdgdoc.xml · derivative · entry 1

Byrne Thomas E · CIK 0001663220 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,667

Underlying: Common Stock · 2,667 shares

Expires 2029-01-02

F1 · derivative.exercise_date: The shares underlying the options vest in 36 equal (or as nearly equal as possible) monthly installments on the last calendar day of each month over a three-year period beginning on January 31, 2019.

SEC source: 0001437749-19-000343 · rdgdoc.xml · derivative · entry 1

Hornung William Karl · CIK 0001612066 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,334

Underlying: Common Stock · 16,334 shares

Expires 2029-01-02

F1 · derivative.exercise_date: The shares underlying the options vest in 36 equal (or as nearly equal as possible) monthly installments on the last calendar day of each month over a three-year period beginning on January 31, 2019.

SEC source: 0001437749-18-012015 · rdgdoc.xml · derivative · entry 1

Adams Robert W · CIK 0001663144 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2028-06-14

F1 · derivative.exercise_date: The shares underlying the options vest in 12 equal (or as nearly equal as possible) monthly installments over a one-year period beginning on the grant date, provided that the final tranche will vest on the day immediately prior to the subsequent annual meeting.

SEC source: 0001437749-18-012014 · rdgdoc.xml · derivative · entry 1

Giles Mark T · CIK 0001663219 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2028-06-14

F1 · derivative.exercise_date: The shares underlying the options vest in 12 equal (or as nearly equal as possible) monthly installments over a one-year period beginning on the grant date, provided that the final tranche will vest on the day immediately prior to the subsequent annual meeting.

SEC source: 0001437749-18-012013 · rdgdoc.xml · derivative · entry 1

LEVIN ALAN G · CIK 0001174452 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2028-06-14

F1 · derivative.exercise_date: The shares underlying the options vest in 12 equal (or as nearly equal as possible) monthly installments over a one-year period beginning on the grant date, provided that the final tranche will vest on the day immediately prior to the subsequent annual meeting.

SEC source: 0001437749-18-012012 · rdgdoc.xml · derivative · entry 1

RUFFOLO ROBERT R · CIK 0001187308 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2028-06-14

F1 · derivative.exercise_date: The shares underlying the options vest in 12 equal (or as nearly equal as possible) monthly installments over a one-year period beginning on the grant date, provided that the final tranche will vest on the day immediately prior to the subsequent annual meeting.

SEC source: 0001437749-18-000264 · rdgdoc.xml · derivative · entry 1

Byrne Thomas E · CIK 0001663220 · General Counsel

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

Underlying: Common Stock · 10,000 shares

Expires 2028-01-02

F1 · derivative.exercise_date: The shares underlying the options vest in 36 equal (or as nearly equal as possible) monthly installments on the last calendar day of each month over a three-year period beginning on January 31, 2018.

SEC source: 0001437749-18-000263 · rdgdoc.xml · derivative · entry 1

Shealy Ben · CIK 0001662678 · Sr VP Finance & Treasurer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2028-01-02

F1 · derivative.exercise_date: The shares underlying the options vest in 36 equal (or as nearly equal as possible) monthly installments on the last calendar day of each month over a three-year period beginning on January 31, 2018.

SEC source: 0001437749-18-000261 · rdgdoc.xml · derivative · entry 1

LEVIN ALAN G · CIK 0001174452 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2028-01-02

F1 · derivative.exercise_date: The shares underlying the options vest in 12 equal (or as nearly equal as possible) monthly installments on the last calendar day of each month over a one-year period beginning on January 31, 2018.

SEC source: 0001437749-18-000260 · rdgdoc.xml · derivative · entry 1

Gainer John · CIK 0001662697 · Director · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 45,000

Underlying: Common Stock · 45,000 shares

Expires 2028-01-02

F1 · derivative.exercise_date: The shares underlying the options vest in 36 equal (or as nearly equal as possible) monthly installments on the last calendar day of each month over a three-year period beginning on January 31, 2018.

SEC source: 0001437749-18-000256 · rdgdoc.xml · derivative · entry 1

Giles Mark T · CIK 0001663219 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2028-01-02

F1 · derivative.exercise_date: The shares underlying the options vest in 12 equal (or as nearly equal as possible) monthly installments on the last calendar day of each month over a one-year period beginning on January 31, 2018.

SEC source: 0001437749-18-000259 · rdgdoc.xml · derivative · entry 1

RUFFOLO ROBERT R · CIK 0001187308 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2028-01-02

F1 · derivative.exercise_date: The shares underlying the options vest in 12 equal (or as nearly equal as possible) monthly installments on the last calendar day of each month over a one-year period beginning on January 31, 2018.

SEC source: 0001437749-18-000258 · rdgdoc.xml · derivative · entry 1

Kalergis David G · CIK 0001663574 · Director · Chairman and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 55,000

Underlying: Common Stock · 55,000 shares

Expires 2028-01-02

F1 · derivative.exercise_date: The shares underlying the options vest in 36 equal (or as nearly equal as possible) monthly installments on the last calendar day of each month over a three-year period beginning on January 31, 2018.

SEC source: 0001437749-18-000257 · rdgdoc.xml · derivative · entry 1

Adams Robert W · CIK 0001663144 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

Underlying: Common Stock · 25,000 shares

Expires 2028-01-02

F1 · derivative.exercise_date: The shares underlying the options vest in 12 equal (or as nearly equal as possible) monthly installments on the last calendar day of each month over a one-year period beginning on January 31, 2018.

SEC source: 0001437749-17-012576 · rdgdoc.xml · derivative · entry 1

RUFFOLO ROBERT R · CIK 0001187308 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 52,057

Underlying: Common Stock · 52,057 shares

Expires 2027-06-29

F1 · derivative.exercise_date: The shares underlying the options vest in equal parts on the first three anniversaries of the grant date.

SEC source: 0001437749-17-011437 · rdgdoc.xml · derivative · entry 1

Giles Mark T · CIK 0001663219 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,900

Underlying: Common Stock · 23,900 shares

Expires 2027-06-15

F1 · derivative.exercise_date: The shares underlying the options vest in equal parts on the fifteenth day of each month until fully vested on June 15, 2018.

SEC source: 0001437749-17-011436 · rdgdoc.xml · derivative · entry 1

Adams Robert W · CIK 0001663144 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,900

Underlying: Common Stock · 23,900 shares

Expires 2027-06-15

F1 · derivative.exercise_date: The shares underlying the options vest in equal parts on the fifteenth day of each month until fully vested on June 15, 2018.

SEC source: 0001437749-17-011435 · rdgdoc.xml · derivative · entry 1

LEVIN ALAN G · CIK 0001174452 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,900

Underlying: Common Stock · 23,900 shares

Expires 2027-06-15

F1 · derivative.exercise_date: The shares underlying the options vest in equal parts on the fifteenth day of each month until fully vested on June 15, 2018.