CERT

SEC source: 0001415889-23-005808 · form4-04032023_080426.xml · nonDerivative · entry 1

SMITH PATRICK F · CIK 0001890360 · PRESIDENT, INTEGRATED DRUG DEV

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 73,327

F1 · shares: Represents restricted stock units ("RSUs") withheld to satisfy the tax withholding obligations in connection with the vesting and settlement of RSUs, exempt under Rule 16b-3. Each RSUs was granted on April 1, 2021, under the Certara, Inc. 2020 Incentive Plan (the "2020 Incentive Plan") and represents a right to receive one share of common stock or the cash equivalent thereof. One-third of the RSUs vested and were settled on April 1, 2022. One-third of the RSUs vested and were on March 31, 2023. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2024.

F2 · balance_after: The total reported in Column 5 includes 4,884 RSUs which was previously reported in Table 1 of Form 4.

SEC source: 0001415889-23-005805 · form4-04032023_080427.xml · derivative · entry 4

Traynor Richard M. · CIK 0001834465 · SVP AND GENERAL COUNSEL

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 13,302

Underlying: Common Stock · 6,651 shares

Expires 2025-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent thereof. One-third of the RSUs vested and were settled on March 31, 2023. The remaining two-thirds of the RSUs are scheduled to vest and settle in two equal installments on April 1, 2024, and April 1, 2025.

F3 · derivative.exercise_date: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent thereof. One-third of the RSUs vested and were settled on March 31, 2023. The remaining two-thirds of the RSUs are scheduled to vest and settle in two equal installments on April 1, 2024, and April 1, 2025.

SEC source: 0001415889-23-005805 · form4-04032023_080427.xml · nonDerivative · entry 3

Traynor Richard M. · CIK 0001834465 · SVP AND GENERAL COUNSEL

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 187,368

F4 · shares: Represents RSUs withheld to satisfy the tax withholding obligations in connection with the vesting and settlement of RSUs, exempt under Rule 16b-3.

F2 · balance_after: The total reported in Column 5 includes 5,495 RSUs which was previously reported in Table 1 of Form 4.

SEC source: 0001415889-23-005805 · form4-04032023_080427.xml · nonDerivative · entry 2

Traynor Richard M. · CIK 0001834465 · SVP AND GENERAL COUNSEL

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 189,492

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · shares: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent thereof. One-third of the RSUs vested and were settled on March 31, 2023. The remaining two-thirds of the RSUs are scheduled to vest and settle in two equal installments on April 1, 2024, and April 1, 2025.

F2 · balance_after: The total reported in Column 5 includes 5,495 RSUs which was previously reported in Table 1 of Form 4.

SEC source: 0001415889-23-005805 · form4-04032023_080427.xml · nonDerivative · entry 1

Traynor Richard M. · CIK 0001834465 · SVP AND GENERAL COUNSEL

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 182,841

F1 · shares: Represents restricted stock units ("RSUs") withheld to satisfy the tax withholding obligations in connection with the vesting and settlement of RSUs, exempt under Rule 16b-3. Each RSUs was granted on April 1, 2021, under the Certara, Inc. 2020 Incentive Plan (the "2020 Incentive Plan") and represents a right to receive one share of common stock or the cash equivalent thereof. One-third of the RSUs vested and were settled on April 1, 2022. One-third of the RSUs vested and were on March 31, 2023. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2024.

F2 · balance_after: The total reported in Column 5 includes 5,495 RSUs which was previously reported in Table 1 of Form 4.

SEC source: 0001415889-23-005801 · form4-04032023_080407.xml · derivative · entry 4

Aspbury Robert · CIK 0001834221 · PRESIDENT, SIMCYP

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 17,293

Underlying: Common Stock · 8,646 shares

Expires 2025-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent thereof. One-third of the RSUs vested and were settled on March 31, 2023. The remaining two-thirds of the RSUs are scheduled to vest and settle in two equal installments on April 1, 2024, and April 1, 2025.

F3 · derivative.exercise_date: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent thereof. One-third of the RSUs vested and were settled on March 31, 2023. The remaining two-thirds of the RSUs are scheduled to vest and settle in two equal installments on April 1, 2024, and April 1, 2025.

SEC source: 0001415889-23-005801 · form4-04032023_080407.xml · nonDerivative · entry 3

Aspbury Robert · CIK 0001834221 · PRESIDENT, SIMCYP

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 276,927

F4 · shares: Represents RSUs withheld to satisfy the tax withholding obligations in connection with the vesting and settlement of RSUs, exempt under Rule 16b-3.

F2 · balance_after: The total reported in Column 5 includes 9,769 RSUs which was previously reported in Table 1 of Form 4.

SEC source: 0001415889-23-005801 · form4-04032023_080407.xml · nonDerivative · entry 2

Aspbury Robert · CIK 0001834221 · PRESIDENT, SIMCYP

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 280,991

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · shares: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent thereof. One-third of the RSUs vested and were settled on March 31, 2023. The remaining two-thirds of the RSUs are scheduled to vest and settle in two equal installments on April 1, 2024, and April 1, 2025.

F2 · balance_after: The total reported in Column 5 includes 9,769 RSUs which was previously reported in Table 1 of Form 4.

SEC source: 0001415889-23-005801 · form4-04032023_080407.xml · nonDerivative · entry 1

Aspbury Robert · CIK 0001834221 · PRESIDENT, SIMCYP

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 272,345

F1 · shares: Represents restricted stock units ("RSUs") withheld to satisfy the tax withholding obligations in connection with the vesting and settlement of RSUs, exempt under Rule 16b-3. Each RSUs was granted on April 1, 2021, under the Certara, Inc. 2020 Incentive Plan (the "2020 Incentive Plan") and represents a right to receive one share of common stock or the cash equivalent thereof. One-third of the RSUs vested and were settled on April 1, 2022. One-third of the RSUs vested and were on March 31, 2023. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2024.

F2 · balance_after: The total reported in Column 5 includes 9,769 RSUs which was previously reported in Table 1 of Form 4.

SEC source: 0001415889-23-005799 · form4-04032023_080439.xml · derivative · entry 4

Schemick Michael Andrew · CIK 0001834300 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 26,604

Underlying: Common Stock · 13,302 shares

Expires 2025-04-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_price: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent thereof. One-third of the RSUs vested and were settled on March 31, 2023. The remaining two-thirds of the RSUs are scheduled to vest and settle in two equal installments on April 1, 2024, and April 1, 2025.

F3 · derivative.exercise_date: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent thereof. One-third of the RSUs vested and were settled on March 31, 2023. The remaining two-thirds of the RSUs are scheduled to vest and settle in two equal installments on April 1, 2024, and April 1, 2025.

SEC source: 0001415889-23-005799 · form4-04032023_080439.xml · nonDerivative · entry 3

Schemick Michael Andrew · CIK 0001834300 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 522,895

F4 · kind: Represents RSUs withheld to satisfy the tax withholding obligations in connection with the vesting and settlement of RSUs, exempt under Rule 16b-3.

F2 · balance_after: The total reported in Column 5 includes 11,600 RSUs which was previously reported in Table 1 of Form 4.

SEC source: 0001415889-23-005799 · form4-04032023_080439.xml · nonDerivative · entry 2

Schemick Michael Andrew · CIK 0001834300 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 527,451

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · price: Each RSU was granted on April 1, 2022, under the 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent thereof. One-third of the RSUs vested and were settled on March 31, 2023. The remaining two-thirds of the RSUs are scheduled to vest and settle in two equal installments on April 1, 2024, and April 1, 2025.

F2 · balance_after: The total reported in Column 5 includes 11,600 RSUs which was previously reported in Table 1 of Form 4.

SEC source: 0001415889-23-005799 · form4-04032023_080439.xml · nonDerivative · entry 1

Schemick Michael Andrew · CIK 0001834300 · CHIEF FINANCIAL OFFICER

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 514,149

F1 · kind: Represents restricted stock units ("RSUs") withheld to satisfy the tax withholding obligations in connection with the vesting and settlement of RSUs, exempt under Rule 16b-3. Each RSUs was granted on April 1, 2021, under the Certara, Inc. 2020 Incentive Plan (the "2020 Incentive Plan") and represents a right to receive one share of common stock or the cash equivalent thereof. One-third of the RSUs vested and were settled on April 1, 2022. One-third of the RSUs vested and were on March 31, 2023. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2024.

F1 · shares: Represents restricted stock units ("RSUs") withheld to satisfy the tax withholding obligations in connection with the vesting and settlement of RSUs, exempt under Rule 16b-3. Each RSUs was granted on April 1, 2021, under the Certara, Inc. 2020 Incentive Plan (the "2020 Incentive Plan") and represents a right to receive one share of common stock or the cash equivalent thereof. One-third of the RSUs vested and were settled on April 1, 2022. One-third of the RSUs vested and were on March 31, 2023. The remaining one-third of the RSUs are scheduled to vest and settle on April 1, 2024.

F2 · balance_after: The total reported in Column 5 includes 11,600 RSUs which was previously reported in Table 1 of Form 4.

SEC source: 0001415889-23-004425 · form4-03072023_090323.xml · nonDerivative · entry 1

Traynor Richard M. · CIK 0001834465 · SVP AND GENERAL COUNSEL

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 184,564

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 11, 2022.

SEC source: 0001415889-23-001930 · form4-02032023_090209.xml · nonDerivative · entry 1

Traynor Richard M. · CIK 0001834465 · SVP AND GENERAL COUNSEL

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 194,564

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 11, 2022.

SEC source: 0001104659-22-126283 · tm2232484-1_4seq1.xml · nonDerivative · entry 1

EQT Avatar Parent L.P. · CIK 0001715533 · 10% owner

EQT Avatar Parent GP LLC · CIK 0001833933 · 10% owner

EQT Fund Management S.a r.l. · CIK 0001834239 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by EQT Avatar Parent L.P.

Disclosed balance after: 0

F1 · price: The sale was executed in a single block trade at $15.00 per share.

F2 · ownership.nature: Consists of shares of common stock held directly by EQT Avatar Parent L.P. ("EQT Investor"). EQT Avatar Parent GP LLC ("Avatar Parent GP") is the general partner of the EQT Investor. Several investment vehicles collectively make up the fund known as "EQT VII." EQT VII owns 100% of the membership interests in Avatar Parent GP. EQT Fund Management S.a r.l. ("EFMS") has exclusive responsibility for the management and control of the business and affairs of investment vehicles which constitute the majority of the total commitments to EQT VII. As such, EFMS has the power to control Avatar Parent GP's voting and investment decisions and may be deemed to have beneficial ownership of the securities held by the EQT Investor.

SEC source: 0001415889-22-011748 · form4-11232022_091140.xml · nonDerivative · entry 1

Pedersen Leif E · CIK 0001559712 · PRESIDENT, SOFTWARE

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 175,500

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 23, 2022.

F2 · price: This transaction was executed in multiple trades at prices ranging from $15.28 to $15.69. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-011442 · form4-11162022_091140.xml · nonDerivative · entry 2

SLAINE MASON P · CIK 0001079093 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 660,322

F2 · price: This transaction was executed in multiple trades at prices ranging from $15.25 to $15.81. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-011400 · form4-11152022_091148.xml · nonDerivative · entry 1

WALSH MATTHEW M · CIK 0001269428 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 167,901

F1 · price: This transaction was executed in multiple trades at prices ranging from $14.66 to $14.88. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-011442 · form4-11162022_091140.xml · nonDerivative · entry 1

SLAINE MASON P · CIK 0001079093 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 906,115

F1 · price: This transaction was executed in multiple trades at prices ranging from $15.25 to $15.32. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-011348 · form4-11142022_091110.xml · nonDerivative · entry 1

SMITH PATRICK F · CIK 0001890360 · PRESIDENT, INTEGRATED DRUG DEV

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 74,859

F1 · kind: The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 5, 2022.

SEC source: 0001415889-22-011013 · form4-11022022_011117.xml · nonDerivative · entry 1

SMITH PATRICK F · CIK 0001890360 · PRESIDENT, INTEGRATED DRUG DEV

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 77,246

F1 · shares: Represents restricted stock units ("RSUs") withheld to satisfy the tax withholding obligations in connection with the vesting and settlement of 3,631 RSUs. The RSUs were granted on November 1, 2021, subject to one-year cliff vesting.

F2 · balance_after: The total reported in column 5 includes 45,404 shares of common stock, 22,074 restricted stock and 9,768 RSUs, each of which was previously reported in Table 1 of Form 4.

SEC source: 0001415889-22-010383 · form4-10062022_011002.xml · derivative · entry 1

Virkler Drayton · CIK 0001945604 · INTERIM PRESIDENT, REG & ACCES

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,440

Underlying: Common Stock · 17,440 shares

Expires 2025-10-04

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") was granted under the Certara, Inc. 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent thereof.

F2 · derivative.exercise_date: The RSUs are scheduled to vest and settle in three equal installments on October 4, 2023, October 4, 2024, and October 4, 2025.

SEC source: 0001415889-22-010245 · form4-10042022_021054.xml · derivative · entry 5

Virkler Drayton · CIK 0001945604 · INTERIM PRESIDENT, REG & ACCES

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,042

Underlying: Common Stock · 3,021 shares

Expires 2024-10-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · derivative.exercise_price: Each RSU was granted under the Certara, Inc. 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent thereof. One-third of the RSUs vested and were settled on September 30, 2022. The remaining two-thirds of the RSUs are scheduled to vest and settle on October 1, 2023 and October 1, 2024, subject to the continued service of the reporting person.

F2 · derivative.exercise_date: Each RSU was granted under the Certara, Inc. 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent thereof. One-third of the RSUs vested and were settled on September 30, 2022. The remaining two-thirds of the RSUs are scheduled to vest and settle on October 1, 2023 and October 1, 2024, subject to the continued service of the reporting person.

SEC source: 0001415889-22-010245 · form4-10042022_021054.xml · derivative · entry 4

Virkler Drayton · CIK 0001945604 · INTERIM PRESIDENT, REG & ACCES

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 10,574 shares

Expires 2022-10-01

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each restricted stock unit ("RSUs") was granted under the Certara, Inc. 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent thereof. The RSUs were granted on October 1, 2021 and cliff vested and settled on September 30, 2022.

F1 · derivative.exercise_date: Each restricted stock unit ("RSUs") was granted under the Certara, Inc. 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent thereof. The RSUs were granted on October 1, 2021 and cliff vested and settled on September 30, 2022.

SEC source: 0001415889-22-010245 · form4-10042022_021054.xml · nonDerivative · entry 3

Virkler Drayton · CIK 0001945604 · INTERIM PRESIDENT, REG & ACCES

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,591

F3 · kind: Represents RSUs of the reporting company withheld to satisfy tax withholding obligations in connection with the vesting of RSUs described in footnotes 1 and 2, exempt from Rule 16b-3.

SEC source: 0001415889-22-010245 · form4-10042022_021054.xml · nonDerivative · entry 2

Virkler Drayton · CIK 0001945604 · INTERIM PRESIDENT, REG & ACCES

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 13,595

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F2 · price: Each RSU was granted under the Certara, Inc. 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent thereof. One-third of the RSUs vested and were settled on September 30, 2022. The remaining two-thirds of the RSUs are scheduled to vest and settle on October 1, 2023 and October 1, 2024, subject to the continued service of the reporting person.

SEC source: 0001415889-22-010245 · form4-10042022_021054.xml · nonDerivative · entry 1

Virkler Drayton · CIK 0001945604 · INTERIM PRESIDENT, REG & ACCES

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,574

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each restricted stock unit ("RSUs") was granted under the Certara, Inc. 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent thereof. The RSUs were granted on October 1, 2021 and cliff vested and settled on September 30, 2022.

SEC source: 0001415889-22-008945 · form4-08232022_050813.xml · nonDerivative · entry 1

McLean Stephen M. · CIK 0001834266 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 42,000

SEC source: 0001415889-22-008827 · form4-08182022_020814.xml · nonDerivative · entry 1

Schemick Michael Andrew · CIK 0001834300 · CHIEF FINANCIAL OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 517,870

F1 · price: The price reported is a weighted average price. The shares were purchased in multiple open market transactions at prices ranging from $16.57 to $16.67. The reporting person undertakes to provide, upon request, to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares purchased and the prices at which the transaction was effected.

SEC source: 0001104659-22-092229 · tm2223687-1_4seq1.xml · nonDerivative · entry 1

SLAINE MASON P · CIK 0001079093 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 910,322

F1 · price: This amount represents the $17.75 public offering price per share of common stock of Certara, Inc., less the underwriting discount of $0.37 per share.

SEC source: 0001104659-22-092231 · tm2223687-2_4seq1.xml · nonDerivative · entry 1

EQT Avatar Parent L.P. · CIK 0001715533 · 10% owner

EQT Avatar Parent GP LLC · CIK 0001833933 · 10% owner

EQT Fund Management S.a r.l. · CIK 0001834239 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by EQT Avatar Parent L.P.

Disclosed balance after: 29,954,521

F1 · price: This amount represents the $17.75 public offering price per share of common stock of Certara, Inc., less the underwriting discount of $0.37 per share.

F2 · ownership.nature: Consists of shares of common stock held directly by EQT Avatar Parent L.P. ("EQT Investor"). EQT Avatar Parent GP LLC ("Avatar Parent GP") is the general partner of the EQT Investor. Several investment vehicles collectively make up the fund known as "EQT VII." EQT VII owns 100% of the membership interests in Avatar Parent GP. EQT Fund Management S.a r.l. ("EFMS") has exclusive responsibility for the management and control of the business and affairs of investment vehicles which constitute the majority of the total commitments to EQT VII. As such, EFMS has the power to control Avatar Parent GP's voting and investment decisions and may be deemed to have beneficial ownership of the securities held by the EQT Investor.

SEC source: 0001415889-22-008824 · form4-08182022_020839.xml · nonDerivative · entry 1

SMITH PATRICK F · CIK 0001890360 · PRESIDENT, INTEGRATED DRUG DEV

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 78,490

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 11, 2022.

SEC source: 0001415889-22-008129 · form4-08022022_020805.xml · nonDerivative · entry 2

SHERMAN NICOLETTE D · CIK 0001872604 · CHIEF HUMAN RESOURCES OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,808

F2 · shares: Represents RSUs withheld to satisfy the tax withholding obligations in connection with the vesting and settlement of 5,513 RSUs. The RSUs were granted on August 1, 2021, subject to one year cliff vesting.

SEC source: 0001415889-22-008129 · form4-08022022_020805.xml · nonDerivative · entry 1

SHERMAN NICOLETTE D · CIK 0001872604 · CHIEF HUMAN RESOURCES OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,563

F1 · shares: Represents restricted stock units ("RSUs") withheld to satisfy the tax withholding obligations in connection with the vesting and settlement of 3,369 RSUs, previously granted to the reporting person on August 1, 2021. The remaining two-thirds of the RSUs are scheduled to vest and settle in two equal installments on August 1, 2023 and August 1, 2024.

SEC source: 0001415889-22-007919 · form4-07222022_010703.xml · derivative · entry 1

Crane Rosemary A · CIK 0001443343 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,324

Underlying: Common Stock · 9,324 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of common stock.

F2 · shares: Represents 9,324 RSUs granted under the Certara Inc. 2020 Incentive Plan that will entitle the reporting person to receive one share of the Issuer's Common Stock per RSU. The RSUs will vest on the earlier of the one-year anniversary of the date of grant or the date of the Issuer's next annual shareholder meeting.

F3 · derivative.exercise_date: The RSUs will vest on the earlier of the one-year anniversary of the date of grant or the date of the Issuer's next annual shareholder meeting.

F3 · derivative.expiration_date: The RSUs will vest on the earlier of the one-year anniversary of the date of grant or the date of the Issuer's next annual shareholder meeting.

SEC source: 0001415889-22-007690 · form4-07152022_010709.xml · derivative · entry 1

BROSHY ERAN · CIK 0001256230 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,360

Underlying: Common Stock · 9,360 shares

Expires not disclosed

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") represents a contingent right to receive one share of common stock.

F2 · shares: Represents 9,360 RSUs granted under the Certara Inc. 2020 Incentive Plan that will entitle the reporting person to receive one share of the Issuer's Common Stock per RSU. The RSUs will vest on the earlier of the one-year anniversary of the date of grant or the date of the Issuer's next annual shareholder meeting.

F3 · derivative.exercise_date: The RSUs will vest on the earlier of the one-year anniversary of the date of grant or the date of the Issuer's next annual shareholder meeting.

F3 · derivative.expiration_date: The RSUs will vest on the earlier of the one-year anniversary of the date of grant or the date of the Issuer's next annual shareholder meeting.

SEC source: 0001415889-22-007359 · form4-07052022_010705.xml · nonDerivative · entry 1

Aspbury Robert · CIK 0001834221 · PRESIDENT, SIMCYP

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 275,215

F1 · shares: Represents restricted stock units ("RSU") withheld to satisfy tax withholding obligations in connection with the vesting and settlement of 1,831 RSUs, previously granted to the reporting person on July 1, 2021. The remaining two-thirds of the RSUs are scheduled to vest and settle in two equal installments on July 1, 2023 and July 1, 2024.

SEC source: 0001415889-22-006381 · form4-06092022_010628.xml · nonDerivative · entry 1

SMITH PATRICK F · CIK 0001890360 · PRESIDENT, INTEGRATED DRUG DEV

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 88,490

F1 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on March 7, 2022.

SEC source: 0001415889-22-006114 · form4-06032022_010641.xml · nonDerivative · entry 3

SLAINE MASON P · CIK 0001079093 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,092,797

F3 · price: This transaction was executed in multiple trades at prices ranging from $19.42 to $19.66. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-006114 · form4-06032022_010641.xml · nonDerivative · entry 2

SLAINE MASON P · CIK 0001079093 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,142,797

F2 · price: This transaction was executed in multiple trades at prices ranging from $19.42 to $19.75. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001415889-22-006114 · form4-06032022_010641.xml · nonDerivative · entry 1

SLAINE MASON P · CIK 0001079093 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,242,797

F1 · price: This transaction was executed in multiple trades at prices ranging from $19.23 to $19.83. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected.

SEC source: 0001104659-22-067234 · tm2217488-1_4seq1.xml · nonDerivative · entry 1

EQT Avatar Parent L.P. · CIK 0001715533 · 10% owner

EQT Avatar Parent GP LLC · CIK 0001833933 · 10% owner

EQT Fund Management S.a r.l. · CIK 0001834239 · 10% owner

Joint disclosure: these amounts are not allocated separately to each reporting owner.

10b5-1 filing: Not disclosed

Ownership: Indirect · Held by EQT Avatar Parent L.P.

Disclosed balance after: 35,958,939

F1 · ownership.nature: Consists of shares of common stock held directly by EQT Avatar Parent L.P. ("EQT Investor"). EQT Avatar Parent GP LLC ("Avatar Parent GP") is the general partner of the EQT Investor. Several investment vehicles collectively make up the fund known as "EQT VII." EQT VII owns 100% of the membership interests in Avatar Parent GP. EQT Fund Management S.a r.l. ("EFMS") has exclusive responsibility for the management and control of the business and affairs of investment vehicles which constitute the majority of the total commitments to EQT VII. As such, EFMS has the power to control Avatar Parent GP's voting and investment decisions and may be deemed to have beneficial ownership of the securities held by the EQT Investor.

SEC source: 0001415889-22-005236 · form4-05182022_010518.xml · derivative · entry 2

SLAINE MASON P · CIK 0001079093 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,067

Underlying: Common Stock · 9,067 shares

Expires not disclosed

F2 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of common stock.

F3 · shares: Represents 9,067 RSUs granted under the Certara Inc. 2020 Incentive Plan that will entitle the reporting person to receive one share of the Issuer's Common Stock per RSU. The RSUs will vest on the earlier of the one-year anniversary of the date of grant or the date of the Company's next annual shareholder meeting. The reporting person has reported prior awards of RSUs in Table 1 of Form 4.

F4 · derivative.exercise_date: The RSUs will vest on the earlier of the one-year anniversary of the date of grant or the date of the Company's next annual shareholder meeting.

F4 · derivative.expiration_date: The RSUs will vest on the earlier of the one-year anniversary of the date of grant or the date of the Company's next annual shareholder meeting.

SEC source: 0001415889-22-005245 · form4-05182022_010540.xml · derivative · entry 2

Collins Cynthia · CIK 0001405692 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,067

Underlying: Common Stock · 9,067 shares

Expires not disclosed

F2 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of common stock.

F3 · shares: Represents 9,067 RSUs granted under the Certara Inc. 2020 Incentive Plan that will entitle the reporting person to receive one share of the Issuer's Common Stock per RSU. The RSUs will vest on the earlier of the one-year anniversary of the date of grant or the date of the Company's next annual shareholder meeting. The reporting person has reported prior awards of RSUs in Table 1 of Form 4.

F4 · derivative.exercise_date: The RSUs will vest on the earlier of the one-year anniversary of the date of grant or the date of the Company's next annual shareholder meeting.

F4 · derivative.expiration_date: The RSUs will vest on the earlier of the one-year anniversary of the date of grant or the date of the Company's next annual shareholder meeting.

SEC source: 0001415889-22-005247 · form4-05182022_010541.xml · derivative · entry 2

WALSH MATTHEW M · CIK 0001269428 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,067

Underlying: Common Stock · 9,067 shares

Expires not disclosed

F2 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of common stock.

F3 · shares: Represents 9,067 RSUs granted under the Certara Inc. 2020 Incentive Plan that will entitle the reporting person to receive one share of the Issuer's Common Stock per RSU. The RSUs will vest on the earlier of the one-year anniversary of the date of grant or the date of the Company's next annual shareholder meeting. The reporting person has reported prior awards of RSUs in Table 1 of Form 4.

F4 · derivative.exercise_date: The RSUs will vest on the earlier of the one-year anniversary of the date of grant or the date of the Company's next annual shareholder meeting.

F4 · derivative.expiration_date: The RSUs will vest on the earlier of the one-year anniversary of the date of grant or the date of the Company's next annual shareholder meeting.

SEC source: 0001415889-22-005238 · form4-05182022_010551.xml · derivative · entry 2

CASHMAN JAMES E III · CIK 0001199440 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,067

Underlying: Common Stock · 9,067 shares

Expires not disclosed

F2 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of common stock.

F3 · shares: Represents 9,067 RSUs granted under the Certara Inc. 2020 Incentive Plan that will entitle the reporting person to receive one share of the Issuer's Common Stock per RSU. The RSUs will vest on the earlier of the one-year anniversary of the date of grant or the date of the Company's next annual shareholder meeting. The reporting person has reported prior awards of RSUs in Table 1 of Form 4.

F4 · derivative.exercise_date: The RSUs will vest on the earlier of the one-year anniversary of the date of grant or the date of the Company's next annual shareholder meeting.

F4 · derivative.expiration_date: The RSUs will vest on the earlier of the one-year anniversary of the date of grant or the date of the Company's next annual shareholder meeting.

SEC source: 0001415889-22-005243 · form4-05182022_010554.xml · derivative · entry 2

Killefer Nancy · CIK 0001584637 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,067

Underlying: Common Stock · 9,067 shares

Expires not disclosed

F2 · derivative.exercise_price: Each RSU represents a contingent right to receive one share of common stock.

F3 · shares: Represents 9,067 RSUs granted under the Certara Inc. 2020 Incentive Plan that will entitle the reporting person to receive one share of the Issuer's Common Stock per RSU. The RSUs will vest on the earlier of the one-year anniversary of the date of grant or the date of the Company's next annual shareholder meeting. The reporting person has reported prior awards of RSUs in Table 1 of Form 4.

F4 · derivative.exercise_date: The RSUs will vest on the earlier of the one-year anniversary of the date of grant or the date of the Company's next annual shareholder meeting.

F4 · derivative.expiration_date: The RSUs will vest on the earlier of the one-year anniversary of the date of grant or the date of the Company's next annual shareholder meeting.

SEC source: 0001415889-22-003827 · form4-04052022_010425.xml · nonDerivative · entry 2

SMITH PATRICK F · CIK 0001890360 · PRESIDENT, INTEGRATED DRUG DEV

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 98,490

F3 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 11, 2021.

F4 · balance_after: The total reported in Column 5 includes 85,091 shares of common stock and 13,399 RSUs, each of which was previously reported in Table 1 of Form 4. Does not include 25,939 newly-awarded RSUs which are reported in Table II.

SEC source: 0001415889-22-003829 · form4-04052022_010456.xml · derivative · entry 1

SHERMAN NICOLETTE D · CIK 0001872604 · CHIEF HUMAN RESOURCES OFFICER

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 11,972

Underlying: Common Stock · 11,972 shares

Expires 2025-04-01

F1 · derivative.exercise_price: Each restricted stock unit ("RSU") is granted under the Certara, Inc. 2020 Incentive Plan and represents a right to receive one share of common stock or the cash equivalent thereof. The reporting person has reported prior awards of RSUs in Table 1 of Form 4.

F2 · derivative.exercise_date: The RSUs will vest and settle in three equal installments on April 1, 2023, April 1, 2024 and April 1, 2025.