CADL

SEC source: 0001209191-22-053830 · doc4.xml · derivative · entry 1

Nguyen Diem · CIK 0001814338 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,240

Underlying: Common Stock · 14,240 shares

Expires 2032-10-13

F1 · derivative.exercise_date: This option is subject to time-based vesting. The shares underlying this option shall vest and become exercisable upon the earlier of (i) October 13, 2023 or (ii) the date of the next Annual Meeting of Stockholders of the Company; provided, however, that all vesting shall cease if the Reporting Person resigns from the Board of Directors of the Company or otherwise ceases to serve as a Director, unless the Board determines that the circumstances warrant continuation of vesting.

SEC source: 0001209191-22-053831 · doc4.xml · derivative · entry 1

Martell Christopher · CIK 0001873465 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,240

Underlying: Common Stock · 14,240 shares

Expires 2032-10-13

F1 · derivative.exercise_date: This option is subject to time-based vesting. The shares underlying this option shall vest and become exercisable upon the earlier of (i) October 13, 2023 or (ii) the date of the next Annual Meeting of Stockholders of the Company; provided, however, that all vesting shall cease if the Reporting Person resigns from the Board of Directors of the Company or otherwise ceases to serve as a Director, unless the Board determines that the circumstances warrant continuation of vesting.

SEC source: 0001209191-22-053829 · doc4.xml · derivative · entry 1

Benz Edward J. JR · CIK 0001691160 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,240

Underlying: Common Stock · 14,240 shares

Expires 2032-10-13

F1 · derivative.exercise_date: This option is subject to time-based vesting. The shares underlying this option shall vest and become exercisable upon the earlier of (i) October 13, 2023 or (ii) the date of the next Annual Meeting of Stockholders of the Company; provided, however, that all vesting shall cease if the Reporting Person resigns from the Board of Directors of the Company or otherwise ceases to serve as a Director, unless the Board determines that the circumstances warrant continuation of vesting.

SEC source: 0001209191-22-053828 · doc4.xml · derivative · entry 1

Manning Paul B · CIK 0001494695 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,240

Underlying: Common Stock · 14,240 shares

Expires 2032-10-13

F1 · derivative.exercise_date: This option is subject to time-based vesting. The shares underlying this option shall vest and become exercisable upon the earlier of (i) October 13, 2023 or (ii) the date of the next Annual Meeting of Stockholders of the Company; provided, however, that all vesting shall cease if the Reporting Person resigns from the Board of Directors of the Company or otherwise ceases to serve as a Director, unless the Board determines that the circumstances warrant continuation of vesting.

SEC source: 0001209191-22-053833 · doc4.xml · derivative · entry 1

Aguilar-Cordova Estuardo · CIK 0001873919 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,240

Underlying: Common Stock · 14,240 shares

Expires 2032-10-13

F1 · derivative.exercise_date: This option is subject to time-based vesting. The shares underlying this option shall vest and become exercisable upon the earlier of (i) October 13, 2023 or (ii) the date of the next Annual Meeting of Stockholders of the Company; provided, however, that all vesting shall cease if the Reporting Person resigns from the Board of Directors of the Company or otherwise ceases to serve as a Director, unless the Board determines that the circumstances warrant continuation of vesting.

SEC source: 0001209191-22-051131 · doc4.xml · derivative · entry 1

Amello Jason · CIK 0001451805 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 230,000

Underlying: Common Stock · 230,000 shares

Expires 2032-09-21

F1 · derivative.exercise_date: 25% of the shares underlying this option shall vest and become exercisable on September 21, 2023, with the remainder vesting in thirty-six (36) equal monthly installments thereafter, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0000899243-22-031059 · doc4.xml · derivative · entry 1

Nichols William Garrett · CIK 0001618364 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 200,000

Underlying: Common Stock · 200,000 shares

Expires 2032-09-12

F1 · derivative.exercise_date: The first 100,000 shares underlying this option shall vest as follows: 25% shall vest and become exercisable on September 12, 2023, with the remainder vesting in thirty-six (36) equal monthly installments thereafter, subject to the Reporting Person's continued service on each such vesting date. The remaining 100,000 shares underlying this option shall vest as follows: 25% shall vest and become exercisable on the first anniversary of the date in which the Reporting Person converts to a full-time employee, with the remainder vesting in thirty-six (36) equal monthly installments thereafter, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0000899243-22-028203 · doc4.xml · derivative · entry 1

Gaeta Renee · CIK 0001742428 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,480

Underlying: Common Stock · 28,480 shares

Expires 2032-08-08

F1 · derivative.exercise_date: 33% of the shares underlying this option shall vest and become exercisable on August 8, 2023, with the remainder vesting in two (2) equal annual installments thereafter, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0000899243-22-028201 · doc4.xml · derivative · entry 1

PAPA JOSEPH C · CIK 0001242215 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,480

Underlying: Common Stock · 28,480 shares

Expires 2032-08-08

F1 · derivative.exercise_date: 33% of the shares underlying this option shall vest and become exercisable on August 8, 2023, with the remainder vesting in two (2) equal annual installments thereafter, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0000899243-22-028202 · doc4.xml · derivative · entry 1

Nabel Gary J. · CIK 0001867450 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,480

Underlying: Common Stock · 28,480 shares

Expires 2032-08-08

F1 · derivative.exercise_date: 33% of the shares underlying this option shall vest and become exercisable on August 8, 2023, with the remainder vesting in two (2) equal annual installments thereafter, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0000899243-22-017477 · doc4.xml · derivative · entry 6

Aguilar Laura K. · CIK 0001873915 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 76,717 shares

Expires 2028-11-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · shares: Includes options that were previously subject to performance vesting criteria. Upon the Reporting Person's termination as an officer of the Issuer, the vesting conditions were waived, and the shares underlying this option became fully vested and exercisable.

F4 · derivative.exercise_date: This option is fully vested and exercisable as of the date hereof.

SEC source: 0000899243-22-017477 · doc4.xml · derivative · entry 5

Aguilar Laura K. · CIK 0001873915 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 76,717 shares

Expires 2028-11-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: This option is fully vested and exercisable as of the date hereof.

SEC source: 0000899243-22-017477 · doc4.xml · derivative · entry 4

Aguilar Laura K. · CIK 0001873915 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 17,901 shares

Expires 2028-08-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: This option is fully vested and exercisable as of the date hereof.

SEC source: 0000899243-22-017477 · doc4.xml · nonDerivative · entry 2

Aguilar Laura K. · CIK 0001873915 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,033,840

F2 · kind: Represents a net exercise of outstanding stock options. These shares were resold to the Issuer as payment of the exercise price, based on the closing price of the Issuer's common stock on May 5, 2022 of $3.65 per share.

F1 · balance_after: Includes 32,399 shares of common stock held jointly with spouse.

SEC source: 0000899243-22-017477 · doc4.xml · nonDerivative · entry 1

Aguilar Laura K. · CIK 0001873915 · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,102,374

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 32,399 shares of common stock held jointly with spouse.

SEC source: 0000899243-22-017474 · doc4.xml · derivative · entry 6

Aguilar-Cordova Estuardo · CIK 0001873919 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,456

Underlying: Common Stock · 46,261 shares

Expires 2023-11-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F5 · shares: Includes options that were previously subject to performance vesting criteria. Upon the Reporting Person's termination as an officer of the Issuer, the vesting conditions were waived, and the shares underlying this option became fully vested and exercisable.

F4 · derivative.exercise_date: This option is fully vested and exercisable as of the date hereof.

SEC source: 0000899243-22-017474 · doc4.xml · derivative · entry 5

Aguilar-Cordova Estuardo · CIK 0001873919 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 76,717 shares

Expires 2023-11-13

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: This option is fully vested and exercisable as of the date hereof.

SEC source: 0000899243-22-017474 · doc4.xml · derivative · entry 4

Aguilar-Cordova Estuardo · CIK 0001873919 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 12,205 shares

Expires 2028-08-17

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: This option is fully vested and exercisable as of the date hereof.

SEC source: 0000899243-22-017474 · doc4.xml · nonDerivative · entry 2

Aguilar-Cordova Estuardo · CIK 0001873919 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,097,032

F2 · kind: Represents a net exercise of outstanding stock options. These shares were resold to the Issuer as payment of the exercise price, based on the closing price of the Issuer's common stock on May 5, 2022 of $3.65 per share.

F1 · balance_after: Includes 32,399 shares of common stock held jointly with spouse.

SEC source: 0000899243-22-017474 · doc4.xml · nonDerivative · entry 1

Aguilar-Cordova Estuardo · CIK 0001873919 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,151,106

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · balance_after: Includes 32,399 shares of common stock held jointly with spouse.

SEC source: 0000899243-22-014892 · doc4.xml · derivative · entry 1

Tyagarajan Seshu · CIK 0001923794 · See Remarks

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 120,000

Underlying: Common Stock · 120,000 shares

Expires 2032-04-14

F1 · derivative.exercise_date: 25% of the shares underlying this option shall vest and become exercisable on April 14, 2023, with the remainder vesting in thirty-six (36) equal monthly installments thereafter, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0000899243-22-014591 · doc4.xml · derivative · entry 1

Stewart Susan B. · CIK 0001618249 · Chief Regulatory Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2032-04-11

F1 · derivative.exercise_date: The shares underlying this option shall vest and become exercisable in forty-eight (48) equal monthly installments, with the first installment vesting on May 11, 2022, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0000899243-22-008370 · doc4.xml · derivative · entry 1

Barone Francesca · CIK 0001909680 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 110,000

Underlying: Common Stock · 110,000 shares

Expires 2032-02-28

F1 · derivative.exercise_date: This option is subject to time-based and performance-based vesting. The shares underlying this option shall vest and become exercisable in forty-eight (48) equal monthly installments following the Grant Date, subject to the Reporting Person's continued service on each such vesting date; provided, however, that one-third of the shares underlying this option shall only become exercisable if the average market price of the Issuer's common stock equals or exceeds $13.50 for any ten consecutive trading days prior to or as of December 31, 2022, and an additional one-third of the shares underlying this option shall only become exercisable if the average market price of the Issuer's common stock equals or exceeds $20.00 for any ten consecutive trading days prior to or as of December 31, 2022.

SEC source: 0000899243-22-008377 · doc4.xml · derivative · entry 1

Canepa John J · CIK 0001589238 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 110,000

Underlying: Common Stock · 110,000 shares

Expires 2032-02-28

F1 · derivative.exercise_date: This option is subject to time-based and performance-based vesting. The shares underlying this option shall vest and become exercisable in forty-eight (48) equal monthly installments following the Grant Date, subject to the Reporting Person's continued service on each such vesting date; provided, however, that one-third of the shares underlying this option shall only become exercisable if the average market price of the Issuer's common stock equals or exceeds $13.50 for any ten consecutive trading days prior to or as of December 31, 2022, and an additional one-third of the shares underlying this option shall only become exercisable if the average market price of the Issuer's common stock equals or exceeds $20.00 for any ten consecutive trading days prior to or as of December 31, 2022.

SEC source: 0000899243-22-008373 · doc4.xml · derivative · entry 1

Tak Paul Peter · CIK 0001873905 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 330,000

Underlying: Common Stock · 330,000 shares

Expires 2032-02-28

F1 · derivative.exercise_date: This option is subject to time-based and performance-based vesting. The shares underlying this option shall vest and become exercisable in forty-eight (48) equal monthly installments following the Grant Date, subject to the Reporting Person's continued service on each such vesting date; provided, however, that one-third of the shares underlying this option shall only become exercisable if the average market price of the Issuer's common stock equals or exceeds $13.50 for any ten consecutive trading days prior to or as of December 31, 2022, and an additional one-third of the shares underlying this option shall only become exercisable if the average market price of the Issuer's common stock equals or exceeds $20.00 for any ten consecutive trading days prior to or as of December 31, 2022.

SEC source: 0000899243-22-005079 · doc4.xml · derivative · entry 1

Barone Francesca · CIK 0001909680 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,000

Underlying: Common Stock · 40,000 shares

Expires 2032-02-03

F1 · derivative.exercise_date: The shares underlying this option shall vest and become exercisable in forty-eight equal monthly installments over four years following the Grant Date, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0000899243-21-030774 · doc4.xml · nonDerivative · entry 2

Manning Paul B · CIK 0001494695 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 56,000

F3 · price: The price in Column 4 is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $6.855 to $7.80. Full information regarding the number of shares purchased at each separate price can be furnished to the SEC staff upon request.

F2 · ownership.direct: Shares held jointly with spouse.

SEC source: 0000899243-21-031104 · doc4.xml · derivative · entry 3

Martell Christopher · CIK 0001873465 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By GTAM1 2012 ADV LLC

Disclosed balance after: 0

Underlying: Common Stock · 283,514 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F1 · derivative.exercise_date: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F1 · derivative.expiration_date: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F2 · ownership.nature: Shares held by GTAM1 2012 ADV LLC, for which the Reporting Person serves as manager. The Reporting Person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein, if any.

SEC source: 0000899243-21-031104 · doc4.xml · nonDerivative · entry 2

Martell Christopher · CIK 0001873465 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By GTAM1 2012 LLC

Disclosed balance after: 125,000

F3 · ownership.nature: Shares held by GTAM1 2012 LLC, which is wholly owned by a trust for which the Reporting Person serves as trustee. The Reporting Person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein, if any.

SEC source: 0000899243-21-031104 · doc4.xml · nonDerivative · entry 1

Martell Christopher · CIK 0001873465 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By GTAM1 2012 ADV LLC

Disclosed balance after: 283,514

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F2 · ownership.nature: Shares held by GTAM1 2012 ADV LLC, for which the Reporting Person serves as manager. The Reporting Person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein, if any.

SEC source: 0000899243-21-031086 · doc4.xml · nonDerivative · entry 1

Caffo Nathan · CIK 0001816992 · Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 6,000

SEC source: 0000899243-21-031102 · doc4.xml · nonDerivative · entry 1

Nguyen Diem · CIK 0001814338 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,000

SEC source: 0000899243-21-031096 · doc4.xml · derivative · entry 5

Manning Paul B · CIK 0001494695 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By BKB Growth Investments, LLC

Disclosed balance after: 0

Underlying: Common Stock · 553,752 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F1 · derivative.exercise_date: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F1 · derivative.expiration_date: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F3 · ownership.nature: The shares are held directly by BKB Growth Investments, LLC ("BKB"). The Reporting Person is a co-manager of Tiger Lily Capital, LLC, the manager of BKB, and has shared voting and investment power with respect to the shares held by BKB. The Reporting Person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein.

SEC source: 0000899243-21-031096 · doc4.xml · derivative · entry 4

Manning Paul B · CIK 0001494695 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Paul B. Manning Revocable Trust

Disclosed balance after: 0

Underlying: Common Stock · 679,158 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F1 · derivative.exercise_date: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F1 · derivative.expiration_date: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F2 · ownership.nature: The shares are held by The Paul B. Manning Revocable Trust dated May 10, 2000 (the "Trust"). The Reporting Person is the trustee of the Trust and has sole voting and investment power with respect to the shares held by the Trust. The Reporting Person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein.

SEC source: 0000899243-21-031096 · doc4.xml · nonDerivative · entry 2

Manning Paul B · CIK 0001494695 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By BKB Growth Investments, LLC

Disclosed balance after: 553,752

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F3 · ownership.nature: The shares are held directly by BKB Growth Investments, LLC ("BKB"). The Reporting Person is a co-manager of Tiger Lily Capital, LLC, the manager of BKB, and has shared voting and investment power with respect to the shares held by BKB. The Reporting Person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein.

SEC source: 0000899243-21-031096 · doc4.xml · nonDerivative · entry 1

Manning Paul B · CIK 0001494695 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · By Paul B. Manning Revocable Trust

Disclosed balance after: 679,158

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F2 · ownership.nature: The shares are held by The Paul B. Manning Revocable Trust dated May 10, 2000 (the "Trust"). The Reporting Person is the trustee of the Trust and has sole voting and investment power with respect to the shares held by the Trust. The Reporting Person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein.

SEC source: 0000899243-21-031092 · doc4.xml · nonDerivative · entry 1

Canepa John J · CIK 0001589238 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,125

SEC source: 0000899243-21-031103 · doc4.xml · derivative · entry 3

Aguilar-Cordova Estuardo · CIK 0001873919 · Director · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 162,137 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F1 · derivative.exercise_date: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F1 · derivative.expiration_date: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F2 · ownership.direct: Includes 32,399 shares of common stock held jointly with spouse.

SEC source: 0000899243-21-031103 · doc4.xml · nonDerivative · entry 1

Aguilar-Cordova Estuardo · CIK 0001873919 · Director · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,015,923

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F2 · balance_after: Includes 32,399 shares of common stock held jointly with spouse.

F2 · ownership.direct: Includes 32,399 shares of common stock held jointly with spouse.

SEC source: 0000899243-21-031097 · doc4.xml · nonDerivative · entry 1

Tak Paul Peter · CIK 0001873905 · Director · Chief Executive Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 25,000

SEC source: 0000899243-21-031088 · doc4.xml · derivative · entry 3

Aguilar Laura K. · CIK 0001873915 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 56,096 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F1 · derivative.exercise_date: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F1 · derivative.expiration_date: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F2 · ownership.direct: Includes 32,399 shares of common stock held jointly with spouse.

SEC source: 0000899243-21-031088 · doc4.xml · nonDerivative · entry 1

Aguilar Laura K. · CIK 0001873915 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 931,039

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F2 · balance_after: Includes 32,399 shares of common stock held jointly with spouse.

F2 · ownership.direct: Includes 32,399 shares of common stock held jointly with spouse.

SEC source: 0000899243-21-031614 · doc4a.xml · derivative · entry 5

Manning Paul B · CIK 0001494695 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By BKB Growth Investments, LLC

Disclosed balance after: 0

Underlying: Common Stock · 553,752 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F1 · derivative.exercise_date: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F1 · derivative.expiration_date: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F3 · ownership.nature: The shares are held directly by BKB Growth Investments, LLC ("BKB"). The Reporting Person is a co-manager of Tiger Lily Capital, LLC, the manager of BKB, and has shared voting and investment power with respect to the shares held by BKB. The Reporting Person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein.

SEC source: 0000899243-21-031614 · doc4a.xml · derivative · entry 4

Manning Paul B · CIK 0001494695 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Paul B. Manning Revocable Trust

Disclosed balance after: 0

Underlying: Common Stock · 679,158 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F1 · derivative.exercise_date: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F1 · derivative.expiration_date: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F2 · ownership.nature: The shares are held by The Paul B. Manning Revocable Trust dated May 10, 2000 (the "Trust"). The Reporting Person is the trustee of the Trust and has sole voting and investment power with respect to the shares held by the Trust. The Reporting Person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein.

SEC source: 0000899243-21-031614 · doc4a.xml · nonDerivative · entry 3

Manning Paul B · CIK 0001494695 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 1,681,000

F4 · ownership.direct: Includes shares held jointly with spouse.

SEC source: 0000899243-21-031614 · doc4a.xml · nonDerivative · entry 2

Manning Paul B · CIK 0001494695 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By BKB Growth Investments, LLC

Disclosed balance after: 553,752

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F3 · ownership.nature: The shares are held directly by BKB Growth Investments, LLC ("BKB"). The Reporting Person is a co-manager of Tiger Lily Capital, LLC, the manager of BKB, and has shared voting and investment power with respect to the shares held by BKB. The Reporting Person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein.

SEC source: 0000899243-21-031614 · doc4a.xml · nonDerivative · entry 1

Manning Paul B · CIK 0001494695 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · By Paul B. Manning Revocable Trust

Disclosed balance after: 679,158

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: These shares of Series B Preferred Stock were convertible at any time at the holder's election and automatically converted on a one-for-2.4579 basis into shares of the Issuer's common stock immediately upon the closing of the Issuer's initial public offering ("IPO") without payment of additional consideration. The Series B Preferred Stock had no expiration date.

F2 · ownership.nature: The shares are held by The Paul B. Manning Revocable Trust dated May 10, 2000 (the "Trust"). The Reporting Person is the trustee of the Trust and has sole voting and investment power with respect to the shares held by the Trust. The Reporting Person disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein.

SEC source: 0000899243-21-030774 · doc4.xml · nonDerivative · entry 1

Manning Paul B · CIK 0001494695 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 36,000

F1 · price: The price in Column 4 is a weighted average price. The shares were purchased in multiple transactions at prices ranging from $7.31 to $7.40. Full information regarding the number of shares purchased at each separate price can be furnished to the SEC staff upon request.

F2 · ownership.direct: Shares held jointly with spouse.

SEC source: 0000899243-22-006188 · doc5.xml · derivative · entry 1

Nguyen Diem · CIK 0001814338 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,840

Underlying: Common Stock · 28,840 shares

Expires 2031-07-26

F1 · derivative.exercise_date: This option shall vest and become exercisable in thirty-six equal monthly installments following July 26, 2021, subject to the Reporting Person's continued service on each such vesting date.

SEC source: 0000899243-22-006325 · doc5a.xml · derivative · entry 1

Nguyen Diem · CIK 0001814338 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 28,480

Underlying: Common Stock · 28,480 shares

Expires 2031-07-26

F1 · derivative.exercise_date: This option shall vest and become exercisable in thirty-six equal monthly installments following July 26, 2021, subject to the Reporting Person's continued service on each such vesting date.