ANNX

SEC source: 0001567619-23-003424 · doc1.xml · derivative · entry 2

Lew Jennifer · CIK 0001465994 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 77,050

Underlying: Common Stock · 77,050 shares

Expires 2033-02-16

F3 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from February 16, 2023 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date.

SEC source: 0001567619-23-003424 · doc1.xml · nonDerivative · entry 1

Lew Jennifer · CIK 0001465994 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 48,517

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on February 16 of each year, with the first 1/3rd vesting on February 16, 2024.

F2 · balance_after: Includes 36,684 RSUs.

SEC source: 0001567619-23-003317 · doc1.xml · nonDerivative · entry 1

Love Douglas · CIK 0001818520 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 197,646

F1 · kind: The shares were sold to cover tax withholding obligations in connection with the vesting of restricted stock units.

F2 · price: This transaction was executed in multiple trades in prices ranging from $5.80 to $5.95, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F3 · balance_after: Includes 3,274 shares acquired on May 15, 2022 and 1 share acquired on November 15, 2022, pursuant to the Issuer's Employee Stock Purchase Plan.

F4 · balance_after: Includes 26,667 restricted stock units.

SEC source: 0001567619-23-003095 · doc1.xml · nonDerivative · entry 2

Overdorf Michael · CIK 0001818522 · EVP & Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,805

F1 · kind: The shares were sold to cover tax withholding obligations in connection with the vesting of restricted stock units.

F4 · balance_after: Includes 17,709 restricted stock units.

SEC source: 0001567619-23-003094 · doc1.xml · nonDerivative · entry 2

Lew Jennifer · CIK 0001465994 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,542

F1 · kind: The shares were sold to cover tax withholding obligations in connection with the vesting of restricted stock units.

F4 · balance_after: Includes 17,709 restricted stock units.

SEC source: 0001567619-23-003095 · doc1.xml · nonDerivative · entry 1

Overdorf Michael · CIK 0001818522 · EVP & Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 27,949

F1 · kind: The shares were sold to cover tax withholding obligations in connection with the vesting of restricted stock units.

F2 · price: This transaction was executed in multiple trades in prices ranging from $6.15 to $6.43, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F3 · balance_after: Includes 7,575 shares acquired pursuant to the Issuer's Employee Stock Purchase Plan on November 15, 2022.

F4 · balance_after: Includes 17,709 restricted stock units.

SEC source: 0001567619-23-003094 · doc1.xml · nonDerivative · entry 1

Lew Jennifer · CIK 0001465994 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 29,708

F1 · kind: The shares were sold to cover tax withholding obligations in connection with the vesting of restricted stock units.

F2 · price: This transaction was executed in multiple trades in prices ranging from $6.15 to $6.43, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

F3 · balance_after: Includes 7,575 shares acquired pursuant to the Issuer's Employee Stock Purchase Plan on November 15, 2022.

F4 · balance_after: Includes 17,709 restricted stock units.

SEC source: 0001567619-23-002932 · doc1.xml · nonDerivative · entry 1

Satter Muneer A · CIK 0001315797 · Director · 10% owner

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 7,056,024

F1 · shares: All shares were purchased by Alerce Medical Technology Partners, L.P. ("Alerce Medical") for which the Reporting Person has sole voting and dispositive power over all such shares. The Reporting Person disclaims beneficial ownership of the shares except to the extent of his pecuniary interest therein.

F2 · ownership.nature: Includes (a) 240,000 shares that are held by the Muneer A. Satter Revocable Trust for which the Reporting Person serves as trustee and, in such capacity, has sole voting and dispositive power over all such shares, (b) 567,240 shares that are held by various other trusts and other entities for which the Reporting Person serves as trustee, investment advisor or manager and, in such capacity, has sole voting and dispositive power over all such shares, (c) 1,147,738 shares that are held by Satter Medical Technology Partners, L.P. for which the Reporting Person has sole voting and dispositive power over all such shares and (d) 5,101,046 shares that are held by Alerce Medical for which the Reporting Person has sole voting and dispositive power of all such shares. The Reporting Person disclaims beneficial ownership of all shares included under (b), (c) and (d) of this footnote, except to the extent of his pecuniary interest.

SEC source: 0001567619-23-000998 · doc1.xml · derivative · entry 1

ARTIS DEAN RICHARD · CIK 0001958523 · EVP & Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 210,000

Underlying: Common Stock · 210,000 shares

Expires 2033-01-15

F1 · derivative.exercise_date: 25% of the shares subject to the option vest on the first anniversary measured from January 6, 2023 (the "Vesting Commencement Date"), and 1/48th of the total number of shares vest monthly thereafter, such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date.

SEC source: 0001567619-22-013999 · doc1.xml · derivative · entry 2

Overdorf Michael · CIK 0001818522 · EVP & Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2032-07-11

F3 · derivative.exercise_date: 1/36th of the shares subject to the option vest on each monthly anniversary measured from July 11, 2022 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the third anniversary of the Vesting Commencement Date.

SEC source: 0001567619-22-013999 · doc1.xml · nonDerivative · entry 1

Overdorf Michael · CIK 0001818522 · EVP & Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 21,875

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on July 11th of each year, with the first 1/3rd vesting on July 11, 2023.

F2 · balance_after: Includes 21,875 RSUs.

SEC source: 0001567619-22-013998 · doc1.xml · derivative · entry 1

Love Douglas · CIK 0001818520 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 300,000

Underlying: Common Stock · 300,000 shares

Expires 2032-07-11

F1 · derivative.exercise_date: 1/36th of the shares subject to the option vest on each monthly anniversary measured from July 11, 2022 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the third anniversary of the Vesting Commencement Date.

SEC source: 0001567619-22-013994 · doc1.xml · derivative · entry 1

Love Douglas · CIK 0001818520 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 300,000

Underlying: Common Stock · 300,000 shares

Expires 2032-07-11

F1 · derivative.exercise_date: 1/36th of the shares subject to the option vest on each monthly anniversary measured from July 11, 2022 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the third anniversary of the Vesting Commencement Date.

SEC source: 0001567619-22-013992 · doc1.xml · derivative · entry 1

Love Douglas · CIK 0001818520 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 300,000

Underlying: Common Stock · 300,000 shares

Expires 2032-07-11

F1 · derivative.exercise_date: 1/36th of the shares subject to the option vest on each monthly anniversary measured from July 11, 2022 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the third anniversary of the Vesting Commencement Date.

SEC source: 0001567619-22-013991 · doc1.xml · derivative · entry 2

Lew Jennifer · CIK 0001465994 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 75,000

Underlying: Common Stock · 75,000 shares

Expires 2032-07-11

F3 · derivative.exercise_date: 1/36th of the shares subject to the option vest on each monthly anniversary measured from July 11, 2022 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the third anniversary of the Vesting Commencement Date.

SEC source: 0001567619-22-013991 · doc1.xml · nonDerivative · entry 1

Lew Jennifer · CIK 0001465994 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 23,875

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on July 11th of each year, with the first 1/3rd vesting on July 11, 2023.

F2 · balance_after: Includes 21,875 RSUs.

SEC source: 0001567619-22-013997 · doc1.xml · derivative · entry 2

Mattheakis Larry · CIK 0001885081 · EVP & Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,500

Underlying: Common Stock · 37,500 shares

Expires 2032-07-11

F3 · derivative.exercise_date: 1/36th of the shares subject to the option vest on each monthly anniversary measured from July 11, 2022 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the third anniversary of the Vesting Commencement Date.

SEC source: 0001567619-22-013997 · doc1.xml · nonDerivative · entry 1

Mattheakis Larry · CIK 0001885081 · EVP & Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,188

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on July 11th of each year, with the first 1/3rd vesting on July 11, 2023.

F2 · balance_after: Includes 17,188 RSUs.

SEC source: 0001567619-22-013996 · doc1.xml · derivative · entry 2

Mattheakis Larry · CIK 0001885081 · EVP & Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,500

Underlying: Common Stock · 37,500 shares

Expires 2032-07-11

F3 · derivative.exercise_date: 1/36th of the shares subject to the option vest on each monthly anniversary measured from July 11, 2022 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the third anniversary of the Vesting Commencement Date.

SEC source: 0001567619-22-013996 · doc1.xml · nonDerivative · entry 1

Mattheakis Larry · CIK 0001885081 · EVP & Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 17,188

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on July 11th of each year, with the first 1/3rd vesting on July 11, 2023.

F2 · balance_after: Includes 17,188 RSUs.

SEC source: 0001567619-22-013890 · doc1.xml · derivative · entry 2

Satter Muneer A · CIK 0001315797 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 613,497

Underlying: Common Stock · 613,497 shares

Expires 2025-06-30

F3 · ownership.nature: The warrants are held by SMTP II for which the Reporting Person has sole voting and dispositive power of all such warrants. The Reporting Person disclaims beneficial ownership of all the warrants, except to the extent of his pecuniary interest.

SEC source: 0001567619-22-013890 · doc1.xml · nonDerivative · entry 1

Satter Muneer A · CIK 0001315797 · Director

10b5-1 filing: Not disclosed

Ownership: Indirect · See footnote

Disclosed balance after: 4,408,966

F1 · shares: Reflects shares that were purchased from the Issuer on July 7, 2022 in a private offering pursuant to a Securities Purchase Agreement, dated July 7, 2022. The shares were purchased by Satter Medical Technology Partners II, L.P. ("SMTP II") for which the Reporting Person has sole voting and dispositive power over all such shares. The Reporting Person disclaims beneficial ownership of the shares except to the extent of his pecuniary interest therein.

F2 · ownership.nature: Includes (a) 240,000 shares that are held by the Muneer A. Satter Revocable Trust for which the Reporting Person serves as trustee and, in such capacity, has sole voting and dispositive power over all such shares, (b) 567,240 shares that are held by various other trusts and other entities for which the Reporting Person serves as trustee, investment advisor or manager and, in such capacity, has sole voting and dispositive power over all such shares, (c) 1,147,738 shares that are held by Satter Medical Technology Partners, L.P. for which the Reporting Person has sole voting and dispositive power over all such shares and (d) 2,453,988 shares that are held by SMTP II for which the Reporting Person has sole voting and dispositive power of all such shares. The Reporting Person disclaims beneficial ownership of all shares included under (b), (c) and (d) of this footnote, except to the extent of his pecuniary interest.

SEC source: 0001567619-22-012781 · doc1.xml · derivative · entry 1

WIGGANS THOMAS G · CIK 0001208907 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,000

Underlying: Common Stock · 24,000 shares

Expires 2032-06-09

F1 · derivative.exercise_date: The underlying shares subject to the option vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of (i) the first anniversary of June 9, 2022 or (ii) the next Annual Meeting following June 9, 2022, subject to Reporting Person's continuous service as a director until such vesting date.

SEC source: 0001567619-22-012779 · doc1.xml · derivative · entry 1

Satter Muneer A · CIK 0001315797 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,000

Underlying: Common Stock · 24,000 shares

Expires 2032-06-09

F1 · derivative.exercise_date: The underlying shares subject to the option vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of (i) the first anniversary of June 9, 2022 or (ii) the next Annual Meeting following June 9, 2022, subject to Reporting Person's continuous service as a director until such vesting date.

SEC source: 0001567619-22-012775 · doc1.xml · derivative · entry 1

Choi Jung · CIK 0001650126 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,000

Underlying: Common Stock · 24,000 shares

Expires 2032-06-09

F1 · derivative.exercise_date: The underlying shares subject to the option vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of (i) the first anniversary of June 9, 2022 or (ii) the next Annual Meeting following June 9, 2022, subject to Reporting Person's continuous service as a director until such vesting date.

SEC source: 0001567619-22-012780 · doc1.xml · derivative · entry 1

Waddill William D. · CIK 0001553338 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,000

Underlying: Common Stock · 24,000 shares

Expires 2032-06-09

F1 · derivative.exercise_date: The underlying shares subject to the option vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of (i) the first anniversary of June 9, 2022 or (ii) the next Annual Meeting following June 9, 2022, subject to Reporting Person's continuous service as a director until such vesting date.

SEC source: 0001567619-22-012777 · doc1.xml · derivative · entry 1

Cockroft Bettina M. · CIK 0001900452 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,000

Underlying: Common Stock · 24,000 shares

Expires 2032-06-09

F1 · derivative.exercise_date: The underlying shares subject to the option vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of (i) the first anniversary of June 9, 2022 or (ii) the next Annual Meeting following June 9, 2022, subject to Reporting Person's continuous service as a director until such vesting date.

SEC source: 0001567619-22-012774 · doc1.xml · derivative · entry 1

Carson William H. · CIK 0001824280 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 24,000

Underlying: Common Stock · 24,000 shares

Expires 2032-06-09

F1 · derivative.exercise_date: The underlying shares subject to the option vest and become exercisable as to 100% of the total number of shares subject to the option on the earlier of (i) the first anniversary of June 9, 2022 or (ii) the next Annual Meeting following June 9, 2022, subject to Reporting Person's continuous service as a director until such vesting date.

SEC source: 0001567619-22-008630 · doc1.xml · nonDerivative · entry 1

Love Douglas · CIK 0001818520 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 200,942

F1 · price: The shares were purchased in multiple transactions at prices ranging from $2.41 to $2.50, inclusive. The price reported in Column 4 above reflects the weighted average purchase price. The reporting person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares purchased at each respective price within the range set forth in this footnote.

F2 · balance_after: Includes 160,942 shares held and 40,000 restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting.

SEC source: 0001567619-22-004614 · doc1.xml · derivative · entry 2

Overdorf Michael · CIK 0001818522 · EVP & Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2032-02-11

F3 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from February 11, 2022 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date.

SEC source: 0001567619-22-004614 · doc1.xml · nonDerivative · entry 1

Overdorf Michael · CIK 0001818522 · EVP & Chief Business Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,500

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on February 11 of each year, with the first 1/3rd vesting on February 11, 2023.

F2 · balance_after: Includes 12,500 RSUs.

SEC source: 0001567619-22-004615 · doc1.xml · derivative · entry 2

Love Douglas · CIK 0001818520 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 320,000

Underlying: Common Stock · 320,000 shares

Expires 2032-02-11

F3 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from February 11, 2022 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date.

SEC source: 0001567619-22-004615 · doc1.xml · nonDerivative · entry 1

Love Douglas · CIK 0001818520 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 140,942

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on February 11 of each year, with the first 1/3rd vesting on February 11, 2023.

F2 · balance_after: Includes 40,000 RSUs.

SEC source: 0001567619-22-004613 · doc1.xml · derivative · entry 2

Keswani Sanjay · CIK 0001818524 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2032-02-11

F3 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from February 11, 2022 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date.

SEC source: 0001567619-22-004613 · doc1.xml · nonDerivative · entry 1

Keswani Sanjay · CIK 0001818524 · EVP & Chief Medical Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,500

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on February 11 of each year, with the first 1/3rd vesting on February 11, 2023.

F2 · balance_after: Includes 12,500 RSUs.

SEC source: 0001567619-22-004612 · doc1.xml · derivative · entry 2

Lew Jennifer · CIK 0001465994 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2032-02-11

F3 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from February 11, 2022 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date.

SEC source: 0001567619-22-004612 · doc1.xml · nonDerivative · entry 1

Lew Jennifer · CIK 0001465994 · EVP & Chief Financial Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 14,500

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on February 11 of each year, with the first 1/3rd vesting on February 11, 2023.

F2 · balance_after: Includes 12,500 RSUs.

SEC source: 0001567619-22-004611 · doc1.xml · derivative · entry 2

Mattheakis Larry · CIK 0001885081 · EVP & Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,000

Underlying: Common Stock · 100,000 shares

Expires 2032-02-11

F3 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from February 11, 2022 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date.

SEC source: 0001567619-22-004611 · doc1.xml · nonDerivative · entry 1

Mattheakis Larry · CIK 0001885081 · EVP & Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 12,500

F1 · shares: Constitute restricted stock units ("RSUs") for which the Reporting Person is entitled to receive one (1) share of Common Stock for each RSU upon vesting. 1/3rd of the RSUs vest annually on February 11 of each year, with the first 1/3rd vesting on February 11, 2023.

F2 · balance_after: Includes 12,500 RSUs.

SEC source: 0001567619-22-001370 · doc1.xml · derivative · entry 1

Cockroft Bettina M. · CIK 0001900452 · Director

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 20,000

Underlying: Common Stock · 20,000 shares

Expires 2032-01-19

F1 · derivative.exercise_date: 1/36th of the shares subject to the option vest on each monthly anniversary measured from January 19, 2022 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the third anniversary of the Vesting Commencement Date.

SEC source: 0001567619-21-020520 · doc1.xml · derivative · entry 4

Love Douglas · CIK 0001818520 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 114,449

Underlying: Common Stock · 30,000 shares

Expires 2026-08-11

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The shares subject to the option are fully vested and exercisable.

SEC source: 0001567619-21-020520 · doc1.xml · derivative · entry 3

Love Douglas · CIK 0001818520 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

Underlying: Common Stock · 70,942 shares

Expires 2025-01-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F1 · derivative.exercise_date: The shares subject to the option are fully vested and exercisable.

SEC source: 0001567619-21-020520 · doc1.xml · nonDerivative · entry 2

Love Douglas · CIK 0001818520 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 100,942

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-21-020520 · doc1.xml · nonDerivative · entry 1

Love Douglas · CIK 0001818520 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 70,942

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-21-017862 · doc1.xml · derivative · entry 1

Mattheakis Larry · CIK 0001885081 · Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 220,000

Underlying: Common Stock · 220,000 shares

Expires 2031-09-30

F1 · derivative.exercise_date: 25% of the shares subject to the option vest on the first anniversary measured from September 30, 2021 (the "Vesting Commencement Date"), and 1/48th of the total number of shares vest monthly thereafter, such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date.

SEC source: 0001567619-21-017366 · doc1.xml · derivative · entry 3

Love Douglas · CIK 0001818520 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 37,994

Underlying: Common Stock · 7,500 shares

Expires 2025-01-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The shares subject to the option are fully vested and exercisable.

SEC source: 0001567619-21-017366 · doc1.xml · nonDerivative · entry 2

Love Douglas · CIK 0001818520 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 0

F1 · kind: The transactions reported herein were effected pursuant to the Reporting Person's Rule 10b5-1 trading plan.

F2 · price: This transaction was executed in multiple trades in prices ranging from $22.00 to $22.26, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote.

SEC source: 0001567619-21-017366 · doc1.xml · nonDerivative · entry 1

Love Douglas · CIK 0001818520 · Director · President & CEO

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 7,500

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

SEC source: 0001567619-21-017166 · doc1.xml · derivative · entry 5

Yednock Ted · CIK 0001818525 · EVP & Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 67,939

Underlying: Common Stock · 1,190 shares

Expires 2029-01-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F4 · derivative.exercise_date: 1/48th of the shares subject to the option vest on each monthly anniversary measured from December 12, 2018 (the "Vesting Commencement Date"), such that 100% of the shares subject to the option will be fully vested and exercisable on the fourth anniversary of the Vesting Commencement Date.

SEC source: 0001567619-21-017166 · doc1.xml · derivative · entry 4

Yednock Ted · CIK 0001818525 · EVP & Chief Scientific Officer

10b5-1 filing: Not disclosed

Ownership: Direct

Disclosed balance after: 10,615

Underlying: Common Stock · 15,000 shares

Expires 2025-01-22

Exercise/conversion can include RSU settlement. Transaction price and option strike are different fields; a missing price is not zero. Derivative and underlying rows can describe the same event.

F3 · derivative.exercise_date: The shares subject to the option vest are fully vested and exercisable.