ARVN

SEC source: 0001655759-23-000067 · wk-form4_1687296513.xml · derivative · entry 2

Smaldone Alsup Laurie · CIK 0001589602 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,787

Underlying: Common Stock · 12,787 shares

Expires 2033-06-14

F2 · derivative.exercise_date: This option award was granted on June 15, 2023. The shares underlying the award shall vest in full on the earlier of June 15, 2024 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders.

SEC source: 0001655759-23-000067 · wk-form4_1687296513.xml · nonDerivative · entry 1

Smaldone Alsup Laurie · CIK 0001589602 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 4,121

F1 · shares: The restricted stock units (each, an "RSU") were granted by the Issuer on June 15, 2023 and each RSU represents a contingent right to receive one share of the Issuer's common stock upon settlement for no consideration. The RSUs shall vest in full on the earlier of June 15, 2024 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders.

SEC source: 0001655759-23-000059 · wk-form4_1687296305.xml · derivative · entry 2

AGARWAL SUNIL · CIK 0001616640 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,948

Underlying: Common Stock · 24,948 shares

Expires 2033-06-14

F2 · derivative.exercise_date: This option award was granted on June 15, 2023. The shares underlying the award shall vest over three years in equal monthly installments through June 15, 2026.

SEC source: 0001655759-23-000059 · wk-form4_1687296305.xml · nonDerivative · entry 1

AGARWAL SUNIL · CIK 0001616640 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 8,242

F1 · shares: The restricted stock units (each, an "RSU") were granted by the Issuer on June 15, 2023 and each RSU represents a contingent right to receive one share of the Issuer's common stock upon settlement for no consideration. The RSUs shall vest over three years in equal annual installments through June 15, 2026.

SEC source: 0001655759-23-000065 · wk-form4_1687296466.xml · derivative · entry 2

Morrison Briggs · CIK 0001654430 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 12,787

Underlying: Common Stock · 12,787 shares

Expires 2033-06-14

F2 · derivative.exercise_date: This option award was granted on June 15, 2023. The shares underlying the award shall vest in full on the earlier of June 15, 2024 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders.

SEC source: 0001655759-23-000065 · wk-form4_1687296466.xml · nonDerivative · entry 1

Morrison Briggs · CIK 0001654430 · Director

10b5-1 filing: No plan indicated

Ownership: Direct

Disclosed balance after: 24,097

F1 · shares: The restricted stock units (each, an "RSU") were granted by the Issuer on June 15, 2023 and each RSU represents a contingent right to receive one share of the Issuer's common stock upon settlement for no consideration. The RSUs shall vest in full on the earlier of June 15, 2024 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders.

SEC source: 0001655759-23-000026 · wf-form4_167789825591082.xml · derivative · entry 3

Taylor Ian · CIK 0001753281 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 2,685 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of the Issuer's common stock.

F4 · derivative.exercise_date: On March 1, 2019, the reporting person was granted 10,742 Restricted Stock Units, vesting in four equal annual installments beginning March 1, 2020.

F4 · derivative.expiration_date: On March 1, 2019, the reporting person was granted 10,742 Restricted Stock Units, vesting in four equal annual installments beginning March 1, 2020.

SEC source: 0001655759-23-000026 · wf-form4_167789825591082.xml · nonDerivative · entry 2

Taylor Ian · CIK 0001753281 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 101,721

F2 · shares: This sale was made to cover withholding taxes following the vesting of previously granted Restricted Stock Units.

F3 · price: The broker sold shares of the Issuer's common stock for certain employees following the vesting of previously granted Restricted Stock Units, including the common stock reported on this Form 4 by the reporting person, at a price of $29.53.

SEC source: 0001655759-23-000026 · wf-form4_167789825591082.xml · nonDerivative · entry 1

Taylor Ian · CIK 0001753281 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 102,772

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each Restricted Stock Unit represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001655759-23-000024 · wf-form4_167789814910051.xml · derivative · entry 3

Cassidy Sean A · CIK 0001421914 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 4,791 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of the Issuer's common stock.

F4 · derivative.exercise_date: On March 1, 2019, the reporting person was granted 19,165 Restricted Stock Units, vesting in four equal annual installments beginning March 1, 2020.

F4 · derivative.expiration_date: On March 1, 2019, the reporting person was granted 19,165 Restricted Stock Units, vesting in four equal annual installments beginning March 1, 2020.

SEC source: 0001655759-23-000024 · wf-form4_167789814910051.xml · nonDerivative · entry 2

Cassidy Sean A · CIK 0001421914 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 183,618

F2 · shares: This sale was made to cover withholding taxes following the vesting of previously granted Restricted Stock Units.

F3 · price: The broker sold shares of the Issuer's common stock for certain employees following the vesting of previously granted Restricted Stock Units, including the common stock reported on this Form 4 by the reporting person, at a price of $29.53.

SEC source: 0001655759-23-000024 · wf-form4_167789814910051.xml · nonDerivative · entry 1

Cassidy Sean A · CIK 0001421914 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 185,363

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each Restricted Stock Unit represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001655759-23-000025 · wf-form4_167789819786057.xml · derivative · entry 3

Houston John G · CIK 0001753537 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 17,510 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of the Issuer's common stock.

F4 · derivative.exercise_date: On March 1, 2019, the reporting person was granted 70,042 Restricted Stock Units, vesting in four equal annual installments beginning March 1, 2020.

F4 · derivative.expiration_date: On March 1, 2019, the reporting person was granted 70,042 Restricted Stock Units, vesting in four equal annual installments beginning March 1, 2020.

SEC source: 0001655759-23-000025 · wf-form4_167789819786057.xml · nonDerivative · entry 2

Houston John G · CIK 0001753537 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 917,427

F2 · shares: This sale was made to cover withholding taxes following the vesting of previously granted Restricted Stock Units.

F3 · price: The broker sold shares of the Issuer's common stock for certain employees following the vesting of previously granted Restricted Stock Units, including the common stock reported on this Form 4 by the reporting person, at a price of $29.53.

SEC source: 0001655759-23-000025 · wf-form4_167789819786057.xml · nonDerivative · entry 1

Houston John G · CIK 0001753537 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 923,305

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each Restricted Stock Unit represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001655759-23-000017 · wf-form4_167727578035848.xml · derivative · entry 2

Taylor Ian · CIK 0001753281 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 57,450

Underlying: Common Stock · 57,450 shares

Expires 2033-02-21

F2 · derivative.exercise_date: The option was granted by the Issuer on February 22, 2023, pursuant to the Plan. The shares underlying the option will vest over four years: 1/4 of the shares underlying the award shall vest on February 22, 2024, with the remainder of the shares vesting in equal monthly installments following February 22, 2024 through February 23, 2027.

SEC source: 0001655759-23-000017 · wf-form4_167727578035848.xml · nonDerivative · entry 1

Taylor Ian · CIK 0001753281 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,087

F1 · shares: The restricted stock units (each, an "RSU") were granted by the Issuer on February 22, 2023, pursuant to its 2018 Stock Incentive Plan (the "Plan") and each RSU represents a contingent right to receive one share of the Issuer's common stock upon settlement for no consideration. The RSUs will vest over four years: 1/4 of the shares underlying the award shall vest on February 22, 2024, with the remainder of the shares vesting in equal monthly installments following February 22, 2024 through February 23, 2027.

SEC source: 0001655759-23-000020 · wf-form4_167727595596926.xml · derivative · entry 2

Cassidy Sean A · CIK 0001421914 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 57,450

Underlying: Common Stock · 57,450 shares

Expires 2033-02-21

F2 · derivative.exercise_date: The option was granted by the Issuer on February 22, 2023, pursuant to the Plan. The shares underlying the option will vest over four years: 1/4 of the shares underlying the award shall vest on February 22, 2024, with the remainder of the shares vesting in equal monthly installments following February 22, 2024 through February 23, 2027.

SEC source: 0001655759-23-000020 · wf-form4_167727595596926.xml · nonDerivative · entry 1

Cassidy Sean A · CIK 0001421914 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 180,572

F1 · shares: The restricted stock units (each, an "RSU") were granted by the Issuer on February 22, 2023, pursuant to its 2018 Stock Incentive Plan (the "Plan") and each RSU represents a contingent right to receive one share of the Issuer's common stock upon settlement for no consideration. The RSUs will vest over four years: 1/4 of the shares underlying the award shall vest on February 22, 2024, with the remainder of the shares vesting in equal monthly installments following February 22, 2024 through February 23, 2027.

SEC source: 0001655759-23-000019 · wf-form4_167727589261851.xml · derivative · entry 2

Peck Ronald · CIK 0001783868 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 57,450

Underlying: Common Stock · 57,450 shares

Expires 2033-02-21

F2 · derivative.exercise_date: The option was granted by the Issuer on February 22, 2023, pursuant to the Plan. The shares underlying the option will vest over four years: 1/4 of the shares underlying the award shall vest on February 22, 2024, with the remainder of the shares vesting in equal monthly installments following February 22, 2024 through February 23, 2027.

SEC source: 0001655759-23-000019 · wf-form4_167727589261851.xml · nonDerivative · entry 1

Peck Ronald · CIK 0001783868 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,279

F1 · shares: The restricted stock units (each, an "RSU") were granted by the Issuer on February 22, 2023, pursuant to its 2018 Stock Incentive Plan (the "Plan") and each RSU represents a contingent right to receive one share of the Issuer's common stock upon settlement for no consideration. The RSUs will vest over four years: 1/4 of the shares underlying the award shall vest on February 22, 2024, with the remainder of the shares vesting in equal monthly installments following February 22, 2024 through February 23, 2027.

SEC source: 0001655759-23-000018 · wf-form4_167727583617856.xml · derivative · entry 2

Houston John G · CIK 0001753537 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 186,250

Underlying: Common Stock · 186,250 shares

Expires 2033-02-21

F2 · derivative.exercise_date: The option was granted by the Issuer on February 22, 2023, pursuant to the Plan. The shares underlying the option will vest over four years: 1/4 of the shares underlying the award shall vest on February 22, 2024, with the remainder of the shares vesting in equal monthly installments following February 22, 2024 through February 23, 2027.

SEC source: 0001655759-23-000018 · wf-form4_167727583617856.xml · nonDerivative · entry 1

Houston John G · CIK 0001753537 · Director · President and CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 905,795

F1 · shares: The restricted stock units (each, an "RSU") were granted by the Issuer on February 22, 2023, pursuant to its 2018 Stock Incentive Plan (the "Plan") and each RSU represents a contingent right to receive one share of the Issuer's common stock upon settlement for no consideration. The RSUs will vest over four years: 1/4 of the shares underlying the award shall vest on February 22, 2024, with the remainder of the shares vesting in equal monthly installments following February 22, 2024 through February 23, 2027.

SEC source: 0001655759-22-000077 · wf-form4_167148884711783.xml · derivative · entry 1

Cunningham Everett · CIK 0001564777 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,095

Underlying: Common Stock · 30,095 shares

Expires 2032-12-14

F1 · derivative.exercise_date: This option award was granted on December 15, 2022. The shares underlying the award shall vest in equal monthly installments through December 14, 2025.

SEC source: 0001655759-22-000042 · wf-form4_166120212293775.xml · derivative · entry 1

YOUNG JOHN D · CIK 0001551792 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,572

Underlying: Common Stock · 24,572 shares

Expires 2032-08-17

F1 · derivative.exercise_date: This option award was granted on August 18, 2022. The shares underlying the award shall vest in equal monthly installments through August 18, 2025.

SEC source: 0001655759-22-000034 · wf-form4a_166068510249537.xml · derivative · entry 3

Peck Ronald · CIK 0001783868 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,010

Underlying: Common Stock · 4,010 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of the Issuer's common stock.

F4 · derivative.exercise_date: On July 29, 2019, the reporting person was granted 16,041 Restricted Stock Units, vesting in four equal annual installments beginning July 29, 2020.

F4 · derivative.expiration_date: On July 29, 2019, the reporting person was granted 16,041 Restricted Stock Units, vesting in four equal annual installments beginning July 29, 2020.

SEC source: 0001655759-22-000034 · wf-form4a_166068510249537.xml · nonDerivative · entry 2

Peck Ronald · CIK 0001783868 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,154

F2 · shares: This sale was made to cover withholding taxes following the vesting of previously granted Restricted Stock Units.

F3 · price: This amendment is being filed to correct the sales price reported on the reporting person's Form 4 filed on August 16, 2022.

SEC source: 0001655759-22-000034 · wf-form4a_166068510249537.xml · nonDerivative · entry 1

Peck Ronald · CIK 0001783868 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,412

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each Restricted Stock Unit represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001655759-22-000032 · wf-form4_166068253320788.xml · derivative · entry 3

Peck Ronald · CIK 0001783868 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 4,010

Underlying: Common Stock · 4,010 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of the Issuer's common stock.

F3 · derivative.exercise_date: On July 29, 2019, the reporting person was granted 16,041 Restricted Stock Units, vesting in four equal annual installments beginning July 29, 2020.

F3 · derivative.expiration_date: On July 29, 2019, the reporting person was granted 16,041 Restricted Stock Units, vesting in four equal annual installments beginning July 29, 2020.

SEC source: 0001655759-22-000032 · wf-form4_166068253320788.xml · nonDerivative · entry 2

Peck Ronald · CIK 0001783868 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 8,154

F2 · shares: This sale was made to cover withholding taxes following the vesting of previously granted Restricted Stock Units.

SEC source: 0001655759-22-000032 · wf-form4_166068253320788.xml · nonDerivative · entry 1

Peck Ronald · CIK 0001783868 · Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 9,412

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · price: Each Restricted Stock Unit represents a contingent right to receive one share of the Issuer's common stock.

SEC source: 0001209191-22-038557 · doc4.xml · derivative · entry 1

Kennedy Edward Moore Jr. · CIK 0001753859 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,192

Underlying: Common Stock · 10,192 shares

Expires 2032-06-15

F1 · derivative.exercise_date: This option award was granted on June 16, 2022. The shares underlying the award shall vest in full on the earlier of June 16, 2023 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders.

SEC source: 0001209191-22-038559 · doc4.xml · derivative · entry 1

SHANNON TIMOTHY M · CIK 0001207114 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,192

Underlying: Common Stock · 10,192 shares

Expires 2032-06-15

F1 · derivative.exercise_date: This option award was granted on June 16, 2022. The shares underlying the award shall vest in full on the earlier of June 16, 2023 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders.

SEC source: 0001209191-22-038560 · doc4.xml · derivative · entry 1

DIXON WENDY L · CIK 0001202283 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,192

Underlying: Common Stock · 10,192 shares

Expires 2032-06-15

F1 · derivative.exercise_date: This option award was granted on June 16, 2022. The shares underlying the award shall vest in full on the earlier of June 16, 2023 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders.

SEC source: 0001209191-22-038552 · doc4.xml · derivative · entry 1

Norwalk Leslie V · CIK 0001533568 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,192

Underlying: Common Stock · 10,192 shares

Expires 2032-06-15

F1 · derivative.exercise_date: This option award was granted on June 16, 2022. The shares underlying the award shall vest in full on the earlier of June 16, 2023 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders.

SEC source: 0001209191-22-038558 · doc4.xml · derivative · entry 1

Ratcliffe Liam · CIK 0001547100 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,192

Underlying: Common Stock · 10,192 shares

Expires 2032-06-15

F1 · derivative.exercise_date: This option award was granted on June 16, 2022. The shares underlying the award shall vest in full on the earlier of June 16, 2023 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders.

SEC source: 0001209191-22-038555 · doc4.xml · derivative · entry 1

Bain Linda · CIK 0001578407 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,192

Underlying: Common Stock · 10,192 shares

Expires 2032-06-15

F1 · derivative.exercise_date: This option award was granted on June 16, 2022. The shares underlying the award shall vest in full on the earlier of June 16, 2023 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders.

SEC source: 0001209191-22-038556 · doc4.xml · derivative · entry 1

Smaldone Alsup Laurie · CIK 0001589602 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,192

Underlying: Common Stock · 10,192 shares

Expires 2032-06-15

F1 · derivative.exercise_date: This option award was granted on June 16, 2022. The shares underlying the award shall vest in full on the earlier of June 16, 2023 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders.

SEC source: 0001209191-22-038553 · doc4.xml · derivative · entry 1

Morrison Briggs · CIK 0001654430 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,192

Underlying: Common Stock · 10,192 shares

Expires 2032-06-15

F1 · derivative.exercise_date: This option award was granted on June 16, 2022. The shares underlying the award shall vest in full on the earlier of June 16, 2023 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders.

SEC source: 0001209191-22-038554 · doc4.xml · derivative · entry 1

Margus Bradley Albert · CIK 0001753491 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,192

Underlying: Common Stock · 10,192 shares

Expires 2032-06-15

F1 · derivative.exercise_date: This option award was granted on June 16, 2022. The shares underlying the award shall vest in full on the earlier of June 16, 2023 or the first meeting of the board of directors of the Issuer held after the following annual meeting of stockholders.

SEC source: 0001209191-22-024674 · doc4.xml · derivative · entry 5

Morrison Briggs · CIK 0001654430 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 494

Underlying: Common Stock · 16,188 shares

Expires 2028-09-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercises and sales reported on this form were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 16, 2021.

F5 · derivative.exercise_date: This option award was granted on September 26, 2018. 1/12 of the shares underlying the award vested as of June 28, 2018, with the remainder of the shares vesting in equal quarterly installments following June 28, 2018 through March 28, 2021.

SEC source: 0001209191-22-024674 · doc4.xml · nonDerivative · entry 4

Morrison Briggs · CIK 0001654430 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 19,976

F1 · kind: The exercises and sales reported on this form were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 16, 2021.

F4 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $66.58 to $67.40, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the Staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within such range.

SEC source: 0001209191-22-024674 · doc4.xml · nonDerivative · entry 3

Morrison Briggs · CIK 0001654430 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 30,730

F1 · kind: The exercises and sales reported on this form were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 16, 2021.

F3 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $65.56 to $66.54, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the Staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within such range.

SEC source: 0001209191-22-024674 · doc4.xml · nonDerivative · entry 2

Morrison Briggs · CIK 0001654430 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,834

F1 · kind: The exercises and sales reported on this form were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 16, 2021.

F2 · price: The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $64.55 to $65.54, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer or the Staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within such range.

SEC source: 0001209191-22-024674 · doc4.xml · nonDerivative · entry 1

Morrison Briggs · CIK 0001654430 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 40,936

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The exercises and sales reported on this form were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on December 16, 2021.

SEC source: 0001209191-22-022103 · doc4.xml · nonDerivative · entry 1

Taylor Ian · CIK 0001753281 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 80,962

F1 · kind: Reflects the gift of common stock to a charitable donor advised fund.

SEC source: 0001209191-22-018995 · doc4.xml · derivative · entry 3

Cassidy Sean A · CIK 0001421914 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 16,710

Underlying: Common Stock · 15,000 shares

Expires 2028-09-25

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The stock option exercise reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 8, 2021.

F3 · derivative.exercise_date: This option award was granted on September 26, 2018, and the shares underlying the award were fully vested upon grant.

SEC source: 0001209191-22-018995 · doc4.xml · nonDerivative · entry 2

Cassidy Sean A · CIK 0001421914 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 161,447

F2 · kind: The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 8, 2021.

SEC source: 0001209191-22-018995 · doc4.xml · nonDerivative · entry 1

Cassidy Sean A · CIK 0001421914 · Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 176,447

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · kind: The stock option exercise reported in this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on November 8, 2021.

SEC source: 0001209191-22-016532 · doc4.xml · derivative · entry 4

Taylor Ian · CIK 0001753281 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 2,685

Underlying: Common Stock · 2,686 shares

Expires not disclosed

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_price: Each Restricted Stock Unit represents a contingent right to receive one share of the Issuer's common stock.

F5 · derivative.exercise_date: On March 1, 2019, the reporting person was granted 10,742 Restricted Stock Units, vesting in four equal annual installments beginning March 1, 2020.

F5 · derivative.expiration_date: On March 1, 2019, the reporting person was granted 10,742 Restricted Stock Units, vesting in four equal annual installments beginning March 1, 2020.